Podcasts about placebo controlled study

If you're struggling with chronic fatigue syndrome (ME/CFS) or debilitating tiredness that just won't go away, you're not alone—and you're not imagining things. Millions of people suffer from persistent fatigue that conventional medicine often fails to resolve. Fatigue and stress can make everyday tasks like working at a computer feel overwhelming, as seen in this image, which represents the experience of many with chronic fatigue syndrome (ME/CFS) At the Hedberg Institute, I'm always researching botanical compounds that support microcirculation, mitochondrial health, and immune regulation—all vital in restoring energy. That's why I formulated VascuSelect, a synergistic supplement that contains three powerful plant extracts: Ginkgo biloba, grape seed extract, and mango whole fruit powder. Let's dive into why Ginkgo biloba, in particular, stands out for those dealing with ME/CFS and how it works alongside other ingredients in VascuSelect to support your energy and vitality. An Important Study: Ginkgo Biloba for ME/CFS A recent paper published in Frontiers in Pharmacology (2022) titled “A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study” sheds important light on Ginkgo's role in combating chronic fatigue. In this gold-standard clinical trial, 101 adults with ME/CFS received a botanical supplement combining Ginkgo biloba extract (120 mg/day) and Cistanche tubulosa extract (300 mg/day) or a placebo for 60 days. The results were impressive: Significant reductions in fatigue severity Improved physical performance and VO₂ max Enhanced antioxidant status and reduced oxidative stress markers Improved sleep quality and concentration Enhanced quality of life (QOL) and sexual life (SLQ) scores Decreased blood levels of lactic acid and ammonia (both fatigue biomarkers) What's particularly exciting is that Ginkgo biloba played a central role in this formulation. The authors noted that Ginkgo's flavonoids and terpenoids contribute to neuroprotection, vasodilation, and mitochondrial support, all of which are key areas of dysfunction in ME/CFS patients. This study confirms that Ginkgo biloba, known for enhancing blood flow and antioxidant activity, can play a central role in reducing the burdens of ME/CFS. How Ginkgo Biloba Helps Fight Fatigue Ginkgo biloba (standardized to 24% flavonol glycosides and 6% terpenes) is one of the most studied botanical extracts for circulatory and cognitive health. But its applications go far beyond brain support—especially for those with energy-depleting illnesses like ME/CFS. Ginkgo biloba is one of the oldest and most studied medicinal plants. It's been used for centuries in Traditional Chinese Medicine, but modern science is now validating its applications for conditions like ME/CFS, fibromyalgia, and Long COVID. 1. Improves Microcirculation Ginkgo biloba increases blood flow, especially in the small vessels of the brain and extremities. This is critical in ME/CFS, where impaired oxygen delivery to tissues can worsen fatigue. 2. Supports Mitochondrial Function Many people with ME/CFS experience dysfunctional mitochondria—the energy-producing engines of cells. Ginkgo has been shown to protect mitochondrial membranes and improve ATP production, helping the body generate more usable energy. 3. Reduces Oxidative Stress Oxidative stress is a hallmark of ME/CFS and contributes to inflammation, brain fog, and fatigue. Ginkgo's rich flavonoid profile helps neutralize free radicals and reduce oxidative damage. In the study mentioned above, participants taking Ginkgo and Cistanche showed significant increases in antioxidant enzymes like SOD and CAT. 4. Enhances Neurotransmitter Function Ginkgo biloba modulates neurotransmitters like dopamine, serotonin, and norepinephrine—chemicals that regulate mood,

En lo último en salud y fitness edición de enero 2025, vamos a hablar sobre algunos temas que van desde cómo pequeños cambios en nuestra rutina diaria pueden tener un gran impacto en nuestra salud, hasta el sorprendente papel del chocolate oscuro en el rendimiento deportivo. También veremos cómo combinar el ayuno intermitente con el ejercicio puede ser una estrategia efectiva para perder peso, y analizaremos qué dice la ciencia sobre el momento ideal para consumir proteína después de entrenar. Y para cerrar, echaremos un vistazo a una hierba tradicional que está ganando atención por sus efectos en la claridad mental y el estado de ánimo. Atajos del episodio: 01:36 - El Poder de Interrumpir el Sedentarismo1 04:55 - Chocolate Oscuro: ¿Un Impulso Secreto para los Corredores?2 07:37 - Ayuno Intermitente y Ejercicio para Perder Peso3 09:56 - ¿Es la proteína post entrenamiento la clave para el aumento de fuerza?4 14:51 - El poder de la ashwagandha: Un Impulso Natural para la Mente y el Ánimo5   Referencias:  1.      Yin, M., Xu, K., Deng, J., Deng, S. & Chen…, Z. Optimal Frequency of Interrupting Prolonged Sitting for Cardiometabolic Health: A Systematic Review and Meta‐Analysis of Randomized Crossover Trials. … Journal of Medicine … (2024). 2.      Vordos, Z., Deli, I., Anifanti, M., Kluzek, S. & Koutlianos…, N. The Effect of Dark Chocolate Consumption on Arterial Function in Endurance Male Runners: Prospective Cohort Study. Sports (2024). 3.      Cheng, X., Sun, S., Chen, M., Zhou, X. & Rao…, M. Evaluating the efficacy of intermittent fasting and exercise combinations for weight loss: A network meta‐analysis. Obesity … (2024). 4.      Reljic, D., Zieseniss, N., Herrmann, H. J. & Neurath…, M. F. Protein Supplementation Increases Adaptations to Low-Volume, Intra-Session Concurrent Training in Untrained Healthy Adults: A Double-Blind, Placebo …. Nutrients (2024). 5.      Kale, S., Lopresti, A., Suri, R. & Garg…, N. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study. Journal of Psychoactive … (2024).

Today, you'll learn about how to sync up clocks on Earth with clocks on the moon, a nanoparticle that could help relieve stubborn allergies, and the culture of birds. Moon Clock “Researchers figure out how to keep clocks on the Earth, Moon in sync.” by John Timmer. 2024. “The Relativistic Framework to Estimate Clock Rates on the Moon.” by Neil Ashby & Bijunath R. Patla. 2024. Meat Allergy “Tick-borne red meat allergy prevented in mice through new nanoparticle treatment.” by Jim Lynch. 2024. “TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study.” by Ciaran P. Kelly, et al. 2021. Bird Culture “When birds build nests, they're also building a culture.” by Nell Greenfieldboyce. 2024. “Social learning in nest-building birds: a role for familiarity.” by Lauren M. Guillette, et al. 2016. Follow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. Hosted on Acast. See acast.com/privacy for more information.

The New York Times recently called Ozempic a “new match for menopausal weight gain”. But is it? These drugs can be a godsend for those who need them. But there's a lot we need to understand. How do they work? How well do they work? Who benefits from them? What are their risks? What impact do they have on muscle, bone, and performance? How do they affect training and racing? We dig into all of that and more this week with endocrinologist and Ironman triathlete Dr. Jody Dushay who has been researching these drugs for more than a decade. Jody Dushay, M.D., MMSc, is an endocrinologist at the Beth Israel Deaconess Medical Center and assistant professor of medicine at Harvard Medical School. She is also the founder and director of Well Powered, a comprehensive wellness and weight management program. Dr Dushay has studied the effect of pharmacotherapies and dietary interventions on body weight for years, including a large single-site study examining the effects of a glucagon-like peptide receptor agonist on body weight in obese women without diabetes. As a triathlete, she has qualified for Kona 3 times and came in 2nd in her age group at the 2020 Ironman World Championship in St George. You can learn more about her and her work at wellpowered.org.Resources:Dr. Jody Dushay's research:Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetesWeight Loss Outcomes Among Early High Responders to Exenatide Treatment: A Randomized, Placebo Controlled Study in Overweight and Obese WomenSubscribe to the Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-page Feisty Menopause Performance Retreat: Join us from November 21st-23rd, 2024 https://www.feistymenopause.com/retreat Join the FREE Women's Sports Fan Club: fanclub.feisty.co Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Join Level Up:https://www.feistymenopause.com/monthly-membership-1 Support our Partners:Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/ Tifosi Optics: Use code FM20! for 20% off at https://tifosioptics.com/ Lagoon Sleep: Go to LagoonSleep.com/hitplay and take the 2 minute sleep quiz to find your match, and then use the code HITPLAY for 15% off your first purchase This podcast uses the following third-party services for analysis: Podscribe - https://podscribe.com/privacyPodcorn - https://podcorn.com/privacySpotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Chartable - https://chartable.com/privacy

While many have found cannabis to be helpful for sleep, is it anecdotal, or is there science to back up these feelings? In the US, 50 to 70 million adults have chronic sleep problems or sleep disorders, according to SleepHealth.org.FloraWorks set out to validate these claims through double-blind placebo trials, employing the rigorous standards used in pharmaceutical research. These trials aim to provide scientific evidence to support the efficacy of cannabis-derived compounds, such as CBN, in improving sleep.This week, we sit down with Alleh Lindquist to discuss the following:The Therapeutic Potential of CBNSleep Study DesignWhat Cannabinoid is Next for Clinical Trials?And So Much MoreGuest Links:https://www.linkedin.com/in/allehlindquist/https://www.flora-works.com/https://x.com/floraworks_usahttps://www.linkedin.com/company/floraworks/about/Follow us: Our Links.At Eighth Revolution (8th Rev), we provide services from capital to cannabinoid and everything in between in the cannabinoid industry.8th Revolution Cannabinoid Playbook is an Industry-leading report covering the entire cannabis supply chain The Dime is a top 5% most shared  global podcast The Dime is a top 50 Cannabis Podcast Sign up for our playbook here:

While many have found cannabis to be helpful for sleep, is it anecdotal, or is there science to back up these feelings? In the US, 50 to 70 million adults have chronic sleep problems or sleep disorders, according to SleepHealth.org.FloraWorks set out to validate these claims through double-blind placebo trials, employing the rigorous standards used in pharmaceutical research. These trials aim to provide scientific evidence to support the efficacy of cannabis-derived compounds, such as CBN, in improving sleep.This week, we sit down with Alleh Lindquist to discuss the following:The Therapeutic Potential of CBNSleep Study DesignWhat Cannabinoid is Next for Clinical Trials? And So Much MoreGuest Links:https://www.linkedin.com/in/allehlindquist/https://www.flora-works.com/https://x.com/floraworks_usahttps://www.linkedin.com/company/floraworks/about/Follow us: Our Links.At Eighth Revolution (8th Rev), we provide services from capital to cannabinoid and everything in between in the cannabinoid industry.8th Revolution Cannabinoid Playbook is an Industry-leading report covering the entire cannabis supply chain The Dime is a top 5% most shared  global podcast The Dime is a top 50 Cannabis Podcast Sign up for our playbook here:

While many have found cannabis to be helpful for sleep, is it anecdotal, or is there science to back up these feelings? In the US, 50 to 70 million adults have chronic sleep problems or sleep disorders, according to SleepHealth.org.FloraWorks set out to validate these claims through double-blind placebo trials, employing the rigorous standards used in pharmaceutical research. These trials aim to provide scientific evidence to support the efficacy of cannabis-derived compounds, such as CBN, in improving sleep.This week, we sit down with Alleh Lindquist to discuss the following:The Therapeutic Potential of CBNSleep Study DesignWhat Cannabinoid is Next for Clinical Trials? And So Much MoreGuest Links:https://www.linkedin.com/in/allehlindquist/https://www.flora-works.com/https://x.com/floraworks_usahttps://www.linkedin.com/company/floraworks/about/Follow us: Our Links.At Eighth Revolution (8th Rev), we provide services from capital to cannabinoid and everything in between in the cannabinoid industry.8th Revolution Cannabinoid Playbook is an Industry-leading report covering the entire cannabis supply chain The Dime is a top 5% most shared  global podcast The Dime is a top 50 Cannabis Podcast Sign up for our playbook here:

The New York Times recently called Ozempic a “new match for menopausal weight gain”. But is it? How do these drugs work? How well do they work? Who benefits from them? What are their risks? What impact do they have on muscle, bone, and performance? We dig into all of that and more this week with endocrinologist and Ironman triathlete Dr. Jody Dushay who has been researching these drugs for more than a decade. Jody Dushay, M.D., MMSc, is an endocrinologist at the Beth Israel Deaconess Medical Center and assistant professor of medicine at Harvard Medical School. She is also the founder and director of Well Powered, a comprehensive wellness and weight management program. Dr Dushay has studied the effect of pharmacotherapies and dietary interventions on body weight for years, including a large single-site study examining the effects of a glucagon-like peptide receptor agonist on body weight in obese women without diabetes. As a triathlete, she has qualified for Kona 3 times and came in 2nd in her age group at the 2020 Ironman World Championship in St George. You can learn more about her and her work at wellpowered.org.Resources:Dr. Jody Dushay's research:Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetesWeight Loss Outcomes Among Early High Responders to Exenatide Treatment: A Randomized, Placebo Controlled Study in Overweight and Obese Women Follow Us on Instagram:Feisty Menopause: @feistymenopause Feisty Media: @feisty_media Selene: @fitchick3 Subscribe to the weekly Feisty Menopause blog: https://www.feistymenopause.com/feistyinbox Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Join Level Up - Our Community for Active Women Navigating the Menopause Transition:Join: https://www.feistymenopause.com/monthly-membership-1 Leave your questions for Selene:https://www.speakpipe.com/hitplay Get the Free Feisty Women's Guide to Lifting Heavy Sh*t:https://www.feistymenopause.com/liftheavy Support our Partners:Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/

Powerful Possibilities: Struggling with Consistency in ADHDIn this episode, ADHD coach Katherine discusses the issue of consistency for adults living with ADHD and shares various strategies to play with. Katherine had added relevant studies and references below, addressing the neurological reasons behind inconsistency in ADHD diagnosed adults. She suggests adopting new perspectives, like giving yourself an 'A' and focusing on incremental change towards long-term goals. She also suggests using habit stacking and self-regulation techniques. A segment on the attendant benefits of medication for ADHD is included, emphasizing its contribution towards stabilizing attention, improving executive function, and reducing variability in performance. The podcast concludes by underscoring the benefits of community and support from fellow ADHD diagnosed individuals.00:00 Introduction to the Podcast00:09 Understanding Consistency and ADHD02:03 Importance of Consistency in Different Aspects of Life04:21 Challenges of ADHD and Consistency06:23 Strategies for Managing Consistency with ADHD09:49 Understanding the Role of Self-Regulation and Time Management13:17 Exploring Habit Stacking and Behavioral Modification Techniques15:15 Role of Medication in Achieving Consistency15:50 The Impact of Medication on ADHD18:16 Reframing the Idea of Consistency18:38 The Strategy of Giving Yourself an 'A'24:36 The Power of Self-Compassion and Understanding25:19 Changing the Narrative: From Inconsistency to Power27:18 Practical Strategies for Managing ADHD29:29 The Power of Community and Support30:16 Conclusion: Embracing the Powerful Possibilities of ADHD"Memantine in the Treatment of Executive Function Deficits in Adults With ADHD"](https://dx.doi.org/10.1177/1087054714538656)"Occupational Status Is Compromised in Adults With ADHD and Psychometrically Defined Executive Function Deficits"](https://dx.doi.org/10.1177/1087054714564622)Atomoxetine Effects on Executive Function as Measured by the BRIEF-A in Young Adults with ADHD: A Randomized, Double-Blind, Placebo-Controlled Study"](https://dx.doi.org/10.1371/journal.pone.0104175)"A New Understanding of ADHD in Children and Adults: Executive Function Impairments"](https://dx.doi.org/10.4324/9780203067536)Ceceli, Ahmet O., Giavanna Esposito, and Elizabeth Tricomi. "Habit expression and disruption as a function of attention-deficit/hyperactivity disorder symptomology." Frontiers in Psychology 10 (2019): 1997.Ohlmeier, Martin D., et al. "Comorbidity of alcohol and substance dependence with attention-deficit/hyperactivity disorder (ADHD)." Alcohol & Alcoholism 43.3 (2008): 300-304.Harvey, Allison G., et al. "Applying the science of habit formation to evidence-based psychological treatments for mental illness." Perspectives on Psychological Science 17.2 (2022): 572-589.Kovatchev, Boris, et al. "A psychophysiological marker of attention deficit/hyperactivity disorder (ADHD)—defining the EEG consistency index." Applied psychophysiology and biofeedback 26 (2001): 127-140.Hurst, Ruth M., et al. "Internal consistency and discriminant validity of a delay-discounting task with an adult self-reported ADHD sample." Journal of Attention Disorders 15.5 (2011): 412-422.Medina, José A., et al. "Exercise impact on sustained attention of ADHD children, methylphenidate effects." ADHD Attention Deficit and Hyperactivity Disorders 2 (2010): 49-58.Connect with Katherine here:

Un nouvel épisode du Pharmascope est maintenant disponible! Dans ce 124ème épisode, Nicolas, Sébastien, Isabelle et leur invité s'attaquent maintenant à la prise en charge de l'hyperkaliémie en situation non urgente. Les objectifs pour cet épisode sont les suivants: Discuter des causes potentielles d'hyperkaliémie Discuter de la prise en charge non urgente d'une hyperkaliémie Comparer les avantages et les inconvénients des traitements de l'hyperkaliémie Ressources pertinentes en lien avec l'épisode Outil interactif de comparaison de valeurs de laboratoireMcCormack JP, Holmes DT. Your results may vary: the imprecision of medical measurements. BMJ 2020;368:m149 Articles de revue de l'hyperkaliémieLarivée NL et coll. Hyperkalemia: Prevalence, Predictors and Emerging Treatments. Cardiol Ther. 2023;12:35-63. Elliott MJ et coll. Management of patients with acute hyperkalemia. CMAJ. 2010;182:1631-5. Études portant sur le polystyrène sodiqueLepage L et coll. Randomized Clinical Trial of Sodium Polystyrene Sulfonate for the Treatment of Mild Hyperkalemia in CKD. Clin J Am Soc Nephrol. 2015;10:2136-42. Études portant sur le patiromerAgarwal R et coll. Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. 2019;394:1540-50. Weir MR et coll; OPAL-HK Investigators. Patiromer in patients with kidney disease and hyperkalemia receiving RAAS inhibitors. N Engl J Med. 2015;372:211-21. Bakris GL et coll; AMETHYST-DN Investigators. Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial. JAMA. 2015;314:151-61. Jaques DA et coll. Comparative efficacy of patiromer and sodium polystyrene sulfonate on potassium levels in chronic haemodialysis patients: a randomized crossover trial. Clin Kidney J. 2022;15:1908-14. Études portant sur le zirconiumPackham DK et coll. Sodium zirconium cyclosilicate in hyperkalemia. N Engl J Med. 2015;372:222-31. Kosiborod M et coll. Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial. JAMA. 2014;312:2223-33. Roger SD et coll. Efficacy and Safety of Sodium Zirconium Cyclosilicate for Treatment of Hyperkalemia: An 11-Month Open-Label Extension of HARMONIZE. Am J Nephrol. 2019;50:473-480. Zannad F et coll. Efficacy and safety of sodium zirconium cyclosilicate for hyperkalaemia: the randomized, placebo-controlled HARMONIZE-Global study. ESC Heart Fail. 2020;7:54-64. Fishbane S et coll. A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study of Sodium Zirconium Cyclosilicate for Reducing the Incidence of Predialysis Hyperkalemia. J Am Soc Nephrol. 2019;30:1723-33. Spinowitz BS et coll; ZS-005 Study Investigators. Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia: A 12-Month Phase 3 Study. Clin J Am Soc Nephrol. 2019;14:798-809.

News Flashes Cheap baking soda hack for exercise performance: Sodium bicarbonate acts by attenuating the suppressive effects of acidosis on muscle contractility and elicits an ergogenic effect on muscular endurance, power, and velocity: Ergogenic Effects of Sodium Bicarbonate on Resistance Exercise: A Randomized, Double-Blind, Placebo-Controlled Study - take 0.3 g/kg body weight and you can split it into small doses in the 2 hrs. leading up to a workout (e.g. sipping on bicarb water)...13:27 How to get your body to sleep in later: Here's a cool way to reset your circadian clock if you find yourself going to bed later than you want. Go and eat a solid breakfast in the morning rather than fasting or skipping breakfast (bonus points if you can include 30 to 40 g of protein, amino acids, or collagen with that meal). Early Time-Restricted Eating Advances Sleep In Late Sleepers: A Pilot Randomized Controlled Trial...33:49 To ice or not to ice? Some claim that icing will inhibit recovery… But here's the latest science: To Ice or Not To Ice? Icing Can Promote Muscle Regeneration After Mild Injury...47:07   Listener Question Q: Robbie asks: I'd love for you to look into a company called "LifeWave." I've been into biohacking, nutrition, and fitness (and following you) for some time. I've never had anything make me feel this way. It's a patch that turns on GHK-cu peptide, which in turn stimulates stem cells. I'd like your opinion on the science behind it. He holds patents on the tech... 54:08 Full Show Notes: https://bengreenfieldlife.com/462Episode sponsors: KetoMed: KetoMed is the first OTC direct-to-consumer ketogenic/antifungal ‘complete' nutraceutical drink. Visit ketomed.com/ben use code: Ben40 to receive $40.00 off a 30-day supply. Essentia: Only organic mattress to score best on eliminating all sleep-interrupting stimulants. $100 off your mattress, use code BENVIP myessentia.com/bengreenfield. Organifi: Get the restful sleep you need with the most soothing ingredients! Visit Organifi.com/Ben for 20% off your order. BGL Masterclass: The course is structured to help you identify barriers and your biggest weaknesses that prevent you from making the most of your available time and resources. Visit BenGreenfieldLife.com/masterclass to secure your spot. Ben Greenfield Coaching - Elite Plan: Time to transform your health and fitness journey with the new Elite Plan from Ben Greenfield Coaching. See omnystudio.com/listener for privacy information.

Auch wenn Adaptogene seit Jahrhunderten in der chinesischen Medizin und Ayuverda genutzt werden, sind sie erst seit wenigen Jahren auch bei uns im Fokus. Was sind Adaptogene? Was können Adaptogene leisten? Welche Adaptogene gibt es? Wie wirken Adaptogene? Was muss bei der Einnahme beachtet werden? Viel Spaß mit der Folge, deine Larry Blutbild-Analyse: https://calendly.com/larissareinelt/blutbild-analyse Studien-Auswahl: Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity, Panossian/Wikman, 2009 Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals, Panossian, 2017 Chandrasekhar, K. et al. (2012): A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. In: Indian Journal of Psychological Medicine, 34 (3), p. 255-262. Cooley, K. et al. (2009): Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974. In: PLoS One, 4 (8), p. e6628. Andrade, C. et al. (2000): A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera. In: Indian Journal of Psychiatry, 42 (3), p. 295-301. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application, Durg/Bavage/Shivaram, 2022. Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury, Tang/Xin/Thang, 2022. Qi, Y. et al. 2017. Anti-Inflammatory and Immunostimulatory Activities of Astragalosides. Am J Chin Med. 45(6):1157–67. Wan, C. P. et al. 2013. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol Sin. 34(4):522–30.

Dr. Shannon Westin, Dr. Lakshmi Sandhya, and Dr. Prasanth Ganesan discuss the use of olanzapine to treat chemotherapy-related anorexia, as recently published in JCO. TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Dr. Shannon Westin: Hello, everyone, and welcome to another episode of JCO After Hours, the podcast where we get in-depth on manuscripts published in the Journal of Clinical Oncology. As always, I'm your host, Dr. Shannon Westin, GYN Oncologist and Social Media Editor for JCO. I'm very excited to be here today.  And please note that our participants do not have any conflict of interest.   So we are going to discuss a really exciting paper today entitled the "Randomized, Double-Blind, Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients with Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer." And this was published in the JCO on March 28, 2023, and has gotten a lot of excitement.  And so I'm very thrilled to have two of the authors with me today. First is Dr. Lakshmi Sandhya. She's a Junior Consultant at the SVICCAR Hospital in Tirupati, India. Welcome, Dr. Sandhya. Dr. Lakshmi Sandhya: Thank you so much for the opportunity to be here. Dr. Shannon Westin: And I also have the senior author here today, Dr. Prasanth Ganesan. He is a Professor in the Department of Medical Oncology at JIPMER, which is the Jawaharlal Institute of Postgraduate Medical Education and Research in Puducherry, India. Welcome, sir.  Dr. Prasanth Ganesan: Thank you. Thank you very much, Dr. Westin. It's good to be here. Thank you very much.  Dr. Shannon Westin: Great to have you both. So we're going to get right to it. I think this is an excellent paper and certainly something we see across many of our patients who are diagnosed with cancer and who are receiving treatment for cancer. But first, I want to level set. What is the true definition of chemotherapy-related anorexia, and really approximately how many patients do you think it impacts?  Dr. Prasanth Ganesan: As you know, anorexia itself is very common in advanced cancers. Almost like maybe 80%, 90% of patients have some form of anorexia. But at diagnosis, it depends on the type of cancers. Very high in upper GI cancers, esophagus, stomach, pancreas, or lung cancer. But when we talk about chemotherapy-related anorexia, we specifically mean anorexia that is brought on or probably worsened by chemotherapy. So this depends a lot on the regimen that is used. So studies in lung cancer, upper GI cancer that have used something like platinum agents, maybe as high as 50% to 80%. Now, the challenge is how much of it is contributed by the underlying cancer itself and how much of it is worsened by the chemotherapy. It's tough to say, but I think we all have seen that chemotherapy does kind of really increase the anorexia in many of these patients. So I would say the problem is common. Depends on the type of cancer, the type of agent being used, and also sometimes on how intently we are looking for it. Dr. Shannon Westin: You bring up a great point in really kind of making sure that we're screening our patients for it and understanding who's actually experiencing those things. And I do think putting it on our list of things that we, on a day-to-day basis, discuss with our patients is really relevant, although I will say sometimes we haven't done that because we don't have a good treatment. So that's what makes your paper so exciting. But before we get into the results of the paper, why don't we talk a little bit more about some of the factors that contribute to anorexia? Dr. Sandhya, I don't know if you want to elaborate a little bit on some of those. Dr. Lakshmi Sandhya: Yeah. So most important would be the cancer type and the type of chemotherapy agent being used. So, as we mentioned, some cancer types have high anorexia incidence even at baseline. So the most important and prominent would be the upper gastric cancers and the pancreatic and lung cancer. Among the chemotherapy types, I think the platinum agents are known to cause anorexia more often and also associated with nausea or vomiting. So anorexia and weight loss is not very common in other cancers like breast, if you see, or ovarian cancer during the therapy. In fact, there has been weight gain in most of the patients with breast cancer, and most of the data which comes from breast cancer show that weight loss is experienced only by around 5% of the patients. So we would say the factors contributing most commonly would be the type of cancer and the chemotherapy that is being used.  Dr. Shannon Westin: Yeah, I think it's a great point. As a gynecologic oncologist, we do a lot of platinum, but we balance it, especially in upfront with paclitaxel or taxanes and we're giving steroids as premeds for them. And so we definitely see patients expecting to lose weight and instead actually getting hungry with the steroid use and eating to some degree.  Dr. Prasanth Ganesan: So I just want to add that even targeted agents, when you use something like sunitinib or everolimus, some of these agents, even they have got anorexia, probably 20% to 30%. So we did not include them in our study, but I'm just saying that even with targeted agents, we do get anorexia, at least some of them. So it's a problem across them. Dr. Shannon Westin: Yeah, we've been using PARP inhibitors and definitely can see that nausea, vomiting, and anorexia in that population. So I appreciate you making a point that that wasn't included but could be potentially extrapolated here. And then I guess the other question that I have is how does anorexia impact cancer-related outcomes? Does it have an impact in that way? Dr. Prasanth Ganesan: I believe it does, but it's probably not in a direct sort of way. So anorexia is strongly associated with weight loss and some amount of cachexia, and weight loss per se has been associated with poor outcomes across the board. There's a lot of data, especially in lung, upper GI cancers, and even head and neck cancer where weight loss before or during therapy has been associated with poor survival impact. So, again—in pancreatic cancer, it's associated with poor survival. So it's difficult to pin the weight loss only on anorexia here because weight loss is often multifactorial, but yeah, anorexia is probably a significant factor which is also adding to that. So I would say indirectly, yes, anorexia has an impact on cancer-related outcomes. Yes.  Dr. Shannon Westin: And I guess just getting into kind of what we can do before we get into the novel findings in your study, I know we've tried to talk about some dietary-related interventions that we can utilize to combat anorexia. Anything that you all have found to be most helpful from a diet standpoint?  Dr. Lakshmi Sandhya: So, from the diet standpoint, I would say dietary counseling is generally recommended for all the patients. To be very frank, we don't usually have a dietitian to spare at our outpatient clinic to counsel all the patients. So this is not something we are able to practice in the clinic. But in this trial, of course, we had a dietitian who counseled all the patients, and she gave them a diet chart to follow and gentle advice on what item to use and which is good, specifically emphasizing on high-calorie and high-protein diet. So we did not find that any particular dietary intervention is impactful. If you've seen various studies on dietary intervention, they have shown mixed results on improvement of anorexia or weight gain. So we're not sure whether dietary counseling particularly has impacted the results. Dr. Prasanth Ganesan: Yes. Dr. Shannon Westin: Okay. And then I imagine that would be one of the reasons that led to your exploration of this agent of olanzapine to treat chemotherapy-related anorexia. And can you just walk us through any data that existed kind of prior to your study to support this work? Dr. Prasanth Ganesan: Yeah, definitely. I think olanzapine has been in the news for the last decade or so because we've been using it consistently for vomiting and nausea in patients getting emetogenic therapies. So there are at least three studies which we found for olanzapine in cancer anorexia. I think one was from Dr. Navari, and he had done a randomized trial comparing megestrol with megestrol plus olanzapine. And this was done in patients with advanced cancers, and they found about 35% of the patients in the olanzapine group had additional weight gain. So it was useful. And this was not a very recent study. It's almost done about 10 years back. Dr. Shannon Westin: Oh, wow. Dr. Prasanth Ganesan: Then, after that, there was an interesting phase I study by Dr. Naing, and that was from MD Anderson, and that looked at various doses of olanzapine also. And that was interesting for us because that's where we got our starting dose of 2.5 mg because even at this dose, there was an effect on anorexia. So that was a very useful study because we were also trying to figure out what is the best dose to use in our trial. So that's why we went with the 2.5 mg.  Dr. Shannon Westin: That's great. I know everyone's excited to hear about the results. So, Dr. Sandhya, do you want to walk us through the design of the study and maybe how you chose your patient population? I think you've already kind of hinted at it, taking people that at baseline have high levels of anorexia.  Dr. Lakshmi Sandhya: Yes, sure. So this was designed as a phase III randomized blinded trial. So we used olanzapine in one arm and the matched placebo in another. So we gave olanzapine at a dose of 2.5 mg once a day for 12 weeks. And similarly, a placebo which looked similar was given to the other group. So we assessed for weight gain as an objective measure and improvement in appetite as one of the endpoints, which is more of a subjective measure. And we wanted to focus on population where the problem of anorexia was maximum. So we focused on upper GI, lung and pancreas, and biliary tract cancers to make it more uniform when it comes to anorexia. Dr. Prasanth Ganesan: Just to add a point that, even though we had included three or four types of cancer, almost 60% of our patients were actually gastric cancer patients because that probably reflects the profile of patients that we see at our center. It's a very common cancer in our place, and the next common was the lung cancer. We had only about 15% of patients who had pancreaticobiliary cancer. Dr. Shannon Westin: That makes sense. Obviously, wherever we're enrolling is what we're going to see, but I think hopefully these data can be extrapolated across all cancer types. So you mentioned that your primary endpoint was weight loss as well as the improved appetite. Can you walk us through, Dr. Sandhya, what you found? What were your results? Dr. Lakshmi Sandhya: So we had two primary endpoints. One was weight gain, and the other was improvement in appetite. So we wanted to use weight gain, as I said, since we felt that it is more of an objective measure than measuring anorexia. And olanzapine in our trial improved weight more than 5% from baseline in 60% of the patients in the olanzapine group and 9% in the placebo. Correspondingly, we have also measured improvement in appetite by using various questionnaires, which are validated. So one was visual analog scale, and the other was FAACT AC subscale, which we used during this trial. So yes, olanzapine worked well. We had hoped to show improvement in weight in about 30%, but surprisingly, we found that the weight gain was about 60% in the olanzapine group.  Dr. Shannon Westin: That's so great. It's always nice when you outperform your wildest dreams. So congratulations. Were there other secondary endpoints you observed that were impacted by the olanzapine?  Dr. Prasanth Ganesan: Yeah. So we did have a bunch of secondary endpoints because, again, we were worried when we started off because this is a subjective endpoint and we're not really sure how it's going to pan out. So we looked at some endpoints like quality of life, obviously, and we also had some nutritional assessment with the SDA and consistently, all of these showed improvement with the olanzapine. And what is most interesting for us was the grade III/IV side effects of the chemotherapy regimens, and these were reduced in the olanzapine. So this was something which we were looking for because consistently—we had also done some earlier studies in elderly populations where we found that the nutrition was an important factor in determining the toxicities of therapy. So that's why we wanted that as an endpoint.  And in fact, we found that patients who started at lower doses in cycle one due to poor performance status and nutrition, many of them could actually increase their dose in their subsequent cycles and this was more commonly seen in the olanzapine arm. So this was something which was very pleasant and which was something which we found was very interesting. So we could deliver more better chemotherapy intensity in these patients, thanks to their better nutrition.  Dr. Shannon Westin: That's so exciting. Such a nice concrete thing for patients as well. I mean, obviously being able to gain weight is something that they could see and having that appetite, but knowing that they had less side effects from their chemo as well is such an important impact. I guess, on the converse side, were there any negative impacts to the olanzapine?  Dr. Lakshmi Sandhya: Not really. We specifically asked patients about olanzapine-induced side-effects like drowsiness. At this dose of 2.5 mg per day, we found very little side-effects which would be attributed to olanzapine. As we mentioned, overall side-effects were also lowered in olanzapine arm. So with short duration of three months and at this dose, we believe that olanzapine is fairly safe. Dr. Shannon Westin: And that's great. And I'd be remiss—especially here in the States, this is high discussion around financial toxicity. As I recall, it's a pretty inexpensive agent. Is there any kind of negative financial impact for the use of this drug?  Dr. Prasanth Ganesan: Yeah, this is the best part. In India, for three months, olanzapine costs about 300 rupees. That would be like $4 or something for three months of therapy. I think that's pretty easily affordable across the board. Most patients here can easily buy this. And I'm not sure about the cost in the US, but I'm guessing it would not be too high. It's been around for some time. It should be out of patent and things like that. So I think it's a very inexpensive drug.  Dr. Shannon Westin: Yeah, we like that, like reuse of an old drug to do something good. The other question I had for you all is just any thoughts about how these results might compare to other things that we use, like glucocorticoids or progestational agents? I know we didn't have that as a comparator, but just your thoughts on that. Dr. Prasanth Ganesan: So, in terms of efficacy in reducing anorexia, it's difficult to compare because, if you see the studies of steroids and megestrol, most of them have been done by patients with more advanced cancers, not necessarily patients who are getting chemotherapy in the front line. But we think the side-effect profile is what gives an advantage to olanzapine because three months of steroids, even if you say lower doses of dex at 4mg or something, which I would want to use in a newly diagnosed cancer patient. Megestrol also seems to have problems like DVT and is actually much more expensive, at least in our context. I mean, if you compare with these aspects, I would definitely put olanzapine ahead, but as you said, this is not a direct comparison between those so-called existing agents. Dr. Shannon Westin: Yeah, I think that's a very thoughtful answer, but I think something we just needed to cover, even though we know that it wasn't a randomized trial between those two. Any limitations, Dr. Sandhya, on these results? Anything that you wish you had done a little differently? Dr. Lakshmi Sandhya: Yeah. As such, it is applicable only in the context of upper GI and lung cancers, as we have mostly included upper GI and lung cancers, and most of the patients, almost two-thirds of the patients included in our study, were gastric cancers. So also the duration that we used was only for 12 weeks. So we don't know whether longer duration will benefit more or harm. And the sustainability of weight beyond 12 weeks, we have not actually looked into. So, yeah, maybe these are few limitations that we can think about. Dr. Shannon Westin: That's very true. And I think that—I mean, obviously, when we design trials, we have to have a limit. Do you have plans—are you able to follow these patients out a little further? Do you know if clinically they're continuing it off-trial?  Dr. Prasanth Ganesan: So we have done that. So we have been following them for their survival data, and we just completed the analysis. So I think we have to really publish that next. So it is looking interesting. So some interesting data there. So that's something which we found it very exciting. Dr. Shannon Westin: Okay, good. Dr. Prasanth Ganesan: So that is something which is out there. And we also looked at some data on improvement of their muscle mass and on their CAT scans, we looked at that. So that's also something which we are trying to analyze and see whether we can have more concrete or objective endpoints in terms of improvement of the muscle mass and adipose tissue and things like that. Dr. Shannon Westin: Okay, good. Well, we'll look forward to that in a future version of the JCO, I hope. I guess the last thing is where do we go from here? You kind of hinted at this a little bit. I'm kind of bummed because I was ready to start implementing this in my clinic tomorrow. Dr. Prasanth Ganesan: So it's just safe, it's effective, and it's cheap. So I don't see any reason we should not start implementing something like this straightaway. I use it quite commonly, definitely for patients who are part of the trial population. And even for any patients with advanced cancer on or off chemotherapy with anorexia or weight loss, I'm comfortable to use olanzapine at least for a short term. And many patients at least they come back and say that it does help them. And I've not seen any side-effects at this dose of olanzapine. So it seems very safe to use. I'm comfortable to put it in the clinic right away.  Dr. Shannon Westin: Dr. Sandhya, what do you think?  Dr. Lakshmi Sandhya: I feel, in this trial, we came across the safety part of it and also the affordability part of it, and definitely it has been very encouraging results, so yeah. So, day-to-day practice, it can be used. Dr. Shannon Westin:  Well, great. I think this is super-educational, and I hope everyone else is just as convinced as I am how important this work was and how potentially impactful it will be for our patients. I just want to again thank these wonderful physicians and researchers. Dr. Sandhya, Dr. Ganesan, thank you so much for your time and a little bit of a late time for this taping across the globe. So thanks again for being here. Dr. Prasanth Ganesan: Thanks, Dr. Westin, for giving us this chance.  Dr. Lakshmi Sandhya: Thank you so much. Dr. Shannon Westin: So, again, y'all, this has been JCO After Hours discussing the important paper, "Randomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer,” published March 28th, ‘23. We are just so grateful that you joined us and hope you'll check out the other podcast offerings on the website. Take care. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Drs Stanley Cohen and Philip Mease review the 2022 ACR meeting topics, including new treatments, trial data, and what they think are the most pressing unmet needs in the field. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984271). The topics and discussions are planned, produced, and reviewed independently of the advertisers. This podcast is intended only for US healthcare professionals. Resources Etanercept in the Treatment of Psoriatic Arthritis and Psoriasis: A Randomised Trial https://pubmed.ncbi.nlm.nih.gov/10972371/ Group for Research and Assessment of Psoriasis and Psoriatic Arthritis https://www.grappanetwork.org/ American College of Rheumatology (ACR) Convergence https://www.rheumatology.org/Annual-Meeting Bimekizumab Treatment in Biologic DMARD-Naïve Patients With Active Psoriatic Arthritis: 52-Week Efficacy and Safety Results From a Phase 3, Randomized, Placebo-Controlled, Active Reference Study https://acrabstracts.org/abstract/bimekizumab-treatment-in-biologic-dmard-naive-patients-with-active-psoriatic-arthritis-52-week-efficacy-and-safety-results-from-a-phase-3-randomized-placebo-controlled-active-reference-study/ Bimekizumab Treatment in Patients With Active Psoriatic Arthritis and Inadequate Response to Tumor Necrosis Factor Inhibitors: 16-Week Efficacy and Safety From a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study https://acrabstracts.org/abstract/bimekizumab-treatment-in-patients-with-active-psoriatic-arthritis-and-inadequate-response-to-tumor-necrosis-factor-inhibitors-16-week-efficacy-and-safety-from-a-phase-3-randomized-double-blind-pla/ Bimekizumab Improvements in Efficacy on Disease Activity Assessed via Composite Endpoints in Biologic DMARD-Naïve and TNFi-IR Patients With Active PsA: Pooled 16-Week Results From Phase 3 Randomized, Placebo-Controlled Studies https://acrabstracts.org/abstract/bimekizumab-improvements-in-efficacy-on-disease-activity-assessed-via-composite-endpoints-in-biologic-dmard-naive-and-tnfi-ir-patients-with-active-psa-pooled-16-week-results-from-phase-3-randomized/ Bimekizumab Versus Adalimumab in Plaque Psoriasis https://pubmed.ncbi.nlm.nih.gov/33891379/ A Head-to-Head Comparison of the Efficacy and Safety of Ixekizumab and Adalimumab in Biological-Naïve Patients With Active Psoriatic Arthritis: 24-Week Results of a Randomised, Open-Label, Blinded-Assessor Trial https://pubmed.ncbi.nlm.nih.gov/31563894/ GRAPPA Treatment Recommendations: 2021 Update https://pubmed.ncbi.nlm.nih.gov/35293339/ Deucravacitinib Prescribing Information https://packageinserts.bms.com/pi/pi_sotyktu.pdf Safety and Efficacy of Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 Inhibitor, in Patients With Psoriatic Arthritis: 52-Week Results From a Randomized Phase 2 Trial https://acrabstracts.org/abstract/safety-and-efficacy-of-deucravacitinib-an-oral-selective-tyrosine-kinase-2-inhibitor-in-patients-with-psoriatic-arthritis-52-week-results-from-a-randomized-phase-2-trial/ Deucravacitinib Reduces Interferons, B Cell Pathways, and Serological Biomarkers of Systemic Lupus Disease Activity: Pharmacodynamic Analysis From the Phase 2 PAISLEY Study https://acrabstracts.org/abstract/deucravacitinib-reduces-interferons-b-cell-pathways-and-serological-biomarkers-of-systemic-lupus-disease-activity-pharmacodynamic-analysis-from-the-phase-2-paisley-study/ Nanobody: A Promising Toolkit for Molecular Imaging and Disease Therapy https://pubmed.ncbi.nlm.nih.gov/33464410/

How do you identify postinfection irritable bowel syndrome? How long will it last and how do you treat it? Join expert physicians Lin Chang and Madhu Grover as they discuss. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987260). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Post-Infection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34024451/ Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery https://pubmed.ncbi.nlm.nih.gov/16890598/ Sex-Gender Differences in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/30347934/ Prevalence of Gastrointestinal Symptoms Six Months After Bacterial Gastroenteritis and Risk Factors for Development of the Irritable Bowel Syndrome: Postal Survey of Patients https://pubmed.ncbi.nlm.nih.gov/9080994/ The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/21256129/ Randomised Placebo-Controlled Trial of Dietary Glutamine Supplements for Postinfectious Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/30108163/ Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36858143/ Double-blind Placebo-Controlled Study of Mesalamine in Post-Infective Irritable Bowel Syndrome – A Pilot Study https://pubmed.ncbi.nlm.nih.gov/22783919/ Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/28846594/ The COVID-19 Pandemic and Post-Infection Irritable Bowel Syndrome: What Lies Ahead for Gastroenterologists https://pubmed.ncbi.nlm.nih.gov/35944588/ The Prevalence of Irritable Bowel Syndrome After Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Their Association: A Systematic Review and Meta-Analysis of Observational Studies https://pubmed.ncbi.nlm.nih.gov/36902651/ Postinfection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34789582/ COVID-19 as a Trigger of Irritable Bowel Syndrome: A Review of Potential Mechanisms https://pubmed.ncbi.nlm.nih.gov/34887641/ Incidence and Predisposing Factors for De Novo Post-COVID-19 Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36468570/ Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/32916129/ Serine Proteases as Luminal Mediators of Intestinal Barrier Dysfunction and Symptom Severity in IBS https://pubmed.ncbi.nlm.nih.gov/30923071/ Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy https://pubmed.ncbi.nlm.nih.gov/28274108/ Performance and Interpretation of Hydrogen and Methane Breath Testing Impact of North American Consensus Guidelines https://pubmed.ncbi.nlm.nih.gov/35366119/

Do you have a patient suffering from postpartum depression? In this episode, we discuss a new study on light therapy as a potential treatment for postpartum depression, including the response rate, adverse effects, and effects on sleep quality. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CMEs: Quick Take Vol. 43 Efficacy of Bright Light Therapy in Perinatal Depression: A Randomized, Double-Blind, Placebo-Controlled Study

https://psychiatry.dev/wp-content/uploads/speaker/post-12091.mp3?cb=1677715124.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Double-Blind Placebo-Controlled Study of Memantine in Trichotillomania and Skin-Picking Disorder – Jon E Grant et al. American Journal of Psychiatry. 2023. TrichotillomaniaFull EntryDouble-Blind Placebo-Controlled Study of Memantine in Trichotillomania and Skin-Picking Disorder –

In this episode of Hey Coach Radio, your host William Grazione is joined by Coach Gillis Pellegrin to go over their Top 5 Supplements for Women and how to use them. You may be surprised to learn how you can improve your quality of life by supplementing for a deficiency in vitamins and minerals. Learn if these supplements are for you. *By listening to this podcast, you agree not to use this podcast as medical advice to treat any medical condition in either yourself or others, including but not limited to clients that you are coaching. Consult your own physician for any medical issues that you may be having. The information and advice mentioned in this podcast is not intended to diagnose, treat, cure, or prevent any disease or condition. Studies referred to in this podcast: A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/

Today we're going to be talking about sleep. Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. Special discount code so you can save $50 off of the purchase of an Oura ring. There are only a few discounts available. Get yours here: https://ouraring.com/discount/ff9ae56157 **Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/ ** Level up your products: https://www.ewg.org/ewgverified/ **Interesting articles for more information** The Sleep of the Ring: Comparison of the ŌURASleep TrackerAgainst Polysomnography: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095823/pdf/nihms-1500634.pdf GABA and L-theanine mixture decreases sleep latency and improves NREM sleep: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/pdf/iphb-57-1557698.pdf Effect of wearables on sleep in healthy individuals: a randomized crossover trial and validation study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849816/pdf/jcsm.8356.pdf Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723420/pdf/nutrients-11-01859.pdf Plant Extracts for Sleep Disturbances: A Systematic Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191368/pdf/ECAM2020-3792390.pdf Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155219/pdf/nrp-15-309.pdf Naturally Occurring Consecutive Sleep Loss and Day-to-Day Trajectories of Affective and Physical Well-Being: https://academic.oup.com/abm/article-abstract/56/4/393/6314765?redirectedFrom=fulltext Dietary saffron reduced the blood pressure and prevented remodeling of the aorta in L‐NAME‐induced hypertensive rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764118/pdf/IJBMS-11-1143.pdf

2023 RWCS Meeting Dr. Arthur Kavanaugh invites you to join him for the 2023 RWCS meeting in February 2023. Dr David Liew JAK inhibitor VS TNF inhibitor, Infections in East Asian Patients. Abstract 302 Early Diagnosis of Axial Spondyloarthritis Dr. Antoni Chan talks with Dr.  Nelly Ziade at ACR22 Convergence in Philadelphia, PA. Abstracts 1512: What Is the Best Referral Strategy for Axial Spondyloarthritis? A Prospective Multicenter Study of 515 Patients with Suspicious Chronic Low Back Pain Abstract 1517: Value of the Anti-CD74 Antibodies for the Diagnosis of Axial Spondyloarthritis: Results of a Prospective Study in Patients with Suspicious Low Back Pain New Treatments for SLE? Dr. Michelle Petri discusses abstract 1117 presented at ACR22 Convergence meeting in Philadelphia, PA.  Abstract 1117: Efficacy and Safety of Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in Patients with Active Systemic Lupus Erythematosus: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Should you get 8k steps in a day, or 10k or 12k? Does it matter and make a difference? What about waist trainers? Are they worth the money? And how accurate is that watch of yours at tracking calories burned? These are the main topics we'll dive into in today's episode. Need Optimized training programs that have QUALITY exercise selection? Click HERE to sign up for the LiftingLindsayAPPElectrolytes I talked about - Link HEREResearch citedWatches overestimating  calories burned (PMIDs 3495939, 35060915, & 32897239)Browne, J.D., et al., Lifestyle Modification Using a Wearable Biometric Ring and Guided Feedback Improve Sleep and Exercise Behaviors: A 12-Month Randomized, Placebo-Controlled Study. Front Physiol, 2021. 12: p. 777874.

Drs John Kane and Stefan Leucht discuss the effectiveness and optimal dosing of antipsychotic medications in the treatment of schizophrenia. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969527). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Toward a Phenomenological Psychotherapy for Schizophrenia https://www.karger.com/Article/FullText/500163 APA Releases New Practice Guideline on Treatment of Patients with Schizophrenia https://www.psychiatry.org/newsroom/news-releases/apa-releases-new-practice-guideline-on-treatment-of-patients-with-schizophrenia Pharmacological Treatments for First-Episode Schizophrenia https://academic.oup.com/schizophreniabulletin/article/31/3/705/1894509?login=false Putting the Efficacy of Psychiatric and General Medicine Medication Into Perspective: Review of Meta-analyses https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/putting-the-efficacy-of-psychiatric-and-general-medicine-medication-into-perspective-review-of-metaanalyses/39C15F3428BDD1F8A4C152B67C06A5A6 The Nature of Relapse in Schizophrenia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599855 20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia https://pubmed.ncbi.nlm.nih.gov/29621900/ Amisulpride and Olanzapine Followed by Open-Label Treatment With Clozapine in First-Episode Schizophrenia and Schizophreniform Disorder (OPTiMiSE): A Three-Phase Switching Study https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(18)30252-9/fulltext Clozapine https://reference.medscape.com/drug/clozaril-versacloz-clozapine-342972 Lurasidone Dose Escalation in Early Nonresponding Patients With Schizophrenia: A Randomized, Placebo-Controlled Study https://www.psychiatrist.com/jcp/schizophrenia/lurasidone-in-early-nonresponding-schizophrenia/ Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.19010034 Examination of Dosing of Antipsychotic Drugs for Relapse Prevention in Patients With Stable Schizophrenia: A Meta-analysis https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2783296 Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2725088

Ashwagandha: The Supplement You Need for 2022  (Abridged Episode)      I need to take ashwa-whaaatttt? It's rare that we push taking dietary supplements as a primary way to boost mental wellness, so the fact that we're doing a whole episode on this naturopathic supplement should tell you a lot. In today's episode we're talking about Ashwagandha—the adaptogen that's skyrocketed in popularity in 2020 and 2021 and it's powerful potential to help you manage stress and anxiety.   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com   References mentioned: A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults   An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera)   Learn More About Our Hosts:  Carolyn Williams PhD, RD Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeating@gmail.com Produced by Lester Nuby OE Productions

Ashwagandha: The Supplement You Need for 2022  (Abridged Episode)      I need to take ashwa-whaaatttt? It's rare that we push taking dietary supplements as a primary way to boost mental wellness, so the fact that we're doing a whole episode on this naturopathic supplement should tell you a lot. In today's episode we're talking about Ashwagandha—the adaptogen that's skyrocketed in popularity in 2020 and 2021 and it's powerful potential to help you manage stress and anxiety.   Link to Full Episode: Ashwagandha - The Supplement You Need For 2022   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com   References mentioned: A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults   An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera)   Learn More About Our Hosts:  Carolyn Williams PhD, RD Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeating@gmail.com Produced by Lester Nuby OE Productions

Ashwagandha: The Supplement You Need for 2022      I need to take ashwa-whaaatttt? It's rare that we push taking dietary supplements as a primary way to boost mental wellness, so the fact that we're doing a whole episode on this naturopathic supplement should tell you a lot. In today's episode we're talking about Ashwagandha—the adaptogen that's skyrocketed in popularity in 2020 and 2021 and it's powerful potential to help you manage stress and anxiety.   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com   References mentioned: A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults   An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera)   Learn More About Our Hosts:  Carolyn Williams PhD, RD Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeating@gmail.com Produced by Lester Nuby OE Productions

Ashwagandha: The Supplement You Need for 2022      I need to take ashwa-whaaatttt? It's rare that we push taking dietary supplements as a primary way to boost mental wellness, so the fact that we're doing a whole episode on this naturopathic supplement should tell you a lot. In today's episode we're talking about Ashwagandha—the adaptogen that's skyrocketed in popularity in 2020 and 2021 and it's powerful potential to help you manage stress and anxiety.   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com   References mentioned: A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults   An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera)   Learn More About Our Hosts:  Carolyn Williams PhD, RD Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeating@gmail.com Produced by Lester Nuby OE Productions

Your body is designed to remove toxins and waste on its own. But do you know how to support it? Tune in this week to learn how! We all have a Natural Detox Response. When we activate this response in our bodies, we increase our ability to protect your immune system naturally, and clear out the everyday toxins that find their way into your food, the air you breathe, the water you drink, and the surfaces you touch.   Natural Detox Response When we activate this response in our bodies we: Increase our ability to protect your immune system naturally clear out the everyday toxins that find their way into your food, the air you breathe, the water you drink, and the surfaces you touch Your body is designed to remove toxins and waste on its own. And while your organs are there to keep you alive, each and every one of them plays its own role in keeping you healthy. There are 4 organs more than any others that work together to create your personal detox machine working inside of you right now…   Your Liver acts like a filter in blocking out toxic substances in foods and drinks from passing into your bloodstream… Your Kidneys are working around the clock to then filter that blood and flush out those toxins when you use the bathroom. Your Colon puts in overtime taking care of the larger toxins and breaking them down with healthy bacteria before they can do you any harm… And Your Lungs play their part in filtering out the toxins that enter your body from breathing. As you can see, the human body was designed as a fully equipped detox machine.   How To Support Your ‘Detox Machine' You must take steps to support your body's Natural Detox Response System and I'm about to show you how right now… Once you begin to support your body's natural detox abilities, you'll notice that your body's “normal state” tends to shift toward health instead of inching toward illness. So what is it that your body needs to trigger your Natural Detox Response?   DETOX SUPPORT NUTRIENT #1 – Matcha   Matcha tea is the “it” health beverage of the moment, but this amazing superfood is more than just a “fad” trend. The history of matcha for health goes back to the Tang Dynasty in China, which ruled between the 7th – 10th centuries. Over time, the matcha tea made its way to Japan, where it began to be incorporated into special tea ceremonies. And today, countless scientific studies show us just how powerful this little nutrient is. First, it boosts chlorophyll levels. Chlorophyll can help improve liver function, which also boosts your body's ability to flush out toxins. So, it's no surprise that it's been shown to help with the excretion of heavy metals, dioxins, and other persistent chemicals, And the second part of the magic of matcha is big energy without the crash. Unlike the caffeine that comes from coffee beans, the caffeine in Matcha is released slowly into your system along with L-theanine, giving you a steady supply of energy so your body's natural detox system can function at its highest levels.   Other Benefits of Matcha: Protection against free radicals. You've heard about the antioxidant power of green tea, right? Well, matcha has 137 times more antioxidants than regular green tea! And 20 times more than a serving of blueberries. Antioxidants are key to disease prevention and are one of the best ways to boost your health. Cancer prevention. Catechins, which are potent cancer-fighters counteracting the effect of pollutants, chemicals, UV rays, and radiation, are a unique set of antioxidants found only in matcha. According to the National Cancer Institute, green tea is one of the most powerful cancer-fighters. Calm alertness. Matcha tea is rich in the amino acid L-Theanine, which is what left those Zen monks (and me) feeling calm, yet alert and focused. While it is a component of all green and black teas, matcha contains roughly five times the amount of L-theanine. Linked to increased concentration, learning ability and even physical endurance, L-Theanine gives you a boost without the caffeine jitters. (6) As someone who absolutely cannot handle the caffeine in coffee, matcha is my go to pick-me-up. If your clients or patients struggle with caffeine jitters, a cup of matcha might be a better choice. Anti-aging properties. A common drink in Okinawa, Japan, one of the few Blue Zones, where people live the longest, healthiest lives, matcha is said to reduce inflammation and oxidation, contributing to anti-aging. Fat-burning properties. One study found that matcha tea increased thermogenesis, the body's rate of burning calories, by about 4 times the normal rate. Another study showed that drinking matcha before exercise resulting in 25% more fat burning. Improving heart health. Green tea has been shown to lower LDL cholesterol, and lower incidence of heart disease and stroke in regular drinkers. (9) A recent Chinese study found that hypertension risk is lowered by up to 65 percent in regular green tea drinkers. Imagine the potential improvements to heart health in drinkers of the much more concentrated form of green tea that matcha is!   DETOX SUPPORT NUTRIENT #2 – Milk Thistle (Silybum marianum) Don't confuse this plant for a weed like most people do. It's a part of the artichoke family, a superfood known for its incredible support of the liver – your body's central detoxifier. In Germany, Milk Thistle is still prescribed today by doctors to treat alcoholic cirrhosis, hepatitis, jaundice, and any inflammation or poisoning of the liver.   Supports: Liver, Digestive Organs, and Lungs   DETOX SUPPORT NUTRIENT #3 – Blessed Thistle (Cnicus benedictus) Used for more than 2,000 years to stimulate appetite, support bile secretion, support liver health, this superfood is known for its support of your digestive system. Blessed thistle (Cnicus benedictus), not to be confused with milk thistle (Silybum marianum), was once used to treat the bubonic plague. It's still used today for natural digestive comfort and can even be applied to the skin to support wound healing.   Supports: Liver, Colon and Digestive System   DETOX SUPPORT NUTRIENT #4 – Licorice Root (Glycyrrhiza glabra) Licorice root is used to soothe gastrointestinal problems. In cases of food poisoning, stomach ulcers, and heartburn, licorice root extract can speed the repair of stomach lining and restore balance. This is due to the anti-inflammatory and immune-boosting properties of glycyrrhizic acid. Licorice is recommended to treat respiratory problems. Taking licorice as an oral supplement can help the body produce healthy mucus. Increasing phlegm production may seem counterintuitive to a healthy bronchial system. However, the opposite is true. The production of clean, healthy phlegm keeps the respiratory system functioning without old, sticky mucus clogging it.   Supports: Digestive System, Colon, Lungs   DETOX SUPPORT NUTRIENT #5 – Dandelion Root (Taraxacum officinale) You may be most familiar with dandelion as a stubborn weed that never seems to leave your lawn or garden. However, in traditional herbal medicine practices, dandelion are revered for their wide array of medicinal properties. For centuries, they've been used to treat a myriad of physical ailments, including cancer, acne, liver disease and digestive disorders. From root to flower, dandelion are highly nutritious plants, loaded with vitamins, minerals and fiber. Dandelion greens can be eaten cooked or raw and serve as an excellent source of vitamins A, C and K. They also contain vitamin E, folate and small amounts of other B vitamins. What's more, dandelion greens provide a substantial amount of several minerals, including iron, calcium, magnesium and potassium. The root of the dandelion is rich in the carbohydrate inulin, which is a type of soluble fiber found in plants that supports the growth and maintenance of a healthy bacterial flora in your intestinal tract. Dandelion are a rich source of beta-carotene and polyphenolic compounds, both of which are known to have strong antioxidant capabilities that can prevent aging and certain diseases. Animal studies have shown that dandelion protect liver tissue from toxic substances and oxidative stress. Some research indicates that dandelion may have antimicrobial and antiviral properties, which could support your body's ability to fight infection. Several test-tube studies found that dandelion extract significantly reduced the ability of viruses to replicate.   Supports: Colon, Liver, Digestive System   DETOX SUPPORT NUTRIENT #6 – Marshmallow Leaves (Althaea officinalis) Used by the ancient Greeks to remedy bruises and bleeding, and as a mild laxative. Europeans in medieval times used it for indigestion and diarrhea. And today it's still prescribed by doctors as a way to naturally soothe and support the intestines. Marshmallow leaves also have mild anti-infective and immune-supporting properties. That makes it perfect for gastroenteritis, peptic and duodenal ulcers, colitis, and enteritis.   Supports: Colon, Digestive System   Introducing: Organixx's NEW Organic Daily Detox Organic Daily Detox was designed specifically to boost your levels of these nutrients and feed your natural detox machine exactly what it needs to properly detox over the long run. The result? Better energy… Better sleep… Better ability to fight illness… And of course, a robust immune system you can depend on. Because Organixx is dedicated to the highest quality natural ingredients, a crystalized formula just made more sense. But there are other benefits as well. The first is potency. Most other detox “teas” just aren't made with enough quality ingredients to make any real difference to your health. They're watered down versions and are too weak to really do anything for you. The 2nd is freedom! With a traditional tea bag, you're forced to drink it as it is, with water. You're essential “bagged in” as I like to say and when your options are limited, you get bored quickly. But our specially formulated detox mix is perfect to be stirred into any of your other favorite drinks. It's made to mix easily so it's a perfect health boost in smoothies, juices or water. And because of the unique manufacturing process, any unneeded “filler” Liquids or compounds are extracted before it's turned into a crystalized format. It also makes Organic Daily Detox easier to drink. Simply take 1 or two scoops and drop it into hot or cold water. It mixes nearly instantly! Resources: Milk Thistle Benefits: 15 Ways This Super Herb Can Improve Your Health https://organixx.com/milk-thistle-benefits/?gl=60b8d78b8ebf583b0a3c207d Detox Your Liver Naturally! (+ 7 Tips for a Healthy Liver) https://organixx.com/liver-detox/?gl=60b8d78b8ebf58f1103c207f 11 Signs Your Body Is Screaming for a Detox https://www.foodmatters.com/article/the-importance-of-detoxifying-your-body Detoxification Pathways in the Liver http://link.springer.com/chapter/10.1007/978-94-011-9749-6_2 Chlorophyll and Chlorophyllin http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/chlorophyll-chlorophyllin Determination of catechins in matcha green tea by micellar electrokinetic chromatography. https://www.ncbi.nlm.nih.gov/pubmed/14518774 Tea and Cancer Prevention https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/tea-fact-sheet Effect of Green Tea Phytochemicals on Mood and Cognition. https://www.ncbi.nlm.nih.gov/pubmed/28056735 Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women. https://www.ncbi.nlm.nih.gov/pubmed/24993695 Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials. https://www.ncbi.nlm.nih.gov/pubmed/21715508 Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1 https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00670# Infections caused by Gram-positive bacteria: a review of the global challenge. https://www.ncbi.nlm.nih.gov/pubmed/19766888 Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders https://www.sciencedirect.com/science/article/pii/S0102695X14000477?via%3Dihub Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro https://www.sciencedirect.com/science/article/abs/pii/S0378874109006102?via%3Dihub Determination of Antioxidant Activity of Marshmallow Flower (Althaea officinalis L.) https://www.tandfonline.com/doi/abs/10.1081/AL-120039431 Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. https://www.ncbi.nlm.nih.gov/pubmed/19149749 Flavonoids--food sources and health benefits. https://www.ncbi.nlm.nih.gov/pubmed/25272572 Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886629/ Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492638/ Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/ Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120831/ Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention. https://www.ncbi.nlm.nih.gov/pubmed/25134454 Flavonoids, Inflammation and Immune System https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084045/ Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study. https://www.ncbi.nlm.nih.gov/pubmed/26367736 Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. https://www.ncbi.nlm.nih.gov/pubmed/2671116/ Hepatoprotective effect of silymarin. https://www.ncbi.nlm.nih.gov/pubmed/24672644 Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials. https://www.ncbi.nlm.nih.gov/pubmed/25208775 Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR. https://www.ncbi.nlm.nih.gov/pubmed/25644491 Isolation and Identification of Compounds from Bioactive Extracts of Taraxacum officinale Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents. https://www.ncbi.nlm.nih.gov/pubmed/29507587 Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. https://www.ncbi.nlm.nih.gov/pubmed/22078030 Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. https://www.ncbi.nlm.nih.gov/pubmed/24481875 Leaves Antimicrobial Activity of Glycyrrhiza glabra L. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870067/ An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123991/ Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715454/ 4 HUGE Matcha Green Tea Powder Benefits for Weight Loss, Detox & More! https://organixx.com/matcha-green-tea-powder/?gl=60b8d72e8ebf58f1103c207e Marshmallow: A Surprising Ingredient for Detox, the Gut, Respiratory Health & More https://organixx.com/marshmallow-plant-benefits/?gl=60b8d73a8ebf58f0103c207d

Your body is designed to remove toxins and waste on its own. But do you know how to support it? Tune in this week to learn how! We all have a Natural Detox Response. When we activate this response in our bodies, we increase our ability to protect your immune system naturally, and clear out the everyday toxins that find their way into your food, the air you breathe, the water you drink, and the surfaces you touch.   Natural Detox Response When we activate this response in our bodies we: Increase our ability to protect your immune system naturally clear out the everyday toxins that find their way into your food, the air you breathe, the water you drink, and the surfaces you touch Your body is designed to remove toxins and waste on its own. And while your organs are there to keep you alive, each and every one of them plays its own role in keeping you healthy. There are 4 organs more than any others that work together to create your personal detox machine working inside of you right now…   Your Liver acts like a filter in blocking out toxic substances in foods and drinks from passing into your bloodstream… Your Kidneys are working around the clock to then filter that blood and flush out those toxins when you use the bathroom. Your Colon puts in overtime taking care of the larger toxins and breaking them down with healthy bacteria before they can do you any harm… And Your Lungs play their part in filtering out the toxins that enter your body from breathing. As you can see, the human body was designed as a fully equipped detox machine.   How To Support Your ‘Detox Machine' You must take steps to support your body's Natural Detox Response System and I'm about to show you how right now… Once you begin to support your body's natural detox abilities, you'll notice that your body's “normal state” tends to shift toward health instead of inching toward illness. So what is it that your body needs to trigger your Natural Detox Response?   DETOX SUPPORT NUTRIENT #1 – Matcha   Matcha tea is the “it” health beverage of the moment, but this amazing superfood is more than just a “fad” trend. The history of matcha for health goes back to the Tang Dynasty in China, which ruled between the 7th – 10th centuries. Over time, the matcha tea made its way to Japan, where it began to be incorporated into special tea ceremonies. And today, countless scientific studies show us just how powerful this little nutrient is. First, it boosts chlorophyll levels. Chlorophyll can help improve liver function, which also boosts your body's ability to flush out toxins. So, it's no surprise that it's been shown to help with the excretion of heavy metals, dioxins, and other persistent chemicals, And the second part of the magic of matcha is big energy without the crash. Unlike the caffeine that comes from coffee beans, the caffeine in Matcha is released slowly into your system along with L-theanine, giving you a steady supply of energy so your body's natural detox system can function at its highest levels.   Other Benefits of Matcha: Protection against free radicals. You've heard about the antioxidant power of green tea, right? Well, matcha has 137 times more antioxidants than regular green tea! And 20 times more than a serving of blueberries. Antioxidants are key to disease prevention and are one of the best ways to boost your health. Cancer prevention. Catechins, which are potent cancer-fighters counteracting the effect of pollutants, chemicals, UV rays, and radiation, are a unique set of antioxidants found only in matcha. According to the National Cancer Institute, green tea is one of the most powerful cancer-fighters. Calm alertness. Matcha tea is rich in the amino acid L-Theanine, which is what left those Zen monks (and me) feeling calm, yet alert and focused. While it is a component of all green and black teas, matcha contains roughly five times the amount of L-theanine. Linked to increased concentration, learning ability and even physical endurance, L-Theanine gives you a boost without the caffeine jitters. (6) As someone who absolutely cannot handle the caffeine in coffee, matcha is my go to pick-me-up. If your clients or patients struggle with caffeine jitters, a cup of matcha might be a better choice. Anti-aging properties. A common drink in Okinawa, Japan, one of the few Blue Zones, where people live the longest, healthiest lives, matcha is said to reduce inflammation and oxidation, contributing to anti-aging. Fat-burning properties. One study found that matcha tea increased thermogenesis, the body's rate of burning calories, by about 4 times the normal rate. Another study showed that drinking matcha before exercise resulting in 25% more fat burning. Improving heart health. Green tea has been shown to lower LDL cholesterol, and lower incidence of heart disease and stroke in regular drinkers. (9) A recent Chinese study found that hypertension risk is lowered by up to 65 percent in regular green tea drinkers. Imagine the potential improvements to heart health in drinkers of the much more concentrated form of green tea that matcha is!   DETOX SUPPORT NUTRIENT #2 – Milk Thistle (Silybum marianum) Don't confuse this plant for a weed like most people do. It's a part of the artichoke family, a superfood known for its incredible support of the liver – your body's central detoxifier. In Germany, Milk Thistle is still prescribed today by doctors to treat alcoholic cirrhosis, hepatitis, jaundice, and any inflammation or poisoning of the liver.   Supports: Liver, Digestive Organs, and Lungs   DETOX SUPPORT NUTRIENT #3 – Blessed Thistle (Cnicus benedictus) Used for more than 2,000 years to stimulate appetite, support bile secretion, support liver health, this superfood is known for its support of your digestive system. Blessed thistle (Cnicus benedictus), not to be confused with milk thistle (Silybum marianum), was once used to treat the bubonic plague. It's still used today for natural digestive comfort and can even be applied to the skin to support wound healing.   Supports: Liver, Colon and Digestive System   DETOX SUPPORT NUTRIENT #4 – Licorice Root (Glycyrrhiza glabra) Licorice root is used to soothe gastrointestinal problems. In cases of food poisoning, stomach ulcers, and heartburn, licorice root extract can speed the repair of stomach lining and restore balance. This is due to the anti-inflammatory and immune-boosting properties of glycyrrhizic acid. Licorice is recommended to treat respiratory problems. Taking licorice as an oral supplement can help the body produce healthy mucus. Increasing phlegm production may seem counterintuitive to a healthy bronchial system. However, the opposite is true. The production of clean, healthy phlegm keeps the respiratory system functioning without old, sticky mucus clogging it.   Supports: Digestive System, Colon, Lungs   DETOX SUPPORT NUTRIENT #5 – Dandelion Root (Taraxacum officinale) You may be most familiar with dandelion as a stubborn weed that never seems to leave your lawn or garden. However, in traditional herbal medicine practices, dandelion are revered for their wide array of medicinal properties. For centuries, they've been used to treat a myriad of physical ailments, including cancer, acne, liver disease and digestive disorders. From root to flower, dandelion are highly nutritious plants, loaded with vitamins, minerals and fiber. Dandelion greens can be eaten cooked or raw and serve as an excellent source of vitamins A, C and K. They also contain vitamin E, folate and small amounts of other B vitamins. What's more, dandelion greens provide a substantial amount of several minerals, including iron, calcium, magnesium and potassium. The root of the dandelion is rich in the carbohydrate inulin, which is a type of soluble fiber found in plants that supports the growth and maintenance of a healthy bacterial flora in your intestinal tract. Dandelion are a rich source of beta-carotene and polyphenolic compounds, both of which are known to have strong antioxidant capabilities that can prevent aging and certain diseases. Animal studies have shown that dandelion protect liver tissue from toxic substances and oxidative stress. Some research indicates that dandelion may have antimicrobial and antiviral properties, which could support your body's ability to fight infection. Several test-tube studies found that dandelion extract significantly reduced the ability of viruses to replicate.   Supports: Colon, Liver, Digestive System   DETOX SUPPORT NUTRIENT #6 – Marshmallow Leaves (Althaea officinalis) Used by the ancient Greeks to remedy bruises and bleeding, and as a mild laxative. Europeans in medieval times used it for indigestion and diarrhea. And today it's still prescribed by doctors as a way to naturally soothe and support the intestines. Marshmallow leaves also have mild anti-infective and immune-supporting properties. That makes it perfect for gastroenteritis, peptic and duodenal ulcers, colitis, and enteritis.   Supports: Colon, Digestive System   Introducing: Organixx's NEW Organic Daily Detox Organic Daily Detox was designed specifically to boost your levels of these nutrients and feed your natural detox machine exactly what it needs to properly detox over the long run. The result? Better energy… Better sleep… Better ability to fight illness… And of course, a robust immune system you can depend on. Because Organixx is dedicated to the highest quality natural ingredients, a crystalized formula just made more sense. But there are other benefits as well. The first is potency. Most other detox “teas” just aren't made with enough quality ingredients to make any real difference to your health. They're watered down versions and are too weak to really do anything for you. The 2nd is freedom! With a traditional tea bag, you're forced to drink it as it is, with water. You're essential “bagged in” as I like to say and when your options are limited, you get bored quickly. But our specially formulated detox mix is perfect to be stirred into any of your other favorite drinks. It's made to mix easily so it's a perfect health boost in smoothies, juices or water. And because of the unique manufacturing process, any unneeded “filler” Liquids or compounds are extracted before it's turned into a crystalized format. It also makes Organic Daily Detox easier to drink. Simply take 1 or two scoops and drop it into hot or cold water. It mixes nearly instantly! Resources: Milk Thistle Benefits: 15 Ways This Super Herb Can Improve Your Health https://organixx.com/milk-thistle-benefits/?gl=60b8d78b8ebf583b0a3c207d Detox Your Liver Naturally! (+ 7 Tips for a Healthy Liver) https://organixx.com/liver-detox/?gl=60b8d78b8ebf58f1103c207f 11 Signs Your Body Is Screaming for a Detox https://www.foodmatters.com/article/the-importance-of-detoxifying-your-body Detoxification Pathways in the Liver http://link.springer.com/chapter/10.1007/978-94-011-9749-6_2 Chlorophyll and Chlorophyllin http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/chlorophyll-chlorophyllin Determination of catechins in matcha green tea by micellar electrokinetic chromatography. https://www.ncbi.nlm.nih.gov/pubmed/14518774 Tea and Cancer Prevention https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/tea-fact-sheet Effect of Green Tea Phytochemicals on Mood and Cognition. https://www.ncbi.nlm.nih.gov/pubmed/28056735 Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women. https://www.ncbi.nlm.nih.gov/pubmed/24993695 Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials. https://www.ncbi.nlm.nih.gov/pubmed/21715508 Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1 https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00670# Infections caused by Gram-positive bacteria: a review of the global challenge. https://www.ncbi.nlm.nih.gov/pubmed/19766888 Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders https://www.sciencedirect.com/science/article/pii/S0102695X14000477?via%3Dihub Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro https://www.sciencedirect.com/science/article/abs/pii/S0378874109006102?via%3Dihub Determination of Antioxidant Activity of Marshmallow Flower (Althaea officinalis L.) https://www.tandfonline.com/doi/abs/10.1081/AL-120039431 Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. https://www.ncbi.nlm.nih.gov/pubmed/19149749 Flavonoids--food sources and health benefits. https://www.ncbi.nlm.nih.gov/pubmed/25272572 Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886629/ Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492638/ Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/ Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120831/ Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention. https://www.ncbi.nlm.nih.gov/pubmed/25134454 Flavonoids, Inflammation and Immune System https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084045/ Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study. https://www.ncbi.nlm.nih.gov/pubmed/26367736 Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. https://www.ncbi.nlm.nih.gov/pubmed/2671116/ Hepatoprotective effect of silymarin. https://www.ncbi.nlm.nih.gov/pubmed/24672644 Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials. https://www.ncbi.nlm.nih.gov/pubmed/25208775 Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR. https://www.ncbi.nlm.nih.gov/pubmed/25644491 Isolation and Identification of Compounds from Bioactive Extracts of Taraxacum officinale Weber ex F. H. Wigg. (Dandelion) as a Potential Source of Antibacterial Agents. https://www.ncbi.nlm.nih.gov/pubmed/29507587 Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. https://www.ncbi.nlm.nih.gov/pubmed/22078030 Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. https://www.ncbi.nlm.nih.gov/pubmed/24481875 Leaves Antimicrobial Activity of Glycyrrhiza glabra L. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870067/ An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123991/ Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715454/ 4 HUGE Matcha Green Tea Powder Benefits for Weight Loss, Detox & More! https://organixx.com/matcha-green-tea-powder/?gl=60b8d72e8ebf58f1103c207e Marshmallow: A Surprising Ingredient for Detox, the Gut, Respiratory Health & More https://organixx.com/marshmallow-plant-benefits/?gl=60b8d73a8ebf58f0103c207d

Recorded February 12, 2021Current Episodes at https://walkinverse.buzzsprout.com/I am moving all podcast here slowly. I will keep buzzsprout for all public reports and here for member only content.Report #37, "Gates, Fauci, and Operation Warp Speed: It's All About Connections." In the last report, we reviewed the mRNA experimental injectable technology. Now we will show a few connections behind it. Grab a pen and notebook and enjoy the report.In the last report, we reviewed the mRNA experimental injectable technology. Now we will show a few connections behind it.To date, health officials claim the novel COVID-19 soars past 16.2 million cases for a virus with a 99.9% survival rate. To justify case count, they continue to use a test proven to produce false positives. This immoral act allows for compliance through fear as these elites can accelerate their agenda without resistance.But before we dig further, please hear these words and wipe the dread from your mind. We will prevail once we remove our eyes from man and place them on the Almighty.And as stated in Isaiah 35:3-5, we have nothing to fear.“Strengthen the weak hands, And make firm the feeble knees. 4 Say to those who are fearful-hearted, “Be strong, do not fear! Behold, your God will come with vengeance, With the recompense of God; He will come and save you.” 5 Then the eyes of the blind shall be opened, And the ears of the deaf shall be unstopped.”Isa 35:3-5With those words in mind, let's view the network which drives the mRNA agenda.Many question why government officials and healthcare providers push an experimental genome therapy labeled a vaccine. They realize it causes illness and death. They have no discernment of long or short-term side effects. And yet, the answer lies before us. Massive financial gain and control for continuous revenue streams at our expense.In an interview, Bill Gates boasted how the vaccine industry returned a 20-1 investment. This statement shows how these elites play for keeps. They do not have our well-being in mind (1).And soon, a Gates-backed (2) firm will release 200 million vaccine kits and millions of experimental injections for vaccination against a coronavirus, aka a common cold.Back in May, Korea's S.K. Bioscience pharmaceutical company received $3.6 million in research funds from the Gates Foundation to support the development of a COVID-19 vax. This same company works as a contract manufacturer for AstraZeneca, which received $750 million from CEPI and GAVI (3) back in June 2020 to support the manufacturing, procurement, and distribution of mRNA injectable technology. In addition, AstraZeneca agreed to supply 1-Billion doses to low and mid-income nations. On top of these quantities, they announced a supply of 400 million doses ready for the E.U. And all the while, under the cover of night, the Imperial College steps into the vaccine game. They plan on another variation by the first half of 2021. Will it work? They have no clue. Professor Robin Shattock (4), the head of the vaccine development team at the University of Imperial College, stated, “We anticipate if everything goes really well, that we'll get an answer as to whether it works by early next year.”Professor Shattock is from the same Imperial College where Neil Ferguson used his fraudulent models to lock the world down (5) through data manipulation. He used invalid inputs based on early estimates. He selected outdated demographics, populations, and hospital bed counts to inflate numbers artificially. Instead of data from specific states to gather credible metrics, his models used the entire U.S. to drive COVID-19 spread. This skyrocketed infection rates and fears, as the model assumed everyone spreads the disease at the same rate—for virus spread detection, it's an outright scam and a crime against humanity. Yet, he still roams free without consequence. Why?The answer lies in the secure funds received from the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, MRC, and the NIH (Anthony Fauci), which indicates the degree of corruption imposed upon humanity for long term profits.And when we look to NIH and Fauci, we witness extended deception with their ties to Moderna (6). With the mRNA-1273 experiment, the U.S. government appears to have joint ownership through filed patents. With $472 million secured, Moderna plans to reach its target of 500 million doses per year, with a ramp-up to one billion in 2021. Also, (7) DARPA joins Moderna to develop an implantable biochip for the deployment of experimental therapies, which can affect human DNA.But at (8) $19.50 per dose, subsidized by taxpayers, does it matter? It's all about people over profits, which circles us back to GAVI, the WHO, CEPI, and Trump's Operation Warp Speed.Trump pulled finances (9) from the WHO, which everyone cheered as he handed it over to GAVI, the Vaccine Alliance. What most may not realize, Gates and his foundation founded GAVI in 2000 (10). So when Trump pledged $1.16 billion at the virtual Global Vaccine summit, this became part of the Fiscal budget for 2020-2023, which solidified the fact he did not have the American people's best interest in mind. Instead, he increased the hold Bill Gates has on the U.S. population and their health.At the summit, Gates stated, “Since its inception GAVI has helped vaccinate more than three-quarters of a billion children … And now, it's stepping up and saying it's willing to deliver a COVID-19 vaccine as soon as one is available to end the pandemic as soon as possible, … We must also renew our commitment to delivering every life-saving vaccine there is to every child on earth.”In addition, GAVI received a donation of $5 million from the Rockefeller Foundation for “routine immunization programs” and “play a major role in the rollout of a future COVID-19 vaccine.” which aligns with their playbook, Operation Lockstep (11).On top of this, who did Trump put at the helm of Operation Warp Speed? Another Gates connection, a former executive of GlaxoSmithKline, Moncef Slaoui. His role? Work hand in hand with General Gustave Perna for the production and vaccination across the United States.Now we'll look at CEPI, Operation Warp Speed, and Novavax. In 2017 Gates co-founded, “The Coalition for Epidemic Preparedness Innovations (CEPI)” (12) to stop epidemics via vaccines. It's the largest vaccine charity in the world. They made their mark across mainstream when they granted $388 million to an unknown biotech company, Novavax. Another company to fill the world with mRNA injections for COVID-19 (Certificate of Vaccine Identification – Artificial [1] Intelligence [9]). In a move that baffled many, Operation Warp Speed (12) also selected this company and awarded them $1.6 billion in taxpayers' funds. So while the people of the United States have their rights revoked and business destroyed at astronomical rates, the Trump administration gave your future away to Gates for an injection never used or tested on humans.And all the while, the media, Fauci, Gates, social media companies, politicians, and others lied outright to the people about HCQ (13). They knew it worked from day one. But as we see from facts, Big Pharma revenue streams and kickbacks outweighed our health.Instead of protecting people's lives, our officials schemed with these monsters behind closed doors to push an experiment to alter your DNA (14). As learned in Professor Klungland's research, “RNA has a direct effect on DNA stability.” He notes how several research groups collaborate to understand the effects this can have on the DNA molecule. He stated, “We already know that R-loop areas are associated with sequences of DNA containing active genes and that this can lead to chromosomal breakage and the loss of genetic information…” This reveals absolute modification, regardless of what the fake fact-checkers, mainstream, social media channels, or Fauci's pundits claim.To drive this point one step further, we look to the National Cancer Institute for clarification (15). Through research, they learned modification in human mRNA affects gene expression, “NAT10, an enzyme, was found to be responsible for the modification, which itself has been implicated in cancer and aging. This is one of the first examples of a unique chemical modification to mRNA…”To date, these companies refuse doctors and researchers the information required to learn the effects these synthetic drugs have on the human body. But it looks like another revenue stream in cancer therapies with the chemical modification seen in these experiments.And while the PREP Act combined with the unlawful classification of mRNA as a vaccine, these corporations have 100% immunity from all legal action (8) while they engage in an experiment without the people's informed consent (16) — a process which requires compliance or rejection of a medical procedure such as surgeries, anesthesia, radiation, chemotherapy, vaccination, and other scenarios.These experimental war crimes continue under the guise of trials (17), “A new vaccine trial is underway in the U.K. to test whether mixing and matching different COVID-19 vaccines for the first and second doses is effective,” they continue, “The country is currently using the Pfizer-BioNTech vaccine and Oxford-AstraZeneca vaccine, which both require two doses. For the study, run by the National Immunization Schedule Evaluation Consortium, patients will get one dose of each.”Remember, they never approved mRNA technologies for human use. These professionals for profit don't know or care about the long or short term side effects. To further prove these drugs still exist in the experimental stage, Moderna started on July 27, 2020, and will end on October 27, 2020, as noted by the study (18), “A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19.” Pfizer (19) began their test on humanity on April 29, 2020, with a target primary completion on August 3, 2021, and the experiment to end on January 21, 2023, as noted in the “Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals.”With each injection, they test their poisons on an ill-informed public. And due to PREP, if you or your loved one becomes injured or dies from these jabs, you have zero recourse. Without informed consent, all involved in administration, production, delivery, and procurement—guilty of war crimes against humanity as stated in the Nuremberg Code (20), “The voluntary consent of the human subject is absolutely essential.” No bribes or coercion—all the facts known beforehand. For those front line workers, LEO, Military, Politicians who follow orders, no excuse. During the trials of Nuremberg, ignorance did not afford reprieve from the consequences of their willful actions. They knew and still tested on humans without consent (21).“THE PROOF AS TO WAR CRIMES AND CRIMES AGAINST HUMANITYJudged by any standard of proof the record clearly shows the commission of war crimes and crimes against humanity substantially as alleged in counts two and three of the indictment. Beginning with the outbreak of World War II criminal medical experiments on non-German nationals, both prisoners of war and civilians, including Jews and “asocial” persons, were carried out on a large scale in Germany and the occupied countries. These experiments were not the isolated and casual acts of individual doctors and scientists working solely on their own responsibility, but were the product of coordinated policy-making and planning at high governmental, military, and Nazi Party levels, conducted as an integral part of the total war effort. They were ordered, sanctioned, permitted, or approved by persons in positions of authority who under all principles of law were under the duty to know about these things and to take steps to terminate or prevent them.”Sounds familiar?When Governments (8) and officials receive kickbacks and taxpayers fund Big Pharma experiments with no legal ramifications, it no longer about one health. It's all profits.The time's at hand to end this experiment, or they will end us—no more compliance.There are more of us than them.References* Freedom Lovers TV. 2020. Bill Gates Confesses Vaccines Are His Best Investment w/ ROI of 20 to 1.* Soo Kim. 2020. “Coronavirus Vaccine Update as Bill Gates-Backed Firm Could Make 200 Million Kits a Year.” Newsweek, July 27, 2020, sec. News.* Staff. 2020. “AZD1222 SARS-CoV-2 Vaccine.” Precision Vax. December 6, 2020.* Imperial College. n.d. “Professor Robin Shattock.”* Osburn, Madeline. 2020. “Inaccurate Virus Models Are Panicking Officials Into Ill-Advised Lockdowns.” The Federalist. March 25, 2020.* Patrick Howley. 2020. “BUSTED: NIH Owns Financial Stake In Gates-Funded Coronavirus Vaccine.” National File (blog). June 29, 2020.* Franz Walker. 2020. “DARPA Funded Implantable Biochip Can Potentially Be Used to Deploy Moderna's MRNA Vaccine.” Nanotechnology News. October 12, 2020.* Apuzzo, Matt, and Selam Gebrekidan. 2021. “Governments Sign Secret Vaccine Deals. Here's What They Hide.” The New York Times, January 28, 2021, sec. World.* Broze, Derrick. 2020. “Vaccine Bait & Switch: As Millions Pulled From WHO, Trump Gives Billions To Gates-Founded GAVI.” The Last American Vagabond (blog). July 7, 2020.* The Bill & Melinda Gates Foundation [Internet]. [cited 2021 Feb 9]. Available from: https://www.gavi.org/investing-gavi/funding/donor-profiles/bill-melinda-gates-foundation* N/A. Operation Lockstep: From The Rockefeller Playbook [Internet]. Shadaily. 2020 [cited 2020 Dec 7].* Carmichael, Taylor. 2020. “Why Was Novavax Awarded Almost $2 Billion in Free Money?” The Motley Fool. July 22, 2020.* Patrick Howley. 2020. “EXPOSED: The Truth About Fauci and Birx, Bill Gates And Globalist Elites.” National File. March 26, 2020.* Eyrun Thune. 2020. “Modified RNA Has a Direct Effect on DNA.” PHYS.ORG. January 29, 2020.* NIH. 2018. “A Novel MRNA Modification May Impact the Human Genetic Code.” Center for Cancer Research. November 15, 2018.* Kirsten Nunez. 2019. “Informed Consent in Healthcare: What It Is and Why It's Needed.” Healthline. October 11, 2019.* O'Kane, Caitlin. 2021. “U.K. Study Will Test If Getting Doses of Two Different COVID-19 Vaccines Is Effective.” CBS News. February 4, 2021.* ModernaTX, Inc. 2020. “A Phase 3, Randomized, Stratified, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of MRNA-1273 SARS-CoV-2 Vaccine in Adults Aged 18 Years and Older.” Clinical trial registration NCT04470427. clinicaltrials.gov.* BioNTech SE. 2021. “Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals.” Clinicaltrials.Gov. February 9, 2021.* Government. 2020. “THE NUREMBERG CODE.” February 16, 2020.* Government. 1949. “TRIALS  OF WAR CRIMINALS  BEFORE THE  NUERNBERG MILITARY TRIBUNALS  UNDER  CONTROL  COUNCIL LAW No. 1.” 1949. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit walkinverse.substack.com/subscribe

Sobre Cetamina - Ep 2 E a cetamina intranasal, o Spravato? Infusão de conhecimento Aviso: Este é um podcast para médicos sob responsabilidade do Dr. Tiago Gil, médico anestesista CRMSP 157384 RQE 64871 A medicina é uma ciência que está em evolução e este podcast não deve ser utilizado como guia terapêutico. Esse episódio foi gravado como verdade até julho de 2020 Meu email é contato@cetamina.com e em varias redes sociais como “centro de cetamina” No episódio eu disse que não tem nenhum estudo comparando a cetamina endovenosa com a intranasal uma a uma, mas existe um estudo que fez uma revisão de literatura para comparar as duas e a conclusão foi que a endovenosa é mais eficaz do que a intranasal, veja só: A. Bahji, G. H. Vazquez, and C. A. Zarate, “Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis,” J. Affect. Disord., vol. 278, pp. 542–555, 2021. https://doi.org/10.1016/j.jad.2020.09.071 Referências Bibliográficas: [1] F. Carlos A. Zarate, Jr, MD; Jaskaran B. Singh, MD; Paul J. Carlson, MD; Nancy E. Brutsche, MSN; Rezvan Ameli, PhD; David A. Luckenbaugh, MA; Dennis S. Charney, MD; Husseini K. Manji, MD, “A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression,” Arch. Gen. Psychiatry, vol. 63, pp. 856–864, 2006. [2] J. B. Singh et al., “Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study,” Biol. Psychiatry, vol. 80, no. 6, pp. 424–431, 2016. [3] J. B. Singh et al., “A double-blind, randomized, placebo-controlled, dose-frequency study of intravenous ketamine in patients with treatment-resistant depression,” Am. J. Psychiatry, vol. 173, no. 8, pp. 816–826, 2016. [4] E. J. Daly et al., “Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: A randomized clinical trial,” JAMA Psychiatry, vol. 75, no. 2, pp. 139–148, 2018. [5] FDA, “Efficacy, safety, and risk-benefit profile of New Drug Application (NDA) 211243, esketamine 28 mg single-use nasal spray device for the treatment of treatment-resistant depression,” pp. 1–135, 2019. [6] S. H. Kennedy et al., “Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 3. Pharmacological Treatments,” Canadian Journal of Psychiatry, vol. 61, no. 9. SAGE Publications Inc., pp. 540–560, 2016.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.27.063560v1?rss=1 Authors: Rawji, V., Rocchi, L., Foltynie, T., Rothwell, J. C., Jahanshahi, M. Abstract: Response inhibition describes the cognitive processes mediating the suppression of unwanted actions. A network involving the basal ganglia mediates two forms of response inhibition: reactive and proactive inhibition. Reactive inhibition serves to abruptly stop motor activity, whereas proactive inhibition is goal-orientated and results in slowing of motor activity in anticipation of stopping. Due to its impairment in several psychiatric disorders, the neurochemistry of response inhibition has become of recent interest. Dopamine has been posed as a candidate mediator of response inhibition due to its role in functioning of the basal ganglia and the observation that patients with Parkinson's disease on dopamine agonists develop impulse control disorders. Although the effects of dopamine on reactive inhibition have been studied, substantial literature on the role of dopamine on proactive inhibition is lacking. To fill this gap, we devised a double-blind, placebo-controlled study of 1 mg ropinirole (a dopamine agonist) on response inhibition in healthy volunteers. We found that whilst reactive inhibition was unchanged, proactive inhibition was impaired when participants were on ropinirole relative to when on placebo. To investigate how ropinirole mediated this effect on proactive inhibition, we used hierarchical drift-diffusion modelling. We found that ropinirole impaired the ability to raise the decision threshold when proactive inhibition was called upon. Our results provide novel evidence that an acute dose of ropinirole selectively reduces proactive inhibition in healthy participants. These results may help explain how ropinirole induces impulse control disorders in susceptible patients with Parkinson's disease. Copy rights belong to original authors. Visit the link for more info