Podcasts about amelioration

Ce vendredi 3 janvier, la projection du prix du pétrole pour 2025 et l'amélioration de la productivité avec l'IA générative ont été abordées par Jean-Marc Daniel, éditorialiste BFM Business, Philippe Aghion, professeur au Collège de France, et Augustin Landier, professeur à HEC, dans l'émission Les Experts, présentée par Nicolas Doze sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

In this episode of the MSF Farm Talk podcast, host Nick Paltridge sits down with Dr Stephen Davies, Principal Research Scientist at the Department of Primary Industries and Regional Development (DPIRD), to discuss soil amelioration practices in Western Australia. Stephen, who has over 20 years of experience working in the Northern Greenbelt of WA, shares insights into tackling soil challenges like water-repellent sands through deep ripping, mouldboard ploughing, spading, and more. This episode provides practical advice, the evolution of WA soil management techniques, and the impact of various methods on soil health and crop yield, acknowledging that much of the work discussed on the podcast is the result of joint investment across a number of projects by DPIRD and GRDC.  Stay tuned for part two, where the discussion continues into more agronomic decisions crucial for successful soil amelioration. 00:00 Introduction to Soil Amelioration 00:17 Stephen Davies' Background and Experience 00:50 Challenges and Solutions in Soil Management 03:49 Deep Ripping and Soil Inversion Techniques 05:42 Adoption and Impact of Soil Amelioration 09:46 Strategic Tillage and Long-Term Benefits 14:36 Balancing Tillage with Sustainability 17:29 Conclusion and Future Prospects Useful links from Dr Stephen Davies work Agronomy Conference 2024 paper Crop establishment following amelioration PDF Follow Dr Stephen Davies on X @SteveDsoilsciWA This podcast was brought to you but the Australian Government's Future Drought Fund projects ‘Extension and Adoption of Drought Farming Practices' and ‘De-risking the seeding program - Adoption of key management practices for the success of dry early sown crops'.Support the show: https://msfp.org.au/about/membership/See omnystudio.com/listener for privacy information.

In part two of the MSF Farm Talk podcast featuring Dr. Stephen Davies, Principal Research Scientist at DPIRD in WA, the focus is on agronomy practices following soil amelioration. The discussion covers methods for effective crop establishment, seeding techniques, and the use of longer coleoptile wheat varieties to improve productivity on freshly ameliorated soils. Dr. Davies also shares insights into the challenges and strategies for managing these soils to ensure successful crop growth. The episode wraps up with considerations on seed rates and the benefits of strategic planning for future planting seasons. We would like to acknowledge that much of the work discussed on the podcast is the result of joint investment across a number of projects by DPIRD and GRDC.  00:00 Introduction and Recap of Part One 00:28 Agronomy After Amelioration 00:50 Crop Establishment Strategies 03:17 Seeding Techniques and Equipment 05:12 Long Coleoptile Wheat Benefits 08:04 Challenges and Solutions in Crop Establishment 10:09 Conclusion and Future Insights This podcast was brought to you but the Australian Government's Future Drought Fund project ‘Extension and Adoption of Drought Farming Practices' and ‘De-risking the seeding program - Adoption of key management practices for the success of dry early sown crops'.Support the show: https://msfp.org.au/about/membership/See omnystudio.com/listener for privacy information.

Join host Paige Cross and Weed Smart agronomist Chris Davey (CD) in this episode of the MSF Farm Talk Podcast as they discuss the GRDC field day focused on optimising soil amelioration efficiency. CD explores how weeds can indicate underlying soil health issues and shares various soil amelioration techniques to mitigate weed pressure. The conversation also touches on crop competition, soil health improvement strategies, and considerations for future growing seasons, particularly in the context of dry conditions. This episode is full of practical advice for long-term weed management and crop success. 00:00 Introduction to MSF Farm Talk Podcast 00:52 Exploring Soil Amelioration Techniques 01:33 Understanding Soil Health Through Weeds 05:08 Strategies for Soil Amelioration and Weed Management 11:11 Considerations for Dry Seasons and Future Planning 14:50 Conclusion and Final Thoughts This podcast was brought to you by the GRDC NGN project 'Optimising soil amelioration costs in typical Mallee soils'.  Support the show: https://msfp.org.au/about/membership/See omnystudio.com/listener for privacy information.

In this episode, Tim Smythe from Mallee Sustainable Farming and Jack Desbiolles from the University of South Australia's Agriculture, Machinery, Research and Design Centre discuss their pioneering work on strip amelioration. This technique involves alternating strips of ameliorated soil and undisturbed standing stubble, offering a flexible, erosion-reducing solution for high-risk crops like pulses in the Mallee. They delve into the machinery developed for this process and its impact on erosion control and crop yields, sharing insights from trials and future pathways for broad adoption. 00:00 Introduction to Strip Amelioration 00:55 Meet the Experts: Tim Smythe and Jack Desbiolles 01:11 Machinery Innovations for Strip Amelioration 03:42 Field Trials and Results 08:15 Challenges and Future Directions 13:29 Pathway to Adoption and Future Research 19:01 Conclusion and Acknowledgements This podcast has been brought to you as part of the ‘Developing robust ground cover to enable resilience in low rainfall mixed farms' project through funding from the Australian Government's Future Drought Fund. For more info click hereSupport the show: https://msfp.org.au/about/membership/See omnystudio.com/listener for privacy information.

Aktywność fizyczna wspaniale wspiera zdrowie i mamy na to coraz więcej niepodważalnych dowodów. Regularny ruch jest pomocny w profilaktyce niektórych chorób przewlekłych, m.in. chorób układu krążenia, cukrzycy, nowotworów, otyłości i depresji. Zatem aktywność fizyczna powinna być filarem dbania o długie życie w zdrowiu. Niestety, jako społeczeństwo wciąż za mało się ruszamy. W jaki sposób możemy to zmienić i jak wykorzystywać dobroczynne działanie aktywności w praktyce? Czy można przedawkować aktywność fizyczną? Na te i inne pytania odpowiemy w dzisiejszym odcinku. Moim dzisiejszym gościem jest Marek Fischer - absolwent dietetyki na Wydziale Nauk o Zdrowiu Pomorskiego Uniwersytetu Medycznego, konsultant żywieniowy i szkoleniowiec. Jego filozofią zawodową jest: „Personalizacja diety to podstawa. Jeśli szukasz modnej diety – idź do Empiku”. Marek jest autorem wielu artykułów w czasopismach branżowych oraz pełni rolę redaktora merytorycznego w Body Challenge, gdzie odpowiada za warstwę merytoryczną tekstów oraz dobór autorów. Był wykładowcą na wielu konferencjach żywieniowych oraz treningowych, w tym międzynarodowych. Marka znajdziecie na instagramie pod nickiem @fitmaker_fischer oraz stronie www.fitmakerfischer.com. Odcinek podcastu jest wspierany przez markę Kogen, która czerpie inspirację z japońskiej filozofii troski o zdrowie oraz łączy naturę z osiągnięciami nauki. Marka Kogen tworzy zaawansowane nutraceutyki, które skutecznie wspierają organizm w radzeniu sobie z wyzwaniami współczesnego życia. Z kodem DRKARABIN otrzymasz 10% zniżki na produkty w sklepie Kogen: https://kogen.pl/sklep/ Lista publikacji o których wspominamy w podcaście: Link do filmu “Jak ruchem zmienić umysł?” https://www.youtube.com/watch?v=AA-3DA5BWBs&ab_channel=FundacjaVeritas https://www.who.int/news-room/fact-sheets/detail/physical-activity Warburtonn D.E.R. i wsp.Health benefits of physical activity: the evidence.CMAJ. 2006 Mar 14;174(6):801-9.  Moyers S.A. i Hagger M.S. Physical activity and cortisol regulation: A meta-analysis. Biol Psychol. 2023 Apr:179:108548. Gao Y. i wsp. Enhanced muscle activity during interrupted sitting improves glycemic control in overweight and obese men. Randomized Controlled Trial Scand J Med Sci Sports. 2024 Apr;34(4):e14628.  Meta-Analysis Eur J Prev Cardiol Banach M. i wsp.The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis. 2023 Dec 21;30(18):1975-1985.  Nishihira J. i wsp. Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee. J. Funct. Foods. 2009;1(4):341–348. https://www.ais.gov.au/nutrition/supplements Nishizawa M. i wsp. Supplementation with a flavanol-rich lychee fruit extract influences the inflammatory status of young athletes. Randomized Controlled Trial Phytother Res. 2011 Oct;25(10):1486-93. Kawamura A. i wsp. Oligomerized polyphenols in lychee fruit extract supplements may improve high-intensity exercise performance in male athletes: a pilot study. Phys Act Nutr. 2021 Sep;25(3):8-15.  Ten materiał nie stanowi zamiennika wizyty lekarskiej. Nie jest też poradą zdrowotną, ani nie służy do diagnozowania ani leczenia chorób. Materiał ma charakter wyłącznie edukacyjny. Autorka nie ponosi odpowiedzialności za sposób wykorzystania przedstawionych informacji. 0:00 Intro 0:37 - Wstęp 02:38 - O filmie “Jak ruchem zmienić umysł?” 04:40 - Jaki wpływ na zdrowie ma aktywność fizyczna? 14:48 - Ile powinniśmy się ruszać, by wspierać zdrowie? 18:00 - Czy musimy robić 10 000 kroków dziennie? 22:35 - Jak często sięgać po aktywność siłową? 28:18 - Jak wplatać do swojego życia więcej aktywności fizycznej? 35:19 - Czy można przedawkować aktywność fizyczną? 42:31 - Czy aktywność fizyczna podnosi kortyzol? 49:11 - Dieta a aktywność fizyczna. Czy można ćwiczyć na czczo? 57:53 - Jakie suplementy mogą wesprzeć nas w codziennej aktywności fizycznej?

Liczba osób zmagających się z nadmierną masą ciała, otyłością czy cukrzycą rośnie w zastraszającym tempie. Śmiało możemy mówić już o epidemii chorób metabolicznych, które dotykają coraz młodsze osoby. Dlaczego tak się dzieje? Czy problem ten dotyczy tylko osób z nadmierną masą ciała? Jaki związek z chorobami metabolicznymi ma insulinooporność? Jak styl życia wpływa na powstawanie tych chorób? Na te i inne pytania odpowiemy w dzisiejszym odcinku. Moim dzisiejszym gościem jest Marek Fischer - absolwent dietetyki na Wydziale Nauk o Zdrowiu Pomorskiego Uniwersytetu Medycznego, konsultant żywieniowy i szkoleniowiec. Jego filozofią zawodową jest: „Personalizacja diety to podstawa. Jeśli szukasz modnej diety – idź do Empiku”. Marek jest autorem wielu artykułów w czasopismach branżowych oraz pełni rolę redaktora merytorycznego w Body Challenge, gdzie odpowiada za warstwę merytoryczną tekstów oraz dobór autorów. Był wykładowcą na wielu konferencjach żywieniowych oraz treningowych, w tym międzynarodowych. Marka znajdziecie na instagramie pod nickiem @fitmaker_fischer oraz stronie www.fitmakerfischer.com. Odcinek podcastu jest wspierany przez markę Kogen, która czerpie inspirację z japońskiej filozofii troski o zdrowie oraz łączy naturę z osiągnięciami nauki. Marka Kogen tworzy zaawansowane nutraceutyki, które skutecznie wspierają organizm w radzeniu sobie z wyzwaniami współczesnego życia. Z kodem DRKARABIN otrzymasz 10% zniżki na produkty w sklepie Kogen: https://kogen.pl/sklep/ Lista publikacji o których wspominamy w podcaście: https://www.who.int/news-room/fact-sheets/detail/diabetes https://pacjent.gov.pl/artykul/cukrzyca-w-liczbach Dobrowolski P. i wsp. Zespół metaboliczny — nowa definicja i postępowanie w praktyce. Nadciśnienie Tętnicze w Praktyce 2022, 8, 2: 1–26 Bąk‑Sosnowska M. i wsp. Zalecenia kliniczne dotyczące postępowania u chorych na otyłość 2022 – stanowisko Polskiego Towarzystwa Leczenia Otyłości. Med. Prakt. wyd. specj.; maj 2022: 1–8717. Sourya A. i  Samarth S. Metabolic Healthy Obesity-A Paradoxical Fallacy? Journal of Clinical and Diagnostic Research, 2018, 12(10), OE07-OE10. Soriguer F. i wsp. Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study. J Clin Endocrinol Metab 2013, 98, 2318-2325. Ruscica M. i wsp. Impact of nutraceuticals on markers of systemic inflammation: Potential relevance to cardiovascular diseases - A position paper from the International Lipid Expert Panel (ILEP). Prog Cardiovasc Dis. 2021 Jul-Aug;67:40-52. Sakurai T. i wsp. Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes. Biosci. Biotechnol. Biochem. 2008;72(2):463–476. Nishihira J. i wsp. Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee. J. Funct. Foods. 2009;1(4):341–348. Ten materiał nie stanowi zamiennika wizyty lekarskiej. Nie jest też poradą zdrowotną, ani nie służy do diagnozowania ani leczenia chorób. Materiał ma charakter wyłącznie edukacyjny. Autorka nie ponosi odpowiedzialności za sposób wykorzystania przedstawionych informacji. 0:00 Intro  0:37 - Wstęp 03:10 - Czym są zaburzenia metaboliczne i dlaczego przyjmują postać epidemii? 06:37 - Czym jest insulinooporność i co jest jej przyczyną? 17:52 - Czy warto ograniczać węglowodany w diecie? 20:47 - Czy możemy obwiniać producentów żywności o wzrost liczby chorób metabolicznych? 22:51 - Wpływ aktywności fizycznej na choroby metaboliczne 27:37 - Czym jest zespół metaboliczny? 34:57 - Czy tkanka tłuszczowa zawsze musi świadczyć o patologii? 45:15 - Czynniki wpływające na powstawanie chorób metabolicznych 52:14 - Nawyki żywieniowe a zaburzenia metaboliczne 59:21 - Czy istnieje dieta, która może poprawić nasze zdrowie metaboliczne? 01:09:43 - Polifenole a zaburzenia metaboliczne

Ce lundi 12 février, l'IA dans les jeux vidéo qui apporte des améliorations a été abordé par Mélinda Davan-Soulas dans sa chronique Culture Geek, dans l'émission Good Morning Business, présentée par Laure Closier et Christophe Jakubyszyn, sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

Almost six million hectares of WA's sand-plain soils in the medium and high-rainfall zones feature multiple constraints, including water repellence, acidity, and compaction. An estimated 250,000 hectares of those six million have been ameliorated, typically involving strategic one-off deep tillage. A GRDC investment is helping to determine the longevity benefits following soil amelioration, looking at crop rotations, species choice and seedbed preparation. We hear from Dr. Stephen Davies from WA's Department of Primary Industries and Regional Development, on the project's initial findings.  Download the transcript for this episode Contact: Stephen Davies DPIRD stephen.davies@dpird.wa.gov.au    More information: How does soil amelioration affect weed management? Unlocking WA soils' potential: Maintaining benefits of soil amelioration GRDC Code: DAW1901-006RTX Learn more about your ad choices. Visit megaphone.fm/adchoices

"Hitler was a product of his time," historian Kent Gardner told us in 1975, just thirty years after the end of World War II. "Was Frank Rizzo racist, or just a product of his time?" The Philadelphia Inquirer pondered in 2017 about the city's notoriously racist former police commissioner and mayor just 26 years after his death. "Christopher Columbus, no saint, was product of his time," explained a 2013 commentary in the Staten Island Advance. We often hear this sentiment in reference to historical atrocities. Slaveowners, colonizers, genocidal tyrants, and right-wing bigots from decades or centuries past didn't know any better. They were simply responding to the time and place in which they lived — a different time, marked by different social mores, moral standards, and laws. While it's perhaps fair to cite this cliche to explain, rather than justify, awkward song lyrics or offensive language and stereotypes used in movies from decades ago. But it's an entirely different issue with respect to how we venerate and remember the past. Especially since, in the most popular cases, famous people's bad actions were roundly criticized, at the time. Long popular as a catch-all to hand-wave away the misdeeds of slaveowners, colonizers and war mongers, Increasingly educational movements on the American right––from Ron DeSantis trying to remake history education to conservative propaganda targeting kids like PragerU — this "product of its time" cliché and its close cousin "don't judge the past by the standards of today" is making a bit of comeback, if it ever went away at all. The defensive, superficially appealing cliche is a popular go-to for those who think we shouldn't criticize the supposedly sacrosanct secular deities of our past — from George Washington to Ronald Reagan. But the whole concept operates under a glaring double standard: how can we take pride in and venerate the supposedly good things Americans in history did but ignore and dismiss the bad things? How can we pick and choose our moral inheritance at will? How does the need for us to downplay slavery, colonization, and Jim Crow continue to be such a strong political force? And whose interests does this down-playing serve in 2023? On this episode, we dissect the notion that the reactionary forces of history have just been "products of their time." We'll explore the ways in which this and related concepts are not only inaccurate, but also convenient instruments of right-wing historical revisionism, and how the need to make people feel good about our civic mythology makes for bad history, and even worse politics. Our guest is historian and museum educator Erin Bartram.

Today we discuss Soil Amelioration and Soil Health and the different mechanical and non mechanical methods to take care of the soil and get the best we can out of it.Soil is a farmers number one priority, if the soil is not healthy then the crop will not be healthy and suffer.Don't forget to reach out to us on Instagram @TheGlassCagePod and let us know what you think of the pod, suggest topics and of course Header Vs Chaser

1.  1815 – Congress of Vienna – Series of international diplomatic meetings to discuss a new European order post the downfall of Napoleon that led to agreements on national boundaries within Europe, Neutrality Pacts, freedom of navigation.  2.  1823 – Monroe Doctrine by James Monroe, then President of US - Any intervention by external powers in the politics of the Americas is a potentially hostile act against the US.  3.  1824 – Calvo Doctrine –  Jurisdiction in international investment disputes lies with the country in which the investment is located. (Carlos Calvo, Argentine Jurist). Used mostly in International Investment Law.  4.  1842 – Treaty of Nanking – Ended the First Opium War between Britain and Qing Dynasty – Its provisions involved cession of Hong Kong to the crown. Was considered an unequal treaty.  5.  1864 – First Geneva Convention for the Amelioration of the Condition of the Wounded in Armies in the Field.  6.  1865 – Establishment of International Telegraph Union to deal with international interconnection, standardization of equipment, tariffs etc.  7.  1871 – Sino-Japanese Friendship and Trade Treaty – Mutual pledge for friendship and cooperation, exchange of ambassadors, trade related provisions.  8.  1899 – First Hague Peace Conference – Establishment of Permanent Court of Arbitration.  9.  1914-1918 – First World War10.  1919 – Treaty of Versailles – Disarmament of Germany, payment of reparations by Germany, territorial concessions etc.  11.  1920 – Paris Peace Conference – Establishment of League of Nations – a worldwide intergovernmental organization to maintain world peace.  12.  1920 - Establishment of Permanent Court of International Justice.  13.  1923 - Establishment of the Hague Academy of International Law  14.  1928 – Kellogg-Briand Pact – International Agreement on peace – was aimed at preventing the second world war.  15.  1939-1945 – Second World War16.  26.06.1945 – Signing of Charter of United Nations  17.  18.04.1946 – Replacement of Permanent Court of International Justice by International Court of Justice.  18.  10.12.1948 – Adoption of Universal Declaration of Human Rights by UN GA.

GRDC, the Irrigated Cropping Council and the NSW Department of Primary Industries have teamed up to explore the influence of soil amelioration and soil amendments on crop yield and profitability in irrigated farming systems. So far there have been mixed results from the project which aims to give growers an understanding of the costs and benefits of deep ripping on sodic soils. Download the transcript for this episode   Contact: Irrigated Cropping Council Damian Jones damian.jones@irrigatedcroppingcouncil.com.au More Information:         Irrigated Cropping Council Research – Optimising Irrigated Grains Project Code: ICF1906-002RTX Learn more about your ad choices. Visit megaphone.fm/adchoices

Julien Nicolas, directeur numérique du groupe SNCF, était l'invité de François Sorel dans Tech & Co, ce mercredi 14 juin. Il s'est penché sur les projets de la SNCF pour améliorer les outils à la gare en utilisant l'IA, sur BFM Business. Retrouvez l'émission du lundi au jeudi et réécoutez la en podcast.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.30.526359v1?rss=1 Authors: Koketsu, S., Matsubara, K., Ueki, Y., Shinohara, Y., Inoue, K., Murakami, S., Ueki, T. Abstract: The pathophysiology of depression remains elusive, and its early diagnostic method has not been established. Accumulated evidence demonstrate that environmental stress affects the hippocampus, functioning in cognition and sociality, and causes various depressive symptoms. In addition, recent findings showed that environmental stress influenced the hippocampal activity correlated with neuroinflammation, and impaired the hippocampal sharp wave ripples (SWRs), pattens of spike sequences, and the theta rhythms, a strong oscillation observed in the hippocampus. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.26.505426v1?rss=1 Authors: Birolini, G., Valenza, M., Ottonelli, I., Talpo, F., Minoli, L., Cappelleri, A., Bombaci, M., Caccia, C., Leoni, V., Passoni, A., Favagrossa, M., Nucera, M. R., Colombo, L., Paltrinieri, S., Bagnati, R., Duskey, J. T., Caraffi, R., Vandelli, M. A., Taroni, F., Salmona, M., Scanziani, E., Biella, G., Ruozi, B., Tosi, G., Cattaneo, E. Abstract: Huntingtons disease (HD) has been linked to reduced synthesis of cholesterol in the brain. Its exogenous delivery to the brain has been shown to be beneficial in the rapidly progressing R6/2 mouse model. Here we used an advanced formulation of brain-permeable nanoparticles (NPs) loaded with cholesterol and called hybrid-g7-NPs-chol, to explore the long-term therapeutical potential of cholesterol administration to the brain of the slow-progressing zQ175DN knock-in HD mouse model. We show that one cycle treatment with hybrid-g7-NPs-chol, administered in the pre-symptomatic or symptomatic phases, is sufficient to completely normalize cognitive defects up to 5 months, as well as to improve other behavioral and neuropathological parameters. Instead, two cycles of hybrid-g7-NPs-chol are needed to achieve long-lasting therapeutic benefits for 12 months without severe inflammatory side-effects. Sustained cholesterol delivery to the brain of zQ175DN mice also reduces mutant Huntingtin aggregates both in striatum and cortex and completely normalizes glutamatergic communication in the striatal medium spiny neurons compared to saline-treated HD mice. These results show that cholesterol delivery via brain-permeable NPs is a safe and versatile therapeutic option for lastingly reversing HD-related behavioral decline and neuropathological signs, highlighting the translational potential of cholesterol-based strategies in HD patients. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

There is an imposter among us. I mean another werewolf that happens to be a professor! Also as the gang returns from Reggie's night of wolfery

There is an imposter among us. I mean another werewolf that happens to be a professor! Also as the gang returns from Reggie's night of wolfery

In our latest podcast, special guest host Pru Cook, from Nine Creeks Consulting, catches up with Michael Moodie to discuss the hot topic of seeding successfully in a an area of the paddock that has had soil amelioration.  Michael discusses the potential pitfalls and highlights important steps to consider when seeding into ameliorated areas including tackling sinking, ensuring even crop establishment and what additional inputs that may be required.  For the latest info on soil amelioration and managing Mallee soils, jump on to the 'Managing Mallee Soils' Facebook discussion page where the topic of soil amelioration has been featured extensively as well as understanding soil constraints, soil testing and managing ground cover. The 'Managing Mallee Soils' group is supported by FRRR with funding through the Australian Government's Future Drought Fund.  Support the show: https://msfp.org.au/about/membership/ See omnystudio.com/listener for privacy information.

In todays episode we look ahead to the 2022 Soil Amelioration/Controlled Traffic Farming Conference on August 3-4 in Perth. Dr David Minkey EO of WANTFA and Bindi Isbister Chair of ACTFA give a preview of what to expect at the conference. To register for the conference and view the program go to www.wantfaconferences.com.au. Take advantage of the steep discount for early bird registration. To find out more about ACTFA and subscribe to Controlled Traffic Farming Australia Magazine go to www.actfa.net to become a member. Follow us on Twitter and Facebook. Industry interested in exhibiting at the conference please e-mail graeme.currie@actfa.net for the prospectus. Thank you.

You may have heard about collagen's ability to help with skin firmness, joint and gut health, and stronger hair, nails, and teeth… but what about collagen for weight loss? Is that among its many purported benefits? Indeed, studies have shown a link between collagen supplementation and weight loss – and the mechanisms for this connection may surprise you.   Most of Us Are Deficient in Collagen Poor diet, stress, lack of sleep… all of these factors play a part in a little-known epidemic of low collagen in adult bodies. woman with upset stomach Approximately 60 to 70 million Americans are affected by some kind of digestive disease, resulting in close to 50 million outpatient visits each year because of GI tract-related issues [1]. At the same time, most people on the planet succumb to the “normal” loss of muscle mass loss as they age: up to 40% [2] less by the time they reach age 40!   Of course, there are many reasons for these shocking statistics. One thing they have in common, however, is that collagen plays a major role in both GI and connective tissue health.   The fact is that a person simply couldn't survive, let alone sit up straight, without collagen. It is a protein, and one of the most abundant found in your body. It's what makes up the interior lining of the gut as well as forms connective tissue. Collagen is a central ingredient for hair formation and its glue-like consistency forms the intricate tissues of the skin at all levels. As we age, we lose it, which is what causes our skin to wrinkle.   The Connection Between Collagen and Weight Loss So, what does all this have to do with collagen for weight loss? Good question! Here are the three main ways that collagen can contribute to a slimmer, more toned figure:   #1 – Collagen helps the gut. Collagen helps with the breakdown of fats and proteins in the gut. The amino acid glycine within collagen also helps maintain the proper pH in the stomach and stimulates gastric juices. Collagen types I and III are literally the raw materials for the connective tissue in the digestive system and there is increasing evidence that collagen supplementation can help repair the intestines and even heal Leaky Gut (aka intestinal permeability).   A 2003 Greek study found that people with Irritable Bowel Syndrome had lower serum collagen levels than those who did not have this connection [3]. A healthy GI tract means more nutrient absorption and less “waste around your waist” as well as less gas and bloat. That's good news for your health in general, as well as your waistline.   #2 – Collagen helps build muscle mass. In fact, collagen IS the “stuff” that makes up connective tissues and muscles in the body! It's a fact that getting the right amount of collagen your body needs can turn “flabby weight” into muscle, as long as you couple your supplementation with a healthy diet and strength training.   A 2016 report [4] in the International Journal of Medical Sciences found that collagen peptide supplementation helped to curb obesity in menopausal women by preventing muscle mass loss. According to the researchers, “collagen supplementation can complete its anti-obesity activity with minor side effects in menopausal women.”   #3 – Collagen speeds metabolism. In the same vein, collagen helps to gently give metabolism a little “kick in the pants” along the way. And here is something that you may not have known: muscle mass has a direct effect on metabolism. This change may be subtle but over time, can be significant.   For example, the University of Maryland [5] researchers analyzed a group of men age 50-65 during an 18-week strength training regime. During the time, the men gained about 2.8 pounds of fat-free mass. At the same time, their metabolic rate increased by a little over 250 calories a day.   And if all this doesn't convince you, check this out. One study found that just 12 weeks of consistent collagen supplementation reduced fat mass in participants by up to 10 pounds [6]!   Build Muscle, Lose Fat the Natural Way Does this mean that you can simply power down a collagen shake every day and never have to work out again? No way! The fact is that nothing replaces a quality, well-balanced diet, and a healthy lifestyle. This includes plenty of movement, stress management,7 self-care, and detoxification.   But collagen supplementation can be an easy and powerful tool to add to your health and fitness toolbox. It's an amazing substance that every cell in your body simply cannot live without. With enough of it, your body can thrive. What's more, getting the best collagen supplement can help you LOOK and FEEL younger, stronger, and possibly even thinner in the process!   RESOURCES: [1] Digestive Diseases Statistics for the United States [2] Strength and muscle mass loss with aging process. Age and strength loss [3] Serum laminin and collagen IV in inflammatory bowel disease. [4] Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate [5] Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men. [6] Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial Looking for the Best Collagen Supplement? What You Need to Know Collagen and Heart Health: What's the Connection? Collagen for Weight Loss? Here's What the Science Says

You may have heard about collagen's ability to help with skin firmness, joint and gut health, and stronger hair, nails, and teeth… but what about collagen for weight loss? Is that among its many purported benefits? Indeed, studies have shown a link between collagen supplementation and weight loss – and the mechanisms for this connection may surprise you.   Most of Us Are Deficient in Collagen Poor diet, stress, lack of sleep… all of these factors play a part in a little-known epidemic of low collagen in adult bodies. woman with upset stomach Approximately 60 to 70 million Americans are affected by some kind of digestive disease, resulting in close to 50 million outpatient visits each year because of GI tract-related issues [1]. At the same time, most people on the planet succumb to the “normal” loss of muscle mass loss as they age: up to 40% [2] less by the time they reach age 40!   Of course, there are many reasons for these shocking statistics. One thing they have in common, however, is that collagen plays a major role in both GI and connective tissue health.   The fact is that a person simply couldn't survive, let alone sit up straight, without collagen. It is a protein, and one of the most abundant found in your body. It's what makes up the interior lining of the gut as well as forms connective tissue. Collagen is a central ingredient for hair formation and its glue-like consistency forms the intricate tissues of the skin at all levels. As we age, we lose it, which is what causes our skin to wrinkle.   The Connection Between Collagen and Weight Loss So, what does all this have to do with collagen for weight loss? Good question! Here are the three main ways that collagen can contribute to a slimmer, more toned figure:   #1 – Collagen helps the gut. Collagen helps with the breakdown of fats and proteins in the gut. The amino acid glycine within collagen also helps maintain the proper pH in the stomach and stimulates gastric juices. Collagen types I and III are literally the raw materials for the connective tissue in the digestive system and there is increasing evidence that collagen supplementation can help repair the intestines and even heal Leaky Gut (aka intestinal permeability).   A 2003 Greek study found that people with Irritable Bowel Syndrome had lower serum collagen levels than those who did not have this connection [3]. A healthy GI tract means more nutrient absorption and less “waste around your waist” as well as less gas and bloat. That's good news for your health in general, as well as your waistline.   #2 – Collagen helps build muscle mass. In fact, collagen IS the “stuff” that makes up connective tissues and muscles in the body! It's a fact that getting the right amount of collagen your body needs can turn “flabby weight” into muscle, as long as you couple your supplementation with a healthy diet and strength training.   A 2016 report [4] in the International Journal of Medical Sciences found that collagen peptide supplementation helped to curb obesity in menopausal women by preventing muscle mass loss. According to the researchers, “collagen supplementation can complete its anti-obesity activity with minor side effects in menopausal women.”   #3 – Collagen speeds metabolism. In the same vein, collagen helps to gently give metabolism a little “kick in the pants” along the way. And here is something that you may not have known: muscle mass has a direct effect on metabolism. This change may be subtle but over time, can be significant.   For example, the University of Maryland [5] researchers analyzed a group of men age 50-65 during an 18-week strength training regime. During the time, the men gained about 2.8 pounds of fat-free mass. At the same time, their metabolic rate increased by a little over 250 calories a day.   And if all this doesn't convince you, check this out. One study found that just 12 weeks of consistent collagen supplementation reduced fat mass in participants by up to 10 pounds [6]!   Build Muscle, Lose Fat the Natural Way Does this mean that you can simply power down a collagen shake every day and never have to work out again? No way! The fact is that nothing replaces a quality, well-balanced diet, and a healthy lifestyle. This includes plenty of movement, stress management,7 self-care, and detoxification.   But collagen supplementation can be an easy and powerful tool to add to your health and fitness toolbox. It's an amazing substance that every cell in your body simply cannot live without. With enough of it, your body can thrive. What's more, getting the best collagen supplement can help you LOOK and FEEL younger, stronger, and possibly even thinner in the process!   RESOURCES: [1] Digestive Diseases Statistics for the United States [2] Strength and muscle mass loss with aging process. Age and strength loss [3] Serum laminin and collagen IV in inflammatory bowel disease. [4] Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate [5] Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men. [6] Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial Looking for the Best Collagen Supplement? What You Need to Know Collagen and Heart Health: What's the Connection? Collagen for Weight Loss? Here's What the Science Says

Olivier Marchal, administrateur de Syntec Conseil et président de Bain & Company France, était l'invité de Christophe Jakubyszyn dans Good Morning Business, ce mercredi 3 novembre. Ils sont revenus sur ses propositions pour accélérer le rebond de l'économie et améliorer la compétitivité, sur BFM Business. Retrouvez l'émission du lundi au vendredi et réécoutez la en podcast.

On this edition of the podcast, we're providing a preview on our WeedSmart Week in Esperance event, which is now only two weeks away!We hear from Beaumont farmers, Phil Longmire, and son Tom. Tom will be presenting at WeedSmart Week, providing a farmer experience on the forum day. Phil, Bindy and Tom Longmire run a family farming business based in Beaumont, 110 km ENE of Esperance in a 425-450mm rainfall zone. Soil amelioration and boundary mapping are just some of the approaches which have really helped them win the war against weeds.We also  catch up with Andrew Messina. Late last year we caught up with Andrew about the trials for Bilberry's spot spraying technology which took place on his farm. He is going to give us an update and a preview of what he's going to share on the Innovation Panel at WeedSmart Week Esperance. NewsWe've got a new article on advances made in weed recognition technologies. In this article we look at how blanket spraying of herbicides in low weed density situations could become a thing of the past in Australia as new weed recognition technologies enable site-specific weed control in-crop. Dr Michael Walsh from University of Sydney provides comment. Read it here. You can also check out our latest webinar recording 'What's next in the North for weed control?' Peter McKenzie, agronomist with Agricultural Consulting & Extension Services, and Angus Dalgliesh, grower and agronomist with Nutrien Ag Solutions, join WeedSmart Northern Extension agronomist Paul McIntosh to discuss some of the weed challenges their clients have been experiencing in the North, and some of the weed management tactics they've been using to deal with these challenges.WeedSmart Week We've got a great program lined up for Esperance WeedSmart Week. This event really is about farmers talking to farmers, as we've heard from our guests today and at the event, we really get to explore that in more detail.The 3-day program consists of a Forum Day at the Esperance Civic Centre with day 2 and 3 consisting of farm visits in the Esperance region to see how forward-thinking growers are implementing the WeedSmart Big 6 tactics to minimise the impact of herbicide resistance on their businesses.You can get your tickets by heading to the WeedSmart website here. 

Your more interesting friends talk about the Olympics, shifting meanings of words and weaponized nostalgia.

You've heard from us before that soil amelioration can be a game changer - it can bury up to 90% of weed seeds!  this edition of the podcast, we're getting a snapshot into how soil amelioration saved the day for Warakirri's Condingup farm manager, Con Murphy, as well as getting an overview of what other Big 6 principles they're using.We'll be visiting Con at Warakirri for WeedSmart Week in Esperance, so this interview gives a great snapshot into what to expect!New contentOur next Regional Update will come out next Monday and we'll be heading to the Northern Region. Make sure you're subscribed on your podcast app of choice so you don't miss it! You can find us by searching "WeedSmart Podcast" on Apple Podcasts, Spotify, Castbox and any other podcast platform. Make sure you check out our latest Ask an Expert. This month Dr Chris Preston answers the question How does ryegrass adapt so readily to farming practices and environmental changes?We've also got a new Case Study for June on Elton and Pam Petersen from Moonie in Queensland.A SwarmFarm robot, ‘Oscar', has added another dimension to their integrated weed management program, which features the majority of the WeedSmart Big 6 tactics.In two summer fallows the Petersens have regained control of glyphosate resistant feathertop Rhodes grass and awnless barnyard grass that was threatening their 2000 ha dryland cropping operation. Be sure to check it out.Webinar Join us to and hear how the WeedSmart's Big 6 strategies are best utilised to combat annual ryegrass in the High Rainfall Zones of South Eastern Australia. Presented by University of Adelaide's Chris Preston, followed by a Q&A with James Manson from Southern Farming Systems. Register here.WeedSmart Week Just a reminder that tickets are now able to be purchased for Esperance WeedSmart Week. It's the first time in 5 years the event will be back in WA. It's happening from the 17th to the 19th of August 2021. WeedSmart Week is designed to engage growers and advisors on WeedSmart's Big 6 messages. You can get your tickets here.    

You may have heard about collagen's ability to help with skin firmness, joint and gut health, and stronger hair, nails, and teeth... but what about collagen for weight loss? Is that among its many purported benefits? Indeed, studies have shown a link between collagen supplementation and weight loss – and the mechanisms for this connection may surprise you. Most of Us Are Deficient in Collagen Poor diet, stress, lack of sleep... all of these factors play a part in a little-known epidemic of low collagen in adult bodies. woman with upset stomach Approximately 60 to 70 million Americans are affected by some kind of digestive disease, resulting in close to 50 million outpatient visits each year because of GI tract-related issues [1]. At the same time, most people on the planet succumb to the “normal” loss of muscle mass loss as they age: up to 40% [2] less by the time they reach age 40! Of course, there are many reasons for these shocking statistics. One thing they have in common, however, is that collagen plays a major role in both GI and connective tissue health. The fact is that a person simply couldn't survive, let alone sit up straight, without collagen. It is a protein, and one of the most abundant found in your body. It's what makes up the interior lining of the gut as well as forms connective tissue. Collagen is a central ingredient for hair formation and its glue-like consistency forms the intricate tissues of the skin at all levels. As we age, we lose it, which is what causes our skin to wrinkle. The Connection Between Collagen and Weight Loss So, what does all this have to do with collagen for weight loss? Good question! Here are the three main ways that collagen can contribute to a slimmer, more toned figure: #1 – Collagen helps the gut. Collagen helps with the breakdown of fats and proteins in the gut. The amino acid glycine within collagen also helps maintain the proper pH in the stomach and stimulates gastric juices. Collagen types I and III are literally the raw materials for the connective tissue in the digestive system and there is increasing evidence that collagen supplementation can help repair the intestines and even heal Leaky Gut (aka intestinal permeability). A 2003 Greek study found that people with Irritable Bowel Syndrome had lower serum collagen levels than those who did not have this connection [3]. A healthy GI tract means more nutrient absorption and less “waste around your waist” as well as less gas and bloat. That's good news for your health in general, as well as your waistline. #2 – Collagen helps build muscle mass. In fact, collagen IS the “stuff” that makes up connective tissues and muscles in the body! It's a fact that getting the right amount of collagen your body needs can turn “flabby weight” into muscle, as long as you couple your supplementation with a healthy diet and strength training. A 2016 report [4] in the International Journal of Medical Sciences found that collagen peptide supplementation helped to curb obesity in menopausal women by preventing muscle mass loss. According to the researchers, “collagen supplementation can complete its anti-obesity activity with minor side effects in menopausal women.” #3 – Collagen speeds metabolism. In the same vein, collagen helps to gently give metabolism a little “kick in the pants” along the way. And here is something that you may not have known: muscle mass has a direct effect on metabolism. This change may be subtle but over time, can be significant. For example, the University of Maryland [5] researchers analyzed a group of men age 50-65 during an 18-week strength training regime. During the time, the men gained about 2.8 pounds of fat-free mass. At the same time, their metabolic rate increased by a little over 250 calories a day. And if all this doesn't convince you, check this out. One study found that just 12 weeks of consistent collagen supplementation reduced fat mass in participants by up to 10 pounds [6]! Build Muscle, Lose Fat the Natural Way Does this mean that you can simply power down a collagen shake every day and never have to work out again? No way! The fact is that nothing replaces a quality, well- balanced diet, and a healthy lifestyle. This includes plenty of movement, stress management,7 self-care, and detoxification. But collagen supplementation can be an easy and powerful tool to add to your health and fitness toolbox. It's an amazing substance that every cell in your body simply cannot live without. With enough of it, your body can thrive. What's more, getting the best collagen supplement can help you LOOK and FEEL younger, stronger, and possibly even thinner in the process! RESOURCES [1] Digestive Diseases Statistics for the United States https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases [2] Strength and muscle mass loss with aging process. Age and strength loss https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940510/ [3] Serum laminin and collagen IV in inflammatory bowel disease. https://www.ncbi.nlm.nih.gov/pubmed/14600124 [4] Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118756/ [5] Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men. https://www.ncbi.nlm.nih.gov/pubmed/8175496 [6] Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/

You may have heard about collagen's ability to help with skin firmness, joint and gut health, and stronger hair, nails, and teeth... but what about collagen for weight loss? Is that among its many purported benefits? Indeed, studies have shown a link between collagen supplementation and weight loss – and the mechanisms for this connection may surprise you. Most of Us Are Deficient in Collagen Poor diet, stress, lack of sleep... all of these factors play a part in a little-known epidemic of low collagen in adult bodies. woman with upset stomach Approximately 60 to 70 million Americans are affected by some kind of digestive disease, resulting in close to 50 million outpatient visits each year because of GI tract-related issues [1]. At the same time, most people on the planet succumb to the “normal” loss of muscle mass loss as they age: up to 40% [2] less by the time they reach age 40! Of course, there are many reasons for these shocking statistics. One thing they have in common, however, is that collagen plays a major role in both GI and connective tissue health. The fact is that a person simply couldn't survive, let alone sit up straight, without collagen. It is a protein, and one of the most abundant found in your body. It's what makes up the interior lining of the gut as well as forms connective tissue. Collagen is a central ingredient for hair formation and its glue-like consistency forms the intricate tissues of the skin at all levels. As we age, we lose it, which is what causes our skin to wrinkle. The Connection Between Collagen and Weight Loss So, what does all this have to do with collagen for weight loss? Good question! Here are the three main ways that collagen can contribute to a slimmer, more toned figure: #1 – Collagen helps the gut. Collagen helps with the breakdown of fats and proteins in the gut. The amino acid glycine within collagen also helps maintain the proper pH in the stomach and stimulates gastric juices. Collagen types I and III are literally the raw materials for the connective tissue in the digestive system and there is increasing evidence that collagen supplementation can help repair the intestines and even heal Leaky Gut (aka intestinal permeability). A 2003 Greek study found that people with Irritable Bowel Syndrome had lower serum collagen levels than those who did not have this connection [3]. A healthy GI tract means more nutrient absorption and less “waste around your waist” as well as less gas and bloat. That's good news for your health in general, as well as your waistline. #2 – Collagen helps build muscle mass. In fact, collagen IS the “stuff” that makes up connective tissues and muscles in the body! It's a fact that getting the right amount of collagen your body needs can turn “flabby weight” into muscle, as long as you couple your supplementation with a healthy diet and strength training. A 2016 report [4] in the International Journal of Medical Sciences found that collagen peptide supplementation helped to curb obesity in menopausal women by preventing muscle mass loss. According to the researchers, “collagen supplementation can complete its anti-obesity activity with minor side effects in menopausal women.” #3 – Collagen speeds metabolism. In the same vein, collagen helps to gently give metabolism a little “kick in the pants” along the way. And here is something that you may not have known: muscle mass has a direct effect on metabolism. This change may be subtle but over time, can be significant. For example, the University of Maryland [5] researchers analyzed a group of men age 50-65 during an 18-week strength training regime. During the time, the men gained about 2.8 pounds of fat-free mass. At the same time, their metabolic rate increased by a little over 250 calories a day. And if all this doesn't convince you, check this out. One study found that just 12 weeks of consistent collagen supplementation reduced fat mass in participants by up to 10 pounds [6]! Build Muscle, Lose Fat the Natural Way Does this mean that you can simply power down a collagen shake every day and never have to work out again? No way! The fact is that nothing replaces a quality, well- balanced diet, and a healthy lifestyle. This includes plenty of movement, stress management,7 self-care, and detoxification. But collagen supplementation can be an easy and powerful tool to add to your health and fitness toolbox. It's an amazing substance that every cell in your body simply cannot live without. With enough of it, your body can thrive. What's more, getting the best collagen supplement can help you LOOK and FEEL younger, stronger, and possibly even thinner in the process! RESOURCES [1] Digestive Diseases Statistics for the United States https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases [2] Strength and muscle mass loss with aging process. Age and strength loss https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940510/ [3] Serum laminin and collagen IV in inflammatory bowel disease. https://www.ncbi.nlm.nih.gov/pubmed/14600124 [4] Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118756/ [5] Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men. https://www.ncbi.nlm.nih.gov/pubmed/8175496 [6] Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/

This week is a Double Feature Circulation on the Run. Please join authors Alexander Benz and Lars Wallentin as they discuss their article "Biomarker-Based Risk Prediction With The ABC-AF Scores in Patients With Atrial Fibrillation Not Receiving Oral Anticoagulation." Then, please join author Timothy McKinsey, editorialist Thomas Gillette and Associate Editor Sergio Lavandero as they discuss the article "HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling" and the editorial "HDAC Inhibition in the Heart: Erasing Hidden Fibrosis." TRANSCRIPT BELOW Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-hosts, I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Greg, I cannot get enough of our double features, and this one's really nice because it's a clinical feature and a preclinical feature, and both are just phenomenally interesting. The first is about the ABC-AF scores. In case you don't recognize it, well, then you just have to listen. Very, very important information on biomarker-based risk prediction in patients with atrial fibrillation, not receiving oral anticoagulation. Then we've got a really interesting paper talking about HDAC inhibition and diastolic dysfunction. Interested? Well, listen up. Dr. Carolyn Lam: First, let's talk about some of the papers in today's issue, shall we? I want to start, Greg. You grab your coffee. I need to talk about this first one, which really provides the first extensive genetic and phenotypic landscape of a very important condition, peripartum cardiomyopathy. This is from Dr. Arany and colleagues from Perlman School of Medicine, University of Pennsylvania. What they did is studied 469 women with peripartum cardiomyopathy, who were identified from several US and international academic centers. They acquired clinical information and DNA samples. Next-generation sequencing was performed on 67 genes and evaluated for the burden of truncating and missense variance. Dr. Carolyn Lam: What they found was that women with peripartum cardiomyopathy bear a significantly high burden of loss of function variants in a number of genes, including familiar ones like TTN, FLNC, DSP, and BAG3. The identity and relative abundance of these variants were remarkably similar to that seen in idiopathic dilated cardiomyopathy, indicating that the genetic predisposition to peripartum cardiomyopathy and dilated cardiomyopathy may be one in the same. Now, while peripartum cardiomyopathy patients with the TTN truncating variants presented with lower ejection fraction. No significant differences in the rates of recovery were seen. Dr. Greg Hundley: Really interesting, Carolyn. Clinically, what are the implications today as we see these patients? Dr. Carolyn Lam: Well, I think the most important one is that genetic counseling and testing should, perhaps, be considered for women with peripartum cardiomyopathy, following the guidelines for dilated cardiomyopathy. What about you, Greg? Dr. Greg Hundley: Very nice, Carolyn. Well, my paper evaluates the role of inflammation and outcomes in patients that sustain out-of-hospital cardiac arrest. It comes to us from Dr. Martin Meyer from Rigshospitalet. Carolyn, out-of-hospital cardiac arrest patients who remain comatose after initial resuscitation are at high risk of morbidity and mortality due to the ensuing post-cardiac arrest syndrome. Now, systemic inflammation constitutes a major component of the post-cardiac arrest syndrome and interleukin 6 levels are associated with this severity. The IL-6 receptor antagonists tocilizumab could potentially dampen inflammation after post-cardiac arrest. The objective of the present trial was to determine the efficacy of tocilizumab to reduce systemic inflammation after out-of-hospital cardiac arrest, A presumed cardiac cause, and thereby potentially mitigate organ injury. Dr. Carolyn Lam: Oh, wow. Interesting, Greg. what did they find? Dr. Greg Hundley: Carolyn, they had 80 comatose out-of-hospital cardiac arrest patients and they were randomized 1:1 in a double-blind, placebo-controlled trial to a single infusion of tocilizumab or placebo, in addition to standard of care, including targeted temperature management. The primary endpoint of the study was reduction of CRP response. This was achieved by tocilizumab, as there was a significant treatment-by-time interaction. Systemic inflammation was reduced by treatment with tocilizumab, as both CRP and leukocyte levels were markedly reduced. Now, myocardial injury was also reduced, documented by reductions in CK-MB and troponin T. However, there were no differences, Carolyn, in survival or neurological outcome. So Carolyn, it looks like for those that survive an out-of-hospital cardiac arrest and do experience neurological recovery, there could be cardiac benefits. Dr. Carolyn Lam: Wow, very interesting. I cannot imagine how difficult it must've been to perform such a trial. Thanks, Greg. Well, the next paper demonstrates a new mechanism underlying diastolic dysfunction, and provides theoretical and experimental evidence to explain, perhaps, the ineffectiveness of conventional nitric oxide enhancement trials for HFpEF. And you know, that's my favorite topic. Dr. Greg Hundley: Wow, Carolyn, really interesting. Can you summarize it for us? Dr. Carolyn Lam: Sure. Well, first of all, this comes from Doctors Eom and Kook from Chonnam National University Biomedical Research Center in Korea. These authors used two animal models of diastolic dysfunction, the salty drinking water, unilateral nephrectomy with aldosterone, or SAUNA, model, and a mild transverse aortic constriction model. They also looked at human heart samples from patients with left ventricular hypertrophy. Dr. Carolyn Lam: Together, in very, very elegant experiments, they showed that neuronal nitric oxide synthase was upregulated in diastolic dysfunction, which increases S-nitrosylation and cardiomyocytes, and its pharmacologic inhibition, as well as genetic ablation, alleviated diastolic dysfunction. Now, specifically, protein S-nitrosylation of histone deacetylase 2, or HDAC2, played a critical role in the development of diastolic dysfunction and nitric oxide reduction and the following protein denitrosylation may provide a novel therapeutic strategy for HFpEF. Dr. Greg Hundley: Very nice, Carolyn. Well, my next paper comes from Dr. William Pu from Boston Children's Hospital and looks at reactive oxygen species-mediated CaM kinase 2 activation, and how that contributes to calcium handling abnormalities and impaired contraction in the Barth syndrome. Carolyn, mutations in tafazzin, a gene required for biogenesis of cardiolipin, the signature phospholipid of the inner mitochondrial membrane, causes Barth syndrome. Carolyn, remember that Barth syndrome occurs primarily in males, is associated with cardiomyopathy, a low white count, and recurrent infections, and also skeletal muscle myopathy and short stature. Cardiomyopathy and the risk of sudden cardiac death are prominent features of the Barth syndrome, but the mechanisms by which impaired cardiolipin biogenesis causes cardiac muscle weakness and these arrhythmias are poorly understood. Dr. Carolyn Lam: Oh, Greg, thanks so much for not quizzing me on that one. I was trying to remember what Barth syndrome is, and thanks for the review. Okay, so what did they find? Dr. Greg Hundley: Right, Carolyn. The investigators identified a molecular pathway that links tafazzin mutation to abnormal calcium handling and decreased cardiomyocyte contractility. This pathway may offer therapeutic opportunities to treat Barth syndrome, and potentially other diseases with elevated mitochondrial reactive oxygen species production. Dr. Carolyn Lam: Thanks, Greg. Nicely summarized. Well, let's go through what else there is in today's issue. There is a Perspective piece by Dr. Singh, entitled The Morbidly Obese Patients with Symptomatic Atrial Fibrillation: Why are we Holding Back on Bariatric Surgery? There's an On My Mind piece by Dr. Wenger on the incremental change versus disruptive transformation: COVID-19 and the cardiovascular community. There's also a research letter by Dr. Phillip on cardiovascular evaluation after COVID-19 in 137 collegiate athletes, and it's the results of an algorithm-guided screening. A very interesting piece. Dr. Greg Hundley: Very nice, Carolyn. Well, Carolyn, in the mailbag, I've got an exchange of letters regarding the article Anti-Inflammatory Actions of Soluble Ninjurin-1 and the Amelioration of Atherosclerosis with Dr. Zheng, Jianmin, and Oh. Then finally, Dr. Rob Califf has an On My Mind piece, entitled Avoiding the Coming Tsunami of Common Chronic Disease: What the Lessons of the COVID-19 Pandemic Can Teach Us. Well, Carolyn, I'm really excited. Another double feature Tuesday. How about we turn our attention and move toward those articles? Dr. Carolyn Lam: Yep. Something for everyone in this one. Let's go. Today's feature discussion will sound somewhat familiar if we're talking about the ABC scores. Now, remember that stands for age, biomarkers, clinical history scores, and they're the scores that we use in patients with atrial fibrillation receiving oral anticoagulation, or at least that's the data we have so far. But, what are the utilities of these ABC scores in patients not receiving oral anticoagulation? Dr. Carolyn Lam: Well, guess what? That's what today's feature paper is all about. I'm so pleased to have with us today, the first author, Dr. Alexander Benz, from Population Health Research Institute, McMaster University in Canada, as well as Dr. Lars Wallentin, he's a senior author from Uppsala University in Sweden. Welcome, gentlemen. Alex, if I could start with you, please. A very interesting question and not so easy to answer, could you please tell us a little bit about the background to your study, what you did, and what you found? Dr. Alexander Benz: Sure. Thanks for the opportunity to speak here. The ABC scores have now been shown to outperform clinical risk scores in the setting of patients with AFib receiving oral anticoagulant therapy. But so far, nobody has ever looked at the performance of these scores in patients who are not treated with oral anticoagulant therapy. So here we validated the ABC stroke, bleeding, and death scores in patients with AFib who were not receiving oral anticoagulant therapy. We chose the ACTIVE A and AVERROES trials, where patients were randomized to receive antiplatelet therapy, so aspirin or aspirin plus clopidogrel, for the validation study. We ended up studying the scores and over 4,300 patients who were receiving either aspirin, which were over 3,195 patients, or aspirin plus clopidogrel in about 1100 patients, in these studies. Dr. Alexander Benz: Now, we found that the ABC stroke score was superior to the CHA2DS2–VASc score, yielding a C-index of 0.7. The ABC bleeding score was also better than the currently recommended HAS-BLED score for the assessment of the risk of bleeding, yielding an overall C-index of 0.73. And finally, the ABC-AF death score yielded a C-index of 0.78, which I think is remarkable. Dr. Alexander Benz: Now, as these scores were derived from patients receiving oral anticoagulant therapy, we're not surprised to see that the ABC stroke score underestimated the risk of stroke in this population. And very similarly, the ABC bleeding score overestimated the risk of bleeding in these patients receiving antiplatelet therapy. So these scores, the ABC stroke and bleeding scores, were recalibrated for our prediction of absolute event rates in the absence of oral anticoagulant therapy. Dr. Carolyn Lam: Thanks, Alex. That was a beautiful summary. Now, Lars, if I could ask you, please, could you really highlight to all of us, what is the key thing about validating these scores in patients with atrial fibrillation, but not receiving oral anticoagulation? Dr. Lars Wallentin: I think what people like to have is an estimate of the risk of stroke and the risk of bleeding. If you start them on oral anticoagulation and that has been difficult, we only knew this based on the risk scores on patients that were on treatment. But if we now are using this score, which are also well-calibrated, we can really estimate the absolute risk of a stroke. Let's say, 3% without oral anticoagulation, then how much is it lowered by oral anticoagulation down to 1%? And we can do this on an individual level, because there is a variability between patients and we can identify the risk for an individual patient without treatment, and the risk on treatment, and that can be balanced then against the risk for bleeding on treatment and without the treatment. And thereby, you can get the precise estimate on the risk-benefit ratio for the individual patients. Dr. Lars Wallentin: This is a precision medicine approach, which we think will provide a better treatment with better outcomes for the patients than we have had before. Also, death can be, of course, involved at the final net benefit, with and without treatment. Therefore, we think this is a great step forward, and this cannot be implemented in the real life because we have used biomarkers that now can be available in the routine laboratories. These are NTproBNP and troponin, which are available in all hospitals, and a new marker, GDF-15, a marker that's related to the bleeding risk and that is currently launched by Roche Diagnostics as a new tool. So I think this is a realistic future to improve treatments. Dr. Carolyn Lam: Dr. Lars, I have to tell you, all us editors fully agreed as well, that this is a great contribution, filling an important gap in the literature so far in a very clinically important question when we face the patient who hasn't started anticoagulation. So really, again, thank you both for this study and for publishing with us. A couple of questions, though. It does require these extra biomarkers that come with some, what can I say, cost of needing to measure them if they're not already measured. Could you give us some idea of how much the scores add to what we're used to, the CHA2DS2–VASc and the HAS-BLED score? I don't know, maybe Alex? Dr. Alexander Benz: Sure. I think one downside of the widely-accepted and also often useD clinical scores is that they rely on Arbitrary categorization and dichotomization of clinical variables, and with biomarkers, we have the great advantage of having a continuous tool to assess the risk of outcomes here. And as Lars mentioned, these are mainly the cardiac biomarkers NTproBNP and cardiac troponin, as well as the GDF-15, or growth differentiation factor 15. We think that biomarkers reflect a powerful tool to also reflect underlying subclinical disease, which is very important, I think, in this stratification, and this is probably where much of the superiority of the biomarker-based tool stems from. Dr. Carolyn Lam: Right, thanks. Back to what Lars had said about more precision, which is exactly what the whole of cardiology is, I think, moving towards as well, but it was very, very clever to look for the studies ACTIVE and AVERROES. Hard to think of the population in which you tested this. But weren't the blood samples in these studies very old? Did you then have to remeasure those biomarkers? Were they reliable? Dr. Lars Wallentin: Yes. These were old samples that were taken at entry into the ACTIVE and AVERROES trial. The investigators in Canada were really very clever to save the sample, but the samples have been saved for a decade or more since then. But fortunately, these assays are very stable over time, so all of them, and therefore the results are reliable. The levels are very similar to the ones we get in the real-life setting for samples as the one we have in ARISTOTLE and RE-LY, where the scores were derived. So this seems to be, I think, also an advantage that this can be used for stored samples, and fresh samples. Dr. Carolyn Lam: Thank you for addressing that so nicely. We're running out of time sadly, but I would love to hear, maybe as final remarks, what you think are the overall clinical implications and perhaps the next steps for important studies that need to be done. Maybe I could ask Alex to start first and then Lars can finish? Dr. Alexander Benz: Well, I think the next steps in the ABC score program will depend on potential integration or a combination of scores, which then may guide physicians in whom to treat or even whom not to treat. Withholding anti-platelet therapy in certain very low-risk patients, that's what comes to mind. I know that Lars and his colleagues are performing a randomized controlled trial in Sweden where they're testing the ABC scores in clinical practice against the usual care with the clinical scores. Maybe, Lars, you want to elaborate on this. Dr. Lars Wallentin: Yeah, I think the final step is, of course, a prospective randomized trial showing which are the real benefits. We are randomizing 6,000 patients to conventional care versus precision medicine-based care using the ABC risk scores. Outcomes are death and stroke and bleeding. I hope that we will find usefulness of this also in a prospective trial, which will be the final piece of evidence, of course. Dr. Carolyn Lam: Wow, Lars, that is amazing. Thank you so much for sharing that with us. First time on Circulation on the Run. Well, audience, I'm sure you enjoyed that. Thank you so much, Lars and Alex. Now, hold on tight, we're going on to our next feature discussion. Dr. Carolyn Lam: Oh, I can't wait to get onto this feature discussion. You see, it's actually going to reveal a potential new way to target diastolic dysfunction. My absolute favorite topic. It's a basic science paper. It is incredible. You're going to hear all about its clinical translational potential and significance, and from none other than the corresponding author, Dr. Timothy McKinsey from University of Colorado School of Medicine, and editorialist of a beautiful accompanying editorial, Dr. Thomas Gillette from UT Southwestern, and Dr. Sergio Lavandero, our Associate Editor from University of Chile, San Diego. Thank you so much for being here. Tim, could I get you started off? Recognizing there are a lot of clinicians listening out there, this is an incredible paper. HDAC, I think for some, it will be the first time you've been hearing such a word. Please, please, could you break it down for us what you did and what you found? Dr. Timothy McKinsey: Sure. Thanks, Carolyn, and thanks for inviting me to do this. It's really a pleasure. HDAC, that stands for a class of enzymes called histone deacetylases, and those are also known as erasers of acetyl marks on chromatin. So they're really famous for the regulation of epigenetics or gene expression. But we found that HDACs do a lot of other things in the heart too, by deacetylating both histone and non-histone proteins, and we're just really interested in the therapeutic potential of inhibiting HDAC enzymes for the treatment of heart failure. And, in so doing, we assess their ability to reverse existing diastolic dysfunction in a mouse model of kidney disease and hypertension. Dr. Carolyn Lam: You know what, Tim, I really liked the way you very carefully said that. A mouse model of diastolic dysfunction with preserved ejection fraction, that I think, previously, a lot of people with just very loosely used the word HFpEF for such a model, but I really, really appreciate how carefully you worded that. Could you tell us a little bit about the model and what you found? Dr. Timothy McKinsey: Sure. Yeah, we've been really careful not to call it a model of HFpEF, because it isn't a model of heart failure. It really is a model of isolated diastolic dysfunction and preserved ejection fraction. It's a model that's been used in the literature in the past, where you perform a uninephrectomy in mice, so remove one kidney, and then implant something called DOCA, which is an aldosterone memetic. And over time, these animals develop systemic hypertension that results in cardiac hypertrophy and diastolic dysfunction. Dr. Timothy McKinsey: We were perplexed because we couldn't see any fibrosis in the model. But when we did a deep dive into fibrosis using more sensitive methods than are traditionally used, we did uncover what we're calling hidden fibrosis. We believe that HDAC inhibitors, our data suggests that HDAC inhibitors, can actually block the formation of hidden fibrosis that leads to diastolic dysfunction. Dr. Carolyn Lam: Very nice. If you could just give us a one-line on how will you find this hidden fibrosis? Dr. Timothy McKinsey: We got stuck on that for years, because we did all the traditional assays to measure cardiac fibrosis, mainly picrosirius red stain, and we didn't see anything. But we were fortunate to team up with some really talented collaborators, including Maggie Lam here at the University of Colorado, who is an expert at using mass spectrometry to study cardiac remodeling, and also Luisa Mestroni and Brisa Peña who use atomic force microscopy to look at tissue stiffness. When we teamed up with those investigators, first with Maggie we found that, sure enough, when we used her sensitive mass spec assay to look at extracellular matrix protein expression in the heart, there was really a profound increase in ECM protein expression in this mouse model, even though the staining for fibrosis was negative. That told us that there was this underlying hidden fibrosis. Dr. Carolyn Lam: Oh, that is really interesting. And so it is that form of fibrosis that was actually reversed, perhaps, by the HDAC inhibition, and that's what you showed. Would that be accurate to say? Dr. Timothy McKinsey: Yeah. So the HDAC inhibitor really had this profound ability to block that ECM remodeling, the hidden fibrosis, to the point where initially we thought it was an artifact. We thought maybe there was a mix-up of samples. It wasn't a mix up. It's just that the compound, this inhibitor of HDAC enzymatic activity, really has this amazing ability to block the formation of hidden fibrosis. Dr. Carolyn Lam: Oh, wow. Wow, Tom, I really, really loved your editorial where you put all of this in context and talked a little bit about the translational and clinical potential. Could you maybe share your thoughts here? I love the title by the way, Erasing Hidden Fibrosis. Dr. Thomas Gillette: Thanks. Thanks for that. Yeah, first of all, Tim, it was a really great piece of work, and it's actually really exciting because when we think of this diastolic dysfunction, and really it's the development of HFpEF, I think, that a lot of people are... It's the single most critical unmet need in cardiovascular medicine, is the treatment for HFpEF. That diastolic dysfunction, it's really that stiffness that Tim was measuring with his atomic force microscopy and those changes in ECM that really seemed to be critical, at least in that model. Dr. Thomas Gillette: And we know from other models as well that these underlying changes in fibrosis and stiffness, perhaps in the ECM, play a really important role, not only in the diastolic dysfunction, but also if you think about in strain as well, because I know in our models of HFpEF and this mouse model of HFpEF, we have the two-hit model published that Gabrielle, a Allie developed with Dr. Hale in Nature. It's that strain that we could measure that really seems to correlate well with the heart failure phenotype. And so it begs the question, has he caught a very early change in the ECM that's really critical to the development of this pathology? And is there a way that we could detect it early on in patients? Is there a way we could measure that in patients and really get a sense of who's progressing and how they're progressing? Dr. Thomas Gillette: Then there's a second point, and I mentioned a little bit in the editorial, I didn't go into it too deeply, and that is, it's really intriguing what this might mean for the development of the disease, because the matrix not only is involved in stiffness, but it's also a reservoir for growth factors, it helps recruit inflammatory cells, and inflammation plays a huge role in HFpEF. And so it begs the question, how many of those changes may proceed a lot of that pathology as well? Dr. Carolyn Lam: Wow, Tom, I really couldn't agree more. I made a big deal earlier about agreeing with Tim, calling this a diastolic dysfunction model rather than HFpEF, but I completely agree with you that the implications are for the development of HFpEF, and it needed the begs, the question of how many patients actually have this hidden fibrosis? And we know that in patients with HFpEF, there is a stage of advanced fibrosis where we feel patients don't respond to treatment as well. So have we caught an early phase that may be clinically applicable? I really loved the way you worded that. But finally, with Sergio, could you put it all together and what the editors thought of this paper? Why you invited Tom to write this editorial? And perhaps what next steps are? Dr. Sergio Lavandero: Okay, Tim, this is really a fascinating work. I have a long road, because in Italy, you develop the most important new concept. The new concept, the hidden fibrosis. The second important, originally, most of the HDAC inhibitors were developed for other diseases, originally for cancer. So now we have more data that, probably, this compound can apply to other diseases like cardiovascular disease. It was difficult to convince at the beginning some reviewers about the concept of hidden fibrosis, because it's not traditional. But finally, we asked to another expert to, "Okay, why don't you explain, please, this new technique?" For the future, Tim, what do you think? How can we evaluate hidden fibrosis in patients? Dr. Timothy McKinsey: Ideally, and you would have a non-invasive approach to assessing hidden fibrosis in patients. Obviously I know myocardial biopsies could be analyzed using the mass spec approach and atomic force microscopy, but not everyone is going to want to get a myocardial biopsy. So ultimately, we would like to correlate data that we obtain with biopsies, with circulating factors to see if there is a non-invasive surrogate circulating factor that correlates with the existence of hidden fibrosis. I think that would be very powerful clinically. Dr. Sergio Lavandero: What do you think the specificity of this research, because maybe it's too broad? What do you think? Dr. Timothy McKinsey: Yeah, that's a great point. There's a negative impression of general HDAC inhibition, because people just can't believe that you could inhibit a large number of HDAC enzymes throughout the body and not kill someone. But you can. And in our models you can use pretty low doses of these HDAC inhibitors and see efficacy. But obviously, the holy grail in this field would be to identify specific HDAC isoforms that regulate specific disease processes. So we have an active area of investigation where we're trying to tease apart the roles of different HDACs in the heart, with the ultimate goal of finding the HDAC or a subset of HDACs that regulate in fibrosis. Then you could selectively inhibit those and perhaps have a safer drug than a general HDAC inhibitor. Dr. Carolyn Lam: Thank you, once again. This is an amazing discussion and really, really an example of just the kind of papers we love publishing at Circulation. So novel and with such translational potential. Thank you, Tim, again, and Tom and Sergio. Thank you, audience, for joining us today. From Greg and I, you've been listening to Circulation on the Run. Don't forget to tune in again next week. Dr. Greg Hundley: This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more, visit ahajournals.org.  

Affection. Limites. Amelioration. Modele

Bindi is an Environmental Scientist with more than 20 years' experience in agricultural research and extension. She grew up on a mixed farm in Kojonup, Western Australia where her Dad passed on his passion for sustainable agriculture. Bindi works two days a week for Department of Primary Industries and Regional Development (DPIRD) WA as a Research Scientist on soil amelioration projects. She also works part-time for Agrarian Management as a Precision Agriculture Consultant. Bindi has developed extensive knowledge of controlled traffic farming and precision agriculture working on state and national projects. This includes writing the NACC Controlled Traffic Farming Technical Manual in 2013 that is a revised version of the original Tramline Farming Manual she wrote in 2003. All this talk of machinery means she has now got tyre kicking down to a fine art! For more information on ACTFA and how to become a member and receive our flagship magazine go to www.actfa.net. Enjoy The Show ACTFA

Welcome back to the WeedSmart Podcast for 2021! Your hosts, Jessica Strauss and Peter Newman will join you again in 2021 each fortnight to look at a timely topic related to weed control. In this episode, we're focusing on soil amelioration. Western Australian Department of Primary Industries and Regional Development Research Scientist, Dr Stephen Davies joins us to explain what’s involved with soil amelioration and the benefits of this approach. We also hear from Daridyn Haywards from Lameroo in the South Australian Mallee. He was involved in a project called: "Spading header rows for grassy weed control, improved crop yields and better soil protection", led by Chris Donohue and has been continuing to adopt the practice of using soil amelioration for both soil improvement and weed control benefits. Daridyn's initial main focus was to build up the organic carbon levels in the soil for improved soil health, water holding capacity & hopefully overcoming the Rhizoctonia issue he faced. The weed seed burial was part of that process as we’ll hear. Peter Newman has been an advocate for soil amelioration for a number of years and has contributed to this article on the subject: https://www.weedsmart.org.au/content/how-does-renovating-non-wetting-sands-help-weed-control/ We also have a great Case Study on Andrew Kenny who uses this approach too: https://www.weedsmart.org.au/content/andrew-kenny-badgingarra-wa/ NEW CONTENT Over the Christmas period our content producer Cindy Benjamin was very busy. There’s a range of new articles and videos available to check out. You can learn all about how to weaponise sorghum crops to take out Feather Top Rhodes and Awnless Barnyard Grass here: https://www.weedsmart.org.au/content/weaponise-sorghum-crops-to-take-out-ftr-and-abg/ And we’ve also got a new article on running down the summer grass seedbank in mungbeans: https://www.weedsmart.org.au/content/run-down-the-summer-grass-seedbank-in-mungbeans/

Welcome to the third episode of the Be Humble Podcast, brought to you by KDTV. Today, we will be talking with Joseph Golish; Joseph is a recovering drug addict who's personal bad experiences have changed him for the better. He will talk about what happened before his addiction started, what happened during, and what's happening right now and what the road to recovery was like. His story is a good one so sit back and enjoy listening to it! If you would ever like to contact Joseph, then follow him on Instagram @imjoseph.golish! --- Support this podcast: https://anchor.fm/kdtvbehumblepodcast/support

During the 19th Century, Britain still held onto many of its colonial territories. But throughout the world, the abolishment of slavery was spreading fast. In the Caribbean and at home, amelioration became a heated topic, used both by abolitionists and slave-owners, to advocate for their interests and decide the future of the sugar-cane industry and the people bound to it.  Today, Professor Kevin Lewis O'Neill is joined by Professor Padraic Scanlan, from the University of Toronto. In this episode, we will discuss how the implementation of amelioration policies did not intend to end racism against newly freed people in the Caribbean. -- This podcast is sponsored by the Centre for Diaspora and Transnational Studies at the University of Toronto. Our Host is Professor Kevin Lewis O'Neill. Between, Across, & Through is produced, edited, and mixed by Ianeke L Romero

Welcome to season two of Amelioration. This episode we talk about the changes we have made to the podcast and where it will go, as well as the company we keep and why. --- Send in a voice message: https://podcasters.spotify.com/pod/show/ameliorationpodcast/message Support this podcast: https://podcasters.spotify.com/pod/show/ameliorationpodcast/support

In this episode, we caught up with Dandaragan grower Duncan Glasfurd to delve into his experience with ameliorating soils, and late-season amelioration in particular. We cover why they choose to wait for rain when ameliorating, the preparation of a paddock prior to amelioration, how management changes following amelioration and all the things to consider before giving it a go that will save you time and money. This conversation was recorded on the 29th of June, 2020.USEFUL LINKS Follow Duncan on Twitter via @DuncanGlasfurdFollow Plozza Plows on Facebook at @PlozzaPlows  and on Twitter via @PlozzaPlowsFeedback Survey via https://airtable.com/shr99hNSKZRIkH9B1RESEARCH LINKSDeep Incorporation Of Lime Into Acidic SubsoilsAmelioration of water repellent sands – long term impacts One-Off Tillage Options For Water Repellent Gravel SoilsClay Spreading On Water Repellent Deep SandLime Incorporation Into Acidic Sandplain Soils In The West MidlandsDeveloping And Testing Innovative, Practical And Reliable Methods For Incorporating Lime Into Acidic Sandplain SubsoilsSupport the show (https://www.wmgroup.org.au/become-member)

Stanford-based Neuroscientist Dr. Marianne Reddan returns to the End of the Road to discuss her recently published study:  "Touch and Social Support Influence Interpersonal Synchrony and Pain," released in April in the Journal Social Cognitive and Affective Neuroscience.   A link to her study can be found here:  https://academic.oup.com/scan/article/doi/10.1093/scan/nsaa048/5821245 More information about Dr. Reddan can be found on her website: http://www.appliedmarianne.com/ P.S.  Yes, the cover photo is Dr. Reddan and her cat.... Her previous interview with the End of the Road can be found here:  https://endoftheroad.libsyn.com/episode-107-dr-marianne-reddan-neuroscienceimaginationextinction-therapy Have a great Fourth of July!  Be safe!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.23.165498v1?rss=1 Authors: Schreglmann, S. R., Wang, D., Peach, R. L., Li, J., Zhang, X., Latorre, A., Rhodes, E., Panella, E., Boyden, E., Barahona, M., Santaniello, S., Bhatia, K. P., Rothwell, J., Grossman, N. Abstract: Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be noninvasively suppressed via electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained after the end of the stimulation and can be phenomenologically predicted. Finally, using feature-based statistical-learning and neurophysiological-modelling we show that the suppression of ET is mechanistically attributed to a disruption of the temporal coherence of the oscillation via perturbation of the tremor generating a cascade of synchronous activity in the olivocerebellar loop. The suppression of aberrant neural oscillation via phase-locked driven disruption of temporal coherence may represent a powerful neuromodulatory strategy to treat brain disorders. Copy rights belong to original authors. Visit the link for more info

1138 English defeat the Scottish at Cowton Moor, Yorkshire. Banners of various saints carried into battle - led to the name Battle of the Standard. The Scottish forces would lose 3/4 of their troops in the battle. 1485 Henry Tudor defeats Richard III at Bosworth Field. The York white rose and the Lancaster red rose meet at the battle, where England's King Richard III is killed by blows to his crown-encircled head. This victory establishes the Tudor dynasty in England and ends the War of the Roses. 1851 U.S. wins first America's Cup. The U.S.-built schooner America bests a fleet of Britain's finest ships in a race around England's Isle of Wight. 1864 International Red Cross founded. The Geneva Convention of 1864 for the Amelioration of the Condition of the Wounded and Sick of Armies in the Field is adopted by 12 nations meeting in Geneva. 1902 Cadillac Autos Founded. Named for the man who founded Detroit in 1801, Antoine Laumet de La Mothe Cadillac, Michigan's newest car company launches. The Cadillac Automobile Company rises from the ashes of the Henry Ford Company, after Ford leaves his company over a squabble with investors. 1942 Brazil declares war on the Axis powers. She is the only South American country to send combat troops into Europe. 1944 Romania captured by the Soviet Union. Soviet forces break through to Jassy, in northeastern Romania, convincing Romania's King Michael to sign an armistice with the Allies and concede control of his country to the USSR. 1945 Conflict in Vietnam begins when a group of Free French parachute into southern Indochina, in response to a successful coup by communist guerilla Ho Chi Minh. 1989 Nolan Ryan registers 5,000th strikeout. He becomes the first pitcher in major league history to register 5,000 career strikeouts. Ryan would go on to rack up a total of 5,714 strikeouts, over 1,500 more than his closest competition.

Inspired by what he saw a neighbouring doing and with GRDC's investment in the Soils Constraints West project & DPIRD support, Corrigin based grain grower Simon Wallwork bought a mouldboard plough from the UK and began a soil amelioration program that is resulting in improved water penetration and better grain yields. Note: related GRDC project codes - DAW00244 Soil Water Repellence and AVP00003-A (RCSN) projects DAW00252, DAW00236 Further information: Simon Wallwork email: swallwork@westnet.com.au https://www.agric.wa.gov.au/climate-land-water/soils/managing-soils

When used strategically, soil amelioration can help grain growers overcome a suite of soil and agronomic constraints, including acidity, water repellence and high weed populations. In this podcast the focus is on crop establishment challenges after soil amelioration, including the use of pre-emergent herbicides. Tom Edwards, a research officer from Western Australia's Dept of Primary Industries and Regional Development has been part of the statewide Soil Constraints West project an investment by GRDC and DPIRD to help improve soil constraints and lift yields and grain grower returns. Further information: Tom Edwards Research officer Department of Primary Industries and Regional Development 3 Melijinup Rd Esperance WA 6450 M - 0427 849 393 P - (08) 9083 1151 E – Tom.Edwards@dpird.wa.gov.au https://www.agric.wa.gov.au/climate-land-water/soils/managing-soils

WA's sand plain soils feature multiple constraints including water repellence, acidity and compaction, all focus points of GRDC's $33-million-dollar investment in the Soil Constraints West Project.Soil constraints result in lost grain production worth more than $4 billion annually, just in WA.A key project outcome is that growers should consider treating multiple constraints over smaller areas, rather than working on one constraint at a time. The 'ranking options for soil amendments' (ROSA) tool provides a cost-effectiveness ranking of soil amendment options to address one or more soil constraints within a farm business. Check out the ROSA decision support tool: https://www.agric.wa.gov.au/climate-land-water/soils/managing-soils GRDC project codes: DAW00244 Soil Water Repellence and AVP00003-A (RCSN) projectsDAW00252, DAW00236 Further information Dr Stephen Davies m: 0408 439 497 ph: 08 9956 8515 email: Stephen.davies@dpird.wa.gov.au

In this episode of Business Second Opinion, Carol Sanford gives a business second opinion on Introducing change for innovation, not amelioration. Find more at www.businesssecondopinion.com Harvard Business Review, Critique, Leadership, change management, change, innovation, disruption, management, leadership development

There is no place of greater safety for civilians and soldiers wounded in today's wars. In 2016 alone there was nearly one attack every day on a hospital in a conflict zone. The most infamous attack came in 2015, when the United States bombed an MSF hospital in Kunduz, Afghanistan. Why? Are we seeing the end of the rules that governed warfare and provision of safe spaces for those caught in the crossfire? The origins of the Red Cross and humanitarian law go back to the middle of the 19th Century, to the battle of Solferino in 1859. The French Army under Napoleon III faced off against the Austrian Army led by Emperor Franz Joseph 1st. The politics behind the battle related to Italian independence but the battle is famous for much more. 300,000 men met on the field of battle near Solferino a small town between Milan and Verona. After nine hours of combat nearly five thousand were dead and more than 22,000 were wounded, many lying where they fell receiving no medical treatment. A Swiss observer of the carnage, Henri Dunant, organized local people to bring some kind of relief to the stricken soldiers. Dunant, a man of private wealth, self-published a book about his experiences, it was the first step in the lobbying that would create the Red Cross in 1863 and the First Geneva Convention or the Amelioration of the Condition of the Wounded in Armies in the Field, the following year. War today is different. Emperors no longer command armies into battle in great open spaces. Conflict is everywhere and involves everyone unlucky enough to be nearby. In WW1 for every 10 soldiers killed 1 civilian died. Today that is reversed. For every soldier killed 10 civilians die.

In this episode of Intercross the Podcast, we are joined by ICRC Deputy Legal Advisor Andrea Harrison to discuss the Geneva Conventions of 1949. The first Geneva Convention was signed in 1864, the year after the founding of the ICRC, and it was for the Amelioration of the Condition of the Wounded in Armies in the Field with 57 States Parties. Most recently, the Geneva Conventions of 1949 were added, in part as a reaction to the tragedies of World War II. How have the content of the Geneva Conventions changed over time? Every State in the world is party to the Geneva Conventions. What does this say about their significance and importance? And 68 years after the 1949 Conventions, with the nature of conflict radically evolving, are they still relevant and can they still stand the test of time? Hosted by Tracey Begley and Niki Clark.

The Geneva Conventions comprise four treaties, and three additional protocols, that establish the standards of international law for humanitarian treatment in war. The singular term Geneva Convention usually denotes the agreements of 1949, negotiated in the aftermath of the Second World War (1939–45), which updated the terms of the two 1929 treaties, and added two new conventions. The Geneva Conventions extensively defined the basic rights of wartime prisoners (civilians and military personnel); established protections for the wounded and sick; and established protections for the civilians in and around a war-zone. The treaties of 1949 were ratified, in whole or with reservations, by 196 countries.[1] Moreover, the Geneva Convention also defines the rights and protections afforded to non-combatants, yet, because the Geneva Conventions are about people in war, the articles do not address warfare proper—the use of weapons of war—which is the subject of the Hague Conventions (First Hague Conference, 1899; Second Hague Conference 1907), and the bio-chemical warfare Geneva Protocol (Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous or other Gasses, and of Bacteriological Methods of Warfare, 1925). In diplomacy, the term convention does not have its common meaning as an assembly of people. Rather, it is used in diplomacy to mean an international agreement, or treaty. The First Geneva Convention "for the Amelioration of the Condition of the Wounded and Sick in Armed Forces in the Field" (first adopted in 1864, revised in 1906, 1929 and finally 1949) The Second Geneva Convention "for the Amelioration of the Condition of Wounded, Sick and Shipwrecked Members of Armed Forces at Sea" (first adopted in 1949, successor of the Hague Convention (X) 1907) The Third Geneva Convention "relative to the Treatment of Prisoners of War" (first adopted in 1929, last revision in 1949) The Fourth Geneva Convention "relative to the Protection of Civilian Persons in Time of War" (first adopted in 1949, based on parts of the Hague Convention (II) of 1899 and Hague Convention (IV) 1907). With two Geneva Conventions revised and adopted, and the second and fourth added, in 1949 the whole set is referred to as the "Geneva Conventions of 1949" or simply the "Geneva Conventions". Usually only the Geneva Conventions of 1949 are referred to as First, Second, Third or Fourth Geneva Convention. The treaties of 1949 were ratified, in whole or with reservations, by 196 countries. Protocols The 1949 conventions have been modified with three amendment protocols: Protocol I (1977) relating to the Protection of Victims of International Armed Conflicts Protocol II (1977) relating to the Protection of Victims of Non-International Armed Conflicts Protocol III (2005) relating to the Adoption of an Additional Distinctive Emblem. Department of Defense. Department of the Army. Office of the Deputy Chief of Staff for Operations. U.S. Army Audiovisual Center. (ca. 1974 - 05/15/1984) ARC Identifier 36015 Local Identifier 111-MF-15-5457 Producer: National Archives and Records Administration Uploaded by: Public.Resource.Org Source Link; https://archive.org/details/gov.archives.arc.36015 Copyright Link https://creativecommons.org/publicdomain/zero/1.0/ Information Link https://en.wikipedia.org/wiki/Geneva_Conventions

Kevin is joined in the Pex Lives recording bunker with friends-of-the-show Gene and Kim to begin answering the question: after the election, what is to be done?   A statement From Gene, Kim and Kevin:   We should not only organize on the basis of reacting to events as they transpire, but we must take the initiative and not allow them to keep us on the back foot. We will defend our existing gains by demanding more, by rejecting complacency. We need to build a movement around those demands in order to create the conditions for the new society. We should not stand for the mere restoration of liberalism, but for supplanting it. We should seek to secure not just the familiar rights, but real liberation founded on material equality. The immediate, short-term struggles must be understood in light of the long struggle. We have to demand what they cannot deliver.    Amelioration is our priority, but we must not substitute reformism for reform. we have no interest in rescuing the Democratic Party from itself. We can use the party for as much as it is useful, but we must remember it is not a neutral tool, and neither is the state. These are organs of the ruling class. Their very structure presupposes rule by the capitalist class. So we must take care.   We don't have all the answers. We can see the broad sweep, but We're just as disoriented as anyone. We may come across as alarmist in the podcast. We don't mean to. We think we should prepare for the worst and consider what we'd do if it came to that, but we can't tell the future, and there are reasons to be optimistic.    We also don't want to get anybody killed or hurt. Assessing risk and figuring out what you can do—that's not for us or anyone to do for you. Just remember that whatever you can contribute will be useful, and stay safe. Your local organizations will probably have better ideas than we do.   Oh, and one last thing: a shoutout to @PissPigGrandDad, who's fighting for the revolution in Rojava. Solidarity with the YPG.   Links:   -Democratic Socialists of America. Join and fight. -Politics is the Solution. Jacobin. -Where Does the Left Go From Here? Jezebel. Particularly check out Roqayah Chamseddine's insights. -A Blueprint for a New Party. Jacobin. -Interview with @PissPigGranddad. Civil Defence Units.

Enjoy this energizing 1 hour set featuring 15 high NRG trance tracks. 1. Tasso - Burning Angel (Intro Edit) 2. Dreamy & Akku - Stakeout (Radio Edit) 3. Ken Plus Ichiro - Neu Tri No (Original Mix) 4. Binary Finary & Dreamy (feat. Natalie Gioia) - Don't Hurt (Original Mix) 5. ReOrder - Sky Harbour (Allen Watts Remix) 6. Nikolauss - Solaris (Original Mix) 7. Simon Patterson & Magnus - Evoke (Extended Mix) 8. Highforcer - Starlight (Shockwaves Remix) 9. Ferrin & Morris - Kiss (Original Mix) 10. Cold Rush (feat. Elles de Graaf) - Daydreamer (Original Mix) 11. UDM - Tornado (Original Mix) 12. Manuel Le Saux - Ryse (Tau-Rine's Energy Remix) 13. Michael Kaelios - Rampage (Original Mix) 14. XGenic - Soothsayer (Original Mix) 15. Stephane Badey - Nightcall (Original Mix)

Debby Bruck studies Allen's Keynotes. Listen to the audio to refresh or begin learning the Keynotes on the Materia medica for each remedy. The reading may be a bit longer than One Minute. ZINCUM METALLICUM Extra Notes: Relations. - Compare: Hell., Tuber., in incipient brain diseasesfrom suppressed eruptions. Aggravation. - Of many symptoms from drinking wine, even asmall quantity (Alum., Con.).Amelioration. - Symptoms: of chest, by expectoration; of bladder,by urinating; of back, by emissions (< by Cobalt.); general, bymenstrual flow. Is followed well by, Ign., but  not by Nux, whichdisagrees.Inimical - Cham., and Nux; should not be used before or after.

welcome to Syria The Truth, our episode title for today is: Syria: Obama Administration Responsible for “Crimes of Aggression” in Violation of Rome Statute and UN Charter. By Dr. Robert P. Abele Global Research, July 03, 2013 On May 23, Secretary of State John Kerry threatened Syrian President Bashar al-Assad with the following statement concerning U.S. military support of Syrian rebels: “In the event that we can’t find that way forward, in the event that the Assad regime is unwilling to negotiate Geneva I in good faith, we will also talk about our continued support and growing support for the opposition in order to permit them to continue to be able to fight for the freedom of their country.” He repeated that threat again yesterday, July 2, using the same appeal to Geneva I. So the obvious question—one completely unaddressed by mainstream media—is: “What does Geneva I say that Kerry is so resolute in appealing to it?” This article aims only to address this question briefly, and to suggest a few points of discussion for an examination of what the U.S. is doing in Syria that might be applicable to Geneva I, which so animates Kerry’s assertions of Assad’s international legal responsibilities. As is the case of all U.S. government pronouncements these days, one must examine the consistency, or lack of it, that stands under or behind U.S. decrees. Those seeking consistency from the Obama administration’s policy toward Syria would be disappointed to learn that Geneva I calls for two specific responsibilities of nations involving themselves in military conflicts within other nations. In each of these two cases, the Obama administration outright ignores these laws while holding Assad accountable to the Convention. Geneva I is entitled “The Amelioration of the Condition of the Wounded and Sick in Armed Forces in the Field.” Among other things, it contains the following two prescriptions for “outsider” nations involving itself in the internal violence of another nation: Art. 11. “Any neutral Power, or any organization invited by the Power concerned or offering itself for these purposes, shall be required to act with a sense of responsibility towards the Party to the conflict on which persons protected by the present Convention depend, and shall be required to furnish sufficient assurances that it is in a position to undertake the appropriate functions and to discharge them impartially.” Art. 50. “Grave breaches to which the preceding Article relates shall be those involving any of the following acts, if committed against persons or property protected by the Convention: willful killing, torture or inhuman treatment, including biological experiments, willfully causing great suffering or serious injury to body or health, and extensive destruction and appropriation of property, not justified by military necessity and carried out unlawfully and wantonly.” Regarding Article 50, we can begin the discussion by noting two things. First, we know that the rebels being supplied by the U.S. have used chemical weapons supplied by the U.S. Although the U.S. has consistently attempted a propaganda campaign to pin this use on Syrian troops, the fact is the opposite: Last month, Syrian rebels in the Al Nusra Front were arrested on the border of Turkey, literally caught red-handed with chemical weapons materials in their possession—i.e. 4-1/2 pounds of sarin nerve gas. In addition, Carla del Ponte, United Nations Commissioner on the board of inquiry regarding Syria, stated publicly that the bulk of the evidence indicates that the rebels being armed by the U.S. are the ones using chemical weapons. Second, one need only examine the barrage of news stories that demonstrate the atrocities of the rebel gangs in Syria being militarily supported by the U.S. Even a cursory examination of the stories demonstrates that these gangs are deliberately attacking civilians and causing other injury and destruction “not justified by military necessity” (Article 50). The standard U.S. line in response to this is that President Assad’s army is doing the same thing. However, this excuse is both morally and legally (to say nothing of logically) insufficient to justify one’s own actions. Regarding Article 11, there likewise are at least two things to be noted to start a discussion about what the U.S. is doing in Syria. First, even given the vague use of the term “responsible” in the Article, one must ask how “responsible” it is to deliberately attempt to overthrow another government that is not threatening to the interfering nation, and which does not have a legitimate internal humanitarian crisis within its borders. The latter is being created by U.S. support of rebel forces, while the former is the fundamental condition for warring against another nation, both in the Rome Statute (see below) and the U.N. Charter. Second, it is important to underscore the most glaringly obvious point regarding the U.S. ignoring international conventions, and that is in the crime of aggression, by definition (in the Rome Statute in 1998, Article 5), the use of armed force by one State against another State without the justification of self-defense or authorization by the U.N. Security Council.  It is based on the dual principles of limiting the power of nations to engage in military aggression, with the sole exception of self-defense, and making that proscription apply equally to all nations. Justice Robert H. Jackson, chief prosecutor in the Nuremberg Trials, made those principles quite clear, and they were used in the U.N. Charter concerning war. For our purposes here, it is important to highlight Article 8, Section I of the Rome Statute, which states that the “crime of aggression” means the planning, preparation, initiation or execution, by a person in a position effectively to exercise control over or to direct the political or military action of a State, of an act of aggression which, by its character, gravity and scale, constitutes a manifest violation of the Charter of the United Nations.” Most critically, note Section 2(g) of the Statute, where the crime of aggression is spelled out most clearly regarding the supply of rebels, such as the U.S. is doing in Syria: “The sending by or on behalf of a State of armed bands, groups, irregulars or mercenaries, which carry out acts of armed force against another State of such gravity as to amount to the acts listed above, or its substantial involvement therein.” So once again, we have a United States government making proclamations and threats holding another government to the letter of the law, while it egregiously violates the most important parts of the law to which they are holding another nation; in this case, Syria. It is not too much for us to demand that the Obama administration act consistently within the rule of law if it intends to capture the moral high ground with regard to its actions in Syria. But, then again, with all the duplicity and direct violations of international law coming out of the administration, capturing the legal or moral high ground seems not to be Obama’s real concern at all. This is much to the detriment and safety of the entire world, since the sole world superpower is demonstrating itself to be simply a rogue state. Dr. Robert P. Abele holds a Ph.D. in Philosophy from Marquette University He is the author of three books: A User’s Guide to the USA PATRIOT Act (2005); The Anatomy of a Deception: A Logical and Ethical Analysis of the Decision to Invade Iraq (2009); Democracy Gone: A Chronicle of the Last Chapters of the Great American Democratic Experiment (2009). Goodnight and goodbye

On episode #13 of the podcast This Week in Microbiology, Stanley, Jo, Michael and Elio discuss how colonic microbial ecology and risk for colitis are regulated by an inflammasome, and amelioration of intestinal inflammation in mice by delivery of a probiotic-derived soluble protein to the colon.