Podcasts about Clinical Cardiology

In this episode, Rosy discusses three important tips for those who are either new to pole dance or returning after a long break. The episode covers the importance of easing into the practice gently, understanding realistic timelines for bodily adaptations, and exercising with friends or a virtual buddy to stay motivated. Link to the warm up video she mentioned: https://www.youtube.com/watch?v=1GAP_7LDgo8 Want to join Rosy for your home pole training? Check out the Slink Through Strength online studio! https://www.slinkthroughstrength.com/ Citations: - Franklin, B. A., Thompson, P. D., Al-Zaiti, S. S., Albert, C. M., Hivert, M. F., Levine, B. D., ... & American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council. (2020). Exercise-related acute cardiovascular events and potential deleterious adaptations following long-term exercise training: placing the risks into perspective–an update: a scientific statement from the American Heart Association. Circulation, 141(13), e705-e736. - de Boer MD, Maganaris CN, Seynnes OR, Rennie MJ, Narici MV. Time course of muscular, neural and tendinous adaptations to 23 day unilateral lower-limb suspension in young men. J Physiol. 2007 Sep 15;583(Pt 3):1079-91. doi: 10.1113/jphysiol.2007.135392. Epub 2007 Jul 26. PMID: 17656438; PMCID: PMC2277190. - Bohm S, Mersmann F, Arampatzis A. Human tendon adaptation in response to mechanical loading: a systematic review and meta-analysis of exercise intervention studies on healthy adults. Sports Med Open. 2015 Dec;1(1):7. doi: 10.1186/s40798-015-0009-9. Epub 2015 Mar 27. PMID: 27747846; PMCID: PMC4532714. - Irwin, B.C., Scorniaenchi, J., Kerr, N.L. et al. Aerobic Exercise Is Promoted when Individual Performance Affects the Group: A Test of the Kohler Motivation Gain Effect. ann. behav. med. 44, 151–159 (2012). https://doi.org/10.1007/s12160-012-9367-4 #poledance #polefitness #homepole

❤️ Bonjour,Bienvenue dans cet épisode consacré au renforcement musculaire 

❤️ Bonjour,Bienvenue dans cet épisode consacré aux animaux. On les aime, ils nous font rire … ils sont de vrais membres de notre famille et nous parlent avec le coeur

Estudios advierten sobre los riesgos del insomnio para la salud cardíaca Para hablar de ello nos acompañó el Dr. Elías Urbáez, Cardiólogo. Miembro de la Sociedad Venezolana de Cardiología y de la Asociación Venezolana de Aterosclerosis. No es ningún secreto que dormir es importante para la salud en términos generales, pero además la falta de sueño podría tener efectos considerables en el corazón, revela un nuevo estudio. Según los investigadores, las personas con insomnio tienen más probabilidades de sufrir un ataque al corazón. El insomnio es el trastorno del sueño, sin duda, más frecuente. Un metaanálisis de investigaciones publicadas anteriormente, divulgado recientemente en la revista Clinical Cardiology, sugiere que la posible asociación entre el insomnio y el riesgo de ataque al corazón es más fuerte en las mujeres. Según expertos, casi todo el mundo experimenta insomnio en algún momento de su vida, quizá en un corto plazo debido a momentos de estrés. Además, definen el insomnio como un trastorno del sueño con tres síntomas principales: - Dificultad para conciliar el sueño - Dificultad para permanecer dormido - Despertarse pronto y no poder volver a dormirse El estudio también halló una relación entre el aumento del riesgo de ataque al corazón y el tiempo que dormían los participantes cada noche. Los que dormían cinco horas o menos presentaban la mayor asociación con el riesgo de infarto y tenían 1,56 veces más probabilidades de sufrir un ataque al corazón que las personas que dormían siete u ocho horas.

This episode with Dr. Pedro Bastos is a broad exploration of the role of inflammation in health and disease.  In popular media, inflammation is regularly referenced only as a process that impairs our health, but as you'll learn today, inflammation also plays an essential and beneficial role in context.  There is good inflammation and bad inflammation, and it is important to understand the difference.Dr. Bastos is a dietitian and researcher affiliated with the European University of Madrid in Spain, and Lund University in Sweden.  At Lund, he studied and collaborated with Staffan Lindeberg, the principal investigator of the famous Kitava Study.  He lectures extensively on health related topics worldwide and has co-authored influential papers such as "The Western Diet and Lifestyle and Diseases of Civilization, and "Chronic Inflammation in the etiology of disease across the lifespan", which was the most cited recent article in the influential journal, Nature Medicine. He has presented at the Ancestral Health Symposium, most recently in 2022 on a recap of the Kitava study.In this conversation, Dr. Bastos discusses the definition and function of inflammation, as well as the distinction between acute and chronic inflammation. He explains the various biomarkers used to detect inflammation and highlights their limitations. The conversation also explores the relationship between inflammation and oxidative stress, as well as the evidence supporting a connection between chronic inflammation and a range of diseases, including metabolic syndrome and autoimmune disorders. Inflammation plays a key role in various health conditions, including cardiovascular disease, Type 2 diabetes, and cancer. Chronic inflammation can both cause and be a consequence of immune processes. The Kitava study, conducted on a traditional population in Papua New Guinea, revealed that their diet, while high in carbohydrates and saturated fat, is relatively unprocessed and has characteristics that low may contribute to their lower levels of inflammation and better health outcomes. Other lifestyle factors, such as physical activity, sun exposure, sleep patterns, stress and lower exposure to pollutants, may also play a role in reducing inflammation-induced disease.  From this, Dr. Bastos discusses how our diets can be tailored to minimize inflammation, including the roles of specific nutrients.  The conversation touches on some debates around inclusion or exclusion of fiber, whole grains, dairy and alcohol. Overall, the discussion emphasizes the complexity of inflammation and the need for personalized approaches to promote optimal health.Resources:  * "Chronic Inflammation in the etiology of disease across the lifespan", Nature Medicine, 24, 1822-1832 (2019) : https://www.nature.com/articles/s41591-019-0675-0* "The western diet and lifestyle and diseases of civilization", Research Reports in Clinical Cardiology 201, 1:2, 15-35 (2011): https://www.dovepress.com/the-western-diet-and-lifestyle-and-diseases-of-civilization-peer-reviewed-fulltext-article-RRCC-MVP * "Revisiting the Kitava study", Ancestral Health Symposium (AH22): Here is a guide to topics discussed in this podcast episode:Time     Topic00:00      Introduction and background01:33      Definition and functions of inflammation04:44      Acute vs. chronic systemic inflammation09:04      Triggers of acute vs. chronic inflammation12:25      Inflammation biomarkers - uses and limitations19:48      Inflammation and oxidative stress26:45      The role of Inflammation in chronic diseases27:17       Inflammation in metabolic syndrome, diabetes and cardiovascular disease29:38       Inflammation in autoimmune disorders31:56       Inflammation in cancers34:04       Inflammation and cellular aging36:58       The Kitava study: Health findings47:54       The Kitava study: Dietary macronutrients, micronutrients and specific foods53:07       Inflammation in Kitavans vs. Swedish controls57:42       The role of lifestyle factors: sleep, physical activity, stress, sun exposure, sleep1:02:30    Mechanisms of stress-Induced Inflammation1:05:32    Pedro's dietary and lifestyle recommendations to control chronic Inflammation1:07:52    The importance of phytochemicals1:13:11    The question of fiber1:16:52    Grains, dairy and alcohol1:25:44    Summary and conclusions Get full access to Ancestral Health Today Substack at ancestralhealth.substack.com/subscribe

It is important to remember our role in recommending simple measures to help our patients and it is worth thinking about the power of take-home information that details the advice you have given.     Check out the Stuff article here - https://www.stuff.co.nz/life-style/wellbeing/300992867/a-virginia-woman-was-feeling-sad-her-doctor-prescribed-her-a-cat   Check out the papers mentioned Qureshi AI, Memon MZ, Vazquez G, Suri MF. Cat ownership and the Risk of Fatal Cardiovascular Diseases. Results from the Second National Health and Nutrition Examination Study Mortality Follow-up Study. J Vasc Interv Neurol. 2009 Jan;2(1):132-5. PMID: 22518240; PMCID: PMC3317329. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317329/  Levine GN, Allen K, Braun LT, Christian HE, Friedmann E, Taubert KA, Thomas SA, Wells DL, Lange RA; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing. Pet ownership and cardiovascular risk: a scientific statement from the American Heart Association. Circulation. 2013 Jun 11;127(23):2353-63. doi: 10.1161/CIR.0b013e31829201e1. Epub 2013 May 9. PMID: 23661721. www.ahajournals.org/doi/full/10.1161/CIR.0b013e31829201e1    www.rnzcuc.org.nz podcast@rnzcuc.org.nz https://www.facebook.com/rnzcuc https://twitter.com/rnzcuc   Music licensed from www.premiumbeat.com Full Grip by Score Squad   This podcast is intended to assist in ongoing medical education and peer discussion for qualified health professionals.  Please ensure you work within your scope of practice at all times.  For personal medical advice always consult your usual doctor 

Dr. Jay Shah is Chief Medical Officer at Aktii, where they are developing technology focused on identifying and monitoring hypertension. Dr. Shah is a practicing Cardiologist who pivoted his career from strictly patent care, to becoming the CMO of a start-up. In this episode he shares  his thoughts on career pivots, how he researched options that were the right fit for him, what it is like to be a CMO in a start-up, what hypertension is and the difficulty of diagnosis, and how wearables can change the way hypertension is managed.    Links from this episode:Jay Shah, MD LinkedIn https://www.linkedin.com/in/jshahmd/Aktiia https://aktiia.com/*****Please click this link to fill out the survey!***** https://form.jotform.com/231946554532056 Support the showConnect with Mastering Medical Device: Website: https://www.masteringmedicaldevice.com LinkedIn: https://www.linkedin.com/company/mastering-medical-device Patrick Kothe LinkedIn: https://www.linkedin.com/in/patrick-kothe Patrick Kothe Twitter: https://twitter.com/patrickkothe Support the show for as little as $3/month: https://www.buzzsprout.com/1286645/support Thanks for listening!

In this episode, we're focusing on NCQA's PCSP—Patient-Centered Specialty Practice Recognition program. As noted on our website, the PCSP Recognition program focuses on coordinating and sharing information among primary care clinicians and specialists. It requires clinicians to organize care around patients—across all clinicians seen by a patient. Patients and their families or other caregivers are included in planning care and considered partners in managing conditions.Specialty practices that earn NCQA's PCSP Recognition communicate more effectively with primary care, integrate services better with primary care and improve the quality of their care. Patients see the difference through reduced costs, better data and records management, improved identification and oversight of chronic conditions, and more face time with a more satisfied medical staff.For this interview, we found one of our greatest advocates of the PCSP Recognition program, an extremely busy and dedicated medical team from Providence Heart Institute in Portland, Oregon. A number of years ago, they saw the need for PCSP, found solutions that worked conclusively and spread the word throughout their company about the effectiveness of the patient-centered specialty practice model of care. Xiaoyan Huang, MD, Chief of Clinical Cardiology, leads clinical operations and care transformation for advanced heart failure, electrophysiology, general cardiology and interventional cardiology subspecialties. Danielle Christensen is Clinical Program Manager at the Providence Heart Institute in Oregon. With experience in both ambulatory and acute care settings, Danielle's expertise spans business development and strategy, change management and development, and the optimized exchange of electronic health records. Dr. Huang and Danielle led a session at NCQA's first Health Innovation Summit in the fall of 2022. And they ran a fascinating and informative training webinar which is still available for download on our education website. The title of their course: “CCE Quarterly: Building with a Blueprint: Taking a Patient-Centered Specialty Practice from Medical Neighborhood to High Performing Network.” The interview is hosted by NCQA's Senior Vice President for Product and Customer Operations, Lori Ferguson. Later on, in our Fast Facts segment, we observe National Minority Mental Health Awareness Month with important stats to share with colleagues and community. Among many of our products and measures addressing behavioral health needs, we mention is NCQA's “Managed Behavioral Health Organization Accreditation” or MBHO, an important accreditation for employers.

Picture this: you're standing in the energy drink aisle of your local supermarket, scanning the cans of vibrant colors and flashy designs. Among the long list of ingredients, you see one name pop up repeatedly - taurine. Ever wondered what this mysterious ingredient is and how it impacts your body? You're not alone. Taurine, a common component in energy drinks, has been the subject of numerous research studies and health discussions. Many claims swirl around this ingredient, from incredible health benefits to potential side effects. But how many of these claims are backed by science? Taurine Health Benefits Taurine, often known for its presence in energy drinks, plays a crucial role in various bodily functions. This amino acid, naturally found in meats, fish, and dairy, provides a myriad of benefits, from supporting heart health to boosting athletic performance. Let's delve deeper into these benefits. Heart Health: Taurine shines particularly bright when it comes to heart health. It aids in regulating blood pressure and lowering cholesterol levels. Notably, taurine helps combat atherosclerosis, a process where plaque builds up in your arteries, leading to a potential heart attack. Research in the Experimental & Clinical Cardiology Journal discovered that taurine supplementation effectively reduces the risk of heart disease in individuals with high cholesterol.Beyranvand, Mohammad R., et al. "Effect of Taurine Supplementation on Exercise Capacity of Patients with Heart Failure." Experimental & Clinical Cardiology, vol. 16, no. 2, 2014, pp. 54–57. Thus, maintaining adequate taurine levels can be a significant step towards a healthier heart. Athletic Performance: Taurine is a beloved supplement among athletes and fitness enthusiasts. It plays a key role in muscle function, helping muscles work harder, longer, and safer. Taurine aids in transporting necessary nutrients to your muscles and reduces muscle damage during intense workouts. Research in the Amino Acids Journal showed that taurine supplementation improved exercise performance and reduced muscle damage in trained middle-distance runners.Balshaw, Thomas G., et al. "The Effect of Acute Taurine Ingestion on 3-Km Running Performance in Trained Middle-Distance Runners." Amino Acids, vol. 44, no. 2, 2013, pp. 555-561. Brain Health: Taurine also contributes significantly to brain health by acting as a neuroprotective agent. It helps regulate water and mineral salt levels in your blood, crucial for brain function. A study in the Journal of Biomedical Science suggested that taurine could potentially protect against neurodegenerative diseases by reducing oxidative stress and inflammation.Menzie, Janet, et al. "Taurine and Central Nervous System Disorders." Journal of Biomedical Science, vol. 21, no. 1, 2014, p. 19. Eye Health: Taurine plays a significant role in maintaining proper vision, even though it might not be the first thing that comes to mind when considering eye health. Taurine is found in high concentrations in the retina, and its deficiency can lead to severe problems, including retinal degeneration. Research published in Molecular Vision showed a direct relationship between taurine deficiency and photoreceptor cell death, leading to impaired vision.Froger, Nicolas, et al. "Taurine: The Comeback of a Neutraceutical in the Prevention of Retinal Degenerations." Molecular Vision, vol. 20, 2012, pp. 733-748. Hearing Protection: Similarly, taurine also appears to play a role in maintaining proper auditory function. A study in Hearing Research found that taurine may help protect against age-related hearing loss in animals.Brozoski, Thomas J., et al. "Taurine Supplementation Prevents Noise-Induced Hearing Loss in the Guinea Pig." Hearing Research, vol. 226, no. 1-2, 2007, pp. 36–45. Though this area is still under investigation, it is possible that taurine could provide similar benefits in humans. Anti-Anxiety: Anxiety is a common affliction in tod...

Curtis Rimmerman, M.D., M.B.A., F.A.C.C. Chairman, International Operations Gus P. Karos Endowed Chair in Clinical Cardiovascular Medicine Cleveland Clinic Cleveland, Ohio USA Curtis Mark Rimmerman, M.D., M.B.A., F.A.C.C. is Chairman, Cleveland Clinic International Operations based in Cleveland, Ohio, U.S.A. From 2015 to 2019, Dr. Rimmerman served in the Middle East as General Manager and Medical Director, Cleveland Clinic successfully conceiving, building, integrating and sustaining a novel healthcare delivery system. Dr. Rimmerman was appointed to the Cleveland Clinic's Professional Staff in 1993 as a staff cardiologist in the Section of Clinical Cardiology. Since 1996, Dr. Rimmerman has been a leader in international healthcare delivery directing multidisciplinary teams both internationally and domestically. In 2001, Dr. Rimmerman was appointed the inaugural holder of the Gus P. Karos Endowed Chair in Clinical Cardiovascular Medicine. Dr. Rimmerman is a fellow of the American College of Cardiology. In addition to his medical operations and international healthcare delivery focus, Dr. Rimmerman's clinical practice encompasses coronary artery and valvular heart disease diagnosis and management. He is passionate about 12-lead electrocardiogram interpretation and education, being the author of multiple books including Interactive Electrocardiography, 3rd Edition, an industry standard. Dr. Rimmerman is a career educator including medical students, residents, fellows and peers. He has directed numerous Cleveland Clinic educational symposia including co founding the Annual Intensive Review of Cardiology Board Review Course. ------------------------------------------------------------------ Professional Focus ∙ International Operations ∙ International Healthcare Delivery ∙ International Business Development ∙ Organizational Effectiveness ∙ Cardiovascular Medicine ∙ Patient Experience and Quality Education ∙ Case Western Reserve University, B.A. - 1983 ∙ Case Western Reserve University, M.D. – 1987 ∙ Case Western Reserve University, M.B.A. - 2001 Training ∙ Internal Medicine Residency, Vanderbilt University - 1990 ∙ Cardiovascular Medicine Fellowship, Krannert Institute of Cardiology, Indiana University - 1993

This is the final episode in our eight-part Perspectives in Clinical Cardiology series. It was originally broadcast as a live webinar on June 22, 2022. It is co-moderated by Dr. David Bewick and Dr. Maral Ouzounian with featured speaker Dr. Gabrielle Horne.

Part seven of the eight-part Perspectives in Clinical Cardiology series. This session took place as a live webinar on April 27, 2022 and features Dr. David Bewick and Dr. Matt Bennett as co-moderators and Dr. Julia Cadrin-Tourigny as the featured speaker. It addresses several common clinical conundrums in preventing SD with an ICD in specific and clinically relevant scenarios.

Have you ever had a broken heart? We have always been told stories about lovers or devastated individuals dying because of their shattered hearts. Maybe their pain and anguish were too much for their hearts to bear. But is this something that could truly happen, or are these just false tales?Takotsubo Cardiomyopathy or also known as the “Broken Heart Syndrome” has been linked to significant emotional stresses and physical stresses that an individual may have experienced and stressful conditions and intense emotions can cause this disease. Though this is a temporary heart condition, unfortunately, data shows that women are more likely prone to this disease.This week we are highlighting this topic as I've invited Dr. Annabelle Santos Volgman, a Professor of Medicine and Senior Attending Physician at Rush Medical College and Rush University Medical Center to share with us this cardiovascular disease, its causes, risk, and what we can do to prevent it.Dr. Anabelle also shares valuable statistics about this disease in men vs women and why we need to be knowledgeable about it to decrease the mortality rate through the help of lifestyle modification and awareness. Don't miss it!Memorable Quotes:Cardiovascular disease is the number one killer of most people in the world, especially in the United States. - Dr. Annabelle Santos VolgmanIncreasing awareness can make a difference. Increasing awareness of the depressants - of all of these risk factors that can be prevented so we could prevent obesity and hypertension, all these cardiovascular diseases, and even cancer with lifestyle modification. - Dr. Julieta GabiolaAbout the Guest:Annabelle Santos Volgman is a Professor of Medicine and Senior Attending Physician at Rush Medical College and Rush University Medical Center. She is the Medical Director of the Rush Heart Center for Women and the recipient of the Madeleine and James McMullan-Carl E. Eybel, MD Chair of Excellence in Clinical Cardiology. She received her undergraduate degree with honors from Barnard College, Columbia University, and her medical degree from Columbia University College of Physicians and Surgeons in New York City.Annabelle is a fellow of the American College of Cardiology and the American Heart Association and completed her residency in Internal Medicine at the University of Chicago Hospitals and Clinics and my Cardiology and Clinical Electrophysiology Fellowship at Northwestern Memorial Hospital in Chicago. She is board-certified in Internal Medicine, Cardiovascular Disease, and Clinical Cardiac Electrophysiology. Follow Annabelle on:FacebookLinkedInAbout the Host:Dr. Jette Gabiola is a Clinical Professor of Medicine at Stanford University and the President & CEO of ABCs for Global Health. Click here for her full profile or read her full interview here. See acast.com/privacy for privacy and opt-out information.

Welcome to part six of the Perspectives in Clinical Cardiology eight-part series, broadcast as a live webinar on March 15, 2022. This session features Dr. David Bewick and Dr. Sarah Ramer, and we are especially delighted to have internationally recognized expert Dr. Allan Klein sharing his knowledge and extensive experience on pericardial disorders.

Topic: Garlic In Nose: Misguided or Dangerous Health Trend?     Dr. Matthew Jay Budoff, MD, FACC, FAHA, professor of medicine at David Geffen School of Medicine at UCLA and the endowed chair of preventive cardiology at Harbor-UCLA Medical Center is one of the foremost authorities on the research behind the healing powers of garlic. He has been the lead researcher on numerous studies showing the benefits of garlic. Budoff is on the editorial boards of several cardiology journals, including Clinical Cardiology, Journal of Invasive Cardiology, JACC: Cardiovascular Imaging, and Cardiovascular Diabetology. Budoff has been named to “America's Top Doctors” , U.S. News & World Report Top Doctor, was awarded the Albert Nelson Marquis Lifetime Achievement Award and also named “The world's most influential scientific researchers” . Contact:  Dr. Matthew Budoff Twitter: @BudoffMd Website: www.calciumscan.com  or find garlic studies at: www.kyolic.com

Meta-analysis affirms benefit for ginseng in type 2 diabetics   Zheijian University (China)   The issue of the journal Medicine published the results of a meta-analysis conducted by researchers at China's Zhejiang University which add evidence to a beneficial effect for ginseng in men and women with impaired glucose tolerance or type 2 diabetes. For their research, Yun-mei Yang and colleagues selected eight trials that included 195 participants treated with ginseng and an equal number of control subjects. The analysis revealed improvements in fasting glucose, post-meal insulin levels and insulin resistance, as well as a reduction in triglycerides, and total and low-density lipoprotein (LDL) cholesterol among ginseng-treated subjects. Our results demonstrate for the first time, an improved lipid profile (triglycerides, total cholesterol, and LDL) associated with ginseng-related therapy in patients with type 2diabetes mellitus or impaired glucose tolerance. Moreover, ginseng-related therapy was more effective in terms of hemoglobin A1c and fasting glucose levels, in drug naïve participants than those taking antidiabetic medications, probably due to the masking of the effect of ginseng by antidiabetic medications."   (NEXT)   Want to Lose Weight? Chew Your Food Longer   Waseda University (Japan)   A recent study published in Scientific Reports links chewing with increased energy expenditure and possible obesity prevention. The results out of Waseda University in Japan showed that tasting and chewing food for 30 seconds boosted heat generation after eating. This practice may help you on your weight loss journey. "Increased diet-induced thermogenesis induced by chewing and taste stimuli may help to prevent overweight and obesity," the authors stated. The study found significant energy changes after meals by testing a time of 30 seconds for tasting and chewing. At a rate of one chew per second, the study matched up with the widely-touted guideline of 32 chews per bite. In addition to helping limit your calorie intake, chewing helps start the digestive process, setting your stomach up for soothing success as your meal makes its way through your system. This recent study—admittedly a small one—shows that the act of tasting and active chewing significantly increased thermogenesis, regardless of the consistency of the food itself. It also found tasting and chewing increased the movement of food through the upper GI tract. Slow eating brings mindfulness into your meals, giving your brain time to realize you're full. The result? You eat less, which is key to any weight loss program.   (NEXT)   Children with higher exposure to air pollution and lower exposure to green space have 62% increased risk of ADHD   Barcelona Institute for Global Health   Children living in areas with higher air pollution due to PM2.5 particles and very low levels of green space might have up to 62% increased risk of developing ADHD. On the contrary, children living in greener and less polluted areas have a 50% lower risk of developing the disorder. These are the conclusions of a paper published in Environment International with data from 37,000 children from Vancouver (Canada). The green space analysis revealed that participants living in areas with a greater percentage of vegetation had a lower risk of ADHD. More specifically, the results show that a 12% increase in vegetation percentage was associated with a 10% reduction in the risk of ADHD. Regarding air pollution, the opposite association was observed with PM2.5: participants with a higher exposure to fine particles had higher risk of ADHD (every 2.1 µg increase in the levels of PM2.5 translated into an 11% increase in the risk of ADHD).   (NEXT)   Melatonin supplementation associated with improved heart failure outcomes   Isfahan University of Medical Sciences (Iran), February 23 2022.    A trial reported  in Clinical Cardiology found improvements in N-terminal pro-B-type natriuretic peptide (NT-Pro BNP, a prohormone released by the heart that, when elevated, may be an indicator of heart failure) among heart failure patients who received supplements that contained melatonin. The trial also uncovered better quality of life and composite clinical outcomes in association with melatonin supplementation.

This is part five of eight in the Perspectives in Clinical Cardiology series, originally broadcast as a live webinar on December 15, 2021. It is co-moderated by Dr. David Bewick and Dr. Marc Ruel with featured speaker Dr. Jean-François Légaré.

Part of four of the eight-part Perspectives in Clinical Cardiology series. This session took place as a live webinar on November 17, 2021 and features Dr. David Bewick, Dr. Sean Connors, and Dr. Jeff Healey. It underscores high value topics by using a case-based format addressing important clinical dilemmas revolving around atrial fibrillation, anticoagulation and stroke prevention.

Welcome to part three of the Perspectives in Clinical Cardiology eight-part series. This session was recorded from the live webinar on September 22, 2021. It features speaker Dr. John Mancini and is co-moderated by Dr. David Bewick and Dr. Grace Chua.

This is part two of the Perspectives in Clinical Cardiology eight-part series. It was originally broadcast as a live webinar on June 23, 2021. This session is moderated by Dr. David Bewick and Dr. David Birnie and presented by Dr. Ciorsti MacIntyre.

One of HVC's echo techs had a few great questions that probably many of us also have so we posted these on this podcast.  We cover sudden cardiac death in athletes, Takasubo's cardiomyopathy, and a few other topics.

There are thousands of publications each year, but the American Heart Association (AHA) publication stands out – it is special – a landmark article. The AHA has made a bold move in highlighting and sticking to the science when it comes to protecting the heart from marijuana. American Heart Association Statement: Medical Marijuana, Recreational Cannabis and Cardiovascular Health. A Scientific Statement. Robert Lee Page II, PharmD, MSPH Robert Page is a Professor in the Departments of Clinical Pharmacy and Physical/Rehabilitative Medicine at the University of Colorado Denver, Schools of Pharmacy and Medicine (Aurora), and the clinical pharmacy specialist for the Division of Cardiology Section of Advanced Heart Failure and Heart Transplantation. He is also the Clinical Lead for the Colorado Evidenced Based Drug Utilization Program. Dr. Page received his bachelor's of science degree in biology and chemistry from Furman University (Greenville, SC); bachelor's of science in pharmacy and Pharm.D. degrees from the Medical University of South Carolina (MUSC; Charleston); Masters of Science in Public Health with an epidemiology focus from the University of Colorado School of Medicine (Denver); and specialty residency in pharmacotherapy with a focus in cardiology from MUSC. He is a board-certified pharmacotherapy specialist with added qualifications in cardiology, a Board Certified Geriatric Pharmacist, and a Fellow of the following organizations: the Heart Failure Society of America, the American College of Clinical Pharmacy, the American Heart Association (Council on Clinical Cardiology), the American Society of Consultant Pharmacists, and the American Society of Health-System Pharmacists. Dr Page has served on numerous AHA, HFSA, and ACC committees and is past chair of the Clinical Pharmacology Subcommittee of the Council on Clinical Cardiology, and has been an external reviewer for several ACCF/AHA cardiovascular management guidelines. Dr. Page has 20 years of clinical expertise in the management of patients with heart failure in both the outpatient and inpatient setting. He has published over 200 peer reviewed manuscripts, abstracts, and book chapters in the management of patients with cardiovascular disease.

On this week's episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH takes a look at prophylactic antibiotics for the reduction of potential infective endocarditis.   Quotes:    “As we've continued to see research unpacking some of the risks associated with utilizing antibiotics before a dental procedure, we've actually found that there are incredible risks associated with overuse of antibiotics in our patient population.”   “In fact, the guidelines note that people who are at risk for infective endocarditis are actually regularly exposed to oral bacteria during activities like brushing or flossing. And so the statement remains.”   “New research from the American Heart Association is encouraging optimal oral health as a key component to reducing the risk of infective endocarditis and may play a more profound role than the concerns of bacterial seeding and subsequent utilization of antibiotics prophylactically before dental procedures.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/    Sources:   Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2007;116(15):1736-54. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. J Am Dent Assoc 2008;139 Suppl:3S-24S. Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.  Circulation 2017; 135: e1159-e1195.  Accessed February 21, 2019. Wilson, W. R., Gewitz, M., Lockhart, P. B., Bolger, A. F., DeSimone, D. C., Kazi, D. S., ... & Baddour, L. M. (2021). Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association. Circulation, CIR-0000000000000969.

On this week's episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH takes a look at prophylactic antibiotics for the reduction of potential infective endocarditis.   Quotes:    “As we've continued to see research unpacking some of the risks associated with utilizing antibiotics before a dental procedure, we've actually found that there are incredible risks associated with overuse of antibiotics in our patient population.”   “In fact, the guidelines note that people who are at risk for infective endocarditis are actually regularly exposed to oral bacteria during activities like brushing or flossing. And so the statement remains.”   “New research from the American Heart Association is encouraging optimal oral health as a key component to reducing the risk of infective endocarditis and may play a more profound role than the concerns of bacterial seeding and subsequent utilization of antibiotics prophylactically before dental procedures.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/    Sources:   Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2007;116(15):1736-54. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. J Am Dent Assoc 2008;139 Suppl:3S-24S. Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.  Circulation 2017; 135: e1159-e1195.  Accessed February 21, 2019. Wilson, W. R., Gewitz, M., Lockhart, P. B., Bolger, A. F., DeSimone, D. C., Kazi, D. S., ... & Baddour, L. M. (2021). Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association. Circulation, CIR-0000000000000969.

Welcome to part one of Perspectives in Clinical Cardiology, an eight-part series that covers challenges faced in community cardiology from all regions in Canada. This session originally aired as a live webinar on May 26, 2021 and features Dr. David Bewick, Dr. Sharon Mulvagh, and Dr. Jacqueline Saw as speakers.

Episode 4 of The Master Clinician Project, featuring Dr. Nora Goldschlager: Cardiologist, Chief of Clinical Cardiology at the Zuckerberg San Francisco General Hospital, UCSF Master Clinician, and Professor of Medicine at the UCSF School of Medicine.

In this episode from the ACEP-EQUAL series, guest Dr. Bruce Lo reviews several common intracerebral hemorrhage scoring systems, the components, and tips on how to use them in real world practice. Guests: Bruce Lo, MD, MBA, FACEP Chief, Department of Emergency Medicine, Sentara Norfolk General Hospital Professor of Emergency Medicine, Eastern Virginia Medical School Host: Jason Woods, MD Audio Editor: Kellen Vu www.acep.org/equal References Hemphill JC 3rd, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke. 2001 Apr;32(4):891-7. doi: 10.1161/01.str.32.4.891. PMID: 11283388. Clarke JL, Johnston SC, Farrant M, Bernstein R, Tong D, Hemphill JC 3rd. External validation of the ICH score. Neurocrit Care. 2004;1(1):53-60. doi: 10.1385/NCC:1:1:53. PMID: 16174898. Gregório T, Pipa S, Cavaleiro P, Atanásio G, Albuquerque I, Chaves PC, Azevedo L. Assessment and Comparison of the Four Most Extensively Validated Prognostic Scales for Intracerebral Hemorrhage: Systematic Review with Meta-analysis. Neurocrit Care. 2019 Apr;30(2):449-466. doi: 10.1007/s12028-018-0633-6. PMID: 30426449. Pinho J, Costa AS, Araújo JM, Amorim JM, Ferreira C. Intracerebral hemorrhage outcome: A comprehensive update. J Neurol Sci. 2019 Mar 15;398:54-66. doi: 10.1016/j.jns.2019.01.013. Epub 2019 Jan 14. PMID: 30682522. Øie LR, Madsbu MA, Solheim O, Jakola AS, Giannadakis C, Vorhaug A, Padayachy L, Jensberg H, Dodick D, Salvesen Ø, Gulati S. Functional outcome and survival following spontaneous intracerebral hemorrhage: A retrospective population-based study. Brain Behav. 2018 Oct;8(10):e01113. doi: 10.1002/brb3.1113. Epub 2018 Sep 21. PMID: 30240164; PMCID: PMC6192392. Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, Fung GL, Goldstein JN, Macdonald RL, Mitchell PH, Scott PA, Selim MH, Woo D; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2015 Jul;46(7):2032-60. doi: 10.1161/STR.0000000000000069. Epub 2015 May 28. PMID: 26022637. Houben R, Schreuder FHBM, Bekelaar KJ, Claessens D, van Oostenbrugge RJ, Staals J. Predicting Prognosis of Intracerebral Hemorrhage (ICH): Performance of ICH Score Is Not Improved by Adding Oral Anticoagulant Use. Front Neurol. 2018 Feb 28;9:100. doi: 10.3389/fneur.2018.00100. PMID: 29541054; PMCID: PMC5836590.

Jerry Estep, MD, Section Head of Heart Failure and Transplantation, discusses a Tall Rounds® on the topic of Cardiogenic Shock, focusing on the team approach that is required to provide optimal care. Featuring a presentation from Venu Menon MD, Section Head of Clinical Cardiology, defining cardiogenic shock and including lessons learned from the SHOCK trial and classifications of shock impact on treatment and outcomes.

Commentary by Drs. Julia Grapsa and Borejda Xhyheri

Plagues have fascinated us since antiquity, but the Antonine Plague stands out because one of the most famous physicians in Western history was present to make detailed observations. In this episode, guest host Liam Conway-Pearson explores what we know -- and what we don't know -- about this plague, which ravaged Rome two millennia ago. Plus a brand new #AdamAnswers about using convalescent plasma to treat the Spanish Flu of 1918!   Sources: Adrian Muraru, “On Galen of Pergamum: The Greek Physician and Philosopher of Late Antiquity in the Roman Empire,” Agathos 9, no.2 (2018): 7-20. H. Clifford Lane and Anthony S. Fauci, “Microbial Bioterrorism,” in Harrison’s Principles of Internal Medicine, 20e, ed. J. Larry Jameson et al. (New York: McGraw Hill, 2018), S2. James Greenberg, “Plagued by Doubt: Reconsidering the Impact of a Mortality Crisis in the 2nd C. A.D.,” Journal of Roman Archaeology 16 (2003): 413-425.  Jennifer Manley, “Measles and Ancient Plagues: A Note on New Scientific Evidence,” Classical World 107, no. 3 (Spring 2014): 393-397.  J. F. Gilliam, “The Plague under Marcus Aurelius,” The American Journal of Philology 82, no. 3 (July 1961): 225-251. John Haldon, Hugh Elton, Sabine R. Huebner, Adam Izdebski, Lee Mordechai, and Timothy P. Newfield, “Plagues, Climate Change, and the End of an Empire. A Response to Kyle Harper’s The Fate of Rome (2): Plagues and a Crisis of Empire,” History Compass 6, no. 12 (November 2018). Joseph B. Fullerton and Mark E. Silverman, “Claudius Galen of Pergamum: Authority of Medieval Medicine,” Clinical Cardiology 32, no. 11 (January 2008): E82-E84. Joseph R. McConnell, Andrew I. Wilson, Andreas Stohl, Monica M. Arienzo, Nathan J. Chellman, Sabine Eckhardt, Elisabeth M. Thompson, A. Mark Pollard, and Jørgen Pender Steffensen, “Lead Pollution Recorded in Greenland Ice Indicates European Emissions Tracked Plagues, Wars, and Imperial Expansion during Antiquity,” PNAS 115, no. 22 (May 2018): 5726-5731. J. Rufus Fears, “The Plague under Marcus Aurelius and the Decline and Fall of the Roman Empire,” Infectious Disease Clinics of North America 18 (2004): 65-77. Kyle Harper, The Fate of Rome (Princeton NJ: Princeton University Press, 2017), 23-118. Mike Duncan, The History of Rome, Podcast Audio, 2007-2013. https://thehistoryofrome.typepad.com/the_history_of_rome/archives.html  R. J. Littman and M. L. Littman, “Galen and the Antonine Plague,” The American Journal of Philology 94, no. 3 (Autumn 1973): 243-255. R. P. Duncan-Jones, “The Impact of the Antonine Plague,” Journal of Roman Archaeology 9 (1996): 108-136. “Smallpox,” CDC, last modified June 7, 2016, https://www.cdc.gov/smallpox/transmission/index.html. Vivian Nutton, “The Chronology of Galen’s Early Career,” The Classical Quarterly 23, no. 1 (May 1973): 158-171. Yuki Furuse, Akira Suzuki, and Hitoshi Oshitani, “Origin of Measles Virus: Divergence from Rinderpest Virus between the 11th and 12th Centuries,” Virology Journal 7, no. 52 (March 2010): 1-4.  Catherine Thėves, Eric Crubėzy, and Philippe Biagini, “History of Smallpox and Its Spread in Human Populations,” Microbiology Spectrum 4, no. 4 (April 2015):  Walter Scheidel, “A Model of Demographic and Economic Change in Roman Egypt after the Antonine Plague,” Journal of Roman Archaeology 15 (2002): 97-114.

Dr. Venu Menon, Section Head of Clinical Cardiology and Director of the Cardiac Intensive Care Unit (CICU) at Cleveland Clinic talks with Dr. Paul Cremer and Dr. Penelope Rampersad about Advances in Cardiac Critical Care. Beginning with a historical look at CCU care, Dr. Menon reflects on the changes in critical care over the years. This is followed by a discussion of what CCU care means today, how training has changed, research and quality outcomes, and the role of palliative care in the CCU.

Dan and Carine chat with cardiomyopathy expert Dr. Ed Kasper with regards to his approach to the new onset heart failure patient. This episode is dedicated to Dr. Kasper's mentor and friend, Dr. Kenneth L. Baughman. Dr. Edward K. Kasper, is a graduate of the Johns Hopkins University with a B.A. in Natural Sciences. He earned his M.D. at the University of Connecticut School of Medicine. His internship and residency in Internal Medicine and assistant chief of service (ACS) of the Thayer service as well as his fellowship in Cardiology, were completed at the Johns Hopkins Hospital, where he then joined the faculty in 1993. He is currently the E. Cowles Andrus Professor of Cardiology and Director of Clinical Cardiology at Johns Hopkins Medicine. Show page: https://www.cardionerds.com/heart-failure-awareness-cardionerds-series/

Dr. Venu Menon, Director of the Cardiovascular Fellowship Program and Section Head, Clinical Cardiology and Chetan Huded MD, Interventional Fellow discuss incidence of stroke up to 30 days after TAVR. Dr. Huded published his findings in JAMA . Drs. Menon and Huded discuss the patient population, pulled from the TVT registry and what the findings mean for clinical practice.

Dr. Venu Menon, Director of the Cardiovascular Fellowship Program and Section Head, Clinical Cardiology discusses with Erika Hutt, MD a first year cardiovascular fellow the use of the WATCHMAN, a left atrial appendage closure device, in patients with prior intracranial hemorrhage. Her study was recently published in Heart Rhythm. Drs. Menon and Hutt talk about the study, the patient population as well as the findings and what this means for this patient population in the future.

Dr. Venu Menon, Director of the Cardiovascular Fellowship Program and Section Head, Clinical Cardiology talks with Eoin Donnellen MD, a third year cardiovascular fellow about the impact of radiation induced aortic stenosis on treatment. Dr. Donnellen first describes a paper looking at Aortic Valve Replacement in patients who had had mediastinal radiation vs. those who did not have radiation . His second study looked at outcomes of TAVR in patients with mediastinal radiation associated aortic stenosis. Drs. Menon and Donnellen discuss the findings of both studies and the clinical implications

Dr. Venu Menon, Director of the Cardiovascular Fellowship Program and Section Head, Clinical Cardiology talks with Eoin Donnellen MD, a third year cardiovascular fellow about his recently published paper that looked at pre-ablation bariatric surgery and its impact on the recurrence of atrial fibrillation following atrial fibrillation ablation.

Jane Ferguson:                Hi, everyone. Welcome to episode 29 of Getting Personal: Omics of the Heart, the podcast from Circulation: Genomic and Precision Medicine. I'm Jane Ferguson from Vanderbilt University Medical Center and an associate editor at Circ: Genomic and Precision Medicine. Let's dive in and see what's new in the June issue.                                            First up, Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians from Florian Wünnemann, Guillaume Lettre and colleagues from the University of Montreal. Polygenic scores have the potential to be used to predict disease risk, but have not been broadly validated in different populations. This team was interested in whether polygenic risk scores that have been found to predict coronary artery disease in European ancestry subjects in the UK Biobank would also predict disease in French Canadians. They calculated two different polygenic risk scores in over 3600 cases and over 7000 controls and tested their ability to predict prevalent, incident and recurrent CAD.                                            Both scores predicted prevalent CAD, but did not perform as well in predicting incident or recurrent disease. This maybe because the majority of subjects were on statant treatment. Overall, the study confirms that polygenic risk scores for CAD developed in European ancestry can be used in other populations of European ancestry. However, further work is needed to develop and validate polygenic risk scores in other ancestries and to explore whether well performing risk scores can be developed to predict incident or recurrent disease.                                            Our next paper comes from Farnaz Shoja-Taheri, Michael Davis and colleagues from Emory University and is entitled Using Statistical Modeling to Understand and Predict Pediatric Stem Cell Function. Stem cell therapy is emerging as a potential therapeutic option for treating pediatric heart failure, which otherwise can only be cured through heart transplantation. The success of stem cell therapy depends on many variables, including the reparative ability of the infused cells. In this paper, the author set out to test whether they could predict the behavior of c-kit+ progenitor cells or human CPCs using RNA seq and computational modeling.                                            They obtained CPCs from 32 patients, including eight neonates whose cells are thought to have the highest reparative capacity, and they performed RNA sequencing. The team had previously developed regression models that could link gene expression data from sequencing to phenotypes in the cells, and they tested these models in the CPC cell lines. They tested seven neonate cell lines in vitro and found that cellular proliferation and the chemotactic potential of condition media matched what was predicted by the RNA seq-based model.                                            They used pathway analysis to identify potential mechanisms regulating CPC performance and identified several genes related to immune response, including interleukins and chemokines. They further confirmed the presence of cytokines at the protein level that were associated with well performing cells showing that at least one of the outcomes could be functionally predicted using an ELISA ASA. This type of approach may prove useful to inform ongoing clinical trials to stem cell therapy in congenital heart disease.                                            The next paper, Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy comes to us from Itziar Frades, Johan Björkegren, Inga Peter and colleagues from the Icahn School of Medicine at Mount Sinai. They were interested in understanding mechanisms whereby antiretroviral therapy for HIV leads to increased risk for coronary artery disease. They analyzed the transcriptional responses to 15 different antiretroviral therapy or ART drugs in human cell lines and cataloged the common transcriptional signatures.                                            They then cross-referenced these against gene networks associated with CAD and CAD related phenotypes. They found that 10 of 15 ART response networks were enriched for differential expression and connectivity in an atherosclerotic arterial wall of regulatory gene network identified as causal for CAD. They used cholesteryl ester loaded foam cells in an in vitro model to validate their findings and found that ART treatment increased cholesteryl ester accumulation in foam cells which was prevented when the key network regulator gene, PQBP1, was silenced.                                            Their study highlights a gene network which is altered in response to ART and which promotes foam cells formation, highlighting a mechanistic link between HIV treatment and CAD. Targeting this network potentially through PQBP1 maybe a way to reduce the risk of CAD in individuals treated with antiretroviral drugs. The next paper comes from Brooke Wolford, Whitney Hornsby, Cristen Willer, Bo Yang and colleagues from the University of Michigan and is entitled Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection. They were interested in whether exome sequencing in individuals with thoracic aortic dissection could identify disease associated variance.                                            They conducted exome sequencing in 240 patients and 258 controls and screened 11 genes for potentially pathogenic variance. They identified 24 variance in six genes across 26 cases with no potentially pathogenic variance identified in the controls. They found that carriers of pathogenic variance had significantly earlier age of onset of dissection, higher rates of root aneurysm and greater incidents of aortic disease in family members, while patients without identified variance had more hypertension and a higher rate of smoking.                                            Their study suggests that genetic testing should be considered in patients with thoracic artery dissection particularly in individuals with early age of onset before age 50 and no hypertension with the possibility of cascade screening to follow to identify at risk family members before onset of dissection and possible death. Our next paper is a research letter from Seyedeh Zekavat, Pradeep Natarajan and colleagues from Harvard Medical School, Investigating the Genetic Link Between Arterial Stiffness and Atrial Fibrillation. They aimed to investigate whether arterial stiffness is causal for atrial fibrillation using Mendelian randomization to probe genetic causality.                                            They calculated the genetic component of the arterial stiffness index or ASI, a noninvasive measure of arterial stiffness, in over 131,000 individuals in the UK Biobank. They then assessed whether the genetic predictors of ASI defined as the top six independent variance were also associated with atrial fibrillation in over 225,000 participants in the UK Biobank and in over 588,000 individuals from a multi-ethnic GWAS. They found that the ASI genetic risk score was significantly associated with incident atrial fibrillation in both the UK Biobank and the multi-ethnic AF GWAS.                                            The association held true even after adjustment for age, sex, smoking status, prevalent heart failure, prevalent hypertension, prevalent CAD, prevalent hypercholesterolemia, prevalent diabetes, heart rate, alcohol intake and exercise frequency in the UK Biobank participants. Because some people have hypothesized that atrial fibrillation may actually precede and cause arterial stiffness, the team did the reverse Mendelian randomization experiment and tested whether genetic predictors of AF were associated with the arterial stiffness index. They found no association suggesting that AF does not cause arterial stiffness.                                            In summary, this paper provides genetic evidence supporting arterial stiffness as a causal contributor to atrial fibrillation and suggests that future randomized controlled studies would be warrantied to assess whether methods to reduce arterial stiffness could be protective against atrial fibrillation. The next research letter comes from Scott Damrauer, Kara Hardie, Reed Pyeritz and colleagues from the University of Pennsylvania and is entitled FBN1 Coding Variants and Nonsyndromic Aortic Disease. In this study, the authors were interested in characterizing the frequency of variance associated with Marfan syndrome in the general population.                                            They analyzed data from the Penn Medicine BioBank looking at 12 variance in the FBN1 gene all of which have been reported to associate with Marfan syndrome. Of almost 11,000 individuals who underwent exome sequencing, they identified 70 individuals who were carriers of one of the 12 preselected FBN1 variance. These individuals ranged in age from age 28 to 87 years and 56% of them were male. They combed through clinical data from the participant's electronic health records, including office notes, diagnostic tests and imaging studies.                                            Two individuals had a clinical diagnosis of Marfan syndrome while 21 individuals had evidence of cardiovascular phenotypes related to Marfan syndrome including mitral valve disease, dilated sinus of valsalva, dilated ascending aorta, descending thoracic or abdominal aneurysms or dissections or had undergone surgical procedures involving the mitral valve or thoracic aorta. Compared to age and sex matched controls without known or suspected pathogenic FBN1 variance, the FBN1 variant carriers were significantly more likely to have Marfan syndrome related cardiovascular disease.                                            Although the majority of individuals carrying FBN1 variance did not have documented cardiovascular disease in this study, the data were somewhat limited, meaning that some affected individuals could have been missed. Thus, while the penetrance of these variance appears to be variable, the severe consequences of these FBN1 variance observed in some individuals suggests that clinical screening for carries of these variance is important. To round up this month's issue, we have a scientific statement led by Ferhaan Ahmad and Elizabeth McNally on Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting Standards.                                            This statement comes from the American Heart Association Council on Genomic and Precision Medicine, the Council on Arteriosclerosis, Thrombosis and Vascular Biology, the Council on Basic Cardiovascular Sciences, the Council on Cardiovascular and Stroke Nursing, the Council on Clinical Cardiology and the Stroke Council. In this statement, the writing group lays out the importance of establishing specialized centers of care for individuals affected by inherited cardiovascular diseases. As cardiovascular genetics as a field continues to grow and as genomic medicine becomes part of practice, it is essential for programs to evolve to include this new knowledge and specialization.                                            There are significant challenges in interpreting genetic test results and in evaluating counseling and managing the care of genetically at risk family members who have inherited pathogenic variance, but not yet shown signs of disease. Establishing specialized programs to combine cardiovascular medicine and genetics expertise is an effective way to allow for the integration of multiple types of clinical and genetic data and to improve diagnosis, prognostication and cascade family testing in affected individuals and their families.                                            Training individuals in genetic cardiology will allow for improved care and management of risk in affected or at risk individuals and potentially pave the way for genotype specific therapy. This important and timely scientific statement outlines current best practices for delivering cardiovascular genetic evaluation and care in both the pediatric and the adult settings with a focus on team member expertise and conditions that most benefit from genetic evaluation.                                            That's all for this month. Thank you as always for listening and come back next month for the next installment of papers in Genomic and Precision Medicine. This podcast was brought to you by Circulation: Genomic and Precision Medicine and the American Heart Association Council on Genomic and Precision Medicine. This program is copyright American Heart Association 2019.  

Hosted by: Dr. Danielle Belardo Instagram: @theveggiemd Twitter: @theveggiemd Facebook: The Veggie MD Produced by: Dr. Kasey Johnson Instagram: @drkaseyjohnson   This weeks episode, is ALL about Cardiology (and plant based nutrition of course)!  Research, research, research! Last weekend was the Annual American College of Cardiology National Meeting, where cardiologists from around the world present new research, guidelines, data and evidence in all areas of cardiovascular disease.  I interviewed two esteemed cardiologists during and after ACC 2019.    If you didn't get to attend ACC this year, get ready for your front row seat in this episode! Dr. Robert Ostfeld will take you through his ACC 2019 nutrition presentation, where he will take us through the evidence, research studies, and peer reviewed literature which support a whole food plant based diet as being the most healthful for cardiovascular disease prevention.  Additionally, he tackles the Mediterranean diet AND keto diet, and explains just why plant based diet takes first place.    The second half of the episode, I had the honor to interview Dr. Kim Eagle, who is the editor of the ACC’s website, ACC.org, and the creator of my favorite cardiology podcast, ACC's Eagles Eye View.  We discuss the exciting trials being released at ACC 2019, how to adequately evaluate research studies, and more.     About Kim Eagle MD:  Dr. Kim Eagle is the Albion Walter Hewlett Professor of Internal Medicine, Professor of Health Management and Policy at the University of Michigan School of Public Health, and Director of the Frankel Cardiovascular Center at the University of Michigan. He attended Oregon State University, graduating in 1976 followed by Tufts University Medical School, graduating in 1979. He completed a residency and chief residency in Internal Medicine at Yale-New Haven Hospital from 1979 to 1983 followed by research and clinical fellowships in cardiology and health services research at Harvard Medical School and The Massachusetts General Hospital (MGH) from 1983 through 1986. From 1986 to 1994, Dr. Eagle served MGH where he was promoted to Associate Director of Clinical Cardiology and Associate Professor of Medicine at Harvard before moving to the University of Michigan.  At the University of Michigan, beginning in 1994, Dr. Eagle developed an outcomes research program focusing on quality, cost-effectiveness, practice guidelines, acute coronary syndromes, treatment of aortic diseases, the fight against childhood obesity (Founder -“Project Healthy Schools”), heart disease in special populations and reuse of pacemakers in third world nations (Founder – “Project My Heart Your Heart”). His outcomes research team has led quality improvement initiatives across the state of Michigan in acute MI, heart failure, and coronary intervention. Dr. Eagle has contributed extramural presentations to more than 110,000 learners in 33 U.S. states and 11 countries. He has published 591 peer-reviewed articles, 69 chapters, and edited 8 books including his latest, The Heart of a Champion, co-written with legendary Michigan football coach, Bo Schembechler.  Dr. Eagle has served the American College of Cardiology on numerous committees and task forces. He is the editor of the ACC’s website, ACC.org. He served its Board of Trustees from 2001-2005. He received ACC’s “Master” designation in 2009, and its national Distinguished Teacher Award in 2012.  He served on the National Heart, Lung and Blood Institute’s External Advisory Committee from 2002-2006, and has been Study Chair of its Genetic Causes of Thoracic Aortic Conditions (GenTAC) since 2006. He has served the local and national American Heart Association and he received the national AHA’s Laennec Society’s Clinician Educator Award in 2013. He is past President of the Association of University Cardiologists and a Board Member of the World Medical Relief. In 2014, the University of Michigan and many of Dr. Eagle’s grateful patients created the Kim A. Eagle Professorship in Cardiovascular Medicine and an endowed research fund bearing his name. About Rob Ostfeld MD Robert Ostfeld, MD, MSc, FACC, a cardiologist, is the Director of Preventive Cardiology, the founder and director of the Cardiac Wellness Program at Montefiore Health System, and an Associate Professor of Medicine at the Albert Einstein College of Medicine. Dr. Ostfeld earned his BA from the University of Pennsylvania, graduating Summa Cum Laude and Phi Beta Kappa; his MD from Yale University School of Medicine; and his Masters of Science in Epidemiology from the Harvard School of Public Health. Dr. Ostfeld completed his medical internship and residency at the Massachusetts General Hospital and his cardiology fellowship and research fellowship in Preventive Medicine at Brigham and Women's Hospital - both teaching hospitals of Harvard Medical School.   His professional interests include cardiovascular disease prevention, medical education and clinical research. He speaks widely regarding nutrition and prevention. He earned the Outstanding Full Time Attending of the Year award at Montefiore for excellence in teaching medical residents; the Program Directors Award for dedicated service on behalf of the Montefiore-Einstein Cardiology Fellowship; and was elected to the Leo M. Davidoff Society at Einstein for outstanding achievement in the teaching of medical students.

Discover challenges and successes CV leaders have experienced with telemedicine (recently named healthcare's greatest opportunity and greatest challenge). Also, learn what financial, clinical and operational specifics should be considered when building a telehealth or virtual care program. Marc C Newel, MD, FACC, FSCCT is Director of MHI® Teleheart Program and Chief of Clinical Cardiology at MHI®, and Jacob Corbell, MBA is Executive Vice President of Business Development at Cardiology Institute of the South. For more information, email HeartTalk@medaxiom.com or visit https://www.medaxiom.comFor more information, email HeartTalk@medaxiom.com or visit https://www.medaxiom.com

Description: In this podcast, Dr. Raskin and Dr. Dubowsky discuss the link between periodontal disease and heart disease, health problems related to your oral health and heart health, heart conditions that can affect your dental visit, and the importance of notifying your dentist of any preexisting conditions (including high blood pressure, diabetes, heart disease or heart defects, etc). About Dr. Brian Raskin: Dr. Brian Raskin comes from 3 generations of honorable dentists in Long Island, New York. He, his father, and grandfather received their D.D.S. at New York University College of Dentistry. He is the founder, owner and dentist of Advanced DDS located in Garden City, New York. His practice was founded in 1984 and has become one of the top dental offices in Long Island, offering full service dentistry with IV sedation, dental implants, and same day dentistry using the latest dental techniques and materials. About Dr. Jay Dubowsky: Dr. Jay Dubowsky attended Cornell University and graduated from the College of Human Ecology. He graduated with honors from SUNY Downstate Medical School. He did his internship and residency at NYU, studied Clinical Cardiology at North Shore/LIJ and studied nuclear cardiology at Cornell University Medical Center. After his post graduate studies, Jay joined the Manhasset Medical Group and admits patients to both St Francis Hospital and Northshore University Hospital. He was recently elected Councilor for the New York State Chapter of the American College of Cardiology. He is the Secretary/Treasurer for the organization. He has twice been nominated to the Board of Directors of the Cornell University/College of Human Ecology Alumni Association. He is currently on the Dean’s Advisory Council.  

Inside Health listener and keep fit enthusiast, David Heathcote, wanted advice on how far he should safely push himself when he's training in the gym. In this special programme about the health benefits of keeping active, Dr Mark Porter helps David to find the answer to his question about the exercise "sweet spot". If you struggle to screw the top off a jar, or use your arms to push yourself out of your chair, that's a sure fire sign, according to Dr Philip Conaghan, consultant rheumatologist and Professor of Musculoskeletal Medicine at the University of Leeds, that your muscles are weak. And the good news is that building muscle strength will protect your joints, not damage them. Dr Conaghan tells Mark that there's a worrying lack of understanding about the impact of muscle weakness on arthritic joints. Over the last decade there's been a growing interest in the relationship between activity and the risk of developing cancer. Studies have demonstrated that exercise appears to have a protective effect against at least four different cancers (breast cancer, colon cancer, endometrial cancer and some upper gastrointestinal cancers) and that being fit helps recovery from cancer too. Dr Denny Levett, a consultant in peri-operative medicine and critical care at University Hospital, Southampton who has a special interest in the relationship between exercise and health, says the reason for the apparent protective effect of fitness is still being researched but the evidence that the effect exists is now widely accepted. Professor of Clinical Cardiology, Sanjay Sharma from St George's University of London outlines the benefits to our hearts of keeping active and Park Run fan and regular Inside Health contributor, Dr Margaret McCartney, admits how running has become something of an obsession and promises that the evidence shows that when it comes to getting fitter, it's never too late to start.

Guest: Rick Stouffer, MD Host: Shira Johnson, MD Dr Rick Stouffer, Chief of Clinical Cardiology at University of North Carolina, Chapel Hill, is interviewed by Dr. Shira Johnson. Dr Stouffer provides a state of the art update on drug eluting cardiac stents.

Guest: Rick Stouffer, MD Host: Shira Johnson, MD Dr. Rick Stouffer, Chief of Clinical Cardiology at University of North Carolina, Chapel Hill and Director of Interventional Cardiology gives his update on risk factors and invasive interventions in 2008.