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The movie starts at 5:06 into this episode. We're watching Seltzer & Friedberg's second awful movie of 2008 (Meet The Spartans came out a few months earlier) and you get to join in the misery! Vanessa Minillo and Kim Kardashian star in a "spoof" of Superbad, Cloverfield, No Country For Old Men, Enchanted, Dr. Phil, Myley Cyrus, and Iron Man. Are THE CHIPMUNKS the best part of this movie, and maybe Seltzer and Friedberg's career? Save us! Great article on the careers of Seltzer & Friedberg: https://grantland.com/features/surely-they-cant-be-serious/ --- Remember to Rate (5 Stars), Review (Great show, blah, blah, blah) and Follow us on Apple Podcasts: https://podcasts.apple.com/us/podcast/b-o-boys-movie-box-office/id1489892648 E-mail us: theboboyspodcast@gmail.com Subscribe on Youtube: https://www.youtube.com/@theboboyspodcast Follow us on TikTok and Instagram: @TheBOBoysPod Subscribe on Substack: https://substack.com/@theboboys Our AWESOME artwork was provided by the talented Ellie Skrzat. Check out her work at https://ellieskrzat.com/ Thanks to WannaBO VP of Interns Christopher for running our social media! ---
Wie kommen Jugendliche und die Kommunalpolitik unkompliziert, digital und direkt in den Austausch? Auf diese Frage hat der 20-jährige Leon Pelikan aus Heuchelheim die Antwort: Mit seiner selbstentwickelten App „Political X Change“, die jetzt in Lich vorgestellt wurde. Außerdem: Die Kaiserstraße ist die zentrale Straße in Friedberg. Doch attraktiv findet die Straße kaum jemand in der Kreisstadt. Jetzt tut sich langsam etwas: Die Stadt hat mitgeteilt, die Straße soll umgestaltet werden, die Vorplanung dafür läuft. Und: Das vergangene Wochenende läuft für Uwe Kiehl aus Beselich im Kreis Limburg-Weilburg besonders gut. Der 71-Jährige Apnoe-Taucher holt bei der Tauch-Weltmeisterschaft in Serbien gleich zwei Bronzemedaillen. Beim Streckentauchen mit Flossen stellt er sogar einen deutschen Rekord auf.
The movie starts at 6:15 into this episode. Kevin Sorbo, Carmen Electra, Sean Maguire and the disgusting sidekick from Borat star in maybe Seltzer and Friedberg's worst movie. The movie stinks, but Pat and Clayton are fantastic as always. Enjoy as we watch this awful parody of The 300 and also Rocky and don't forget Ellen. Great article on the careers of Seltzer & Friedberg: https://grantland.com/features/surely-they-cant-be-serious/ --- Remember to Rate (5 Stars), Review (Great show, blah, blah, blah) and Follow us on Apple Podcasts: https://podcasts.apple.com/us/podcast/b-o-boys-movie-box-office/id1489892648 E-mail us: theboboyspodcast@gmail.com Subscribe on Youtube: https://www.youtube.com/@theboboyspodcast Follow us on TikTok and Instagram: @TheBOBoysPod Subscribe on Substack: https://substack.com/@theboboys Our AWESOME artwork was provided by the talented Ellie Skrzat. Check out her work at https://ellieskrzat.com/ Thanks to WannaBO VP of Interns Christopher for running our social media! ---
The movie starts at 14:25 into this episode. Borat, Nacho Libre, Johnny Depp's Willy Wonka, Harry Potter and Paris Hilton are just some of the famous characters "parodied" in Seltzer and Friedberg's 2007 hit Epic Movie. Join The Boys for this EPIC watchalong! Great article on the careers of Seltzer & Friedberg: https://grantland.com/features/surely-they-cant-be-serious/ --- Remember to Rate (5 Stars), Review (Great show, blah, blah, blah) and Follow us on Apple Podcasts: https://podcasts.apple.com/us/podcast/b-o-boys-movie-box-office/id1489892648 E-mail us: theboboyspodcast@gmail.com Subscribe on Youtube: https://www.youtube.com/@theboboyspodcast Follow us on TikTok and Instagram: @TheBOBoysPod Subscribe on Substack: https://substack.com/@theboboys Our AWESOME artwork was provided by the talented Ellie Skrzat. Check out her work at https://ellieskrzat.com/ Thanks to WannaBO VP of Interns Christopher for running our social media! ---
The film starts at 5:35 into this episode. The Boys watch 2006's DATE MOVIE for our bonus miniseries on "The Films of Aaron Seltzer and Jason Friedberg," and you're invited to watchalong. Alyson Hannigan, Eddie Griffin, Fred Willard, Jennifer Coolidge, and cutie pie Carmen Electra form a star studded cast for the first ever Seltzer & Friedberg spoof movie, and The B.O. Boys are commenting through the whole thing! Huge bonus ep. Great article on the careers of Seltzer & Friedberg: https://grantland.com/features/surely-they-cant-be-serious/ --- Remember to Rate (5 Stars), Review (Great show, blah, blah, blah) and Follow us on Apple Podcasts: https://podcasts.apple.com/us/podcast/b-o-boys-movie-box-office/id1489892648 E-mail us: theboboyspodcast@gmail.com Subscribe on Youtube: https://www.youtube.com/@theboboyspodcast Follow us on TikTok and Instagram: @TheBOBoysPod Subscribe on Substack: https://substack.com/@theboboys Our AWESOME artwork was provided by the talented Ellie Skrzat. Check out her work at https://ellieskrzat.com/ Thanks to WannaBO VP of Interns Christopher for running our social media! ---
To kick off our first ever bonus miniseries on THE FILMS OF AARON SELTZER AND JASON FRIEDBERG, The B.O. Boys look back at the original Scary Movie (2000). This Wayans Brothers comedy blockbuster launched the careers of (co-writers) Seltzer & Friedberg... but how does it hold up? We rewatched and are ready to talk about Deputy Doofy, the introduction to Anna Faris and Regina Hall, the Wayans' spoof legacies, and Pat's original experience seeing Scary Movie in a Manhattan theater. Plus we break down the box office of Scary Movie's July 2000 opening weekend! Great article on the careers of Seltzer & Friedberg: https://grantland.com/features/surely-they-cant-be-serious/ --- Remember to Rate (5 Stars), Review (Great show, blah, blah, blah) and Follow us on Apple Podcasts: https://podcasts.apple.com/us/podcast/b-o-boys-movie-box-office/id1489892648 E-mail us: theboboyspodcast@gmail.com Subscribe on Youtube: https://www.youtube.com/@theboboyspodcast Follow us on TikTok and Instagram: @TheBOBoysPod Subscribe on Substack: https://substack.com/@theboboys Our AWESOME artwork was provided by the talented Ellie Skrzat. Check out her work at https://ellieskrzat.com/ Thanks to WannaBO VP of Interns Christopher for running our social media! ---
Es fährt kein Zug, wieder einmal auf der Lahntalbahn. Die Bahn baut hier bis zum 5. Juni. Das heißt dann Ersatzbus statt Bahn, für alle die auf den verschiedenen Strecken zwischen Gießen, Weilburg, Niedernhausen, Aumenau und Limburg unterwegs sind. Sich durch die Stadt fahren lassen, ganz gemütlich an Orte kommen, auch wenn man nicht mehr gut zu Fuß ist - in Friedberg gibt es seit kurzem ein ehrenamtliches Rikscha-Projekt. Von außen ist es ein unscheinbares Fachwerkhaus in Greifenstein-Allendorf im Lahn-Dill-Kreis - doch im Inneren tummeln sich 1000 Fledermäuse unter dem Dach! Und die kann man sich heute Abend live anschauen.
Seit 2014 ist die zentrale Erstaufnahme für Asylsuchende in Suhl auf dem Friedberg. Allerdings nur noch ein paar Monate. Dann wird die Einrichtung geschlossen. Wie geht es mit der Erstaufnahme in Thüringen weiter?
Modern Wisdom: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- David Friedberg is an entrepreneur, investor, and podcaster. What will the future actually look like? With AI dominating the conversation, cutting through the noise matters more than ever. So what's really coming, and what will it cost us? Expect to learn why the future if going to be epic even if the cost is high, why the future of tech and AI might be overblown, why we should care about the moon, what AI will actually do to jobs despite Anthropic's new report, what the future of longevity will look like, why California has turned into a failed state and if David is concerned about the rise of socialism, what David is most excited about right now and much more… Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get up to 20% off Timeline powered by Mitopure (now at a lower price) at https://timeline.com/modernwisdom Get up to $350 off the Eight Sleep Pod 5 at https://eightsleep.com/modernwisdom Get 160+ biomarkers tested for just $1/day and save an extra $25 at https://functionhealth.com/modernwisdom Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com Timestamps: (0:00) Why the Future Is Going to Be Epic(6:20) Who Will Control AI: Big Tech or Everyone?(12:25) Will Everyone Be Able to Use AI Effectively?(21:38) Should We Build Factories on the Moon?(26:53) How AI is Changing the Field of Fusion(37:18) Could Manufacturing on the Moon Boost Earth's Economy?(41:46) The Fight For Power in Space(44:33) The Science Behind Age Reversal(54:11) How Close Are We to Age Reversal?(56:15) Could Living Longer Unlock Human Potential?(01:00:07) Why Controlling Superintelligence is Critical(01:16:01) Is Embryo Selection the Next AI Arms Race?(01:26:30) How Ohalo is Reinventing Agriculture (01:36:25) What's Driving California's Political Decline?(01:50:14) Is Socialism the Worst Idea Ever?(02:06:18) Why Modern Society Feels So Pessimistic Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices
(0:00) Bestie intros (3:05) OpenAI misses targets, Codex gains on Claude (20:02) AI cybersecurity: a market that's about to explode (31:03) Elon vs Sam Altman lawsuit (41:00) Big tech smashes earnings, Capex explosion (52:44) Vibecoding nightmare: AI deleted someone's codebase (58:33) Retatrutide craze: peptides go mainstream (1:06:34) Friedberg's Supreme Court experience Apply for Summit 2026: https://allin.com/events Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://www.instagram.com/missthingthepod https://www.wsj.com/tech/ai/openai-misses-key-revenue-user-targets-in-high-stakes-sprint-toward-ipo-94a95273 https://polymarket.com/event/ipos-before-2027 https://x.com/aakashgupta/status/2049723185617412550 https://arxiv.org/pdf/1803.03635 https://x.com/AISecurityInst/status/2049868227740565890 https://x.com/ns123abc/status/2049527702076449244 https://www.reuters.com/legal/litigation/openai-trial-pitting-elon-musk-against-sam-altman-kicks-off-2026-04-28 https://x.com/ns123abc/status/2049527702076449244 https://www.google.com/finance/quote/CSCO:NASDAQ https://x.com/chamath/status/2049864100143104420 https://x.com/zerohedge/status/2049895327566561683 https://x.com/lifeof_jer/status/2048103471019434248 https://x.com/levie/status/2049163935182733396 https://www.foxnews.com/media/carville-tells-dems-quietly-prepare-power-grab-dc-puerto-rico-statehood-supreme-court-packing
Music fan Brian Koppen chats with music critic Josh Friedberg as they discuss Rock & Roll Hall of Fame artists:Leonard Cohen's “The Future” vs. Michael Jackson's “Will You Be There”Aretha Franklin's “Ain't No Way” vs. Nine Inch Nails' “March of the Pigs”Jay-Z & Kanye West's “Ni**as in Paris” vs. OutKast's “B.O.B.”They also discuss Nirvana's “Where Did You Sleep Last Night” and Otis Redding.Check out Josh Friedberg at https://linktr.ee/joshfriedberg, https://joshfrmusic.substack.com/, and https://www.instagram.com/joshfrmusic!Intro music is from Jussy's Down Open Roads. Check out Jussy at https://soundcloud.com/user-214048265/sets/jussy-demos-1!Support the show
Ingeborg Gleichauf: Ingeborg Bachmann – Die Widerspenstige. Ein Essay | AvivA Verlag 2026 | Preis: 18 Euro | 144 Seiten Von der hr2-Partnerbuchhandlung „Bindernagel“ in Friedberg
Der Industrie- und Autozulieferer Erich Jaeger mit Sitz in Friedberg hat Insolvenz beantragt. Das Unternehmen stellt Steckverbindungen für Autos und Nutzfahrzeuge her und beschäftigt weltweit rund 1.000 Mitarbeitende, darunter 200 in Deutschland. Trotz der Insolvenz soll es mit dem Unternehmen erst mal normal weitergehen. In Mittelhessen warnt die Polizei vor einer neuen Betrugsmasche auf der Verkaufsplattform Kleinanzeigen. Dabei versuchen die Betrüger an Kontodaten der Verkäufer und damit an deren Geld zu kommen. Der kleine Ort Siegbach im Lahn-Dill-Kreis ist mächtig stolz auf seine Vorzeige-Athletin Deborah Levi. Zusammen mit Laura Nolte hat die 28-Jährige vor wenigen Wochen zum zweiten Mal Olympia-Gold im Zweierbob geholt. Ihr Heimatort benennt nun eine Straße nach der Sportlerin.
David Friedberg is an entrepreneur, investor, and podcaster. What will the future actually look like? With AI dominating the conversation, cutting through the noise matters more than ever. So what's really coming, and what will it cost us? Expect to learn why the future if going to be epic even if the cost is high, why the future of tech and AI might be overblown, why we should care about the moon, what AI will actually do to jobs despite Anthropic's new report, what the future of longevity will look like, why California has turned into a failed state and if David is concerned about the rise of socialism, what David is most excited about right now and much more… Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get up to 20% off Timeline powered by Mitopure (now at a lower price) at https://timeline.com/modernwisdom Get up to $350 off the Eight Sleep Pod 5 at https://eightsleep.com/modernwisdom Get 160+ biomarkers tested for just $1/day and save an extra $25 at https://functionhealth.com/modernwisdom Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices
Adam Friedberg, CEO of Mavrek Development, joins us to discuss the ins and outs of large-scale developments in Chicago. Adam starts by explaining how he started in real estate and hustled early on to learn development and value-add construction. He breaks down pitching development deals to investors and various methods for raising money. Adam talks about projects during COVID and how his team pivoted given the unforeseen circumstances. He gets granular on how to most efficiently cut construction costs without negatively impacting the quality of the final product. In typical SUCI fashion, Adam explains why he is doubling down on Chicago investments and why you should too! If you enjoy today's episode, please leave us a review and share with someone who may also find value in this content! ============= Connect with Mark and Tom: StraightUpChicagoInvestor.com Email the Show: StraightUpChicagoInvestor@gmail.com Properties for Sale on the North Side? We want to buy them. Email: StraightUpChicagoInvestor@gmail.com Have a vacancy? We can place your next tenant and give you back 30-40 hours of your time. Learn more: GCRealtyInc.com/tenant-placement Has Property Mgmt become an opportunity cost for you? Let us lower your risk and give you your time back to grow. Learn more: GCRealtyinc.com ============= Guests: Adam Friedberg, Mavrek Development Link: Adam's LinkedIn Link: SUCI Ep 421 - Alec Greenberg Link: Abundance (Book Recommendation) Link: Crain's Chicago Guest Questions: 01:50 Housing Provider Tip - Simplify property management by setting expectations! 03:16 Intro to our guest, Adam Friedberg! 06:41 How to learn value-add construction in real estate. 10:35 Taking down commercial projects in Oak Park. 23:18 Pitching large development deals to investors! 27:10 Lessons learned from developments in 2020. 30:53 Acquiring The Saint Grand development. 37:20 Getting lean on construction costs. 44:14 Upcoming Mavrek developments! 55:31 Adam's bullish outlook on Chicago! 57:53 What is your competitive advantage? 58:00 One piece of advice for new investors. 58:15 What do you do for fun? 58:53 Good book, podcast, or self development activity that you would recommend? 59:34 Local Network Recommendation? 60:33 How can the listeners learn more about you and provide value to you? ----------------- Production House: Flint Stone Media Copyright of Straight Up Chicago Investor 2026.
Adam Friedberg, CEO of Mavrek Development, joins us to discuss the ins and outs of large-scale developments in Chicago. Adam starts by explaining how he started in real estate and hustled early on to learn development and value-add construction. He breaks down pitching development deals to investors and various methods for raising money. Adam talks about projects during COVID and how his team pivoted given the unforeseen circumstances. He gets granular on how to most efficiently cut construction costs without negatively impacting the quality of the final product. In typical SUCI fashion, Adam explains why he is doubling down on Chicago investments and why you should too! If you enjoy today's episode, please leave us a review and share with someone who may also find value in this content! ============= Connect with Mark and Tom: StraightUpChicagoInvestor.com Email the Show: StraightUpChicagoInvestor@gmail.com Properties for Sale on the North Side? We want to buy them. Email: StraightUpChicagoInvestor@gmail.com Have a vacancy? We can place your next tenant and give you back 30-40 hours of your time. Learn more: GCRealtyInc.com/tenant-placement Has Property Mgmt become an opportunity cost for you? Let us lower your risk and give you your time back to grow. Learn more: GCRealtyinc.com ============= Guests: Adam Friedberg, Mavrek Development Link: Adam's LinkedIn Link: SUCI Ep 421 - Alec Greenberg Link: Abundance (Book Recommendation) Link: Crain's Chicago Guest Questions: 01:50 Housing Provider Tip - Simplify property management by setting expectations! 03:16 Intro to our guest, Adam Friedberg! 06:41 How to learn value-add construction in real estate. 10:35 Taking down commercial projects in Oak Park. 23:18 Pitching large development deals to investors! 27:10 Lessons learned from developments in 2020. 30:53 Acquiring The Saint Grand development. 37:20 Getting lean on construction costs. 44:14 Upcoming Mavrek developments! 55:31 Adam's bullish outlook on Chicago! 57:53 What is your competitive advantage? 58:00 One piece of advice for new investors. 58:15 What do you do for fun? 58:53 Good book, podcast, or self development activity that you would recommend? 59:34 Local Network Recommendation? 60:33 How can the listeners learn more about you and provide value to you? ----------------- Production House: Flint Stone Media Copyright of Straight Up Chicago Investor 2026.
Money isn't just numbers. It's emotion, identity, and the stories we carry without realizing it. In this episode, Dr. Felecia Froe sits down with financial coach and author Carrie Friedberg to unpack what's really behind financial stress, even for high-achieving women who "should" have it figured out. Carrie shares her personal journey from overwhelming debt and shame to becoming a financial coach who helps others build clarity, confidence, and peace with money. This conversation goes beyond budgeting. It explores the emotional weight of money, the difference between financial therapy and coaching, and why so many women avoid looking at their numbers even when they're earning well. If you've ever felt anxious, behind, or unsure about your financial situation, this episode will help you understand why and show you a path forward. 00:00 – Carrie's Money Story and Early Patterns 08:24 – When Debt, Shame, and Avoidance Take Over 15:12 – Financial Therapy vs Financial Coaching 22:56 – Building Awareness and Breaking the Cycle 30:13 – Why High Earners Still Feel Financially Stuck 38:32 – Creating Peace, Support, and a New Relationship With Money
Money isn't just numbers. It's emotion, identity, and the stories we carry without realizing it. In this episode, Dr. Felecia Froe sits down with financial coach and author Carrie Friedberg to unpack what's really behind financial stress, even for high-achieving women who "should" have it figured out. Carrie shares her personal journey from overwhelming debt and shame to becoming a financial coach who helps others build clarity, confidence, and peace with money. This conversation goes beyond budgeting. It explores the emotional weight of money, the difference between financial therapy and coaching, and why so many women avoid looking at their numbers even when they're earning well. If you've ever felt anxious, behind, or unsure about your financial situation, this episode will help you understand why and show you a path forward. 00:00 – Carrie's Money Story and Early Patterns 08:24 – When Debt, Shame, and Avoidance Take Over 15:12 – Financial Therapy vs Financial Coaching 22:56 – Building Awareness and Breaking the Cycle 30:13 – Why High Earners Still Feel Financially Stuck 38:32 – Creating Peace, Support, and a New Relationship With Money
Betriebsversammlung bei der Eisengießerei Fritz Winter in Stadtallendorf. Gestern hat das Traditionsunternehmen die Belegschaft über die angespannte Wirtschaftslage und die Sparpläne informiert: Die Beschäftigten sollen auf Weihnachts- und Urlaubsgeldzahlungen verzichten. Gleichzeitig sollen die Gehälter teilweise um bis zu 12% reduziert werden, die Arbeitszeit soll dagegen noch steigen. Es fährt kein Zug, seit heute früh zwischen Friedberg und Nidda. Der Grund: Die Strecke wird grunderneuert. Vor allem neue Weichen und viele, viele Kabel. Damit das neue elektronische Stellwerk in Reichelsheim gesteuert werden kann. Dafür ist die Strecke jetzt in Osterferien gesperrt und dann nochmal im Herbst. Rund 20 Prozent mehr Knöllchen als zuvor. Die gabs im vergangenen Jahr für Verkehrssünder in Gießen. Die Stadt hat seit dem vergangenen Jahr mehr Personal in der Stadtpolizei und der Verkehrsüberwachung - und das führt dazu, dass auch mehr im Stadtverkehr kontrolliert werden kann.
(0:00) Bestie intros!: Friedberg for Governor of California? (2:25) Anthropic's generational run (15:45) OpenAI: getting focused or panic mode? (36:56) AI valuation impacts, moats, and disruption (43:58) Liquidity speaker announcements, the 100x AI moment (50:35) Two landmark social media verdicts against Meta (1:12:46) Sacks and Friedberg join PCAST! Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://polymarket.com/event/which-company-has-the-best-ai-model-end-of-march-751 https://www.wsj.com/tech/ai/openai-chatgpt-side-projects-16b3a825 https://www.reuters.com/business/openai-sweetens-private-equity-pitch-amid-enterprise-turf-war-with-anthropic-2026-03-23 https://www.levernews.com/the-pentagons-ai-gatekeeper-holds-stock-in-anthropics-rival https://x.com/LauraLoomer/status/2037111057701818519 https://x.com/chamath/status/2033385903520129161 https://x.com/TheIcahnist/status/2036902492080837015 https://www.google.com/finance/quote/GOOG:NASDAQ https://www.google.com/finance/quote/LVMUY:OTCMKTS https://x.com/cryptopunk7213/status/2023572182090109380 https://www.google.com/finance/quote/RACE:NYSE?comparison=OTCMKTS https://x.com/Vjay031/status/1985631799448662441 https://www.latimes.com/california/story/2026-03-25/social-media-lawsuit-trial-meta-google-verdict
Malte Lauterbach ist Kriegsberichterstatter. Er war mehrfach in der Ukraine, fuhr bis an die Frontlinie und berichtet von der aktuellen Lage. Malte nimmt uns mit in die Schutzbunker von Kyiv, beschreibt den Alltag der Ukrainer:innen, analysiert die europäische Sicherheitspolitik und beschreibt einen möglichen Weg zum Frieden. Ein wichtiges Gespräch über die Realität des Krieges, die deutsche Unterstützung und die Zukunft Europas. Das Interview wurde live in Friedberg vor Publikum aufgezeichnet.Themen der FolgeAlltag im Luftschutzbunker und Normalisierung des KriegesHumanitäre Lage in den Grenzregionen zur FrontZivile Infrastruktur: Strom, Wärme und GesundheitsversorgungProfil der ukrainischen Soldaten: Vom Zivilisten zum KämpferDeutsche Unterstützung auf dem PrüfstandPerspektiven für Waffenstillstand und FriedensverhandlungenNotwendigkeit einer europäischen Armee und gemeinsame VerteidigungDebatte zur Wiedereinführung der Wehrpflicht in DeutschlandNützliche Links:Foto von Malte im Hintergrund (Mastodon) | (Instagram)Essay von Malte LauterbachBilaterale Unterstützungsleistungen der Bundesregierung für die UkraineUN-Dokumente zur UkraineAdvocating for a European ArmyRoadmap towards a common defence for EuropeÜber VoltVolt ist die erste pan-europäische Partei, aktiv in über 30 Ländern. Volt setzt sich für mehr Teilhabe, Klimaschutz, digitale Innovation und soziale Gerechtigkeit ein. Sie verbindet progressive Politik mit wissenschaftlich fundierten Lösungen und setzt auf transnationale Zusammenarbeit. Europäisch denken, lokal handeln. Mehr dazu unter voltdeutschland.org
CAPPING OFF OUR TWILIGHT SAGA MARATHON W/ THE SPOOF!! Vampires Suck Full Movie Watch Along: / thereelrejects Download PrizePicks today at https://www.prizepicks.onelink.me/LME... & use code REJECTS to get $50 instantly when you play $5! Gift Someone (Or Yourself) An RR Tee! https://shorturl.at/hekk2 Now that Greg & Tara have taken in the Twilight Saga, it's time for Friedberg & Seltzer's VAMPIRES SUCK reaction, recap, commentary, breakdown, & spoiler review!!! Greg Alba & Tara Erickson react to and review Vampires Suck (2010), the outrageous parody comedy from writer-directors Jason Friedberg & Aaron Seltzer (Epic Movie, Meet the Spartans). A direct spoof of The Twilight Saga, the film leans into absurd humor, pop culture satire, and over-the-top gags to poke fun at the vampire romance phenomenon. TARA ERICKSON Follow Tara Erickson: Youtube: https://www.youtube.com/@TaraErickson Instagram: https://www.instagram.com/taraerickson/ Twitter: https://twitter.com/thetaraerickson Intense Suspense by Audionautix is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... Support The Channel By Getting Some REEL REJECTS Apparel! https://www.rejectnationshop.com/ Follow Us On Socials: Instagram: https://www.instagram.com/reelrejects/ Tik-Tok: https://www.tiktok.com/@reelrejects?lang=en Twitter: https://x.com/reelrejects Facebook: https://www.facebook.com/TheReelRejects/ Music Used In Ad: Hat the Jazz by Twin Musicom is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Happy Alley by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... POWERED BY @GFUEL Visit https://gfuel.ly/3wD5Ygo and use code REJECTNATION for 20% off select tubs!! Head Editor: https://www.instagram.com/praperhq/?hl=en Co-Editor: Greg Alba Co-Editor: John Humphrey Music In Video: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Ask Us A QUESTION On CAMEO: https://www.cameo.com/thereelrejects Follow TheReelRejects On FACEBOOK, TWITTER, & INSTAGRAM: FB: https://www.facebook.com/TheReelRejects/ INSTAGRAM: https://www.instagram.com/reelrejects/ TWITTER: https://twitter.com/thereelrejects Follow GREG ON INSTAGRAM & TWITTER: INSTAGRAM: https://www.instagram.com/thegregalba/ TWITTER: https://twitter.com/thegregalba Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, we sit down with Dave Friedberg—co-founder of Supergut, co-host of the All-In podcast, and former CEO of The Climate Corporation—to break down the science of the gut microbiome and why fiber—specifically resistant starch—plays such a critical role in optimizing it.Friedberg explains why most common probiotics fail to create lasting change, and introduces resistant starch—a powerful prebiotic—as a more effective way to support long-term gut health. He walks us through how it works, including how beneficial gut bacteria ferment resistant starch to produce short-chain fatty acids like butyrate, which are linked to improved blood sugar regulation, reduced inflammation, and increased production of GLP-1, a hormone that helps regulate appetite.We also dive into his personal philosophy on health, supplementation, and building a successful career—highlighting the non-negotiable importance of sleep and the role curiosity plays in long-term growth.GET SUPERGUT HEREDISCOUNT CODE: GUTTALKGIRLS20Follow @guttalkgirls on socials:InstagramTiktokYoutube
In this episode of The Investor Mama Podcast, host Jen Narciso sits down with money coach Carrie Friedberg, founder of SF Money Coach and author of At Peace With Money: A Holistic Roadmap to Financial Wellness. Carrie shares her personal money story — from growing up in a household where parents constantly fought about finances, to struggling with credit card debt on an $18K teaching salary in San Francisco, to ultimately transforming her relationship with money through coaching, tracking, and emotional healing. She breaks down the four levels of financial wellness — tracking, planning, analyzing, and lifelong financial literacy — and offers practical systems busy moms and families can use to take control of their finances. Whether you're drowning in debt or looking to level up your money habits, this conversation proves that mastering personal finance doesn't require a finance degree — just fifth-grade math, self-awareness, and the courage to stop avoiding the numbers. Listen now for actionable budgeting tips, bookkeeper recommendations, and the mindset shifts every mom needs to build lasting financial confidence.
About the Guest(s):Carrie Friedberg is a certified Money Coach and Financial Behavior Specialist with over 15 years of experience through her practice, SF Money Coach. She has a rich background in education, having taught kindergarten for nearly a decade. With a commitment to helping individuals and couples conquer financial challenges, Carrie brings a unique blend of counselor training and personal experience in overcoming financial obstacles. Her journey from financial struggles to empowerment has inspired her to educate others on mastering personal finance. Carrie is the author of "At Peace with Money," a book that delivers a fresh perspective on achieving financial literacy and wellness.Episode Summary:In this engaging episode of "Money Roots," host Amy Irvine sits down with Carrie Friedberg, an experienced Money Coach, to delve into the emotional and practical aspects of financial literacy. The episode explores Carrie's transformation from financial struggle to expertise, highlighting her journey and the inception of her book, "At Peace with Money." With warmth and insight, Carrie shares her personal story of overcoming fears and challenges with money, offering a relatable perspective for listeners who find financial concepts daunting.Through this conversation, Carrie and Amy discuss the critical intersection of emotions and money, emphasizing the importance of education in achieving financial wellness. Their dialogue covers Carrie's unique coaching approach, tailored to help individuals and couples navigate their personal financial journeys. Carrie emphasizes how even those without a "natural money sense" can learn to manage their finances effectively, an insight that is encapsulated in her accessible, reader-friendly book. The discussion is packed with advice on financial planning, tools, and the importance of having an advocate in financial discussions, making it a must-listen for anyone aiming to improve their money mindset and management skills.Key Takeaways:Understanding personal finance doesn't require a natural aptitude but is a skill that can be taught and mastered by anyone willing to learn.Carrie's practical and holistic approach to financial coaching involves personalized, supportive guidance through consistency and tailored strategies.Emotions and money are intricately connected; having a coach can help demystify financial concepts by breaking them down into manageable steps.Writing down financial questions and scripting for meetings can empower individuals to control their financial decisions.Carrie's book, "At Peace with Money," is designed to be an inviting and humorous guide that demystifies financial management for readers.Notable Quotes:"Proof that anyone who can do fifth grade math can master personal finance.""I wrote the book that I needed to read.""Let's just be a little more light hearted and have open hands, and turn the lights on and open the windows around money.""Everything about wealth management and personal finance is so stiff and scary.""I think anyone can figure this out."Resources:Carrie Friedberg's Book: At Peace with MoneyFinancial Recovery Institute: (Mentioned Certification)Financial Behavior Specialist Certification at Creighton University: (Mentioned Certification)Tune in to this insightful episode as Amy and Carrie navigate the journey to financial understanding and empower you to take charge of your financial wellness. Follow "Money Roots" for more enriching discussions that bridge life events with dollars and cents.
In this episode of the Wealth Architect Podcast, I sit down with Carrie Friedberg, certified psychology-informed money coach and founder of SF Money Coach. We discuss the emotional side of money, how childhood programming shapes your financial life, and practical steps to clean up your cash flow and build confidence around spending and saving. If you've ever felt stress, anxiety, or avoidance around money — this conversation will help you reset your approach.
Friday Night Flop, 16min., UK Directed by Simon Friedberg, Elliott Gerner A mother tries desperately to reconnect with her estranged daughter. https://www.instagram.com/fridaynightflop —— Subscribe to the podcast: Tweets by wildsoundpod https://www.instagram.com/wildsoundpod/ https://www.facebook.com/wildsoundpod
16 years ago a chain of Chinese restaurants wanted to increase sales without changing the price. They didn't change the product. The service. The chef. The food. Instead, they changed two words on their menu and increased sales by 18%. The restaurants used the advice of today's guest on Nudge, Robert Cialdini. Today, Cialdini explains the social proof principle, sharing how changing just two words could increase your sales. --- Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults Read Cialdini's bestseller Influence: https://amzn.to/4prHb7Y Read the new and expanded Influence: https://amzn.to/43TY0jI Read Pre-Suasion: https://amzn.to/48hA6Qr Read Yes! (Containing 60 Psyc-Marketing Tips): https://amzn.to/48ddNNf Join 10,428 readers of my newsletter: https://www.nudgepodcast.com/mailing-list Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/ --- Today's sources: Aune, R. K., & Basil, M. D. (1994). A relational-obligations approach to fund-raising: The effects of guilt and credibility appeals on compliance. Communication Research, 21(4), 486–498. Binning, K. R., Kaufmann, N., McGreevy, E. M., Fotuhi, O., Chen, S., Marshman, E., Kalender, Z. Y., Limeri, L. B., Betancur, L., & Singh, C. (2020). Changing social contexts to foster equity in college science courses: An ecological-belonging intervention. Psychological Science, 31(9), 1059–1070. Boh, W. F., & Wong, S.-S. (2015). Managers versus co-workers as referents: Comparing social influence effects on within- and outside-subsidiary knowledge sharing. Organizational Behavior and Human Decision Processes, 126, 1–17. Borman, G. D., Rozek, C. S., Hanselman, P., & Destin, M. (2019). Reappraising academic and social adversity improves middle school students' academic achievement, behavior, and well-being. Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16286–16291. Cai, H., Chen, Y., & Fang, H. (2009). Observational learning: Evidence from a randomized natural field experiment. American Economic Review, 99(3), 864–882. Frank, R. H. (2020). Under the influence: Putting peer pressure to work. Princeton University Press. Goldstein, N. J., Cialdini, R. B., & Griskevicius, V. (2008). A room with a viewpoint: Using social norms to motivate environmental conservation in hotels. Journal of Consumer Research, 35(3), 472–482. Hallsworth, M., List, J. A., Metcalfe, R. D., & Vlaev, I. (2017). The behavioralist as tax collector: Using natural field experiments to enhance tax compliance. Journal of Public Economics, 148, 14–31. Jung, J., Busching, R., & Krahé, B. (2019). Catching aggression from one's peers: A longitudinal and multilevel analysis. Social and Personality Psychology Compass, 13(4), e12440. Linder, J. A., Meeker, D., Fox, C. R., Friedberg, M. W., Persell, S. D., Goldstein, N. J., Knight, T. K., Hay, J. W., & Doctor, J. N. (2017). Durability of benefits of behavioral interventions on inappropriate antibiotic prescribing in primary care: Follow-up from a cluster randomized clinical trial. JAMA, 318(14), 1391–1392. Meeker, D., Linder, J. A., Fox, C. R., Friedberg, M. W., Persell, S. D., Goldstein, N. J., Knight, T. K., Hay, J. W., & Doctor, J. N. (2016). Effect of behavioral interventions on inappropriate antibiotic prescribing among primary care practices: A randomized clinical trial. JAMA, 315(6), 562–570. Murrar, S., Campbell, M. R., & Brauer, M. (2020). Exposure to peers' pro-diversity attitudes increases inclusion and reduces the achievement gap. Nature Human Behaviour, 4(9), 889–897. Nolan, J. M. (2021). Social norm interventions as a tool for pro-climate change. Current Opinion in Psychology, 42, 120–125. Peterson, R. A., Kim, Y., & Jeong, J. (2020). Out-of-stock, sold out, or unavailable? Framing a product outage in online retailing. Psychology & Marketing, 37(4), 535–547.
Money stress doesn't come from a lack of income; it comes from a lack of clarity, systems, and emotional safety. Certified money coach Carrie Friedberg shares how breaking the credit card cycle, building intentional savings, and staying connected to your numbers can radically change your financial life and your relationships. This episode reframes personal finance as a learnable life skill, not a moral failing, and shows how small, consistent changes lead to lasting peace with money. Key Takeaways To Listen For Why credit cards quietly keep people stuck, and when stopping their use is the fastest reset 2 savings accounts that prevent financial emergencies from turning into debt What "financial systems" actually look like and why habits matter more than formulas How money stress impacts relationships and why avoidance makes it worse over time Reasons why lifelong financial literacy matters even after you feel "stable" Resources/Links Mentioned In This Episode At Peace with Money by Carrie Friedberg | Kindle and Paperback The Let Them Theory by Mel Robbins | Kindle, Paperback, and Hardcover Online Course: Financial Wellness Foundations Quicken (Mac) Monarch About Carrie FriedbergCarrie Friedberg is a money coach and financial empowerment guide who helps individuals transform their relationship with money by addressing the emotional, behavioral, and mindset patterns behind financial decisions. Blending practical money skills with personal development, Carrie works with clients to reduce financial stress, build confidence, and create aligned, values-driven financial lives. Her approach focuses on clarity, self-trust, and sustainable habits rather than shame, restriction, or hustle-based money rules. Connect with Carrie Website: SF Money Coach Connect With UsIf you're looking to invest your hard-earned money into cash-flowing, value-add assets, reach out to us at https://bobocapitalventures.com/. Follow Keith's social media pages LinkedIn: Keith Borie Investor Club: Secret Passive Cashflow Investors Club Facebook: Keith Borie X: @BoboLlc80554
All-In with Chamath, Jason, Sacks & Friedberg: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- (0:00) Friedberg intros FDA Commissioner Marty Makary (3:21) Inside the 42 major FDA reforms in 10 months (7:51) The China Race: Winning back biotech leadership (13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines (33:13) Reshaping the failed Food Pyramid (41:29) GLP-1s and America's Obesity Epidemic (49:54) Rethinking vaccines from first principles (59:40) Lowering drug prices, the power of AI for healthcare (1:18:57) What causes autism? Follow Marty Makary: https://x.com/DrMakaryFDA Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
All-In with Chamath, Jason, Sacks & Friedberg Key Takeaways Safety remains the FDA's number one priority, but stifling innovation for “absolute safety” (which can never be achieved) also costs lives The American health establishment must respond with humility when presented with a question it doesn't know; absolutism is the wrong response The objective of the FDA should not be to fight misinformation – it should be to deliver cures and meaningful treatments faster to the American public and healthier food for children It's time to stop drugging our nation's kids at scale because they are antsy from us locking them in LED light boxes all day and shoving processed food in their faces The first step in fixing the health of America's youth is flipping the food pyramid upside down and focusing on proteinDecades of medical dogma and corruption have put together food pyramids that make no sense; the food industry's influence on academia caused the inaccurate food pyramids A top goal of the FDA is to reduce drug prices and provide better access to drugs; this will be done by encouraging competition in the marketplace and making more drugs non-prescription Read the full notes @ podcastnotes.org(0:00) Friedberg intros FDA Commissioner Marty Makary (3:21) Inside the 42 major FDA reforms in 10 months (7:51) The China Race: Winning back biotech leadership (13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines (33:13) Reshaping the failed Food Pyramid (41:29) GLP-1s and America's Obesity Epidemic (49:54) Rethinking vaccines from first principles (59:40) Lowering drug prices, the power of AI for healthcare (1:18:57) What causes autism? Follow Marty Makary: https://x.com/DrMakaryFDA Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
(0:00) Friedberg intros FDA Commissioner Marty Makary (3:21) Inside the 42 major FDA reforms in 10 months (7:51) The China Race: Winning back biotech leadership (13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines (33:13) Reshaping the failed Food Pyramid (41:29) GLP-1s and America's Obesity Epidemic (49:54) Rethinking vaccines from first principles (59:40) Lowering drug prices, the power of AI for healthcare (1:18:57) What causes autism? Follow Marty Makary: https://x.com/DrMakaryFDA Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
Tyler hosted a fireside chat with David Friedberg at last year's World Agri-Tech Innovation Summit. David discusses innovation in genetics, AI, and the current state of agtech investing. — This episode is presented by AgList, the only independent platform to discover and review ag biologicals. — Links World Agri-Tech - https://worldagritechusa.com Register using code ACRE10 - https://worldagritechusa.com/book-tickets
JCO Editor-in-Chief Dr. Jonathan Friedberg is joined by colleagues Dr. Jennifer Woyach, Dr. Wojciech Jurczak, and Dr. Matthew Davids to discuss simultaneous publications presented at ASH 2025 on pertibrutinib, a new upfront treatment option for patients with chronic lymphocytic leukemia. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Dr. Jonathan Friedberg: I'm Jonathan Friedberg, editor of Journal of Clinical Oncology, and welcome to JCO After Hours, where we are covering two manuscripts that were presented at the American Society of Hematology meeting 2025 in Orlando, Florida. I am delighted to be joined by colleagues on this call to discuss these pivotal manuscripts which cover the topic of pirtobrutinib, a new upfront treatment option for patients with chronic lymphocytic leukemia. I will first just introduce our guests, Dr. Woyach. Dr. Jennifer Woyach: Hi, my name is Jennifer Woyach. I am from the Ohio State University. Dr. Wojciech Jurczak: Hello, I am Wojciech Jurczak, working at the National Research Institute of Oncology in Krakow, Poland. Dr. Matthew Davids: Hi, I am Matthew Davids from Dana-Farber Cancer Institute in Boston. Dr. Jonathan Friedberg: We are going to start by just learning a little bit about these two trials that were both large, randomized phase 3 studies that I think answered some definitive questions. We will start with your study, Jennifer. If you could just describe the design of your study and the patient population. Dr. Jennifer Woyach: Absolutely. So this is the BRUIN CLL-314 study, and this is a phase 3 randomized trial of pirtobrutinib versus ibrutinib in patients with CLL or SLL who had not previously been treated with a covalent BTK inhibitor. The patients were both treatment-naive and relapsed/refractory, about one-third of the patients treatment-naive, the rest relapsed/refractory, and they were stratified based upon 17p deletion and the number of prior lines of therapy. The primary objective was looking at non-inferiority of overall response rate over the entire treated population as well as the relapsed/refractory patient population. Key secondary objectives included progression-free survival in the intention-to-treat and the smaller relapsed/refractory and treatment-naive populations. Dr. Jonathan Friedberg: And just comment a little bit on the risk of the patients. Dr. Jennifer Woyach: This study was fairly typical of this cohort of patients. Within the relapsed/refractory patient population, there was a median of one prior line of therapy in each of the groups, up to nine prior lines of therapy in the patients included on the study. For the overall cohort, about two-thirds of the patients were IGHV unmutated, about 15% had 17p deletion, 30% had TP53 mutations, and about 35% to 40% had a complex karyotype, which is three or more abnormalities. Dr. Jonathan Friedberg: And what were your findings? Dr. Jennifer Woyach: Regarding the primary outcome, which is the focus of the publication, we did find that pirtobrutinib was indeed non-inferior and actually superior to ibrutinib for overall response rate throughout the entire patient population and in both the relapsed/refractory and treatment-naive cohorts. PFS is a little bit immature at this time but is trending towards also being significantly better in pirtobrutinib-treated patients compared with ibrutinib-treated patients. Probably most significantly, we found this to be the case in the treatment-naive cohort where there was a striking trend to an advantage of pirtobrutinib versus ibrutinib. Dr. Jonathan Friedberg: And the follow-up that you have on that progression-free survival? Dr. Jennifer Woyach: So we have about 18 months follow-up on progression-free survival. Dr. Jonathan Friedberg: The second study, Wojciech, can you just go through the design and patient population that you treated? Dr. Wojciech Jurczak: Thank you, Dr. Friedberg, for this question. So the BRUIN CLL-313 study was, in fact, the first phase 3 study with pirtobrutinib in exclusively untreated CLL patients. It was a randomized study where we challenged pirtobrutinib versus bendamustine-rituximab. At the time we designed the protocol, bendamustine-rituximab was an option as a standard of care, and Bruton tyrosine kinase monotherapy was used far more commonly than nowadays. The primary target of the study was progression-free survival. We took all untreated patients except for those with 17p deletions. Therefore, it is a good representation for intermediate risk. We had about 60% of the population, 56 to be precise, which was unmutated, evenly distributed into two treatment arms. 17p deleted cases were excluded, but we had about 7% and 8% of TP53 mutated patients as well as about 11% and 7%, respectively, in the pirtobrutinib and bendamustine-rituximab arm of patients with complex karyotype. The progression-free survival was in favor of pirtobrutinib and was assessed by an independent review committee. What is important is that the progression-free survival of the bendamustine-rituximab arm was actually similar to the other studies addressing the same questions, like the comparison with ibrutinib in the ALLIANCE study or zanubrutinib in the SEQUOIA study. What was different was the hazard ratio. In our study, it was 0.20. It was one of the longest effect sizes noted in the frontline BTK study. It represented an 80% reduction in progression-free survival or death. If we compare it to ibrutinib or zanubrutinib, it was 0.39 and 0.42 respectively. Presumably, this great effect contributed towards a trend of overall survival difference. Although survival data are not mature enough, there is a clear trend represented by three patients we lost in the pirtobrutinib arm versus 10 patients lost in the bendamustine-rituximab arm. This trend in overall survival is becoming statistically significant despite the fact that there was a possibility of crossover, and effectively 52.9 patients, which means 18 out of 34 patients relapsing in the bendamustine-rituximab arm, were treated by pirtobrutinib. Dr. Jonathan Friedberg: I am going to turn it over to Matt. The question is: why study pirtobrutinib in this patient population? And then with these two studies, how do you find the patients that were treated, are they representative of people who you see? And do you see this maybe being approved and more widely available? Dr. Matthew Davids: I think in terms of the first question, why study this in a frontline population, we have seen very impressive data with pirtobrutinib in a very difficult-to-treat population of CLL patients. This was from the original BRUIN phase 1/2 study where most of the patients had at least two or three lines of therapy, often both a covalent BTK inhibitor and the BCL2 inhibitor venetoclax, and yet they were still responding to pirtobrutinib. The drug was also very well tolerated in that early phase experience. And actually, we have seen phase 3 data from the BRUIN 321 study comparing pirtobrutinib to bendamustine and rituximab in a relapse population as well. So I think that really motivated these studies to look at pirtobrutinib as a first therapy. You know, often in other cancers of course, we want to use our best therapy first, and I think these studies are an initial step at looking at that. In terms of the second question around the patient population, these are pretty representative patient populations, I would say, for most frontline CLL studies. We see patients who are a bit younger and fitter than sort of the general population of CLL patients who are treated in clinical practice, and I think that is true here as well. Median age in the sort of mid-60s here is a bit younger than the typical patients we are treating in practice. But that is not different from other CLL frontline studies that we have seen recently, so I think it makes it a little bit easier as we kind of think across studies to feel comfortable that these are relatively similar populations. Dr. Jonathan Friedberg: How do you see this either getting regulatory approval or potentially being used compared to current standard of care options? Dr. Matthew Davids: So my understanding is that both of these trials were designed with registrational intent in the frontline setting, and they are both positive studies. That is certainly very encouraging in terms of the potential for an approval here. We have seen in terms of the FDA recently some concerns around the proportion of patients who are coming from North America, and my understanding is that is relatively low on these two studies. But nonetheless, the datasets are very impressive, and so I think it is certainly supportive of regulatory approval for frontline pirtobrutinib. Dr. Jonathan Friedberg: I will ask Jennifer a question. The control arm in your study was ibrutinib, and I think many in the audience may recognize that newer, second-generation BTK inhibitors like acalabrutinib and zanubrutinib are more frequently used now if monotherapy is decided. How do you respond to that, and how would you put your results in your pirtobrutinib arm in context with what has been observed with those agents? Dr. Jennifer Woyach: Yeah, that is a great question. Even though in the United States we are predominantly using acalabrutinib or zanubrutinib when choosing a monotherapy BTK inhibitor, this is actually not the case throughout the entire world where ibrutinib is still used very frequently. The head-to-head studies of both acalabrutinib and zanubrutinib compared to ibrutinib have shown us pretty well what the safety profile and efficacy profile of the second-generation BTK inhibitors is. So even though we do not have a head-to-head study of acalabrutinib or zanubrutinib versus pirtobrutinib, I think, given the entirety of data that we have with all of the covalent BTK inhibitors, I think we can safely look at the pirtobrutinib arm here, how the ibrutinib arm compares or performs in context with those other clinical trials. And though we really can not say anything about pirtobrutinib versus acalabrutinib or zanubrutinib, I think we can still get a good idea of what might be the clinical scenarios in which you might want to choose pirtobrutinib. Dr. Jonathan Friedberg: And Wojciech, do you agree with that? Obviously, I think you have acknowledged that chemoimmunotherapy is rarely used anymore as part of upfront treatment for CLL. So, I guess a similar question. If you were to put the pirtobrutinib result in your study in context with, I guess, more contemporary type controls, would you agree that it is competitive? Dr. Wojciech Jurczak: Well, I think that that was the last study ever where bendamustine-rituximab was used as a comparator arm. So we should notice that smashing difference. Because if we look at the progression-free survival at two years, we have 93.4% in pirtobrutinib arm versus 70.7% in bendamustine-rituximab arm. Bendamustine-rituximab arm did the same as in the other trials, like ALLIANCE or SEQUOIA. Pirtobrutinib did exceptionally well, as pirto is not just the very best BTK inhibitor overcoming the resistance, but perhaps even more important for the first line, it is very well tolerated and is a very selective drug. Now, if we look at treatment-related adverse events, the discontinuation rate, they were hardly ever seen. If we compared the adverse events in exposure-adjusted incidence, literally all adverse events were two or three times higher in bendamustine-rituximab arm except for the bleeding tendency, which however was predominantly in CTCAE grade 1 and 2 with just 0.7% of grade 3 hemorrhage. Therefore, I think that we should actually put the best and the safest drugs upfront if we may, and pirtobrutinib is, or should be, the first choice if we choose monotherapy. Now, I understand that we are not presenting you the data of pirtobrutinib in combination with anti-CD20 or with BCL2 inhibitors, but that is to come. Dr. Jonathan Friedberg: Matt, how would you envision, were regulatory approval granted and this were an option, using this in the upfront patient population? Is there anybody who you would preferentially use this or start on this treatment? Or would this be something that you would tend to reserve for second line? Dr. Matthew Davids: So I would say that in general for most of my patients who would want to start with a continuous BTK inhibitor, I would still use a covalent BTK inhibitor, and I say that for a couple of reasons despite the very promising data from these studies. The first is that the follow-up for both of these phase 3 trials is still quite short, in the range of a median 18 to 24 months. And we know that CLL is a marathon, not a sprint, and these patients are going to probably be living for a very long time. And we do have much longer follow-up from the covalent BTK inhibitors, median of 10-year follow-up with ibrutinib and five to six years with zanubrutinib and acalabrutinib respectively. And you know, I do not think that the pirtobrutinib is going to fall off a cliff after two years, but on the other hand, I think there is a lot of value to long-term data in this disease, and that is why I think for most of my patients I would stick with covalent BTK inhibitors. But the other important factor that we need to consider is patients who are younger and may have many different CLL treatments over the years. We have to be very careful, I think, about how we sequence these drugs. We know right now that we can start with covalent BTK inhibitors and then subsequently patients will respond well to the non-covalent inhibitor pirtobrutinib in later lines of therapy. But right now we do not have prospective data the other way around. So how will the patients on these studies who progress on pirtobrutinib respond to covalent BTK inhibitors? We do not know yet. There have not been a lot of progression events, which is great, but we would like to see some data in that respect to feel more comfortable with that sequence. Now, I do think that particularly for older patients and those who have significant cardiovascular comorbidities, if they wanted to go on a continuous BTK inhibitor, I do think these data really strongly support using pirtobrutinib as the BTK inhibitor of choice in that population. In particular, the cardiovascular risks with pirtobrutinib seem to be quite low. I was very struck in the comparison with BR that the rate of AFib was equivalent between the two arms of the study. And that is really the first time we have seen that with any of these BTK inhibitors, no elevated risk of AFib in a randomized study. I think that is the population where it will get the most traction first, is the upfront, sort of older patient with significant cardiovascular comorbidities. And as the data from these studies mature, I think that we will start to see more widespread use of pirtobrutinib in the frontline setting. Dr. Jonathan Friedberg: Jennifer, I am just curious if you have any personal experience or heard anecdotally about after progression on pirtobrutinib the use of other BTK inhibitors and whether there is a growing experience there. Dr. Jennifer Woyach: I do not think that there is much clinical experience, you know, as Matt alluded to, it certainly has not been tested yet. There has been some data in relapsed CLL suggesting that in people who have resistance mutations to covalent BTK inhibitors after treatment with pirtobrutinib, sometimes those mutations go away. I think most of us are concerned that they are probably not actually gone but maybe in compartments that we just have not sampled, suggesting that sort of approach where you might sequence a covalent inhibitor after a non-covalent in somebody who had already been resistant probably would not work that well. But, you know, in this setting where people had never been exposed to a covalent BTK inhibitor before, we really have no idea what the resistance patterns are going to be like. We assume they will be the same as what we have seen in relapsed CLL, but I think we just need some longer follow-up to know for sure. Dr. Wojciech Jurczak: If I may confront Dr. Davids about the use of covalent BTK inhibitors upfront, well, I think that we should abandon the idea of using the first and the second and the third generation, at least if we don't have medical lines. If we endlessly block the same pathway, it is not going to be effective. So if pirtobrutinib gets approval in first, second line, we do not necessarily have to use it in the first line. I am not here in a position to defend that we should treat patients with pirtobrutinib upfront and not BCL2 time-limited regimen. However, the way I look at CLL patients when choosing therapy is not just how should I treat them now, but what would be the best regimen in 5, 10 years if I have to re-treat them. And in some instances, the idea may be that in this setting we would like to have a BTK inhibitor upfront to have a BCL2 inhibitor later to make it time-limited. Although I understand and I agree with Matthew that if we have an elderly, fragile population, then the charm of having a drug taken once a day in a tablet with literally few cardiovascular adverse events might be an option. Dr. Jonathan Friedberg: And I will give Matt the last word whether he wants to respond to that, and also just as a forward-looking issue, I know both investigators have implied that there will be future studies looking at combinations with pirtobrutinib, and if you have any sense as to what you would be looking for there. Dr. Matthew Davids: The field really is heading toward time-limited therapy for most patients, I would say. There is a bit of a discrepancy right now in the field between sort of what we are doing in academic practice and what is done sort of more widely in community practice. And so right now we are going to see evolving datasets comparing these approaches. We are already seeing data now from the CLL17 study with ibrutinib comparing continuous to time-limited venetoclax-based therapy, and we are seeing similar efficacy benefits from these time-limited therapies without the need for continuous treatment. And so that is where I think some of the future studies with pirtobrutinib combining it with venetoclax and other partners are so important. Fortunately, several of these studies are already ongoing, including a phase 3 trial called CLL18, which is looking at pirtobrutinib with venetoclax, comparing that to venetoclax and obinutuzumab. So I am optimistic that we are going to be developing these very robust datasets where we can actually use pirtobrutinib in the frontline setting as a time-limited therapy as a component of a multi-drug regimen. So far, those early data are very promising. Dr. Wojciech Jurczak: Perhaps last but not least, in a single center we have treated over 300 patients with pirtobrutinib. So eventually some of them relapsed. And I must say that our experience on BCL2 inhibitors, not just venetoclax but including sonrotoclax, are appealingly good. Therefore, by using pirtobrutinib even earlier, we do not block the efficacy of other compounds. Dr. Jonathan Friedberg: All right. Well, I want to thank all of our speakers. I also want to congratulate our two guests who presented these very influential papers at the ASH Annual Meeting, and chose to publish them in JCO, so we thank you for that, and Dr. Davids for your commentary - really appreciated. That is this episode of JCO After Hours. Thank you for your attention. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Disclosures Dr. Wojciech Jurczak Consulting or Advisory Role: BeiGene, Lilly, Abbvie/Genentech, Takeda, Roche, AstraZeneca Research Funding: Roche, Takeda, Janssen-Cilag, BeiGene, AstraZeneca, Lilly, Abbvie/Genentech Dr. Jennifer Woyach Consulting or Advisory Role: Pharmacyclics, Janssen, AstraZeneca, Beigene, Loxo, Newave Pharmaceutical, Genentech, Abbvie, Merck Research Funding: Company name: Janssen, Schrodinger, beone, Abbvie, Merck, Loxo/Lilly Dr. Matthew Davids Honoraria: Curio Science, Aptitude Health, Bio Ascend, PlatformQ Health, Plexus Consulting or Advisory Role: Genentech, Janssen, Abbvie, AstraZeneca, Adaptive Biotechnologies, Ascentage Pharma, BeiGene, Lilly, Bristol-Myers Squibb, Genmab, Merck, MEI Pharma, Nuvalent, Inc., Galapagos NV, Schroedinger Research Funding: Ascentage Pharma, Novartis, MEI Pharma, AstraZeneca
(0:00) Bestie intros LIVE from The Venetian Las Vegas (1:13) Epstein Files breakdown (10:06) Biggest Epstein questions: where did his money come from? (14:44) Tether's booming business (23:50) Michael Burry vs. Friedberg, Nvidia's blowout quarter and risks for 2026 (35:25) Google's Gemini 3 and TPU breakthrough (42:51) Investing your own money vs. LP capital, why Friedberg returned as a CEO (48:57) Alan Keating joins the show to talk poker strategy, thriving in chaos, risk psychology Special thanks to The Venetian Las Vegas for hosting us!: https://x.com/VenetianVegas Join us at the All-In Holiday Spectacular!: https://allin.com/events Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://x.com/RepClayHiggins/status/1990868089056219267 https://x.com/michaeljburry/status/1991289193037746579 https://polymarket.com/event/which-company-has-best-ai-model-end-of-2025 https://x.com/Similarweb/status/1988879389992386897 https://x.com/PokerGO/status/1987406318832132256
(0:00) Friedberg introduces 2025 Nobel Peace Prize Winner María Corina Machado (4:27) Venezuela before and after Chavez (15:25) Why María got involved in politics and why she was expelled (24:33) Why Maduro was chosen and Chavez's successor, China relationship, why people are fleeing (31:27) Intimidation tactics by the Maduro regime, response to claims of her being a "Western puppet" (39:30) Presidential run, election fraud, how different US regimes have viewed Venezuela (54:23) The rise of socialism in the US Follow María: https://x.com/MariaCorinaYA Learn more about the 2025 Nobel Peace Prize: https://www.nobelpeaceprize.org/articles/nobels-fredspris-2025-1 Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
(0:00) Chamath and Friedberg welcome Andrew Ross Sorkin to discuss his new book, "1929: Inside the Greatest Crash in Wall Street History--and How It Shattered a Nation" (0:38) Why he chose this time period (3:22) The setup: what led to the 1929 crash (19:24) The characters: major players in the 1929 crash; what kind of bubble are we experiencing in 2025? (26:21) Role of journalist vs market participant; characters of the 2025 market (30:10) AI's potential 1929-like impact on unemployment (35:16) Why socialism is flaring up now more than it did post-1929 (40:34) Does the US need a 2025 "New Deal" on cutting spending, tariff balancing act (46:51) Film rights strategy Buy Sorkin's new book: https://www.amazon.com/1929-Inside-Greatest-History-Shattered/dp/0593296966 Follow Andrew Ross Sorkin: https://x.com/andrewrsorkin Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://www.amazon.com/1929-Inside-Greatest-History-Shattered/dp/0593296966 https://archive.org/details/sim_ladies-home-journal_1929-08_46_8/page/n9/mode/2up
Episode 228 NPTEFF Interview with David Friedberg, PT, DPT
(0:00) Introducing Cleo Abram (1:12) Why YouTube has become the best platform for creators, techno-optimism at Huge If True (8:35) Astrophysicist Alex Filippenko on the James Webb Space Telescope (23:14) Q&A with Alex Filippenko, Cleo, and Friedberg: The universe, Fermi Paradox, black holes, NIH grants and the “war on science” (37:37) Zipline CEO Keller Rinaudo Cliffton on the future of drone delivery (53:29) Q&A with Keller Rinaudo Cliffton, Cleo, and Friedberg: Instant delivery explosion, competitors, impact on healthcare Thanks to our partners for making this happen! Solana - Solana is the high performance network powering internet capital markets, payments, and crypto applications. Connect with investors, crypto founders, and entrepreneurs at Solana's global flagship event during Abu Dhabi Finance Week & F1: https://solana.com/breakpoint OKX - The new way to build your crypto portfolio and use it in daily life. We call it the new money app. https://www.okx.com/ Google Cloud - The next generation of unicorns is building on Google Cloud's industry-leading, fully integrated AI stack: infrastructure, platform, models, agents, and data. https://cloud.google.com/ IREN - IREN AI Cloud, powered by NVIDIA GPUs, provides the scale, performance, and reliability to accelerate your AI journey. https://iren.com/ Oracle - Step into the future of enterprise productivity at Oracle AI Experience Live. https://www.oracle.com/artificial-intelligence/data-ai-events/ Circle - The America-based company behind USDC — a fully-reserved, enterprise-grade stablecoin at the core of the emerging internet financial system. https://www.circle.com/ BVNK - Building stablecoin-powered financial infrastructure that helps businesses send, store, and spend value instantly, anywhere in the world. https://www.bvnk.com/ Polymarket - https://www.polymarket.com/ Follow Cleo: https://x.com/cleoabram https://www.youtube.com/c/CleoAbram Follow Keller: https://x.com/keller Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg
SEASON 2 - EPISODE 160 - Mark Friedberg - Production Designer In this extended (and funny) episode of the Team Deakins Podcast, we speak with production designer Mark Friedberg (CAUGHT STEALING, JOKER, THE UNDERGROUND RAILROAD). A native New Yorker, it wasn't until returning to the city after Jack Kerouac-ing around the country that Mark (and his dog) first found work in the film industry as a driver for the Woody Allen production team. Mark was eventually let out of the van, and, throughout our conversation, he reveals how he thought through many of the challenges in his long and impressive career as a designer. Mark is also a staple in Barry Jenkins' (Season 2, Episode 156) stable of collaborators, and we learn how Mark's daughter convinced her father to break his own rules to initially meet with the director. We also discuss technology's place in Mark's design process, and he shares why he rehired the millennial gamers who built MUFASA's Africa to digitally visualize the sets of JOKER: FOLIE À DEUX before physically constructing them. - Recommended Viewing: THE ICE STORM - This episode is sponsored by Sandstorm & Aputure
Tim and Tyler talked with David Friedberg last year about joining Ohalo, lessons from The Climate Corp, and what will in in ag. — This episode is presented by American AgCredit. Check them out HERE. — Links Ohalo - https://www.ohalo.com Climate Corp Podcast - https://www.themodernacre.com/302-the-story-of-the-climate-corporation/ YouTube Channel - https://www.youtube.com/@themodernacre
Anna F. of Friedberg joins us to talk about the band's debut album, Hardcore Workout Queen, and why the cowbell is her favorite instrument. Plus, Friedberg performs live.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy
(0:00) Friedberg and Chamath welcome Senator Ron Johnson (2:30) The Reconciliation Bill process, how much the Big, Beautiful Bill will add to the national debt (14:33) Problems with growing our way out of debt, why elected officials are avoiding the fiscal reality (24:53) Energy rescissions, future of DOGE (32:09) How Senator Johnson will force a real review of the Big, Beautiful Bill; future of MAGA and the Conservative movement (54:15) Next steps if the Big, Beautiful Bill passes (58:35) Post-interview recap Follow Senator Johnson: https://x.com/RonJohnsonWI Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
In this episode, Jason chats with David Friedberg—CEO of Ohalo Genetics and co-host of the All-In Podcast—about how AI is transforming agriculture and startups. David introduces Ohalo's "Boosted Breeding" technology, which enables plants to inherit 100% of genes from both parents, potentially doubling crop yields. They also discuss building AI-first companies, genome language models, and the future of creativity in an AI-driven world.*Timestamps:(0:00) David Friedberg joins Jason to discuss AI Basics.(1:44) How AI leveled up hiring and operations at startups(5:46) AI and economic opportunities, complex problem-solving, and leadership's role(11:48) How to build an AI-first company culture(16:48) AI's transformative impact on biology and DNA sequencing(21:36) The “GLM” - GPT for DNA Is already in production(23:17) Biology meets AI: designing perfect plants with CRISPR and genome models(32:08) Is the “Age of Abundance” around the corner?(35:56) Democratization of creativity through AI: personalized Star Wars musicals & the future of media*Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai*Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basicsCheck out Google Cloud: https://cloud.google.com/Check out Ohalo: https://www.ohalo.com/*Follow David:X: https://x.com/friedbergLinkedIn: https://www.linkedin.com/in/davidfriedberg/*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis*Follow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com
(0:00) The Besties welcome Tim Dillon! (6:56) Nvidia H20 export controls, the China workaround, plausible deniability by chipmakers selling to China-linked entities (28:45) Trump vs. Harvard: Why the White House is threatening to take Harvard's tax-exempt status away (57:04) Hollywood's DEI facade, thoughts on AI, and more (1:18:06) Celebrity Jeopardy update: Friedberg is heading to the finals! (1:26:44) Science Corner: Mitochondrial Therapy Follow Tim: https://x.com/TimJDillon Check out Tim's new special: https://www.netflix.com/title/81992010 Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://www.youtube.com/watch?v=wUzmVo2dZNs https://www.wsj.com/livecoverage/stock-market-trump-tariffs-trade-war-04-15-25/card/nvidia-records-5-5-billion-charge-on-new-h20-export-restrictions-LXjxlqr2m80QIrfJxnYZ https://www.wsj.com/economy/trade/trump-chip-exports-nvidia-h20-china-amd-d2c4c866 https://www.reuters.com/technology/exclusive-nvidia-offers-new-advanced-chip-china-that-meets-us-export-controls-2022-11-08 https://abachy.com/news/nvidia-unveil-new-ai-chips-chinese-market-after-us-bans-a800-and-h800 https://www.moomoo.com/community/feed/compared-to-the-h100-how-is-the-performance-of-the-111725151846805 https://www.reuters.com/technology/tsmc-could-face-1-billion-or-more-fine-us-probe-sources-say-2025-04-08 https://www.bis.gov https://www.cnbc.com/2025/04/15/us-is-unable-to-replace-rare-earths-supply-from-china-warns-csis-.html https://www.bloomberg.com/news/articles/2025-03-31/trump-administration-to-review-billions-in-grants-to-harvard https://www.harvard.edu/research-funding/wp-content/uploads/sites/16/2025/04/Letter-Sent-to-Harvard-2025-04-11.pdf https://www.harvard.edu/president/news/2025/the-promise-of-american-higher-education https://apnews.com/article/harvard-trump-administration-federal-cuts-antisemitism-0a1fb70a2c1055bda7c4c5a5c476e18d https://www.cnn.com/2025/04/16/politics/irs-harvard-tax-exempt-status/index.html https://www.boston.com/news/local-news/2024/09/05/harvard-comes-in-dead-last-in-nationwide-free-speech-rankings https://en.wikipedia.org/wiki/Bob_Jones_University_v._United_States https://en.wikipedia.org/wiki/Students_for_Fair_Admissions_v._Harvard https://www.thecrimson.com/article/2022/7/13/faculty-survey-political-leaning https://www.reuters.com/world/europe/ukraines-parliament-extends-martial-law-until-august-2025-04-16 https://www.nature.com/articles/s41586-023-06537-z https://www.nature.com/articles/d41586-025-00848-z https://www.researchgate.net/publication/389907980_Organelle-tuning_condition_robustly_fabricates_energetic_mitochondria_for_cartilage_regeneration/fulltext/67d8575e478c5a3feda50563/Organelle-tuning-condition-robustly-fabricates-energetic-mitochondria-for-cartilage-regeneration.pdf https://www.foxnews.com/media/george-clooney-calls-breaking-biden-2024-his-civic-duty-says-democrats-werent-telling-truth
(0:00) Friedberg and Jason are live from Austin! (2:51) How building an audience has impacted the Besties (11:15) Colin & Samir join the Besties! (12:01) Evolution of short-form and long-form content (22:18) Business models for creatives (35:04) Advice to up and coming creators (42:10) Chris Williamson joins the Besties! (50:17) Making it seem effortless (57:47) Monetizing content (1:05:02) Scaling a one-man show (1:19:15) Bryan Johnson joins the Besties! (1:20:13) Spotify's move to video (1:21:21) Bryan's Ketamine experience (1:28:03) Creators and value props (1:36:52) Issues with the US food industry (1:43:10) Top tips for healthy living Thanks to our partners for making this happen: Gemini: Go to https://www.gemini.com/allin to get $50 in bitcoin when you sign up and trade. Function Health: Go to https://www.functionhealth.com/allin and use gift code ALLIN100 at checkout to get a $100 credit toward membership - limited to the first 1K listeners. NIAGEN Plus IVs: Visit https://www.niagenplus.com to discover the future of cellular performance. Follow Colin and Samir: https://www.youtube.com/@ColinandSamir https://x.com/ColinandSamir Follow Chris Williamson: https://www.youtube.com/@ChrisWillx https://x.com/ChrisWillx Follow Bryan Johnson: https://www.youtube.com/@BryanJohnson https://x.com/bryan_johnson Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
(0:00) Chamath and Friedberg welcome Commerce Secretary Howard Lutnick! (1:10) Howard describes his 30+ year relationship with President Trump and his road from business to politics (14:44) Running Trump's transition team, DOGE origin story, what it's like working for Trump (38:01) Balancing the budget and fixing GDP (52:21) Tariff history and strategy, global trade (1:10:34) Trump Cards, building better government software, AI thoughts (1:22:49) Sovereign Wealth Fund strategy (1:37:16) How his family reacted to his new role Thanks to our partners for making this happen: Gemini: https://www.gemini.com/allin Hims: https://www.hims.com | https://www.forhers.com iTrustCapital (use code allin): https://www.itrustcapital.com/allin Follow Secretary Lutnick: https://x.com/howardlutnick Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
(0:00) Chamath and Friedberg describe their adventures in DC and welcome Treasury Secretary Scott Bessent! (2:12) Scott's background, what drew him to equities, the role of macro investors (7:22) The legendary trade that broke the Bank of England in 1992, and how it relates to Main Street vs Wall Street today (21:30) Scott explains the Trump Administration's economic strategy (32:45) How this administration plans to de-regulate the economy, Fed relationship, re-financing debt (42:06) DOGE, DC grifts, shakeup at the IRS (50:51) Re-engineering social security through the US SWF, how energy factors in (1:00:02) Surprises, fixing affordability, thoughts on President Trump Thanks to our partners for making this happen: Hims: https://www.hims.com | https://www.forhers.com iTrustCapital (use code allin): https://www.itrustcapital.com Follow Secretary Bessent: https://x.com/SecScottBessent Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect
(0:00) The Besties intro Andrew Schulz! (3:29) Friedberg hits a quick Science Corner on the future of fertility (9:35) Reacting to Gavin Newsom's new podcast: genius or pandering? (19:36) Tariff experiment so far: risks, communication issues, and more (30:44) Why the American Dream is broken and how to fix it: cracking the housing market, social security reform (55:45) Aligning upside via increased stock market participation (1:11:23) How Andrew blew up in comedy, going direct via YouTube, building a cancel-proof following (1:22:25) State of America, conspiracy obsession, thoughts on Trump and DOGE GET TICKETS for All-In Live: Miami https://allin.com/events Follow Andrew: https://x.com/andrewschulz Check out Andrew's new special LIFE: https://www.netflix.com/title/81741999 Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://x.com/chamath/status/1895948351516131515 https://x.com/ChineseEmbinUS/status/1897132043362034153 https://electrek.co/2025/02/07/renewables-90-percent-new-us-capacity-2024-ferc https://www.wsj.com/opinion/bidens-mortgage-relief-fuels-higher-housing-prices-policy-loans-risk-cb0a1974
(0:00) Bestie intros (1:41) Epstein files first release underwhelms (4:40) Friedberg recaps his experience on Celebrity Jeopardy! (14:22) State of autonomous robots (21:06) Comparing annual reports from Stripe and Adyen; Stripe's network effects, stablecoin infra, and the pace of AI company building (29:12) State of the market: stocks, tariffs, spending bill, the "great reset" (49:07) Trump's Gold Card (56:19) Sophisticated investor test, changing accreditation laws (1:06:57) USPS, Bezos refocuses the WaPo's opinion page Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect Referenced in the show: https://x.com/bennyjohnson/status/1895195194947183047 https://x.com/adcock_brett/status/1895175400160133543 https://x.com/markjeffrey/status/1892735775550406828 https://x.com/pitdesi/status/1895117427480109238 https://x.com/jmover/status/1895129169882661100 https://coinmarketcap.com/currencies/tether https://coinmarketcap.com/currencies/usd-coin https://fred.stlouisfed.org/series/UNRATE https://www.cnbc.com/2025/02/12/cpi-january-2025.html https://x.com/StealthQE4/status/1894227465616171361 https://www.youtube.com/watch?v=7-ttACozP8s https://www.cnbc.com/quotes/US10Y https://x.com/chamath/status/1888371069322686895 https://polymarket.com/event/how-many-gold-cards-will-trump-sell-in-2025/will-trump-sell-2pt5k-5k-gold-cards-in-2025?tid=1740688723350 https://x.com/Jason/status/1706067572226244789 https://www.washingtonpost.com/business/2025/02/20/trump-usps-takeover-dejoy/ https://x.com/Jason/status/1894412028279693546 https://x.com/JeffBezos/status/1894757287052362088
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