Podcasts about Sildenafil

Maintaining your vitality and sexual health isn't just possible—it's a vital part of living your best life. In this episode, Dr. Stephen Petteruti discusses the critical elements needed for robust sexual health, such as cardiovascular fitness, testosterone balance, and mental well-being. You'll hear about cutting-edge treatments like testosterone replacement therapy, PDE-5 inhibitors such as Tadalafil and Sildenafil, and injectable therapies. He also addresses everyday issues such as performance anxiety and changing libido, offering practical advice to tackle these effectively.Take steps toward a healthier, more vibrant life today. Listen to the Intellectual Medicine Podcast —Vitality for Life: The Science Of Male Sexuality And Manhood.Enjoy the podcast? Subscribe and leave a 5-star review!Dr. Stephen Petteruti is a leading Functional Medicine Physician dedicated to enhancing vitality by addressing health at a cellular level. Combining the best of conventional medicine with advancements in cellular biology, he offers a patient-centered approach through his practice, Intellectual Medicine 120. A seasoned speaker and educator, he has lectured at prestigious conferences like A4M and ACAM, sharing his expertise on anti-aging. His innovative methods include concierge medicine and non-invasive anti-aging treatments, empowering patients to live longer, healthier lives.Website:  www.intellectualmedicine.com LinkedIn: https://www.linkedin.com/in/drstephenpetteruti/  Instagram: https://www.instagram.com/intellectualmedicine  YouTube: https://www.youtube.com/@intellectualmedicinePersonal Brand: https://drstephenpetteruti.com/ Disclaimer:  The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.

Sometimes you just need a good diversion to distract you from the dumpster fire that is modern life and few things can immediately take you on the emotional rollercoaster like a good satirical dystopian narrative so I've got first time guest Alice Darrow on with me today to help me break down what is the surprise comic book of 2025 for me, Tramps of the Apocalypse. Sitting somewhere between Faster, Pussycat! Kill! Kill! and Idiocracy, this is a hilarious dressing down of the modern manosphere through the lens of three damsels causing much distress in 2094 in a world ruled by Quest Ragnor, King Of Males as terrible dudes seek to do what terrible dudes would do in a scenario such as this. Do yourself a favor and make sure to put it on your radar. Tramps of the Apocalypse from Dark Horse Comics From the publisher The year is 2094, and men rule the world. So what has changed in seventy years, you ask? Following the ten-year Sildenafil wars of 2053, Earth has become a barren wasteland. Factions of surviving men led by “Quest Ragnor, King of Males” have taken over the remnants of cities and towns across the globe, capturing and enslaving all women…Well, all women except for three super bimbos with unparalleled bloodlust and an unquenchable thirst for violence: Baby, Belladonna, and Babette. Unwilling to bend to the whims and desires of the buffoons in charge, too slippery to be caught, and too sexy for chains, these three bangin' babes are at the top of Quest Ragnor's most wanted list. Unfortunately for him, they couldn't care less. PATREON We have a new Patreon, CryptidCreatorCornerpod. If you like what we do, please consider supporting us. We got two simple tiers, $1 and $3. Want to know more, you know what to do. ARKENFORGE Play TTRPG games? Make sure to check out our partner Arkenforge. Use the discount code YETI5 to get $5 off your order. THE LANTERN CATALOG Created on the premise of creating light in the dark, this is the the go to resource to keep you up to date on the indy projects and the creators you love. You can find them at https://www.thelanterncatalog.com/. Make sure to check out our sponsor 2000AD. Learn more about your ad choices. Visit megaphone.fm/adchoices

Der Zoll stellt regelmäßig Lebensmittel mit vermeintlich natürlichen Potenzmitteln sicher. Oft geht es um Honig, Kräuterpasten und Schokolade. Tatsächlich stecken dann aber Wirkstoffe wie Sildenafil drin – besser bekannt als Viagra. Draufstehen tut das aber nicht. Stefan Troendle im Gespräch mit Sabine Stöhr, SWR Umweltredaktion

In this video, Dr. Rena Malik delves into important topics surrounding men's sexual health in this engaging AMA episode. She discusses the effectiveness and differences between Cialis and Viagra for treating erectile dysfunction, and clarifies concerns about spontaneous erections with these medications. Dr. Malik also reviews a study linking ejaculation frequency to reduced prostate cancer risk, providing insights into potential benefits without firm conclusions. Furthermore, she offers practical advice on safe lubricant alternatives available at home and examines the impact of finasteride on prostate health and sexual side effects. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 Introduction 00:35 Cialis vs Viagra for ED 04:19 How Ejaculation Prevents Prostate Cancer 07:02 Things at Home as Lubrication Substitute 09:05 Impact of Finasteride on Prostate Health 11:34 Add cards: Prostate Meds Videos mentioned in AMA: Everything you need to know about Sildenafil vs Tadalafil for erectile dysfunction | ED pills https://youtu.be/d0ItVdi8Jkg Urologist Explains How to Use Tadalafil vs Sildenafil the Right Way https://youtu.be/SiR9AkEEpnw ED Pills Not Working? How to Make Sildenafil & Tadalafil Work for You! https://youtu.be/wgpXLBh8q2Y Scientifically Proven Ways to Make Sildenafil and Tadalafil Work Again, according to a Urologist https://youtu.be/AeskTwq6SGk Can Ejaculation Lower Your Prostate Cancer Risk? Ft. Dr. Stacy Loeb https://youtu.be/xbLwm2eyyK0 Science proves that ejaculating more often reduces your risk of CANCER?! A Urologist explains https://youtu.be/ZYhZMsvBWSU Everything you NEED to know about LUBRICANTS | What to know BEFORE you buy LUBE https://youtu.be/nTGDLjBDq8M Tamsulosin and Finasteride SIDE EFFECTS that will SHOCK YOU! | Are they reversible?! https://youtu.be/I9EeRb5m4_E Why Antidepressants Wreak Havoc on Your Sex Life?! | Urologist Explains How to Boost your Libido https://youtu.be/VqxRq5YTRWw Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices

Michael Demurjian is Chairman and CEO of Aspargo Labs, a drug development company focused on improving drug delivery through suspension-based formulation and smart device technology. Traditional pill-based drug delivery has significant limitations, with poor absorption rates and difficulties swallowing for many patients. The company's initial focus is on an oral spray formulation of sildenafil to treat erectile dysfunction that has shown rapid absorption. Suspension technology can be applied to reformulate many prescription and over-the-counter drugs to improve drug delivery, adherence, the onset of action, and user experience. Michael explains, "Here at Aspargo we have a proprietary technology, both in the suspension and in how we coat it, so that we can mask the taste of the drug itself. And so I know you're going to probably go down the path of our first drug to market, and I'll answer the next question, but masking is key because there are two things that happen with the masking. One is you make it more of a pleasant experience. People are more willing to adhere and comply than administering the drugs. If you don't, people are going to say, my goodness, that tasted horrible, and I'm not going to do that again. Or they're going to be resistant in particular children, they won't do it."  "Well, 30 years in the drug development business, and I will tell you, you bring an ED product to market where you're showing a five-minute absorption time, it captures a lot of people's attention. So we've been very well received. Our first drug to market is an oral spray, sildenafil, which is the active ingredient in Viagra. And what we've shown is a five-minute absorption time. So, it has a lovely peppermint flavor. Now, here's the key there. Sildenafil is extremely bitter. It's one of the top 20 most bitter drugs that is manufactured. Our taste is peppermint. Through the proprietary technology that we have, we've successfully bonded the flavor agents right to the molecule without damaging it. I'll tell you, it's an interesting experience. Typically, it's the medical community. But when you're looking at a drug like Sildenafil, it's a consumer experience as well." "You have to remind yourself the efficiency of absorption is critical. We look at patients, particularly in oncology, where we know that if they miss a dose of a medicine, cancers rapidly reproduce. So, missing one dose can set a patient back. What we look at and focus on is two things. One is our device to remind patients to dose their medicine. And if they forget that their physician, the physician assistant, or the office manager can intervene and text or call them saying your device just said you didn't dose. That's key." #AspargoLabs #DrugDelivery #ED #ErectileDysfunction #Sildenafil #DrugAdherence #MedTech aspargolabs.com Download the transcript here

Michael Demurjian is Chairman and CEO of Aspargo Labs, a drug development company focused on improving drug delivery through suspension-based formulation and smart device technology. Traditional pill-based drug delivery has significant limitations, with poor absorption rates and difficulties swallowing for many patients. The company's initial focus is on an oral spray formulation of sildenafil to treat erectile dysfunction that has shown rapid absorption. Suspension technology can be applied to reformulate many prescription and over-the-counter drugs to improve drug delivery, adherence, the onset of action, and user experience. Michael explains, "Here at Aspargo we have a proprietary technology, both in the suspension and in how we coat it, so that we can mask the taste of the drug itself. And so I know you're going to probably go down the path of our first drug to market, and I'll answer the next question, but masking is key because there are two things that happen with the masking. One is you make it more of a pleasant experience. People are more willing to adhere and comply than administering the drugs. If you don't, people are going to say, my goodness, that tasted horrible, and I'm not going to do that again. Or they're going to be resistant in particular children, they won't do it."  "Well, 30 years in the drug development business, and I will tell you, you bring an ED product to market where you're showing a five-minute absorption time, it captures a lot of people's attention. So we've been very well received. Our first drug to market is an oral spray, sildenafil, which is the active ingredient in Viagra. And what we've shown is a five-minute absorption time. So, it has a lovely peppermint flavor. Now, here's the key there. Sildenafil is extremely bitter. It's one of the top 20 most bitter drugs that is manufactured. Our taste is peppermint. Through the proprietary technology that we have, we've successfully bonded the flavor agents right to the molecule without damaging it. I'll tell you, it's an interesting experience. Typically, it's the medical community. But when you're looking at a drug like Sildenafil, it's a consumer experience as well." "You have to remind yourself the efficiency of absorption is critical. We look at patients, particularly in oncology, where we know that if they miss a dose of a medicine, cancers rapidly reproduce. So, missing one dose can set a patient back. What we look at and focus on is two things. One is our device to remind patients to dose their medicine. And if they forget that their physician, the physician assistant, or the office manager can intervene and text or call them saying your device just said you didn't dose. That's key." #AspargoLabs #DrugDelivery #ED #ErectileDysfunction #Sildenafil #DrugAdherence #MedTech aspargolabs.com Listen to the podcast here

Marie-Thérèse Henke, Alessandro Prigione, and Markus Schuelke get 2025 off to an informative start discussing why so many models exist for Leigh Syndrome, why we need them and how insights from disease models have led to Sildenafil being used in some patients. Disease models of Leigh syndrome: From yeast to organoids Marie-Thérèse Henke, Alessandro Prigione, Markus Schuelke https://doi.org/10.1002/jimd.12804

Der 52-jährige Eric ist voll verliebt – warum nur pocht das verliebte Herz nicht auch in Erics Unterhose? Wie hängen Herzkranzgefässe zusammen mit „Ruten", sind sie wirklich Zeiger des Herzens und wie helfen Nüsse auf Erics Speiseplan, um wieder voller Saft in den Rentierschlitten zu springen? In dieser Spezial-Episode – passend zum Samichlausentag - widmen wir uns in der Villa Margarita für einmal der Männergesundheit. Wir sprechen über volle Säcke, harte Ruten und gesunde Nüsse auf dem Speiseplan. Villa Margarita: Folge Deinem Herzen statt Deiner oder Samichlaus' Rute.

Send us a textMichael Demurjian is CEO And Chairman of Aspargo Labs ( https://aspargolabs.com/ ), which he co-founded in 2019, which is a distinguished pharmaceutical and med-tech company committed to developing innovative oral spray formulations and drug delivery systems.Mr. Demurjian brings extensive experience across finance, manufacturing, sales & marketing, logistics, and general management. He has experience in taking companies public, raising funds in public and private markets with both retail and institutional investors. Prior to Aspargo Labs, Mr. Demurjian served as COO, CFO and member of the Board of Directors of Tyme Technologies, Inc. (NASDAQ: TYME), an emerging biotechnology company developing cancer therapeutics that are intended to be broadly effective across tumor types and have tolerable toxicity profiles. At Tyme, Mr. Demurjian was instrumental in raising over 50 million dollars and obtaining a public listing on NASDAQ. He also served as CEO of Luminant Biosciences, an oncology research company studying metabolic pathways to destroying cancer cells.Throughout his career, Mr. Demurjian has successfully completed strategic transactions with G.E., Stryker, Black & Decker Corp., and Crane Cams. Mr. Demurjian currently sits on the Board of Directors of the Susan G. Komen Foundation, the NYU board of advisors and has served in the past on the Board of Directors of Luminant Bio., Mikronite Tech & KCC. #Aspargo #MichaelDemurjian #DrugFormulation #PatientCompliance #LiquidOralSuspensions #Bioavailability #Pharmacokinetics #Pharamcodynamics #Pharmacology #Adherence #Sildenafil #Dimenhydrante #Statins #Metformin #PotassiumIodide #Antiemetics #Dysphagia #MeteredDose #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Send us a textOral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial.Kallimath A, Deshpande S, Singh P, Garegrat R, Lakshminrusimha S, Maheshwari R, Suryawanshi P.BMC Pediatr. 2024 Nov 1;24(1):698. doi: 10.1186/s12887-024-05107-0.PMID: 39487423 Free PMC article. Clinical Trial.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this episode, Dr. Rena Malik, MD invites Dr. John Mulhall, to explore the complexities of erectile dysfunction (ED) and penile health. Together, they examine the use of PDE5 inhibitors like Sildenafil for young, healthy men, highlighting potential pitfalls such as psychological dependence. Dr. Mulhall also sheds light on the efficacy and challenges of intracavernosal injections for ED, emphasizing the importance of proper technique and integratability into lovemaking. Additionally, they discuss the impact of prostate cancer treatments on erectile function and orgasmic health, providing nuanced insights into the intersection of cancer therapy and sexual well-being. Listeners will benefit from an in-depth understanding of ED management, the nuances of penile health, and the broader implications of prostate cancer treatments on sexual function. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 Starting PDE5 inhibitors 01:20 Psychological dependence on medication 02:45 Intracavernosal injections & Technique errors 07:13 Medication refrigeration challenges 08:20 Erectile dysfunction post-prostate cancer 11:03 Surgery vs. radiation for ED 12:26 Modern alternate therapies 15:05 Ejaculation vs. orgasm differences Don't forget to check out Dr. John Mulhall: Instagram: https://www.instagram.com/jsmeditorinchief/ Twitter: https://twitter.com/SaveYourSexLife Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices

"HSDD" as a diagnosis has been gone for some time. According to the ACOG, the DSM-V defines the combined entity of female sexual interest/arousal disorder as a complete lack of or a substantial decrease in at least three of the following symptoms for at least six months: interest in sexual activity and sexual or erotic thoughts or fantasies. This is the most common sexual dysfunction in women, affecting an estimated 5.4–13.6% of women, based on who you read. It is most prevalent in women between the ages of 40–60 and in women who have undergone surgical menopause. Now, a new publication from the Green Journal (June 18, 2024) provides a potential “new”therapeutic option for women, although the data for this actually first came out June of 2023. Can topical sildenafil help with Female Sexual Arousal Disorder? There is already an over the counter cream like this!Let's take a look at this June 2024 RCT. PLUS, we will also briefly discuss the EROS device for female sexual arousal.

El uso  de los medicamentos  para  el  tratamiento  de  la disfuncion erectil son seguros y  eficaces sin embargo su  uso  sin acompañamiento medico, especialmente en pacientes jovenes  puede ser peligroso, en este episodio vamos a  aclarar  algunas dudas, sobre las indicacioens, dosis, resomendaciones de uso los medicamentos que  indicamos para  el manejo de la disfuncion erectil. 

From the discovery of this well-known medication, to the science behind its function, and spanning all the way to treatments for the underlying condition of erectile dysfunction as well as a complication of said treatments called priapism, this episode covers a lot of ground. As you might imagine, there will be discussions of male genitalia, the existence of sex, and sexual health in this one,  as written by Dr. Mike and presented in Poor Historians Podcast fashion. Listener discretion is advised.Sources:-https://www.space.com/24983-auroras-1989-great-solar-storm.html-https://pubmed.ncbi.nlm.nih.gov/26206161/-https://en.wikipedia.org/wiki/Priapism-https://www.mirror.co.uk/news/world-news/how-doctors-treat-impotence-before-7530711-https://www.thedailybeast.com/the-strange-true-tale-of-the-old-timey-goat-testicle-implanting-governor-Rezaee ME, Gross MS. Are We Overstating the Risk of Priapism With Oral Phosphodiesterase Type 5 Inhibitors? J Sex Med. 2020 Aug;17(8):1579-1582. doi: 10.1016/j.jsxm.2020.05.019. Epub 2020 Jul 2. PMID: 32622767.-Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov. 2006 Aug;5(8):689-702. doi: 10.1038/nrd2030. PMID: 16883306; PMCID: PMC7097805.-https://en.wikipedia.org/wiki/Sildenafil-https://en.wikipedia.org/wiki/Pulmonary_hypertension-https://www.washingtonpost.com/news/retropolis/wp/2018/03/27/the-rise-of-viagra-a-history-of-the-little-blue-pill-at-20/Goldstein I, Burnett AL, Rosen RC, Park PW, Stecher VJ. The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction. Sex Med Rev. 2019 Jan;7(1):115-128. doi: 10.1016/j.sxmr.2018.06.005. Epub 2018 Oct 6. PMID: 30301707.#medicalhistory#medicine#historyofpharmacy#viagra#priapism ----- Patreon Page (support the show) -----Submit a Question for Mike's Trivia Challenge Segment (website form with instructions)-----Podcast Linktree (social media links / reviews / ratings)-----DrMqx (Follow Dr. Max on Twitch)

Il citrato di sildenafil, principio attivo della famosa pillola blu contro la disfunzione rettile, potrebbe dimezzare il rischio di sviluppare la malattia di Alzheimer. È quanto evidenzia uno studio di un team di ricercatori del Lerner Research Institute della Cleveland Clinic, che ha collaborato a stretto contatto con colleghi di altri istituti. A Obiettivo Salute il commento del prof. Alessandro Padovani, Presidente della Società Italiana di Neurologia. Con l’esperto ricapitoliamo anche le precauzioni da adottare per prevenire o ritardare il declino cognitivo.

Welcome to the 9th & SPECIAL EASTER EPISODE of the BSCOS Paediatric Orthopaedic Digest (POD)cast with our Adam Galloway @GallowayAdam -  Physiotherapist and lead of the @BSCOS_UK AHP Committee! Adam qualified in 2013, and has always had a firm interest in paediatric orthopaedics with an MSc in Clinical Research Methods. His name is well known in the UK, working with the team in Leeds @Kidsortho_leeds and as an NIHR funded PhD investigating the non-surgical treatment of Perthes' Disease @NONSTOPPhD !!! Listen in to the episode to learn more!   We scoured 35 journals & highlighted the most impactful studies that we feel can change practice or improve outcomes in Paediatric Orthopaedics.  Follow Updates on @BSCOS_UK    REFERENCES:   1.    Health-related Quality of Life in Idiopathic Toe Walkers: A Multicenter Prospective Cross-sectional Study. Morrow et al. J Pediatr Orthop. Apr 2024 PMID: 38273462   2.    The effect of Sildenafil, a phosphodiesterase-5 inhibitor, on tendon healing: an experimental study in rat model of achilles tendon injury. Kurt et al. Arch Orthop Trauma Surg. March 2024. PMID: 38148369   3.    Is percutaneous Achilles tendon lengthening safe and effective for older children with idiopathic toe walking? Kha et al. J POSNA. Feb 2024  DOI: https://doi.org/10.1016/j.jposna.2024.100021   4.    Medial Patellofemoral Ligament Reconstruction Using Pedicled Quadriceps Tendon Autograft Yields Similar Clinical and Patient-Reported Outcomes but Less Donor-Site Morbidity Compared With Gracilis Tendon Autograft. Runer et al. Arthroscopy. Feb 2024  PMID: 37479150   5.    Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery. Kortiz et al. J Pediatr Orthop. Feb 2024. PMID: 37820062   6.    Wait-and-scan: an alternative for curettage in atypical cartilaginous tumours of the long bones. Scholte et al. Bone Joint J. Jan 2024. PMID: 38160684   7.    The Effect of Implant Density on Adolescent Idiopathic Scoliosis Fusion: Results of the Minimize Implants Maximize Outcomes Randomized Clinical Trial. Larsen et al. J Bone Joint Surg Am. Feb 2024. PMID: 37973031   8.    Rate and Risk Factors for Contralateral Slippage in Adolescents Treated for Slipped Capital Femoral Epiphysis: A Comprehensive Analysis of 3,528 Cases. Momtaz et al. J Bone Joint Surg Am. March 2024. PMID: 38271486   9.    MPFL Reconstruction and Implant-Mediated Guided Growth in Skeletally Immature Patients With Patellar Instability and Genu Valgum. Bachman et al. Am J Sports Med. March 2024. PMID: 38349668.   10. Trends in inequalities in childhood overweight and obesity prevalence: a repeat cross-sectional analysis of the Health Survey for England. Broadbent et al. Arch Dis Child. Feb 2024. PMID: 38262695   11. Reapplication of the Pavlik Harness for Treatment of Developmental Dysplasia of the Hip After Initial Pavlik Harness Failure. Tomaru et al. J Pediatr Orthop. Feb 2024. PMID: 37981894   12. Skin Antisepsis before Surgical Fixation of Extremity Fractures. he PREP-IT Investigators. N Engl J Med. Feb 2024. PMID: 38294973     Follow Hosts: @AnishPSangh @AlpsKothari @Pranai_B See those of you travelling at EPOSNA 2024 in Washington DC!!!

Men who reported taking sildenafil for erectile dysfunction also had a reduced risk for Alzheimer's disease, a recent study looking at a large number of medical records found. What about women? Johns Hopkins geriatrics expert Lolita Nidadavolu, who wrote an … Should women use sildenafil to reduce their risk of Alzheimer's disease? Elizabeth Tracey reports Read More »

Marec je vsekakor najbolj možganski mesec, če sklepamo po tem, da se marsikje po svetu odvija Teden možganov, seveda tudi pri nas. In tudi letos smo v Možganih na dlani zraven! V prvi epizodi serije se nam pridruži prof. dr. Mojca Kržan, ki bo s farmakološkega vidika pokomentirala nedavno objavljene izsledke raziskave o povezavi med zdravilom za erektilno disfunkcijo in tveganjem za razvoj Alzheimerjeve bolezni. Pripravlja: Mojca Delač.

Sildenafil, taken for erectile dysfunction, seems to have helped reduce Alzheimer's disease risk in men. Would the drug have the same impact on women, and what might the side effects look like? Lolita Nidadavolu, a geriatrics expert at Johns Hopkins … Would sildenafil work to reduce Alzheimer's disease risk in women? Elizabeth Tracey reports Read More »

Examining the medical records of more than 265,000 men has revealed that those who took the erectile dysfunction drug sildenafil experienced a reduced rate of Alzheimer's disease in comparison to those who did not. Lolita Nidadavolu, a geriatrics expert at … Can the erectile dysfunction drug sildenafil help stave off Alzheimer's disease? Elizabeth Tracey reports Read More »

Sildenafil is used by men with erectile dysfunction, with a recent study examining medical records of men who used it finding they also developed Alzheimer's disease less often. This is called an observational study, and it only can find an … The erectile dysfunction drug sildenafil may reduce the risk of Alzheimer's disease, Elizabeth Tracey reports Read More »

Men who took sildenafil for erectile dysfunction experienced less Alzheimer's disease than men who did not, a very large study looking at medical records found. One problem, says Lolita Nidadavolu, a Johns Hopkins geriatrics expert and coauthor of an editorial … How often does sildenafil need to be taken to reduce the risk of Alzheimer's disease? Elizabeth Tracey reports Read More »

Taking sildenafil for erectile dysfunction reduced the risk for developing Alzheimer's disease, a study looking at medical records of over 260,000 found.  Geriatrics expert Lolita Nidadavolu at Johns Hopkins and coauthor of an editorial on the study says there is a … How might sildenafil work to reduce Alzheimer's risk? Elizabeth Tracey reports Read More »

IMPOTENZA SESSUALE (o DISFUNZIONE ERETTILE) - Soluzioni per i PROBLEMI DI scarica ora audio mp3 DCS dal titolo NO IMPOTENZA :https://claudiosaracino.com/prodotto/noimpotenza-metododcs/#coppie #impotenzasessuale #impotenza

This is the 25th episode in drug name pronunciation series.  First, we talk about three brand-generic drug pairs: Viagra and sildenafil; Cialis and tadalafil; & Levitra and vardenafil. Then, Dr. Erin L. Albert talks about drug pricing with teamcubancard.com and costplusdrugs.com.  Erin is a pharmacist and Healthcare Innovator who works for the Mark Cuban Cost Plus Drugs Company as Vice President of Pharmacy Relations.     If you're new to my drug name pronunciation series, welcome! In this episode, I divide all six drug names into syllables, tell you which syllables to emphasize, and share the sources of my information.  Seeing the written pronunciations can be helpful.  All six are below:   sildenafil = sil DEN a fil, emphasize DEN   Viagra = vi-AG-rah, emphasize AG   Tadalafil = ta DA la fil (or my preference ta DAL a fil), emphasize DA or DAL   Cialis = see-AL-iss, emphasize AL   vardenafil = var-DEN-a-fil, emphasize DEN   Levitra = luh-VEE-trah, emphasize VEE   Thank you for listening to episode 263 of The Pharmacist's Voice ® Podcast!   To read the FULL show notes, visit https://www.thepharmacistsvoice.com/podcast.  Select episode 263.   Subscribe to or follow The Pharmacist's Voice ® Podcast to get each new episode delivered to your podcast player and YouTube every time a new one comes out!     Apple Podcasts   https://apple.co/42yqXOG  Google Podcasts  https://bit.ly/3J19bws  Spotify  https://spoti.fi/3qAk3uY  Amazon/Audible  https://adbl.co/43tM45P YouTube https://bit.ly/43Rnrjt   Sources   All three brand-name drugs have written pronunciations in their package inserts.  See section 17:  patient information.  The following links are from the FDA's website, accessed 2-1-24. Viagra package insert  Cialis package insert  Levitra package insert   The written pronunciations for tadalafil and vardenafil are in the USP Dictionary Online.  Sildenafil was not in the USP Dictionary.  For the pronunciation of sildenafil, I relied on my experience as a pharmacist and the similarities between sildenafil and vardenafil.  Thank you USP Legal Dept for permission to share your written pronunciations in my show notes and YouTube videos!   Links from this episode USP Dictionary Online (aka “USAN”)  **Subscription-based resource USP Dictionary's (USAN) pronunciation guide (Free resource on the American Medical Association's website) Dr. Erin L. Albert on LinkedIn https://linktr.ee/erinalbert  erinalbert.com teamcubancard.com  costplusdrugs.com   Praise for Dr. Erin L. Albert   Erin L. Albert is a unicorn pharmacist, and I look up to her.  We met in-person at the 2nd Annual Medipreneurs Summit in Asheville, NC in 2019.  She delivered a talk on “Thought Leadership Through Writing and Publishing.”  That weekend, Erin suggested I look into starting a podcast.  5 years later, I still remember that conversation like it was yesterday.  Thanks Erin!    If you're a pharmacist, and you don't know Erin yet, connect with her.  She's amazing!  You will find the About section from her LinkedIn Profile below (modified to third person on 2-1-24).      About Dr. Erin L. Albert Experienced licensed pharmacist, healthcare professional, educator, and attorney with a passion for transformative pharmacy and innovative healthcare solutions. Recognized for achieving substantial cost savings in pharmacy benefits, advocating for transparency, and collaborating with diverse stakeholders. A versatile writer, speaker, and leader with a track record of driving positive change in pharmacy practice, education, and policy. Committed to advancing patient care and promoting excellence in healthcare.   

Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): A randomized, double-blind, placebo-controlled phase Ib clinical trial. Wintermark P, Lapointe A, Steinhorn R, Rampakakis E, Burhenne J, Meid AD, Bajraktari-Sylejmani G, Khairy M, Altit G, Adamo MT, Poccia A, Gilbert G, Saint-Martin C, Toffoli D, Vachon J, Hailu E, Colin P, Haefeli WE.J Pediatr. 2023 Dec 21:113879. doi: 10.1016/j.jpeds.2023.113879. Online ahead of print.PMID: 38142044 Free article.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Qual a relação entre disfunção erétil e a cardiologia? Nossos pacientes podem tomar Sildenafil ou Tadalafila? Posso liberar atividade sexual após um infarto? Para começar a segunda temporada do DozeCast, o trio composto por Mateus Prata, Victor Bemfica e William Batah disserta sobre todos os tópicos relacionados à atividade sexual no paciente cardiopata.

GOAT - Dr. Irwin Goldstein He is the director of San Diego Sexual Medicine. Dr. Goldstein has had a long career providing medical help to those with sexual problems, having been involved with sexual dysfunction research since the late 1970′s. Dr Goldstein's interests include regenerative therapies for men and women, surgery for dyspareunia, physiologic investigation of sexual function in men and women, and diagnosis and treatment of sexual dysfunction in men and women. He has authored more than 360 publications in the field of sexual dysfunction, with 20 consecutive years of funding by the National Institutes of Health   Thanks to our sponsor Sprout Pharmaceuticals addyi.com/notbroken  Thanks to our sponsor Uber Lube 10% off, Code NOTBROKEN  uberlube.com  You are a urologist. I am a urologist. You are a pioneer and yet I don't even remember hearing about you during residency training. How do urologists not know who Irwin Goldstein is? He started out in men's sexual health. Dr. Goldstein tells us his story. Dr. Goldstein published the original paper on Sildenafil (Viagra) – and 90% of the phone calls after were women asking for help for them. He created ISSWSH. https://www.isswsh.org/ He was in the room when the term vulvovaginal atrophy was changed to genitourinary syndrome of menopause (GSM). Thoughts on DHEA vaginally. Women and Sildenafil – oral versus topical and his thoughts on arousal. Orgasm guidelines are coming!! The role of dapoxetine (Priligy) for inability to orgasm – you can't get this in the USA Other drugs for orgasm The role of testosterone for orgasm issues Sexual side effects of birth control pills Depression side effects of birth control pills Testosterone in women! It is a thing! Estradiol in men – needed for bones and erections. We wrap up with discussing hard flaccid. A hypogastric nerve dysfunction. Any advice for me, for other physicians, for the women and their partners? --- Send in a voice message: https://podcasters.spotify.com/pod/show/kj-casperson/message

Dr Steve, Dr Scott, Tacie discuss: Tacie gets her permit Male pattern baldness New lung cancer treatment New diabetes interventions Giant ball of ear wax Does THC affect the liver the way alcohol does? "Saturday Night Palsy" Where does "weight" go when you lose it? WTF with sildenafil? Please visit: stuff.doctorsteve.com (for all your online shopping needs!) ed.doctorsteve.com (for your discount on the Phoenix device for erectile dysfunction) simplyherbals.net/cbd-sinus-rinse (the best he's ever made. Seriously.) RIGHT NOW GET A NEW DISCOUNT ON THE ROADIE 3 ROBOTIC TUNER! roadie.doctorsteve.com (the greatest gift for a guitarist or bassist! The robotic tuner!) see it here: stuff.doctorsteve.com/#roadie Also don't forget: Cameo.com/weirdmedicine (Book your old pal right now because he's cheap! "FLUID!") Most importantly! CHECK US OUT ON PATREON!  ALL NEW CONTENT! Robert Kelly, Mark Normand, the O&A Troika, Joe DeRosa, Pete Davidson, Geno Bisconte. Stuff you will never hear on the main show ;-) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Hey Team and welcome back to the Can I Have Another Snack? podcast. We've been on hiatus but we're back with a new fortnightly pod. Today I'm talking to Dr. Asher Larmie, AKA The Fat Doctor. Asher is a transgender, non-binary GP who uses they/them pronouns. They are a fat activist and founder of the #NoWeigh campaign. Asher joined me on the Don't Salt My Game Podcast back in May last year, and we had such a great conversation that I just had to have them back for the CIHAS pod.This episode is in response to the news that the NHS/NICE in the UK are contemplating offering weight-loss injectables to kids. These drugs have already been approved in the US (which I discuss here) - it was only a matter of time before we started talking about it here too. In this episode, we talk about the evidence behind semaglutide, or lack thereof, potential side effects and unintended consequences, and of course, we talk about the company behind this drug, Novo Nordisk, who are set to make bank off of fat kids. So yeah, the first episode back is kind of a bummer - but I wanted to make sure we had a good grasp of the science before the media shitstorm kicks off. We also have a new podcast editor - the lovely from - welcome Lucy! (see if you can find the Avery Easter eggs she planted in the new episode format).Can I Have Another Snack? is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Find out more about Asher's work here.Follow their work on Instagram here and Twitter here. Listen to The Fat Doctor Podcast here.Follow Laura on Instagram here.Subscribe to my newsletter here.Sign up to my upcoming webinar with - ‘Substack for Nutrition Professionals: Launching & Growing Your Email Newsletter'. Here's the transcript in full:Asher Larmie: We had 180 teenagers for a year, and that's it. It's not enough time to understand what is going to happen to that teenager long term. We need studies that have looked back after 20 years. We need to know what's gonna happen to these kids when they become adults, when they become older adults, but not the first year. It's so dangerous. These drugs haven't existed for long enough. We've never used them in children before. It's terrifying to me. Absolutely terrifying.Laura Thomas: Hey, welcome to the Can I Have Another Snack? podcast where we talk about food, bodies and identity, especially through the lens of parenting. I'm Laura Thomas. I'm an anti-diet registered nutritionist, and I also write the Can I Have Another Snack? newsletter. Today I'm talking to Dr. Asher Larmie. Asher, who uses they/them pronouns, is a transgender non-binary GP and fat activist who is campaigning for an end to medical weight stigma.They're the founder of the #NoWeigh campaign and they have over 20 years of medical experience and have been fat for even longer than thatLaura Thomas: As the self-styled Fat Doctor, Asher started a blog in June 2020. They now also host a successful podcast and run a number of training courses, as well as monthly webinars for people who are interested in learning about weight inclusivity.Today I'm gonna be talking to Asher about the news that came out of the UK that the National Institute for Clinical Excellence, or NICE, is considering approving the weight loss injectable Semaglutide for kids. Asher is here to explain to us why this is catastrophic for kids' sense of safety in their bodies and their wellbeing.We talk about the evidence behind Semaglutide, or I suppose the lack thereof, the potential side effects and unintended consequences. And of course, we talk about the company behind this drug, Novo Nordisk, who are set to make bank off of fat kids.Just before we get to Asher though, I wanna tell you real quick about the benefits of becoming a paid subscriber to the, Can I Have Another Snack newsletter community, whole universe.Now, I know we're not used to having to pay for content on the internet, and why would you pay for something where 85% of the content is free? Well, that's a great question. I'd love to answer it for you. Well, because without paying supporters, this work just wouldn't be possible. As well as supporting me in the time it takes to research, interview contributors and write articles, your support goes towards paying guests for their time and their labour, as well as a podcast and newsletter editor. You also help keep this space ad and sponsor free so I don't have to sell out to advertisers or exploit my kid for freebies. Plus keeping the community closed to paying subscribers only means that we keep the trolls and the fatphobes out.I recently asked the CIHAS community why they support the newsletter, and this is what they had to say: “I am a mum of one, fairly adventurous, self-proclaimed vegetarian and one theoretical omnivore. The latter survives almost exclusively on added sugar and butter, but mostly sugar. I consumed all the picky eating advice, some of it really well-meaning, and pretty mellow. But by seven years in, I was more frustrated, confused, and full of self-doubt than ever. Enter CIHAS. The no-nonsense, cut through the bullshit, science-backed content is exceptional. The content about sugar is especially helpful to me, and the anti diet lens is an anecdote to my extremely anti-fat slash diet-culture conditioning. And as an American, the British references are just an added bonus to say your work is actively changing. My life is not an understatement. Thank you.” Well, thank you to the reader who shared that lovely testimonial, and if that hasn't inspired you to become a paid subscriber, I don't know what will. It's just a fiver a month or £50 for the entire year, and you get loads of cool perks, as well as just my undying gratitude for supporting my work. Head to laurathomas.substack.com to subscribe now. All right, team. Over to Asher.  Laura Thomas: So Asher, last month, the news broke that the Department of Health have recently asked the Medical Watchdog NICE. Which stands for the National Institute of Clinical Excellence to review the so-called benefits of using weight loss injectables for kids aged between 12 and 17 years old. Specifically, they're looking at the drug Semaglutide. Which has been in the news a lot recently, which I'm sure we'll get to. But I wondered if we could start by talking about what exactly Semaglutide is, how it works and what the evidence says about it. Asher Larmie: You sort of put it in air quotations, or you said so-called benefits, didn't you? I like that, yeah. Cause that, that was a really good way to start. Yeah. So Semaglutide, it's a incretin mimetic. It mimics a hormone called inncretin or one of the hormones, GLP1, which is an incretin, and, and these hormones are released by the gut in everybody's body and in response to eating. So look, you have a meal, your gut releases these hormones and they impact several parts of the body. The main thing they do is they impact the insulin pathway. So they impact the pancreas, but they also have various other effects. And one of them is they sort of decrease appetite and increase a feeling of satiety, of fullness, which makes sense, right? Because when you start eating, after a while, your body sort of wants to tell you, okay, you've been eating now like it's time to stop eating cos you can't eat forever. And when we talk about intuitive eating, we're always talking about, like, picking up our hunger cues and picking up our fullness cues. Well, there's a reason we have hunger cues and fullness cues. It's nothing to do with the size of your stomach or anything like that. It's because of these hormones acting on the appetite sensors in the brain. So this drug Semaglutide was designed for diabetics because of the way that it works on the pancreas and the insulin pathway. But they found very quickly that it causes suppression. And so people were losing weight on this drug. Their diabetics were losing weight.Laura Thomas: And to this point, just to clarify, you are talking about in adults, right?Asher Larmie: Absolutely. Laura Thomas: This research was initially done in diabetic adults?Asher Larmie: In diabetic adults. And we're talking…when they probably started working on this drug, this would've been early 2000s, I think the first one of its…the first drug in this group - and it wasn't Semaglutide, by the way, it was a completely different drug - would've come out in the sort of early 2000s. Semaglutide for diabetics, which is Ozempic, Ozempic is the brand name for the drug. Semaglutide one milligram weekly subcutaneous injection. So it comes like a little pen and you inject it into your stomach, usually. One milligram is the maximum dose for diabetics and the brand is Ozempic. I can't remember, I don't wanna say for sure, but it was definitely after 2010, somewhere around that time that we started using it in diabetics or it was approved, and more recently we've been using it in diabetics more and more and more. It's a very expensive drug, it's the most expensive diabetic drug…I dunno how it compares to insulin, but certainly compared to all the other diabetic drugs.Laura Thomas: Yeah, I saw that for like a month's supply of Wegovy, which is the, the weight loss version of Ozempic, that it costs something like $1,300 a month in the US. I don't know what it is in the UK, but in the US, $1,300 a month, that is an astounding amount of money.Asher Larmie: Sure. And that's the private prescription. But when you look in the NHS, it's how much it costs the NHS per month, right? So that's always like then.. sale price, it's, you know, it's…Laura Thomas: That's the wholesale. Asher Larmie: The wholesale, the Costco price. Laura Thomas: The Costco price! Asher Larmie: And I can't remember what it is, but it's at least twice as much. Laura Thomas: It's expensive. Asher Larmie: It's expensive. Compared to Metformin, which is probably like £1 a month. You know, in terms of diabetic drugs, it's much more expensive. Anyway, so Novo Nordisk creates Semaglutide. It's a once weekly injection. Ozempic, people like it. And then, quickly they realized it was kind of like the Viagra story. I mean, if you know the story of Viagra, Sildenafil was supposed to be for blood pressure, was anti-hypertensive for blood pressure. But they soon realised it's not so much what it does to blood pressure - in fact, it wasn't very good with blood pressure. But look at the side effects. You think something was happening to men. And so they realised, well, we could definitely corner the market here because there's no other sort of medicine that has quite the same effects. And so Viagra was born. This is very similar. Ozempic was being used on diabetics. Diabetics were losing weight, and they thought, right, let's push this through. Let's, let's turn this into a weight loss drug. And so they started studies in 2017, 2018, they started the actual study. The results came out late 2020, maybe early 2021, depending on the studies. There's been eight. And then the teenage one, so we're talking still adults only. Right. Literally within like six months, the FDA had approved it and NICE took a little bit longer. They sort of semi approved it in 2022 and fully approved it in 2023. With very, very little data. All we know is that this drug suppresses your appetite and therefore makes you lose weight. And it also does all the other things, like sort of acts on the insulin pathway and all the other things that it's known to do, but we have no idea how that impacts non-diabetics and how that will impact children, certainly. We have a zero idea. Laura Thomas: Okay, so just to summarise, cuz you're a doctor. And not everybody else is! This drug is a GLP1 analog. So it mimics a hormone in the gut that is produced naturally in response to, in response to eating a meal. Our bodies, our guts pump out this hormone. And that is one of the ways, one of the pathways, one of the signals that tells our brain, okay, we can slow down now. We've, we've got enough here, we'll be good for a little while. Right. Asher Larmie: That's it. Laura Thomas: And so we have a fall in our appetite basically. What this drug is doing, it's an external version of that hormone that you are injecting into your stomach, that artificially suppresses your appetite. Right. Asher Larmie: That's it. Laura Thomas: So it's not…it's essentially tricking your body into thinking that you've had more food than you actually have. Now this might be helpful when you have a chronic condition such as Type 2 Diabetes, it might help manage blood glucose. However, what you're saying is that we don't know what the impacts are on people who have just been prescribed this for weight loss. And we also don't know the impact of this on children who are growing.Asher Larmie: Mm-hmm. Laura Thomas: Which is…I mean, all of it is a mess. All of it is concerning and upsetting to me, but it feels particularly upsetting and concerning to me when we're talking about children, when we don't know the full scale of the impact. So what evidence do we have on children? You know, why are we at a…I mean, this is a separate conversation, but if we could get into the minds of the DoH and the NICE people, why do they think that we should start prescribing this to children? Asher Larmie: Well, first of all, we've been lied to about this drug, although I think the Department of Health and the National Institute of Clinical Excellence should be smart enough to figure out that they've been lied to about this drug. I can understand why the average person doesn't, but if you've read studies, which I have in detail, all eight of them, well, seven of them, one wasn't published, and the one on teens, it's very obvious. Because the first thing is, in order for them to achieve weight loss, the participants in this trial had to go on a diet 500 calories deficit, plus exercising for 150 minutes a week, plus an hour of counselling every month. Laura Thomas: Right, We don't know if the impact is coming from the diet and lifestyle modifications versus the drug in and of itself.Asher Larmie: We do to a degree because everybody was on the diet. Only some people were on the Wegovy. And others were on placebo, just a water injection. And so what we saw was a) that diets don't work. Which you've been saying this whole time! The diet-only group only lost about 2.5% of their body weights over a period of a year, and then regained it all. So diets don't work. What a surprise. The people who took the Wegovy definitely lost much more weight. There was a significant difference. So in the first 16 weeks, that's when you lose the most amount of weight. We know this. This is the physiological response to calorie deficits or energy deficits. It then slows down and between sort of week 16, week 20 until about month 10, it sort of slowed down, but was still going. And then at month 10 in the first study, we reached the nadir, which is the peak, and then people started regaining weight. If you look at the study over two years, people regained something like 15% of the weight that they lost within eight months. You carry that forwards….I mean, it's not particularly scientific to carry it forwards, but if you were to assume that every eight months you'd gain about 15% of the weight that you'd lost. Within five years, you've regained the weight. And that's if you are on the medication. If you stop the medication, which in the UK you only are entitled to have it for two years, the moment you stop that medication, you will start regaining the weight.There is absolutely no way you can maintain it because nobody could. Nobody could maintain it, even when they stayed on the diet. They could not maintain that weight loss. They immediately start gaining the weight back and at a rate that is almost unprecedented. We've never seen such dramatic weight loss followed by weight regain with any other weight loss drug.Laura Thomas: Well, shit, you're gonna be hungry! As soon as you stop taking that drug, like, you're gonna be fucking hungry!Asher Larmie: Sure. Although I think it's more than that. Like I don't even think that explains it. There's something else that's happening in the body and we just don't know what it is, right, to know how it's workingLaura Thomas: And this is it, like, when you go in and you start messing with hormone pathways. It's not just gonna be one individual pathway in isolation, there are gonna be knock on effects and that is what we've seen in historic weight loss medications, right? We're, we're giving people something for weight loss, but it turns out, oh, actually we're burning them alive from the inside. Right? That's what has happened with other, with other drugs…or where we've, we've tried to suppress people's appetites, but we've also suppressed their libido because again, you can't isolate out individual pathways within the human body cos everything is interconnected.Asher Larmie: That's exactly right. And actually what we know is that this drug primarily works on the insulin pathway. And the insulin pathway is extremely important for so many different reasons. We know that the insulin pathway, insulin sensitivity, insulin resistance, for example, leads to weight gains. So we could, you know, make an argument that actually once you stop messing with the insulin pathway, perhaps there is a weight regain and perhaps you are making permanent changes to the body because you are messing with the pathway you shouldn't be messing with.I, you know, I often say don't play about with a healthy organ if you can avoid it. And so in a diabetic, the pancreas is already exhausted. The pancreas is already struggling, so okay, you're gonna mess with pancreas, but it needs help anyway. Benefits outweigh the risks, but in this case, this people with a healthy pancreas, especially children, The last thing you wanna do is mess with organs that are still growing. You know that that's massively worrying. So the first thing I will say is that we have been lied to about this medication. We have been told that this medication will help you to lose weight and keep it off. Wrong. Even NICE said with the adults' guidelines, you will not be able to maintain the weight loss.So that's one thing…Laura Thomas: And can I ask you…sorry, cos I know you're like desperate to tell me your second point! But I'm just curious, like, what is the reason that NICE are giving for people only being able to stay on the drug for two years? Asher Larmie: Because that's all the evidence we have. We don't have anything beyond two years. If we had evidence for five years, they probably would've said five, but they've said, look, all you've got is two years, so that's all we can allow. Now, remember with NICE, it's the UK, this is a Nationalised Health Services, there's only a certain amount of money, so when NICE is approving a drug, they're not just worried about the drug safety, efficacy, you know, and all of that stuff. They're also worried about…is this a cost effective…yeah, it's money. Is it cost effective? So Novo Nordisk had to prove to NICE that there was a cost benefit. So helping people lose weight for two years and then regain it, which they admitted would happen because that's what their studies show. And so that's the problem if you look into that calculation, that calculation is materially flawed. The fact that NICE accepted it makes me very sceptical of the whole thing, but we can cross that bridge later. The point is that in the UK you can only have it for two years. But even if you continued it for five years, you will have regained most of the weight back by that point in time. And then they talk about maintenance doses. What maintenance dose? If the treatment dose doesn't work, then what's the maintenance dose gonna do? What does that say to me? They can only keep going up, up and up, right? At what point in time are we gonna accept that we really shouldn't be messing around with the body like that? Just for temporary weight loss. That's all it's doing. It's not improving your health. There's no evidence that it does anything for your health. It just makes you lose weight. They didn't even bother to measure the impact on your health, even your like, blood pressure, blood sugar, cholesterol. They didn't even bother to do like a statistical analysis of that, I think because they knew that they wouldn't be able to find anything. Laura Thomas: It's just so transparent, isn't it? When you say that? Like it's just, we don't actually give a shit about your health. We don't care about any other parameter of your wellbeing. We just wanna make money off of you.Asher Larmie: And so you asked, you said, well, why? Why are we trying to get this available for children? And the answer is simple: for more money. Novo Nordisk is a, you know, a traded company. They have a, a group of shareholders and they're constantly trying to improve their, you know, profit margin.And, and the thing is, when you look at all of the, if the last 15 years or so, there's been this huge push, hasn't there to -quote unquote- tackle the -quote unquote- ob*sity epidemic. And, you know, we have a -quote unquote- war on ob*sity and all these, you know, like really kind of like highly charged words.Novo Nordisk has had their hands in all of this. Novo Nordisk has fingerprints on every single article that you read in the paper. Every single PR campaign for the last 10 years. Whenever you hear the word childhood ob*sity in the, in the papers…whenever you hear that word, if you look carefully enough, you will find Novo Nordisk.They have wanted to sell this drug to teenagers for a really long time. So much so that the American Academy of Pediatrics, when they brought out their guidelines, they actually held off and waited for Novo Nordisk to be able to put their study into the, into the guidelines. Literally they were like, this is the cutoff date. And then they went, oh, hang on, hang on, hang on. Novo's not ready. Alright, let's just wait. Let's just wait. Let's just wait. Novo's ready now. Okay. We can proceed. That's how much influence Novo Nordisk has. And so it's simply about making money. The risk, the potential risk to children is really mind boggling.Laura Thomas: Yeah. So let's talk about this because there's, as far as I know, there's one study in adolescence. Is that right? Asher Larmie: That's it, yeah. Laura Thomas: Should we talk about that single study that they are basing this recommendation or this, you know, it hasn't gone through yet, but this, I mean, I mean, come on. The writing is on the wall, right. They're gonna do everything that they can to push this through. Asher Larmie: They will. Laura Thomas: First of all, let's talk about the study, and then let's talk about the implication for children, for adolescentsAsher Larmie: 180 12-17 year olds are involved in the study. There's only 180. Bearing in mind that the one for adults, the first one was 2000. 180 is actually a very low number of people. And basically it was your typical randomised controlled trials. Some got placebo, some got Wegovy. You know, they did it for 68 weeks. And then they were interested in change in body mass index. That's all they were interested in. They didn't look at anything else, and they found exactly what all of the other studies found: that in the first year, children lost weight and they lost much more when they took this drug than they did when they had placebo, just water.It's not surprising. That is what always happens. You know, when you have a drug that's going to suppress appetite, it's going to be more effective than just, you know, trying to suppress your own appetite, if that makes sense. Right. So of course it was effective, but it was only effective for the first year. That's all we've got and that's all the data. We had 180 teenagers for a year, and that's it. It's not enough time to understand what is going to happen to that teenager long term. We need studies that have looked back after 20 years. We need to know what's gonna happen to these kids when they become adults, when they become older adults, but not the first year. It's so dangerous. These drugs haven't existed for long enough. We've never used them in children before. It's terrifying to me. Absolutely terrifying.Laura Thomas: Something that I found really interesting…so shout out to Reagan Chastain, who did a really great deep dive on this, on her, Weight and Healthcare Substack, I'll link to it. But one of the things that, that she pointed out were all of the side effects that were reported in this study. A lot of them were related to gastrointestinal side effects, so a lot of nausea, vomiting, diarrhoea and abdominal pain. And so again, of course if you've got a kid who is nauseous, who has diarrhoea, if they've got that for an entire year, they're going to lose weight. But at what cost to that child? To their quality of life? To like think about if you feel sick, like even for a couple of hours during the day, let alone for an entire year. And these are kids who are presumably going to school, trying to learn, trying to have a social life, trying to navigate the headfuck that is puberty, right? All of that stuff. And we think it's a good idea to subject them to this kind of…like for why? Why?Asher Larmie: Yeah. So for me, weight loss and children is absolutely unacceptable. Always. Okay. If I see a child who is accidentally losing weight…Laura Thomas: Huge red flag, huge red flag.Asher Larmie: Massive red flag like that, that's like panic stations. Figure it out immediately. The second thing that I will say about children is that we know that dieting of any kind is going to predispose them to eating disorders, especially at that stage in life, especially at this…Laura Thomas: It is the most vulnerable point in a child's development... Asher Larmie: Absolutely. Laura Thomas: For, yeah. Yeah. The onset of an eating disorder.Asher Larmie: And we know that the more extreme their sort of dieting behaviour is, the more likely they are to develop an eating disorder. So that's the second thing. It's not just that dieting creates eating, but the more extreme…now, taking drugs is one of the most extreme form of dieting out there.So what we are doing is we are essentially prescribing eating disorders to adolescents. It is no wonder that over the last 20 years, certainly over the last few years, where we've become more and more obsessed with weight in children, where we keep sending them to these -quote unquote- weight management clinics, and we keep singling them out at school and policing what they eat and all this stuff. If you're a fat kid nowadays, like, you know, you can't even bring in a packet of crisps in your lunchbox without getting told off by your teachers. Laura Thomas: You can't even have a snack that's over a hundred calories. It's something I'm writing about at the moment and it's fucking horrendous, because we're literally policing the amount of food that a child, a growing child can have.Asher Larmie: Yeah, it's despicable. But what are we doing? More importantly, we are literally prescribing an eating disorder to them. We are saying to them, this is what's gonna happen. And are we surprised that nowadays eating disorder rates have gone up dramatically? Laura Thomas: Escalated. Asher Larmie: They're escalating in boys, they're escalating in people with like, you know, multiple marginalised identities. You know, it's not just a really thin, sort of, like, fragile teenage girl anymore that we need to be worried about. We have to be really concerned about all of these young. boys, for example, who were trying to build up muscle. It's actually quite terrifying what's happening to young people.Their mental health is really poor anyway at the moment, and what we're adding to, with this weight management, is just awful. So this isn't even about the drug. This is just about the fact that you should never mess with weights in a child. You should never, ever mess with growing organs, just let the child grow up.Laura Thomas: I wanted to ask you about, like, what are the implications of putting a child on a calorie restricted diet? Messing with their energy intake while they are growing and developing, like, what are the implications there for…around their physical development, around puberty, around sexual development, all of those things? Do we know or do we just not know?Asher Larmie: I was gonna say, first of all, it's amazing how much we don't know. No one is interested in researching this. No one ever says, what are the risks of putting a child on this medication? You know, they look at the side effects of the medication, but no one's actually said, what happens to children if you put them on diet after diet, after diet when they're young?We know the answer to this question because we are, and we are of the generation. I'm 43 years old. I was on a diet when I was a kid. I know exactly what that did to me. I weight cycled and weight cycled and weight cycled and weight cycled. It messed with me mentally. It messed with my self-esteem, my self-worth, my confidence. Instead of helping me to trust my body, it did the opposite, it took away my relationship with my body, my relationship with food, all of these things, like, it completely messed with that. So that's from a kind of like psychological point of view. But from a, from a physical point of view with these particular drugs, we don't know. We're not just worried about malabsorption. You're not getting enough nutrients if you're not eating enough food. That's, that's hugely problematic. Right? Laura Thomas: Yeah. And I know you, you say we don't know, but I think. We have a good sense, right? Like we can infer. What we would imagine would probably happen, like you say, if, if you don't have enough nutrition, if you have deficiencies. What I'm thinking about in particular is bone health and how can, you know, while you're still trying to achieve peak bone mass? You are then putting people at risk, children at risk for falls and fractures and you know, osteoporosis as they get older.Asher Larmie: Osteoporosis, anemia, you know, all sorts of things. Also gastrointestinal problems. So we are looking at things like, you know, irritable bowel syndrome and stuff that, you know, you, you mess around with the gut cos this drug, like I said…Laura Thomas: That's what you're doing. Asher Larmie: This drug impacts your appetite centres, but it also impacts your gut itself. So you're gonna mess, you know, we're talking sort of gut function and motility issues. And this is the thing that like, you know, most concerns me out of everything is, you are messing with a healthy pancreas. Now if you understand the insulin pathway, what happens with insulin is that when we ate food, sugar, insulin is released because of this incretin, right? The incretin from the gut, the GLP1 comes along, tells the pancreas: Hey, there's food here. Laura Thomas: You need to process it. Asher Larmie: And, and it goes, woo, I'm gonna release lots of insulin. So that's the pancreas and insulin. Insulin is like a key. If you put the key into the lock and you turn the lock that you open the door. Sugar can go from the blood where it's, you know, currently sitting, into the cell, which can then be used as energy for the cell, or can be stored to be used later. So you need the sugar to go from the blood, where it's useless, into the cell, where it's needed and insulin is the key. Now over time some people develop something called insulin resistance. Because you're overproducing insulin, and that's one of the first things that happen is we start overproducing insulin. Nobody knows why. It's probably genetic. You start overproducing insulin. So now there's lots and lots and lots of keys, constantly trying to turn locks and eventually the, the locks become a bit faulty, right? You keep messing around with the locks after a while, locks, you know, stop working as well. So now you can't open the door to get into the cell so there's more sugar in the blood. And eventually when you have enough sugar in the blood, you develop a condition called Diabetes, Type 2 Diabetes. At the same time, because of all this stuff that's happening, the pancreas is panicking. I keep releasing insulin, but there's still loads of sugar in the blood. What's going on? So the pancreas does what, like, you know, like what Jewish mothers do, you know? It's like, let's just keep going. It doesn't stop to think. Mm. I wonder what's going on. No, no, no. Just,  let's just keep doing the same thing and let's just… Laura Thomas: It overworks itself.Asher Larmie: Yeah. It becomes exhausted. As any organ would. After a while it becomes knackered. We call it pancreatic exhaustion. At that point in time, you are also going to, it's also gonna have implications and you'll develop Type 2 Diabetes. So here's my thing. This drug is making you secrete lots and lots of insulin. Because like you said, it's fake incretin, so you're injecting it into your skin. All of a sudden you have lots more of this, you know, a mimic of this hormone in your blood at all times. So your body starts producing more and more insulin. Now as it produces more and more insulin. If you're a diabetic, this is great cos you need the insulin. But if you are not a diabetic, you're producing all of this insulin. Keep producing it, keep producing, keep producing. Isn't it possible, theoretically, that you could actually be speeding up the process of insulin resistance? And so what you could be doing is you could be speeding up the process of developing Type 2 Diabetes. So isn't it possible - and it's just the theory cos there's no evidence. But isn't it possible that, if we give a 12 year old this drug and they take it for say, five years, because by that point in time they'll be allowed to take for five years, they've taken it five years and then they start to develop insulin resistance, and maybe by the time they're in their twenties they've got quite profound insulin resistance and then they get diabetes at 26 say, and people think, gosh, diabetes at 26, that's quite young, but you know, they are fat, so it's their fault they've been fat, so they were kids, so it's their fault.This would be…it wouldn't surprise me and we wouldn't be able to do anything about it by then. So I'm not saying that this drug is going to cause diabetes. I'm just saying that it is theoretically possible that it could cause diabetes because excess of insulin is the first step of insulin resistance and diabetes progression.So this is really worrying and nobody is addressing this. It also interferes with the cholesterol pathway and all sorts of other things. So my worry is that it's actually making things worse rather than better. Laura Thomas: And it sounds as though Novo Nordisk are not asking those questions.Asher Larmie: There's no mention of this anywhere in their literature, I have to say. Nobody's asking, and this is what I can't understand. right. I'm a GP. I am not an expert. There must be people out there who understand the process of insulin resistance and they're thinking, Hmm, logically this makes sense. I wonder if we need to look into it. But I never hear anyone talk about it.And I remember the first time. I brought it up with Greg Dodell, who is an endocrinologist. I remember the first time I said, are we not worried about this? And he was like, no, of course not. Because you know it, it reduces insulin resistance. And I was like, no, no, no. It, it reduces insulin resistance in diabetics, but what about in healthy people long term? Shouldn't we be worried about this? And I remember at one point in time Greg going, oh. No one, no one said this before. I was like, why is no one talking about this? But nobody is, and that's just one of my many concerns. It also causes pancreatitis, acute pancreatitis. Which is a life-threatening condition.There's no evidence that causes pancreatic cancer. I just wanna point out, but we also don't have enough long-term data to say whether it does or it doesn't. So that is an absolute, we couldn't say, you know, we couldn't possibly comment. Laura Thomas: Even, you know, regardless of what the long term implications are, which..obviously there is not enough research going on to establish that, but even the short term impacts on children, you know, again, some of those side effects that were reported in the study we were talking about were gallbladder problems, gallstones, low blood pressure, itching, rash, like all kinds of side effects on top of the nausea, vomiting, diarrhoea, headache, abdominal pain, all these other things. And I just… there is no rationale that I think you could convince me of where that is a good idea, to subject children to that. And you know, and that's without knowing the answers to…what about their growth? What impact is this gonna have on their development? Without knowing any of that. Asher Larmie: When we are making a recommendation, right, there's two things we look at. Number one is the quality of the evidence. The quality of the evidence here is shit. The second thing we have to understand is, are the benefits, do the benefits far outweigh the risks?If the benefits don't outweigh the risks, or if the benefits are sort of similar to the risks then we shouldn't be recommending this, this, any medication. Not only is the evidence shit, but there are no proven benefits apart from temporary weight loss. And there are so many risks. Some of them hypothetical, but as you say, some of them very real and very immediate.So if that's the case, there is never a reason to give this drug to a child, never, ever, ever, especially because, yes, they are able to consent, but only if they're given all of the information and aren't being pressured into it by external, external people and, and unfortunately they just won't have that ability. They won't have the agency over their body to say, no, I know I'm fat, but I'm not taking this medication. Most of them won't feel that way. So no, I don't think…we have a consent issue here. We have all sorts of issues. Laura Thomas: I think it's an important point is that kids are gonna feel pressured into it, both from medical anti-fat bias, as well as just anti-fat bias that is everywhere, that they're gonna feel from their peers, that they're gonna feel from their parents, that they're gonna feel from teachers. Yeah. Like, I can also understand why this drug is so attractive to so many people if it reduces the stigma that they're experiencing. Even if it is temporary and even if it has a really high price tag associated with it.Speaking of price tags, The Guardian reported earlier this month that Novo Nordisk, so the company that makes Wegovy, paid more than £21.7 million to UK health experts and organisations in just three years, according to Disclosure UK records. And then several of those experts and organizations went on to make submissions to NICE, supporting the drug's approval for use in adults. It just, again, shows you that enormous conflict of interest within Novo Nordisk. But like we said before, the, the writing's kind of on the wall in terms of this getting pushed through NICE. And, you know, being incorporated into NICE guidelines.What does that process look like from here? Like what happens between now and then? And you know, how can we intercept, you know, where do we submit evidence and submit concerns and ask these questions? Can we even do that? Or is this just gonna go through? Asher Larmie: The can we is tricky actually. It's not the kind of process where you can get involved as as easy as you'd like to.Laura Thomas: It's not like a public consultation, basically. Asher Larmie: It's not. What will happen is that NICE has to make a decision about whether they're going to look into it first. And then they will form a guidelines committee. NICE will have a group of…it doesn't have to be doctors. It'll be, uh, experts. And some of them will be more interested in data and some of them will be interested in finances and some of them will be doctors and not necessarily pediatricians or endocrinologists. They could be psychiatrists, they could be anything. And they're just members of the panel. So you get this little guideline committee and then you've got your stakeholders. And so there will be certain groups that will be invited to partake. Obviously Novo Nordisk is gonna be… Laura Thomas: At the table.Asher Larmie: …doing the big presentation. In the adult one we had Ob*sity UK, a charity that is funded by Novo Nordisk. We had another ob*sity charity, whose name I can't quite remember, but again, is funded by Novo Nordisk. We had Professor John Wilding, who is the lead author of the Step 1 trial, the Wegovy Trial who has been paid countless times… Laura Thomas: Handsomely. Asher Larmie: Handsomely by Novo Nordisk. And that was basically it. There was nobody not representing, Novo Nordisk. And so they go through like you know, the beginning and people were asked to submit evidence and then you know, there are questions and then they have to submit more evidence and then they have the draft guidelines.And there is probably a time when you can get involved and register your concerns. But I don't think it's open to the public. I don't believe, to my knowledge, that it's open to the public. I think that if this does happen, we are going to have to consciously, and by we, I mean the kind of people who are, you know, advocating against this drug being used in children are going to have to consciously get together and find a way to get involved in this process.I wasn't with it enough when NICE was looking at Wegovy, it was too early on. It wasn't far enough into my sort of, I guess, deliverance… Laura Thomas: Activism. Asher Larmie: Deliverance, I would say more! From, from diet culture and weight stigma, but certainly this time around we're gonna have to do something about it. It's absolutely unacceptable, but to be honest, I would like it not to get that far.The Guardian, the Observer, have been writing a few political pieces about the politics of Novo Nordisk. And they have in the UK had a bit of a slap on the wrist. I don't think they're taking it very seriously. I don't think they're worried about it, but they have been caught doing some very unethical things. We're not surprised. They are very aggressive in their marketing campaign. And you know the, how much did you say it was? 20 million.Laura Thomas: Yeah, 21.7 million.Asher Larmie: It's nothing compared to how much they spent in America. That was 150 million or something. Like, it's nothing. I'm not going to, for one second defend my colleagues cos I don't have time for that. But I do think a lot of them will have been going to weight management courses, conferences, and conferences, whatever. And not realised that because, because Novo Nordisk was not outspoken. They weren't like, we are Novo Nordisk and we are presenting this data to you. They ran these courses without telling them yeah, that they were running these courses.And so a lot of my colleagues are fanatical about this drug and also, again, most of my colleagues learn a lot of medicine from reading the Sun and the Daily Mail, and maybe not the Sun or the Daily Mail. Maybe my colleagues are too high brow for that. You know? They're far too snobby to read the Sun or the Daily Mail. But they're reading it in the paper. They're reading their stuff in the paper. They're not reading.Laura Thomas:  They're reading, like, Henry Dimbleby talk about ultra processed food. Like yeah, he knows what the fuck he's talking about. Asher Larmie: How many, how many fat people have gone to see a doctor and they've been recommended, oh, you should try keto because, you know, that worked for my uncle, or something stupid like that.Like, you know, doctors really have no clue when it comes to nutrition, when it comes to -quote unquote- weight. Um, what do they call it? Laura Thomas: Weight management. Asher Larmie: Weight Management, right? So they just say stuff, they repeat stuff they've read in the papers. So they've all got it in this head that this is a miracle drug because of this beautiful PR campaign.Now, if I worked in public relations, I would be massively impressed. But as a doctor who is conscious of the fact that this drug is going to massively harm children and is already massively harming adults, I am horrified that this is the society that we live in. So we have to do something about this. We really do. But all we can do is educate at the moment, because I don't know how much more political power we have.Laura Thomas: I'm counting on you, basically Asher, to send up the bat signal and when it's time for us to fuck shit up, just let me knowAsher Larmie: We're keeping a close eye. Again, shout out to Reagan. She's amazing and she has been keeping on top of what's happening in the UK, and the politics with no, because obviously, Reagan, I, I learn a lot of, I learned most of my stuff from Reagan, but there are a group of us around the world that are doing whatever we can to, to shed some light on the very dark, underhanded dealings of this company.And because she's keeping abreast of what's happening in the UK, the one good thing I can say about it's the UK is that it's a lot more out in the open. Yes. You know, the FDA, it's all done behind closed doors and there's, there's no legislation, there's no, there's no legal requirements to do things a certain way.But if you've noticed the ABPI, which stands for something to do with pharmaceutical industry and their main organisation, has kicked Novo Nordisk out and given them a really, you know, has given them a telling off because of the ethics, because of what they've done and how unethical it's been.So this is my point. I think we also need to be exposing them for the fraudsters that they are. And anyone and everyone can do that. My friend Jeanette, who is The Mindset Nutritionist, she just wrote a Substack newsletter where there was an article, uh, that was in the papers last week about how, how much fat people are costing the NHS.Laura Thomas: I saw this.. Asher Larmie: Yeah And Jeanette basically is like, she talked about it and at the end she was like, oh, by the way, this person's funded by Novo Nordisk. And it's like, oh, there you go. You can find Novo's name anytime you try and look into it. So, you know, if you're sitting at home thinking, what can I do about this? Feel free to do a little bit of sleuthing, like Googling by yourself and try, just try and find the name, Novo Nordisk. Google the name of the doctor that's quoted in the article, and then Google Novo Nordisk  and see where you can find the connections. Cause I think the more we bring attention to this, the, the more we expose these fraudsters for who they are.Laura Thomas: Right? Any investigative journalists listening. You know, hit Asher up. Asher Larmie: Yeah. I'm totally on board. That's it. I'll give you my number.Laura Thomas: What you're saying is that we, we need to kind of make a noise about how unethical and dubious all of this is. And, and how devastating this could be if it, if it goes through, so yes.Okay, well, we'll see how this all plays out. If you haven't signed up to Reagan's newsletter and Jeanette's newsletter, I'll make sure that I've linked to both of those in the show notes so that you, you know, we can watch out for developments. And of course I'll link to Asher's social media and everything so you can, you can follow his work as well.Asher Larmie: I am in the process of bringing out a book about this. So if you're interested in finding out a little bit more, it's a little ebook, everything that we've talked about, but in much more detail. So, yeah, keep your eye out.Laura Thomas: All right, Asher, to wrap up at the end of every episode, we share what we have been snacking on.So it can be an actual, literal snack if you want, or just something that you've been really vibing on, something you're really interested in and you wanna share with the audience, a book, a podcast, whatever. What do you have for us? Asher Larmie: Mine's a book. It's called, It Was Always Ours by Jessica Wilson.Laura Thomas: Oh, yeah. We had Jessica on the podcast talking about her book.Asher Larmie: Oh, oh. Well then I'm not bringing any new revelation. I dunno what she said, but I absolutely love this book.Laura Thomas: You can give it a plug and I'll link, I'll link to the episode as well.Asher Larmie: It's such a good book. It's great. I found it a very easy book to read. You know like sometimes when you read non-fiction books, it feels heavyLaura Thomas: There's so many like pop culture references, that I think it just make it feel really like relatable and understandable. She digs into Goop. That's brilliant. Asher Larmie: And it's funny! Really funny. Really funny. Like it keep, it keeps you laughing until the end.There was like one chapter at the end where she's talking about goop, where I was literally rolling around giggling. It's a really insightful book when it comes to just how anti-fatness has played out, especially within the black community. Cause it's a, it's a book written by a black woman for black people, for black women.But I think there's so much to learn from reading this book, so cannot plug this book enough. Love it, love it, love it, love it, love it. And I think I've read it three times now. .Laura Thomas: Oh wow. Okay. So you're a Stan.Asher Larmie: Re-snacking. Re-snacking on it.Laura Thomas: I love it. Yeah, no, Jessica is great. And I'll link to the episode that we had her on cos it was a really good conversation. All right, so my thing, little less high brow than Jessica's book. I was telling you before we started recording that tomorrow is my kid's third birthday. And so over the weekend we put up his birthday tree. A birthday tree - for people who have not been following my Instagram stories over the past couple of years - is a Christmas tree. Except it's pink and covered in fake snow that I put up for my birthday, my husband's birthday and Avery's birthday. And I just think it's the most fun tradition, we have, like all his little birthday presents underneath it, and it kind of gets you in like the birthday spirit. And I'll put probably some like little lights and stuff on it. So yeah, I have this giant fucking pink Christmas tree in my living room and it's so festive and cheery. Do you wanna see it? Should I show?Asher Larmie: Yeah. No, but is it like a…oh my gosh. It's like a full size. I was thinking like a little mini one.Laura Thomas: No, no, it's like…yeahAsher Larmie: And look at all those presents. Laura Thomas: I know. Asher Larmie: How did you manage to keep those unwrapped, like, you know, they're sitting under the tree not being messed with, I don't think my kids would've been that sensible.Laura Thomas: Well…Yeah. I don't know. Actually, I think that next year we'll probably have a bigger problem. He's like, he's pretty chill. Like he'll..I think.. he does ask can we open them? And, and we're like, no. Well, it's your, it's, it's not quite your birthday yet, but yeah. If it was me, I'd be in, I'd be like pushing… like, what's this? What's this?Asher Larmie: Little tear in the wrapping.Laura Thomas: Peeking in between the wrapping paper. My snack, what I'm snacking on is birthday trees and I think everyone should get involved in this tradition. Asher, can you let everybody know where they can find you and your work online?Asher Larmie: Yes, head to fatdoctor.co.uk and there you will find not only my socials, but all of the classes that I'm running, all of the courses that I'm running. I do one-to-one consulting. If and when the book…the book will come out and when it comes out, you'll be able to see it all on my website. So I think that's probably the central place. I'm also on Instagram, but like I said, if you go to fatdoctor.co.uk, you'll be able to find me on all my socials as well.Laura Thomas: We are gonna link to all of your places on the internet in the show notes anyway, so people will be able to, to find you. Thank you so much for coming and having what I think is a really important conversation.You know, I think the media are presenting one side of the story. Like you said, there's a couple of journalists who are doing some sleuthing and that's really good work, but it's not going far enough. And I think we need to alert parents, teachers, other doctors, medical people to the really concerning dark underbelly of, you know, the Novo Nordisk, Wegovy Industrial complex, whatever you wanna call it.Asher Larmie: Yeah. Well said. Laura Thomas: So thank you. Thank you so much, Asher. Asher Larmie: Thank you.Laura Thomas: Thanks so much for listening to the Can I Have Another Snack? podcast. You can support the show by subscribing in your podcast player and leaving a rating and review. And if you want to support the show further and get full access to the Can I Have Another Snack? universe, you can become a paid subscriber.It's just £5 a month or £50 for the year. As well as getting tons of cool perks you help make this work sustainable and we couldn't do it without the support of paying subscribers. Head to laurathomas.substack.com to learn more and sign up today. Can I Have Another Snack? is hosted by me, Laura Thomas. Our sound engineer is Lucy Dearlove. Fiona Bray formats and schedules all of our posts and makes sure that they're out on time every week. Our funky artwork is by Caitlin Preyser, and the music is by Jason Barkhouse. Thanks so much for listening. ICYMI this week: Fundamentals: Helping Kids build a Good Relationship with Sugar - Part 2* Fundamentals: Helping Kids build a Good Relationship with Sugar* 19: AMA w/ Jeanette Thompson Wesson* Rapid Response: Why I don't like ‘this food does a little/this food does a lot' This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit laurathomas.substack.com/subscribe

Women make up half of the globe's population, but the dollars devoted to finding treatments for women's unique health issues—beyond conditions such as breast cancer—are significantly underfunded. Only 1 percent of research dollars are invested in women's health concerns, and women's health represents only 2 percent of the development pipeline of preclinical products for non-cancer related conditions, according to a 2022 McKinsey & Company report. Sabrina Martucci Johnson, president and CEO of Daré Bioscience, says this is not congruent, at all, with the need and demand for such products and the fact that women account for 80 percent of consumer purchase decisions for healthcare.   “A lot of the women's health indications are conditions that are simply just a part of being a woman. They're not life threatening, but they're life altering in many cases,” Sabrina says. This gender gap in product development motivated Sabrina to found Daré Bioscience (pronounced Dah-ray and meaning "to give" in Italian) in 2015, which is focused on finding novel treatments for women's health issues—encompassing reproductive, vaginal, and sexual health—and bringing them to market. In this episode of LifeLines—airing just before National Women's Health Week—we delve more into these healthcare inequities and learn about how Daré is addressing these unmet health needs with its product pipeline. The company's first FDA-approved product, Xaciato, came out in 2021, and Daré is in its Phase 3 clinical trial for a monthly hormone-free contraceptive, in collaboration with Bayer—the only company that's built an over billion-dollar contraceptive brand. It's also in Phase 2 for its product Sildenafil, a treatment for female sexual arousal disorder.   Sabrina shares the challenges of raising capital when you're one of the first in your field, despite having proof of concept, and how three mentors (and a chance encounter on an elevator) were instrumental in launching Daré. You can follow Sabrina Martucci Johnson and Daré Bioscience on LinkedIn.  LifeLines is produced by Biocom California, the leader and advocate for life science in California and beyond. To learn more about us, visit ⁠biocom.org⁠ or engage with us on ⁠Twitter⁠ and ⁠LinkedIn⁠. For a transcript of this episode, you can download it ⁠here.⁠ Interested in becoming a member or joining us on this podcast? Email ⁠podcast@biocom.org⁠.  Host: Chris Conner Executive Producer: Marie Tutko Senior Producer: Vincenzo Tarantino Associate Producer: Lauren Panetta Program & Research Coordinator: Katy Burgess Transcripts By: Jessica Schneider Senior Director of Marketing: Heather Ramsay Graphic Design By: Raquel Papike

In this episode, we review the high-yield topic of Sildenafil/Vardenafil from the Reproductive section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

Viagra, Cialis e Levitra, a cosa servono? a cosa NON servono? quando sono pericolosi? Anche se stiamo parlando di farmaci "iconici" e super conosciuti dalle persone, sono davvero pochi i pazienti che utilizzano il sildenafil, il tadalafil e il vardenafil in maniera consapevole per la sua unica indicazione nell'ambito dei disturbi sessuali, ovvero la Disfunzione Erettile.Gli inibitori della fosfodiesterasi-5 (PDE-5) sono farmaci che sono stati sviluppati per il trattamento della disfunzione erettile negli uomini. Tuttavia, negli ultimi anni, questi farmaci sono stati utilizzati in modo improprio da alcune persone per scopi diversi da quelli per cui sono stati approvati.Sildenafil, Tadalafil e Vardenafil sono stati anche usati in modo improprio per scopi ricreativi, soprattutto da parte di giovani adulti che vogliono sperimentare l'effetto del farmaco sulla propria sessualità.Tuttavia, questo tipo di utilizzo può causare problemi di salute, come la dipendenza psicologica dal farmaco, la pressione sanguigna bassa e la tachicardia.Prima di passare a questo video su Viagra & Co. è importante sottolineare che l'uso di questi farmaci deve essere sempre supervisionato da un medico e che non dovrebbero essere assunti da persone che non ne hanno bisogno oppure acquistati sul mercato nero o sul web in maniera illegale. #sildenafil #tadalafil #vardenafilIl Dr. Valerio Rosso, su questo canale YouTube, si dedica a produrre delle brevi lezioni di psichiatria rivolte ai pazienti, agli operatori della salute mentale, ai famigliari dei pazienti, agli studenti di medicina, agli specializzandi in psichiatria e a chiunque sia interessato alla salute mentale, alla psichiatria ed alle neuroscienze. ISCRIVETEVI AL MIO CANALE ► https://bit.ly/2zGIJorScoprite tutti i miei libri: https://bit.ly/2JdjocYScoprite la mia Musica: https://bit.ly/2JMqNjZVisitate anche il mio blog: https://www.valeriorosso.comAvete mai sentito parlare del progetto psiq? Andate subito ad informarvi su https://psiq.it ed iscrivetevi alla newsletter.

En este video revisamos la farmacología del sildenafil también conocido como viagra, el tadalafil conocido como cialis y otros medicamentos en el grupo de inhibidores de la fosfodiesterasa.Checa el video aquí: https://youtu.be/p_lb9iBys3cVisita nuestra tienda en línea para comprar nuestros libros y material educativo:https://bit.ly/3i6eAnGSi necesitas una consulta aquí nos puedes encontrar:http://bit.ly/3aUSt12Ayúdanos a encontrar los mejores hospitales para estudiar:https://bit.ly/36o82LXUnete al equipo de Mecenas en YouTube desde 1 dolar al mes: http://bit.ly/2O1AtsXEncuentra más información en nuestro Instagram: https://bit.ly/3gX0zflSupport the show

This interesting science-based query has come from CH Arun, who expressed his curiosity in knowing whether one can take Minoxidil lotion while using sildenafil (Viagra) at the same time. Arun informed Dr John Watts that he has been using 5% Minoxidil for hair growth and recently, a doctor advised him to use Viagra for his Erectile Dysfunction problem. But, is it advisable? Will there be any adverse side effects if one takes the two at the same time? What are the side effects? What is the truth? Should one follow precautions before using the two if there are side effects? In this interesting educational video, Dr John Watts – a noted dermatologist, trichologist and hair transplant surgeon in Hyderabad – explores the possible fallout of using both Minoxidil and Viagra. He has performed over 2000+ hair transplant procedures. Introduction: Sildenafil – better known by its brand name Viagra – is also known as the ‘blue pill' that is prescribed for those diagnosed with Erectile Dysfunction (EDs). “What is common between topical Minoxidil lotion and Viagra is that both are blood vessel dilators that help in increasing blood supply: Minoxidil increases blood supply to the hair roots on the scalp, while Viagra does the same for male sexual organ,” explained Dr John Watts. In particular, Minoxidil also helps in supplying nutrients to the hair roots that help in better hair growth Both drugs also help in sup Using them together: What you should know While answering the most important question raised by Arun at the beginning, Dr John Watts said that both drugs are prescription drugs that should not be used without consulting experts. “It is better to avoid using the two drugs at the same time as much as possible as both are blood vessel dilators (vasodilators) and can lead to complications for the users,” advised Dr John Watts. Side-Effects: Before explaining their side effects, Dr John Watts said that if one takes the Viagra pill 30 minutes before sexual intercourse the drug shows its impact by increasing blood flow to the male sexual organ. However, if one starts taking the two together, there could be several complications. “In fact, Minoxidil itself shows side effects on some people when taken alone. Hence, when such people start taking Viagra at the same time, the complications can increase further,” warned Dr John Watts.

Small animal internist, Dr. Jillian Haines, author of "A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs in: American Journal of Veterinary Research Volume 83 Issue 4 (2022) (avma.org)", discusses sildenafil as a treatment for generalized megaesophagus in dogs. Hosted by Associate Editor, Dr. Sarah Wright, and Editor-in-Chief, Dr. Lisa Fortier.INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA OR AJVR?JAVMA: https://avma.org/JAVMAAuthorsAJVR: https://avma.org/AJVRAuthorsFOLLOW US:JAVMA:Facebook: Journal of the American Veterinary Medical Association - JAVMA | FacebookInstagram: JAVMA (@avma_javma) • Instagram photos and videosTwitter: JAVMA (@AVMAJAVMA) / Twitter AJVR: Facebook: American Journal of Veterinary Research - AJVR | FacebookInstagram: AJVR (@ajvroa) • Instagram photos and videosTwitter: AJVR (@AJVROA) / TwitterJAVMA and AJVR LinkedIn: https://linkedin.com/company/avma-journals#VeterinaryVertexPodcast #JAVMA #AJVRINTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

Go to www.brooklinen.com and use promo code [tiger20] to get $20 off plus free shipping on your purchase of $100 or more. When you want to be a better problem solver, therapy can get you there. Visit www.betterhelp.com/belly today to get 10% off your first month. Just go to www.getroman.com/belly Generic Viagra (aka Sildenafil) for just $4 per dose

Bill rambles about the Louisville Slugger factory, his super hero idea, and punk kids. Fenway Merch: https://silkshopstores.com/billburrmerch/shop/products/all?page=1 Butcher Box:  Sign up today at www.butcherbox.com/BURR and use code BURR to get one 10-14lb Turkey FREE in your first box.  Roman: Just go to www.GetRoman.com/BURR today for generic Viagra (aka Sildenafil) for just $4 per dose.

  Vidcast:  https://youtu.be/lDf7Ochu6Gg   The FDA and Distributor RFR, LLC announce the recall of SANGTER Energy Supplement.  This supplement contains undeclared sildenafil, the generic name for the erectile dysfunction drug Viagra, making it an unapproved drug with unproven safety and effectiveness.  This supplement is a danger for those taking any nitrate-containing drugs such as nitroglycerin as the sildenafil, a phosphodiesterase, may cause a dangerous drop in blood pressure.  Do not use this supplement, and contact RFR at 1-305-989-5472 or via email at info@sangter.com to arrange for a refund.   https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/distributor-rfr-llc-voluntary-nationwide-recall-sangter-energy-supplement-due-presence-undeclared   #sangter #supplement #sildenafil #nitrates #hypotension #nitroglycerin  

  Vidcast:  https://youtu.be/5DOOVk3ibx0   The FDA and shopaxx.com are recalling Kingdom Honey Royal Honey VIP.  This food product contains sildenafil, the active ingredient in the erectile function drug Viagra.  Sildenafil may interact with prescription drugs containing nitrates including nitroglycerin and trigger a significant blood pressure drop.  This honey is being promoted and sold for sexual enhancement on the website shopaxx.com, but it constitutes an unapproved medication with unproven safety and efficiency.  If you bought this honey, do not consume it.  Instead mail it back to Shopaax.com, 2 Burleigh Court A5,Newark, DE 19702 for a refund.  For more information, contact shopaxx.com at 1-302-276-4406.   https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/shopaaxcom-issues-voluntary-recall-kingdom-honey-royal-honey-vip-due-presence-undeclared-sildenafil   #shopaxx #honey #sildenafil #nitrate #nitroglycerin #hypotension #recall

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s always, feel free to send us questions, comments or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through instagram or twitter, @nicupodcast. Or contact Ben and Daphna directly via their twitter profiles: @drnicu and @doctordaphnamd. Papers discussed in today's episode are listed and timestamped below.enjoy!________________________________________________________________________________________Show notes and articles can be found on our website: www.the-incubator.org/060-journal-club-29/This podcast is proudly sponsored by Chiesi and by Reckitt/Mead-Johnson

How does dapagliflozin affect kidney outcomes in patients hospitalized with COVID-19? Find out about this and more in today's PV Roundup podcast.

I get into my mindset and why I felt how I did the last time I J-O'd. One word tattoo, ASMR chicks I love, Tadalafil vs Sildenafil and being horny in church. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Dreams are a comment on the events of the day, with a lot of advice and guidance thrown in. Yeah, I heard you say that before Michael. I'm not sure I see it though.  Well, you're in luck. Today's show includes 3 dreams that give advice on career and are a perfect demonstration of this principle. Now if you're thinking, "Career is boring", let me ask you this. What could Viagra possibly mean in a career dream?   Do you want to know what your spiritual gifts are? “Yes”, is the right answer. Well, we have the course that you need. On it we interpret 2 of your dreams to tell you what your gifts are. Go to https://www.dream-analysis.com/april to find out more   If you want your dream analyzed on my show, you can submit it here https://www.dream-analysis.com/podcasts/contact.htm   And when you do submit a dream that I use on my show, you get a bonus private call with me to talk about it.   Dream: Helping a dying person Sadie is on the phone to 2 doctors to help a person who is dying. They direct her to a hospital where she is to get Sildenafil, the main ingredient in Viagra, and Tetragrammatride.   Dream: Skateboarding home using my arms Sadie is kneeling down on a wide skateboard and using her arms to propel herself forward.  Show Archives https://www.dream-analysis.com/podcasts/    Courses https://www.dream-analysis.com/courses

1998. La France gagne la coupe du monde de foot et le Viagra est mis sur le marché. Une année faste pour la masculinité ! Ce médicament contre l'impuissance est connu pour avoir été découvert par hasard. Le laboratoire Pzifer le testait pour soigner l'angine de poitrine et c'est un effet secondaire sur les érections qui a retenu leur attention. Mais il a un autre effet secondaire, moins connu, sur les règles douloureuses. Ça par contre, ça n'a pas franchement intéressé le labo ... Dans cet épisode, Marine-Pétroline te raconte l'histoire de ce célèbre médicament et comment la médecine et les tests cliniques peuvent être biaisés en faveur des hommes. Tu comprendras mieux ce qui cloche dans nos sociétés et pourquoi l'égalité c'est pas encore gagné. Tu auras des billes pour répondre à ceux qui te disent le contraire.Pour aller plus loin :

  Vidcast:  https://youtu.be/V395dwF4DTs   Short Shorts are quickie reports about cutting edge medical and healthcare discoveries.  They're worth knowing about this 2nd week of April, 2022.   CAR-T chimeric antigen receptors have proven effective immunotherapy for blood system cancers such as leukemias.  They haven't worked as well on solid tumors.  Now a Dutch research group working with BioNTech, the developers of the Pfizer CoVid vaccine has found that CAR-T cells kill solid cancers better when they are sensitized to the protein CLDN6 that is found on the surfaces of testicular, ovarian, and endometrial cancer cells.  That sensitization can be now accomplished using mRNA.  A phase 1 trial of 14 patients with advanced cancers showed a 86% response rate.  Very promising.   https://aacr.ent.box.com/s/c5vdgvlj128qojzmuqgwuj2uz8mipqsy     There is a sweet spot for bedtime if you want to have the lowest risk of cardiovascular disease.  A UK study of over 88 thousand Brits shows that those hitting the bedsheets between 10 and 11 pm have a 25% lower risk of heart disease compared with those turning in between midnight or later and a 12% lower risk compared with those retiring for the night between 11pm and midnight.  These numbers are most statistically significant for women.  You'll have to record your favorite late night talk shows.     University of Pittsburgh developmental biologists have identified a drug cocktail that promises to save the 30% of infants with hypoplastic left heart syndrome who typically die before their first birthdays.  One of the drugs in the cocktail is tauroursodeoxycholic acid or TUDCA, used to treat liver disease, and the other is  sildenafil, better known as Viagra and used to treat erectile dysfunction.  These two drugs together help normalize the defective metabolic processes that otherwise lead to progressive heart failure and death in these babies.  The Viagra turns up mitochondrial function in heart muscle cells while the TUDCA prevents the enhanced metabolic activity from overheating these cells.  This therapeutic approach could save many infants who cannot get a heart transplant.       The licorice extract glycyrrhizin is a compound that has been used by healers dating back to ancient times for its anti-inflammatory and antioxidant effects.  Biomedical scientists at the University of Illinois are now testing it as a therapeutic agent for the prevention and treatment of cancer.  The compound also has antiviral effects, and others have tested it as an anti-CoVid drug.  Don't go wolfing down sticks and sticks of licorice though as glycyrrhizin can raise your blood pressure to dangerously high levels.   https://www.sciencedirect.com/science/article/pii/S1043661822000834?via%3Dihub#!     There you have the latest reveals for the 2nd week of April, 2022.  When additional information about these developments becomes available, I'll pass it on to you.     #CAR-T # CLDN6 #bioNtech #bedtime #cardiovascular #hypoplasticleftheart #sildenafil #viagra #tudca #licorice #cancer #covid    

Es wird immer deutlicher, dass Long-Covid Potenzstörungen verursachen kann und das nicht nur, weil die Durchblutung des Penis leidet. Auch psychische, hormonelle und neurologische Ursachen spielen eine Rolle. An diesem Punkt bringt Chris ein neues (altes) Wundermittel ins Spiel: Viagra gegen Corona! Eine faszinierende Vorstellung - und nicht einmal unrealistisch!

Martin fühlt sich abhängig von Viagra. Seit 3 Jahren nimmt er vor fast jedem Sex eine Pille und hat trotzdem Schwierigkeiten mit der Erektion, Ängste und Scham. Er ist jung, gesund und fit – wo ist also das Problem? Gemeinsam sprechen wir darüber und ich gebe ihm Tipps aus meiner Erfahrung als Coach und als Genesener. Check für alle Rein&Raus Termine und Tickets: http://reinundraus.com/sex-workshops/ Rein&Raus Website, Events & Newsletter: www.reinundraus.com Spende und supporte: www.patreon.com/reinundraus

“Hey Ya”. Jeff Bezos and The Challenger. Superwoman solves North Korea. New Orleans Vampires. Xenomorph rampages through New York. Breakfast habits. Beta blockers, and the great Tom Experiment. Hair growth = small penis. Sildenafil flush reaction. ”Far From Any Road” - The Handsome Family ”Let the Mystery Be” - Iris DeMent ”Corona” - Minutemen