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Girls Gone WoW keeps the Warcraft community in the know from a fresh perspective. Join #teampositive and their plethora of guests from the community each and every week! Simes is back with us this week to talk about hero talents! Are they bringing you the class fantasy you were promised?? Bit of a mixed bag I think. Check it out! We hope you enjoy the show – if you want to be a guest you can get in touch with us on Discord by joining us at bit.ly/ggw-discord or email us at girlsgonewowpodcast@gmail.com Find this episode and many others at https://www.bonusroll.gg/directory/girls-gone-wow/
What's better than The Sims 4? The Sims 4 multiplayer! Welcome to the future of The Sims 4, because we aren't getting The Sims 5 anytime soon... Yes, that's right. The future of the franchise is multiplayer. Somehow. EA have claimed they don't want the Simes players to lose any progress, and so will continue to milk, uh, we mean support, The Sims 4 for a very long time. It has nothing to do with the obscene amounts of money all the add-ons are generating at all. Nope, EA is operating out of the goodness of their heart. Thanks EA, for allowing us the privilege of paying you. Over and over and over again. Ara: History Untold leads this week's new games, and boy does it look good! We're eating good in the Xbox camp, no matter where you play - with Frostpunk 2, Ara, and Worms Armageddon exploding onto every screen Microsoft owns. Maybe buying up half the industry is starting to pay off? Or maybe we're just in a golden age of games, games and even more games. All this and more in this week's episode of The Regular Show. -- For previous episodes, our socials, community events, and more, visit ⭐THE XBOXCAST OFFICIAL WEBSITE ⭐
PREVIEW: RUSSIA: PROPAGANDIST Comment by colleague Josh Rogin of the Washington Post regarding a dual US-Russian citizen, D. Simes, charged by the DOJ for alleged offenses such as money laundering and sanctions violations -- perhaps because he is a Russian propagandist on Russian TV. More details to follow. 1818 Moscow
Last month, the FBI raided the homes of Scott Ritter, a former United Nations weapons inspector and critic of American foreign policy, and Dimitri Simes, a former think tank executive and an adviser to Donald Trump's 2016 presidential campaign. In late August, The New York Times reported that these searches were part of the U.S. Justice Department's “broad criminal investigation into Americans who have worked with Russia's state television networks.” In the past two weeks, U.S. officials have taken numerous measures against Russia Today and its affiliates and accelerated police actions against Russia-based individuals and entities accused of covert influence operations, including money laundering, sanctions violations, and unregistered foreign agent work. For example, the Justice Department announced the seizure of 32 Internet domains used in Russian government-directed foreign malign influence campaigns (colloquially referred to as “Doppelganger”), alleging that Russian companies used online domains to impersonate legitimate news entities and unique media brands to spread Russian government propaganda covertly, violating U.S. laws against money laundering and trademarks. That same day, the Justice Department indicted two Russia-based employees of RT for conspiring to commit money laundering and conspiring to violate the Foreign Agents Registration Act in a $10-million scheme to fund and direct a Tennessee-based company to publish and disseminate information “with hidden Russian-government messaging.” A day later, officials charged Dmitri Simes and his wife with participating in a plot to violate U.S. sanctions and launder money obtained from Russian state television. About a week later, the U.S. State Department issued a special “alert to the world,” declaring that new information obtained over the past year reveals that Russia Today has “moved beyond being simply a media outlet” and has become “an entity with cyber capabilities” that's “also engaged in information operations, covert influence, and military procurement.” Washington claims that the Russian government embedded within RT in Spring 2023 an entity “with cyber operational capabilities and ties to Russian intelligence.” Based on these allegations, Meta — the parent company of Facebook, Instagram, and WhatsApp — soon announced that it had banned Russia Today and its affiliates from all its platforms. A day before that big announcement from the State Department, a jury in Tampa, Florida, convicted four American citizens of conspiracy to act as agents of the Russian government. Case evidence first reported by RFE/RL shows that the activists on trial secretly coordinated their activities and received funding from “Anti-Globalization Movement” head Alexander Ionov, who acted on orders from Russia's Federal Security Service. To discuss this recent explosion of American police and diplomatic activity targeting RT and Russian covert influence operations in the U.S., The Naked Pravda spoke to RFE/RL journalist Mike Eckel, who coauthored the September 6 report on how Ionov and his FSB handlers “chatted and plotted to sow discord in the United States.” Timestamps for this episode: (5:54) The U.S. government's coordinated campaign against Russian covert influence operations (7:18) Legal strategies when prosecuting Moscow's malign activities (8:37) Alexander Ionov and the FSB (15:11) American activists and Russian covert operations (18:52) “Foreign agency” in the U.S. vs. in Russia (32:12) Dmitri Simes and Channel One (36:18) Scott Ritter and Russia TodayКак поддержать нашу редакцию — даже если вы в России и вам очень страшно
This week: Judge Merchan has postponed sentencing and his ruling on whether some of the evidence in the case is subject to presidential immunity; Donald fails another time to remove the case to federal court; plus updates on Simes, Tenet Media, and E. Jean Carroll.Mike Nellishttps://twitter.com/mikenellisAuthentic Digital Strategyhttps://www.instagram.com/authentic.hq Thanks to ExpressVPN for supporting our show!Get an extra 3 months free. Expressvpn.com/cleanup.Allison Gillhttps://muellershewrote.substack.com/https://twitter.com/MuellerSheWrotePete Strzokhttps://twitter.com/petestrzokThe Podcasthttps://twitter.com/aisle45podWant to support this podcast and get it ad-free and early?Go to: https://www.patreon.com/aisle45podTell us about yourself and what you like about the show - http://survey.podtrac.com/start-survey.aspx?pubid=BffJOlI7qQcF&ver=short
Friday, September 6th, 2024Today, Judge Merchan will NOT postpone Trump's sentencing set for September 18th; Special Counsel argued for immunity briefs in a hearing with Judge Chutkan today; one of the right wing influencers who took Russian money has been fired; the Teamsters Union has agreed to meet with Kamala Harris on September 16th; former Trump campaign advisor Dmitri Simes has been indicted for skirting Russian sanctions; Kamala Harris has agreed to muted mics during the September 10th debate; the FBI has searched the homes of three more top advisors to New York Mayor Eric Adams; and Allison and Dana deliver your good news.Go to JOINdeleteme.com/Dailybeans and use promo code Dailybeans for 20% off. Guest:John Fugelsanghttps://www.johnfugelsang.com/tmehttps://podcasts.apple.com/us/podcast/the-john-fugelsang-podcast/id1464094232The Sexy Liberal Save The World Comedy Tourhttps://sexyliberal.comHave some good news; a confession; or a correction to share?Good News & Confessions - The Daily Beanshttps://www.dailybeanspod.com/confessional/From The Good Newshttps://shop.votevets.org/products/im-a-veteran-not-a-sucker-or-a-loser-yard-signhttps://www.blackpearlbookstore.com/ Check out other MSW Media podcastshttps://mswmedia.com/shows/Subscribe for free to MuellerSheWrote on Substackhttps://muellershewrote.substack.com Follow AG and Dana on Social MediaDr. Allison Gill https://muellershewrote.substack.comhttps://twitter.com/MuellerSheWrotehttps://www.threads.net/@muellershewrotehttps://www.tiktok.com/@muellershewrotehttps://instagram.com/muellershewroteDana Goldberghttps://twitter.com/DGComedyhttps://www.instagram.com/dgcomedyhttps://www.facebook.com/dgcomedyhttps://danagoldberg.comHave some good news; a confession; or a correction to share?Good News & Confessions - The Daily Beanshttps://www.dailybeanspod.com/confessional/ Listener Survey:http://survey.podtrac.com/start-survey.aspx?pubid=BffJOlI7qQcF&ver=shortFollow the Podcast on Apple:The Daily Beans on Apple PodcastsWant to support the show and get it ad-free and early?Supercasthttps://dailybeans.supercast.com/OrPatreon https://patreon.com/thedailybeansOr subscribe on Apple Podcasts with our affiliate linkThe Daily Beans on Apple Podcasts
Ma vie de néo-vigneron, entre installation et premiers millésimes by RadioVino
Girls Gone WoW keeps the Warcraft community in the know from a fresh perspective. Join #teampositive and their plethora of guests from the community each and every week! There's been changes to M+ announced this week, and we have Simes with us to help us work out what they mean as the comms was…questionable. We hope you enjoy the show – if you want to be a guest you can get in touch with us on Discord by joining us at bit.ly/ggw-discord or email us at raven@girlsgonewow.net Find this episode and many others at https://www.bonusroll.gg/directory/girls-gone-wow/
One pest control expert is defending sparrow extermination in the name of 'health and safety'. Daily Bread's Point Chevalier branch in Auckland has faced backlash after members of the public spotted poisoned birds outside the establishment. Smash'd Em Pest Control Manager, Jonathan Simes, says it's a necessary move to prevent the spread of germs and disease. "We need to weigh up the pros and cons on whether we want germs and disease from the droppings in our food, or around us as we eat- or a clean environment." LISTEN ABOVESee omnystudio.com/listener for privacy information.
Two former wizards on the podcast today.Gillian Cosgriff and David Simes. Gillian the queen of quizzes and former guest.David Simes. Hater of all things quiz related and podcasts.Listen to see how this goes down.Go See 'Actually, Good' - Gillian's 'Best Show' Award winning show. Find dates at her instagram @gilliancosgriffSupport this show http://supporter.acast.com/the-saturday-quiz. Hosted on Acast. See acast.com/privacy for more information.
In the topic of fencing in a roof, Rabbeinu Bechayai teaches that we all signed up for our life situations during the original 6 days of creation. Explore some philosophical and practical applications of this idea. Quote how Mrs. Simes was inspired by this idea, and how it transformed her ability to handle the challenges her family was dealt. You can hear her story here. The Rolling Rabbi: Interview with Mrs. Shaindel Simes - YouTube Have a good Shabbos.
This was a fun interview...Tom Simes got his start as a standup comic later in life...old like 39...Ha! Anyway, after over 5 years as a comic, he had the opportunity to start his own comedy club...and did! In addition, from his analytical mind he saw that many comics didn't understand the Business side of it all, so he started the podcast: The Business of Comedy Podcast...available on the StandupComedyPodcastNetwork.com. I know you will enjoy this conversation!Hosted by: R. Scott EdwardsA brief explanation about the subscription service and why it is there and what it offers. In addition, a direct way to contact me and share viewpoints and ideas.Support the showwww.StandupComedyPodcastNetwork.comhttps://www.facebook.com/scottscomedystuffWrite a Review: in-depth walkthrough for leaving a review.Subscribe and get Bonus Shows and entire inventory of Shows: https://www.buzzsprout.com/838567/subscribe
Antonella y Aldana Simes son hermanas y colegas y colaboran regularmente con fotógrafos, modelos, artistas, y publicaciones. Ambas trabajaron en distintas marcas argentinas y hace un tiempo lo hacen desde Paris. En el marco del último BAF Week el dúo presentó el primer desfile argentino en el metaverso. Nacidas en La Falda, Provincia Argentina de Córdoba, desde muy pequeñas sabían que de grandes trabajarían juntas y que no sería diseñando ropa sino ayudando a definir la manera en que se percibe, crea y concibe la moda.
Jo Fellas! Ein weiterer Monat steht in den Büchern und auch wenn wir uns zuletzt nur mit Cokerap beschäftigt haben, hatte der vergangene Monat Mai auch vieles anderes am Start. Wir sprechen über das OG Keemo Comeback, die erste Appearance von Kendrick Lamar nach seinem Abgang von TDE, das neue und anscheinend letzte Peter Fox-Album, und noch viel mehr. Checkt die Folge gerne ab, genießt den Feiertag; startet danach gut in die Woche und seid lieb zueinander!
LB Johnson Of SUAT Sits Down With Big Gemini & Unlmted Data to Talk Humble Beginnings, Their Music & Their Connection To Super Producer Simes Carter --- Support this podcast: https://podcasters.spotify.com/pod/show/ShutUpAndTalk/support
Inspiration for Parshas Vayikra
Une occasion rêvée de mieux comprendre comment la start-up Ramify peut permettre à ses clients de souscrire aux meilleurs fonds de la planète en matière de Private Equity grâce à un partenariat avec Altaroc. Au travers des parcours de ces deux jeunes sociétés, nous découvrons des solutions ultra innovantes qui donnent accès à un grand nombre de clients à une classe d'actifs totalement sous représentée dans les portefeuilles. Mes deux invités : Frédéric et Olivier nous partagent le set-up qui se cache derrière ces deux offres. Vous verrez de quels fonds il s'agit, comment l'accès est rendu possible, et comment fonctionnent ces deux équipes qui oeuvrent avec passion et détermination. C'est aussi l'occasion de revenir sur les expériences solides de ces deux entrepreneurs en matière de gestion : PE d'un côté et quantitative de l'autre. C'est assez épatant pour être honnête.
Extrait de l'épisode de Dimanche. Une occasion rêvée de mieux comprendre comment la start-up Ramify peut permettre à ses clients de souscrire aux meilleurs fonds de la planète en matière de Private Equity grâce à un partenariat avec Altaroc. Au travers des parcours de ces deux jeunes sociétés, nous découvrons des solutions ultra innovantes qui donnent accès à un grand nombre de clients à une classe d'actifs totalement sous représentée dans les portefeuilles. Mes deux invités : Frédéric et Olivier nous partagent le set-up qui se cache derrière ces deux offres. Vous verrez de quels fonds il s'agit, comment l'accès est rendu possible, et comment fonctionnent ces deux équipes qui oeuvrent avec passion et détermination. C'est aussi l'occasion de revenir sur les expériences solides de ces deux entrepreneurs en matière de gestion : PE d'un côté et quantitative de l'autre. C'est assez épatant pour être honnête.
Mrs. Shaindel SimesTeacher and author of The Rolling Rabbi When life throws us punches, we can make a conscious decision: will we bow to them or roll with them? The Simes family chose to roll with them.On that fateful summer day, as Rabbi Simes stood davening minchah, no one could have known that this would be the last time he would stand on his own feet. That evening, a terrible car accident turned his family's life upside down. With Hashem's kindness, everyone survived, most with only light injuries – except for Rabbi Simes. The young father and lecturer was severely injured. And life for the Simes family would never be the same.Rabbi and Mrs. Simes rose above their incredible challenges, and for several years, Rabbi Simes became “the Rolling Rabbi.” In his new capacity, he continued to teach and inspire. Unfortunately, he eventually succumbed to his injuries, and Mrs. Simes now carries on his legacy.With this podcast, you will be inspired and awed at how a family is able to embrace life, laugh and lovingly accept extremely challenging circumstances.https://www.chevrahlomdeimishnah.org/product/i-wish-someone-would-have-told-me-a-book-for-teens-who-have-lost-a-parent/
Ned Simes is one of Australia's biggest up-and-coming fashion and party photographers. He is also one of my best mates.Ned has spent the last 8 years traveling the world chasing a good time and perfecting his craft.A few key topics in this chatNed's childhoodHigh school and athleticsMountain bike passionCamp America!?Love of PhotographyHow to build a happy lifeI loved this chat and so will you!Ned's socialshttps://www.instagram.com/nedyo/?hl=enCamp Americahttps://www.campamerica.com.au/Cooper's SocialsInstagram - https://www.instagram.com/cooperchapman/?hl=enTik Tok - https://www.tiktok.com/@cooperchapman_?lang=enGood Humans PodcastInstagram - https://www.instagram.com/goodhumanspodcast/?hl=enUse code PODCAST for 25% off. Made for those who like to think a little differently about mental health...SHOP MERCH HERE - https://www.thegoodhumanfactory.com/collections/allEnquire about a workshophttps://www.thegoodhumanfactory.com/pages/workshopsCooper@thegoodhumanfactory.comInstagram - https://www.instagram.com/thegoodhumanfactory/?hl=enWebsite - https://www.thegoodhumanfactory.com/Wellbeing Network 2022. See acast.com/privacy for privacy and opt-out information.
Ned Simes is one of Australia's biggest up-and-coming fashion and party photographers. He is also one of my best mates.Ned has spent the last 8 years traveling the world chasing a good time and perfecting his craft.A few key topics in this chatNed's childhoodHigh school and athleticsMountain bike passionCamp America!?Love of PhotographyHow to build a happy lifeI loved this chat and so will you!Ned's socialshttps://www.instagram.com/nedyo/?hl=enCamp Americahttps://www.campamerica.com.au/Cooper's SocialsInstagram - https://www.instagram.com/cooperchapman/?hl=enTik Tok - https://www.tiktok.com/@cooperchapman_?lang=enGood Humans PodcastInstagram - https://www.instagram.com/goodhumanspodcast/?hl=enUse code PODCAST for 25% off. Made for those who like to think a little differently about mental health...SHOP MERCH HERE - https://www.thegoodhumanfactory.com/collections/allEnquire about a workshophttps://www.thegoodhumanfactory.com/pages/workshopsCooper@thegoodhumanfactory.comInstagram - https://www.instagram.com/thegoodhumanfactory/?hl=enWebsite - https://www.thegoodhumanfactory.com/Wellbeing Network 2022. Hosted on Acast. See acast.com/privacy for more information.
Ned Simes is one of Australia's biggest up-and-coming fashion and party photographers. He is also one of my best mates.Ned has spent the last 8 years traveling the world chasing a good time and perfecting his craft.A few key topics in this chatNed's childhoodHigh school and athleticsMountain bike passionCamp America!?Love of PhotographyHow to build a happy lifeI loved this chat and so will you!Ned's socialshttps://www.instagram.com/nedyo/?hl=enCamp Americahttps://www.campamerica.com.au/Cooper's SocialsInstagram - https://www.instagram.com/cooperchapman/?hl=enTik Tok - https://www.tiktok.com/@cooperchapman_?lang=enGood Humans PodcastInstagram - https://www.instagram.com/goodhumanspodcast/?hl=enUse code PODCAST for 25% off. Made for those who like to think a little differently about mental health...SHOP MERCH HERE - https://www.thegoodhumanfactory.com/collections/allEnquire about a workshophttps://www.thegoodhumanfactory.com/pages/workshopsCooper@thegoodhumanfactory.comInstagram - https://www.instagram.com/thegoodhumanfactory/?hl=enWebsite - https://www.thegoodhumanfactory.com/Wellbeing Network 2022. Hosted on Acast. See acast.com/privacy for more information.
Today's guest on The Kingdom Driven Entrepreneur Podcast is Pat Simes, Founder and CEO of Innovative Business Solutions, and one of our Kingdom Driven Entrepreneur certified service providers. While Pat shares that she had a strong relationship with the Lord and confidence in hearing His voice, she struggled in the area of grinding it out in business (doing business primarily in her own strength). In this episode, she shares some of the keys to moving from grinding to being both led and empowered by the Holy Spirit in business. Pat has experienced the goodness, favor, and acceleration that takes place as you align yourself with God, choose to be courageous and follow His leading, and connect yourself with an authentic Kingdom business community. If you've struggled with working by God's grace rather than grinding, you may find yourself in some aspect of Pat's story, and hope you'll be encouraged by what she shared.
In our very first episode we sit down with Jack Simes, a 1968 World Track Championship Silver Medalist, Cycling Coach, Event Promoter and local Icon and discuss the past, present, and his view of the future of cycling. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/jorge-romero43/support
Literary Gardener host Rhonda Nowak talks with Rhianna Simes, co-director of Cultivate Oregon and co-founder of Verdant Phoenix, an urban mini-farm and educational center. Rhianna shares why she believes seeds are our future.
Frank Simes is a Grammy-nominated and platinum-record awarded musician, guitarist, songwriter, composer, and record producer. As The Who and Roger Daltrey's musical director and multi-instrumentalist, he has brought fresh elements to the sounds and arrangements for the world tours of Tommy, Quadrophenia, and The Who Hits 50!, as well as the 2012 Olympics performance. Frank recorded with Mick Jagger on the Wandering Spirit album, and was musical director for Stevie Nicks on her Enchanted tour. Having toured extensively and recorded with Don Henley as a guitarist and vocalist, he also co-wrote Workin' It and Goodbye to a River with Henley, and is featured as the band leader on the Inside Job DVD. Frank Simes has also recorded or performed with Rod Stewart, Don Felder, Charlotte Church, Mylène Farmer, Sylvie Vartan, Engelbert Humperdinck, David Lee Roth, Warren Zevon, Roger Waters, and Martha Davis. He recorded on Roger Daltrey's Moonlighting CD and DVD, is interviewed and performs on The Who's documentary An Amazing Journey and performs in The Who's Quadrophenia Live in London DVD. Frank has composed over 1,500 pieces of music for Paramount TV, Cord Worldwide, Los Angeles Post Music, Boyd Communications, and OPM Productions, including national TV commercials, and scores and cues for TV and film. He scored and sang lead vocals in a scene of Stephen King's film Cell, starring John Cusack and Samuel L. Jackson. Frank also composes original guitar and piano pieces in the contemporary, Modern, Baroque, and Romantic styles, which were recorded by the London Philharmonic Orchestra. Simes produced a version of Let My Love Open the Door for a Teenage Cancer America commercial with Roger Daltrey on vocals. Simes and partner, Lisa Verlo, composed and authored two musicals: The Door and Sex Rated G: A One Woman Show With A Man In It. Sex Rated G was produced and performed at the 2015 Edinburgh Fringe Festival in Scotland. Frank composed the music for Verlo's one-woman show HOLLYWOODN'T, which was nominated for the Larry Cornwall Award for Musical Excellence and received a Producer's Encore Award at Hollywood Fringe Festival 2019. Frank Simes wrote People Like To Rock, a jingle that was used for a Honda commercial for six consecutive years. Simes' current projects include writing a memoir, and developing a documentary and an immersive dome production based on his keynote talk entitled The Big Strum Theory, which makes a connection between music, science, and spirituality.Felipe has been touring in bands for over 15 years in the New York City area. He has performed around the USA, Europe, Japan, Australia, and Canada, as well as appearing on The CBS Morning Show, TV Land, The Biography Channel, The Modern Drummer Festival 2008 and has had his articles published on the Evans and Vic Firth websites. He has toured with OURS, The Monkees, and Chubby Checker, the Davy Jones Band, Reagan Youth, and Popa Chubby . He is also currently in original metal band ZIRE'S WAR fronted by Joey Z of Life Of Agony.As a session drummer, Felipe prides himself on his instincts as to what the music needs, for any style or performer. It's never about “Him.” That makes him an in demand musician, besides being easy to work with as a person.Teaching drums for the last 18 years has also led Felipe to start performing clinics around the country as well as produce his own online video series, Flip of the Week. He specializes in teaching from beginners to advanced players on drum set and orchestral percussion, reading, rudiments, and various styles of music. Felipe proudly endorses Evans Drumheads, DDrum Electronics, Amedia Cymbals,
Deux vainqueurs inattendus ont soulevé le trophée à Indian Wells ce week-end: Paola Badosa et Cameron Norrie. Tous les deux auteurs d'une saison 2021 sensationnelle, ils ont confirmé leur statut de révélations de l'année. Je vous les présenterai un peu plus en détail, pour ceux qui ne les connaissent pas. Mais qu'est-il arrivé à Daniil Medvedev, grand favori dans le désert californien? Et bien vous entendrez le Russe dans ce podcast.. Et puis, on évoquera évidemment aussi le 14ème titre en double de notre compatriote Elise Mertens.
☕ Con 28 locales en Córdoba y en Tucumán, Pizzería Popular busca cerrar el 2021 con 10 nuevas aperturas en el país y también en Uruguay. Para el 2022 sumarán a su agenda un puñado de aperturas internacionales (entre las que se destacan México y Miami). “Queremos ser la pizzería más grande de América Latina”, anhela Esteban Simes, fundador de la cadena, en esta mesa de café en Cardinales Cofico (GNI).
Dimitri Simes has been in the thick of United States-Russia relations for the past five decades. Born in Moscow, he arrived in Washington in the 1970s and never left. He has advised US Presidents Richard Nixon and Donald Trump, and met with Russian President Vladimir Putin. Simes says relations will not “reset” between the two countries unless they compromise on Ukraine, which both consider part of their “backyard”. Until then, they can only talk about cooperating on climate change and nuclear proliferation. Join host Steve Clemons in a wide-ranging interview with Simes, the CEO of the Center for the National Interest in Washington. - Subscribe to our channel: http://aje.io/AJSubscribe - Follow us on Twitter: https://twitter.com/AJEnglish - Find us on Facebook: https://www.facebook.com/aljazeera - Check our website: https://www.aljazeera.com/
Inside the Comedy Institute "Tom Simes" Ep 4 Tom Simes, owner and booker for the Stir Crazy Comedy Club in Glendale, AZ (Phoenix) gives us the truth about what it really takes to break a new club on the road. Like a lot of road clubs, Tom is a former comic who decided to open his own club. But his motivations were surprisingly different than most. And his creation is a near perfect comedy environment. Here he discusses the way we communicate with clubs and the way clubs communicate with each other. And how you can actually get booked on the road. Some of what I thought was true. Some was eye-opening to say the least. He tells us, · The best recommendation you can get · The best ways to get seen by the club · What to include in an email to the booker · What NOT to do when communicating with a club · What bookers discuss with each other And so much more. Enjoy!
Hear from the legendary Frank Simes!! Due to technical difficulties, this guest appearance was cut short, but Frank will be back for a part 2! Featuring music from: Dear Souls, Peter Cerman, Frank Simes and Jacob Ryan Birthday messages goin out to: Victor Piasecki, Jena Fesmire, JT Newberry and Daniel Webster Special announcement for Jessica Cook and Martin Grooms! --- Support this podcast: https://anchor.fm/phiresflames/support
In this episode, I talk to Mrs. Shaindel Simes. Shaindel and her family were in an accident that left her husband, Rabbi Yehuda Simes, A'H" a quadrapelegic. Shaindel's story is one of perseverance, faith, and a positive message for anyone going through hard times. Check out more at: www.maverickpodcasting.com --- Support this podcast: https://anchor.fm/yocheved-davidowitz/support
DJ/Artist/A&R Simes Carter out of Denver, Zoom calls us about his new endeavors, having the Rona last year, and how the COVID has made him pivot how he handles business. Also we get a surprise call from someone named "Gabe" who claims to be homophobic and racist. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/thebsshowpod/message
Pascal Obispo lance son application «Obispo all access» réunissant toutes ses musiques et des contenus inédits. Un moyen pour l'artiste de se libérer artistiquement des maisons de disques et des plateformes de streaming. Et si 2021 était son millésime, sa plus belle année ? Pascal Obispo sait que rien ne dure, qu’il peut mourir demain, il sait aussi qu’on n’est pas seul sur Terre. Alors, pour Lucie, pour Zinedine, pour Rosa, pour tous ces fans qui sont tombés pour lui, pour sa génération pour qui il est le chanteur idéal, le grand amour, plus que tout au monde, il vient de lancer «Obispo all access», une application sur smartphones, avec l’essentiel et superflu, secret perdu et magic trip. Pas besoin de regrets, l’important c’est d’aimer, le meilleur reste à venir. Et s’il avait trouvé sa raison d’être ? Pascal Obispo est avec notre invité. → Pascal Obispo sur RFI Musique En fin d'émission, la chronique musique d'Alain Pilot. Il a rencontré Aurore Voilqué Trio, chanteuse et talentueuse violoniste de jazz. Elle a invité Angelo Debarre, guitariste de renom, à rejoindre son trio pour enregistrer son nouvel album de jazz manouche «Un soir d'été».
Running a flight school is hard work. Doing it in Alaska is even harder. Doing it as a woman in Alaska? That’s practically unheard of. But Jamie Patterson-Simes isn’t just running a school in Alaska, she’s crushing it. Patterson-Simes is the owner of SkyTrek Alaska, AOPA’s Best Flight School of 2017. AOPA Hangar Talk co-host David Tulis sat down with Patterson-Simes to discuss what it’s like to run a school, working at Wal-Mart to support herself when she first started instructing, and the challenges of being a woman running a business in a man’s world. This conversation is part of the Flight Time series from Hangar Talk, where we revisit some of the most popular interviews for the Flight Training audience.
This Section describes the principal links between the Trump Campaign and individuals with ties to the Russian government, including some contacts with Campaign officials or associates that have been publicly reported to involve Russian contacts. The Office investigated whether those contacts constituted a third avenue of attempted Russian interference with or influence on the 2016 presidential election. In particular, the investigation examined whether these contacts involved or resulted in coordination or a conspiracy with the Trump Campaign and Russia, including with respect to Russia providing assistance to the Campaign in exchange for any sort of favorable treatment in the future. Based on the available information, the investigation did not establish such coordination. Each subsection begins with an overview of the Russian contact at issue and then describes in detail the relevant facts, which are generally presented in chronological order, beginning with the early months of the Campaign and extending through the post-election, transition period. This episode covers pages 66-173 of the "Report on the Investigation into Russian Interference in the 2016 Presidential Election." IV. Russian Government Links To and Contacts With The Trump Campaign (1:13) IV.A. Campaign Period (September 2015 – November 8, 2016) (2:27) Trump Tower Moscow Project (3:55) Trump Tower Moscow Venture with the Crocus Group (2013-2014) (5:04) Communications with I.C. Expert Investment Company and Giorgi Rtskhiladze (Summer and Fall 2015) (7:30) Letter of Intent and Contacts to Russian Government (October 2015-January 2016) (11:14) Discussions about Russia Travel by Michael Cohen or Candidate Trump (December 2015-June 2016) (22:11) Origins of Campaign Work (33:10) Initial Russia-Related Contacts (35:45) March 31 Foreign Policy Team Meeting (40:22) George Papadopoulos Learns That Russia Has "Dirt" in the Form of Clinton Emails (41:55) Russia-Related Communications With The Campaign (46:22) Trump Campaign Knowledge of "Dirt" (51:35) Additional George Papadopoulos Contact (53:33) George Papadopoulos (31:59) Background (57:16) Origins of and Early Campaign Work (1:00:22) Carter Page's July 2016 Trip To Moscow (1:02:17) Later Campaign Work and Removal from the Campaign (1:07:44) Carter Page (56:23) CNI and Dimitri Simes Connect with the Trump Campaign (1:10:57) National Interest Hosts a Foreign Policy Speech at the Mayflower Hotel (1:13:58) Jeff Sessions's Post-Speech Interactions with CNI (1:17:41) Jared Kushner's-Continuing Contacts with Simes (1:19:40) Dimitri Simes and the Center for the National Interest (1:09:51) Setting Up the June 9 Meeting (1:24:40) The Events of June 9, 2016 (1:32:59) Post-June 9 Events (1:38:21) June 9, 2016 Meeting at Trump Tower (1:22:31) Ambassador Kislyak's Encounters with Senator Sessions and J.D. Gordon the Week of the RNC (1:44:44) Change to Republican Party Platform (1:46:25) Events at the Republican National Convention (1:43:33) Ambassador Kislyak Invites J.D. Gordon to Breakfast at the Ambassador's Residence (1:51:40) Senator Sessions's September 2016 Meeting with Ambassador Kislyak (1:52:28) Post-Convention Contacts with Kislyak (1:51:17) Paul Manafort's Ties to Russia and Ukraine (1:59:02) Contacts during Paul Manafort's Time with the Trump Campaign (2:04:35) Post-Resignation Activities (2:17:33) Paul Manafort (1:55:05) IV.B. Post-Election and Transition-Period Contacts (2:23:57) Immediate Post-Election Activity (2:24:41) Outreach from the Russian Government (2:25:13) High-Level Encouragement of Contacts through Alternative Channels (2:26:56) Background (2:30:25) Kirill Dmitriev's Post-Election Contacts With the Incoming Administration (2:32:41) Erik Prince and Kirill Dmitriev Meet in the Seychelles (2:35:52) Kirill Dmitriev's Post-Election Contact with Rick Gerson Regarding U.S. Russia Relations (2:44:10) Kirill Dmitriev's Transition-Era Outreach to the Incoming Administration (2:29:12) Ambassador Kislyak's Meeting with Jared Kushner and Michael Flynn in Trump Tower Following the Election (2:49:32) Jared Kushner's Meeting with Sergey Gorkov (2:52:42) Petr Aven's Outreach Efforts to the Transition Team (2:57:13) Carter Page Contact with Deputy Prime Minister Arkady Dvorkovich (3:02:16) United Nations Vote on Israeli Settlements (3:05:03) U.S. Sanctions Against Russia (3:06:47) Contacts With and Through Michael T. Flynn (3:03:52) Mueller Report Audio - muellerreportaudio.com Presented by Timberlane Media - patreon.com/timberlanemedia Donate anonymously - glow.fm/insider Or donate with Crypto Music by Lee Rosevere
This Section describes the principal links between the Trump Campaign and individuals with ties to the Russian government, including some contacts with Campaign officials or associates that have been publicly reported to involve Russian contacts. The Office investigated whether those contacts constituted a third avenue of attempted Russian interference with or influence on the 2016 presidential election. In particular, the investigation examined whether these contacts involved or resulted in coordination or a conspiracy with the Trump Campaign and Russia, including with respect to Russia providing assistance to the Campaign in exchange for any sort of favorable treatment in the future. Based on the available information, the investigation did not establish such coordination. Each subsection begins with an overview of the Russian contact at issue and then describes in detail the relevant facts, which are generally presented in chronological order, beginning with the early months of the Campaign and extending through the post-election, transition period. This episode covers pages 66-173 of the "Report on the Investigation into Russian Interference in the 2016 Presidential Election." IV. Russian Government Links To and Contacts With The Trump Campaign (1:13) IV.A. Campaign Period (September 2015 – November 8, 2016) (2:27) Trump Tower Moscow Project (3:55) Trump Tower Moscow Venture with the Crocus Group (2013-2014) (5:04) Communications with I.C. Expert Investment Company and Giorgi Rtskhiladze (Summer and Fall 2015) (7:30) Letter of Intent and Contacts to Russian Government (October 2015-January 2016) (11:14) Discussions about Russia Travel by Michael Cohen or Candidate Trump (December 2015-June 2016) (22:11) Origins of Campaign Work (33:10) Initial Russia-Related Contacts (35:45) March 31 Foreign Policy Team Meeting (40:22) George Papadopoulos Learns That Russia Has "Dirt" in the Form of Clinton Emails (41:55) Russia-Related Communications With The Campaign (46:22) Trump Campaign Knowledge of "Dirt" (51:35) Additional George Papadopoulos Contact (53:33) George Papadopoulos (31:59) Background (57:16) Origins of and Early Campaign Work (1:00:22) Carter Page's July 2016 Trip To Moscow (1:02:17) Later Campaign Work and Removal from the Campaign (1:07:44) Carter Page (56:23) CNI and Dimitri Simes Connect with the Trump Campaign (1:10:57) National Interest Hosts a Foreign Policy Speech at the Mayflower Hotel (1:13:58) Jeff Sessions's Post-Speech Interactions with CNI (1:17:41) Jared Kushner's-Continuing Contacts with Simes (1:19:40) Dimitri Simes and the Center for the National Interest (1:09:51) Setting Up the June 9 Meeting (1:24:40) The Events of June 9, 2016 (1:32:59) Post-June 9 Events (1:38:21) June 9, 2016 Meeting at Trump Tower (1:22:31) Ambassador Kislyak's Encounters with Senator Sessions and J.D. Gordon the Week of the RNC (1:44:44) Change to Republican Party Platform (1:46:25) Events at the Republican National Convention (1:43:33) Ambassador Kislyak Invites J.D. Gordon to Breakfast at the Ambassador's Residence (1:51:40) Senator Sessions's September 2016 Meeting with Ambassador Kislyak (1:52:28) Post-Convention Contacts with Kislyak (1:51:17) Paul Manafort's Ties to Russia and Ukraine (1:59:02) Contacts during Paul Manafort's Time with the Trump Campaign (2:04:35) Post-Resignation Activities (2:17:33) Paul Manafort (1:55:05) IV.B. Post-Election and Transition-Period Contacts (2:23:57) Immediate Post-Election Activity (2:24:41) Outreach from the Russian Government (2:25:13) High-Level Encouragement of Contacts through Alternative Channels (2:26:56) Background (2:30:25) Kirill Dmitriev's Post-Election Contacts With the Incoming Administration (2:32:41) Erik Prince and Kirill Dmitriev Meet in the Seychelles (2:35:52) Kirill Dmitriev's Post-Election Contact with Rick Gerson Regarding U.S. Russia Relations (2:44:10) Kirill Dmitriev's Transition-Era Outreach to the Incoming Administration (2:29:12) Ambassador Kislyak's Meeting with Jared Kushner and Michael Flynn in Trump Tower Following the Election (2:49:32) Jared Kushner's Meeting with Sergey Gorkov (2:52:42) Petr Aven's Outreach Efforts to the Transition Team (2:57:13) Carter Page Contact with Deputy Prime Minister Arkady Dvorkovich (3:02:16) United Nations Vote on Israeli Settlements (3:05:03) U.S. Sanctions Against Russia (3:06:47) Contacts With and Through Michael T. Flynn (3:03:52) Mueller Report Audio - muellerreportaudio.com Presented by Timberlane Media - patreon.com/timberlanemedia Donate anonymously - glow.fm/insider Or donate with Crypto Music by Lee Rosevere
Please join us Right Now, September 28, 2020 at 11:00AM PST as Musician, Guitarist, Songwriter Frank Simes and Colorist Gareth Cook joins host Ron Brewington on "The Actor's Choice."
Producer/Artist/DJ Simes Carter calls in and chops it up with us about the industry and how he views the current state of Hip-Hop. Also women chime in on what sex toys work best for them! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/thebsshowpod/message
In recent years there has been a rise in lawsuits against the increasingly popular ridesharing companies, like Lyft and Uber. Ringler Radio host Larry Cohen along with co-host, Manny J. Valdez, Jr. and guest, attorney Laurel L. Simes, founding partner of Levin Simes Abrams LLP, talk about this growing legal topic, the rideshare companies' response to allegations and litigation, and what needs to be done to guarantee the safety of the passenger.Visit Ringler to contact a consultant in your area about structured settlements.
In recent years there has been a rise in lawsuits against the increasingly popular ridesharing companies, like Lyft and Uber. Ringler Radio host Larry Cohen along with co-host, Manny J. Valdez, Jr. and guest, attorney Laurel L. Simes, founding partner of Levin Simes Abrams LLP, talk about this growing legal topic, the rideshare companies’ response to allegations and litigation, and what needs to be done to guarantee the safety of the passenger. Visit Ringler to contact a consultant in your area about structured settlements.
In recent years there has been a rise in lawsuits against the increasingly popular ridesharing companies, like Lyft and Uber. Ringler Radio host Larry Cohen along with co-host, Manny J. Valdez, Jr. and guest, attorney Laurel L. Simes, founding partner of Levin Simes Abrams LLP, talk about this growing legal topic, the rideshare companies’ response to allegations and litigation, and what needs to be done to guarantee the safety of the passenger. Visit Ringler to contact a consultant in your area about structured settlements.
Claudio Opazo: Director del proyecto SIMES.
On today's episode, Seth and Kevin Harrington speak to Steve Simes , Founder of Bluefish, one of the top personal concierge services in the world, and an expert marketer within the luxury industry, Steve has been quoted in various publications & TV including the Wall Street Journal, Forbes, London’s Sunday Times, South China Morning Post and many more... About the art of making things happen, Steve Sims was the son of a brick mason. This laid the foundation, yes… pun intended…, for his insane work ethic. Steve paints this amazingly vivid picture in his new book Bluefishing: The Art of Making Things Happen, where he saw his dad, uncles, and cousins. His entire family tree down the line of ladders. In that moment he realized that he would eventually be the next one on the ladder for the rest of his life. That night, he quit. The second he was clear there was a different way to think, he took action. Ever since Steve has been pulling off the unimaginable. He’s been able to make his clients’ wildest dreams come true, from a wedding at the Vatican, to being serenaded by Andrea Bocelli, to powerful business introductions to moguls like Elon Musk. Steve is an entrepreneur in the truest sense of the word, Steve is well regarded within the luxury world for his innovation and down-to-earth personality. Known for his honesty, integrity and doing things “his way,” Steve creates experiences for his clients that they could never have imagined being possible. He makes the impossible, possible, after all he is quoted as “The Real Life Wizard of Oz" by Forbes and Entrepreneur Magazine More about Steve here, https://podcasts.apple.com/us/podcast/the-art-of-making-things-happen-bluefishing-steve-sims/id1429230476 Learn more about your ad choices. Visit megaphone.fm/adchoices
We have no idea what corrupted gear is all about so we’ve asked Simes to come and explain it to us! And a very good job he does to. You can find him on Twitter @sivation Next week: Shoeboots is … Continue reading →
Evelyn Farkas, former Deputy Assistant Secretary of Defense for Russia, and Dimitri Simes, CEO and President of The Center for the National Interest, join Christiane Amanpour to discuss the start of Trump's impeachment trial in the senate as the President readies himself for the World Economic Forum in Davos. Simes and Farkas dig down into U.S. relations with Russia and the rest of the world. Steve Inskeep, NPR host, discusses his new book "Imperfect Union," that tells the story of America's first political power couple, John and Jessie Fremont. In 1856 John was the first ever Republican nominee for president and the campaign was dominated by immigration, race, and political demagoguery. Inskeep reflects on the parallels with today's politics. Sarah Hurwitz, White House speechwriter for President Barack Obama and First Lady Michelle Obama, has turned her focus from politics to Judaism in her book "Here All Along." She sits down with Our Michel Martin to explain why she thinks the Jewish faith, that she was born into, can help us in these divisive times.
In this episode Ron talks with Tom Simes, Host of the Business of Comedy podcast and owner of Stir Crazy Comedy Club in the Arizona West Valley. Tom talks about what its like managing the podcast, the comedy club, being in Westgate, and advice for comics looking for stage time. Ron also mentions Stu Bakers quest to leverage bits from Ron's act.http://thebusinessofcomedy.libsyn.com/ https://stircrazycomedyclub.com/Tom also mentions the upcoming 2nd Annual Stand Up & Give Back show. 40 of Arizona's best stand up comedians come together for a week of laughter to give back to the community. Each show will have a different lineup of comedians. Proceeds from ticket sales will go to Jerry's Charities.Jerry's Charities was started by Glendale Mayor, Jerry Weiers in an effort to make positive difference in the lives of local citizens in need. For more information, go to https://jerryscharities.orgSupport the show
Make sure to catch a show at Stir Crazy Comedy Club (https://stircrazycomedyclub.com/) when you're in the Phoenix area and check out Tom Simes's new podcast "The Business of Comedy" here: https://podcasts.apple.com/us/podcast/id1481892658 Please Rate 5 Stars and Leave a Review it really does help! Go to TheDifferentBook.com to order copies of my new children's book "Different." www.thedifferentbook.com Follow me on social media if you want @GeoffKeith Email whatever you'd like to thegeoffkeithshow@gmail.com
In this Podcast I speak with Beth Simes about the current Sex Education in our Schools....
The Passion Behind Anastasia Simes’ Dramatic Jewelry Designs & How Her Frustration to Find the Perfect Gift Led to Her Jewelry Career Anastasia is as lovely and captivating as her jewelry! I found her background and story fascinating, and felt the dramatic aesthetic of her jewelry is a perfect fit for October! I’m so grateful for her taking the time with me to visit for both the podcast and in person in her studio, because she’s a VERY busy woman! For jewelry images and show notes to the show, be sure to find the blog post on jewelrynavigator.com Besides her jewelry projects, Anastasia’s most recent costume and set design can be seen in a unique presentation of Synetic Theater’s wordless interpretation of Shakespeare’s The Tempest on a stage of water! You have to see it to understand - so please see the links in bio for more, and if you’re in the DC area, and love dance and theater, consider attending one of the performances - through October 20. Synetic Theater is in Arlington, VA, and I’ll post links and show notes in the blogpost, which will publish soon. Thanks so much for joining me today for today’s Jewelry Navigator Podcast - I know you have a choice in podcast, and truly appreciate your support! We’re getting closer to 10,000 downloads of the podcast, and look forward to celebrating that milestone, so would you be sure to share Jewelry Navigator with your friends, family and co-workers who would enjoy listening as much as you do? And, if you’re a jeweler, jewelry designer, jewelry collector or fanatic, reach out to me on IG or through e-mail with questions, podcast topic suggestions, to be featured as a guest on Jewelry Navigator Podcast, or just to say hello! I love connecting with my listeners! Next week, I’ll be back with Kathleen Cutler, a Business Mentor for Fine & Antique Jewelers with more tips for designers and jewelry brands on how to reach their ideal clients, while focusing on catering to the consumer in and out of e-commerce. So, until next time, cross check your sparkle, and now that we’re approaching coat and sweater weather, get your ring prongs checked! Talk to you next time! bye bye!
This was now a fruitful podcast I had with Beth Simes. We as the homo-sapiens of planet earth really need to stop blaming Capitalism for the filth we create, its time we educate ourselves on how to recycle our waste/refuse. Links for reference: https://l.facebook.com/l.php?u=https%3A%2F%2Flinktr.ee%2Flife_out_of_the_fast_lane%3Ffbclid%3DIwAR1jOckWgKmaKO3ItJX3EvjEdMCMcoBUr7dFsa0fc2eoeCyK3hfKBgnpWSw&h=AT00NVpmxaJJyFAbOpY8_XRnXcy8cD713uBkhgzy4HlxfW_gxrXNZmg7m19pV53sA0I7wRWTvYiVS6ZtDsXYRx2ssxKDm9k4tc0tRT7EcvLtLh5W1tZJGlHs6HPHIfGJZQ Link: https://www.recycling.co.za/
Part 4 of 8 from Section IV: Russian Government Links To And Contacts With The Trump Campaign. This subsection of Volume 1, pages 103-110, outlines interactions with the Center for the National Interest, a D.C.-based non-profit with expertise in and connections to the Russian government. Dimitri Simes and the Center for the National Interest (0:11) CNI and Dimitri Simes Connect with the Trump Campaign (1:16) National Interest Hosts a Foreign Policy Speech at the Mayflower Hotel (4:13) Jeff Sessions's Post-Speech Interactions with CNI (7:51) Jared Kushner's-Continuing Contacts with Simes (9:48) Mueller Report Audio - muellerreportaudio.com Presented by Timberlane Media Support via PayPal: donate@timberlanemedia.com Donate with Crypto Music by Lee Rosevere
Frank talks about playing w Don Henley (on & off for 20 years), Mick Jagger, Roger Daltrey, The Who… growing up in Japan, moving to LA on his own (at age 14)... rebuilding his relationship with his dad… coming literally a few seconds short of intentionally driving off a cliff… singing “Hey Jude” while standing next to Ringo & Paul, opening up for Paul McCartney, vintage gear, being a survivor, LOADS more interesting stuff: Subscribe https://www.everyonelovesguitar.com/subscribe/ Facebook: https://www.facebook.com/EveryoneLovesGuitar/ Instagram: https://www.instagram.com/everyonelovesguitar/ Twitter: https://twitter.com/ELovesGuitar
Oliver takes us through his first trip kayaking over 2500 miles down the Mississippi River from the headwaters at Lake Itasca to the Gulf of Mexico. He talks about his journey going through the deep forests of Minnesota, encountering wild animals, and meeting interesting people along the way. On his second attempt to conquer the river he was trying to break the record. He talks about that experience and why he had to pull out early.Support the show (http://www.alphaomnia.com)
Dr Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. I'm the one you usually hear chatting about all the papers in your weekly issue, however I am so delighted to be handing over the mic this week to two beloved colleagues, and they are Dr Greg Hundley and Dr Vlad Zaha, who will be taking us through this week's very special issue centered around cardio-oncology. Here they are. Dr Greg Hundley: My name is Greg Hundley. I'm a professor at VCU Health Sciences in Richmond, Virginia. We also have Vlad Zaha, who is an assistant professor at University of Texas Southwestern in Dallas. Dr Vlad Zaha: Hello, everybody. Dr Greg Hundley: We're going to be talking about the field of cardio-oncology today. As we all know, there have been many advances in the treatment of cancer lately, such that cancer is now becoming in some regards almost a manageable disease or a chronic disease for many individuals. But unfortunately we're seeing the emergence of cardiovascular disease in many patients, so much so that for some cancers, for example breast cancer survivors, cardiovascular events have supplanted the occurrence of cancer-related morbidity and mortality overall. And so emerging today is this new field of cardio-oncology, which is really a bridging discipline between oncologists and cardiologists that have been focused almost on examining the relationship between chemotherapies, radiation therapies, newer targeted immunologic therapies on the development of cardiovascular events. We as cardiovascular medicine specialists often become involved and then we are consulted to see a patient that might be scheduled to receive a cardiotoxic therapy and what should we do. Maybe they've already received, they're in the middle of the therapy, and we're asked to provide guidance to help the patient move through that therapy successfully. We're examining survivors now, those that have gone on the therapy and are experiencing increased cardiovascular risk. And then finally, a new emerging field that examines the association of risk factors that seem to be common between cancer and cardiovascular disease. In this issue of Circulation there are theories, really a miniseries of manuscripts, that are at this interface between cardiovascular and oncologic science and medicine. Following a similar miniseries that we published in 2015, this new block of manuscripts looks on some of the risk factors and mechanisms that may be common between these disorders. We're going to start today and look at this particular issue and examine the original manuscripts, look at the letters, and then talk a little bit about the review articles. I will walk through some of the introduction and then Vlad Zaha, who is working in cardio-oncology at University of Texas Southwestern, will help interpret for us some of the results and the meaning. The first study, an original manuscript by Simes et. al that's a subanalysis of the lipid study, and that's the Long-Term Intervention with Pravastatin in Ischemic Disease. The study is going to examine the relationship between D-dimer and the future development of cardiovascular events, but also importantly, cancer-related events. Remember, D-dimer is the degradation product of cross-linked fibrin markers of hypercoagulation and thrombosis. We use this a lot in the emergency department as an identifier of those at risk when we're suspecting one of CVT, pulmonary emboli, etc. This particular study focused on individuals aged 31 to 75 years that had experienced previously a myocardial infarction. The patients were randomized to receive 40 mg of pravastatin versus a placebo and as part of the study they were followed for six years to identify cardiovascular events. But at the end of the study another examination, an extended review, was enabled so that the patients or participants could be followed for another ten more years and in addition to looking at cardiovascular events, they also looked at all-cause mortality and etiologies of that mortality and specifically cancer. Vlad, can you tell us a little bit about some of the results and what did D-dimer predict? Dr Vlad Zaha: D-dimer has been considered a rather non-specific product that was first introduced in clinical practice in the 1970s for diagnosis of venous thromboembolisms. It is really interesting in this study that the others identified D-dimer that it is an independent predictor of not only long-term risk of arterial and venous events but all-cause mortality, cardiovascular disease mortality, cancer incidents and mortality and non-cardiovascular disease and non-cancer morality. It raises interesting questions that are further explored in an editorial in the same issue about what is a low and what is a high D-dimer and also what drives the D-dimer generation in these patients. Dr Greg Hundley: And so, it's interesting as well that one is identifying those at risk of cardiovascular disease but also cancer. Do the authors and the editorialists speculate on what that connection may be? Dr Vlad Zaha: The question that is discussed is a common area of etiology that is being more and more discussed nowadays as bridging the domains of heart disease and cancer, and that is information. Information resulting then in alteration of the clotting cascade and hypercoagulability that may then influence downstream both atherosclerosis and cancer processes. Dr Greg Hundley: Very good. It's interesting that we're bringing up this whole area of thrombosis because that really follows in the next study, which is a large population cohort assessment that is collected from a Danish registry of 6600 subjects that had experienced a lower extremity arterial, not venous, but arterial thrombosis. In that study what did they uncover, Vlad, in terms of an association with cancer and previously experiencing a lower extremity arterial thrombosis? Dr Vlad Zaha: Another interesting study where the patients uncovered an increased risk of cancer compared to the general population, especially during the first six months before, the investigators identified an association between lower limb arterial thrombosis and increased all-cause mortality in common especially for the smoking-related cancers. This is a very interesting study that brings up the possibility of opportunistic screening, again focused on cancer-related signs and symptoms during the diagnostic workup for lower limb arterial thrombosis. Dr Greg Hundley: And so, in these first two studies, both large in number, were identifying issues related to thromboembolic events and cardiovascular disease that also appear related or associated with the future development of cancer. The next couple of studies now switch and address issues related to mechanism. The first is a relatively large complex translational study by Meijers and associates that were examining the relationships between heart and vascular injury and the future development of colon cancer. In this particular study there were two separate experiments, one group performed in mice and the other performed in analyses of serum and plasma that were collected from human subjects that had experienced colon cancer. In the first series of experiments in mice, the mice were induced myocardial infarction and then they were a strain that were somewhat predisposed to development of colon cancer. What the investigators did is they examined in this strain predisposed to the development of colon cancer, the impact of inducing a myocardial infarction and promoting heart failure versus those that were not and they identified what looks to be some sort of association between an increased risk of development of colon cancer. Vlad, what were your observations and thoughts in terms of these particular findings and results? Dr Vlad Zaha: This is an interesting paradigm of bringing basic science observations and testing them in a translational fashion. It is a combination of really elegant studies in a mouse model that identifies potential targets of clinical relevance in a model of myocardial infarction. The authors evaluate the fact that such molecules in human cell line models and test the proliferation in that environment. The question is then: How does this reflect in a cohort of patients? That, I think, is really the strength of the study to be able to show that some of the biomarkers identified which events can have an implication at the bedside. Dr Greg Hundley: It was really interesting in that in the animals, independent of the hemodynamic compromise, so the hypotension, the reductions in EF, these circulating biomarkers that you identified seemed more associated with the development of colon cancer and then in the human study, examining similar factors were observed in patients with colon cancer and heart failure from the circulating blood of those individuals. Very interesting relationship identified in a very elegant translational study that involved both animal models and human subjects. The second mechanistic paper is by Li and associates and it's really addressing the issue of anthracycline-related cardiovascular injury. Remember, we still utilize anthracycline chemotherapy today as a fundamental curative component of the therapeutic regimen for lymphoma, leukemia and sarcoma, also in those with triple-negative breast cancer as an important component of that regimen for adjuvant treatment. In this particular study, the investigators were examining the implication of phosphoinositide 3-kinase. That is an important enzymatic regulator of tumorigenesis, but it also when it's expressed is up-regulated during cardiac stress and really impacts adverse remodeling and promotion of heart failure. In this particular study, the investigators in a mouse model were looking at blocking this particular enzyme and they had some really interesting results pertaining to the development of heart failure and cancer. Vlad, what did you see in this study that looked unique in that perspective? Dr Vlad Zaha: This is an especially interesting study for the perspective of the oncologists who still have to prescribe anthracycline, given the uncertainty of early toxicity that can manifest in some studies in five to ten percent of patients. Also, related to the late toxicity of anthracycline treatment in survivors of childhood cancer. What is particularly interesting about this isoform of phosphoinositide 3-kinase, the gamma isoforms, is that at the same time blocking this enzyme in macrophages increases the anti-tumor, I think it's the anthracycline therapy, and blocking it in the cardiomyocytes, suggests a potential cardioprotective mechanism. Having a target that can be used both to enhance the anti-cancer effect of anthracycline and to enhance the cardioprotective mechanism is really a potential ideal intervention that would help maximize the anti-cancer treatment and at the same time protect the heart. Dr Greg Hundley: Fantastic. Again, new research helping to come up with ways for those that continue to need anthracycline therapy that we may be able to attenuate some of the untoward cardiovascular effects, all the while preserving the antagonistic features associated with the treatment for cancer. Let's switch to the other sort of prospective original research format that we have in Circulation, and that's our letter format. Remember, our letters are addressing a specific point that can be readily appreciated in 800 words or less. The first is a letter by Anquetil et al that examines individuals recorded in the VigiBase World Health Organization database. This is basically a database organized around treatment of cancer and cancer therapeutics and it is examining those individuals that received sort of a newer class of agents called immune checkpoint inhibitors. Remember, that is modulation of our immune system to help attack cancer. In some rare circumstances, relatively infrequent, when these agents have been administered, the immune system has been unlocked and attacks the heart, promoting a myocarditis that if not recognized can be fulminant and lead to death. This particular group identified a new phenomenon that we need to be aware of and that's just frank myositis. Vlad, what are your thoughts on now perhaps these agents being associated with the development of myositis in the skeletal muscle? Dr Vlad Zaha: Often when adverse events, as you mentioned Greg, are an important concern for these new powerful tools for the oncologists and it has been pretty early in the process where some of the cases have demonstrated severe cardiovascular events. Fortunately it is a very low percentage, less than 1% of cases that can manifest with fulminant myocarditis, but this raises again a question of expanding the view towards other systems when we are applying one of these early novel molecular interventions. In this context, the recognition of myositis in another small percentage of patients is an important observation and increasing awareness of both cardiologists and oncologists towards this side effect is important as not all fatigue is equal and sometimes that can be due to manifestations of cardiomyopathy and sometimes it can be a manifestation of oxygen extraction in the peripheral tissue than muscle contractility. It is an important hypothesis-generating piece that will allow people to appreciate more of the complexity of addressing the intrinsic molecular mechanisms in cancer and heart disease. Dr Greg Hundley: It sounds that we need to be aware of another potential etiology of fatigue to put in an armamentarium of differential diagnoses for those patients that are not getting quite back to where they were from an exercise and activity level after treatment. The second research letter focuses on individuals that are receiving a Fontan procedure. Remember, Fontan procedures are surgical corrections for those primarily with single ventricles where we're diverting caval blood to the pulmonary circulation, since in some situations there's really no functional right ventricle. These patients over time experience chronic venous hypertension and have associations with liver disease. In this particular research letter, the authors are examining the relationship between really for the first report in an aggregate form of the relationship between undergoing a Fontan procedure and the development of hepatocellular carcinoma. Vlad, any quick comments to highlight on this particular procedure? I thought something that was interesting is that these individuals experienced these hepatocellular carcinomas in their 20s and 30s. Dr Vlad Zaha: That's right, Greg. This study confirms observations from previous case reports and the early occurrence of hepatocellular carcinoma is raising still important hypotheses for future clinical trials. On one hand, either there is an increased risk of hepatocellular carcinoma development in patients with non-cirrhotic livers after a Fontan operation, or the current screening modalities using imaging are insufficiently sensitive to identify early signs of cirrhosis in such patients and this stratifies them effectively at an early stage in their disease post-op Fontan procedure. Dr Greg Hundley: Lastly, let's just briefly discuss here, Vlad, some of the other editorials and review article formats that we have in Circulation. A particular one, a perspective that was written by Peter Libby and Ebert and associates that highlights this phenomenon potentially implicating inflammation and the link between cancer and atherosclerotic cardiovascular disease. The topic of this perspective is really on something called CHIP, which stands for clonal hematopoiesis of indeterminate potential. What is this CHIP? As we age, basically what happens is we accumulate mutations of hematopoiesis stem cells in our bone marrow. Over time these little clones, they actually have within our bone marrow some survival advantages and they can spill out into the blood and actually can be associated with future leukemias. Those that have a large population of this particular clonal progeny, these CHIP-type cells, they have an increased risk of developing cancer, but also the levels of these are associated with increased overall mortality and it appears some risk of cardiovascular disease. How could that be? One characteristic of this particular cell line is they are associated with dysregulation of inflammatory genes that go on to produce, are associated with other inflammatory mediators. Vlad, this is calling in question and helping us to examine the relationship between inflammation, cancer and cardiovascular disease. What are your thoughts here about these very important insights provided by Libby and Ebert? Dr Vlad Zaha: This is a fascinating perspective, Greg. It really brings, again, in the offline novel molecular mechanisms that have been discovered recently and that are becoming a turning point into the molecular interventions, not only in cancer but potentially soon in cardiovascular disease prevention and treatment. Having a common root for a problem set involving such a prevalent cardiovascular problem as atherosclerosis and cancers reveals the connection between the different systems and the fact that integrating our understanding of the molecular regulation of cell proliferation results in an effective translation of leading to new targets and new approaches to treat disease. It is striking that there are multiple areas where cancer and inflammation are interacting, one of them being at the cellular level and other ones at humoral levels, in a way reproducing other complex mechanisms that we see in regulation of inter-system interactions within the body. Dr Greg Hundley: And so, summarizing this entire issue in Circulation, what a wonderful collection of a series of original manuscripts, both in the extended and the letter format as well as review articles, including a primer by Handy and associates that evaluates or draws attention to our screening tools that how we might examine the relationship between cardiology and the whole world or hematologic oncology related issues. And then this very unique perspective by Peter Libby and really is a continuation of the growth of this, as we called earlier, the bridging discipline of cardiovascular medicine and oncology as we work toward improving survivorship of all individuals with cardiovascular disease and cancer. I want to thank you for the opportunity to be with you today and encourage you to follow these issues further with the journal. I'll turn this over to Vlad for any closing remarks. Dr Vlad Zaha: Thank you, Greg. This has been a really exciting overview of important points that are emerging now at this nexus between cardiology and oncology that give us a broader view of the complex interactions that the future will materialize for us, emerging from a molecular intervention on cancer, heart disease, immunologic disease and probably metabolic endocrinology disease. Thank you for listening. Dr Carolyn Lam: Thank you so much, Vlad and Greg. This is a tremendous issue and I'm sure, audience, you will be reaching for it right now, I would. Please let all your colleagues know about this podcast and tune in again next week.
In our inaugural episode, Sydney Catalyst Program Coordinator Ellen Brodie, sat down with Professors John Simes and Michael Boyer to chat about Sydney Catalyst and the change of Director.
Great talk about Snapchat with broker owner Joel Simes from Simes City Realty! To learn more about Joel, visit www.simescity.com
This week Mr B, EJ’s wonderful husbandface, joined us to tell us how raiding had been this time time round. Which is good ‘cos we haven’t really done much! You can find Simes @sivation on Twitter Next week: Reea will … Continue reading →
This week we talk to Jamie Patterson-Simes, owner of SkyTrek Alaska Flight Training, AOPA's flight school of the year. Hear about her incredible journey and dedication to bringing up the next generation of aviators. Plus stick around for the headlines.
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WEEK IN GEEK: In a fit of nostalgia, Andrew picks up The Sims 3 again (starts at 1:49) while Dan can't get past a nit-pick to enjoy anything Netflix's Castlevania has to offer (20:46). SDCC 2017: (34:04) It was a big weekend for nerd culture as the San Diego Comic Con dropped a bunch of new trailers on the world. Dan and Andrew look at three trailers and how they seem to be pointing out the creative direction of their respective studios with Marvel's Thor: Ragnarok, DC/Warner Bros.' Justice League, and Steven Spielberg's Ready Player One. RELATED EPISODES: Episode 29 - "Guitar Mode": Andrew discusses reading the Ernest Cline novel, Ready Player One. Episode 42 - "Unology": Dan and Andrew discuss the announcement that Steven Spielberg would be adapting Ready Player One as a film. WORKS CITED, REFERENCED, OR CONSULTED: Purdom, Clayton. “The Ready Player One Backlash Has Begun.” A.V. Club. Onion Inc., 24 July 2017. LINKS: Visit our website at forallintents.net and leave your thoughts as comments on the page for this episode. Join our Facebook page E-mail: Andrew - andrew@forallintents.net, D. Bethel - dbethel@forallintents.net Subscribe to our YouTube channel. Subscribe to and review the show on the iTunes store. For all intents and purposes, that was an episode recap. FEATURED MUSIC: -"Stayin' in Black" by Wax Audio
This week birthday boy Simes joined us to talk about the state of raiding in Legion. Sounds like we don’t like very much! You can find Simes on Twitter @sivation Next week: Marie is back! And we’re talking about titles … Continue reading →
On this episode of DLEW, I talk with Audrey Simes about integrating art forms. Sometimes, the best way to reach your audience is to use more than one discipline of art. Audrey shares her unique experiences working with different art forms, and how YOU can create an integrated work of art. Dance Like Everyone’s Watching with Andrea Muhlbauer is the show that brings you inspiration and insight into the world of dance and choreography. Andrea and her amazing guests are saying the things that no one else will. D.L.E.W. will tackle the MAJOR problems facing dance and the arts: the diminishing of audiences, the rise of new technologies, and the loss of artistic purpose. Slightly controversial opinions and real talk are guaranteed.
For more than a year I’ve been obsessed with Cincinnati, Ohio. While doing research on old churches being retrofitted as brewpubs, I stumbled across Taft’s Ale House in Cincinnati’s Over the Rhine neighborhood. From there, I went deep. The architecture. The flight to the suburbs. The abandonment. The subway that was built in the 20s but was never used. Then, new life. The comeback. To find out more about Cincinnati, I spoke with Randy Simes, an award-winning urban planner who founded a site called UrbanCincy back in 2007. Simes grew up on Cincinnati’s west side, and graduated from the University of Cincinnati’s nationally acclaimed School of Planning. He’s put together a team of writers and reporters that have elevated the conversation about urban planning, placemaking, and what’s making Cincinnati move on up. My obsession grows. Enjoy the show!
Pour bien choisir votre vin en fonction de son millésime, il y a quelques trucs à connaître que je vous donne ici, dans ce nouvel épisode. Je vous redonne également le tableau des millésimes de ces 45 dernières années, car plusieurs d'entre vous me l'ont demandé. Voici le lien pour le télécharger : http://www.le-vin-pas-a-pas.com/comment-sy-retrouver-dans-les-millesimes-de-vins
Jamie has been living and flying in Alaska since 1995. She owns SkyTrek Alaska Flight Training at Merrill Field, and teaches intrepid students how to fly. When not living and breathing aviation—and scrubbing the grease out from underneath her fingernails—she likes to spend time with her very tolerant husband and two teenage daughters. She’s famous for trying out her tofu recipes on her family and friends, and finding the leftovers in house plants. She’s honored to be chosen to tell another story.
Rachel Quednau interviews Randy Simes all the way from Seoul, South Korea, to talk about the Ohio Department of Transportation's expected announcement of a major shift toward “fix it first” policy, and away from new road projects. Randy is the founder and managing editor of UrbanCincy, news sources for Cincinnati's urban core, as well as an urban planner who has worked around the world.
Bob strolls through Manhattan and has a chat in Central Park with The Who's musical director, Frank Simes.
This week the ever lovely Simes joins us to talk all things mount collecting, and with 277 of his own he certainly knows what he’s talking about! Find out what are everyones favourites, and what we’re all working at in … Continue reading →
There are so many changes to gear and stats announced that we could only have one person to discuss that with us: Simes aka Husbandface J Show 119: Welcome Simes Interview time: quick recap time How was our week in … Continue reading →
Jaime is a recent MBA graduate and teaches intrepid students how to fly planes at UAA. When she is not hanging out with her very tolerant husband and two daughters, she ferries planes to Miami (for Bolivians who pay cash), walks on the mudflats to Fire Island, swims across Little Campbell Lake, mountain bikes, cross-country skis and volunteers as an usher at the PAC. She does not own a TV, but avidly listens to NPR while trying out new tofu recipes.
Add-ons, add-ons and more add-ons will be dominating this show. We are joined by EJ’s other half Simes and we talk about evil bunnies who try to steal our eggs! Show 48: Welcome back Si Interview time Quick recap about … Continue reading →
We want to thank Simes for providing us with all the prizes for this fantastic contest. So there will be one main prize and two runner up prizes. First Prime Signed copy of the Cybertronian Times featuring autographs from Simon Furman, Andrew Wildman, Lee Sullivan and Wally Wingert. Also signed autographed postcard from David Kaye and Dan Gilvezan The two runners up will receive signed post card from David Kaye and Dan Gilvezan So the question Which guest has appeared at Auto Assembly more times than any other including this year? Know the answer? Then email your answer along with your booking number to moonbase2cast@googlemail.com
We want to thank Simes for providing us with all the prizes for this fantastic contest. So there will be one main prize and two runner up prizes. First Prime Signed copy of the Cybertronian Times featuring autographs from Simon Furman, Andrew Wildman, Lee Sullivan and Wally Wingert. Also signed autographed postcard from David Kaye and Dan Gilvezan The two runners up will receive signed post card from David Kaye and Dan Gilvezan So the question Which guest has appeared at Auto Assembly more times than any other including this year? Know the answer? Then email your answer along with your booking number to moonbase2cast@googlemail.com
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