Podcasts about p5p

Previously shared as a paid newsletter in May 2024. In previous newsletters, I've addressed many of the more common contributing factors to brain symptoms, including high pyrroles, copper-zinc imbalances, methylation imbalances, candida overgrowth, mast cell activation, mold and other forms of toxicity, and genetic variants, such as COMT and MAOA.Supplements can be needed to address each of these. Medication can also be necessary when treating mold and mast cell activation.But what happens when someone can't tolerate a supplement or medication because it worsens or creates new brain symptoms? Why, for example, could someone have problems tolerating B6 or SAMe or Methionine. Why might someone have problems with folate, niacinamide, glutathione, certain herbal treatments, antidepressants such as SSRIs, probiotics, antifungal medication or binders such as bentonite clay, activated charcoal, chlorella or cholestyramine?In this newsletter, I'll discuss:* Five common reasons a supplement or medication may worsen symptoms.* Specific supplements and medications that are more likely to do this.* How reactions may point to root causes.* Treatment steps that can improve tolerance.There can be a wide range of brain symptoms that can occur when someone is having an adverse reaction, such as fatigue, brain fog, depression, anxiety, agitation, and even psychosis or mania. I'll use “reactivity” to refer to this range of possibilities. While physical side effects can also occur, the focus here will be on brain symptoms.5 Common Reasons Supplements or Meds May Worsen Symptoms1. Immune ReactivityOur immune system is intertwined with our central nervous system. When our body's immune system reacts to a toxin, microbe, injury, or trauma, we can have inflammatory brain and physical symptoms.“Feel Like I'm Reacting to Everything” - Mast Cell ActivationIf someone is experiencing severe immune reactivity, such as mast cell activation, they may react to many supplements and medications, as well as triggers in their environment and stress. The number of triggers can help point to an exaggerated immune response. In my practice, this high immune reactivity is usually driven by mold toxicity.For many with this obstacle, starting very low and slow can prevent reactions. For others, interventions may be needed to lower immune reactivity and stabilize mast cells. This, however, can require certain supplements. For those who can't tolerate those treatments, limbic system retraining programs help calm the immune system so people can move forward more easily.Sensitivity & IntoleranceIt is possible to have immune sensitivity (or even allergy) to a supplement, though I find this less common. Herbal supplements, for example, which are high in salicylates, may cause symptoms in those with salicylate sensitivity. Certain probiotics have bacterial strains high in histamine. This is an issue for those with histamine intolerance.2. Too Much or Too Little Neurotransmitter ActivitySome people with brain symptoms have high neurotransmitter (NT) activity, and some have low. Common NT's include serotonin (5-HT), dopamine (DA), and norepinephrine (NE). I use the term “neurotransmitter activity” because it's not just about the amount of neurotransmitters present; it's also about the amount of receptors present that pick up NTs and remove them from the space between nerve cells.High Neurotransmitter ActivityToo much neurotransmitter activity can cause brain symptoms such as mania, psychosis, agitation, anxiety, panic, obsessions, compulsions, and hyperactivity. Reactions can occur if supplements or medications are given that further increase NT activity.Examples include:* Overmethylation* Slow COMT (involved in clearing DA and NE) and/or slow MAOA (involved in clearing 5HT, DA and NE)A variant on COMT and/or MAOA doesn't mean they are being expressed.What Increases Neurotransmitters?* SSRIs (Selective Serotonin Reuptake Inhibitor) increase serotonin activity* SNRIs (Serotonin and Norepinephrine Reuptake inhibitors) increase serotonin and norepinephrine activity.* Stimulant medications such as Ritalin and Adderall increase dopamine activity* SAMe and methionine increase serotonin and dopamine activityRemember that there can be times when there is a mixed picture, such as when someone is undermethylated and has a slow COMT.Low Neurotransmitter ActivityReactions can occur if supplements or medication decrease the neurotransmitter activity when it is already low. This could look like depression, apathy, fatigue, and brain fog.Examples include:* Undermethylation* Fast COMT (involved in clearing DA and NE) and/or fast MAOA (involved in clearing 5HT, DA and NE). The NTs are getting cleared too fast.What Decreases Neurotransmitters?* Folate, a nutrient that is good for a lot of people happens to be a big problem for many with psychiatric conditions. Most with underemethylation have low serotonin symptoms (depression and/or anxiety). While folate can help methylation, as an unfortunate aside, it can also further lower serotonin activity. Folate is in most multivitamins and B Complex vitamins. To learn more: Undermethylation, MTHFR & The Great Folate Debate.* Niacinamide can lowers DA and NE.Looking closely at someone's symptoms and traits and assessing methylation through bloodwork can help determine if NTs are too high, low, or mixed and what types of treatment to consider.3. Poor Detoxification or Toxic OverloadZincZinc is one of the most powerful tools I use in my work. Some people can easily tolerate it, while others can struggle. Here are some reasons someone may not tolerate zinc.* High copper—Zinc mobilizes copper. Moving too much copper at once can increase copper symptoms (anxiety, anger, hyperactivity, insomnia).* High toxicity—Zinc is a strong antioxidant. It is needed for the genetic expression of one of the most important antioxidants in our body, metallothionein.It took me 8 months to get my dose up to an optimal range, which is certainly not the norm. I unknowingly had significant mold toxicity at the time.When I start someone on zinc, I slowly build it up over 3-4 weeks. For some (like myself), even this is too fast.GlutathioneThis is the other major antioxidant. If someone is having difficulty tolerating it, they may have problems with detoxification and significant toxicity (metals, biotoxins like mold, and chemicals). These can start to be addressed in several other ways.BindersThese include bentonite clay, chlorella, activated charcoal, and cholestyramine. They bind toxins, especially mold toxins, in the GI tract. If they are started too quickly, the toxins they are supposed to remove get stirred up, which stirs up symptoms. When people say they can't tolerate certain binders, they usually weren't started low enough.There are others, but these are the most common in my experience.4. Underlying Microbial or Microbiome IssueB6B6 is very important for brain health. It is needed for making serotonin, dopamine, and GABA. We use it in all the Walsh nutrient protocols to varying degrees. In the last 10 years, we've seen a decrease in B6 tolerance. It's not clear why. I'm including it in this section because the reactivity is suspected to be related to the microbiome. Perhaps in recent years, we have had collective damage to our microbiomes from toxins and rising EMF exposure. We don't know.The good news is that P5P, the active form of B6, is usually well tolerated. In my practice, I rely heavily on P5P. I will occasionally use it in combination with B6 (if tolerated) for those with especially high pyrroles.Methionine and/or SAMeBoth are used, though usually not together, to help address undermethylation. I suspect candida or mold when someone is having difficulties tolerating either of these. These nutrients are usually better tolerated once candida and/or mold are addressed (or are starting to get addressed).5. Die-OffAnything that kills off microbes, such as candida or mold, can cause a “die off” of those microbes, release toxins, and worsen symptoms. Antifungal supplements, antifungal medication, and probiotics may cause this type of reactivity. Antifungal medications include nystatin, diflucan, itraconazole, and amphotericin B.Herbs and food-based supplements can have antimicrobial effects. Turmeric is one example. There are many others, so it's always worth checking. Worsening symptoms might point to an underlying fungal or other microbial overgrowth. It may also suggest that appropriate binders may be needed first.Addressing or preventing die-offs could mean supporting detoxification, starting binders if necessary, and, again, starting low and going slow.Antidepressants, interestingly, have been shown in labs to have antifungal effects. This does make me wonder if some people who can't tolerate them are having die-off.Root CausesKnowing someone's history of reactions can help point to underlying root causes.As you can see, there are typically ways to help someone tolerate and go on to benefit from a needed supplement or medication.As always, I welcome your thoughts and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Injectable Yohimbine dosing, What does high dose T3 look like? Maltodextrin Intraworkout? Side to look out for on 1000mg Test Cycle TIME STAMPS BELOW - DNS Podcast Dave Crosland & Scott McNally

Discover simple and effective methylation support strategies to boost your health, energy, and vitality.Methylation defects refer to genetic or biochemical issues that disrupt the body's ability to properly carry out the methylation process, which is essential for detoxification, DNA repair, neurotransmitter production, and overall cellular health. A common cause of methylation defects is mutations in the MTHFR gene, which can impair the body's ability to process folate and produce methyl groups. This can lead to a variety of health issues, including fatigue, cognitive problems, mood disorders, and an increased risk of chronic diseases.**Treating Methylation Defects**  Treatment for methylation defects often involves supporting the body's ability to methylate through dietary and lifestyle changes. Key strategies include:1. **Folate**: Ensure you're getting enough bioavailable forms of folate, such as L-methylfolate, which is easier for those with MTHFR mutations to absorb and utilize.2. **Vitamin B12**: Methylcobalamin is the preferred form of B12 for methylation support, as it directly contributes to the methylation cycle.3. **Vitamin B6**: Pyridoxal-5-phosphate (P5P) is the active form of B6, which helps in the conversion of homocysteine to cysteine, a process crucial for detoxification.4. **Betaine (Trimethylglycine)**: This supplement can help support methylation by donating methyl groups to the body, particularly for those who have difficulty utilizing folate and B12.5. **SAMe (S-Adenosyl Methionine)**: SAMe is a direct methyl donor that can help support mood, detoxification, and liver function.6. **Antioxidants**: Supplements like vitamin C, E, and glutathione may help protect cells from oxidative stress due to impaired methylation.7. **Magnesium**: Supports enzyme function and relaxation, helping to reduce the stress that can exacerbate methylation problems.**Diet and Lifestyle**  A diet rich in whole foods, including leafy greens (for folate), healthy fats, and lean proteins, can help optimize methylation. Avoiding toxins, reducing stress, and getting adequate sleep are also key factors in supporting methylation health. Consulting with a healthcare provider or functional medicine practitioner is advised to tailor supplementation and dietary changes based on individual needs.Check out my facebook page for health coaching/consulting: https://www.facebook.com/sagehealthcoachingIn this episode, I share practical tips and resources, including supplements and books that have helped me on my journey.Whether you're looking to optimize your well-being or gain insight into nutritional genetics, there's something here for you.Resources mentioned in the episode:Horbäach Creatine Monohydrate PowderA vegetarian, non-GMO, gluten-free supplement perfect for energy and muscle support.Buy on AmazonSeeking Health Multivitamin One MFMTHFR support with folinic acid and vitamin B12 in a methyl-free, easy-to-digest formula.Buy on AmazonDirty Genes by Dr. Ben LynchA revolutionary guide to health and wellness through nutritional genetics and personalized plans.Buy on AmazonSeeking Health Optimal PCBrain and liver support with sunflower lecithin for optimal energy and function.Buy on AmazonSeeking Health B Complex PlusA vitamin B complex supplement designed to support brain health, digestion, and energy.Buy on AmazonContact & Additional Resources:

Today, we are exploring the benefits of Vitamin B6.Vitamin B6 is an essential nutrient for horses and humans, and I use it regularly for various purposes. In this episode, I explain how it functions in the body, the signs and causes of a Vitamin B6 deficiency, and how to use it effectively.Nutrient Deficiency and Therapeutic Use of B6 in HorsesVitamin B6 gets used for its therapeutic properties in horses, even without a confirmed deficiency. Many horses are likely deficient in Vitamin B6, especially those on hay diets without access to fresh forage.Regulatory Minimums in Horse FeedsIn Canada, the CFIA mandates minimum levels of fat-soluble vitamins (A, D, E) in horse feeds, but B vitamins like B6 are often left out. That can lead to deficiencies, as the commercial feeds might not always meet the nutrient requirements of some horses.Digestive and Absorption ChallengesMany horses struggle to absorb nutrients from their feed, especially those with digestive issues like ulcers, colic, or diarrhea. Even when given sufficient food, compromised digestion can reduce the effectiveness and compound nutritional deficiencies over time.Role of B6 in Metabolism and HealthVitamin B6 is essential for carbohydrate, protein, and fat metabolism, so it is critical for horses with metabolic conditions like insulin resistance. Vitamin B6 also supports magnesium and Vitamin B12 absorption and helps to address those nutrient deficiencies.B6 for Skin, Immunity, and InflammationVitamin B6 helps with conditions like itchy, flaky skin and hives in horses. It also improves immune health by regulating inflammation and fluid retention, making it particularly useful for horses with metabolic issues.Neurological and Behavioral BenefitsVitamin B6 is involved in neurotransmitter production, like serotonin and melatonin, which affect brain health and mood regulation. Horses with anxiety, depression, or behavioral issues may benefit from Vitamin B6 supplementation, as it helps balance the nervous system.Hormonal Imbalance and Liver SupportVitamin B6 helps regulate estrogen, making it useful for mares with hormonal issues or insulin-resistant horses with liver stress. It supports liver detoxification, which is crucial for horses with a high toxic load due to poor diet or metabolic conditions.Sources of B6Vitamin B6 is in flax and wheat germ, but it is hard to determine the exact amount in horse feed. As such, targeted Vitamin B6 supplementation is often necessary to meet their needs.Signs of Vitamin B6 DeficiencyDeficiency symptoms include hormonal imbalances, weight gain, joint inflammation (often misdiagnosed as arthritis), skin problems, depression, and anxiety. So, horses with these symptoms tend to improve with Vitamin B6 supplementation.Proper Dosage and FormsThe recommended Vitamin B6 dose for horses is around 750 mg of B6 daily, with up to 1000 mg for a loading dose. The pyridoxine form of B6 is commonly used for horses, while the P5P form is more bioavailable for humans.ConclusionVitamin B6 offers significant benefits, from supporting metabolic health to improving behavioral issues and reducing inflammation. If you are trying Vitamin B6 for your horse, pay attention to any health or mood changes and adjust the dosage as needed.Links and resources:Connect with Elisha Edwards on her website Join my email list to be notified about new podcast releases and upcoming webinars.Free Webinar Masterclass: Four Steps to Solving Equine Metabolic...

The transparent, opinionated Marco returns as we talk about youth on steroids and an update to his health and protocolWe also expound on the last podcast, including relationships, mental health, and some things that weren't mentioned. The contrast between Marco's normal state and my prep state is crazy. Always appreciate Marco for opening upPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Watch The Podcast:https://www.youtube.com/channel/UCqgN2kieCEHwZ9M-QFBxfCgPharma TRT, GH analogs, peptides, IGF-1, var troche, fat-loss/hair-loss treatments, etc | HRT Men's Health Optimization: https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaHuge Elements Line (astragalus, citrus bergamot, etc): https://hugesupplements.com/collections/elementsCode 'NYLE' for 10% off - proceeds go towards upgrading content productionHuge Supplements (Protein, Pre, Utilize, Vital): https://hugesupplements.com/?aff=165Support code 'NYLE' 10% offYoungLA Clothes: https://www.youngla.com/discount/nyleYoungLA For Her: https://www.youngla.com/collections/all-products-1/For-HerCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastCoaching | Personalized program:  https://www.nylenaygafitness.com00:00:00 - Teaser & Intro00:04:23 - 4% body fat00:05:17 - Christopher Reeve00:07:18 - Kyle00:12:59 - P5P & Caffean00:13:28 - Semen retention documentary00:13:53 - “Only Trans”00:20:12 - Thoughts on marriage00:27:56 - Delayed Gratification00:34:34 - Manifestation & Matuarity00:41:08 - Learn the hard way00:45:22 - Cure to cancer00:47:20 - "God's nectar"00:49:33 - Overcoming addictions00:55:07 - Same room as Billionaires00:57:08 - Social media mentor01:00:49 - "How to make a 3 Million dollars a year"01:04:04 - Thoughts on prenup01:08:18 - What's your perspective on Kids & Steroids?01:11:28 - "Steroids dial"01:18:14 - Noel Deyzel01:19:54 - Immediate vs Calculated reaction01:21:20 - What's the youngest age you've ever heard a kid be on steroids?01:25:11 - What's the craziest cycle you've heard01:28:25 - Q & A01:36:22 - Jay Cutler & the Hummer01:41:24 - What's your macro to weight ratio when cutting?01:44:47 - Do you plan on going back to bodybuilding?01:48:46 - What's one thing you wish you could change in the fitness industry?01:50:45 - "Chew & Spit"#psychology #stories #podcast #mentalhealth #discipline #selfdevelopment #personaldevelopment #fitness #ifbbpro #npc #bodybuilder #bodybuilding #tiktok #shizzy #olympia #mrolympia #2023olympia #selfimprovement #workout #gym #nutrition #mensphysique #classicphysique #love #discipline #relationships #chrisbumstead #tren #workout #gym #trt #hormones #discipline #hardstyle #steroids #larrywheels

It's a pretty common understanding that B vitamins are an important nutrient we all need, but do you ever wonder what each B vitamin does for you? Do you wonder which one you should take or if you should be taking a B-Complex? On this episode of Vitality Radio, Jared explains the role of each of the B vitamins and answers those questions. You'll learn about methylation, MTHFR, and why the form of your B vitamins matter and also about a very specific B vitamin almost nobody knows about! Products MentionedAdditional Information:#329: MTHFR Mutations, Methylated B Vitamins, Folic Acid vs. Methylfolate and more with Carrie Pattison#346: The Ultimate Vitality Multi - What Makes It the Ultimate Multivitamin for YouBe Healthy UtahBe Healthy Utah discount code: vitality40Visit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Guest: Hiatt My name is Aaron Hiatt. I have been in the HTMA field for about 10 years now and have analyzed over hundreds of hair tests. I originally got into hair analysis testing while in college after battling some health issues. I have experienced a lot of health improvements following the teachings of Dr. Paul Eck and Dr. Wilson Lawrence. I continue to expand my own understanding and knowledge across many areas of research concerning the human body.    Website: https://redoxstasis.com/store/arl-hair-analysis-test-kit?fbclid=PAAabxbLL7bDkK7-BxfRCVhZFeVzxpSJpqjKA4eAzwJV5oHUVZi1JkHFh8Za0    Valence Nutraceuticals: Use code ITP20 for 20% off https://valencenutraceuticals.myshopify.com/   Summary This conversation explores the importance of mineral balancing and the benefits of mineral orotates, with a focus on the work of Dr. Hans Nieper and Dr. Paul Eck. The chapters cover topics such as the science behind mineral orotates, the difference between orotates and amino acid chelates, the improvements in mineral supplements, and the legacy of Dr. Paul Eck. The conversation also discusses the dosage and absorption of magnesium orotate, the continued research and development in supplement formulations, and the importance of collaboration and improvement in the field. This conversation covers various topics related to the utilization and benefits of different vitamins and minerals. The chapters include discussions on the impact of alkaline phosphatase on B6 utilization, the comparison of active B complex supplements, the importance of manganese for thiamine utilization, the benefits of a community-based healthcare system, the effectiveness of bioavailable forms of vitamins, the advantages of tocotrienols over tocopherols, research on tocotrienols in Russia and Germany, the superior antioxidant potential of tocotrienols, the research on potassium orotate, the anxiolytic effect of potassium orotate, the difference between folate and folic acid, the ratio of adenosylcobalamin to methylcobalamin in meat, the benefits of adenosylcobalamin over methylcobalamin, the superior absorption of selenoxale, the benefits of methyl selenocysteine, the role of selenoxale in circadian rhythm, gender differences in selenium supplementation, the benefits of chromium picolinate, the comparison of chromium polynicotinate and chromium picolinate, the impact of chromium on PCOS, and the benefits of PQQ for mitochondrial health.   Chapters 00:00 Introduction and Background 03:09 The Importance of Mineral Balancing 14:53 Mineral Orotates and Dr. Hans Nieper 21:11 The Science Behind Mineral Orotates 32:54 The Difference Between Mineral Orotates and Amino Acid Chelates 38:05 Improvements in Mineral Supplements 41:47 The Benefits of Magnesium Orotate 44:17 Dosage and Absorption of Magnesium Orotate 51:28 Continued Research and Development 54:08 The Legacy of Dr. Paul Eck 59:17 Updates in Supplement Formulations 01:05:15 Collaboration and Improvement 01:08:16 The Importance of P5P in B6 Supplementation 01:13:06 Impact of Alkaline Phosphatase on B6 Utilization 01:14:27 Comparison of Active B Complex Supplements 01:15:36 Importance of Manganese for Thiamine Utilization 01:16:11 Benefits of Community-Based Healthcare System 01:17:12 Effectiveness of Bioavailable Forms of Vitamins 01:18:47 Advantages of Tocotrienols over Tocopherols 01:19:12 Research on Tocotrienols in Russia and Germany 01:20:41 Superior Antioxidant Potential of Tocotrienols 01:21:29 Research on Tocopherol vs Tocotrienol 01:21:56 Personal Experience with Tocotrienols 01:22:49 Research on Potassium Orotate 01:23:39 Research on Potassium Orotate in Russia and Germany 01:24:38 Anxiolytic Effect of Potassium Orotate 01:25:04 Effect of Adrenal Dysfunction on Potassium Levels 01:25:43 Comparison of Potassium Orotate and Potassium Aspartate 01:26:59 Reason for Using Potassium Orotate in Slow Oxidizers 01:27:38 Benefits of Methyl Tetrahydrofolate (5-MTHF) 01:28:37 Dangers of Synthetic Folic Acid 01:29:17 Difference Between Folate and Folic Acid 01:30:31 Ratio of Adenosylcobalamin to Methylcobalamin in Meat 01:31:53 Advantages of Adenosylcobalamin over Methylcobalamin 01:33:43 Superior Absorption of Selenoxale 01:34:13 Benefits of Methyl Selenocysteine 01:35:09 Role of Selenoxale in Circadian Rhythm 01:36:20 Gender Differences in Selenium Supplementation 01:37:41 Benefits of Chromium Picolinate 01:38:37 Comparison of Chromium Polynicotinate and Chromium Picolinate 01:40:21 Impact of Chromium on PCOS 01:41:43 Benefits of PQQ for Mitochondrial Health     Advertisements:   Valence Nutraceuticals: Use code ITP20 for 20% off https://valencenutraceuticals.myshopify.com/   Zeolite Labs Zeocharge: Use Code ITP for 10% off https://www.zeolitelabs.com/product-page/zeocharge?ref=ITP Magnesium Breakthrough: Use Code integrativethoughts10 for 10% OFF https://bioptimizers.com/shop/products/magnesium-breakthrough Just Thrive: Use Code ITP15 for 15% off https://justthrivehealth.com/discount/ITP15 Therasage: Use Code Coffman10 for 10% off https://www.therasage.com/discount/COFFMAN10?rfsn=6763480.4aed7f&utm_source=refersion&utm_medium=affiliate&utm_campaign=6763480.4aed7f Nootopia: Use Code IntegrativeThoughts10 for 10% OFF https://nootopia.com/ Sleep Breakthrough: Use Code IntegrativeThoughts10 for 10% OFF https://bioptimizers.com/shop/products/sleep-breakthrough Matt Coffman / Integrative Thoughts My Instagram: @integrativematt My Website: Integrativethoughts.com  

Today I'm going to share three common nutritional deficiencies related to sciatica and carpal tunnel syndrome and ways to tell which one might be affecting you most. Vitamins B1, B6, and B12 are intimately involved in the nervous system and may be behind these painful conditions. 1. Vitamin B6 benefits • Helps build the myelin sheath • Helps produce neurotransmitters • Helps protect sensory nerve integrity • Helps increase nerve conduction and velocity • Is involved in the metabolism of the nervous system Vitamin B6 deficiency causes: • Taking the wrong form of vitamin B6 in large amounts • Gut inflammation • Celiac disease • Crohn's disease • Age • Certain medications • Alcohol • Birth control pills • Certain genetic variations • Smoking • Diabetes • Excess coffee consumption * It's important to take the active form of vitamin B6, pyridoxal-5-phosphate (P5P). 2. Vitamin B12 benefits: • Helps support nerve regeneration • Helps support myelin production • Helps support nerve growth factors Vitamin B12 deficiency causes: • Certain genetic factors • Lack of animal products in the diet • Low stomach acid • Excess consumption of folic acid • Alcohol • Diabetes • Malabsorption • Birth control pills * It's important to take the natural form of vitamin B12, methylcobalamin. 3. Vitamin B1 (thiamine) benefits: • Helps support blood flow to the nerves • Helps counter the complications of diabetes Vitamin B1 deficiency causes: • Diabetes, prediabetes, and insulin resistance • Excess coffee consumption • Excess tea consumption * It's important to take the fat-soluble version of vitamin B1, benfotiamine. DATA: https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/30712... https://www.ncbi.nlm.nih.gov/pmc/arti...

How long to notice High Dose GH? Low Test + High Ananbolics, Back Training Technique, P5P for Prolactin TIME STAMPS BELOW Coaches Skip Hill, Andrew Berry, Scott McNally Coaches Skip Hill, Andrew Berry, Scott McNally take listener questions TIME STAMPS BELOW

Drugs n Stuff 179 - Traveling on Steroids. How do you handle your cycle while traveling? Dave Crosland & Scott McNally

Question: How do I fix low blood sugar on vegan keto? Short Answer: Consider how important it is for your ketones to be elevated. Most likely you need to eat more protein, which will lower your ketones. I would aim for a minimum of 0.8 grams per kilogram of ideal bodyweight and consider using 1.2 grams per kilogram of ideal bodyweight. If this does not work, consider all of the nutrients involved in energy metabolism — all of the B vitamins, iron, copper, sulfur, magnesium, potassium — but especially biotin and B6 for their disproportionate role in gluconeogenesis. If the protein you need to normalize your blood sugar does reduce your ketones to a level that are not giving you the benefits you are looking for, you could consider raising them with exogenous ketones. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Brain Fog on Calcium, Vitamin D, or K2 Raising Ceruloplasmin When Copper Won't Do It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Brain Fog on Calcium, Vitamin D, or K2 How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? How do I get my ceruloplasmin up if copper doesn't raise it? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here.

Question: Why would vitamin D, vitamin K2, and calcium give me brain fog? Short Answer: Most likely by decreasing serum phosphorus. The solution is to balance these nutrients with vitamin A and phosphorus. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Low Blood Sugar on Vegan Keto Raising Ceruloplasmin When Copper Won't Do It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Low Blood Sugar on Vegan Keto How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? How do I get my ceruloplasmin up if copper doesn't raise it? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here.

DRUGS N STUFF BODYBUILDING PODCAST 115 DAVE CROSLAND AND SCOTT MCNALLY ANSWER LISTENER QUESTIONS - TIME STAMPS BELOW

Dave Crosland and Scott McNally talk steroid synergy and answer performance enhancing drug questions from listeners. TIME STAMPS BELOW. Comment to have your question on the next show!

HOUR 2 How Magnesium Vitamin D and Calcium Play Together-Carolyn Dean MD ND  When considering this equation, it must be understood that all these nutrients work synergistically and require co-factors to be successful in performing their functions in the body. In addition to magnesium, calcium, and vitamin D, Dr. Carolyn Dean, one of the world's leading experts on vitamin and mineral supplementation, also recommends vitamin K-2 for the metabolism of calcium, ReAline for the absorbable form of vitamin B-6 that works with magnesium, and ReMyte Mineral Solution for the multi-minerals that are require to support vitamin D metabolism as well as inviting potassium and selenium to the party!  Let’s see if we can get this all sorted out. Getting the ratios right might look something like this:  Start with Diet: Whole, complete foods including healthy proteins, lots of fruits, and properly-prepared vegetables. Avoid processed foods, sugars, and other unsavory food products that diminish health and vitality.  Focus on proper Hydration - many of our radio show listeners know that Dr. Dean recommends drinking 1/2 your body weight (in lbs) in ounces of water daily with at least 1/4 tsp of trace mineral sea salt in each liter.  ReMag is necessary for 80% of known metabolic function, so it’s a must-have mineral that works synergistically with all the vitamins and minerals in the body. However, even with a good diet you’ll get less magnesium from your food than you would have 100 years ago because of the demineralization of the soil. This is why it’s so important to get your ReMag daily. Either follow the protocol by sipping through the day or take it in juice, green tea, or a smoothie with your meals 2 or 3 times a day. Be sure to drink your sea-salted water throughout the day as well.  Calcium is essential for the strength and development of bones and teeth. Few people know that calcium is regulated and controlled by magnesium. Calcium is important for the transmission of impulses in nerve and muscle cells, including cardiac muscle cells. Even so, calcium can’t deliver without the balancing effect of magnesium. Magnesium opens the cells to receive a measured amount of calcium, then, after the muscle or nerve action has been performed, magnesium drives the calcium out of the cell. Calcium also has an important role in blood clotting. But that might mean that the calcification people are experiencing by taking calcium supplements is a cause of the thick blood that so many people have these days, leading to the over-prescription of blood thinning drugs. Our body holds on to calcium much more than magnesium. That may be because human beings grew up near the ocean where seawater contains three times more magnesium than calcium, which meant they had much more magnesium in their diet. Thus, we evolved mechanisms that grabbed and stored calcium but released excess magnesium (the laxative effect). Without understanding those processes, it has been suggested that we require more calcium than we do. Dr. Dean recommends a 1:1 balance of calcium to magnesium and takes the calcium RDA from the UK (700mg) and the WHO (500-600mg). Try to get 600mg of calcium in through your diet, which includes yogurt, green leafy vegetables, and bone broth. And, for those who are dairy-free you can get 300 mgs of calcium per serving with ReCalcia, Dr. Dean's picometer calcium solution.  Vitamin D is made by the body through summer sun exposure. There’s an app for your iPhone called D minder that estimates how much vitamin D you make from the sun depending on where you are, skin type, time of year, time of day, etc. However, you require magnesium to convert sunshine vitamin D into active vitamin D. Another resource to know your vitamin D level is to participate in the GrassrootsHealth vitamin D research project, which you can join from our website RnA ReSet and click on Research.  To get the most benefit from vitamin D you have to have the other co-factors in your body as well – those include magnesium, Vitamin K, Zinc, Boron and Vitamin A.   Vitamin K2 is needed to get calcium directed to where it needs to be, in bones and teeth, not arteries, and it protects against vitamin D toxicity. Like magnesium, nearly everyone is deficient, because our eggs and butter and other natural sources are either missing from the diet or come from industrially raised animals not fed on grass. Vitamin K2 supplementation may dramatically reduce fracture rates and even reverses arterial calcification.  Vitamin B-6 - AKA pyridoxal-5-phosphate works as a coenzyme to assist in an amazing variety of tasks – the creation of heme, the iron-containing component of red blood cells; making the hormone serotonin (the “feel good” hormone); processing carbohydrates for energy; keeping the nervous system working smoothly, and supporting hundreds of other biological functions. Having low levels of this key nutrient can lead to skin disorders, depression, dizziness, headaches, and other, more serious problems, such as heart attacks and strokes.  Pyridoxal-5-Phosphate, or P5P as it is commonly known, is the active form of vitamin B6 found in Dr. Dean’s formula, ReAline. In foods or most supplements, vitamin B6 is found in one of three forms: pyridoxine hydrochloride, pyridoxal, or pyridoxamine. Inside the body, these forms of B6 have to be converted by the liver to the active form the body needs – P5P.  Low rates of conversion from the inactive to the active form of vitamin B6 have been reported, especially in people with impaired liver function, Celiac disease, older adults, and in children with autism. By consuming vitamin B6 in the active P5P form, conversion is no longer necessary, and the full benefits are available immediately. Working hand-in-hand with the 100% bio-available ReMag, Vitamin B-6 will boost the performance of your energy production and nervous system to your benefit.    Essential Fatty Acids - EFAs increase calcium absorption from the gut, in part by enhancing the effects of vitamin D. They also regulate and reduce urinary excretion of calcium, possibly by reducing production of pro-inflammatory molecules called prostaglandins. EFAs have also been found to increase calcium deposition in bone, which is not surprising since bone calcification must take place in the presence of a type of fat known as a phospholipid. Finally, essential fatty acids appear to support collagen production by modulating the inflammatory response that interferes with collagen synthesis. Our soon-to-be released Omega-3 Algae A+E provides you with the necessary EFAs for optimal health.  So join us tonight for the rest of Dr. Dean’s powerful, preventive protocols and information! You will love hearing the beneficial interactions with our callers and hosts alike and answers to some of today’s most important health prevention topics including the body/mind connection, identifying the 'conflict' in the 'conflict basis' of disease and much more!!  About Dr. Carolyn Dean  Dr Carolyn Dean MD ND has been featured on national media for over 30 years offering practical strategies to improve health, vitality, and well-being the natural way. As a medical doctor, naturopath, certified clinical nutritionist and master of many modalities including acupuncture and homeopathy, Dr. Carolyn Dean MD ND has authored over 33 books and 100 publications including The Magnesium Miracle, 3rd Edition, Hormone Balance, Future Health Now Encyclopedia and Heart Health. Please note that the information and opinions expressed on these broadcasts are not designed to constitute advice or recommendations as to any disease, ailment, or physical condition. You should not act or rely upon any information contained in these broadcasts without seeking the advice of your personal physician. If you have any questions about the information or opinions expressed during these broadcasts, please contact your doctor.  Disclosure: Dr. Dean does have a financial interest in the sale of all the Completement Formulas.  Video Version:  https://youtu.be/hNjYTLASjKI  Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand  Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.com We will be glad to respond to your email  Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com  

HOUR 1 How Magnesium Vitamin D and Calcium Play Together-Carolyn Dean MD ND  When considering this equation, it must be understood that all these nutrients work synergistically and require co-factors to be successful in performing their functions in the body. In addition to magnesium, calcium, and vitamin D, Dr. Carolyn Dean, one of the world's leading experts on vitamin and mineral supplementation, also recommends vitamin K-2 for the metabolism of calcium, ReAline for the absorbable form of vitamin B-6 that works with magnesium, and ReMyte Mineral Solution for the multi-minerals that are require to support vitamin D metabolism as well as inviting potassium and selenium to the party!  Let’s see if we can get this all sorted out. Getting the ratios right might look something like this:  Start with Diet: Whole, complete foods including healthy proteins, lots of fruits, and properly-prepared vegetables. Avoid processed foods, sugars, and other unsavory food products that diminish health and vitality.  Focus on proper Hydration - many of our radio show listeners know that Dr. Dean recommends drinking 1/2 your body weight (in lbs) in ounces of water daily with at least 1/4 tsp of trace mineral sea salt in each liter.  ReMag is necessary for 80% of known metabolic function, so it’s a must-have mineral that works synergistically with all the vitamins and minerals in the body. However, even with a good diet you’ll get less magnesium from your food than you would have 100 years ago because of the demineralization of the soil. This is why it’s so important to get your ReMag daily. Either follow the protocol by sipping through the day or take it in juice, green tea, or a smoothie with your meals 2 or 3 times a day. Be sure to drink your sea-salted water throughout the day as well.  Calcium is essential for the strength and development of bones and teeth. Few people know that calcium is regulated and controlled by magnesium. Calcium is important for the transmission of impulses in nerve and muscle cells, including cardiac muscle cells. Even so, calcium can’t deliver without the balancing effect of magnesium. Magnesium opens the cells to receive a measured amount of calcium, then, after the muscle or nerve action has been performed, magnesium drives the calcium out of the cell. Calcium also has an important role in blood clotting. But that might mean that the calcification people are experiencing by taking calcium supplements is a cause of the thick blood that so many people have these days, leading to the over-prescription of blood thinning drugs. Our body holds on to calcium much more than magnesium. That may be because human beings grew up near the ocean where seawater contains three times more magnesium than calcium, which meant they had much more magnesium in their diet. Thus, we evolved mechanisms that grabbed and stored calcium but released excess magnesium (the laxative effect). Without understanding those processes, it has been suggested that we require more calcium than we do. Dr. Dean recommends a 1:1 balance of calcium to magnesium and takes the calcium RDA from the UK (700mg) and the WHO (500-600mg). Try to get 600mg of calcium in through your diet, which includes yogurt, green leafy vegetables, and bone broth. And, for those who are dairy-free you can get 300 mgs of calcium per serving with ReCalcia, Dr. Dean's picometer calcium solution.  Vitamin D is made by the body through summer sun exposure. There’s an app for your iPhone called D minder that estimates how much vitamin D you make from the sun depending on where you are, skin type, time of year, time of day, etc. However, you require magnesium to convert sunshine vitamin D into active vitamin D. Another resource to know your vitamin D level is to participate in the GrassrootsHealth vitamin D research project, which you can join from our website RnA ReSet and click on Research.  To get the most benefit from vitamin D you have to have the other co-factors in your body as well – those include magnesium, Vitamin K, Zinc, Boron and Vitamin A.   Vitamin K2 is needed to get calcium directed to where it needs to be, in bones and teeth, not arteries, and it protects against vitamin D toxicity. Like magnesium, nearly everyone is deficient, because our eggs and butter and other natural sources are either missing from the diet or come from industrially raised animals not fed on grass. Vitamin K2 supplementation may dramatically reduce fracture rates and even reverses arterial calcification.  Vitamin B-6 - AKA pyridoxal-5-phosphate works as a coenzyme to assist in an amazing variety of tasks – the creation of heme, the iron-containing component of red blood cells; making the hormone serotonin (the “feel good” hormone); processing carbohydrates for energy; keeping the nervous system working smoothly, and supporting hundreds of other biological functions. Having low levels of this key nutrient can lead to skin disorders, depression, dizziness, headaches, and other, more serious problems, such as heart attacks and strokes.  Pyridoxal-5-Phosphate, or P5P as it is commonly known, is the active form of vitamin B6 found in Dr. Dean’s formula, ReAline. In foods or most supplements, vitamin B6 is found in one of three forms: pyridoxine hydrochloride, pyridoxal, or pyridoxamine. Inside the body, these forms of B6 have to be converted by the liver to the active form the body needs – P5P.  Low rates of conversion from the inactive to the active form of vitamin B6 have been reported, especially in people with impaired liver function, Celiac disease, older adults, and in children with autism. By consuming vitamin B6 in the active P5P form, conversion is no longer necessary, and the full benefits are available immediately. Working hand-in-hand with the 100% bio-available ReMag, Vitamin B-6 will boost the performance of your energy production and nervous system to your benefit.    Essential Fatty Acids - EFAs increase calcium absorption from the gut, in part by enhancing the effects of vitamin D. They also regulate and reduce urinary excretion of calcium, possibly by reducing production of pro-inflammatory molecules called prostaglandins. EFAs have also been found to increase calcium deposition in bone, which is not surprising since bone calcification must take place in the presence of a type of fat known as a phospholipid. Finally, essential fatty acids appear to support collagen production by modulating the inflammatory response that interferes with collagen synthesis. Our soon-to-be released Omega-3 Algae A+E provides you with the necessary EFAs for optimal health.  So join us tonight for the rest of Dr. Dean’s powerful, preventive protocols and information! You will love hearing the beneficial interactions with our callers and hosts alike and answers to some of today’s most important health prevention topics including the body/mind connection, identifying the 'conflict' in the 'conflict basis' of disease and much more!!  About Dr. Carolyn Dean  Dr Carolyn Dean MD ND has been featured on national media for over 30 years offering practical strategies to improve health, vitality, and well-being the natural way. As a medical doctor, naturopath, certified clinical nutritionist and master of many modalities including acupuncture and homeopathy, Dr. Carolyn Dean MD ND has authored over 33 books and 100 publications including The Magnesium Miracle, 3rd Edition, Hormone Balance, Future Health Now Encyclopedia and Heart Health. Please note that the information and opinions expressed on these broadcasts are not designed to constitute advice or recommendations as to any disease, ailment, or physical condition. You should not act or rely upon any information contained in these broadcasts without seeking the advice of your personal physician. If you have any questions about the information or opinions expressed during these broadcasts, please contact your doctor.  Disclosure: Dr. Dean does have a financial interest in the sale of all the Completement Formulas.  Video Version:  https://youtu.be/hNjYTLASjKI  Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand  Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.com We will be glad to respond to your email  Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com  

Savage recaps the NFL Pick'em Games, rants about the CFP (or P5P as he calls it), previews the NBA season and finishes up with his Naughty or Nice List in the world of sports. Merry Christmas and Happy Holidays! Follow on Twitter: @IDKSportsPod --- Support this podcast: https://anchor.fm/idk-sports-pod/support

females on anabolics The Steroids Podcast Episode 40 ULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING https://bodybuilderinthailand.com/ultimate-guide-to-roids/ Listen to the Bodybuilding Podcast on ITunes and Spotify! 0:00 the chemistry of vaccines 6:30 rDNA technology 9:00 What I would say to people when i was a ROID BEGINNER and people asked me how i was getting so big and if i was on gear 11:40 Women angry at you about taking steroids 14:10 Genetics and Bodybuilding 22:31 drug test for work 27:05 Risk Factors for Infections from Steroid Injections 32:13 High Testosterone + 19-NOR , what ancillaries are necessary 36:30 Can NPP cause Deca Dick? 39:12 Tren Gyno 41:40 Eating to Grow on Testosterone Only Cycles 44:15 Anavar stacked with Winstrol 48:45 Short Cruise between cycles What to Use for PCT 51:23 Anxiety Attack on Steroids 54:43 1000mg test 1000mg deca + Dbol ancillaries required 56:35 Bunk Cabergoline getting Tren Gyno now P5P 1:01:15 Women and Steroids This Podcast is for entertainment and conversational purposes only. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.

HOUR 2Building Blocks for Cardiovascular Health -- Carolyn Dean MD ND Cardiovascular health is not constructed on the basis of a single nutrient or a single approach. Instead, the key building blocks for cardiovascular performance work holistically and synergistically to achieve their health outcomes. Actually, ALL nutrients work together to perform their functions in the body. Longitudinal clinical studies on the effects of nutrients on cardiovascular health point to several true ‘GIANTS’ in the field: magnesium, potassium, vitamin B6, B12, vitamin C and D3/K2. Dietary intake of whole food  Sustaining health and well-being starts by a review of your dietary intake of fresh, whole food. Start with whole, complete foods including healthy proteins, only a few servings of fruit a day, and raw or lightly cooked vegetables. Avoid processed foods and oils, sugars, and gluten that diminish health and vitality. Even with a good diet, you’ll get less magnesium, minerals, and vitamins in your food than you would have gotten 30 years ago because of the way our farmland has been depleted and our food is being heavily processed. The Benefits of Dietary Supplements To complete your diet and optimize your cardiovascular performance it’s important to take highly absorbed, food-based, meticulously prepared formulas created by Dr. Carolyn Dean. Here’s a list of where to start and why:Magnesium is an essential mineral that serves as a structural component of the skeleton; assists in 1,000 enzymatic reactions involved in the synthesis of energy, DNA, and proteins; and is required for proper nerve conduction and muscle contraction. The way in which magnesium influences cardiac health is well researched and well documented. Magnesium supports vascular health, lowers inflammatory mediators and reduce a angiotensin-induced aldosterone synthesis, all of which can lower blood pressure. Dr. Dean's magnesium recommendation: ReMag Magnesium Solution. Vitamin D is actually a hormone and is made by the body through summer sun exposure, 30 minutes if you have fair skin with as much skin exposed as possible. If you can’t get proper exposure to the sun, then Dr. Dean recommends supplementing with Vitamin D. To get the most benefit from vitamin D you have to have the other co-factors in your body as well – those include magnesium, vitamin K2, zinc, and boron. Both zinc and boron can be found in ReMyte Mineral Solution – ReMag’s sister mineral product and you can get vitamin D3K2 from Dr. Dean’s D2K2ReSet. Vitamin K2 is needed to get calcium in the body where it needs to be, in bones and teeth, not arteries, and it protects against vitamin D toxicity. Like magnesium, nearly everyone is deficient, because our eggs and butter and other natural sources are either missing from the diet or come from industrially raised animals not fed on grass. Vitamin K2 supplementation may dramatically reduce fracture rates and even reverses arterial calcification. Vitamin B-6 – Vitamin B6 (pyridoxal-5-phosphate). As a coenzyme, vitamin B6 assists in an amazing variety of tasks – the creation of heme, the iron-containing component of red blood cells; making the hormone serotonin (the “feel good” hormone); processing carbohydrates for energy; keeping the nervous system working smoothly, and supporting hundreds of other jobs. Having low levels of this key nutrient can lead to skin disorders, depression, dizziness, headaches, and other, more serious problems, such as heart attacks and strokes.  Pyridoxal-5-Phosphate, or P5P as it is commonly known, is the active form of vitamin B6 found in Dr. Dean’s product, ReAline.  In foods or most supplements, vitamin B6 is found in one of three forms: pyridoxine hydrochloride, pyridoxal, or pyridoxamine. Inside the body, these forms of B6 have to be converted by the liver to the active form the body needs – P5P.  Low rates of conversion from the inactive to the active form of vitamin B6 have been reported, especially in people with impaired liver function, Celiac’s disease, older adults, and in children with autism. By consuming vitamin B6 in the active P5P form, conversion is no longer necessary, and the full benefits are available immediately after absorption. Vitamin C - Vitamin C (ascorbic acid) neutralizes a variety of reactive oxygen species and recycles important cellular antioxidants. The antioxidant activities of vitamin C may protect the lining of blood vessels from damage caused by oxidative stress and increase the availability of nitric oxide, a gaseous signaling molecule that helps relax arterial walls. Vitamin C ReSet is a really fun way to get your daily dose of vitamin C in a sparkly, delicious berry drink! Tonight on Dr. Carolyn Dean LIVE we'll be talking with Dr. Carolyn Dean about Building Blocks for Cardiovascular Health along with a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with callers and hosts alike including the body/mind connection, identifying the 'conflict' in the 'conflict basis' of disease and much more!! Remember, the valuable information, suggestions, and insights about your health choices should always be discussed with your doctor. Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.comWe will be glad to respond to your email Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com

HOUR 1Building Blocks for Cardiovascular Health -- Carolyn Dean MD ND Cardiovascular health is not constructed on the basis of a single nutrient or a single approach. Instead, the key building blocks for cardiovascular performance work holistically and synergistically to achieve their health outcomes. Actually, ALL nutrients work together to perform their functions in the body. Longitudinal clinical studies on the effects of nutrients on cardiovascular health point to several true ‘GIANTS’ in the field: magnesium, potassium, vitamin B6, B12, vitamin C and D3/K2. Dietary intake of whole food  Sustaining health and well-being starts by a review of your dietary intake of fresh, whole food. Start with whole, complete foods including healthy proteins, only a few servings of fruit a day, and raw or lightly cooked vegetables. Avoid processed foods and oils, sugars, and gluten that diminish health and vitality. Even with a good diet, you’ll get less magnesium, minerals, and vitamins in your food than you would have gotten 30 years ago because of the way our farmland has been depleted and our food is being heavily processed. The Benefits of Dietary Supplements To complete your diet and optimize your cardiovascular performance it’s important to take highly absorbed, food-based, meticulously prepared formulas created by Dr. Carolyn Dean. Here’s a list of where to start and why:Magnesium is an essential mineral that serves as a structural component of the skeleton; assists in 1,000 enzymatic reactions involved in the synthesis of energy, DNA, and proteins; and is required for proper nerve conduction and muscle contraction. The way in which magnesium influences cardiac health is well researched and well documented. Magnesium supports vascular health, lowers inflammatory mediators and reduce a angiotensin-induced aldosterone synthesis, all of which can lower blood pressure. Dr. Dean's magnesium recommendation: ReMag Magnesium Solution. Vitamin D is actually a hormone and is made by the body through summer sun exposure, 30 minutes if you have fair skin with as much skin exposed as possible. If you can’t get proper exposure to the sun, then Dr. Dean recommends supplementing with Vitamin D. To get the most benefit from vitamin D you have to have the other co-factors in your body as well – those include magnesium, vitamin K2, zinc, and boron. Both zinc and boron can be found in ReMyte Mineral Solution – ReMag’s sister mineral product and you can get vitamin D3K2 from Dr. Dean’s D2K2ReSet. Vitamin K2 is needed to get calcium in the body where it needs to be, in bones and teeth, not arteries, and it protects against vitamin D toxicity. Like magnesium, nearly everyone is deficient, because our eggs and butter and other natural sources are either missing from the diet or come from industrially raised animals not fed on grass. Vitamin K2 supplementation may dramatically reduce fracture rates and even reverses arterial calcification. Vitamin B-6 – Vitamin B6 (pyridoxal-5-phosphate). As a coenzyme, vitamin B6 assists in an amazing variety of tasks – the creation of heme, the iron-containing component of red blood cells; making the hormone serotonin (the “feel good” hormone); processing carbohydrates for energy; keeping the nervous system working smoothly, and supporting hundreds of other jobs. Having low levels of this key nutrient can lead to skin disorders, depression, dizziness, headaches, and other, more serious problems, such as heart attacks and strokes.  Pyridoxal-5-Phosphate, or P5P as it is commonly known, is the active form of vitamin B6 found in Dr. Dean’s product, ReAline.  In foods or most supplements, vitamin B6 is found in one of three forms: pyridoxine hydrochloride, pyridoxal, or pyridoxamine. Inside the body, these forms of B6 have to be converted by the liver to the active form the body needs – P5P.  Low rates of conversion from the inactive to the active form of vitamin B6 have been reported, especially in people with impaired liver function, Celiac’s disease, older adults, and in children with autism. By consuming vitamin B6 in the active P5P form, conversion is no longer necessary, and the full benefits are available immediately after absorption. Vitamin C - Vitamin C (ascorbic acid) neutralizes a variety of reactive oxygen species and recycles important cellular antioxidants. The antioxidant activities of vitamin C may protect the lining of blood vessels from damage caused by oxidative stress and increase the availability of nitric oxide, a gaseous signaling molecule that helps relax arterial walls. Vitamin C ReSet is a really fun way to get your daily dose of vitamin C in a sparkly, delicious berry drink! Tonight on Dr. Carolyn Dean LIVE we'll be talking with Dr. Carolyn Dean about Building Blocks for Cardiovascular Health along with a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with callers and hosts alike including the body/mind connection, identifying the 'conflict' in the 'conflict basis' of disease and much more!! Remember, the valuable information, suggestions, and insights about your health choices should always be discussed with your doctor. Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.comWe will be glad to respond to your email Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com

Most children with autism and other neurological imbalances can become calmer, happier, have better focus, and retain information far better with the use of natural supplementation to assist their brain. Healing the biology from toxins, inflammation and infections is critical. Please see my free webinar to learn about each of these, and how it can be done safely, and naturally. The following are informational examples of options for assisting  brain function with natural supplementation. First, let’s learn a little bit about neurotransmitters. Serotonin Serotonin is a key brain chemical that is been identified in the physiological abnormalities in ASD and AD/HD.  Serotonin is made from tryptophan with the help of vitamin C, folate, iron, calcium and vitamin B6.  Tryptophan is an amino acid, which is a building block of protein.  Children with developmental disorders often show amino acid deficiency including tryptophan.  They also have an inability to effectively convert B6 to its active form P5P. Serotonin is responsible for regulating: Learning Memory Sensory Perception Noise sensitivity Mood Behaviour Sleep Appetite The natural supplement 5HTP builds serotonin. Gut dysbiosis, as well as heavy metals can also effect levels of serotonin and dopamine. Click Here or Click the link below for more details. https://naturallyrecoveringautism.com/81

Question: What to do when serum magnesium is high but RBC magnesium is low? The magnesium in the blood and the hair is high. When you say blood, I'm assuming this is serum or plasma because the RBC magnesium is low. I'm hoping that's not whole blood magnesium in which case it would be hard to separate from the RBC magnesium. But I mean even for whole blood, if the RBC magnesium is low and the blood magnesium is high, then the magnesium that's in the blood that's high is in the serum or plasma, not in the RBCs obviously. Clearly this means that you're deficient in magnesium transport. You're not deficient in magnesium. So, the last thing that you should do is start blasting high-dose magnesium at that. Because not only is it not going to help, but you basically have two or three times the risk of harm from supplementing high-dose magnesium, because the harm of high-dose magnesium comes when your serum levels go to double the upper limit of the reference range. If your serum level is high, and your RBC is low, and you start blasting. B6, even if it's adequate, maybe try 10 milligrams. Work your way slowly up to 100 milligrams of P5P. See if that helps. If it doesn't, you probably have a more serious issue with magnesium transport. You might have a rare genetic defect in a magnesium transporter. Off the top of my head, I'm not sure how to manage that. There's probably things you can't do. It might come down to just maximizing all the different possible ways that you can get magnesium into your system and cells. That might mean that you want a modest hypermagnesemia. In other words, you want your serum magnesium to be a little over the top of the upper reference range in order to try to drive magnesium into the red blood cells. But you still need to measure it regularly so that you know that you're not anywhere near twice the top of the upper reference range. Then just do what you can to maximize the other factors. Insulin, salt, and B6 is what I think there. This Q&A can also be found as part of a much longer episode, here: https://chrismasterjohnphd.com/podcast/2019/03/30/ask-anything-nutrition-march-4-2019 If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

Question: For someone who is taking 45 mg of vitamin B6 as P5P but has xanthurenate, kynurenate, and quinolinate high in the urine as markers of vitamin B6 deficiency, and who is a man with high estrogen, what should they do?   If you have xanthurenate and kynurenate spilling into your urine, it means that quinolinate would be building up. Quinolinate is usually the last thing to rise in B6 deficiency.    Quinolinate is an excitotoxin: it both can cause neurotoxicity like glutamate does and it can also make you hypersensitive to glutamate, effectively giving you a glutamate sensitivity.   You clarified that quinolinate is in the fourth quintile. So you're kind of in the zone quinolinate might be a problem, particularly if you have trouble sleeping, or if you have trouble with anxiety, or you have anything that would be related to glutamate sensitivity, like headaches.    If you have any of those symptoms, they could be from quinolinate buildup. In that case, I recommend increasing B6. I would titrate it up to 100 mg. I'd be very cautious going higher than that. Don't take any pyridoxine hydrochloride ever.   Second course of action is look at iron and riboflavin levels. If there's any things wrong with those fix them, since they are needed to properly convert tryptophan alongside B6.   Third course of action is to reduce protein intake, if necessary, or search for low tryptophan proteins and focus on those to meet your protein needs. You need at least a few hundred milligrams of tryptophan in your diet to be okay. This Q&A can also be found as part of a much longer episode, here: https://chrismasterjohnphd.com/podcast/2019/02/24/ask-anything-nutrition-feb-17-2019/   If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

On February 23, members of the CMJ Masterpass joined me in a live Zoom meeting to ask me anything about nutrition, and here’s the full recording! We talked about lots and lots of things: 5-HTP versus tryptophan; unusually low appetite, my recommendations for glucose 6-phosphate dehydrogenase deficiency; choline and cognitive decline; how to gain muscle mass; side effects of vitamin B6; balancing thyroid hormones; which form of niacin to take for anti-aging (nicotinamide riboside, NR, versus nicotinamide mononucleotide, NMN); high cholesterol; measuring omega-3 and omega-6 fatty acid status; handling MSG sensitivity; sulforophane; unraveling an apparent urea cycle defect; harms of vitamin E for GSTP polymorphisms... …. and much more! If you’d like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral In this episode, you will find all of the following and more: 00:43 Cliff Notes 11:50 If my tryptophan is low, and I'm on a low-carb diet, would you recommend 5-HTP supplements or tryptophan supplements or both? 15:14 Should I be concerned about high HDL cholesterol in the context of low normal total cholesterol? 17:51 Is it a problem if my appetite is too low and I don’t seem to eat enough food, but everything about my health and well-being is great? 22:32 What should people with glucose-6-phosphate dehydrogenase deficiency be doing not just about glutathione, but about folate, vitamin K, fatty acids, and neurotransmitters? 36:53 Why do you recommend the Genova ION Profile instead of the NutrEval? 38:08 Could choline citrate, CDP-choline or alpha-GPC mitigate the risk of cognitive decline associated with anticholinergic use? 39:28 Do you have any recommendations on how to get enough calcium on a low-carb, no-dairy diet? 42:26 Should I manage my total cholesterol of 305 just for my doctor or should I be doing it for my own sake? If so, how should I do it? 54:14 During a workout, is there one type of sugar that is better at getting through the gut than any other type of sugar? 58:41 What food supplements and training programs are good for developing muscle mass? 01:03:02 Upcoming revisions to Testing Nutritional Status: The Ultimate Cheat Sheet, and which tests you could cut back on in order to save money. 01:05:36 Any thoughts on cod liver oil and Jigsaw Alaskan cod liver oil in particular? 01:08:26 Would you discuss the role that taurine might play in MTHFR? Adding taurine produced an immediate and dramatic improvement in my energy levels. 01:10:33 Tinnitus and nightmares as side effects from P5P supplementation. 01:15:33 What about the Jigsaw magnesium supplements? 01:16:18 If free T3 looks good, why is TSH still a little high? Why hasn't the T3 brought it down enough? 01:21:36 What to do about cataracts. 01:29:11 Do you have any gut experts you can recommend? 01:29:29 From your deep dive into nicotinamide riboside and NMN, do you think either is effective, and is one preferred over the other? Do you still recommend taking TMG with NR? 01:36:34 Do you know any differences in carbohydrate lipid metabolism in someone who has congenital adrenal hyperplasia? 01:38:18 Is it good insurance to supplement minerals that are less studied like chromium, molybdenum, and boron, or do you think it's unlikely to be beneficial? 01:39:35 If I have high LDL, do I need to know more about large fluffy particles versus small dense or should I just act on it now? 01:50:33 Do you know a potential reason that high LDL is associated with prostate cancer? What do you think of annatto tocotrienols? 01:52:24 Is it better to use red blood cell fatty acids like OmegaQuant offers instead of plasma fatty acids like Quest offers? 01:53:16 What could cause all of the following to be low at the same time: phenylalanine, tyrosine, tryptophan, glutamic acid, taurine, and threonine? 01:56:13 Can a B12 deficiency cause irreversible effects? 01:56:55 Can the B12 be near 2000 and still be a problem if the person has signs of B12 deficiency? 01:59:52 Suggestions for how to handle MSG sensitivity other than avoiding it. 02:04:00 Do you know of a good commercially available test for carnitine? 02:04:27 Is it true that we can’t absorb more than 1.5 grams of creatine at one time? 02:05:46 What could cause all of the following to be low at the same time: phenylalanine, tyrosine, tryptophan, glutamic acid, taurine, and threonine? The phenylalanine-to-tyrosine ratio is high, and the tryptophan-to-large non-polar amino acid ratio is low. 02:07:18 What are the pros and cons of boosting sulforaphane? 02:08:16 What could cause all of the following to be low at the same time: phenylalanine, tyrosine, tryptophan, glutamic acid, taurine, and threonine? 5-hydroxyindoleacetic acid is high. 02:14:28 Can you give any suggestions for increasing delta-6 desaturase activity? 02:16:50 What can be done nutritionally to specifically improve antiviral immunity? 02:18:55 Urea cycle question. High arginine, high ornithine, normal citrulline, very low aspartate, low glutamate, mid-range normal glutamine. Why does my urine stink, and why do I feel fatigued when I eat more protein? 02:30:34 I read that supplemental vitamin E has been shown to have a negative impact on individuals with this specific polymorphism by raising levels of pro-inflammatory cytokines in the blood. Do you have a view on this?

On February 17, members of the CMJ Masterpass joined me in a live Zoom meeting to ask me anything about nutrition, and here’s the full recording! We talked about lots and lots of things: using the Oura ring to measure HRV and optimize athletic performance and recovery, what to do in the context of diabetes if T3 doesn’t increase your heat production, whether keeping warm with clothing has health benefits if you can’t get your body temperature up, what to do about high morning glucose, how to get rid of heavy metals, how to repair bone, what vegans should do to get arachidonic acid levels up, zinc and copper supplementation, kale and spinach smoothies, blood donation when your transferrin saturation is high but your ferritin is low, dealing with a high resting heart rate, lots of questions on organic acid markers, how estrogen can mess up vitamin B6 markers even in men and when that means you should lower your protein intake, whether combining carbs and fat makes people fat, how many eggs to eat a day, how the nutritional needs of children are special, vitamin A toxicity in and out of pregnancy, creatine non-responders, intermittent fasting hurting sleep… This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” In this episode, you will find all of the following and more: This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral …. and much more! If you’d like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition 8:24 What to do, in the context of diabetes, if T3 supplementation does not increase heat production? 17:03 If you can't get your body temperature up to normal, will wearing more clothing to keep warm improve health? 19:40 What to do about elevated morning blood glucose in the mid 90s. 21:38 What are my thoughts on detoxing heavy metals? 23:36 What nutrients are needed to break down old, damaged bone and build new, healthy bone? 28:06 What should an ethical vegan with low delta-6 desaturase activity do to bring low arachidonic acid levels up to normal? 30:20 How to manage the zinc-to-copper ratio and what to do if zinc and copper are both low-normal when supplementing with 15 mg of zinc and 1 mg of copper. 34:20 How to lower a resting heart rate in the 80s or 90s. 37:00 Is a daily green smoothie with spinach or kale a risk because of thallium, goitrogens, oxalates, or other concerns? 39:20 For someone who is homozygous for the H63D allele of the iron- and hemochromatosis-related HFE gene, if ferritin is low but transferrin saturation is high, should they still donate blood? 48:20 For someone who is taking 45 mg of vitamin B6 as P5P but has xanthurenate, kynurenate, and quinolinate high in the urine as markers of vitamin B6 deficiency, and who is a man with high estrogen, what should they do? 56:18 What to do if taking biotin and yet beta-hydroxyisovalerate is elevated. 57:17 What to do if gamma-tocopherol levels are low-normal while taking 100 IU/d of alpha-tocopherol. 59:30 Does mixing carbohydrate with fat cause people to get fat because of the Randle cycle? (continued at 1:21:00) 1:03:35 Do children need less nutrients than adults because they have lower body weights, or do they need more nutrients than adults because they are growing faster? ( 1:07:12 What to do for a five-year-old who is unusually exhausted, and how to assess their nutritional needs. (Brief followup at 1:35:50) 1:09:30 Concerns about vitamin A intake during pregnancy. 1:12:24 How to use an Oura ring to monitor HRV and optimize recovery and performance. 1:15:40 What are "parent essential oils"? Should we get these instead of cold-water fish oils? Response to Brian Peskin’s theory. 1:21:00 More on whether the combination of carbs and fat makes people fat as a result of the Randle cycle. 1:29:00 Matt stone and the "overdeification" of vitamin A. Or, are there many people who are vitamin A deficient? Hypersensitivity reactions, fatty liver, overzealous use of cod liver oil, and other concerns. 1:35:50 How to deal with the fact that blood tests for nutritional status aren't adapted to children. 1:37:05 How much fatty fish to eat. 1:38:05 Nutritional strategies for glucose 6-phosphate dehydrogenase (G6PDH) deficiency. 1:42:58 If berberine lowers LDL-C and total-to-LDL-C but raises ApoB, what does this mean? 1:45:50 How to interpret the pattern of high citrate, low cis-aconitate, low glutamate, and high glutamine. (Followup at 1:53:05) 1:47:20 What do I think about Loren Cordain, his views on salt and dairy, and his opinion of Chris Kresser? 1:53:55 What to do about acne that gets worse with stress and better with cardio? 1:55:37 For MTHFD1, PEMT and MTHFR, should I be supplementing choline? 1:56:13 How to bring up low levels of arachidonic acid. 1:57:17 Using blood tests to determine whether you should increase your calcium intake. 1:57:45 Alex Leaf answers a question about creatine non-responders and methylation. 1:59:22 Could neurotransmitter levels be artificially low on the Genova ION panel if you fasted for 24 hours before having samples taken? 2:00:07 When to take tryptophan on a ketogenic diet. 2:00:52 When should you take creatine, if you don't have an MTHFR SNP? 2:01:30 My thoughts on PQQ and CoQ10 supplements. 2:02:02 What to do when high selenium levels won't come down, even if you've stopped supplementing. 2:02:24 Is four eggs a day too much? 2:03:05 Are low total omega-6 levels on the ION panel a cause for concern? 2:03:50 What to do about high arsenic. 2:04:24 What to do about fungal infection suggested by elevated D-arabinitol. 2:05:33 Migraines and twitching caused by coffee that responds to electrolytes. 2:09:55 What to do if signs and symptoms of zinc deficiency persist despite taking 75 mg zinc gluconate per day. 2:11:35 What to do if intermittent fasting beginning before 3:00 PM hurts sleep. 2:13:55 What to do about high-normal TSH and no diagnosis of a thyroid disease.    

Ladies, do you gain a lot of weight around your period? Here’s how daily supplementation with the right forms of magnesium and B6, as well as targeted use of a low-salt, high-potassium diet around your period with herbal diuretics and just the right dose of dark chocolate can help. Tune in to learn more! This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10 Here are links mentioned in this episode: Briana Theroux’s web site: https://brianatheroux.com Using the links below generates a small commission for me at no extra cost to you: Magnesium and B6 together (this could be taken twice a day): https://chrismasterjohnphd.com/amazon/mgandB6 Alternatively, you can take magnesium as glycinate or malate and B6 as pyridoxal 5’-phosphate (P5P) separately to yield 2-400 mg Mg and 40-50 mg P5P per day. If you like the taste, you could use this dandelion leaf and root tea: https://chrismasterjohnphd.com/amazon/dandelionleaftea If you don’t like the taste of the tea, you could use these capsules: https://chrismasterjohnphd.com/amazon/dandelionleafcapsules

Dana Laake and her special guest Anthony Thomas will discuss synergistic roles for bioactive B vitamins – methyl-B12, 5-MTHF, and P5P. Anthony Thomas, Ph.D., serves on Jarrow Formulas’ Scientific Panel. His primary research interests have focused on the influence of dietary and lifestyle factors on the pathogenesis of chronic cardiovascular/metabolic diseases including obesity, insulin resistance syndrome, and type 2 diabetes. He has authored/co-authored multiple peer reviewed scientific manuscripts and contributed his expertise in the fields of nutrition, obesity, and diabetes for a number of scientific journals.

まつもとゆきひろさんをゲストに迎えて、Ruby 2.0 などについて話しました。 Show Notes Ruby 20周年 Ruby 2.0.0-p0 released COOKPAD migrated to Ruby 1.9 Matz on Ruby 2.0 at Waza Ruby Implementers Meeting The Jon Orwant mug throwing incident at P5P meeting Perl5-6 Reunification Summit / Mug throwing