Podcasts about HFE

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Human Factors and Ergonomics (HFE) is the discipline that focuses on understanding and optimising interactions between humans and system components to enhance performance, safety, health and wellbeing. Human Factors Integration (HFI) is the process by which HFE knowledge, principles and methods are utilised throughout the system lifecycle to support the design of safe, usable and effective components. In this presentation, we outline the new Austroads Guidelined for Human Factors Integration in Road Transport (HFI-RT). The HFI-RT guideline provides road transport system stakeholders with information to support the consideration and application of HFE knowledge, principles and methods during the design, implementation and operation of road transport system components (e.g. vehicles and in-vehicle technologies, traffic control devices, signage, roads and roadsides, advertising, training and education programs, policies and procedures). During the presentation, we will provide an overview of the HFI-RT guideline and demonstrate it via a case study focused on driver distraction.

President Trump postponed strikes on Iranian power plants after saying negotiations were underway, but Iranian state media refuted those claims, triggering wild swings across asset classes. Markets now expect the Fed to hold rates steady, but HFE's Carl Weinberg makes the case for a hike. Plus, the airline bracing for oil prices to top $100 through 2027. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

David Osman of IRF is joined by Carl Weinberg the Founder, Managing Director and Chief Economist at High Frequency Economics. In this podcast Carl Weinberg assesses the latest data and discusses the risks to the outlook for the US economy, with particular reference to the impact on economic growth and consumer price inflation of a labour market that has reached the level of full employment. Carl then reviews the risks and the uncertain impact on the US economy and the rest of the world of the Trump Administration's tariff measures, given the erratic nature of the tariffs and their illegality. In addition, Carl discusses the conduct of US monetary policy and the outlook for US interest rates with reference to the prospective changes in the Chair of the Federal Reserve in May. Prior to founding High Frequency Economics in 1988, Carl Weinberg was the Chief Economist at Shearson Lehman Brothers. Carl has also worked at the Organisation for Economic Co-operation and Development (OECD) in Paris as a member of the economic forecasting unit. He currently teaches a graduate course in international finance at New York University. High Frequency Economics (HFE) provides sophisticated investors with insights on the global economy and financial markets. HFE produces unbiased and provocative analysis that assists the investment decisions of institutional investors.  

Join host Matt as he engages in a captivating conversation with his guest, American genetic counselor Erica Ramos. In this episode of Demystifying Genetics, Erica shares insights into her favorite gene, the HFE gene, associated with hereditary hemochromatosis. Their discussion delves into the evolution of understanding this condition and the importance of prevention and proactive health measures. The episode also explores the diverse roles of genetic counselors beyond clinical settings and Erica's journey, encompassing her experiences in direct-to-consumer testing and the startup world. Tune in for Erica's unique perspectives on genetic medicine, the future of preventive healthcare, and her entrepreneurial venture, Alcance Genomics. With engaging anecdotes and expert insights, this episode serves as an enlightening guide through the world of genetics, highlighting the profound impact of genetic counseling in both traditional and innovative spaces.

#202: Jack Herschend has served as Chairman, President and CEO of Herschend Family Entertainment and its portfolio of theme park, resorts, and aquariums.Today, Herschend Family Entertainment and its parent company Herschend Enterprises are considered the nation's largest family-owned themed attractions corporation in the US. Their team of more than 11,000 employees creates, develops, and operates entertainment, tourism, and hospitality properties that currently span 26 locations across the US and British Columbia.Herschend's roots date back to 1950 when the Herschend family founded their first attraction, a small cave tour in Branson, Mo., which later expanded into the famed Silver Dollar City®. Operating companies within Herschend Family Entertainment include Dollywood® Parks & Resorts, Silver Dollar City® Attractions, Harlem Globetrotters, Adventure Aquarium®, Newport Aquarium®, Kentucky Kingdom®, Vancouver Aquarium, and Wild Adventures®.Jack's intensity and deep caring for people shaped the company culture into what it is today. Jack attended Northwestern University as a wrestler and served as a Lieutenant in the Marine Corps before returning home to focus on the family business. He has a deep passion for personal service and giving and has actively served several Christian ministries including including Lives Under Construction Boys Ranch, Kids Across America and the National Institute of Marriage. In 1992, Jack founded The Gift of Green which has planted nearly 200,000 trees to counter deforestation due to development in the Missouri Ozarks.On the show he shares his story, growth of HFE, building a business, leadership, encouragement, failures, family, faith, marriage, and much more. Enjoy the show!

How are HDB BTO flats distributed in Singapore? Why the 99-year lease for public housing? Is housing affordability and BTO waiting time being addressed?In today's podcast, we invite Minister Indranee Rajah for a deep dive into public housing and housing policy updates in Singapore. We explore topics like public housing affordability amid rising HDB prices in Singapore's housing market, the new HDB BTO flat classification framework, and HDB flat eligibility (HFE) for first-time homebuyers seeking new BTO flats, like those at the newly completed Punggol Point Cove.#singapore #publichousing #dailyketchup Hosted on Acast. See acast.com/privacy for more information.

 Jill and Tom opened this week's show hitting briefly on a number of topics, including melting EV charging adapters, Jaguar's perplexing marketing reboot, the electric Dodge Charger Daytona, the high-mileage Ram 1500 HFE, and the consolidation of Infiniti and Nissan dealer stores. Still in the first segment, Jill recapped her time in the all-new Volkswagen ID. Buzz electric minivan. Jill found much to like, but noted that the van comes up short on estimated battery range, and that starting prices are high. In the second segment the hosts welcome Mark Gillies of Volkswagen to expand the ID. Buzz conversation. Mark shared a number of key details, including brand expectations that the van serve as a halo model, and not a high-volume offering. In the last segment Jill is subjected to Tom's “One Minute” quiz, in which she is challenged to answer questions in less than 60 seconds. 

In this week's episode we'll learn about iron, HFE hemochromatosis, and infections. In this large, population-based study, both high and low levels of plasma iron and transferrin saturation were associated with increased risks of infection. Then, we'll discuss how bispecific antibodies improve CAR T-cell response in B-cell malignancies. In-vitro and in-vivo data demonstrate enhanced therapeutic efficacy when a CD20-directed bispecific antibody is given in combination with CD19-directed CAR-T cells. Finally, we'll hear about determinants of outcome in NPM1-mutated AML. In a large series of patients with NPM1-mutated AML, investigators identified several variables beyond FLT3-ITD that adversely impacted outcomes. Featured Articles:Iron, hemochromatosis genotypes, and risk of infections: a cohort study of 142 188 general population individualsMolecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AMLCD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models

Dr Charlie Andrews speaks to Dr Jeremy Shearman about everything related to high iron levels (hyperferritinaemia).  We discuss how iron is regulated within the body, causes of raised iron levels, and then we dive into hereditary haemochromatosis - when to suspect, how to test, who to refer (and to whom!), and how the condition is managed.  Useful links to accompany this episode include:Welcome > Haemochromatosis: genetic iron overload disease (exeter.ac.uk)Haemochromatosis - British Liver TrustKey Learnings for Primary Care from the Ingest Podcast on HyperferritinaemiaKey LearningsUnderstanding Iron Regulation and FerritinFerritin is an acute-phase reactant and a marker of total body iron stores, but can be elevated in a range of conditions beyond iron overload, including inflammation, liver disease, and malignancy[2]. Understanding the physiological regulation of iron is crucial for interpreting ferritin results in context.Causes of HyperferritinaemiaRaised ferritin can result from: Hereditary haemochromatosis (genetic iron overload) Chronic inflammatory states (e.g., infection, autoimmune disease) Liver disease (e.g., alcoholic liver disease, hepatitis) Malignancy Metabolic syndrome It is important to consider these differential diagnoses when encountering an elevated ferritin[2].Hereditary Haemochromatosis: When to SuspectPrimary care clinicians should suspect hereditary haemochromatosis in patients with persistently raised ferritin and transferrin saturation, especially with suggestive symptoms (e.g., fatigue, arthralgia, diabetes, liver dysfunction) or family history[2]. Early recognition is key, as treatment can prevent complications.How to TestInitial investigations should include: Repeat ferritin measurement to confirm persistence Transferrin saturation (TSAT): TSAT >45% is suggestive of iron overload Liver function tests and assessment for other causes of raised ferritin[2] If hereditary haemochromatosis is suspected, genetic testing (HFE gene) should be considered.Who to Refer (and to Whom)Refer patients with confirmed iron overload (high ferritin and TSAT) or positive HFE mutation to hepatology or a relevant specialist for further assessment and management[2]. Referral is also warranted if there are signs of organ involvement (e.g., abnormal LFTs, diabetes, cardiac symptoms).Management PrinciplesFor hereditary haemochromatosis, mainstay of treatment is venesection (therapeutic phlebotomy) to reduce iron stores. Primary care plays a role in monitoring, supporting adherence, and managing comorbidities. For other causes, management is directed at the underlying condition.Practical Tips for Primary CareDo not ignore isolated raised ferritin-always interpret in clinical context. Exclude common secondary causes (infection, inflammation, liver disease) before pursuing rare diagnoses. Family screening may be appropriate in hereditary haemochromatosis cases[2]. Use local guidelines and specialist advice where available.Summary Table: Approach to Hyperferritinaemia in Primary CareStepAction/ConsiderationConfirm raised ferritinRepeat test... Chapters (00:00:00) - Ingesting: Iron overload and hereditary haemochromat(00:01:07) - Hemochromatosis 7, Regulation of iron stores(00:03:31) - What would you consider to be a high ferritin level?(00:04:57) - Ferritin and transfer and saturation(00:06:45) - High ferritin in liver, causes and treatment(00:09:05) - Hereditary Haemochromatosis in the UK(00:12:36) - Diagnosing hereditary haemochromatosis in primary care(00:15:58) - Hemochromatosis, C282Y homozygosity(00:19:26) - Cascade screening in haemochromatosis(00:23:07) - Hematology and hepatocellular cancer referral(00:25:30) - How to manage haemochromatosis in the UK?(00:32:27) - Hereditary haemochromatosis and iron overload(00:34:56) - Hemochromatosis(00:36:51) - Iron Overload

Medical device design often focuses solely on clinical users, overlooking a crucial group: maintenance personnel. This oversight can lead to inefficient servicing, increased downtime, and potential safety risks. In this episode, we explore the importance of applying humanfactors principles to medical device maintenance and servicing. Our expert guest, Avital Zik from Medtronic, discusses strategies for incorporating service personnel needs into device design, creating more user-friendly maintenance processes, and improving overall devicereliability. Rita Lin, Director of HFE at Kymanox, also offers her insight from past experiences working at the FDA and in industry.Learn how considering the full lifecycle of medical devices, from installation to repair, can enhance patient safety, reduce costs, and streamline healthcare operations. Join us as we uncover the hidden world of medical device maintenance and its impact on healthcare delivery.About the Factor:The Factor, your trusted podcast for the life sciences industry. Join us as we tackle the essential factors that drive successful commercial products. Our team interviews industry thought leaders to explore regulatory compliance, market trends, and innovation. Stay ahead in this dynamic industry. About Kymanox:Kymanox has proven, collaborative, end-to-end solutions that help bring life science products to the market – and keep them there. We are a global professional services organization that supports comprehensive drug development with integrated science, engineering, compliance (e.g., QA/RA), and technical project management.  Our work across small and large molecules, medical devices, and combination products affords us a wholly unique advantage. With our diverse team of experts, Kymanox helps clients navigate commercialization challenges that arise throughout a product's life cycle – from early development to post-market – with optimized safety, quality, efficacy, and accessibility. We strive to advance life science innovation through insightful solutions and collaboration…because patients deserve better. Kymanox was founded in 2004 and is headquartered in Morrisville, North Carolina USA. Kymanox is backed by WestView Capital Partners, a Boston-based growth equity firm. For more information, visit https://www.kymanox.com/.The Factor is edited and produced by Earfluence.

Today we present a poem by HFE, who once won Artist of the Month back in high school in faer silversmithing class. You can find more of faer stories on HFEpro.com.Read by Ta'kom Ironhoof, the Equine Charmer.thevoice.dog | Apple podcasts | Spotify | Google PodcastsIf you have a story you think would be a good fit, you can check out the requirements, fill out the submission template and get in touch with us.https://thevoice.dog/episode/the-devil-went-down-to-georgia-pride-by-hfe

In this episode, titled "Understanding FDA Perspectives on Medical Device Development" we embark on a comprehensive exploration of FDA perspectives alongside Greg Montalbano, Co-Founder of MIDI. Greg takes us on a comprehensive journey through FDA perspectives on Human Factors and Device Development, covering essential topics such as: - The FDA's concern regarding Human Factors Engineering and Usability - Expectations for medical device developers from the FDA - Real-world examples of medical device Human Factors Engineering relative to hazards, risks, and user-related causes This episode provides listeners with invaluable insights into the significance placed by both the FDA and MIDI on Usability Research and HFE quality processes. By understanding these crucial aspects, developers can ensure the creation of safe and effective medical devices that align with regulatory standards. Listen to MIDI's HFE MedTech Podcast Episode 2! Don't miss out on this enlightening discussion—tune in now to gain a comprehensive understanding of FDA perspectives and the importance of Usability Research in medical device development!

Dr. Privitera is Professor Emeritus of Psychiatry at University of Rochester Medical Center (URMC), and was Medical Director, Medical Faculty and Clinician Wellness Program 2015-2022, which worked on individual and organizational interventions to reduce clinician burnout. For the last 12 years he has taken a biopsychosocial approach to understand how the organization/system effects on clinicians and patients can have shared mechanisms which influence risk of burnout, latent medical error and conditions for workplace violence. He received a Patient Safety Award in 2018 from his malpractice carrier MCIC. The goal of this project was to deliver Human Factor-Based Leadership (HFBL) curriculum that integrates patient safety and clinician wellbeing efforts by leadership understanding of basic human factors and ergonomics (HFE) science applied in healthcare systems. This project helped leaders identify and reduce latent conditions in healthcare systems that contribute to error and clinician burnout. He was Chair 2015-2019, MSSNY Task Force on Physician Stress and Burnout and stepped down to focus upon making better known the connection of clinician wellbeing to patient wellbeing. He currently Co-Chairs Monroe County Medical Society Wellness Committee. He edited a multiauthored text Workplace Violence in Mental and General Healthcare Settings that received the 2012 Manfred Guttmacher Award for literature in forensic psychiatry from American Academy of Psychiatry and the Law (AAPL), a division of American Psychiatric Association. He was on the international Scientific Committee for Violence in the Health Sector 2014-2016 through Oud Consultancy. Dr. Privitera was a member of the Federation of State Medical Boards Task Force on physician burnout, which led to their 2018 national policy recommendations of limiting state board physician mental health questions to current impairment and not about past psychiatric history, to help encourage physicians to seek help and avoid stigma. He has presented on Human factor-Based Leadership at the International Symposium of Human Factors and Ergonomics (HFE) in Healthcare, IHI Patient Safety Congress, AHA Leadership Summit and 2022 Healthcare Burnout Symposiums in San Francisco and New York City. This HFE work led to invitations for AHA, AMA webinar presentations and to serve as a panel participant on 2022 World Patient Safety, Science and Technology Summit. Since July, 2022 he is Faculty of Institute for Healthcare Improvement in Boston, for Workplace Change Collaborative HRSA Grant, derived from the recently passed Lorna Breen Act to find ways to help the mental health and wellbeing of clinicians. He was a member, NIOSH Office for Total Worker Health® and the NIOSH Healthy Work Design and Well-Being Program: Healthy Work Design Council in 2020. He has written in publications of Physician Leadership Journal, The Joint Commission, American Hospital Association, National Patient Safety Foundation, Medscape, Journal of Hospital Administration and Journal of Legal Medicine on clinician burnout.Website: www.MichaelRPriviteraMD.com Link to claim CME credit: https://www.surveymonkey.com/r/3DXCFW3CME credit is available for up to 3 years after the stated release dateContact CEOD@bmhcc.org if you have any questions about claiming credit.

In this episode, Arneisha sat down with Mrs. Randiesia Fletcher and Mr. Herman Harris Jr for a discussion about The Urban Forest Project. The Urban Forest Project by HFE is a Housing Community with a focus on equity planning--building a culture of Sustainability that encompasses a Sustainable and Socially-Just planet. We discussed the mission behind The Urban Forest Project, Financial challenges POC face when starting a business and MUCH MORE. Follow Harris Fletcher Enterprises on Social Media

Robert (Bob) Bridger is a writer, consultant and teacher in Human Factors. He has a Ph.D in functional anatomy and biomechanics, an MSc in Ergonomics and a first degree in Psychology. His academic expertise is recognised in key areas of HFE including system safety and accident investigation, occupational biomechanics, work stress and Human Factors Integration.  He has moved comfortably between the world of academia and industry throughout his career and has published over 200 research papers, popular articles and official reports. He is Director of his own company, ‘Knowledge Sharing Events, Ltd' and helps organisations and universities to develop their expertise and programmes in Human Factors and Ergonomics. He is sole author of the textbook ‘Introduction to Human Factors and Ergonomics', now in its 4th edition and offering a comprehensive instructional support package including an Instructor's Manual, a Tutorial Guide and over 500 powerpoint slides. His newest book is: ‘A Guide to Active Working in the Modern Office: Homo Sedens in the 21st Century'. He also has Level 3 Fitness Instructor/Personal Trainer qualification. You can contact Dr Bridger via his website www.rsbridger.com. --- This podcast episode is sponsored by Fibion Inc. | The New Gold Standard for Sedentary Behaviour and Physical Activity Monitoring Learn more about Fibion: fibion.com/research --- Collect, store and manage SB and PA data easily and remotely - Discover new Fibion SENS Motion: https://sens.fibion.com/

Dr Robert Bridger (Pt 2) - 21st Century Guidance for active work in the office and at home Robert (Bob) Bridger is a writer, consultant and teacher in Human Factors. He has a Ph.D in functional anatomy and biomechanics, an MSc in Ergonomics and a first degree in Psychology. His academic expertise is recognised in key areas of HFE including system safety and accident investigation, occupational biomechanics, work stress and Human Factors Integration.  He has moved comfortably between the world of academia and industry throughout his career and has published over 200 research papers, popular articles and official reports. He is Director of his own company, ‘Knowledge Sharing Events, Ltd' and helps organisations and universities to develop their expertise and programmes in Human Factors and Ergonomics. He is sole author of the textbook ‘Introduction to Human Factors and Ergonomics', now in its 4th edition and offering a comprehensive instructional support package including an Instructor's Manual, a Tutorial Guide and over 500 powerpoint slides. His newest book is: ‘A Guide to Active Working in the Modern Office: Homo Sedens in the 21st Century'. He also has Level 3 Fitness Instructor/Personal Trainer qualification. You can contact Dr Bridger via his website www.rsbridger.com. --- This podcast episode is sponsored by Fibion Inc. | The New Gold Standard for Sedentary Behaviour and Physical Activity Monitoring Learn more about Fibion: fibion.com/research ---

In this episode we explore the tragic failure in human factors engineering on the Boeing 737 MAX and why early incorporation of the user's needs and limitations is key to developing better, safer products. Dr. Mica Endsley, former Chief Scientist of the Air Force and founder of SA Technologies, joins us to discuss Human Factors Engineering and what we can learn from the 737 MAX tragedies.  Human Factors & Ergonomics Society: www.hfes.org

Episode 58: Transaminitis.  Elevated aminotransferases can be caused by intrahepatic and extrahepatic causes, Dr Martinez and Dr Civelli explain the workup of transaminitis, distribution of Chantix was stopped by Pfizer, smoking cessation updates Introduction: Smoking Cessation UpdatesBy Hector Arreaza, MD, Valeri Civelli, and Yosbel Martinez, MD On June 25, 2021, Pfizer stopped distribution of some badges of Chantix(r) after high levels of the carcinogen N-nitroso-di-methyl-amine (NDMA) were found in some lots of the pills. “Pfizer told Reuters the distribution pause was ordered out of abundance of caution while further testing is conducted.”The FDA approved Varenicline in 2006, and there is evidence that Chantix is the most effective anti-smoking medication.USPSTF Grade A recommendations:1. All adults should be asked about their tobacco use. Then, if determined to be smokers or tobacco users, advise them to quit, and provide behavioral interventions and FDA-approved medications for cessation. This applies to all adults who are not pregnant and use tobacco.2. All pregnant patients should be asked about their tobacco use, advised to quit using tobacco, and offer behavioral interventions for cessation. USPSTF Grade I (I stands for “I don't know”):1. The USPSTF does not endorse or discourages the use of pharmacotherapy for smoking cessation in pregnant patients because there is insufficient evidence.2. E-cigarettes have insufficient evidence to be recommended as an effective way to stop smoking in adults. This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home.___________________________Transaminitis. By Yosbel Martinez, MDTransaminitis (Also known as Elevated Aminotransferases). “itis” normally means inflammation in medical terms, and for that reason transaminitis is not etymologically correct, but it's easy to use and everyone understands what it means. What are aminotransferases?Aminotransferases are intracellular enzymes are sensitive indicator of liver cell injury (necrosis vs inflammation) ALT (alanine aminotransferase) more specific measure of liver injury because AST (aspartate aminotransferase) also found in striate muscle, heart, brain, kidney and Red and white blood cells.-There is poor correlation between degree of liver cell damage and level of aminotransferases. General Approach of Chronic Transaminitis Chronic > 6 months (Often asymptomatic patient)Initial evaluation for most common liver conditions.-Drugs (herbal or recreational drugs) or medications (acetaminophen, INH, amiodarone, statins)-Hepatitis A, B, C-Alcohol Hepatitis AST/ALT ratio above 2:1-Fatty Liver AST/ALT < 1, RUQ Ultrasound- Hemochromatosis Iron/TIBC > 45% Hereditary hemochromatosis is an autosomal recessive disorder that disrupts the body's regulation of iron. It is the most common genetic disease in whites. Men have a higher risk of iron-overload disease compared with women. Hemochromatosis symptoms are absent in the early stages. If present, symptoms may include weakness, lethargy, arthralgias, and impotence. Later manifestations include arthralgias, osteoporosis, cirrhosis, hepatocellular cancer, cardiomyopathy, dysrhythmia, diabetes mellitus, and hypogonadism. Diagnosis requires confirmation of increased serum ferritin levels and transferrin saturation, with or without symptoms. Treatment of hereditary hemochromatosis requires phlebotomy, and the frequency is guided by serial measurements of serum ferritin levels and transferrin saturation. Dietary modification is generally unnecessary. Screen: Testing should be performed in first-degree relatives of patients with classical HFE-related hemochromatosis, those with evidence of active liver disease, and patients with abnormal iron study results. Screening for hepatocellular carcinoma is reserved for those with hereditary hemochromatosis and cirrhosis. Statins: Statins are very important in prevention of treatment of cardiovascular disease. They are safe.“The risk of hepatic injury caused by statins is estimated to be about 1 percent, similar to that of patients taking a placebo.”Patients with transaminase levels no more than three times the upper limit of normal can continue taking statins; often the elevations will resolve spontaneously. Coexisting elevations of transaminase levels from nonalcoholic fatty liver disease and stable hepatitis B and C viral infections are not contraindications to statin use Dosing: Hepatic Impairment: AdultContraindicated in active liver disease or in patients with unexplained persistent elevations of serum transaminases. Further evaluations to Determine likely source-Hepatic source (less common liver conditions)-Autoimmune Hepatitis (women, SPEP, ANA, ASMA)-Wilson disease (ceruloplasmin, slip lamp exam for Kayser- Fleischer rings)-Alfa 1- antitrypsin deficiency (emphysema out of proportion, obtain AA-1 level)-Other viral Hepatitis D, E, CMV, EBV, HSV,VZV. Non-Hepatic source.-Muscle disorder (CK, aldolase)-Thyroid disease (FT4, TSH)-Celiac/IBD (IgA anti-tissue transglutaminase, Calprotectin,CRP, P-ANCA, MRCP/ERCP.-Adrenal insufficiency (8 am cortisol level and plasma ACTH)-Anorexia nervosa (Psychiatric evaluation, BMI, electrolytes and Echo or TTE) Final step of evaluation.Liver biopsy (for diagnostic, staging and grading of liver disease)Now we conclude our episode number 58 “Transaminitis”. Dr Martinez and Dr Civelli explained what to do when we find elevated aminotransferases. Remember you can have intra-hepatic and extra-hepatic causes. If you cannot determine what's causing transaminitis, you may need to ask for a liver biopsy.  Even without trying, every night you go to bed being a little wiser.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email RBresidency@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created with educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Yosbel Martinez, and Valerie Civelli. Audio edition: Suraj Amrutia. See you next week!_____________________References:Pfizer Halts Distribution of Stop-Smoking Pill Chantix, WebMD, webmd.com, accessed on Jul 6, 2021. https://www.webmd.com/smoking-cessation/news/20210625/chantix-distribution-halted-pfizer. Tobacco Smoking Cessation in Adults, Including Pregnant Persons: Interventions, United States Preventive Services Taskforce, uspreventiveservicestaskforce.org, accessed on Jul 6, 2021. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions Uworld Boards Family Medicine Qbank.Harrison's Manual of Medicine 20th Edition.Pocket Medicine 7th Edition by Marc S. Sabatine.      

Friends of the show The Mae cousins and former HFE and Sea world executive Joel Manby from The Podcast "The Dollywood Reporter" explore the history and many variations of Walt Disney's (Formerly General Electric's) Carousel of progress. Enjoy learning the finest of detail of each scene, the changes through the decades and the origins of the idea from the never built, but fully realized Edison Square from Disneyland in the 1950s Photo courtesy of www.disnerland.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Herschend Family Entertainment (HFE) -- the largest family-owned theme park corporation in the United States that Peter Herschend co-founded along with his brother, Jack -- includes a number of theme parks in the Southeastern United States including Silver Dollar City in Branson, Missouri; Dollywood in Pigeon Forge, Tennessee; and Stone Mountain in Atlanta. In all these venues, employees are treated as family, and the company cares for the whole person, giving each one respect as an individual. Story after story, including an “Undercover Boss” CBS Television episode starring then-CEO of HFE, Joe Manby, shows how the spiritually-fed values of a company apply to everyone on board from what many would consider the least to the greatest.  There is no distinction.

- Detroit Diesel Making EV System for Daimler Trucks- Stellantis CEO Voices Support for Chrysler Brand- U.S. ITC Rules Against SK Innovation- Is Tesla's Sales Model That Different from a Dealer?- Rivian Plans European Plant?- Auto Group Says EU Needs 1 Million Charging Stations- Are These the Ultimate Off-Roaders?- Toyota Announces New BEVs for the U.S.- Ram Adds HFE EcoDiesel to Pickup Lineup- Ford Launches Online Used Car Platform

- Detroit Diesel Making EV System for Daimler Trucks - Stellantis CEO Voices Support for Chrysler Brand - U.S. ITC Rules Against SK Innovation - Is Tesla's Sales Model That Different from a Dealer? - Rivian Plans European Plant? - Auto Group Says EU Needs 1 Million Charging Stations - Are These the Ultimate Off-Roaders? - Toyota Announces New BEVs for the U.S. - Ram Adds HFE EcoDiesel to Pickup Lineup - Ford Launches Online Used Car Platform

The much anticipated Series 3 podcast is now available! Join MIDI's principal, Gregory Montalbano, in this series as he shares his deep understanding of the importance, requirements, and methods of Human Factors Engineering (HFE) and Usability Research during the design innovation process of medical devices. This new series will cover the role of human factors engineering in medical device development and explore specific methods, techniques, and examples of implementation. We begin with Episode 1 of the Series, Human Factors & User Interface Design for Medical Devices: The Overview. In this episode, Greg kicks-off the series with an executive-level discussion of the importance and benefits of MIDI's Human Factors & Usability Research quality process as related to medical device development programs. Greg continues his deep dive into why HFE and Usability Research are critical elements and what is expected by the FDA. Additionally, we discuss HFE and Usability considerations' specifics involving the three major development components of a medical device: the Device Users, Device Use Environments, and Device User Interfaces. In the remainder of this series, Greg affords the listeners full detailed access to his deep and diverse knowledge within specific verticals of Human Factors Engineering related to Medical Devices.

This episode comes to you straight from the casino floor of the Bellagio in Las Vegas, where we discuss new beginnings and revenge, specifically in Ocean's Eleven, The Count of Monte Cristo (2002), and Captain America: Civil War.You can discuss this episode with us in our amazing Discord (the real Good Place): just visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

In this episode, we ask a plethora of "Would You Rather?" questions, all with a pop culture twist. List of questions.You can discuss this episode with us in our amazing Discord (the real Good Place): just visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

SPOILERS for the Good Place finale ahead!This episode comes to you straight from The Good Place. We discuss the farewell episodes of television masterpiece The Good Place and why endings are important, valuable, necessary, and good. "Picture a wave . . ."You can discuss this episode with us in our amazing Discord (the real Good Place): just visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

This episode comes to you straight from a mythical menagerie! We bring you all the best history from our favorite mythological creatures: mermaids, dragons, phoenixes, and unicorns!You can discuss this episode with us in our amazing Discord: visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Hello from Elsewhere is 2 years old this month! To celebrate, we answer a flood of listener questions, like what inspired the podcast, what our favorite episodes are, and whether a straw has one hole or two. Discuss this episode with us in our amazing Discord: just visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Question: Why would ferritin be extremely high when transferrin saturation is low? Ferritin as a potential indicator of iron overload should not be anywhere near the level that was set to try to rule in biopsy provable hemochromatosis that is just a profoundly negligent approach to setting the range for ferritin. Now, I think part of what has stopped, you know— This mostly is a problem of the binary diagnostic mindset of conventional medicine. So, I'm not saying that this mindset is not useful. It is tremendously useful, but too many people confuse it for a reality when in fact it is a reality distortion filter meant to more efficiently triage people through various treatments or nontreatments. It may be inflammation as you very well tried to feather out. And if it's not that, it's probably oxidative stress. So, I’m not gonna say that’s the only other thing it could be. And for the record, you cannot rule out hemochromatosis genetics with 23andMe or any other genetic test by anyone because there are a small percentage of hemochromatosis genetics that are not in the HFE genes and no one has a panel for them. And so, it’s improbable that it’s hemochromatosis based on 23andMe. You can’t rule it out, but I would say it’s probably not hemochromatosis because his iron is low. And so, you know, I'm highly suspicious of oxidative stress, which also upregulates ferritin. If you have Testing Nutritional Status: The Ultimate Cheat Sheet, I would measure everything in the oxidative stress section. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations  DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

On June 17, 2020, the Canadian Hemochromatosis Society presented its first online information session in its Membership Lecture Series. We were honoured to have Prof. Pierre Brissot join us live from Rennes, France, to provide us with an updated view on the definition, diagnosis and treatment for hemochromatosis in 2020.Pierre Brissot is a Professor Emeritus of Medicine; Member of the French National Academy of Medicine; Past-President of the International BioIron Society; Founder or Co-founder of FFAMH (Fédération Française des Associations de Malades de l’Hémochromatose), EFAPH (European Federation of Associations of Patients with Haemochromatosis), and HI (Haemochromatosis International).In this second episode of the lecture, Prof. Brissot takes the listener through the diagnostic aspects of HFE and non-HFE hemochromatosis. To view the visuals Prof. Brissot references in this podcast, please visit https://www.toomuchiron.ca/video. We acknowledge the financial support of the Province of British Columbia in the production of this podcast. Support the show (https://www.toomuchiron.ca/donate/)

This episode comes to you straight from Lake Geneva, Switzerland, in the middle of a rainstorm! We bring you all the best trivia from the lives of pop culture's most valuable friendships: Mary Shelley and friends, J.R.R. Tolkien and C.S. Lewis, and George Lucas and Steven Spielberg. Plus, we discuss what creative people we'd invite over for dinner, and we end the episode with a BIG PATREON ANNOUNCEMENT!You can discuss this episode with us in our amazing Discord: visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org . Article from The Atlantic.

Chris Herschend is a third-generation shareholder and Chairman of Missouri-based Herschend Enterprises (https://herschendenterprises.com/), the largest family (https://www.hfecorp.com/)-owned themed attractions company in the US. HFE properties span 26 locations and 10 states, employing over 10,000 people who collectively host over 13 million guests annually at properties including Silver Dollar City, Dollywood and the world-famous Harlem Globetrotters (https://www.harlemglobetrotters.com/). Standout Quotes: * "That's not your board members' primary role; to be experts on your business, they're really there to be a resource for you, a check for you..they also provide a level of protection" – Chris Herschend * "I hear a lot of family businesses that do not have shareholder agreements in place, and that's a mandatory first step, you've got to have a shareholder agreement before you do anything else" – Chris Herschend * "You can't trust somebody if you don't know them; you can't know them if you never see them" – Chris Herschend * "You'd be amazed at what millionaires would do for a $250 plane ticket" – Chris Herschend * "It's not about you and you are not your own" – Chris Herschend Key Takeaways: * Humility and Accountability define the principle behind the business model of a majority independent board for their family-owned company. * The primary role of your board members is not to be experts in your business, they are there to be a resource, a check, and for protection * Humility of an owner who wants a true board is so attractive to high-quality board members and business thinkers that they want to be a part of that * You need to know where you are in the generational business cycle * The primary role of the board is to be truth-tellers * One of the hardest things you have to do as a larger family is to define 'Family' * The simplest most important thing done in their family business is "Gathering" * Chris emphasizes to his kids that their job is to steward the family business Episode Timeline: * [00:49] An Introduction to Chris Herschend * [01:26] The mission of Herschend Enterprises is to create memories worth repeating; Chris shares the history of the company * [07:26] The day to day operations of the business as a theme park * [10:10] Chris gives a detailed description of the governing structure of the family business * [13:30] Reasons behind the business model of a majority independent board for a family-owned company. * [21:33] The family is constantly around the business but rarely in the business. * [26:03] Chris describes his role in the family business * [35:40] The different phases or eras in handling the wealth of the family business * [48:50] Are there any key resources that your family has invested in to get to where you are today? * [56:27] A letter from Chris to his kids *For more episodes go to * BusinessOfFamily.net (https://www.businessoffamily.net/) Sign up for The Business of Family Newsletter at https://www.businessoffamily.net/newsletter (https://www.businessoffamily.net/newsletter) Follow Mike on Twitter @MikeBoyd (https://twitter.com/MikeBoyd) If you feel it's appropriate, I'd so appreciate you taking 30 seconds to Leave a Review on iTunes (http://getpodcast.reviews/id/1525326745), I receive a notification of each review. Thank you! Special Guest: Chris Herschend.

Brandon Hayden joined me today on this episode of the Hunt Fish Eat Podcast. Brandon was the Chef De Partie at Justus Drug store in Smithville, MO. Justus Drug Store is a farm to table restaurant focused on using ingredients that come from a 100 mile radius of the restaurant. I met Brandon when we were both mentoring a dove hunt for the awesome ladies of WildHERness. Brandon whipped up some dove breast and polenta with a tomato gravy all on the burner from a turkey fryer and a park bench at glen elder state park. It was a delicious meal and I was really excited to get to sit down with someone that has a very technical cooking background.In this episode we discussed how you should treat your wild game when harvesting it, some good concepts to have about cooking and especially wild game, also we discussed some bomb proof cooking methods.Brandon will be joining me for some hunting adventures this fall, so I am sure we will hear more from him! Below are some of the links to HFE content and the things that we talked about today!Links:Patreon:https://www.patreon.com/HuntFishEatInstagram:https://www.instagram.com/_hunt_fish_eat_/?hl=enFacebook:https://www.facebook.com/hntfsheatYoutube:https://youtube.com/channel/UCsngsHDDYKZny29ix3ekbqgClay Shooting Apparelhttps://clayshootingapparel.com/product/cool-trap-shooting-hats-richardson/Walton's Inc Food Thermometerhttps://www.waltonsinc.com/waltons-orange-long-digital-thermometerSous Vide Machinehttps://www.waltonsinc.com/weston-sous-vide-immersionhttps://www.waltonsinc.com/hbc-immersion-circulatorSupport the show (https://www.patreon.com/HuntFishEat)

This episode comes to you straight from a mad scientist's laboratory, where Valerie and Casey explore the themes of Mary Shelley's Frankenstein in three modern films: Jurassic Park (1993), The Prestige (2006), and Avengers: Age of Ultron (2015) all include obsessive characters who take their scientific creations too far. Plus, Valerie claims the Iron Man suit is a monster, and Casey accepts his death at the (small) hands of a T-rex.You can discuss this episode with us in our amazing Discord: visit www.patreon.com/hellofromelsewhere to join! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Today is October15th, 2020 and it's an all new Human Factors Cast hosted by Nick Roome and Blake Arnsdorff. Banter: Star Wars Squadrons: https://amzn.to/3nY0JlF Call of Duty: Black Ops Cold War: https://amzn.to/343KFXi Playstation 5 Console: https://amzn.to/3k4Cm38 Human Factors News: All The Ways The F-35 Tried To Kill Its Pilot Prior To Eglin AFB Crash https://www.thedrive.com/the-war-zone/36970/all-the-ways-the-f-35-tried-to-kill-its-pilot-prior-to-eglin-afb-crash It Came from... Can I use an HFE journal in my portfolio? Follow Nick: https://www.twitter.com/Nick_Roome Follow Blake: https://www.twitter.com/DontPanicUX Design Lab UX Courses WIth Blake: http://share.trydesignlab.com/hfcast Join us on Slack: https://bit.ly/2KDael9 Human Factors Cast Merchandise Store: https://shop.spreadshirt.com/human-factors-cast/ Support us on Patreon: https://www.patreon.com/humanfactorscast Follow us on LinkedIn: https://www.linkedin.com/company/humanfactorscast Follow us on Twitter: http://www.twitter.com/HFactorsPodcast Follow us on Facebook: https://www.facebook.com/HumanFactorsCast Follow us on Soundcloud: https://www.soundcloud.com/HumanFactorsCast Follow us on YouTube: https://www.youtube.com/HumanFactorsCast Our official website: https://www.humanfactorscast.com Our Gear: Recorded with Audio-Technica ATR2100-USB: https://amzn.to/3gRTlnr Microphone stand: https://amzn.to/3iUC8LM Headphones: https://amzn.to/301mGoB Audio software: https://www.audacityteam.org/download/ Webcam (For conferencing): https://amzn.to/2DuJ9Tj Logo design by E Graphics LLC: https://egraphicsllc.com/ Take a deeper look into the human element in our ever changing digital world. Human Factors Cast is a podcast that investigates the sciences of psychology, engineering, biomechanics, industrial design, physiology and anthropometry and how it affects our interaction with technology. As an online source for human factors, psychology, and design news, Human Factors Cast is your essential resource for new, exciting stories in the field. Disclaimer: Human Factors Cast may earn an affiliate commission when you buy through the links here.

Robert (Bob) Bridger is a writer, consultant and teacher in Human Factors. He has a Ph.D in functional anatomy and biomechanics, an MSc in Ergonomics and a first degree in Psychology. His academic expertise is recognised in key areas of HFE including system safety and accident investigation, occupational biomechanics, work stress and Human Factors Integration. He has moved comfortably between the world of academia and industry throughout his career and has published over 200 research papers, popular articles and official reports. He is Director of his own company, ‘Knowledge Sharing Events, Ltd’ and helps organisations and universities to develop their expertise and programmes in Human Factors and Ergonomics.He is sole author of the textbook ‘Introduction to Human Factors and Ergonomics', now in its 4th edition and offering a comprehensive instructional support package including an Instructor’s Manual, a Tutorial Guide and over 500 powerpoint slides. His newest book is: ‘A Guide to Active Working in the Modern Office: Homo Sedens in the 21st Century’. He also has Level 3 Fitness Instructor/Personal Trainer qualification. You can contact Dr Bridger via his website www.rsbridger.com.---This podcast episode is sponsored by Fibion Inc. | The New Gold Standard for Sedentary Behaviour and Physical Activity MonitoringLearn more about Fibion: fibion.com/research---

The RSB Show 10-7-20 - Track and Trace, Health passports, Jason Ameling, HFE, Ty Bollinger, TTAV by Robert Scott Bell

Robert (Bob) Bridger is a writer, consultant and teacher in Human Factors. He has a Ph.D in functional anatomy and biomechanics, an MSc in Ergonomics and a first degree in Psychology. His academic expertise is recognised in key areas of HFE including system safety and accident investigation, occupational biomechanics, work stress and Human Factors Integration. He has moved comfortably between the world of academia and industry throughout his career and has published over 200 research papers, popular articles and official reports. He is Director of his own company, ‘Knowledge Sharing Events, Ltd’ and helps organisations and universities to develop their expertise and programmes in Human Factors and Ergonomics.He is sole author of the textbook ‘Introduction to Human Factors and Ergonomics', now in its 4th edition and offering a comprehensive instructional support package including an Instructor’s Manual, a Tutorial Guide and over 500 powerpoint slides. His newest book is: ‘A Guide to Active Working in the Modern Office: Homo Sedens in the 21st Century’. He also has Level 3 Fitness Instructor/Personal Trainer qualification. You can contact Dr Bridger via his website www.rsbridger.com.---This podcast episode is sponsored by Fibion Inc. | The New Gold Standard for Sedentary Behaviour and Physical Activity MonitoringLearn more about Fibion: fibion.com/research---

This episode comes to you from on board the NSEA Protector! In this episode, we explore a sub-subgenre of comedy films: actors playing actors but nobody knows they're actors. Specifically, we compare and contrast Three Amigos! (1986), A Bug's Life (1998), and Galaxy Quest (1999). Plus, Valerie pitches an autobiographical film with Mandy Moore singing in the New Mexican wilderness.You can join our Discord by visiting www.patreon.com/hellofromelsewhere ! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

This episode comes to you straight from Anvil Studios in March 1977, where the London Symphony Orchestra is about to record the score for Star Wars. In this episode, we explore the emotional resonance of the music of John Williams, from Jaws to Star Wars to Harry Potter! Plus, we debate whether John Williams wears tuxedo pajamas. You can join our Discord by visiting www.patreon.com/hellofromelsewhere ! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org . Our John Williams playlist: https://www.patreon.com/posts/41404907

Broadcasting from the Pemberley garden, we discuss the many film adaptations of Jane Austen's novels, from Sense & Sensibility (1995) to Pride & Prejudice (2005) to Emma (2020). Plus, we talk Pride & Prejudice & Zombies, Clueless, and the Lizzie Bennet Diaries.You can join our Discord by visiting www.patreon.com/hellofromelsewhere ! Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org . Article mentioned in this episode: www.theringer.com/movies/2020/7/17/21327905/clueless-jane-austen-adaptations

Broadcasting from the McCallister family home in the suburbs of Chicago, we celebrate Valerie turning 30! To commemorate, we discuss our favorite movie EVERY YEAR since 1990: from romantic comedies to animated films to science fiction epics, we cover it all!   You can become an official Human of Elsewhere by visiting www.patreon.com/hellofromelsewhere . Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Broadcasting from a greeting card company in Los Angeles, we analyze the manic pixie dream girl trope in 500 Days of Summer. Plus, we explore Elizabethtown, Casey dreams of riding Appa over Middle-Earth, and Valerie wants to go on a knitting spree with Molly Weasley! You can become an official Human of Elsewhere by visiting www.patreon.com/hellofromelsewhere . Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Broadcasting from a wretched hive of scum and villainy--in a galaxy far, far away--we explore the symbolism of masks in both The Mandalorian and The Rise of Skywalker. Plus, we discuss why Ben Solo's skin is so luminous, we wonder whether General Hux is jealous of Kylo Ren's mask, and Valerie acts like the Mouth of Sauron again! You can become an official Human of Elsewhere by visiting www.patreon.com/hellofromelsewhere . Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Broadcasting from the biggest wave off the coast of California, we dive into the fascinating history of the (somewhat) forgotten genre of beach party movies--from Gidget to Teen Beach Movie, and every music-filled, surf-crazed film in between. Plus, we discuss Spielberg's Jaws, we dream of shopping for sweaters with Rian Johnson, and we create our own beach movie mad libs! You can become an official Human of Elsewhere by visiting www.patreon.com/hellofromelsewhere . Check out our HFE and Happy Beeps merch at www.teespring.com/stores/hello-from-elsewhere ! Hello from Elsewhere is a proud member of WBNE. For more great podcasts, visit www.wbne.org .

Dear Listener,Today's gonna be a good day and here's why: because today is all about the Queen herself, Dame Julie Andrews! Valerie from the podcast "Hello From Elsewhere" joins us to talk her humble beginnings and rise to stardom. Julie Andrews is one classy lady, and we make sure to mention that at least 73 times in this episode.A special THANK YOU to Valerie for being on our show! Make sure to check out the WBNE website for all the links to Hello From Elsewhere and and follow HFE on Instagram and Twitter!Sincerely, UsSincerely, Us is a proud member of WBNE! Check out the WBNE website to find information about all the shows on the network and to purchase a SUPER SHOUTOUT!Become a patron of Sincerely, Us on Patreon Follow us on social media!  Join our Facebook Group! http://bit.ly/sincerelyfbSincerely, Us Podcast:  @sincerelyuspod on Instagram & Twitter  Becca: @beccaeddows on Instagram & Twitter Iny: @_inymeeny on Instagram & Twitter Our graphics are by Vashaun Brandon of Graphite: Instagram & Website 

Question: For someone who is homozygous for the H63D allele of the iron- and hemochromatosis-related HFE gene, if ferritin is low but transferrin saturation is high, should they still donate blood?   H63D is one of the genes that predisposes to hemochromatosis, a condition of iron overload. Most clinicians who work in this area do not consider the H63D allele to be a concern because it's less severe. With that said, most people who are progressive on the iron research front do believe it's a concern. There is literature showing that people can get clinical hemochromatosis from it and you don't have to get clinically hemochromatosis to be worried about iron overload.     My opinion on this is going to be different than someone who is an expert clinician, but is not immersing themselves deeply in the physiological literature about how this works.   I don't have the skills that they have in triaging and filtering who’s ideal for what treatment and looking at large numbers of people that do one or another treatment and knowing intuitively what happens in those — but what I do have is I have immersed myself very deeply in the physiology.    So the way that I look at this is as follows: iron saturation is an estimate of your transferrin saturation. It's a cheaper way to estimate it than to actually measure transferrin saturation, so it's much more common to get iron saturation.   But let's assume that we're talking about actual transferrin saturation or that iron saturation is a good metric of it. That's your short-term iron storage. Ferritin is your long-term iron storage. The defect in the H63D allele, same for the C282Y allele of the HFE gene, the two moderate and severe hemochromatosis alleles. Allele is a variant of the gene.   In normal physiology what happens is transferrin acts as a gauge of your iron status. The normal physiological levels are between 30 and 40 percent. Now being 41 percent doesn't mean you have a disease, we're not talking about diagnosis here, we're talking about understanding the physiology.   Mechanistically this is designed so that as you go from 30 to 40 percent and especially as you go over 40 percent that communicates the signal to a hormonal system that says you have more iron than you need. So you ramp down iron absorption and you ramp up ferritin. Why do you ramp up ferritin? Because you have more than you need in your short-term storage, so that's when you put it into your long-term storage. Also, because ferritin is a protective response that prevents you from having free iron.   Free iron is bad because it feeds pathogens and it makes infections worse. Free iron is bad because it causes oxidative stress and causes wear and damage on your tissues. And so to avoid free iron you ramp up ferritin while you take down your absorption from food at the same time.   And now is that a problem at all?  You could debate that, but if you're just talking, if you're not talking about diagnosis and you're talking about wellness, and you're talking about health management then… What I would want to do myself in that situation is I would first of all not let the ferritin go under 20, and if it's going near there I would be getting a CBC to make sure I'm not making myself anemic.    And so I would not stop donating blood just because the ferritin is going down 60, 50, 40, I would consider it a gray area, it would be my preference to focus on the transferrin saturation and get it consistently under 40%. You get the pinprick to look at your serum iron levels, they're not going to let you donate blood if you're actually in the danger zone of anemia.   So I would get the CBC to be proactive about it.   This Q&A can also be found as part of a much longer episode, here: https://chrismasterjohnphd.com/podcast/2019/02/24/ask-anything-nutrition-feb-17-2019/   If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

In this #Power2Think podcast episode, Dr. Manghu Singh, MD, DMRC and Mr. Sunil Jain, CEO, HFE, discuss the importance of #solar energy for Delhi Metro and the challenges such a project poses.

Dr. TS Panwar, Climate Change and Energy Program, WWF - India and Mr. Karl Cardozo, Chief Manager, CEO's Office, HFE, discuss the impact of climate change and possible measures against it in this #Power2Think podcast episode.

Introducing the first episode of #Power2Think Podcast with Chintan Shah, Director (technical), IREDA and Naveen Khandelwal, Chief Investment Officer, HFE. An enriching discussion, the two shared their opinions and announced the latest technology. Listen to know all about the advantages of emerging renewable energy trends in India – floating solar and hybrid renewable energy plants.

On February 17, members of the CMJ Masterpass joined me in a live Zoom meeting to ask me anything about nutrition, and here’s the full recording! We talked about lots and lots of things: using the Oura ring to measure HRV and optimize athletic performance and recovery, what to do in the context of diabetes if T3 doesn’t increase your heat production, whether keeping warm with clothing has health benefits if you can’t get your body temperature up, what to do about high morning glucose, how to get rid of heavy metals, how to repair bone, what vegans should do to get arachidonic acid levels up, zinc and copper supplementation, kale and spinach smoothies, blood donation when your transferrin saturation is high but your ferritin is low, dealing with a high resting heart rate, lots of questions on organic acid markers, how estrogen can mess up vitamin B6 markers even in men and when that means you should lower your protein intake, whether combining carbs and fat makes people fat, how many eggs to eat a day, how the nutritional needs of children are special, vitamin A toxicity in and out of pregnancy, creatine non-responders, intermittent fasting hurting sleep… This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” In this episode, you will find all of the following and more: This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral …. and much more! If you’d like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition 8:24 What to do, in the context of diabetes, if T3 supplementation does not increase heat production? 17:03 If you can't get your body temperature up to normal, will wearing more clothing to keep warm improve health? 19:40 What to do about elevated morning blood glucose in the mid 90s. 21:38 What are my thoughts on detoxing heavy metals? 23:36 What nutrients are needed to break down old, damaged bone and build new, healthy bone? 28:06 What should an ethical vegan with low delta-6 desaturase activity do to bring low arachidonic acid levels up to normal? 30:20 How to manage the zinc-to-copper ratio and what to do if zinc and copper are both low-normal when supplementing with 15 mg of zinc and 1 mg of copper. 34:20 How to lower a resting heart rate in the 80s or 90s. 37:00 Is a daily green smoothie with spinach or kale a risk because of thallium, goitrogens, oxalates, or other concerns? 39:20 For someone who is homozygous for the H63D allele of the iron- and hemochromatosis-related HFE gene, if ferritin is low but transferrin saturation is high, should they still donate blood? 48:20 For someone who is taking 45 mg of vitamin B6 as P5P but has xanthurenate, kynurenate, and quinolinate high in the urine as markers of vitamin B6 deficiency, and who is a man with high estrogen, what should they do? 56:18 What to do if taking biotin and yet beta-hydroxyisovalerate is elevated. 57:17 What to do if gamma-tocopherol levels are low-normal while taking 100 IU/d of alpha-tocopherol. 59:30 Does mixing carbohydrate with fat cause people to get fat because of the Randle cycle? (continued at 1:21:00) 1:03:35 Do children need less nutrients than adults because they have lower body weights, or do they need more nutrients than adults because they are growing faster? ( 1:07:12 What to do for a five-year-old who is unusually exhausted, and how to assess their nutritional needs. (Brief followup at 1:35:50) 1:09:30 Concerns about vitamin A intake during pregnancy. 1:12:24 How to use an Oura ring to monitor HRV and optimize recovery and performance. 1:15:40 What are "parent essential oils"? Should we get these instead of cold-water fish oils? Response to Brian Peskin’s theory. 1:21:00 More on whether the combination of carbs and fat makes people fat as a result of the Randle cycle. 1:29:00 Matt stone and the "overdeification" of vitamin A. Or, are there many people who are vitamin A deficient? Hypersensitivity reactions, fatty liver, overzealous use of cod liver oil, and other concerns. 1:35:50 How to deal with the fact that blood tests for nutritional status aren't adapted to children. 1:37:05 How much fatty fish to eat. 1:38:05 Nutritional strategies for glucose 6-phosphate dehydrogenase (G6PDH) deficiency. 1:42:58 If berberine lowers LDL-C and total-to-LDL-C but raises ApoB, what does this mean? 1:45:50 How to interpret the pattern of high citrate, low cis-aconitate, low glutamate, and high glutamine. (Followup at 1:53:05) 1:47:20 What do I think about Loren Cordain, his views on salt and dairy, and his opinion of Chris Kresser? 1:53:55 What to do about acne that gets worse with stress and better with cardio? 1:55:37 For MTHFD1, PEMT and MTHFR, should I be supplementing choline? 1:56:13 How to bring up low levels of arachidonic acid. 1:57:17 Using blood tests to determine whether you should increase your calcium intake. 1:57:45 Alex Leaf answers a question about creatine non-responders and methylation. 1:59:22 Could neurotransmitter levels be artificially low on the Genova ION panel if you fasted for 24 hours before having samples taken? 2:00:07 When to take tryptophan on a ketogenic diet. 2:00:52 When should you take creatine, if you don't have an MTHFR SNP? 2:01:30 My thoughts on PQQ and CoQ10 supplements. 2:02:02 What to do when high selenium levels won't come down, even if you've stopped supplementing. 2:02:24 Is four eggs a day too much? 2:03:05 Are low total omega-6 levels on the ION panel a cause for concern? 2:03:50 What to do about high arsenic. 2:04:24 What to do about fungal infection suggested by elevated D-arabinitol. 2:05:33 Migraines and twitching caused by coffee that responds to electrolytes. 2:09:55 What to do if signs and symptoms of zinc deficiency persist despite taking 75 mg zinc gluconate per day. 2:11:35 What to do if intermittent fasting beginning before 3:00 PM hurts sleep. 2:13:55 What to do about high-normal TSH and no diagnosis of a thyroid disease.    

On this episode, we now know when Jeon Somi officially debuts under Teddy’s Black Label. Additionally, Happyface Entertainment has questions for YG regarding their new survival show during their MIXNINE court case. Also, BTS continues to conquer all that they lay their eyes on. All that, new tunes, including NCT 127, EXID, Mamamoo, and more!What’s New?Kaz[MV] THE BOYZ(더보이즈) _ No AirNCT 127 엔시티 127 'Simon Says' MVMV] Loco(로꼬), GRAY _ Late NightPeteyYubin "Thank U Soooo Much" M/V[EXID(이엑스아이디)] 알러뷰 (I LOVE YOU) M/V (Official Music Video)[MV] 마마무(MAMAMOO) - Wind flowerHeadlinesJeon Somi Debut Timeframe SetJeon Somi To Reportedly Make Solo Debut Next Year - SoompiMore from Happyface vs. YG‘MIXNINE’ court case continues, HFE make a point about YGE & people don’t get it - Asian JunkieBTS Breaking RecordsBTS Breaks The Box Office Bank With 'Burn The Stage: The Movie' - ForbesBTS Becomes 1st Korean Group To Score RIAA Platinum Certification For Single + 1st Korean Artist With A Gold AlbumBig Hit Looking AheadBig Hit’s new boy group to reportedly be 5-member group with average age of 17 and different concept from BTS

Join us for our bonus interview with Gaby Hancock and Ellen Bass from #HFES2018 On this bonus episode, we interview Gaby and Ellen about the Women’s leadership in HFE: past present and future panel. To find out how to get involved with supporting women leaders, visit: www.hfwomensgroup.com Support us on Patreon: www.patreon.com/humanfactorscast Follow us on LinkedIn: www.linkedin.com/company/humanfactorscast Follow us on Twitter: www.twitter.com/HFactorsPodcast Follow us on Facebook: www.facebook.com/HumanFactorsCast Follow us on Soundcloud: @HumanFactorsCast Our official website: www.humanfactorscast.com Follow Nick: www.twitter.com/Nick_Roome Follow Blake: www.twitter.com/DontPanicUX Video/photo editing by Offlineable: www.youtube.com/user/offlineable Join us on Slack: join.slack.com/t/hfcast/shared_i…FmYzRmNmNjYTdmYmQ Take a deeper look into the human element in our ever changing digital world. Human Factors Cast is a podcast that investigates the sciences of psychology, engineering, biomechanics, industrial design, physiology and anthropometry and how it affects our interaction with technology. As an online source for human factors, psychology, and design news, Human Factors Cast is your essential resource for new, exciting stories in the field.

This is Mike Ramos from Your Car Dealer Bond.   I hate to talk politics for several reasons: 1) I'm not sure if anyone cares about my view on something I'm admittedly not that well-versed in. 2) I have always been taught to avoid the political conversation in my 20+ years in Corporate America. 3) I'm terrified to lose half of my customers and listeners we have built so hard to compile. 4) I actually despise politics for the most part.    So why would I actually put any political content out that has nothing to do with California Used Car Dealers? Great question and I'm glad it crossed your brain because it shows that you are paying attention. I only did it because I really do think that I'm not the only one that has never voted or does not vote anymore.   I also think that other people just like me are just trying to scratch out a living and raise their families. And just like me, these same people weren't raised around politics and this landscape is a bit foreign to us. I also strongly believe that others just like me are sick and flipping tired of no one being able to give a straight answer about anything that flies in the face of their side's politics. ---------------------------------------------------------------------------- Please consider connecting with YCDB on Social Media:   Check out Your Car Dealer Bond on Twitter: https://twitter.com/yrcardealerbond   Follow Your Car Dealer Bond on Facebook: https://www.facebook.com/pages/Your-Car-Dealer-Bond/395072210503844   Here's how to find Your Car Dealer Bond on YouTube: https://ycdb.us/YouTube   Connect with Your Car Dealer Bond on Instagram: https://ycdb.us/Instagram   Connect with Mike Ramos on LinkedIn: www.linkedin.com/in/mike-ramos-ycdb   Check out Your Car Dealer Bond on Pinterest: https://www.pinterest.com/yourcardealerbondllc/   ---------------------------------------------------------------------------  President Donald Trump and Hilary Clinton could learn a thing or 2 about how the regular people of America think about politics by listening to episode 11 of the Your Car Dealer Podcast. And although we are probably best known to our audience for being the only podcast dedicated to the success of the used car dealer industry, we are also dedicated to the small business owners that make the United States go around.   Right around the 9:30 mark, I share a hilarious story about the last time I headed off to the voting polls to cast my vote. Email me at mike@yourcardealerbond.com if you have ever heard a more outrageous story about someone going to go pull the lever on either the Democrat or Republican side of the aisle.   At about the 13:59 minute mark I start talking about my assessment of the information that I've routinely seen from Don Lemon at CNN or Sean Hannity. I even mention Ana Navarro, Sonny Hostin, Joy Behar, and Whoopi from The View.   My perspective is that they are all tainted, just depends on by who. It's tough to understand the info when they are ones telling the story because they are too predisposed to a certain angle.   At the 23:55 mark, I discuss my insurance background and the process of an insurance filing getting submitted to the Department of Insurance (DOI). Here's I'm comparing this completely transparent process to the corrupt and murky world of being a political talking head. I apologize for the 6-minute sidebar about the insurance world.   Kudos to the California Department of Insurance for creating this transparency and the California Insurance Guarantee Association (CIGA). I can't stand the California Department of Motor Vehicles (DMV) or many other state-run offices, but the DOI is actually quite impressive.   Somewhere in the neck of the woods of the 29.55-minute mark I start to discuss my thoughts on Serena Williams recent outburst. #HFE. As a previous wrestler, wrestling coach, football player, and football coach, I understand rules and emotion. I also have seen champions at the kid level, high school level, college level, and Olympic level and none of them act the way Serena Williams acted.   I have always respected William's skills and what she had to go through to become a champion and the best that ever lived in her sport, especially given that she grew up in a tough area. That said, this outburst was not champion-like and not something you want your kids trying to emulate. It also doesn't define Serena Williams and a few over-reactions in any career should be expected from the highest level athletes, and not tarnish their reputation in the process.   Special thanks to Google for making it possible to do research in order to put this type of content out into the world. I also thank them for creating such a great search engine that makes it possible for people around the country to find the Your Car Dealer Podcast. Who would have ever thought a kid without a formal education could create a podcast from scratch.   Thanks for tuning into another week of the Your Car Dealer Podcast. Normal content about the used car dealer industry to resume on the next episode. Just mixing it up a bit here. If you like the content, would like to give me some show ideas in exchange for a shot out on the show, email me at mike@yourcardealerbond.com TODAY!   The YCDB Media Team is offering 10 California small business owners wholesale rates on their media needs in 2018. Here are just some of the services that we are going to apply this discounting to:   Professional logo and business card creation. Website design and development. Video Animation Website cloning or duplication. Website redesign to a responsive layout, with quality plug-ins and great loading speed. Complete website audit for security, loading speed, broken links, SEO, and much more! Website conversion from HTML or PHP to Wordpress (so you can make all content changes yourself)! On-Page Search Engine Optimization (SEO). Google My Business or GMB set-up. This is the box of info off to the right side showcasing your business when you Google your business name. Google: “Your Car Dealer Bond” for an example.   Click here to  https://www.cal-surety.com/dealer-business-development/

This week, we discuss the mess that is the fallout from Cube’s initial decision to release HyunA and E’Dawn from their contract and their subsequent indecision on the finality of that move. We also take a bit of time to discuss TS Entertainment standing firm in their unwillingness to settle with Hyosung and YG Entertainment pulling out all the stops to prove a point about their power. All that, plus some great new tunes from Jay Park, both members of 15&, and Girls’ Generation-Oh!GG. Esketit!What’s New?Kaz[MV] GIRIBOY(기리보이) _ Used(옛날거) (Prod. By GIRIBOY(기리보이), MISU) (Feat. Kid Milli)박재범 Jay Park - 'V' (Official MV) [ENG, CHN]PeteyThe Volunteers - S.A.DJimin Park "April Fools (0401)" M/V[MV] SUNMI(선미) _ Siren(사이렌)Girls' Generation-Oh!GG 소녀시대-Oh!GG '몰랐니 (Lil' Touch)' MVHeadlines[Update] HyunA & Pentagon’s E’Dawn booted from Cube, learned about it from news, company continues to change mind - Asian Junkie[Update] Cube indecision on HyunA/E’Dawn due to shareholder anger, situation to be resolved next week - Asian JunkieWe’re Dating, K-Pop Stars Declare. You’re Fired, Their Label Says. - New York TimesTwo K-Pop Stars Came Out As Dating, And Their Label Fired Them - JezebelHyuna, E'Dawn Fans Rally Behind Idols Following Shocking Agency Exit - ComicBook.comK-Pop Is So Strict, It Fired Two Stars for Dating Each Other - Rolling StoneCube has botched the HyunA/E’Dawn situation, but at least it has brought out the memesTS Entertainment And Jun Hyosung Fail To Reach Compromise In Legal Dispute - SoompiYGE hires top Korean law firm to deal with ~$9000 HFE lawsuit over ‘MIXNINE’ debacle - Asian JunkieSomi will reportedly not sign with new agency for now, will let dad manage her instead - Asian Junkie

Podcaster:Caitlyn VlasschaertMedical Discipline/Topic:Hematology, Internal MedicineIntended AudienceYear 1, Year 2, Year 3, Year 4Brief Synopsis/Key Takeaways:1. Think of the 4 major AOLI causes (alcohol, overload, liver, inflammation), keeping in mind that several are likely contributing in one patient.2. Transferrin saturation >45% is highly suggestive of iron overload as a contributing factor, including hemochromatosis, and would warrant referral to hematology. Other key tests to order include: CBC, ESR, CRP, Cr and lytes, LFTs and hepatitis serology (B and C), abdominal U/S, glucose, A1C, lipids, and HFE gene testing if you’re suspicious of hemochromatosis.3. Good rule of thumb: High ferritin is anything >300, but for those in the 300-1000 range, lifestyle modification targeting the non-iron overload causes is appropriate, with hematology referral for ferritin above 1000 as this plus high transferrin saturation is specific for hemochromatosis and phlebotomy may be necessary. Alcohol cessation is also recommended in hemochromatosis.

Welcome to Episode 8 of Software Tech Talks – How the Pro’s Build Reliable Products! Today’s Featured Guest is Ella Cozmi, a Master of Human Factors Engineering whose passion & expertise make her the ‘Go To’ Expert when you’re designing a Medical Device for use in the US or around the Globe. Ella has over 15 years HFE experience, and her specialties include Regulatory, Medical & Clinical development, Clinical Trials & Clinical Evaluations, Usability Studies, Product Usability and User Interface Design. Ella is a Consultant, and her agency, Human Factoring Rx, brings decades of experience to any Biotech project – and as a Registered Nurse with over 20 years of bedside nursing experience – Ella knows first hand what a successful product design looks like. So she can help you avoid product release failures – because she knows what users want!

Hero Future Energies (HFE) is one of India’s leading renewable energy project developers with over a GW of solar and wind assets. Girish Shivakumar interviews Sunil Jain, CEO of HFE and discusses the company’s future plans, building India’s first solar-wind hybrid project and his outlook on India’s RE sector and its targets. If you liked the episode, let your friends and colleagues know about it. A new podcast is released every week.

Today is April 17th, 2018 and it's an all new Human Factors Cast hosted by Nick Roome with Blake Arnsdorff. Tesla Was Kicked Off Fatal Crash Probe by NTSB After Millions of Trials, These Simulated Humans Learned to Do Perfect Backflips and Cartwheels Study finds over 3,300 Android apps improperly tracking kids UK Government Proposes Five Basic Principles to Keep Humans Safe From AI IT CAME FROM REDDIT MS in HCI at DePaul or MS in HFE at SJSU Follow us on LinkedIn: https://www.linkedin.com/company/humanfactorscast Follow us on Twitter: http://www.twitter.com/HFactorsPodcast Follow us on Facebook: https://www.facebook.com/HumanFactorsCast Follow us on Soundcloud: https://www.soundcloud.com/HumanFactorsCast Our official website: https://www.humanfactorscast.com Follow Nick: https://www.twitter.com/Nick_Roome Follow Blake: https://www.twitter.com/DontPanicUX Follow Woodrow: https://www.linkedin.com/in/woodrow-gustafson-4a12197b/ Join us on Slack: https://join.slack.com/t/hfcast/shared_invite/enQtMjQ0MDY3NDAzNzk5LWM2YzJlOGFiNDAwMjBhYTA5ZTNiNGMyZTQ5MzY0NDE0YTVhNTdhNDE3YzM1NjM4ZDg2Y2FmYzRmNmNjYTdmYmQ Take a deeper look into the human element in our ever changing digital world. Human Factors Cast is a podcast that investigates the sciences of psychology, engineering, biomechanics, industrial design, physiology and anthropometry and how it affects our interaction with technology. As an online source for human factors, psychology, and design news, Human Factors Cast is your essential resource for new, exciting stories in the field.

In episode 32, I tell the story of my personal story with iron overload, and weigh in on the proper use of blood tests and strategies to manage anemia, hemochromatosis, and everything in between. It's important to realize that these are the extremes, and there is a large middle space where we need to not only manage how much iron we accumulate, but how we direct it away from its disease-promoting roles and into its health-promoting roles. This is a great primer on iron as well as a source of insights you may not have encountered elsewhere, such as the importance of oxidative stress as an independent regulator of ferritin, and the potential dangers of supplements designed to protect against oxidative stress like milk thistle, Protandim, sulforaphane, and green tea extract, for people at risk of anemia. You can find the show notes to this episode at chrismasterjohnphd.com/32. This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice. This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order. In this episode, you will find all of the following and more: 0:33 Cliff Notes; 10:30 Introduction; 13:12 My personal story with iron overload; 30:12 The physiological roles of iron: hemoglobin, myoglobin, nitric oxide synthase, iron-sulfur clusters in the cytochromes of the electron transport chain, guanylyl cyclase, thyroid peroxidase (TPO), myeloperoxidase (MPO), oxygen transport, energy and ATP production, cellular regulation, thyroid hormone production, immunity; 38:20 Iron as a source of oxidative stress: free iron, hydrogen peroxide, and the hydroxyl radical, oxidative stress as an independent regulator of ferritin; 41:10 Regulation of iron status; Ferritin, long-term storage, protector against pathogens, protector against oxidative stress; Transferrin, short-term iron storage; Hepcidin, master coordinator of iron metabolism; HFE, communicator between transferrin and hepcidin; 49:10 Regulation of dietary absorption of plant and animal iron; 51:00 Measuring and assessing iron status: complete blood count (MCH, MCV, RDW, CHr), full iron panel, sensitivity and specificity of transferrin saturation versus ferritin, differential interpretation of ferritin as a marker of iron overload, inflammation, or oxidative stress; 1:11:43 What to do for anemia: differentiate potential causes, iron in foods (heme, nonheme, vitamin C, polyphenols, phytate, calcium), iron in supplements (iron-saturated lactoferrin, heme iron, liposomal iron), avoid Nrf2-stimulating supplements (like Protandim, sulforaphane, milk thistle, green tea extract), importance of followup measurements of ferritin 01:21:03 What to do for iron overload: blood donation, dietary management, phlebotomy, chelation, importance of followup  

High Frequency Economics' Carl Weinberg weighs in on the IMF spring meeting and how HFE is bearish on the global economy on Bloomberg Surveillance with Tom Keene and Michael McKee. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

High Frequency Economics' Carl Weinberg weighs in on the IMF spring meeting and how HFE is bearish on the global economy on Bloomberg Surveillance with Tom Keene and Michael McKee.

Iron levels and biochemistry have impacted my personal performance in a dramatic way. Recently I've been racing cyclocross, something for which I lack talent. For those of you who don't know cyclocross, it's a lot like short track mountain bike racing but most of the bikes look a road bike with drop handlebars. The start is really important, and the course has hundreds of corners and so the sport doesn't suit slow-twitch athletes like me. This year I’ve been enjoying some dramatic gains in my performance. These gains are nothing to do with training, in fact, I've been training less than ever before. The key to performance is health, and that's why I've got Dr. Tommy Wood on again today to talk about some of the biochemical tweaks I've been making and also the serious issue of iron overload (haemochromatosis). First let’s talk about anaemia. Some people think of anaemia as synonymous with iron deficiency, but iron deficiency is just one of many things that can cause anaemia. Diagnosing anaemic tendencies requires the consideration of the production, destruction and loss of red blood cells. Other nutrients such as zinc, B6, B12 and folate are as important as iron for the production of red blood cells. Sometimes we see results that show both iron overload and anaemia. Why is iron overload a problem? Most micronutrients cause little harm when consumed in excess. Vitamin C is a good example--consume too much and you'll simply pee it out. Excess iron is different in that there's no easy way to excrete it. The main way we lose iron is through bleeding, and for men and postmenopausal women this doesn't happen very often. Excess iron becomes bound to proteins and acts as a pro-oxidant, literally causing your tissues to rust. If left untreated, the excess iron can cause diabetes, cirrhosis of the liver and a host of other chronic diseases. The day after we recorded this interview four of my six follow-up appointments were with masters athletes with iron overload. Please don't guess, do the test! How should your diet change if you are diagnosed with iron overload? Research shows diet can have an impact of the absorption of iron. Things that block iron absorption: Calcium rich foods like dairy, leafy vegetables and sardines (whole with bone). Phytates from leafy vegetables and nuts. Tannins in red wine and coffee. Anthocyanins in any colour berry (the darker the colour of the berry the better). Things that increase iron absorption: Vitamin C. Added fructose, table sugar. Blood testing for iron levels is not that difficult to do. In fact, my team can do it for you. Iron overload can be ruled out as part of our O2 Boost programme. Place your order and I'll send you a PDF requisition form that you can print and take directly to LabCorp--no need for a visit to your doctor's office. The results will be back in just a couple of days and then I'll send you a written report and a link to my schedule that you can use to make an appointment for the included 30-minute call. Here’s the outline of this interview: [0:02] Introduction to today’s show with Dr. Tommy Wood. [0:18] An upcoming live event where Dr. Wood will be speaking. [2:06] Why would you even care about iron overload? [4:55] You can run your blood chemistry through Nourish Balance Thrive. [5:36] What is iron and why is it needed in human biology? [7:09] Ways you can tell if you have an iron deficiency. [8:54] Is there any evidence to show that athletes could be in danger of Anaemia? [11:14] Why is iron overload a concern and mutations in the HFE gene. [15:37] What blood markers should be watched to determine iron levels? [17:06] What can happen when there is too much iron (one example)? [21:29] How a good handle on your iron levels can be a major win for your life and competition. [22:06] What should be done if iron overload is discovered? [23:30] Bloodletting as a solution? Really? [30:25] How should a person who’s a victim of iron overload change their diet? [37:45] The importance of testing then trying various solutions, and testing again. [38:23] What is Lactoferrin and how does it relate to iron issues? [42:23] How can Lactoferrin be used as an anti-microbial? [43:03] How to get a blood test from the Nourish Balance Thrive team. RESOURCES MENTIONED IN THIS EPISODE Haemochromatosis O2 Boost Primal Docs Re-find Health Get your blood chemistry done by the Nourish Balance Thrive team Webinar with Tawnee Prazak Richard Nikoley’s article about iron 23andMe (salivary genetic test) MTHFR Support Medscape error: The second mutation involves a G→C substitution at nucleotide 197, leading to a histidine to aspartic acid substitution at amino acid position 63 (H63D). Iron Disorders Institute The Iron Chart Christopher Mentioned (PDF download) Blog Post: In Defense of Low Fat Diets Inositol Hexaphosphate Lactoferrin British Journal of Nutrition paper on Lactoferrin The Spritzlet App PEOPLE MENTIONED IN THIS EPISODE Chris Armstrong Richard Nikoley Dr. Jaime Busch Jimmy Moore Denise Minger Vinnie Tortorich

Joel Manby is the new CEO of SeaWorld Parks & Entertainment seaworldentertainment.com and former President and Chief Executive Officer of Herschend Family Entertainment,[1] the largest family-owned theme park corporation in the United States. HFE creates, develops and operates entertainment, tourism and hospitality properties spanning 26 locations in ten states, including Stone Mountain Park, Dollywood and Silver Dollar City.[2] He and his company were featured in the sixth episode of the first season of CBS's Undercover Boss. Manby also wrote Love Works about HFE's unique business culture, with all proceeds going toward the Share It Forward Foundation, the company's charitable organization which aids employees in need. SeaWorld Parks and Entertainment has named Joel Manby as its new president and CEO, effective April 7. Bill Salus is the author of "Nuclear Showdown in Iran, Revealing the Ancient Prophecy of Elam," "Psalm 83: The Missing Prophecy Revealed, How Israel Becomes the Next Mideast Superpower," "Revelation Road, Hope Beyond the Horizon," and "Isralestine, The Ancient Blueprints of the Future Middle East." Bill is an expert at explaining the prophetic relevance of current Middle East and world events. His books have been featured on TBN, Daystar TV, CBN, and many other mainstream Christian TV shows and networks. Bill's freelance articles have been featured on World Net Daily, The Christian Post, popular magazines, and extensively over the World Wide Web. Readers appreciate his unique insights, and sensible, rather than sensational approach to understanding the Bible. He allows prophecy to speak for itself, rather than modernizing it into newspaper exegesis. In addition to being an author and a lecturer, Bill is also the radio host of the popular Prophecy Update Radio Program featured at KFHM 88.7 FM. Bill interviews the highly respected prophecy experts and discusses with them today's most important end time's topics. In addition to hosting his radio program Bill is frequently interviewed on other radio programs, and has appeared on television shows like Christ in Prophecy, hosted by Dr. David Reagan founder of Lamb and Lion Ministries, and Jewish Voice, hosted by Jonathan Bernis. Shortly after becoming a Christian in 1992, writing became a daily discipline for Bill. He began with devotional pieces, but soon realized that he was prophetically inclined. After the events of September 11, 2001, along with the encouragement of Dr. Arnold Fruchtenbaum the founder of Ariel Ministries, Bill embarked upon a tireless path of discerning prophecies that apply today. It has become Bill's personal challenge to demonstrate the love of God through prophecy to each reader. As he composes one page upon another, it becomes clear to the spectator that prophecy is a spectacular gift from a God who cares for the entirety of humanity. The discovery of prophecy as a gift rather than a threat is what most characterizes Bill's work. People all over the world are learning through his steadfast efforts, that prophecy is not just for the scholarly, but also for every common man, woman, and child. Whether writing, teaching, doing interviews, or speaking in front of large and diverse audiences, Bill guarantees to impart understandable information Midwatch interviews Christian authors, artists, movie producers, indie film makers, ministers and just about anyone with a story of faith. The show is built around discussing faith and building encouragement to our listeners. Broadcasting primarily online through our servers to the world and across the USA on RevMedia Network. Midwatch has reached over 3.5 million listeners over the past 3 years. Join us for a show full of faith, humor, special guests, truth, entertainment and encouragement.