Podcasts about Survivin

Andre Cymone is a renowned musician, producer, and songwriter who first made his mark as the bassist for Prince's early band. Born in Minneapolis, Cymone played a pivotal role in shaping the Minneapolis sound, a unique fusion of funk, rock, and new wave. His contributions to Prince's groundbreaking early albums helped define an era and set the stage for his own successful solo career. As a solo artist, Cymone released several critically acclaimed albums in the 1980s, including "Livin' in the New Wave" and "Survivin' in the 80s," showcasing his versatility and talent as a multi-instrumentalist.In addition to his solo work, Andre Cymone has built a reputation as a sought-after producer, collaborating with a diverse array of artists across genres. He has worked with notable figures such as Jody Watley, with whom he co-wrote the hit song "Looking for a New Love," and Adam Ant. Cymone's ability to seamlessly blend different musical styles has kept him relevant in the ever-evolving music industry. Today, he continues to influence and inspire new generations of musicians with his innovative approach and enduring passion for music. He will release his new album "Resurrection of Funk" in late 2024. _____________________Rock and Roll Hall of Famer Prince featured the "Upper Room with Joe Kelley and Gi Dussault" on his official website www.npgmusicclub.com. This is the first radio show to have ever received that honor. "Musicians Reveal with Joe Kelley" has been on the radio airwaves since 1982. Joe Kelley and Gi Dussault co-host the show and are well-respected in the music business as creative air personalities and supporters of independent musicians . Our web site is located at www.musiciansreveal.com . The show features creative music in funk, R&B, jazz, blues, rock, hip-hop, latin, and gospel. In addition, Joe Kelley has interviewed renowned musicians such as Victor Wooten, Sheila E. , Foley, Robin Duhe, Jef Lee Johnson, Jellybean Johnson, Monte Moir, Rhonda Smith, Bernie Worrell, Cyndi Lauper, Michael Bland, Larry Graham, Chris Frantz and Tina Weymouth, Steve Smith, St. Paul Peterson, JD Blair, Tori Ruffin, Kat Dyson, Eric Person, actor Jeff Daniels, Junior Giscombe, John Scofield, EC Scott, John Blackwell, Mystic Bowie, and many others.

Send us a Text Message.Ever wondered how the suburban scandals of "Knots Landing" could school us in the fine art of fiscal finesse and family dynamics? Buckle up, because that's precisely what we're about to explore. With my sassy commentary turned up to eleven, we're dissecting the "Courageous Convictions" episode, where Richard's financial floundering and Diana's love life complications serve us a hearty slice of drama pie. As we scrutinize the generational divide of aspirations and the silent battles of the heart, prepare to chuckle and gasp in equal measure.Hold onto your hats – and perhaps your wallets – as we navigate through the choppy waters of monetary deception and relational tension that could give any telenovela a run for its money. From Terry's bargain car-fix to Diana's rose-colored glasses, we break down the episode's juiciest moments with humor and a dash of empathy. We also ruminate on the life lessons served up by Laura's and Richard's marital tiff over the family checkbook, all while keeping you entertained with our play-by-play analysis of their every misstep.As we wrap up our suburban saga, I'll share some generational wisdom, inspired by Strauss and Howe's "Generations," that could just save your bank account from a fate worse than a soap opera cliffhanger. We'll contrast Laura's "Great Generation" loyalty with Diana's boomer-esque bravado, and Sid's Silent Generation stability, all while sprinkling in some tips for living frugally without scrimping on fun. So pour yourself a glass of your favorite beverage, and let's toast to financial literacy with a twist of soap-style storytelling!

This episode, we're talking about one of my favorite TV shows of all time: Sanford & Son! We'll also get into Good Times and a little into The Jeffersons. All 3 of these shows are 1970s Black sitcoms under Tandem Productions. These shows were a window into the reality of Black life like nothing before them. Yet, what often gets overlooked in discussing these shows is the work that Black actors and writers did behind the scenes to demand respect for themselves and authentic depictions of Black people on screen. Enter my guest Dr. Adrian Sebro, author of Scratchin' and Survivin' Hustle Economics and the Black Sitcoms of Tandem Productions, to tell us some of these behind the scenes stories.Music CreditPeaceLoveSoul by Jeris (c) copyright 2012 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/VJ_Memes/35859 Ft: KungFu (KungFuFrijters)

This week I invited my longtime friend and brother from another mother, MarQuis, to join me on the couch. MarQuis has been riding with me since college and we've seen each other through so many ups and downs. We talked about everything from coming out, heartbreak, his heart condition and so much more. Make sure you check out his non-profit www.thebeatitfoundation.

This week yours truly Jimmy J and Horror Daddy sat down with the stars of Hell House LLC Origins: The Carmichael Manor, Bridgett Perrotta and Destiny Brown along with writer and director of the film Stephen Cognetti! We're discussing some behind the scenes action and experiences on set, favorite moments, paranormal activity at manor, the future of Hell House, and much more. Make sure you stay to the end as we have a special guest that joins the party! TIMELINE 1:24-INTRO 1:49- Intro into Horror 3:01- Getting started/upbringing 7:46- Bridgett's experience on set / getting into character 10:36- Destiny's experience on set / getting into character 15:20- House listing scene 18:14- Filming location / Survivin' Drivin' 21:53- Real Paranormal activity at the Manor? 25:08- Do you believe in Ghosts? 28:00- New Hell house LLC movie on the horizon??? Future event at the Waldorf Estate of Fear (aka the Abaddon hotel)??? 32:33- Bridgett's favorite moment of filming 34:33- Destiny's favorite moment of filming 36:34- Building camaraderie 38:20- 2 minute drill Bridgett 42:26- 2 minute drill Destiny 45:23- Other horror franchises Destiny & Bridgett would love to be a part of 48:04- More behind the scenes 55:23- 10 years from now // Hell House LLC Origins Premiere 1:05:00- Upcoming projects and KILLER Conclusion! Follow Destiny on Instagram @DestinyleilaniBrown Follow Bridgett on Instgram @Bridgetroseperrotta Follow Stephen Cognetti on Facebook: https://www.facebook.com/scognetti Check out Hell house LLC Origins: The Carmichael Manor on  @shudder  Follow and LIKE Hell House LLC on Facebook at: https://www.facebook.com/HellHouseLLC Check out this and other films produced by Terror Films at: https://www.terrorfilms.net/ Bridgett's Website: https://www.bridgetroseperrotta.com/ Destiny's Website: https://www.destinybrown.org/ #hellhouse #horror365 #hellhousellc #terrorfilms #haunts #shudder IG ⁠⁠@HorrorHeads365⁠⁠ // Jimmy J- @JimmyJ.ENT // Steve Roman=@teezus_official // Sean Telepo- @metalsean // Josh Curzi- @Horrordaddy85// Ian " The Wolfman" @universalstudiosmonsters // Jonny Sparxx- @aliensinmyattic Any questions or comments EMAIL US! Horrorheads365@gmail.com Thank you for your support and for celebrating Horror...365!!! --- Support this podcast: https://podcasters.spotify.com/pod/show/horrorheads365/support

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit podcastchoices.com/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/african-american-studies

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit podcastchoices.com/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit podcastchoices.com/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/film

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit podcastchoices.com/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/performing-arts

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit podcastchoices.com/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/american-studies

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/communications

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit megaphone.fm/adchoices

The 1970s was a golden age for representations of African American life on TV sitcoms: Sanford & Son, Good Times, The Jeffersons. Surprisingly, nearly all the decade's notable Black sitcoms were made by a single company, Tandem Productions. Founded by two white men, the successful team behind All in the Family, writer Norman Lear and director Bud Yorkin, Tandem gave unprecedented opportunities to Black actors, writers, and producers to break into the television industry. However, these Black auteurs also struggled to get the economic privileges and creative autonomy regularly granted to their white counterparts. Scratchin' and Survivin': Hustle Economics and the Black Sitcoms of Tandem Productions (Rutgers UP, 2023) discovers surprising parallels between the behind-the-scenes drama at Tandem and the plotlines that aired on their sitcoms, as both real and fictional African Americans devised various strategies for getting their fair share out of systems prone to exploiting their labor. The media scholar Adrien Sebro describes these tactics as a form of “hustle economics,” and he pays special attention to the ways that Black women—including actresses like LaWanda Page, Isabel Sanford, and Esther Rolle—had to hustle for recognition. Exploring Tandem's complex legacy, including its hit racially mixed sitcom Diff'rent Strokes, he showcases the Black talent whose creative agency and labor resilience helped to transform the television industry. Adrien Sebro is an assistant professor of media studies at the University of Texas at Austin. He specializes in critical media studies at the intersections of comedy, gender, and Black popular culture. Peter C. Kunze is a visiting assistant professor of communication at Tulane University. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/popular-culture

This week Corporal, Sarcastro and Fatty pull out their stashes (of bourbons) and talk about what types they've been enjoying and migrate into Fatty's continued attempts to improve his new toy the utility golf cart as Sarcastro tries to convince him to give it a Carolina Squat lift.  Continuing with the theme of talking about vehicles, Fatty explains an ongoing issue with the rental car compnay he used when he drove to visit Sarcastro over the summer and how he feels about being a gold member with them.   They also discuss Fatty's return to work after the summer break and the less than desirable conditions of the building he works in but he's still alive.   Intro and Outro music written and performed by Andrés Rodríguez (Androzguitar).

It's Women's Empowerment Month! Welcome back to episode 5! We finna read about people who thrive! You can only beat someone down so much before they level up over you and they will always surpass you whether you want them to or not! From learning life lessons to the sweet, sweet feeling of comeuppance, we're going to tacobout it. How can we break cycles? By talking to those who came before us and having real conversations. We don't have to make mistakes to learn from them. It sucks when you're in the thick of it but it always makes for a great story time. Something I always say is if I can save someone else from making my mistakes, I'm gonna shout it to the stars! Grab your Vibes N Delites and LET'S KEEP GOING!! We gonna learn something new together! 11:11 "I don't know if he ever got his coffee" 37:04 Slappa's Choice "What's your "living well is the best revenge" story?" 1:02:28 "I was able to simultaneously gain a 30k per year pension for my Mother while wiping my piece of shit father's retirement."

If you don't heal from what hurt you, you will bleed out on people who didn't even cut you.

Join us on this episode as we tackle "America's Injustices". Episode Survival Tip: We cannot accept the world as it is. Each day we should wake up foaming at the mouth because of the injustice of things. If the misery of those that are different from us are caused by the laws of our institutions, great is our sin.

Survival Tip: “You don't get betterness from bitterness”. On this episode discuss surviving jealousy from others and you being jealous as well. We can make it! As the song of Jill Scott "I Keep" says: Some of them wanna break you down; Steal your crown; Use and abuse you; Some of them smile in your face; 'Cause they've heard it some place; You got more than they're used to; Some of them want to steal your love; Oh, because they're jealous of how you're living; And giving Moving forward, pressing onward, striving further Keep on laughing, keep on living, keep on loving, yeah Keep on dreaming, keep on achieving, keep on believing.

Surviving' Failure. We are afraid to fail because we sometimes get consumed on what the consensus would say. Don't let people judge you who if were in the same situation it would have broke them into the pieces. Now when you bounce back, don't go chasing after those people who laughed at your demise. This should be the last day that you doubt yourself, fear change or quit.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.09.515885v1?rss=1 Authors: Biber, J. C., Sullivan, A., Brazzo, J. A., Krajnik, A., Heo, Y., Poppenberg, K. E., Tutino, V. M., Heo, S.-J., Kolega, J., Lee, K., Bae, Y. Abstract: Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease and a key risk factor for cardiovascular disease events. The increased stiffness of arteries triggers the hypermigration and hyperproliferation of vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia and accelerated neointima formation, but the mechanism of this trigger is not known. Our analyses of whole-transcriptome microarray data sets from mouse VSMCs cultured on stiff hydrogels simulating arterial pathology and from injured mouse femoral arteries revealed 80 genes that were differentially regulated (74 upregulated and 6 downregulated) relative to expression in control VSMCs cultured on soft hydrogels and in uninjured femoral arteries. A functional enrichment analysis revealed that these stiffness-sensitive genes are linked to cell cycle progression and proliferation. Furthermore, we found that survivin, a member of the inhibitor of apoptosis protein family, mediates stiffness-sensitive cell cycling and proliferation in vivo and in vitro as determined by gene network and pathway analyses, RT-qPCR, and immunoblotting. The stiffness signal is mechanotransduced via FAK and Rac signaling to regulate survivin expression, establishing a regulatory pathway for how the stiffness of the cellular microenvironment affects VSMC behaviors. Our findings indicate that survivin is necessary for VSMC cycling and proliferation and regulates stiffness-responsive phenotypes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.24.513582v1?rss=1 Authors: Krajnik, A., Nimmer, E., Sullivan, A., Joseph, B. A., Heo, Y., Krug, A., Kolega, J., Heo, S.-J., Lee, K., Weil, B. R., Kim, D.-H., Bae, Y. Abstract: Vascular dysfunction is a common cause of cardiovascular diseases characterized by the narrowing and stiffening of arteries, such as atherosclerosis, restenosis, and hypertension. Arterial narrowing results from the aberrant proliferation of vascular smooth muscle cells (VSMCs) and their increased synthesis and deposition of extracellular matrix (ECM) proteins. These, in turn, are modulated by arterial stiffness, but the mechanism for this is not fully understood. We found that survivin (an inhibitor of apoptosis) is an important regulator of stiffness-mediated ECM synthesis and intracellular stiffness in VSMCs. Whole-transcriptome analysis and cell culture experiments showed that survivin expression is upregulated in injured femoral arteries in mice and in human VSMCs cultured on stiff fibronectin-coated hydrogels. Suppressed expression of survivin in human VSMCs and mouse embryonic fibroblasts decreased the stiffness-mediated expression of ECM components implicated in arterial stiffness, namely, collagen-I, fibronectin, and lysyl oxidase. By contrast, expression of these proteins was upregulated by the overexpression of survivin in human VSMCs cultured on soft hydrogels. Atomic force microscopy analysis showed that suppressed or enhanced expression of survivin decreases or increases intracellular stiffness, respectively. These findings suggest a novel mechanism by which survivin modulates arterial stiffness. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Taking care of self as the holidays begin to creep in can be tricky. You want to hang out with friends, family, your cuffing MVP but that can lead to little to no time for you to decompress. Nisha has her solutions and Kiya has hers. Which route do you prefer to take?Don't forget to follow us on Instagram, Facebook and TikTok at @wineortequilapodcast; Twitter @wineortequila and/or email us at wineortequila@gmail.com.Rate, Review and Subscribe!

This week on Historically Inaccurate, after all the hype, build up, and preparation, Historical Survivor finally begins. Which figures will make it to the end, and which ones will fail miserably? Join Jake and Alex as they crunch the numbers and find out who will win.About the Show: Historically Inaccurate is back for Season 4! This is the weekly History/Comedy podcast where host Jake Truemper, right-hand man Alex Schulte, and producer Jackson Parker (along with a cast of recurring characters) play games, role-play scenes, and hold a cell phone flash light to the corners of history while trying to keep everything from falling apart.New episodes every Monday on Apple Podcasts, Spotify, and wherever else you find your podcasts.Historically Inaccurate is produced and distributed by the L.A.S. Media Network in Cedar Rapids, IA. For more, visit LASMediaNetwork.com.Subscribe to L.A.S.+ for just $10/month and get bonus episodes of this show, ad-free versions of every L.A.S. Network Show, pre-sale access to live events, early access to special podcasts and projects, and more benefits, all while support local Iowa creators and businesses. For more information and to get started, head to LASMediaNetwork.com/plus.

Here we are - one week until the start of the NFL regular season! The boys are getting giddy and this week they chat survivor week 1 picks, lots of bold predictions, some fantasy sleepers, and as always they give their picks. Hit us up on Facebook, Instagram, and Twitter @HusTalking and @WeirdMic! If you want to be featured on the show, slide into our DMs, send us your picks, and we'll read the best ones on air. Stay tuned for the season-long point spread contest details.

I think it's interesting that a protein in our bodies, that we develop when we are young and shuts off as we get older, that's labeled "Survivin" can actually be used to fight Glioblastoma and potentially other rare cancers. A protein called Survivin has the word "survive" in it. Isn't that thought provoking! It's like the Universe is giving us what we need to fight this deadly cancer. Our guest today, Dr. Mike Ciesielski, is a co-inventor of the survivin vaccine (SurVaxM) technology on which the company MimiVax was founded. He sits down with us to talk about how this little protein is being manipulated to "vaccinate" our bodies, including the brain, again further GBM growth and cell proliferation. It's a fascinating episode you won't want to miss!   Season Sponsor: Gamma Tile   Episode Sponsors: Mimivax & OncoSynergy Inc.

Our Hard'N'Heavy series of podcasts focuses on new traditional metal and hard rock releases ... along with the odd hard rock'n'roll and melodic punk outing. Basically anything that doesn't fit on our Extreme Metal, Hardcore Punk or Doom series! This edition we focus on July and August 2022 releases. Horns up! (00:00) "Spirit of Death" SAVAGE MASTER - Those Who Hunt At Night Savage Master (bandcamp.com) (03:34) "Sadan Son Sadan Far" STROM - Strom STRÖM (bandcamp.com) (7:08) "Storming Venarium" VANQUISHER - An Age Undreamed Of An Age Undreamed of | Vanquisher (bandcamp.com) (11:58) "Valhalla Has Locked Its Doors" RESISTANCE - Skulls of My Enemy RESISTANCE (bandcamp.com) (16:11) "Survivin' Rock'N'Roll" ZEREMONY - Survivin' Rock'N'Roll Zeremony (bandcamp.com) (21:28) "Siren of the Air" STEEL INFERNO - Evil Reign Steel Inferno (bandcamp.com) (24:44) "Charity Defiler" BARBARIAN - Viperface Viperface | BARBARIAN (bandcamp.com) (28:27) "Smart Kills" ARMSTRONG GUN - Armstrong Gun Armstrong Gun | Armstrong Gun (bandcamp.com)

Andrew Hall is the CEO of IMV Inc, which has developed a platform based on a lipid-in-oil technology that encapsulates the therapeutic.  When injected subcutaneously, the drug remains in a specific location to reinvigorate the immune system to overcome the tumor surveillance that allows cancer to grow. Andrew explains, "There is a checkered history in oncology drug development that is known as vaccines in oncology. For the longest period of time, they were so exciting and, unfortunately, so disappointing in the way they performed clinically. We believe with the technology that we've created at IMV, that we can make vaccines in oncology cool again. We are creating an ability to educate the immune system in a prolonged way, in a way that may present a historical retraction of why things failed before, or maybe it wasn't the targets that made them fail. Maybe it was the way in which the targets were delivered in a meaningful way." "The initial clinical trials are around a lead product, maveropepimut-S. So the target there is Survivin. Survivin is a target that's been well understood in cancer biology for a long time because it is very typical for a lot of cancers. One of the challenges we have as a company is that we have a number of targets that we could go after in cancer, but we just don't have all of the money in the world. So the reason we've chosen the targets we have, and these are ovarian cancer, these are DBCL, so Diffuse Large B-cell lymphoma basically, and then bladder cancer and other solid cancer is, we know that these cancers are highly overexpressing the target of Survivin. And we know that Survivin, and it's kind of akin to its name, is required for the cancer cell to survive." @IMV_inc #Immunotherapies #Immunotherapeutics #Cancer #Oncology #LipidinOilTechnology #Survivin #Halifax #NovaScotia IMV-inc.com Listen to the podcast here

Andrew Hall is the CEO of IMV Inc, which has developed a platform based on a lipid-in-oil technology that encapsulates the therapeutic.  When injected subcutaneously, the drug remains in a specific location to reinvigorate the immune system to overcome the tumor surveillance that allows cancer to grow. Andrew explains, "There is a checkered history in oncology drug development that is known as vaccines in oncology. For the longest period of time, they were so exciting and, unfortunately, so disappointing in the way they performed clinically. We believe with the technology that we've created at IMV, that we can make vaccines in oncology cool again. We are creating an ability to educate the immune system in a prolonged way, in a way that may present a historical retraction of why things failed before, or maybe it wasn't the targets that made them fail. Maybe it was the way in which the targets were delivered in a meaningful way." "The initial clinical trials are around a lead product, maveropepimut-S. So the target there is Survivin. Survivin is a target that's been well understood in cancer biology for a long time because it is very typical for a lot of cancers. One of the challenges we have as a company is that we have a number of targets that we could go after in cancer, but we just don't have all of the money in the world. So the reason we've chosen the targets we have, and these are ovarian cancer, these are DBCL, so Diffuse Large B-cell lymphoma basically, and then bladder cancer and other solid cancer is, we know that these cancers are highly overexpressing the target of Survivin. And we know that Survivin, and it's kind of akin to its name, is required for the cancer cell to survive." @IMV_inc #Immunotherapies #Immunotherapeutics #Cancer #Oncology #LipidinOilTechnology #Survivin #Halifax #NovaScotia IMV-inc.com Download the transcript here

Elon Musk's battle for Twitter continues as he runs into many different hurdles trying to acquire this insane, Marxist, Leftist company. The Left unfortunately tries to take advantage of another tragedy as we see another shooting in Buffalo, New York. And we are now in a recession, according to me, but will we get to a depression? Find out now, here, on The Conservative Connection.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

This month's Survivor guest is Robyn Bloom. A REAL ONE, to say the least. Robyn is a life coach practitioner, author, mentor, and mother to a group of awesome young women. She like to acknowledge that she is also a former victim of her own bullshit (her words, not mine LOL). She likes to use the word former because she now takes time to hold herself accountable for any chaos and toxic energy she brings. In 2016, while in the hospital dying, her journey began. In that hospital bed, she started forgiving herself for some of her decisions and found a little peace. For her, it was that peace that saved her life. During her search for self, she became a life coach. And in 2020, she was blessed to rehab a house that she affectionately named The Healing House. This is where she works with women and girls doing healing, bonding, and meditation. Robyn believes that we all have the power to heal but it takes hard work, dedication, and a strong support system. She's definitely the survivin' girlfriend you didn't know you needed. --- Support this podcast: https://anchor.fm/mysurvivorvoice/support

hi guys! this week I sat down and chatted. life has been a rollercoaster of emotions and stresses lately. i'm sure it is something we are all feeling as the year transitions to fall. i hope you enjoy this episode xxx Podcast Instagram: @vibinandthrivinpodcast Personal Instagram: @_ciaramariewagner --- Support this podcast: https://anchor.fm/ciara-wagner5/support

Kick up your feet and get ready for jests, our party is starting their Song of Rest! Take a seat with us in our post show as we talk about the last episode, goof off - and let Timothy Biscuit's lute sooth our battle wounds. Available now wherever you get your podcasts! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Heading further into the island of Praxil, the three chosen heroes of Miriam hurry to warn the inhabitants of the looming threat on their tail. It doesn't look to be an easy road, however. Perhaps a little traveling music could help ease the journey. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Heute geht es um das „Überleben“. BΔSTILLE haben mit „Survivin`“ ein Stück darüber geschrieben. – Denn das Leben kann in den derzeitigen Zeiten sehr frustrierend sein, in denen alles, was früher mein Leben definiert hat, auf einmal nicht mehr zu existieren scheint. Das Letzte, was ich hören möchte, sind Geschichten über Dinge, die nur in Träumen und Fantasien existieren. BΔSTILLE gelingt es in "Survivin" den Weg von der Niedergeschlagenheit zur Hoffnung textlich und musikalisch zu zeichnen. “And I'm not gonna lie/ Say I'll be alright/ ‘Cause it feels like I've been living upside down“- Aber dann heißt es“crawling out these sheets to see another day“- Diesen Weg wollen wir in diesem Podcast nachspüren. BΔSTILLE machen mir Mut, mich nicht auf Follower und Klüngel zu verlassen, sondern mir zu überlegen – wo kann ich mich fallen lassen - wo kann ich so sein wie ich bin, wo werde ich aufgefangen. BΔSTILLE singen von unserer Sehnsucht nach Verbindlichkeit in einer Zeit der Unverbindlichkeit. Ich brauche Orte wo ich alles ablegen kann, wo ich nackt sein kann, ohne Filter und Feigenblätter – ohne Schutz, weil ich keine Angst haben muss, mich zu zeigen. – Das ist das was ich brauche, um Atem zu holen und eben als Survival-Bag, als Überlebensausrüstung, dies ist mit „I'm not gonna lie“ gemeint. Heutzutage beantworten viele die Frage: Wo kann ich ich selbst sein, wo muss ich nicht so tun als ob ich mehr oder etwas anderes wäre – mit: „wenn ich alleine bin“ – wie schade eigentlich. Daher finden Menschen Kontakte anstrengend, weil sie sich einreden, immer Gas geben zu müssen, um toller zu sein als sie eigentlich sind – aber in sich tragen sie das tiefe Bedürfnis sie selbst zu sein – Heute haben wir das Privileg Beziehungen frei wählen zu können – das ist schön, es erzeugt aber auch den Druck beliebt zu sein, gewählt zu werden, gut genug zu sein - es „wert“ zu sein. BΔSTILLE schenken Zuversicht im Miteinander den Fokus auf das Überleben zu legen, also sich gegenseitig zu stärken, sich zu unterstützen und nicht immer auf den Wettbewerb zu blicken – dazu müssen ich erstmal ehrlich sein und genau schauen wie das bei mir ist, mir nicht mehr die Welt schön lügen – „I´m not gonna lie.“ Daran könnt ihr ja denken wenn ihr den Song jetzt jeden Tag in der Woche hört. Die Songtexte werden von Theresa gelesen @last_minute_task_ninja Foto: © Sarah Louise Bennett/Universal Homepage: https://7tage1song.de Playlist Podcast und Song: https://open.spotify.com/playlist/20KHRuuW0YqS7ZyHUdlKO4?si=b6ea0b237af041ec Instagram: https://www.instagram.com/7tage1song/ Facebook: https://www.facebook.com/pg/7tage1song/ Kontakt: post@7tage1song.de Link zum Song: https://songwhip.com/bastille/survivin-one-eyed-jacks-session Spotify Playlist: https://open.spotify.com/playlist/0M5tOXTC0lM8RVycUBQnjy?si=idKC-CFaRp2ZD992gvWvsQ

Projekt "Survivin' Staatsexamen" - Mein persönlicher 10-Punkte-Schlachtplan Es ist soweit: Mein Staatsexamen steht vor der Tür. 14 Prüfungen in 5 Monaten - diese Prognose hat definitiv Potenzial für so manche Gefühls-Achterbahnfahrt, auf die ich euch in dieser Podcastfolge mitnehme. Außerdem hab' ich mir ein paar Gedanken gemacht, mit welchen persönlichen Leitlinien ich versuche, möglichst gesund durch die kommende Prüfungsphase zu kommen und sie in einem "10-Punkte Schlachptlan" festgehalten. Ich verabschiede mich mit dieser Folge wohl oder übel auf unbestimmte Zeit in eine Examenspause. Ob ich meine persönlichen Vorsätze halten kann und wie sich die Lage entwickelt, bleibt abzuwarten - ich werde euch bei Zeiten berichten ;) Bis dahin macht's gut und bleibt gesund. Eure Eva

This week Sam, Merel, and Shannon each individually breakdown their favorite (and least-favorite) moments of the newest season of Drive to Survive.

Join Mona and Preston as they chat with special guest, Sam, who discusses his cancer diagnosis, how he manages to stay positive, and the many things he has to look forward to as he navigates medical school. 

Here VOICE stands for Voices of Independence, Closure, and Empowerment ! This is a safe space for WOC to discuss those situations they've survived in silence. By highlighting these issues, we hope to encourage other women to share their experiences and understand that they are NOT alone. We're choosing to reveal so we can HEAL! --- Support this podcast: https://anchor.fm/mysurvivorvoice/support

Bastille lead singer, Dan Smith, joins iHeartRadio's Dave Styles, to talk about their new song "Survivin", the new EP, communicating with their fans, coloring his own hair, coping with 2020, accidently stealing my watch, and more!

Blair and Ethan talk about what to expect with a Biden presidency and how you might want to prepare now before he gets into office. Support us at patreon.com/survivalbrotherspodcast and follow us on Twitter @survbrospod. Follow us on Instagram and Parler @survivalbrotherspodcast or email us at survivalbrotherspodcast@gmail.com Thanks for listening!

Join Toni, Rico, Tenille and Terrence as we discuss trying to stay healthy and in shape during stay-at-home measures while the gyms were closed. We break down the trials and tribulations of judgement people experienced gaining weight during COVID. Many tend to eat more during times like these. We have a great discussion on online workouts options and the “weight gurus” who were successful during the pandemic. website: www.survivinthepodcast.com email: listen@survivinthepodcast facebook: Survivin' : The Podcast YouTube Channel: www.youtube.com/user/cew9040/videos

COVID Survivors speak on what it's like to endure Corona and it's many unknowns. So many rumors and folklore about COVID-19 and how to avoid being infected. No one can tell you better than a Corona survivors who lived to tell the tell. Join Matthew W., Kenny P. and I as we discuss come of the misnomers and falsehoods of experiencing COVID-19 and trying to fight it. These are their stories. website: www.survivinthepodcast.com email: listen@survivinthepodcast facebook: Survivin' : The Podcast YouTube Channel: www.youtube.com/user/cew9040/videos

Special Guest: Isidro Vasquez "Chilo"Intro song: 817 by Gente Privada Outro song: Breath by Isidro VasquezDoc sits down with old college friend Isidro Vasquez "Chilo" via Zoom from Tha Studio of Life or Death and talks Life, marriage, future fatherhood, Fort Worth Texas Livin' and Survivin', college memories, guitar tales, a passion for music, and much more. You won't want to miss this one!!! Join us Freaks and Geeks on this epic exchange of culture and experience. Follow Isidro Vasquez on instagram @el_chilovCheck his Youtube Channel LifeandtimesofisidroAlso follow his other side project Gente Privada on instagram@genteprivada817Also Be sure to Subscribe and Rate to the podcast on whatever podcast platform you enjoy the podcast on. Please follow Tha Dr on Instagram @tha512footdr and the official podcast instagram @thadrsorderspodcast.And thank you to YOU the Freaks and Geeks!!!

Yes, those are the lyrics to "I'm a Survivor" from Destiny's Child. But it is fitting considering we are discussing the greatest Survivor Series elimination matches of all time. Yes it is a long episode, but they were long matches that we reviewed. So......it's worth it. Please enjoy!

Actualidad del panorama musical, dirigido por Ana Elva Hernández. Damos la bienvenida al mes de octubre cargadas de novedades. En el programa de hoy escuchamos el bombazo que acaban de estrenar Los Invaders, "Wrong is Right". A parte, escuchamos las nuevo de Fleet Foxes, First aid Kit, Royal Blood, Sidonie, Pixies, Kurt Vile, The Crab Apples y Bastille. Además, en nuestra Sección Survivors, hablamos del Día D. Evento que tendrá lugar en la Marina Sur de Valencia el 17 de octubre y en el que podremos disfrutar de Mujers, Melenas, Belako y Cariño Escuchamos: Fleet Foxes – Can I Believe you First aid Kit – Come Give Me Love Los Invaders – Wrong is Right Royal Blood – Trouble´s Coming Sidonie – Mi vida es la Música (Con Delaporte) Pixies – Hear Me Out Kurt Vile – How Lucky The Crab Apples – Cucarachas Bastille – Survivin’ Cariño – Modo Avión Belako – Truce Mujeres - Besos En la 99.9 Valencia Radio

La nouveauté du jour : Royal Blood "Trouble's Coming" Le journal de la musique : - Supergrass va sortir un album live - Bastille relève la tête sur "Survivin'", un nouveau single plein d'espoir - Une célèbre marque de baskets de skate cherche de nouveaux talents - Les Cold war Kids annoncent 4 concerts où tout le monde peut venir La discothèque idéale du #DriveRTL2 : Depeche Mode "Music for the Masses"

Y aquí está el primer disco de Public Enemy en más de 20 años y 'GRIP' es una de las canciones incluidas junto a Cypress Hill y George Clinton. Escuchamos nueva canción de Pixies, 'Hear Me Out' y estrenamos el disco en castellano de The Grooves, un trabajo que cuenta con la producción de Juanma Latorre (Vetusta Morla) y que empieza con un grito de libertad llamado 'Todos a las Llamas'. Aparte, escuchamos lo nuevo de Bruce Springsteen y compartimos, en exclusiva, nuevo rompepistas de Los Invaders, 'Wront Is Wright'. FANTASTIC NEGRITO feat. E-40 – Searching For Captain Save A Hoe PUBLIC ENEMY feat. CYPRESS HILL & GEORGE CLINTON – GRIP ROYAL BLOOD – Trouble’s Coming AC/DC – Girls Got The Rhythm BRUNA – Hazlo Por Mí THE GROOVES – Todos a las Llamas THE CRAB APPLES – Cucarachas PIXIES – Hear Me Out TAME IMPALA – Borderline (Blood Orange Remix) THE SHINS – The Great Divide BRUCE SPRINGSTEEN – Ghosts MATT MAESON feat. LANA DEL REY – Hallucinogenics SHAMIR – Other Side IDLES – Anxiety LOS INVADERS – Wrong Is Wright BASTILLE – Survivin Escuchar audio

Este jueves nos hemos venido arriba con lo nuevo de Bastille, Fantastic Negrito, Bruna, Boy Pablo... y con 'Campos de Fresa Para Siempre' y 'Cosas Moradas', las dos canciones que nos quedaban por desvelar de 'Ya Dormiré Cuando Me Muera', el álbum de debut que mañana publican Ginebras, con quienes hablamos para que nos cuenten todos los detalles de un disco repleto de hits. BASTILLE – Survivin GRISES – Talismán THE KILLERS – Mr Brightside (Live) NIÑA POLACA – Máster en Imbécil LONDON GRAMMAR – Blinding Lights THE WEEKND – Can’t Feel My Face BOY PABLO – Leave Me Alone! GINEBRAS – Metro de Madrid Informa GINEBRAS – Campos de Fresa Para Siempre GINEBRAS – Cosas Moradas SIDONIE – Me Llamo Abba FLEET FOXES – Can I Believe It BRUNA – Hazlo Por Mí XOEL LÓPEZ – Tigre de Bengala Escuchar audio

Bastille featured on one of the biggest tunes of the last decade. They're track 'Happier' with Marshmello has over a BILLION global streams and the YouTube video views are insane (nearly 700m) while their breakout smash 'Pompeii' has over 500 million. They are global superstars now. OVER A BILLION STREAMS 'Happier' opened up a whole new audience while maintaining the loyal following of the Bastille fans who were there from the start. And now their new track Survivin is here. Dan began work on it’ months before 2020 turned on its head, intending it to be a frank account of the highs and lows of Bastille’s seven years in existence. “There’d been times when I felt like I’d been in a washing machine and on a conveyor belt at the same time,” he says, “but when people asked me how I was doing, the answer was always the British cliché: ‘Yep, all good, fine.” We can relate to the "fine" cliche in Ireland we just say "grand!" “At the start of lockdown I felt very self-conscious about having written a song that felt relevant when it wasn’t intended to be, but then I also think 2020 is the year we all stopped pretending everything’s fine.” BLUR'S GRAHAM COXON Dan tells The Fergal D'Arcy Show about making a track with Graham Coxon of Blur and how surreal it was with one of their musical heroes. Do you want to be happier? [audio mp3="https://media.radiocms.net/uploads/2020/09/23144001/DAN-BASTILLE-FULL-PODCAST.mp3"][/audio] Well, you will be after you listen to Dan Smith talking about their brand new track 'Survivin' and what it all means especially in 2020, what he has been up to in the pandemic and keeping sane, plus his 'Film Club' - he is a HUGE movie buff and has had Simon Pegg, Taiki Watiti and mores as guests on his show. Plus, he talks about meeting his hero, iconic director David Lynch. HAPPIER This track with Marshmello opened up a huge new audience of fans.  

Join Carlos, Arleita, Natasha and I as we discuss the premise of Buying Black. We dive into the basics of being a black business owner and things a consumer must know before dismissing a business because of a less than stellar experience. website: www.survivinthepodcast.com instagram: @survivin_thepodcast email: listen@survivinthepodcast facebook: Survivin' : The Podcast

Join Carlos, Arleita, Natasha and I as we discuss the premise of Buying Black. We dive into the basics of being a black business owner and things a consumer must know before dismissing a business because of a less than stellar experience. website: www.survivinthepodcast.com instagram: @survivin_thepodcast email: listen@survivinthepodcast facebook: Survivin' : The Podcast

Since we refuse to sit down and adhere to the CDC, join me as I take you on a journey for what's about to come! Also, I discuss the changes in the show and introducing live recording. website: www.survivinthepodcast.com instagram: @survivin_thepodcast email: listen@survivinthepodcast facebook: Survivin' : The Podcast

In this episode of the Epigenetics Podcast, we caught up with Professor Bill Earnshaw, Wellcome Trust Principal Research Fellow at the University of Edinburgh, to talk about his work on the role of non-histone proteins in chromosome structure and function during mitosis.   In the beginning of Bill Earnshaw's research career little was known about the structure that holds the two individual sister chromatids together. This led to Bill pioneering in the use of autoantibodies for the identification and cloning of key chromosomal proteins. He used serum from a scleroderma patient to identify and clone human centromeric proteins, which paved the way for the molecular characterization of the metazoan kinetochore.   Later the chromosomal passenger complex (CPC) was identifies in his lab using biochemical studies. This complex contains Aurora B kinase plus its targeting and regulatory subunits INCENP, Survivin, and Borealin/Dasra B.    More recently, he teamed up with the laboratories of Job Dekker and Leonid Mirny. In this collaboration they used a system for synchronous mitotic entry developed by Kumiko Samejima.These studies used a combination of chemical biology, gene targeting, Hi-C genomics, and polymer modeling to explore the roles of condensin I and condensin II in mitotic chromosome formation. The results revealed that during prophase interphase higher-order chromatin organization breaks down and subsequently condensin II and condensin I work together to form hierarchical loops that give chromosomes their compact morphology.   In this interview, we discuss the story on how centromeric proteins were first identified using sera from human scleroderma patients, how the chromosomal passenger complex was discovered, and how condensin I and II work together in chromatin loop formation.     References   Johan H. Gibcus, Kumiko Samejima, … Job Dekker (2018) A pathway for mitotic chromosome formation (Science (New York, N.Y.)) DOI: 10.1126/science.aao6135 A. F. Pluta, A. M. Mackay, … W. C. Earnshaw (1995) The Centromere: Hub of Chromosomal Activities (Science) DOI: 10.1126/science.270.5242.1591 Nuno M. C. Martins, Jan H. Bergmann, … William C. Earnshaw (2016) Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3 (Molecular Biology of the Cell) DOI: 10.1091/mbc.E15-08-0605 Oscar Molina, Giulia Vargiu, … William C. Earnshaw (2016) Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance (Nature Communications) DOI: 10.1038/ncomms13334 Jan G Ruppert, Kumiko Samejima, … William C Earnshaw (2018) HP 1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry (The EMBO Journal) DOI: 10.15252/embj.201797677   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on Linked-In Active Motif on Facebook eMail: podcast@activemotif.com

Join Miesha, Robin, Chenae and Kamisha as we discuss ways they've managed to stay sane in this 24-hour, 7 days a week environment. There is no escape, no hideout or off button. So how do you manage? Survival Tip: “Don't underestimate the silent strength you don't even know you possess.” Guest: Miesha B: @annerkey Chenae W.: @naeluv2 Kamisha K.: @kamk0714 Robin B.: @robinbirt website: www.survivinthepodcast.com instagram: @podcastsurvivin email: listen@survivinthepodcast facebook: Survivin' : The Podcast

Oncotarget - Exploring The Role Of Survivin In Neuroendocrine Neoplasms by Oncotarget Podcast

The smoke has cleared, the second ring has been disassembled, and the survivors from NXT TakeOver WarGames and Survivor Series 2019 live to wrestle another day. Matt and TL are here with full reviews of both events, as well as... Read more

It's the bye week for The Steelers so we doin something a little differently on this weeks Crowley Show as we welcome on 102.5 Afternoon Drive jock Chad Tyson to the program. We pick his brain about joining DVE, how it's a dream job for him, how many beers he puts down during Steelers games, and how long it took for him to grow that kick ass beard. Crowley has been a negative little eighth grader for most of today's show so he wants to get positive with the Pens and how hard watching Sidney Crosby makes him. He gets back into the Steelers without Tuitt before the Hottest take of the day, other crap, and the three stars of the show.

It's the bye week for The Steelers so we doin something a little differently on this weeks Crowley Show as we welcome on 102.5 Afternoon Drive jock Chad Tyson to the program. We pick his brain about joining DVE, how it's a dream job for him, how many beers he puts down during Steelers games, and how long it took for him to grow that kick ass beard. Crowley has been a negative little eighth grader for most of today's show so he wants to get positive with the Pens and how hard watching Sidney Crosby makes him. He gets back into the Steelers without Tuitt before the Hottest take of the day, other crap, and the three stars of the show.

Cardi B admits to using sex to drug and rob her johns to become a rapper --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/red-pill-man/support

This week, we’re talking about The Four Stages of Your Financial Life. In your financial life there are 15, yes count’em, 15 things that you need to do. 15 sounds daunting, doesn’t it? If you write them all down that’s not a quick post-it note, it is a full blown and hardy list. That’s why I’ve broken up your financial life into four stages for you to accomplish those 15 things in. Because how much nicer of a number does four sound than 15. Your financial life starts between the age of 18 to 22 and goes all the way until you retire around the age of 67-ish. In your financial life, you are going to work through four different stages. I like to call those: Survivin’, Drivin’, Arrivin’ and Thrivin’ (yes, I know those rhymed). Within each of those four stages I have broken up those 15 things you need to accomplish appropriately in each. When you have completed the designated set of “to-do’s” in each category, you can move onto the next the stage. Before we dive into all you need to get done, we’re going to do a little self-evaluation. If you’ve been following my blog or podcast for a while you know I’m big on the self-evaluation. It gives us a starting point. A great inside to not only where you are in your financial life, but it will tell us the stage you’re in and whether there are things you need to catch up on or plan for. In this episode I will break down each stage and the tasks they include for you to successfully, at your own pace, make it to the next stage of your financial life. You may be sitting there reading this and asking yourself, “How long does it take to make it through each stage?” Excellent question. It will be different for each individual, and that’s the beautiful thing about it. It may take a fresh college graduate who started a respectable salaried job right after school only two or three years to get out of survivin’. While it may take someone who has restarted their financial life 10 years to accomplish all the tasks in the first stage. This is where the 15 things come into role as: goals. Goals are apart of why I created these stages, to help focus on individual tasks to be accomplished. If you aren’t setting and working towards a goal(s), then you could be survivin’ for the rest of your life. You don’t want that, and I don’t want that. Focus on working towards your goals. The more your focus on them, the sooner you’ll make it through to the next. I’ll be here to help you through each and every stage along the way.

In this episode of the Brand X Podcast John, Deuce and Joe discuss: John thinks it might be time to throttle back his aggressive posture on social media. Is President Trump the Rodney Dangerfield of Presidents? Kathy Griffin tap dances after her photo shoot. Nonsense in the News Teen cuts off his own Manhood and stabs Mom over Skunk Weed Man sues dating app Grindr after 1,100 men show up expecting sex Drug Raid Live! Man who mowed lawn with tornado behind him says he 'was keeping an eye on it' 8-year-old girl disqualified from soccer game because she 'looks like a boy' We are now on Radio Vegas Rocks Thursdays 1 to 4 pm PDT Get Your Brand X Podcast Gear!! The Brand X Podcast is now a proud member of the Hush Your Face Network Podcast Shoutouts: Three is Comedy Bad Cop Bad Cop Bold and Belligerent Now That I’m Older Toe on the Trigger Ice in the Face The Story Behind WTF of Success Unwritable Rant The Tavern Podcast Horribly Awkward Podcast Horrible Gamers Podcast The Nerdowells Podcast Everyone Has A Podcast Ped and Mellor Rob and Slim The Naked Porch Who’s Right To find other great independent podcasts search the hashtag #Podernfamily and if you have a podcast you enjoy please share in Twitter, Facebook, or Instagram with #trypod. Thank you so much for listening. If you enjoyed the episode, please SUBSCRIBE on iTunes | Stitcher | Google Play | RSS and leave a rating and or review. This warms our heart and makes us smile. Please, we would love it if you joined in on the conversation! Find us on: Twitter | Facebook | Instagram Deuce on Twitter | John on Twitter  

Vivian Henry Here's another personal story of hope to help celebrate NAMI Minnesota's 40th anniversary. Vivian Henry is a NAMI "In Our Own Voice" volunteer presenter and a long-time NAMI member and supporter. Vivian enjoys photographing all of NAMI Minnesota's events and producing photo/video slide shows. Vivian is team captain of NAMIWalks 2018 team "SurVIVin the Journey!" (click for team info) You may donate to her team and/or register to join her team (you can help fund-raise even if you can't attend the walk!) at 1 of 2 links: 1. NAMIWalks-MN 9/24/17:Team Captain Viv Henry http://www.namiwalks.org/participant/VivHenry 2. Team “SurVIVin The Journey” http://www.namiwalks.org/team/SurvivinTheJourney 2012 National NAMI's "You Are Not Alone"  (click)campaign video submission via NAMI "You Are Not Alone In This Fight" campaign(2012): Vivian's Story: https://www.youtube.com/watch?v=ixEhpfBYAdw&feature=youtu.be Thank you Vivian for sharing your story with us! CONTACT US: NAMI Minnesota, www.namihelps.org, phone: 651-645-2948, toll free: 1-888-NAMI-Helps (1-888-626-4435). fax: 651-645-7379. email: namihelps@namimn.org Recorded 05/22/2017. **********  **********  ********** From Vivian...Vivian Henry's personal bio: Bio info: I'm a "small-town girl" from Xenia,OH. I survived the 1974 Xenia (F5) Tornado! My grandparents had 12 kids, and later raised me as my legal guardians. My mother Josephine battled severe BiPolar Disorder along w/other Mental Health Challenges! My Grandma Vivian was a musical prodigy! She could play piano + organ by ear! Got my love of music from her! My Grandpa James, was the 1st Black City Commissioner of Xenia, OH, and the 1st Black Mayor! My activism + humor come from him! After graduating college in 1993, I moved to MN to each elementary school. Lasted approx 7 months before my 1st severe depressive episode ended teaching career. My main work experience has been in the customer service industry, including almost 13 years as a part-time professional mobile Disc Jockey! As of 2015, I have not worked for 2 years. This is due to many of my pre-existing conditions, including Major Depression, Anxiety, Borderline Personality Disorder + recently diagnosed Attention Deficit Disorder. I'm in the midst of battling for Social Security Disability...again! Volunteered w/NAMI-MN since 2008, when I took part in my first NAMIWalks-MN! I became an "In Our Own Voice" speaker in 2014. I've done many IOOV presentations for Crisis Intervention Training, and I like working with law enforcement! Also, I'm like the unofficial amateur photographer for NAMI-MN! Love photography (massive "shutterbug"), crafts + scrapbooking, music, movies, cats, etc. Also, after I had to put my 19yr old cat to sleep on 10/10/10, I became a foster cat mom. This is how I came to adopt my amazing furbaby cat MacTavish! Unfortunately, I had to have him euthanized in November 2016. Fortunately, I do have a new cat named Precious,who is 12 years old! Love her, and no cat will ever be able to take the place of MacTavish. Finally, I've been a diehard JOURNEY fan for approximately 34 years! Have seen them in concert approximately 17x! Even flew to California in 2005, to see them receive their Hollywook Walk of Fame Star! Have had the blessings + miracles of meeting all of classic Journey (Neal Schon, Steve Perry, Steve Smith, Ross Valory + Jonathan Cain), and also Steve Augeri, Deen Castronovo, Jeff Scott Soto, and Arnel Pineda! I do believe these Journey blessings/miracles help counterbalance (a bit) my continued battles w/Mental Health Challenges! IF I won the lottery, I would become a permanent Journey concert goer, as their music brings that much joy + happiness into my life! Don't Stop Believin'! 1. YouTube Channel: luvjrny4ever 2012 National NAMI's "You Are Not Alone" campaign video submission via NAMI "You Are Not Alone In This Fight" campaign(2012): Vivian's Story.  https://www.youtube.com/watch?

Greetings ladies and gentlemen of the court. The knights are back with an old friend Circle City Hustle to discuss a few topics. In "Hustlin and Survivin" we discuss what it takes to persevere in difficult times and new surroundings. We also discuss what it means to be a "strong black woman" with Chyna.

Black History II By Craig Alexander 1h5m 1.Tonite (original) by Sai & Ribatone 2.Keeping My Composure (BPM Messing Around remix) by Dj Pope, Sheree Hicks 3.Waiting For You(Craig Alexander ChiSoul Mix) by Alton Miller 4.Escape (Tony Loreto & Mark Di Meo deep mix) by Angel A 5.Fable(Craig Alexander Lil White Lies Mix) by Lil Louis 6.Elevator(Going Up)(Dance Ritual remix)by Louie Vega, Monique Bingham 7.Sweetness In Your Soul (Louie Vega Roots NYC main)by Nathan Adams 8.Keep On (The Layabouts 2008 Regroove mix) by Dj Fudge, Mani Hoffman 9.Lake Street(2008 Mix) by Stacy Kidd 10.Survivin feat Leroy Burgess (Joey Negro club mix) by Dj Spinna 11.You Are Everything (Morales Groovy mix)by Louie Vega ,Jocelyn Brown 12.You Are Everything (Louie Vega mix)by Louie Vega .Jocelyn Brown

So That MY JOY May Be In You: “A Sons Of Thunder Mix." Spreading The Gospel in Music and Mix. Creating A Space For Believers and Seekers To Find Peace Joy Love and Freedom. Featuring The Best In Gospel House Music. 1. Children of The Underground - Oh Happy Day (Acapella) 2. Come 2Gether – Andy Holder 3. The Jersey Maestros Ft Baby Boy Steve Williams – Gotta Give Thanks 4. Ministers De-La Funk feat Jocelyn Brown – Believe 5. Joey Negro Sunburst Band (Feat Leroy Burgess)– Survivin’ 6. Mina Jackson – Pray (GHP Dub/Vocal) 7. Exodus - Together Forever 8. Drum Track – Drum Track 9. Mr. Egg Germ Featuring Janiver Jones – Holy 10. Tracks From the Other Side - Hammond Heat 11. The Windmills SA feat Mulo Blaqe – Someday (Soulplate Rerub) 12. Curtis Mayfield & The Impressions – People Get Ready 13. **Proclaimed Word: Dr. DeForest B. Soaries – “Surprised By Joy”

After being a tad poorly sick our Dai B returns to fitness..... 1. Deep South - Layo & Bushwacker 2. You Wanna Do - Crazy P 3. Survivin' (Joey Negro Boogietown Mix) - Joey Negro & The Sunburst Band 4. Back To Love (Graeme Park Remix) - Brand New Heavies 5. ????????????????????????????? 6. Plastic people - Su Su Bobien 7. Gold Bunny (Original Mix) - Toolman 8. Bad Boy - Ray Mang

The study is subdivided into two different parts: the first part deals with the development of a method to gain uterus milk in vivo during the preimplantation periode in cattle for the investigation of regulatory factors. The second part investigates different proteases in bovine follicles 20 hours after GnRH (Gonadotropin releasing hormone) injection (shortly bevor ovulation) for comparable as well as in the corpus luteum (CL) during oestrous cycle and induced luteolysis. In addition apoptotic as well as anti-apoptotic factors were evaluated in the CL during oestrous cycle and induced luteolysis. For the development of a method for gaining uterus milk in vivo during the first 24 days of gravidity in cattle, nine heifers were cycle synchronised using the Ovsynch method and artificially inseminated. Before flushing an epiduralanaesthesia was given and both uterus horns were flushed with 13ml 0.9% NaCl using a balloon embryo transfer catheter at day 5, 7, 12, 17 and 24 of gravidity. The catheter was placed 1cm cranial to the bifurcatio uteri in both horns. It was possible to retrive between 3ml and 13ml of the used flushing fluid. The uterus milk from the ipsilateral horn was inspected for an embryo and an EDTA-stabilisator was given to the uterus milk of both horns. An infection of the uterus occured in three heifers after the second and in five heifers after the third flushing. In one heifer no infection was found. Between day 17 and day 24 all heifers showed clear signs of oestrus. It was possible to detect progesterone, oestradiol-17-beta, PGF2alpha and VEGF via enzyme immunoassay (EIA) and radio immunoassay (RIA), respectively. Because of the occurred infection no statistic analysis was made. But it could be seen that the level of progesterone ranged between

Durch den Transfer tumorspezifischer T-Zellen können solide Tumore nicht nur in Tieren, sondern auch im Menschen erfolgreich behandelt werden. Dudley et al. konnten kürzlich nach dem autologen Transfer stimulierter tumorinfiltrierender Lymphozyten (TIL) nach vorheriger non-myeloablativer Konditionierung in zwei von zwölf Patienten mit Melanomen eine Tumorregression erreichen (Dudley et al. 2002). Änliche Erfolge konnten Chang et al. bei der Behandlung von fortgeschrittenen Nierenkarzinomzellen erzielen (Chang et al. 2003). Sie vakzinierten Patienten mit Calmette-Guérin Bacillus versetzten Tumorzellen und ernteten anschließend die T-Zellen aus den angrenzenden Lymphknoten der Vakzinierungsregion. Nach autologem Transfer der vorwiegend CD8+ T-Zellen, welche in vitro mit anti-CD3 stimuliert wurden, sprach die Therapie bei neun von 34 Patienten an. Die Mechanismen der T-zellvermittelten Tumorregression sind aber bis heute noch unklar. Gegenstand dieser Arbeit war es daher Faktoren zu untersuchen, welche eine Rolle bei der Regression von D5-Melanomlungenmetastasen durch den adoptiven Transfer CD4+/CD8+ T-Zellen aus Tumorvakzin drainierenden Lymphknoten (TVDLN) nach Vakzinierung mit D5G6 (einem GM-CSF transduzieren D5-Subklon) spielen. Hierzu wurden D5-Zellen in vitro mit Zytokinen, welche von Effektor T-Zellen (TE) produziert werden, stimuliert. Wir konnten zeigen, dass D5-Tumorzellen die als proapoptotisch geltenden Rezeptoren TNF-R I sowie Fas nach IFN-g-Stimulation exprimieren. Die Inkubation mit den Liganden dieser Rezeptoren TNF-a, LT-a und FasAb bewirkt keine Apoptoseinduktion. Gleichzeitige Inkubation dieser Liganden führt nur zu einer Apoptoserate von 25% in D5. Mögliche Gründe der relativen Apoptoseresistenz von D5 könnten die intrazellulären Apoptoseinhibitionsproteine c-IAP I, c-IAP II und Survivin sein, welche wir in D5 nachweisen konnten. Da nach adoptivem Transfer tumorspezifischer TE Makrophagen die pulmonalen Tumormetastasen infiltrieren, untersuchten wir, ob TE Chemokine exprimieren. Unsere Untersuchungen ergaben, dass TE die Chemokine MIP-1a, MIP-1b und RANTES tumorspezifisch exprimieren. Nach Stimulation von D5-Tumorzellen mit den Zytokinen TNF-a und IFN-g, welche von TE tumorspezifisch exprimiert werden, wird die Chemokin-mRNA von KC, MCP-1, IP-10 und Mig in D5 exprimiert. Auch die Koinkubation von D5 mit TE induziert die Expression der mRNA von KC, MCP-1, IP-10 und Mig. Deutlich erhöhte KC und MCP-1 Proteinkonzentrationen wurden im Überstand von D5-Tumorzellen mittels ELISA nach TNF-a Stimulation gegenüber unstimulierten und IFN-g stimulierten D5-Zellen festgestellt. Um zu prüfen, ob die von D5 gebildeten Substanzen auch tatsächlich chemotaktisch auf Makrophagen wirken, führten wir einen chemotaktischen Assay durch. Wir konnten zeigen, dass es zu einer signifikanten Steigerung der Anzahl migrierter Makrophagen in Richtung D5- Tumorzellen nach deren Stimulation mit IFN-g und TNF-a kommt. Da wir in TE die Expression von TNF-a-mRNA und die Sekretion von IFN-g tumorspezifisch nachweisen konnten, besteht Grund zur Annahme, dass in vivo TE in der Lage sind Tumorzellen zur Chemokinbildung anzuregen, was zu einer Invasion von Makrophagen in die Tumorregionen führt. Dass Makrophagen möglicherweise eine entscheidende Rolle bei der Tumorregression spielen, deckt sich auch mit der Beobachtung von Feinmesser et. al., welche mit einer peritumorösen Injektion von Multikinen (Zytokin-/Chemokinmischung) Kopf und Halstumore behandelten (Feinmesser et al. 2003). Nach dieser Therapie zeigte sich in den Tumorregionen der erfolgreich behandelten Patienten im Gegensatz zu Non-Respondern eine hohe Anzahl migrierter und aktivierter Makrophagen. Wir fanden mit den Ergebnissen unserer Studie erstmals Hinweise darauf, dass im murinen Melanommodell B16BL6-D5 nicht ausschließlich die direkte T-zellabhängige Zytotoxizität zur Tumorregression führt, sondern dabei weitere Zellarten wie Makrophagen/Monozyten involviert sind, welche mittels tumorspezifischer Chemokine rekrutiert werden. Die vorliegende Arbeit liefert einen Beitrag zur Erforschung der Mechanismen T-zellvermittelter Tumorregression. Die Kenntnisse dieser Mechanismen haben entscheidende Bedeutung bei der Entwicklung neuer, effektiver Behandlungskonzepte gegen solide Tumore.