Podcasts about LXR

ヒルトン、厳島神社近くにラグジュアリーホテル　2028年の開業目指す。　米・ヒルトンは12月4日、同社のラグジュアリーブランドである「LXRホテルズ&リゾーツ」のホテルを広島県廿日市市に開業すると発表した。宮島開発合同会社（東京都千代田区）が運営し、2028年の開業を目指す。

Mit etwas Delay ausgeliefert..dafür aber nen tolles Stück "Musikgeschichte", wie ich finde..:) Incl. Djuma Soundsystem, Karat, Mylo, Mish Mash, Scissor Sisters, Goldfrapp, John Dahlbäck, Feist, Sneaky Soundsystem, Lars Sommerfeld, LXR, Meteor Seven, Mike, Dark Love, Primal Scream, Starsailor, Coldplay & Synthax

Cydonia (Extended Mix)NxtxShxdxAsra Shibuya (Original Mix)Cosmonaut, K LoveskiUnivack To The Moon (Guzzk Remix)DJ Chus, Tosz, Olly KlarsStereo Productions Emi Galvan, NOIYSE PROJECT - Connection (Original Mix) Classical Plane (KAZKO Remix)Los CabraStellar Fountain No Memory (Extended Mix)Booka ShadeBlaufield Music Volar (Original Mix)Stefan Obermaier, Gonz Cabrera, Seba CamposHouse Music With Love Freaky FreakyJimmy VInterSoul Records Labyrinth (Extended Mix)Adam De Smidt, TerrasoulRound Robin Recordings Everytime I Try (Original Mix)Cevin Fisher, DJ ChusStereo Productions Play It Twice (Dilby Extended Remix)Tom Evans, Monochrome (AU), Bruno BlancValiant Isamanga (Original Mix)Lizwi, AytiwanSunset Gathering Misha_Klein_-_Love_the_Fire_(Extended_Mix)_[Headonism] Vakabular,_Under_Sanctions_-_Shankara_(Extended_Mix)_[Hollystone_Records] En CavaleBonnie SpaceyCritical Monday Muska (Original Mix)RaySooSweatbox Records Izumi (Original Mix)Marc Lenz8Bit Uninvited (feat Yasmin Jane) (Extended Mix)GinchySPRS Secret Weapon (Kiko Extended Remix)Cosmosolar, Ark NomadsLeisure Music Productions Steel Storm (Musumeci Remix)Bob Sinclar, Africanism, MoBlack, Ladysmith Black MambazoMoBlack Records Never Take You For Granted (Extended Mix)SpadaUltimo Paradiso Groove in G (Maori Remix)K2W0, DandaraMagician On Duty Stevie Nicks - Edge Of Seventeen (Samantha Loveridge Edit) Eternidad (Extended Mix)Kintar, Delum, Alex RobledoArmada Music Beauty Of Silence (RK Dious Remix)Andrea Doria, LXR aka LutzenkirchenBluFin Without A Sound (YAME Extended Remix)CIOZ, Beacon BloomUGENIUS

Dino Michael, senior vice president and global head of Hilton Luxury Brands, talks with James Shillinglaw of Insider Travel Report at last month's ILTM Cannes luxury show about how Hilton is expanding its lifestyle and luxury brands around the world. These brands include the famed Waldorf-Astoria, Conrad and LXR. For more information, visit www.hilton.com. If interested, the original video of this podcast can be found on the Insider Travel Report Youtube channel or by searching for the podcast's title on Youtube.

позитивный предновогодний настрой 1Keep U Happy (DJ Skif Remix)Thierry Tomas, Sergey SanchezHighway Records 2Letters From Home (DSF Remix)Rowee, Flowers on Monday, Eleonoraall day I dream in waves 3Children x Cola feat Mijangos (SUNANA Edit)Robert Miles x CamelPhatWhite Label 4Paris (Extended Mix)Jordan JohnSudam Recordings 5Luna (Extended Mix)Jordan JohnSudam Recordings 6Faraye (Extended Mix)Curol, Da Le (Havana)Nature Recordings 7Analog Sol - Reflections Of Rhythm - Sol Sonidos Recordings 8Beauty Of Silence (RK Dious Remix)Andrea Doria, LXR aka LutzenkirchenBluFin 9MUSIC_P,_RY.AN_-_Sherpa_(Extended_Mix)_[White_Label] 10ConnectionEmi Galvan & NOIYSE PROJECTConnection [SG101] 11Emi Galvan & NOIYSE PROJECT — Eramnesia (Original Mix) 12Cho Cho (Extended Mix)Lou BoschSKULP MUSIC 13Escape From Reality (Grigore Extended Remix)THE ILLUSTRATED MANTechnoblazer 14Magnus (Original Mix)Sam ShureHabitat Records 15There Is Hope (Original Mix)D-Nox, DJ ZombiSprout 16Love Is Real (Gina Jeanz Remix)Nanghiti, KAKI (NL)Rise Music 17Burlyaev, Godunov (KZ) - Haja (Original Mix) 18Speaker Cone Blow (Extended Mix)Croatia SquadEnormous Tunes 19Kids On Bikes (Axel Boman Remix)Nick Warren, LandikhanThe Soundgarden 20Grabbing Hands (Original Mix)Sharam Jey, Jonathan Touch, Max GazerPimp My Booty 21Only For A Moment (Extended Mix)RezidentRezident 22Maybe Yes (Extended Mix)LeharRenaissance Records 23Ajanma (Original Mix)Stan KolevOutta Limits 24Insomnia (Matt Moore Bootleg)FaithlessWhite Label

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.23.546272v1?rss=1 Authors: de la Fuente, D. C., Tamburini, C., Stonelake, E., Griffiths, W. J., Hall, J., Owen, M. J., Linden, D. E. J., Pocklington, A., Wang, Y., Li, M. Abstract: Dysregulation in neural progenitor proliferation and neuronal differentiation has been increasingly recognised as a common pathology in neural cells harboring genetic risks to neuropsychiatric and neurodevelopmental disorders, yet the underlying molecular mechanisms remains largely unknown. Deletions and duplications of the 15q11.2 region containing the CYFIP1 gene have been associated with autism and schizophrenia. Using patient-derived iPSCs carrying 15q11.2 deletion and genetically manipulated hESCs with CYFIP1 gain- and loss-of-function (GoF and LoF), we show that 15q11.2 deletion and CYFIP1-LoF leads to premature neuronal differentiation while CYFIP1-GoF favours neural progenitor maintenance. We identified cholesterol biosynthesis and metabolism as a biological process disturbed by CYFIP1 dosage change, leading to altered neuro-oxysterol profiles. 24S,25-epoxycholesterol, which was decreased in CYFIP1-GoF and increased in CYFIP1-LoF and 15q11.2del neural cells, can mimic the 15q11.2del and CYFIP1-LoF phenotype by promoting cortical neuronal differentiation and restore the impaired neuronal differentiation of CYFIP1-GoF neural progenitors. Moreover, the neurogenic activity of 24S,25-epoxycholesterol is lost following genetic deletion of the brain expressed isoform of the liver X receptor LXR{beta} while compound deletion of LXR{beta} in CYFIP1-/- background rescued their premature neurogenesis. This work delineates LXR mediated oxysterol regulation of neurogenesis as a novel pathological mechanism in neural cells carrying 15q11.2CNV and provides a potential target for therapeutic strategies for genetic disorders associated with this risk locus. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

There are high expectations for resale as pointed out by The Guardian. Next-generation customers will seek out pre-owned items that will allow the fashion industry to automatically transform a 100+ year-old linear model into a circular model. This will not happen in a straight path, nor will it happen overnight. Today, we live in the wild west, where it's hard to distinguish the positive forward momentum from the PR plays.The Fast Company article, ‘We buy too many clothes. Can fashion's secondhand boom change that?' really brings this point home. The piece starts by asking the question, despite all the resale news, “why the boom in resale isn't putting a dent in new clothing sales.” This would be like asking, despite all the eCommerce websites in 2002, why hasn't commerce changed? eCommerce has changed commerce, and resale will change new clothing production, but business model change on this scale takes time.What is more relevant is how brands are approaching the change. Fast Company spoke with Patagonia's @Asha Agrawal and Madewell's @Liz Hershfield. Agrawal points out that Patagonia must ensure that its resale platform makes money because this will allow the company to reduce the number of new products it produces while remaining a thriving business. “[Worn Wear is] already a profitable business for us. So now, it's just about scaling this business proposition, which will allow us to cut back on our net new production.”In contrast, Fast Company points out that most resale platforms don't generate revenue for brands, including ThredUp and Recurate, which helped launch resale sites for Mara Hoffman, Steve Madden, and Outerknown. Madewell's Hershfield states, “We weren't looking at profitability, but we want to break even financially. We do this to ensure we're meeting our sustainability goals.”Madewell's Forever (their resale partnership with ThredUP) is indeed good in many ways, including keeping items in use and driving customer expectations for resale. But because Madewell doesn't have a business model to make money on selling pre-owned items, Madewell isn't set up to shift its business away from a linear model. This and many other brand resale programs work in a philanthropy model rather than a business model change.The importance of a profitable business model extends beyond sustainability as more brand items are sold everywhere. EXPRESS Pre Loved, powered by LXR, quietly added 150+ luxury products to its online storefront, including Gucci, Chanel, and Louis Vuitton. EXPRESS makes it easy for their customers to shop across new and pre-owned as part of their marketplace program, including shared cart, which only 25% of brands offer today. All of this works for EXPRESS but not for the brands they now sell. The obvious risk here is that brands who never choose to sell to EXPRESS have zero control on how their items are priced, merchandise, or authenticated.Chloe made news this week by announcing it would digitally label all pieces by 2025, starting with a 20-piece capsule collection this year. As WWD reports, this part isn't new news, as many brands do this today across their full range of products. This is an essential strategy for the authenticity and future value of their products.What was more interesting, was the splashy headlines such as Vogues, Chloé launches ‘instant resale' using digital IDs on Vestiaire Collective. This is a great headline, as it speaks to the potential brands have to monetize the total value of their items. While details of the program are scarce, Vestiaire Collective may be offering immediate payout on these items rather than requiring a buyer. In this case, Vestiaire would take on the risk of the item's condition, pricing, and selling. Given this is a 1-year pilot for a capsule collection of 20 items first available in early April, we are likely talking about a handful of items ever being bought and sold in this way.Digital product IDs are an excellent move for brands. While this is a demonstration project, Chloe's direction to digitize all items by 2025 makes sense. Digital IDs have tremendous potential for brands to authenticate items and own the total value of their items. Digital IDs don't make a resale program. Brands still need to own their brand, and their customers via brand resale. Digital IDs will make that easier.The So WhatTo create more sustainable models brands need to make money selling their pre-owned items. Otherwise brand resale programs will never shift their business away from linear to circular models.Digital IDs are the future but don't change the reality that brands should not depend on anyone else to own their digital authentication keys and the resale models built on those digital IDs.

Order and disorder, a freeform haze of garbage guitars, shorted electronics, found detritus, collage, linear songs, sounds from strange lands. Contact me at btradio85@gmail.com. https://www.totallyradio.com/shows/brian-turner-overdrive for our bonus hour Brian Turner Overdrive biweekly too on Slack City UK.PLAYLIST:THE REBEL - I'm Wok Inner Gdn. C - A Cretian Build Up (Wrong Speed, 2022)SPLIT SYSTEM - The End - Vol. 1 (Legless, 2022)DAWN LOMBARDI - 02 - 04 (Sealed, 2016)FEHLFARBEN - Ein Jahr (Es Geht Voran) - 7" (Welt-Rekord/EMI Electrola, 1982)NECRONOMICON - Tips Zum Selbstmord - Tips Zum Selbstmord (1972, re: Guerssen, 2022)ERVIN BERLIN - Junior's Got Brain Damage - 7" (1980, re: Total Punk, 2022)POLUTE - Break Out - 7" (Legless, 2022)DOMINANT PATRI - Death of Thomas - Heroes Glory (1983, re: Sealed, 2022)PÖLTERWYTCH - Caskets Filled WIth Pumpkins - Count Spookula and Pölterwytch Present: The Eve of the Dead (BC, 2022)TIME (w/VELVET MACHINES) - Digital Coal Mine (Velvet Machines Facemelt Remix) - single (eMERGENCY heARTS, 2022)NBDY - Černější Než Cerná (Vokill Remix) - V/A: Vont: Rovnost Remixes (Stoned To Death, 2022)HUGJILTU - Mount Elephant - Cycle (cs, Dusty Ballz, 2022)HEINALI - Excerpt - Live From a Bomb Shelter In Ukraine (BC, 2022)ELENI POULOU - Behind the Flower (BC, 2022)UPUPAYĀMA - Sata Mi Pani - The Golden Pond (Centripetal Force, 2022)SACHIKO - Tokyo Song - 7" (LXR 1981, BC 2022)BAILTER SPACE - The Aim - Live On Mercury (BC, 2022)RICHARD EARL - Intensest Weakness - The Egg Store Ilk (Pilot, 1981)GLANDS OF EXTERNAL SECRETION - Nipping At the Potatoes of Tiberius - Neck Pillow (Siltbreeze, 2022)EVOL - Janet Planet - The Worm (Superpang, 2022)PAT METHENY - Part 4 - Zero Tolerance For Silence (Geffen, 1984)MICROWAVES - Clinical Horizon - Discomfiture Atlas (Three.One.G, 2022)ÄSS - Everybody Wants You - Live in New Jersey (cs, BaDa Bing, 2015)LADY AICHO & PISKO CRANE'S ORIGINAL FULU MIZIKI OF KINSHASA - Tikanga - N'Djila Wa Mudujimu (Nyege Nyege Tapes, 2022)BOBCAT GOLDTHWAIT INVOKES BONOGLAMOUR FOR EVENING - Why Don't You Hear Me? - V/A: Four In One (Grafika Discs, 1982)ORNETTE COLEMAN - Sleep Talk - Of Human Feelings (Antilles, 1982)HORSE LORDS - Mess Mend - Comradely Objects (RVNG Intl, 2022)JEFF CROUCH & KILLICK HINDS - Rubato Delectable - Less Continental Driftless (BC, 2022)ANDREW CHALK - At Sunset - The End Times (ICR, 2022)

Phillip Peña, Hilton Luxury Brands' managing director of luxury sales for the Americas, talks with Alan Fine of Insider Travel Report at ILTM North America about his big three luxury hotel products—Waldorf Astoria, LXR and Conrad, Peña explains the differences so travel advisors will know which of their clients should stay with which brand. He also reveals what's new and opening soon for each collection. For more information, visit www.Hilton.com, www.WaldorfAstoria.com, www.Conrad.com and lxrhotels3.hilton.com/lxr. If interested, the original video of this podcast can be found on the Insider Travel Report Youtube channel or by searching for the podcast's title on Youtube.

Episode Description In this episode of the Miles to Memories podcast we discuss Mark's recent trip to Seattle as he unnecessarily slanders some of the cities landmarks and Alaska Airlines. Along the way we learn how miles and points helped Mark to make the trip a little more comfortable. Episode Notes 7:23 - Basics of Seattle trip 10:33 - Mark's not a fan of Alaska Airlines 15:42 - Hotel 1000 LXR, A Hilton Property 21:49 - Sightseeing and touring Seattle 34:17 - Some trouble flying home Enjoying the podcast? Please consider leaving us a positive review on your favorite podcast platform! You can also connect with us anytime at podcast@milestomemories.com.  You can subscribe on Apple Podcasts, Google Play, Sticher, Spotify, TuneIn, Pocket Casts, or via RSS. Don't see your favorite podcast platform? Please let us know! Music: Rewind by Jay Someday | https://soundcloud.com/jaysomeday Music promoted by https://www.free-stock-music.com Creative Commons Attribution 3.0 Unported License

The Resale Edit: What Brands Should Consider When Building A Resale ProgramThe only place to start this week is the Charnard's decision to give 100% of Patagonia to a trust and holding company charged with manifesting Patagonia's mission: to save our home planet. There are few leaders that live their values with the willingness to discard and invent new structures for the times–Patagnoia's IronClad Guarantee, 1% for the planet, the Footprint Chronicles, Benefit Corporation, “Don't Buy This Jacket” and of course Worn Wear. Consistent with the past 50 years, Yvon and Patagonia are still willing to do so, with this recent move. Leadership can be elusive but we certainly know it when we see it. Thank you, Yvon, Milinda, Ryan, and the Patagonia team for continuing to lead.As NYFW wrapped up last week and climate week kicked off this week, Fortune points out the disagreeable truth that climate goals and big fashion business models simply do not align. Although brands and retailers are taking steps to be more sustainable, there is still a disconnect on how many goods a company can make to reach environmental goals. We are not going to address this within our current linear model. And it's one of the reasons so many fashion brands are launching resale programs. But with all these new programs how can one distinguish between business innovation and marketing? One way is to look at the business model behind the effort. Innovative business models are set up to be profit centers for the business, they address core activities such as buying and selling pre-owned items. Marketing programs have an ROI that drives traffic but are not set up to become core for the business. Saks Off 5th, who expanded their resale efforts this week with LXR and Reflaunt is aiming to make money by buying and selling pre-loved items. This is business model innovation given the ability to scale a profit center. Whereas UK fashion provider, Joules, who also announced a resale program is essentially awarding gift cards to get you back in the store, more akin to smart marketing. Marketing efforts can evolve into business innovation, but approaching resale as a business innovation certainly improves the odds of capturing the customer shift underway.Saks Off 5th initially partnered with LXR back in 2020 selling pre-owned handbags in-store. Their program has now expanded with Rent the Runway and Reflaunt to offer roughly 1,000 items online. Many of the resold items are not typically sold via the Off 5th banner including Hermes, Fendi, Prada, and Tom Ford. This makes sense for a discount retailer who can now buy back and resell higher-end pieces to their value-oriented customer base. This is a business that has the potential to continue to grow, not a marketing program.We will see more of these programs across value-oriented retailers such as Walmart, Target, JCP, and Macy's as they find new ways to attract and maintain value-oriented customers. As a not-so-small footnote, brands should beware these programs have significant brand risk in the new supply, discounting and merchandising of branded items outside the brand's purview. As compared to traditional wholesale relationships where brands share in revenue, these programs both buy from and sell to customers, bypassing the brands altogether.@James Reinhart wrote a fantastic article in Fast Company comparing fast fashion to big tobacco. James' points included the social pressures of the newest look and price point with cigarettes in the media and affordability at the time. It's possible there will be class action lawsuits or the government will regulate fast fashion but even if this does occur it won't be soon. For now, this article serves more as a billboard highlighting the need for new business models as fashion considers the sustainability implications of the industry.WWD covered lululemon's annual sustainability reporting which highlighted the challenges of our current commerce model from a CO2 perspective. Lulu shared an 82% absolute reduction, ahead of plan on direct emissions (scope 1 and 2) while indirect emissions (scope 3) increased 4%. Given lululemons growth, 4% would still be commendable by some and it also highlights the innovation needed from new business models such as lululemon's Like New. Other brands were in the news for sustainability press releases including Puma's new recycled shoe, others implementing ‘more sustainable' logistics and packing materials, and Macy's circularity program. While these make good marketing, many of these efforts, such as the process of producing a shoe from recycled content, is not addressing the systemic problem a growing fashion CO2 footprint–an exception may be Macy's move to digital samples which can scale and does address core operations. Saks Off 5th and lululemon's Like New program are examples of business innovation that can ultimately scale where business growth isn't directly tied to growing CO2 emissions.The So WhatFashion brands who are serious about climate goals will need to innovate profitable circular models. If your resale program doesn't make money buying and reselling pre-owned items, question if it's really just a marketing program and won't address your innovation agenda.Premium and luxury brands get ready for a very different retail landscape where more of your products are repurchased and resold in channels and stores you would disapprove of, bypassing you entirely. In order to control your brand, you will need ways to track and control your items beyond the first sale, owning the resale channel for your items.Week of September 23:Saks Off 5th on Resale: A Golden OpportunityWomen's Wear DailySaks Off 5th is ready to join resale. Throughout the last several months, Saks Off 5th has been partnering with companies like LXR & Co. and Rent The Runway to start building a network of pre-loved sources. Most recently, Saks Off Fifth launched with Reflaunt introducing menswear, men's accessories, footwear, and sunglasses into its roster of pre-loved merchandise. What is Driving Luxury Resale's Push into Physical Retail?The Fashion LawConsumer goods brands benefit from brick-and-mortar stores as physical retail drives higher spending, lower return rate, and acts as a better vehicle for new customer acquisitions. It's time for resale to get with the “old” way of shopping- in-store. The RealReal, Rebag, and Privè Porter plan to expand their physical store locations to achieve profitability and create the ultimate luxury experience for shoppers. Big fashion can't align its climate goals with its business modelFortuneAs the crossroads of NYFW and Climate Week meet, so does the disagreeable truth that climate goals and big fashion business models simply do not align. Although brands and retailers are taking steps to be more sustainable, there is still a disconnect on how many goods a company can make to reach environmental goals. Lululemon's Latest Impact Report Puts Pressure on Decarbonization Women's Wear Daily Lululemon has already captured the hearts of billions, $1.9 billion in quarterly revenues to be exact. The brand has made amazing strides towards becoming more sustinable, the brand still saw a 4% increase in Scope3 emissions from last year. Lululemon is now putting all of its efforts to focusing on transitioning to renewable, efficient energy. Earth is now our only shareholder.PatagoniaPatagonia is in the business of saving our home planet, by “going purpose.” Ditching the traditional route of going public, Patagonia is choosing to take its wealth and invest in the planet. 100% of the company's voting stock will transfer to Pataonia Purpose Trust and 100% of the nonvoting stock has been given to the Holdfast Collective, a nonprofit dedicated to fighting the environmental crisis and defending nature. Macy's rolls out circular servicesEcotextile NewsFor the last 18 months, Macy's has started integrating new solutions to help conquer its sustainability improvement goals. It's efforts focus on offering ethically produced products and brands to its customer base, while simultaneously reducing its environment mental impact through logistics. Salesforce Enters the Carbon-Credit BusinessThe Wall Street JournalSalesforce is entering the carbon-credit business with force as it gears up to launch it's new Net Zero Marketplace for carbon credits. The marketplace will tackle transparency and quality issues in the ever-changing field. It will launch October 9th with almost 90 projects which will support programs such as soil health and renewable energy. Why fast fashion is the next Big TobaccoFast CompanyGen Z is known as being the most eco-friendly generation yet, even though they feed into the addiction that is fast fashion more than any other consumer group. As fast fashion continues to go unchallenged, the more and more it starting to sing the same tune as Big Tobacco, especially when targeting Gen Z. Fashion brands are launching partnerships with sustainable logistics providersGlossyIn effort to support authenticity around new initiatives, retailers like Rebecca Minkoff, EB Denim and Rent the Runway are taping more sustainable shipping and packaging solutions, like Route and Olive. Route takes the heavy lifting out of the post-purchase experience by offsetting shipping emissions through integrated AI tracking parcels from retailer to customer. Ol

Today I'm sharing with you where to spend and where to save on clothing and accessories. I'm going to show you how to save money by giving you my fashion tips on spend versus save clothes and which investment pieces are worth the buy. If you want to learn where to splurge and where to save, then keep on listening because this episode is for you. Brands I like for tailoring: Anine Bing, Altuzarra, Alexander McQueen, Toteme, Marc Jacobs, Saint Laurent, Ganni, Frankie Shop, Isabel Marant, Thrifted! Brands I like for Shirting: Charvet, Anine Bing, Jacquemus, JW Anderson x Uniqlo, Sir, Alex Mill, Hommegirls Great sources for secondhand watches: The RealReal, 1stDibs, Vestiaire, Ebay, LXR&Co, Fashionphile, StockX, Chrono24 Brands I like for shoes and boots: Tamara Mellon, Prada, Paris Texas, Doc Martens, Ganni, Anine Bing, Brother Vellies, By Far Other brands I like for fancy shoes: Bottega Veneta, Gianvito Rossi, Aquazzura, Saint Laurent, Miu Miu, Balenciaga Brands I like for multi-purpose dresses: Alexander McQueen, Beaufille, Sid Neigum, Jacquemus, Tove London, Tanya Taylor, Galvan, Richard Quinn, Vintage! Brands I like for suiting: Simonett, Altuzarra, Stella McCartney, Anine Bing, Wardrobe NYC, Christopher John Rogers Indie eyewear I like: Mykita, Dita, Linda Farrow, Krewe, Lexxola, See Eyewear Brands I like for earrings: Isabel Lensee, Oscar de la Renta, JW Anderson, Beaufille, Vintage Activewear brands I like: Mate The Label, Kota, Ganni, Frankie Shop, Anine Bing, Live The Process Sneaker brands I like: Veja, New Balance, Converse Vans, never never never Golden Goose! Find me on social: Instagram: https://www.instagram.com/moshalundstrom/ TikTok: https://www.tiktok.com/@friendinfashion Website: https://www.moshalundstrom.com/ My other work: Therma Kota: https://thermakota.com/ Vogue Contributor: https://www.vogue.com/contributor/mosha-lundstrom-halbert About Me: Hello! My name is Mosha Lundström Halbert and I am a Los-Angeles based multi-disciplinary fashion director, writer, stylist, entrepreneur, and on-air personality. My work spans print, digital, radio, television, and design. I am a contributor to VOGUE.com - I edit the popular Cool Girl's Guide travel series - and I also write for a number of publications, including Cultured, The Toronto Star, and The Business of Fashion. I am a featured fashion expert on the internationally syndicated television show Cityline, and I am also the fashion contributor on CBC's q, an arts and cultural radio program that airs across Canada and the United States. Along with my mother and sister, I am also the co-founder of Therma Kota, an outerwear label inspired by my family's Nordic roots.

On today's episode of the podcast, Ryan talks to journalist and author Oliver Burkeman about his new book Four Thousand Weeks: Time Management for Mortals which releases August 10th, practicing the Stoic concept of memento mori, facing the harsh state of the reality that surrounds us, and more. Oliver Burkeman is a British journalist (principally for the British newspaper The Guardian) and writer. Between 2006 and 2020 Burkeman wrote a popular weekly column on psychology, This Column Will Change Your Life, and has reported from London, Washington and New York. He has his own blog and has published several books including The Antidote: Happiness for People Who Can't Stand Positive Thinking and HELP!: How to Become Slightly Happier and Get a Bit More DoneGet the Memento Mori Coin to remind yourself of the shortness of life: https://store.dailystoic.com/products/memento-moriThe Jordan Harbinger Show is one of the most interesting podcasts on the web, with guests like Kobe Bryant, Mark Manson, Eric Schmidt, and more. Listen to one of Ryan's episodes right now (1, 2), and subscribe to the Jordan Harbinger Show today.LMNT is the maker of electrolyte drink mixes that help you stay active at home, work, the gym, or anywhere else. Electrolytes are a key part of a happy, healthy body. As a listener of this show, you can receive a free LMNT Sample Pack for only $5 for shipping. To claim this exclusive deal you must go to drinkLMNT.com/dailystoic. If you don't love it, they will refund your $5 no questions asked.Beekeeper's Naturals is the company that's reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Visit beekeepersnaturals.com/STOIC or enter code “STOIC” to get 20% off your first order.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow us: Instagram, Twitter, YouTube, TikTok, FacebookFollow Oliver Burkeman: Homepage, Twitter See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ryan reads today's daily meditation and talks to Los Angeles Rams GM Les Snead about the cultural pillars of the Rams organization, making tough decisions under intense pressure, ignoring the short term incentives and the noise that comes along with his profession, and more.Les Snead is an American football executive who is the general manager of the Los Angeles Rams of the National Football League. Snead played tight end for Auburn from 1992-93 and was part of the Tigers' perfect 11-0 team in 1993. He also earned Southeast Region Academic All-American honors during his college career. He is in his 10th season as general manager of the Rams. Prior to joining the Rams, Snead spent 13 seasons with the Atlanta Falcons. Snead is married to Kara Henderson Snead, a sports media personality. The Jordan Harbinger Show is one of the most interesting podcasts on the web, with guests like Kobe Bryant, Mark Manson, Eric Schmidt, and more. Listen to one of Ryan's episodes right now (1, 2), and subscribe to the Jordan Harbinger Show today.LMNT is the maker of electrolyte drink mixes that help you stay active at home, work, the gym, or anywhere else. Electrolytes are a key part of a happy, healthy body. As a listener of this show, you can receive a free LMNT Sample Pack for only $5 for shipping. To claim this exclusive deal you must go to drinkLMNT.com/dailystoic. If you don't love it, they will refund your $5 no questions asked.Beekeeper's Naturals is the company that's reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Visit beekeepersnaturals.com/STOIC or enter code “STOIC” to get 20% off your first order.Magic Spoon makes delicious cereal just like you remember from when you were a kid—only this version has only 3g carbs and 11g of protein. Use code DAILYSTOIC at magicspoon.com to get free shipping. Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow us: Instagram, Twitter, YouTube, TikTok, FacebookSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week, Ryan chats with Nicolas Topiol, the CEO of Christian Lacroix. They discuss the importance of collaborations to attract a new audience, as well as the rise in demand for vintage luxury.   Topiol, who lives in Paris, Montréal and Miami,  also explains why he was "blown away" by  Québec's creativity and approach to business. Ryan's Rants & Raves is a podcast series on fashion, design and all things Québec produced by the Québec Government Office in New York and hosted by Fashion Attaché Ryan McInturf.

On today's episode of the podcast, Ryan talks to author and poet Clint Smith about his new book How the Word Is Passed: A Reckoning with the History of Slavery, the struggle to remove confederate monuments throughout the Southern United States, how to make sense of the absurd lies that have been generationally passed down since slavery was abolished, and more.Clint Smith III is an American writer, poet and scholar. He is the author of Counting Descent, a 2017 poetry collection, and How the Word Is Passed which topped The New York Times Best Seller list in June 2021. Smith received a doctorate from the Harvard Graduate School of Education.Other books mentioned on the show: Indian Givers: How Native Americans Transformed the WorldReach out to the Texas Historical Commission to help in the fight to remove the Confederate monument in Bastrop, Texas: thc.texas.gov/contact or email thc@thc.texas.govDonate to the Lockhart Texas Confederate removal campaign: https://www.gofundme.com/f/remove-the-confederate-monument-in-lockhart-txThere's only 1 day left to sign up for The Daily Stoic Leadership Challenge! It will be a masterclass in leadership with the cadence and rigor of a boot camp. It is also a live course, which means all participants will join the course together and move through together at the same pace to their own version of the same goal—to be a great leader. Registration is now officially open over at dailystoic.com/leadershipchallenge. Registration will close TONIGHT, July 31st at midnight CST.LMNT is the maker of electrolyte drink mixes that help you stay active at home, work, the gym, or anywhere else. Electrolytes are a key part of a happy, healthy body. As a listener of this show, you can receive a free LMNT Sample Pack for only $5 for shipping. To claim this exclusive deal you must go to drinkLMNT.com/dailystoic. If you don't love it, they will refund your $5 no questions asked.Beekeeper's Naturals is the company that's reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Visit beekeepersnaturals.com/STOIC or enter code “STOIC” to get 20% off your first order.Ladder makes the process of getting life insurance quick and easy. To apply, you only need a phone or laptop and a few minutes of time. Ladder's algorithms work quickly and you'll find out almost immediately if you're approved. Go to ladderlife.com/stoic to see if you're instantly approved today.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow us: Instagram, Twitter, YouTube, TikTok, FacebookFollow Clint Smith: Homepage, Instagram, Twitter, FacebookSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ryan reads today's meditation and talks to Chris Bosh about his new book Letters To A Young Athlete, how you never really “make it” in life, the importance of putting everything into what you do even when it's tough, and more. This episode was originally recorded for a Barnes and Noble Virtual Event.Chris Bosh fell in love with basketball at an early age and earned the prestigious “Mr. Basketball” title while still at Lincoln High School in Dallas, Texas. A McDonald's All-American, Bosh was selected fourth overall by the Toronto Raptors after one year attending Georgia Tech. In March 2019, Bosh's #1 jersey was officially retired for the Miami Heat. Bosh regularly speaks to youths about the benefits of reading, coding, and leadership. Bosh, his wife, Adrienne, and their five children reside in Austin, Texas.The Daily Stoic Leadership Challenge is a masterclass in leadership with the cadence and rigor of a boot camp. It is also a live course, which means all participants will join the course together and move through together at the same pace to their own version of the same goal—to be a great leader. Registration is now officially open over at dailystoic.com/leadershipchallenge. Registration will close on Saturday, July 31st at midnight CST.Beekeeper's Naturals is the company that's reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Visit beekeepersnaturals.com/STOIC or enter code “STOIC” to get 20% off your first order.The Jordan Harbinger Show is one of the most interesting podcasts on the web, with guests like Kobe Bryant, Mark Manson, Eric Schmidt, and more. Listen to one of Ryan's episodes right now (1, 2), and subscribe to the Jordan Harbinger Show today.KiwiCo believes in the power of kids and that small lessons today can mean big, world-changing ideas tomorrow. KiwiCo is a subscription service that delivers everything your kids will need to make, create and play. Get 30% off your first month plus FREE shipping on ANY crate line with code STOIC at kiwico.com. Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow us: Instagram, Twitter, YouTube, TikTok, FacebookFollow Chris Bosh: Homepage, Instagram, Twitter, Facebook, YouTubeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nueva Onda Podcast 20 - Tom Oberheim | Korg ModWave y más Hoy hablaremos de 85 años de innovación por parte de Tom Oberheim, lanzamientos como el Modwave de Korg, la caja de ritmos LXR y de un blog que se ha dedicado a hacer ingeniería inversa para emular sintes virtual analógicos de los 90's.

On today's episode, Ryan talks to journalist and author Brad Stone about his new book Amazon Unbound: Jeff Bezos and the Invention of a Global Empire, the future implications of technology guided business practices, the moral tension that arises in the midst of large scale business growth, and more. Brad Stone is the author of four books, including 2014's The Everything Store: Jeff Bezos and the Age of Amazon. He was previously a San Francisco-based correspondent for The New York Times and Newsweek. A graduate of Columbia University, he is originally from Cleveland, Ohio and lives in the San Francisco Bay Area with his wife and three daughters.Beekeeper's Naturals is the company that's reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Visit beekeepersnaturals.com/STOIC or enter code “STOIC” to get 20% off your first order.DECKED truck bed tool boxes and cargo van storage systems revolutionize organization with a heavy-duty in-vehicle storage system featuring slide out toolboxes. DECKED makes organizing, accessing, protecting, and securing everything you need so much easier. Get your DECKED Drawer System at Decked.com/STOIC and get free shipping.Athletic Greens is a custom formulation of 75 vitamins, minerals, and other whole-food sourced ingredients that make it easier for you to maintain nutrition in just a single scoop. Visit athleticgreens.com/stoic to get a FREE year supply of Liquid Vitamin D + 5 FREE Travel Packs with subscription. LinkedIn Jobs is the best platform for finding the right candidate to join your business this fall. It's the largest marketplace for job seekers in the world, and it has great search features so that you can find candidates with any hard or soft skills that you need. And now, you can post a job for free. Just visit linkedin.com/STOIC to post a job for free. Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow us: Instagram, Twitter, YouTube, TikTok, and FacebookFollow Brad Stone: Homepage, Twitter, Instagram, Facebook

Dino Michael is a global enthusiast who bubbles with ideas for his luxury Hilton-family brands, Waldorf Astoria, Conrad and LXR. Hear him now, on MARY GOSTELOW GIRLAHEAD PODCAST

On today's special episode of the podcast, Ryan talks to Dr. Edith Eger about her book The Choice: Embrace the Possible  which details her time at the Auschwitz concentration camp, the importance of feeling traumatic experiences in an effort to heal them, how suffering should lead us to strength rather than victimization, why forgiveness is a gift that you must choose to give to yourself, and more. A native of Hungary, Edith Eva Eger was just a teenager in 1944 when she experienced one of the worst evils the human race has ever known. As a Jew living in Nazi-occupied Eastern Europe, she and her family were sent to Auschwitz, the heinous death camp. Her parents were sent to the gas chambers but Edith's bravery kept her and her sister alive. Dr. Eger is a practicing psychologist and a specialist in the treatment of post-traumatic stress disorder. She is also the author of the bestselling memoir The Choice: Embrace the Possible and The Gift: 12 Lessons to Save Your Life.Beekeeper's Naturals is the company that's reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. For just $5 shipping, you can get a two-week supply of B. Immune Propolis Throat Spray for FREE. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.Ladder makes the process of getting life insurance quick and easy. To apply, you only need a phone or laptop and a few minutes of time. Ladder's algorithms work quickly and you'll find out almost immediately if you're approved. Go to ladderlife.com/stoic to see if you're instantly approved today.KiwiCo believes in the power of kids and that small lessons today can mean big, world-changing ideas tomorrow. KiwiCo is a subscription service that delivers everything your kids will need to make, create and play. Get 30% off your first month plus FREE shipping on ANY crate line with code STOIC at kiwico.com. Policygenius will help you find the insurance coverage you need. You can save 50% or more by comparing quotes. And when your life insurance policy is sorted out, you'll know that your family will be protected if anything happens. Just go to policygenius.com to get started.***Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow us:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicTikTok: https://www.tiktok.com/@daily_stoicFollow Dr. Eger:Homepage: https://dreditheger.com/Facebook: https://www.facebook.com/dredithegerTwitter: https://twitter.com/dreditheger1/ Instagram: https://www.instagram.com/dr.editheger/ 

On today’s episode of the podcast Ryan talks to author and filmmaker Sebastian Junger about his new book Freedom which details his 400 mile journey along the railroad lines of the American East Coast, the unforeseen consequences of fighting for freedom, how the fragility of life reveals a wonderment at existence, and more. Sebastian Junger is the #1 New York Times Bestselling author of The Perfect Storm and Tribe.  As an award-winning journalist, a contributing editor to Vanity Fair and a special correspondent at ABC News, he has covered major international news stories around the world. Junger is also a documentary filmmaker whose debut film "Restrepo" was nominated for an Academy Award and won the Grand Jury Prize at Sundance. GiveWell is the best site for figuring out how and where to donate your money to have the greatest impact. You can have your donation matched up to $1,000 before the end of June or as long as matching funds last. Just go to GiveWell.org/STOIC and pick podcast and The Daily Stoic at checkout. Beekeeper’s Naturals is the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.Policygenius helps you compare top insurers in one place, and it lets you save 50% or more on life insurance. Policygenius will help you find the insurance coverage you need. You can save 50% or more by comparing quotes. Just go to policygenius.com to get started.Go Macro is a family-owned maker of some of the finest protein bars around. They're vegan, non-GMO, and they come in a bunch of delicious flavors. Visit gomacro.com and use promo code STOIC for 30% off your order plus free shipping on all orders over $50.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicTikTok: https://www.tiktok.com/@daily_stoicFollow Sebastian Junger: Homepage: http://www.sebastianjunger.com/Twitter: https://twitter.com/sebastianjungerFacebook: https://www.facebook.com/sebastianjunger Instagram: https://www.instagram.com/sebastianjungerofficial/ 

Ryan reads today's Daily Stoic meditation and talks to sport psychologist and entrepreneur Dr. Michael Gervais about his work in elite performance, the practical path to excellence, how to find purpose and meaning in your life, and more.Dr. Michael Gervais is a high-performance psychologist who has worked with NFL’s Seattle Seahawks, numerous Olympic medalists, and MVPs from every major sport. Dr. Gervais is the host of the popular Finding Mastery podcast that explores the psychology of the world’s most extraordinary thinkers and doers. Dr. Gervais created an online master class for the mind and  co-authored the recently released Audible Original, Compete to Create, about how to train the mind.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is brought to you by Box of Awesome from Bespoke Post.  They have a huge number of collections no matter what you’re into: the great outdoors, style, cooking, mixology, and more. To get started, you just take a quiz at boxofawesome.com your answers help them pick the right Box of Awesome for you.Get 20% off your first monthly box when you sign up at boxofawesome.com and enter the code STOIC at checkout.This episode is also brought to you by Talkspace, the online and mobile therapy company. Talkspace lets you send and receive unlimited messages with your dedicated therapist in the Talkspace platform 24/7. To match with a licensed therapist today, go to Talkspace.com or download the app. Make sure to use the code STOIC to get $100 off of your first month and show your support for the show.Today’s episode is brought to you by Munk Pack, Keto Granola Bars that contain just a single gram of sugar and 2 to 3 net carbs—and they’re only 140 calories. Get 20% off your first purchase of ANY Munk Pack product by visiting munkpack.com and entering our code STOIC at checkout.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicTikTok: https://www.tiktok.com/@daily_stoic 

On today’s episode, Ryan talks to Lt. General H.R. McMaster about why leaders must study history and philosophy, his book Dereliction of Duty about the controversial Vietnam war, Seneca’s complicated service for the emperor Nero, and more.H.R. McMaster is a retired United States Army Lieutenant General who served as the 26th United States National Security Advisor. He is known for his roles in the Gulf War, Operation Enduring Freedom, and Operation Iraqi Freedom. His book, Battlegrounds: The Fight to Defend the Free World, was released in September 2020 and is an overview of the most critical foreign policy and national security challenges that face the United States in the modern age. This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is brought to you by Blinkist, the app that gets you fifteen-minute summaries of the best nonfiction books out there. Blinkist lets you get the topline information and the most important points from the most important nonfiction books out there, whether it’s Ryan’s own The Daily Stoic, Yuval Harari’s Sapiens, and more. Go to blinkist.com/stoic, try it free for 7 days, and save 25% off your new subscription, too.Policygenius helps you compare top insurers in one place, and it lets you save 50% or more on life insurance. Just go to policygenius.com to get started. Policygenius: when it comes to insurance, it’s nice to get it right.Today’s episode is brought to you by Munk Pack, Keto Granola Bars that contain just a single gram of sugar and 2 to 3 net carbs—and they’re only 140 calories. Get 20% off your first purchase of ANY Munk Pack product by visiting munkpack.com and entering our code STOIC at checkout.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow H.R. McMaster:Twitter: https://twitter.com/LTGHRMcMaster Instagram: https://www.instagram.com/ltghrmcmaster 

On today's episode, Ryan introduces 3 core Stoic concepts that are sure to help you through whatever life puts in front of you. The German philosopher Friedrich Nietzsche would describe his formula for human greatness as amor fati—a love of fate. Memento Mori—the ancient practice of reflection on mortality that goes back to Socrates, who said that the proper practice of philosophy is “about nothing else but dying and being dead.” The single most important practice in Stoic philosophy is differentiating between what we can change and what we can’t.This episode is also brought to you by stamps.com, a secure Internet mailing solution to print postage using your computer. Stamps.com allows you to mail and ship anytime, anywhere right from your computer. Send letters, ship packages, and pay a lot less with discounted rates from USPS, UPS, and more. There’s NO risk. Use the promo code, STOIC, to get a special offer that includes a 4-week trial PLUS free postage and a digital scale. No long-term commitments or contracts. Just go to Stamps.com, click on the Microphone at the TOP of the homepage and type in STOIC.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Beekeeper’s Naturals created a whole hive of products packed with immune-loving essentials so you can feel your best all day, every day. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is also brought to you by FitTrack, the best way to calculate your body’s composition accurately, reliably, and consistently. Every FitTrack smart scale uses advanced algorithms to offer insights into 17 different metrics indicative of bodily health. The Dara Smart Scale syncs with the free FitTrack App so all of your health insights are saved in one place. Go to fittrack.com/stoic to take 50% off your order, plus get an additional 30% with code BUILD30 at checkout. ***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoic

Ryan speaks to Gabrielle Reece about how the Stoics valued hard work, the stillness that is required to accurately observe ourselves, how to properly maintain healthy relationships and find enough for yourself, and more. Gabrielle Reece is a professional volleyball player and author of the New York Times bestseller My Foot Is Too Big for the Glass Slipper. She is also an executive member of Laird Superfood and is also the host of the Gabby Reece Show.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. For a limited time Beekeepers Naturals is offering Daily Stoic listeners an exclusive deal, receive a free B.LXR sample pack for just $5 to cover shipping. Just go to beekeepersnaturals.com/STOIC to claim this deal.Today’s episode is brought to you by Munk Pack, Keto Granola Bars that contain just a single gram of sugar and 2 to 3 net carbs—and they’re only 140 calories. They’re not just keto-friendy: they’re also gluten and grain free, plant based, and non GMO, with no soy, trans fats, sugar alcohols, or artificial coloring. Get 20% off your first purchase of ANY Munk Pack product by visiting munkpack.com and entering our code STOIC at checkout.This episode is also brought to you by FitTrack, the best way to calculate your body’s composition accurately, reliably, and consistently. Every FitTrack smart scale uses advanced algorithms to offer insights into 17 different metrics indicative of bodily health. Go to fittrack.com/stoic to take 50% off your order, plus get an additional 30% with code BUILD30 at checkout. This episode is also brought to you by Manly Bands, the best damn wedding rings period. Freedom for your hand to look like you want it to look. Whether you’re looking for men’s wedding rings or engagement rings, Manly Bands has you covered. To order your Manly Band and get 20% off, plus a free silicone ring, go to manlybands.com/stoic and enter promo code STOIC.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow Gabrielle Reece:Homepage: https://www.gabriellereece.com/ Twitter: https://twitter.com/gabbyreece Instagram: https://www.instagram.com/gabbyreece/ 

Ryan speaks to psychologist Dr. Jonathan Fader about how difficult mental preparation and training can help lead to peak performance, the unseen value of time and developing a method for clear decision making, creating a routine to create and retain gains, and more. Dr. Jonathan Fader is a licensed clinical and performance psychologist best known for working with professional athletes in the MLB and NFL. He is part of The New York City Fire Department (FDNY) Mental Performance Initiative and a frequent contributor to the national conversation on performance. He is a co-author of the book, Coaching Athletes To Be Their Best: Motivational Interviewing in Sport as well as his debut book Life as Sport. This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. For a limited time Beekeepers Naturals is offering Daily Stoic listeners an exclusive deal, receive a free B.LXR sample pack for just $5 to cover shipping. Just go to beekeepersnaturals.com/STOIC to claim this deal.This episode is also brought to you by stamps.com, a secure Internet mailing solution to print postage using your computer. Stamps.com allows you to mail and ship anytime, anywhere right from your computer. There’s NO risk. Use the promo code, STOIC, to get a special offer that includes a 4-week trial PLUS free postage and a digital scale. No long-term commitments or contracts. Just go to Stamps.com, click on the Microphone at the TOP of the homepage and type in STOIC.This episode is brought to you by LinkedIn Jobs. LinkedIn Jobs is the best platform for finding the right candidate to join your business this fall. And now, you can post a job for free. Just visit linkedin.com/STOIC to post a job for free. This episode is also brought to you by The School of Greatness podcast. Go listen to School of Greatness, it’s an amazing show and Lewis is an engaging host who really wants to help people. Subscribe to The School of Greatness on Apple Podcasts, Spotify, or visit lewishowes.com/podcast.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow Jonathan Fader:Homepage: https://jonathanfader.com/sport-psychology/ Twitter: https://twitter.com/drfader Instagram: https://www.instagram.com/jonathan_fader 

Today’s episode features another excerpt from Jeffrey Beneker’s How To Be A Leader: An Ancient Guide to Wise Leadership. How To Be A Leader is a modern translation and collection of essays about successful leadership from the ancient biographer Plutarch.Jeff Beneker is a Professor of Classics at the University of Wisconsin in Madison. His primary research interest is in Greco-Roman biography and historiography. In addition to teaching courses in Greek language and literature, he teaches lecture courses on Classical Mythology, Greco-Roman religion, and Greek civilization.This episode is brought to you by LinkedIn Jobs. LinkedIn Jobs is the best platform for finding the right candidate to join your business this fall. It’s the largest marketplace for job seekers in the world, and it has great search features so that you can find candidates with any hard or soft skills that you need. And now, you can post a job for free. Just visit linkedin.com/STOIC to post a job for free. This episode is brought to you by Public Goods, the one stop shop for sustainable, high quality everyday essentials made from clean ingredients at an affordable price. Everything from coffee to toilet paper & shampoo to pet food. Public Goods is your new everything store, thoughtfully designed for the conscious consumer. Receive $15 off your first Public Goods order with no minimum purchase. Just go to publicgoods.com/STOIC or use code STOIC at checkout.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Beekeeper’s Naturals created a whole hive of products packed with immune-loving essentials so you can feel your best all day, every day. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoic

This podcast covers CycloDextrin. It's a new medication that dissolves cholesterol crystals. And it stimulates LXR -related genes. It's actually been shown clearly in lab mouse models to dissolve plaque. It hasn't been used in humans yet. But it has been shown to stop human immune cells from attacking plaque, again by the LXR pathway. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page 

On today’s podcast, Ryan speaks to his collaborator and illustrator for his new book The Boy Who Would Be King about the process of creating the art for the book, imposing discipline on yourself, how he was impacted by Marcus Aurelius’ story, and more. Victor Juhasz is an artist and illustrator whose work has appeared in Rolling Stone, Time Magazine, and Esquire Magazine, and more. He has illustrated many books including G is for Gladiator: An Ancient Rome Alphabet and is for Zeus: A Greek Mythology Alphabet.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is also brought to you by The School of Greatness podcast. Go listen to School of Greatness, it’s an amazing show and Lewis is an engaging host who really wants to help people. Subscribe to The School of Greatness on Apple Podcasts, Spotify, or visit lewishowes.com/podcast.This episode is also brought to you by FitTrack, the best way to calculate your body’s composition accurately, reliably, and consistently. Every FitTrack smart scale uses advanced algorithms to offer insights into 17 different metrics indicative of bodily health. Go to fittrack.com/stoic to take 50% off your order, plus get an additional 30% with code BUILD30 at checkout. This episode is brought to you by Blinkist, the app that gets you fifteen-minute summaries of the best nonfiction books out there. Blinkist lets you get the topline information and the most important points from the most important nonfiction books out there, whether it’s Ryan’s own The Daily Stoic, and more. Go to blinkist.com/stoic, try it free for 7 days, and save 25% off your new subscription, too.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow Victor Juhasz:Homepage: https://juhaszillustration.com/ Twitter: https://twitter.com/juhaszillos Instagram: https://www.instagram.com/juhaszillustration

On today’s podcast, Ryan speaks to writer Allie Esiri about the Stoic’s infatuation with ancient poetry, how to read and find insight in poetry, how the greatest writing communicates to us on a subliminal level, and more. Allie Esiri is a writer and former actress in stage, film, and television. She has released several poetry anthologies including 2020’s, Shakespeare for Every Day of the Year, a collection of passages from Shakespeare's greatest works. This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is also brought to you by Public Goods, the one stop shop for sustainable, high quality everyday essentials made from clean ingredients at an affordable price. Everything from coffee to toilet paper & shampoo to pet food. Receive $15 off your first Public Goods order with no minimum purchase. Just go to publicgoods.com/STOIC or use code STOIC at checkout.This episode is also brought to you by Talkspace, the online and mobile therapy company. Talkspace lets you send and receive unlimited messages with your dedicated therapist in the Talkspace platform 24/7. To match with a licensed therapist today, go to Talkspace.com or download the app. Make sure to use the code STOIC to get $100 off of your first month and show your support for the show.This episode is also brought to you by Manly Bands, the best damn wedding rings period. Freedom for your hand to look like you want it to look. Manly Bands has an insane selection of materials: gold, wood, antler, steel, dinosaur bones, meteorite, even wood from whiskey barrels. To order your Manly Band and get 20% off, plus a free silicone ring, go to manlybands.com/stoic and enter promo code STOIC.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow Allie Esiri:Homepage: https://www.allieesiri.com/ Twitter: https://twitter.com/allieesiri Instagram: https://www.instagram.com/allieesiri/ Youtube: https://www.youtube.com/channel/UC8NUg78orDuYMW1eH2Zs-EQ

On today’s podcast, Ryan talks to World Series of Poker champion Annie Duke about making ethical choices, the overlap between Stoicism and cognitive psychology, how to objectively assess your own decisions, and more.Annie Duke is a former professional poker player and a bestselling author. She is an expert in cognitive psychology and co-founded the non-profit Ante Up for Africa in 2007 to benefit charities working in African nations. Her recent book, How To Decide, details how to be a more confident decision-maker. This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is also brought to you by Trends. Trends is the ultimate online community for entrepreneurs and business aficionados who want to know the latest news about business trends and analysis. It features articles from the most knowledgeable people, interviews with movers and shakers, and a private community of like-minded people with whom you can discuss the latest insights from Trends. Just visit trends.co/stoic to start your $1 seven day trial.This episode is also brought to you by The School of Greatness podcast. Hosted by Lewis Howes it features interviews from athletes like Kobe Bryant and Novak Djokovic, influencers like Brene Brown and Tony Robbins, authors like Robert Greene and Tim Ferriss, and more. Subscribe to The School of Greatness on Apple Podcasts, Spotify, or visit lewishowes.com/podcast.This episode is brought to you by Scribd, the e-book and audiobook subscription service that includes one million titles. Scribd uses the latest technology with the smartest people to recommend you content that you’re going to love. We’re offering listeners of The Daily Stoic a free 60 day trial. Go to try.scribd.com/stoic for your free trial. That’s try.scribd.com/stoic to get 60 days of Scribd for free.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow Annie Duke:Homepage: https://www.annieduke.com/ Twitter: https://twitter.com/annieduke YouTube: https://www.youtube.com/channel/UClDhEz5b55RH1ZfEZd7Y3hA

“You have so much to do. So much going on. There are only so many rolls of toilet paper left at the store. Only so many jobs available. Only so many kids who get accepted to the Ivy League, only so many spots on the bestseller list. So you fight. You claw. You might even kill to get what you want. What choice do you have?”Ryan explains why life is not a zero-sum game, and reads this week’s meditation from The Daily Stoic Journal, on today’s Daily Stoic Podcast.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Beekeeper’s Naturals created a whole hive of products packed with immune-loving essentials so you can feel your best all day, every day.As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow Daily Stoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoic

“It has been a series of body blows, hasn’t it? The economy. Politics. Our health. Maybe you lost your job. Maybe you’ve lost your hope. All of us are concerned. Each of us is unsure of lays in the future, and what kind of shape we’ll be in when it comes.”Ryan discusses the Stoic’s formula for endurance, and reads The Daily Stoic’s entry of the day, on today’s Daily Stoic Podcast.This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. Beekeeper’s Naturals created a whole hive of products packed with immune-loving essentials so you can feel your best all day, every day.As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow Daily Stoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoic

Ryan speaks to champion obstacle racer and attorney Amelia Boone about the absence of clear communication during the pandemic, creating structure and balance for success in multiple careers, how Stoicism offers tools to deal with our emotions, and more.Amelia Boone is a 4x world champion obstacle racer as well as a full-time practicing attorney. She is one of the most decorated obstacle racers in history and has been written about in the Wall Street Journal, Sports Illustrated, and ESPN. This episode is brought to you by Beekeeper’s Naturals, the company that’s reinventing your medicine with clean, effective products that actually work. Beekeepers Naturals has great products like Propolis Spray and B.LXR. As a listener of the Daily Stoic Podcast you can receive 15% off your first order. Just go to beekeepersnaturals.com/STOIC or use code STOIC at checkout to claim this deal.This episode is also brought to you by LinkedIn Jobs. LinkedIn Jobs is the best platform for finding the right candidate to join your business this fall. It’s the largest marketplace for job seekers in the world, and it has great search features so that you can find candidates with any hard or soft skills that you need. And now, you can post a job for free. Just visit linkedin.com/STOIC to post a job for free. This episode is also brought to you by Blinkist, the app that gets you fifteen-minute summaries of the best nonfiction books out there. Blinkist lets you get the topline information and the most important points from the most important nonfiction books out there. Go to blinkist.com/stoic, try it free for 7 days, and save 25% off your new subscription, too.This episode is also brought to you by Public Goods, the one stop shop for sustainable, high quality everyday essentials made from clean ingredients at an affordable price. Everything from coffee to toilet paper & shampoo to pet food. Public Goods is your new everything store, thoughtfully designed for the conscious consumer. Receive $15 off your first Public Goods order with no minimum purchase. Just go to publicgoods.com/STOIC or use code STOIC at checkout.***If you enjoyed this week’s podcast, we’d love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more people listen to the podcast, the more we can invest into it and make it even better.Sign up for the Daily Stoic email: http://DailyStoic.com/signupFollow @DailyStoic:Twitter: https://twitter.com/dailystoicInstagram: https://www.instagram.com/dailystoic/Facebook: http://facebook.com/dailystoicYouTube: https://www.youtube.com/dailystoicFollow Amelia Boone:Homepage: http://ameliabooneracing.com/ Twitter: https://twitter.com/ameliabooneInstagram: https://www.instagram.com/arboone11/Facebook: https://www.facebook.com/amelia.boone

Feisal Jaffer, global head of LXR Hotels & Resorts, talks with James Shillinglaw of Insider Travel Report about how LXR fits in with Hilton's other luxury brands, how many hotels and resorts it currently has in its collection, and what's on tap for expansion in 2021 and beyond. Jaffer also discussed LXR's brand attributes and what makes it different from other luxury hotels. For more information, click on LXR Hotels & Resorts. Insider Travel Report Youtube channel or by searching for the podcast's title on Youtube. 

Scott Sibella, president of Resorts World Las Vegas, talks with James Shillinglaw of Insider Travel Report about the newest mega-resort on the Strip, complete with three different Hilton branded hotels (from Hilton to Conrad to LXR), new dining concepts, a major theater, spa, pool complex, nightclub and much more—it's all coming next summer 2021. For more information, visit www.rwlasvegas.com.  Insider Travel Report Youtube channel  or by searching for the podcast's title on Youtube. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.20.256487v1?rss=1 Authors: Moldavski, O., Zushin, P.-J. H., Berdan, C. A., van Eijkeren, R. J., Jiang, X., Qian, M., Ory, D. S., Covey, D. F., Nomura, D., Stahl, A., Weiss, E., Zoncu, R. Abstract: Oxysterols are oxidized derivatives of cholesterol that play signaling roles in lipid biosynthesis and homeostasis. Here we show that 4{beta}-hydroxycholesterol (4{beta}-HC), a liver and serum abundant oxysterol of poorly defined function, is a potent and selective inducer of the master lipogenic transcription factor, Sterol Regulatory Element Binding Protein 1c (SREBP1c), but not the related steroidogenic transcription factor SREBP2. Mechanistically, 4{beta}-HC acts as a putative agonist for Liver X receptor (LXR), a sterol sensor and transcriptional regulator previously linked to SREBP1c activation. Unique among the oxysterol agonists of LXR, 4{beta}-HC induced expression of the lipogenic program downstream of SREBP1c, and triggered de novo lipogenesis both in primary hepatocytes and in mouse liver. 4{beta}-HC- acted in parallel to insulin-PI3K-dependent signaling to stimulate triglyceride synthesis and lipid droplet accumulation. Thus, 4{beta}-HC is an endogenous regulator of de novo lipogenesis through the LXR-SREBP1c axis. Copy rights belong to original authors. Visit the link for more info

Exploring the world of airport lounges. What's in them, what lounges are available for whom, and are there ways around the restrictions? Getting a Thai massage at BKK before your flight. Comfortable beds for sleeping at FRA Lufthansa HON lounge. Accessing the lounge – there are many different ways. First and business ticket holders, flight status holders, certain credit card holders. The multitude of lounges available with both airline/alliance lounges and third-party lounges. Consider opening your wallet in some cases and paying a for single entry or for an annual membership (Virgin Australia also has a lifetime membership!) Vinny somehow got into a lounge with an expired status card - and not just once or twice. The incredible Etihad Residence Lounge at AUH with a shout-out to Sam Chui for his review! And at the other end of the scale – wait until you hear about the "lounge" experience at LXR. When is it worth paying for lounge access? How a simple shower will rejuvenate you between long intercontinental flights. Don't forget about sleeping cabins and pods at some airports...are they worth it? The crazy busy SilverKris T3 lounge at SIN in the later evening...and Qantas upping their first-class lounge game at SIN by late 2019. SAS Golden Lounge at CPH – a new daylight boosting zone for those long Nordic winter nights. Cathay Pacific paid lounge access promotion at three airports flying to HKG. If you have a lounge story, question or experience that you would like to share, please email us at stories(at)seat1a.org or find us on Facebook, Twitter, Instagram and Patreon. Show notes are available online at http://podcast.seat1a.org/

Phytosterole, die Sterole von Pflanzen, unterscheiden sich von Cholesterol nur durch eine Alkylsubstitution an C24 und eventuell eine Doppelbindung in der Sterol-seitenkette. Trotz vergleichbarer Zufuhr von 200 - 600 mg/d und der großen strukturellen Ähnlichkeit werden von Phytosterolen nur 0,6 - 7%, von Cholesterol jedoch etwa 60% systemisch absorbiert. Phytosterole senken in hohen Dosen (> 2g/d) die Cholesterolabsorption um etwa 30% und die LDL-Cholesterol-Spiegel um bis zu 15% und werden deshalb zunehmend in „funktionellen Lebensmitteln“ vermarktet. Als Mechanismus wurde lange eine rein luminale, physico-chemische Interferenz mit der mizellären Emulgierung von Cholesterol postuliert. Spätestens seit der molekularen Aufklärung der Phytosterolspeicherkrankheit Sitosterolämie als dysfunktionelle Mutationen der apikalen Steroltansportproteine ABCG5/G8 stand fest, dass Phytosterole sehr wohl in Enterozyten aufgenommen, aber durch ABCG5/G8 effektiv ins Darmlumen resezerniert werden. Da ABCG5/8 auch Cholesterol transportieren kann, blieb die intestinale Sterol-Selektivität und -Interaktion weiterhin unklar. In allen Zellen wird ein Cholesterolüberschuss über bestimmte Oxycholesterole signalisiert, die den nukleären Transkriptionsfaktor LXRα aktivieren und so u.a. die Expression des zellulären Cholesterolexporters ABCA1 stimulieren. Dies ließ eine Rolle von Oxycholesterolen oder analogen regulatorischen Oxyphytosterolen bei der enterozytären Sterol-Interaktion und -Selektivität vermuten. Deshalb wurde am humanen Enterozytenmodell Caco-2 das Handling und die Metabolisierung von Phytosterolen und Cholesterol allein und in Kombination verglichen. Sitosterol wurde eindeutig, wenn auch langsamer als Cholesterol, von Enteroyzten akkumuliert, reduzierte aber bei Kombination die Cholesterolabsorption. Dies war teilweise durch Hemmung der apikalen Aufnahme, aber überwiegend der basolateralen Cholesterolsekretion bedingt, unabhängig von der Mizellenbildung, und nicht durch Sättigung einer limitierten Transportkapazität erklärbar. Im humanen Enterozyten und vergleichend in Hepatozyten und Makrophagen wurde deshalb nach potentiell regulatorischen Oxysterolen gesucht. Aus allen Sterolen wurden in diesen Zellen nur die 27-Hydroxy- und 27-Carboxy-Metaboliten gebildet, andere LXR-agonistische Oxysterole waren nicht nachweisbar. Der Umsatz war für Sitosterol und Campesterol abhängig von der Länge der C24-Alkylsubstitution deutlich geringer als für Cholesterol. In Ko-Inkubationen hemmten Phytosterole konzentrations- und C24-alkyl-abhängig die Bildung von 27-OH-Cholesterol. Diese kompetitive Hemmung und die geringe 27-Hydroxylierung von Phytosterolen selbst wurde auch in Präparationen des katalysierenden Enzyms, der an der inneren Mitochondrienwand lokalisierten Cytochrom P450 Oxidase CYP27, direkt gezeigt. Die Bioaktivität der 27-OH-Sterole als LXRα-Agonisten wurde direkt im LXRE-Transaktivierungs-Assay nachgewiesen und die stimulierte Expression von CYP27 und des in Enterozyten nur basolateral lokalisierten Cholesteroltransporters ABCA1 gezeigt. Dementsprechend steigerte 27-OH-Cholesterol auch selektiv die basolaterale, systemische Cholesterolsekretion, während der apikal exprimierte Sterolexporter ABCG8 und die apikale Sterolresekretion unverändert blieben. Umgekehrt hob in Ko- Inkubationen mit Phytosterolen die exogene Substitution eines synthetischen LXRα- Agonisten als Ersatz für das reduzierte endogene 27-OH-Cholesterol die Hemmung der Cholesterolabsorption durch Phytosterole komplett auf und überfuhr die Sterolselektivität. Auch in Tracer-Experimenten mit nanomolaren Phytosterol- und Cholesterolkonzentrationen, die die Aktivierung von LXRα nicht beeinflussen können, konnte keine direkte Sterolselektivität der ABCG5/8 und ABCA1-Transporter nachgewiesen werden. Neben physico-chemischen mizellären Effekten und der allenfalls limitierten direkten Cholesterolpräferenz der Steroltransporter NPC1L1, ABCG5/G8 und ABCA1 wurde für ACAT2, die apikal einströmendes Cholesterol zu >35% verestert und in die ApoBabhängige basolaterale Chylomikronensekretion einschleust, bereits eine relative Sterolselektivität beschrieben. Bei den eigenen Untersuchungen wurde ein neuer Mechanismus auf der regulatorischen Ebene der LXRα-Aktivierung im Enterozyten gefunden: Im Zentrum steht die kompetitive Hemmung des „Cholesterol-Sensors“ CYP27 durch Phytosterole und die nur geringe 27-Hydroxylierung der Phytosterole selbst. Dadurch wird bei gleichzeitigem Einstrom von Phytosterolen und Cholesterol in Enterozyten die Bildung des dominierenden LXRα-Agonisten 27-OH-Cholesterol verhindert. Normaler-weise vermittelt dies über LXR-Aktivierung und Induktion von CYP27, LXRα und ABCA1 eine selbstinduzierbare Komponente der Cholesterolabsorption auf dem ApoA-abhängigen Weg. Der lokale LXRα-Antagonismus von Phytosterolen blockt diese Selbstbahnung, lenkt Cholesterol vermehrt um zur luminalen Resekretion durch die konstitutiv apikal exprimierten ABCG5/8 und trägt auch zur Sterolselektivität bei. In peripheren Makrophagen könnten Phytosterole über Hemmung von CYP27, LXRα und ABCA1 durch Sterol-„Trapping“ die frühe Atherosklerose trotz eher niedriger Cholesterolspiegel bei Sitosterolämie erklären. Ob auch bei ABCG5/G8-Gesunden die unter pharmakologischen Phytosteroldosen erhöhten Plasmaspiegel langfristig zur Phytosterol- und paradoxen Cholesterol-Akkumulation in peripheren Zellen führen können, ist gegenwärtig unklar.

The liver X receptors (LXRs) have been shown to be crucially involved in maternal-fetal cholesterol transport and placentation. The aim of this study was to investigate the expression pattern and frequency of LXR under normal physiological circumstances and in spontaneous abortion and/or recurrent miscarriage. A total of 29 (12 physiologic pregnancies/10 spontaneous abortions/7 recurrent miscarriages) human pregnancies in first trimester were analysed for LXR expression. Expression changes were evaluated by immunohistochemistry for receptor and quantitative RT-PCR (TaqMan) was performed to determine the level of LXR mRNA expression. We also stained for RXR alpha and PPAR gamma as possible heterodimers of LXR. LXR expression was downregulated in the syncytiotrophoblast of spontaneous abortion placentas compared to normal pregnancy. In recurrent miscarriage there was a trend for a downregulation. Decidua showed an even stronger downregulation in both groups. In the syncytiotrophoblast we found a positive correlation for the combination of LXR/PPAR gamma in abortions and a negative correlation for LXR/RXR alpha. In addition, double-immunofluorescence staining showed that LXR as well as RXR alpha and PPAR gamma are expressed by the extravillous trophoblast. Finally, RXR alpha and LXR showed coexpression in the same extravillous trophoblast cells. To conclude, our data show that LXR expression is decreased in miscarriage.

After a short break from the podcast the show is back and set to go from strength to strength in 2010!!! Hold on for the ride! ************************************************************ This Weeks Full Show Track Listings: 1: SUNLOUNGER FT ZARA - CRAWLING 2: ANDREW DORIA & LXR – BEAUTY OF SILENCE 3: CLOU – DON'T REGRET 4: SUPAFLY INC – CATCH ME WHEN I'M FALLING (DZP VOCAL) 5: LATE NIGHT ALUMNI – YOU CAN BE THE ONE(SULTAN & NED SHEPPARD) 6: JAKE & COOPER – OVER YOU 7: TRACY THORNE – GRAND CANYON (DIRTY SOUTH) 8: FRAGMA – TOCA'S MIRACLE (INPETTO REMIX) 9: SMARTMINDS – CHOCOLATE TRUFFLES 10: SYLVIA TOSUN & LOVERUSH UK – 5 REASONS 11: CHICANE V NATASHA BEDDINGFIELD – BRUISED WATERS (MICHAEL WOODS) CATCH THE SHOWS RADIO BROADCASTS Every Tuesday at 9pm on Fuzion Radio http://www.fuzionrado.com Every Wednesday at 8pm on 1mix Radio http://www.1mix.co.uk Every Thursday at 8pm on Pure Radio http://pureradio.fm/ Every Friday at 8pm on TMRadio Russia http://www.tmradio.ru Every Friday at 9pm on Underground Flavours http://undergroundflavours.com Every Night at 9pm on Global Radio 1 http://www.globalradio1.com visit www.mattoakey.co.uk http://www.facebook.com/profile.php?id=1143302179&ref=name www.myspace.com/mattoakeydj

For their 25th anniversary, Bears Cologne was proud to offer a very special series of events. Manuel Carranco (MadBear) and DJ’s Bramsterdam and Big General played at the Butch & Bear party on Friday November 27 at Gloria. The hottest bear dance party for all butch/bear/bearded guys. Bramsterdam and Big General share their best tracks with you on Mix.dj: http://www.mix.dj/index.php?act=mlite&CODE=showdetails&s_id=37355 After playing FURBALL at Westerunie and SUPERSIZE[D] at Club Church in Amsterdam the boys are getting ready for their next parties: ANGEL CRUISE on New Year’s Eve, SUPERSIZE[D], FURBALL in Amsterdam and Sydney. Tracklist: That feeling - DJ Chus and The Groove Flauta Magica - Mark Knight & Funkagenda Slip- Deadmau5 Beatbox - Moguai Yang - Francis Preve and Wolfgang Gartner Downpipe - D. Ramirez and Mark Knight This is our night- Sander Kleinenberg Lonely- Chub and JD Davis Plastic Upgrade - Simon and Shaker Walk the line - Paul Ritch Neo - Dark Providers Discotheque - Steve Redant and Jean Philips Flashback - Calvin Harris Lamur - Guy J The beauty of silence - Andrea Doris and LXR www.weloveyourears.com

For their 25th anniversary, Bears Cologne was proud to offer a very special series of events. Manuel Carranco (MadBear) and DJ’s Bramsterdam and Big General played at the Butch & Bear party on Friday November 27 at Gloria. The hottest bear dance party for all butch/bear/bearded guys. Bramsterdam and Big General share their best tracks with you on Mix.dj: http://www.mix.dj/index.php?act=mlite&CODE=showdetails&s_id=37355 After playing FURBALL at Westerunie and SUPERSIZE[D] at Club Church in Amsterdam the boys are getting ready for their next parties: ANGEL CRUISE on New Year’s Eve, SUPERSIZE[D], FURBALL in Amsterdam and Sydney. Tracklist: That feeling - DJ Chus and The Groove Flauta Magica - Mark Knight & Funkagenda Slip- Deadmau5 Beatbox - Moguai Yang - Francis Preve and Wolfgang Gartner Downpipe - D. Ramirez and Mark Knight This is our night- Sander Kleinenberg Lonely- Chub and JD Davis Plastic Upgrade - Simon and Shaker Walk the line - Paul Ritch Neo - Dark Providers Discotheque - Steve Redant and Jean Philips Flashback - Calvin Harris Lamur - Guy J The beauty of silence - Andrea Doris and LXR www.weloveyourears.com

Hedonistic People01: Jaded - Deadmau5 - Original Mix02: Beauty Of Silence - Andrea Doria, LXR aka Lutzenkirchen - Inpetto Remix03: Coracao feat. Jaqueline - Jerry Ropero, Denis The Menace, Sabor - Club Mix04: 4 Da Underground - Cronix05: First Stroke - Swen Weber06: Touch Me - Chocolate Puma, Bingo Players - Bart B More Remix07: Europa - Pryda - Original Mix08: Cafe Del Mar - Energy 52 - Out of Office Remix09: Pjanoo - Eric Prydz - Original Mix

1. Armin Van Buuren feat. Susana – If You Should Go (Inpetto vs Duderstadt Dub Mix) 2. Gianluca Motta feat. Molly – Not Alone (Deadmau5 Remix) 3. Cerf & Mitiska – The Maze 4. Ben Macklin feat. Tiger Lily – Feel Together (Tom Novy Remix) 5. Andrea Doria, LXR – Beauty Of Silence (Inpetto [...]

01. Hooked - Love With You [Kidology]02. Phatjak - The Hatch (Sharooz mix) [Mokilok]03. Axwell, Laidback Luke, Angello, Ingrosso - Get Dumb (Mark Knight dub) [Special Project]04. LXR vs Andrea Doria - Freak Me (Dave Spoon remix) [Gut Instinct]05. Groove Armada - Get Down (Elite Force remix) [CDR]06. House Of Pain - Jump Around (Micky Slim remix) [CDR]07. D. Ramirez and Mark Knight - Colombian Soul [Toolroom]08. Phil Kieran - Skyhook [Novamute]09. Chemical Brothers - Do It Again (Oliver Huntemann remix) [CDR]10. Sebastian Leger - Saturn [Mistakes Music]11. Jaunt - Pulsar [Work It Baby]