Podcasts about nature reviews

Marketing science pioneer and UC DavisProfessor Prasad Naik reveals the power of cross-media orchestration, why mathematical models are transforming modern marketing, and why investing in your weakest media channels could be your smartest strategy.Cross Media Orchestration for Creative Excellence

Tired of getting tangled in your own words? Overcomplicating it? Asking "Does that make sense?" at the end of every sentence? Discover why you can't stop talking (even though you REALLY want to), the science behind overexplaining for perfectionists, how overexplaining is harmful to your health mentally, emotionally and physically, and why its a coping skill you want to retire ASAP.On paper, you've got it together— isn't it time you felt like it? Whether it's becoming much more DECISIVE in everything you do, stop playing out worst case scenarios in your head or becoming JOYFULLY PRESENT AMBITIOUS again, Perfectionism Optimized, private 1-1 coaching gives you the life-long skills to *finally feel* as amazing on the inside as your life looks on the outside. Get your stress-free start today at https://courtneylovegavin.com/optimized TIMESTAMPS:00:00-Understanding the Science Behind Overexplaining02:24-Why Perfectionists Are More Likely To Overexplain05:18-Control Tactics and Overexplaining08:46-Self Worth vs. Self Esteem12:32-The Emotional Charge Behind Overexplaining14:02-Toll of Overexplaining on Mental + Physical Health16:18-How Interoception Kills The Need To Overexplain20:39-TRUTH BOOTH What Overexplaining Really Is22:33-Steps to Resilience and Reducing Overexplaining Resources Mentioned In Episode 244:Perfectionism Optimized 1-1 Private CoachingImpeccable Boundaries Perfectionism Rewired Ep. 239Care-ing vs Carrying Perfectionism Rewired Ep. 202Interoception + Self-Regulation Perfectionism Rewired Ep. 194Inner Critic Be-Gone Perfectionism Rewired Ep. 212Emotional Overexplaining Perfectionism Rewired Ep. 173Proving Yourself At Work Perfectionism Rewired Ep. 232 Citations/Sources:Barrett, L. F., & Simmons, W. K. (2015). Interoceptive predictions in the brain. Nature Reviews. Neuroscience, 16(7), 419–429. https://doi.org/10.1038/nrn3950‌Price, C. J., & Hooven, C. (2018). Interoceptive Awareness Skills for Emotion Regulation: Theory and Approach of Mindful Awareness in Body-Oriented Therapy (MABT). Frontiers in Psychology, 9. https://doi.org/10.3389/fpsyg.2018.00798Ventura-Bort, C., Wendt, J., & Mathias Weymar. (2021). The Role of Interoceptive Sensibility and Emotional Conceptualization for the Experience of Emotions. Frontiers in Psychology, 12. https://doi.org/10.3389/fpsyg.2021.712418‌

This is a fascinating and complicated dive into the history behind the first placebos and observations of their effects. We'll do our best not to lose our own minds trying to sort out the complexities of the placebo effect as we understood it simply in the past, and try to contrast that with all of the newer science on the topic. This gets weird.Sources:Wikipedia: Placebo https://en.wikipedia.org/wiki/PlaceboThe Neuroscience of Placebo Effects, Nature Reviews (paywall), Wager and Atlas https://www.nature.com/articles/nrn3976The Early History of the Placebo, Jutte (paywall) https://www.sciencedirect.com/science/article/pii/S0965229912000866Attempts to Revive Antient Medical Doctrines, by Alex Sutherland (Google Books), https://www.google.com/books/edition/Attempts_to_Revive_Antient_Medical_Doctr/AntbAAAAQAAJ?hl=en&gbpv=1&pg=PP26&printsec=frontcoverPlacebo etymology, https://www.etymonline.com/word/placeboPodcast: Skeptics with a K -Episode #386 ----- Patreon Page (support the show) -----Submit a Question for Non-Medical Opinions Segment (website form with instructions)-----Podcast Linktree (social media links / reviews / ratings)-----

I det här avsnittet inleder vi i vanlig ordning med uppdatering om våra senaste bidrag till forskningsfronten. Efter det går vi in på biologisk krigföring. Från en tysk sabotageoperation på amerikanska fastlandet under första världskriget till vad ny genteknik kan innebära för hotbilden från skräddarsydda virus och bakterier. Källor: Carus, W. Seth (2017). A Short History of Biological Warfare: from Pre-History to the 21st Century. Center for the Study of Weapons of Mass Destruction, Occasional Paper 12. Washington D.C.: National Defense University PressChattopadhyay, Subhayan, Ingesson, Tony, Rinaldi, Alberto, Larsson, Oscar, Widen, J. J., Almqvist, Jessica, & Gisselsson, David (2024). "Weaponized genomics: potential threats to international and human security", Nature Reviews. Genetics, 25:1, 1-2. https://doi.org/10.1038/s41576-023-00677-8Föreläsning: Tjeckoslovakiska säkerhetstjänsten (StB) och den internationella terrorismenhttps://youtu.be/DK7i3TGNX6EIngesson Tony (2024). ”Tactical Communications and Secrecy in Contemporary Conflict: Historical and Technological Perspectives” i Hefler M. (red.) Intelligence and Contemporary Conflict: Communication in Diplomacy, Statecraft and War. Stockholm: Bokförlaget Stolpehttps://www.bokus.com/bok/9789189882157/intelligence-and-contemporary-conflict/Ingesson Tony (2024). ”Spy Hunters in a High-Trust Society: A Study of Secrecy, Suspicion, and Cooperation in Swedish Counterintelligence in the 1980s” i Vrist Rønn K, Diderichsen A, Hartmann M, Hartvigsen M (red.) Intelligence Practices in High-Trust Societies: Scandinavian Exceptionalism? Basingstoke: Routledgehttps://www.bokus.com/bok/9781032617039/intelligence-practices-in-high-trust-societies/Preston, Richard (1994). The Hot Zone: the Chilling True Story of an Ebola Outbreak. London: Transworld PublishersRichterova, Daniela (2018). ”Terrorists and Revolutionaries: The Achilles Heel of Communist Surveillance”, Surveillance & Society Vol. 16, No. 3.https://ojs.library.queensu.ca/index.php/surveillance-and-society/article/view/6958Wilkinson, Mark (2012). ”The Battle of Stalingrad, Biological Weapons, and the Expert Witness: Challenging Single-Source Evidence in Intelligence Studies”, International Journal of Intelligence and CounterIntelligence, 25:4, 795-813

Does becoming an editor mean you are leaving research? Can you ever go back to academia? And why should you "follow the cookies"? Join us as we chat with seasoned professionals who have transitioned from the lab bench to the editorial desks at Molecular Oncology, Nature Reviews and Cell. They share their personal journeys, highlight the skills necessary for this unique career path, and offer advice for researchers considering a shift into scientific publishing. Access transcripts for all our episodes at magazine.eacr.org/podcast.

On episode #58 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/20 – 7/3/24. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience) Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN) EBV and KSHV caused HIV associated cancers and lymphoproliferative disorders (Clinical Microbiology Reviews) Where in the CNS can dolutegravir, tenofovir, lamivudine and efavirenz be found? (JID) Therapeutic management of Varicella-Zoster virus meningitis (OFID) Bacterial Carbapenem use in extended-spectrum cephalosporin-resistant Enterobacterales infections (LANCET Infectious Diseases) IDSA guidelines (Columbia University) Guideline-Concordant Therapy for community-acquired pneumonia in the Hospitalized Population (OFID) Interpretive Criteria piperacillin/tazobactam susceptibility test for Enterobacterales (CID) FDA approval forCAPVAXIVE (FDA) 21 valent pneumococcal vaccine approved (Nature Reviews drug discovery) Antimicrobial resistant Staphylococcus aureus isolates (JAMA Network Open) Broad-spectrum antibiotic use for suspected community-onset sepsis (JAMA Network Open) Fungal The Last of Us ( Wikipedia) Challenges to vaccinating against coccidioidomycosis (OFID) Cryptococcosis: the story (OFID) Pneumocystis pneumonia: clinical spectrum, prophylaxis and delayed treatment (Intensive Care Medicine) Improve utilization of 1,3 β-D-glucan Testing(OFID) Music is by Ronald Jenkees

In this episode we're joined by editors from Cell, Nature Reviews and Molecular Oncology to discuss the process of scientific publishing: from the steps involved, including the peer review stage, to choosing the best home for your research; from preprints to peer-reviewed journals; from APCs and how to get a discount to the importance of engaging in an open conversation about your research with editors even prior to your paper submission.

Die einen machen es so oft wie möglich, die anderen vermeiden es, wo und wann es nur geht... Beim Telefonieren gehen die Meinungen stark auseinander. So auch bei Jannis und Luca: Während Jannis sich vornehm zurückhält, telefoniert Luca einfach drauflos. In der zweiten Folge versuchen die beiden Podcast-Palaverer eine Antwort zu finden, warum bei Jannis vor dem Telefonieren die Stresspickel sprießen und warum Bewegung beim Telefonieren guttut. Literatur ICD-10-GM-2024: F40.- Phobische Störungen - icd-code.de. (o. D.). https://www.icd code.de/icd/code/F40.-.html Hillman, C. H., Erickson, K. I. & Kramer, A. F. (2008). Be smart, exercise your heart: exercise effects on brain and cognition. Nature Reviews. Neuroscience, 9(1), 58–65. https://doi.org/10.1038/nrn2298 Hyman, I. E., Boss, S. M., Wise, B. M., McKenzie, K. E. & Caggiano, J. M. (2010). Did you see the unicycling clown? Inattentional blindness while walking and talking on a cell phone. Applied Cognitive Psychology (Print), 24(5), 597–607. https://doi.org/10.1002/acp.1638 Kupke, S. (2020). Die Angst vor dem Telefonieren wächst. https://www.forschung-und-lehre.de/zeitfragen/die-angst-vor-dem-telefonieren-waechst-2549 Stavrinos, D., Byington, K. W. & Schwebel, D. C. (2011). Distracted walking: Cell phones increase injury risk for college pedestrians. Journal Of Safety Research, 42(2), 101–107. https://doi.org/10.1016/j.jsr.2011.01.004

Efter ett långt uppehåll är vi äntligen (?) tillbaka, denna gång blir det i vanlig ordning en uppdatering om det senaste på forskningsfronten, följt av en diskussion kring scenarioanalys. Vi gör nedslag i RAND Corporation, Royal Dutch Shells banbrytande scenarioanalys från 1972 som förutspådde oljekrisen 1973, och kopplingarna till några av de moderna SAT-teknikerna. Avslutningsvis en diskussion kring de viktigaste delarna i en scenarioanalys och hur man kan använda detta som metod.Källor:Chattopadhyay, Subhayan, Ingesson, Tony, Rinaldi, Alberto, Larsson, Oscar, Widen, J. J., Almqvist, Jessica, & Gisselsson, David (2024). "Weaponized genomics: potential threats to international and human security", Nature Reviews. Genetics, 25:1, 1-2. https://doi.org/10.1038/s41576-023-00677-8Concorde: the Race for Supersonic (2023). Channel 4. https://www.channel4.com/programmes/concorde-the-race-for-supersonicIngesson, Tony & Andersson, Magnus (2024). "Clandestine Communications in Cyber-Denied Environments: Numbers stations and radio in the 21st Century", Journal of Policing, Intelligence and Counter Terrorism, 19:2, 144-165. https://www.tandfonline.com/doi/full/10.1080/18335330.2023.2209578Ingesson, Tony & Gisselsson, David (2023). "Wargaming cancer: a strategy for future precision oncology?", Trends in Cancer, 9:9, 697-699. https://www.cell.com/trends/cancer/fulltext/S2405-8033(23)00107-3#secst0005Intervjun med Randy Pherson: https://www.youtube.com/watch?v=UZmkYWvmeEEKleiner, Art (1996). The Age of Heretics. New York: DoubledaySAT-teknikerna: A Tradecraft Primer (2009). https://www.cia.gov/resources/csi/static/Tradecraft-Primer-apr09.pdf 

The liver is the primary site for drug metabolism in the body, but it can be severely damaged by medicines or their toxic compounds. Rita Baião from the North Lisbon University Hospital Center reviews what pharmacovigilance professionals should know about drug-induced liver injury (DILI).Tune in to find out:Who is most at risk of developing DILIHow to diagnose the condition and control the damageHow to assess case reports of DILIWant to know more?This infographic in Nature Reviews nicely summarises the mechanisms, diagnosis, and management of drug-induced liver injury.In this report, the Council for International Organizations of Medical Sciences provides a global perspective on DILI detection, susceptibility factors, outcomes, and more.In this Drug Safety article, industry representatives outline how to identify, mitigate, and communicate the risk of DILI during drug development. The PRO-EURO DILI NETWORK coordinates research efforts on DILI across Europe and provides a forum to exchange knowledge and training on the topic. Similar initiatives include the Spanish DILI Registry and the Latin American DILI Network.The free online tool LiverTox contains up-to-date information on drug-induced liver injury for medicines and herbal products.To learn more about post-marketing surveillance and clinical care of DILI, check out Uppsala Monitoring Centre's free online course on the topic.For more on the clustering algorithm vigiGroup, revisit this interview with UMC scientists Jim Barrett and Joe Mitchell.Join the conversation on social mediaFollow us on X, LinkedIn, or Facebook and share your thoughts about the show with the hashtag #DrugSafetyMatters.Got a story to share?We're always looking for new content and interesting people to interview. If you have a great idea for a show, get in touch!About UMCRead more about Uppsala Monitoring Centre and how we work to advance medicines safety.

La sismicità indotta è uno dei principali spauracchi legati ad alcune attività nel sottosuolo, come certe attività minerarie ed estrattive, tra cui l’iniezione di acqua per estrarne idrocarburi (il cosiddetto fracking), ma anche come alcune attività che potrebbero avere un ruolo importante nella transizione energetica, come lo stoccaggio della CO2. Nella maggioranza dei casi, i sismi generati da queste attività sono del tutto impercettibili, ma le eccezioni non mancano. Terremoti superiori al 5° grado della scala Richter sono stati registrati in più occasioni ed è quindi necessario capire meglio il fenomeno che oggi è al centro di molte ricerche di sismologia. Ne parliamo con Francesco Grìgoli - ricercatore del Dipartimento di Scienze della Terra dell’Università di Pisa - all’indomani della pubblicazione su Nature Reviews di un articolo di sintesi, che fa il punto sulle più recenti ricerche in materia.

In this episode of the MGC podcast, I talk to to Dr. Pedro Bastos, a world renowned nutritionist and researcher from Portugal, affiliated with Lund University in Sweden and the European University of Madrid, in Spain. He co-founded CEAN, a Spanish institution providing advanced education in Nutritional Sciences for health professionals. Dr. Bastos lectures globally on nutrition, lifestyle, and health in four languages, and has co-authored several scientific papers in the field in high profile journals, including Nature Medicine and Nature Reviews in Cardiology. Here are just some of the topics we address: - What is an inflammatory diet? - Chronic inflammation in the etiology of disease across the lifespan. - Pros and cons of the Mediterranean diet. - What can we learn from traditional societies. Follow Dr. Mayer: https://linktr.ee/emayer⁠

In this episode of the MGC podcast, I talk to to Dr. Pedro Bastos, a world renowned nutritionist and researcher from Portugal, affiliated with Lund University in Sweden and the European University of Madrid, in Spain. He co-founded CEAN, a Spanish institution providing advanced education in Nutritional Sciences for health professionals. Dr. Bastos lectures globally on nutrition, lifestyle, and health in four languages, and has co-authored several scientific papers in the field in high profile journals, including Nature Medicine and Nature Reviews in Cardiology. Here are just some of the topics we address: - What is an inflammatory diet? - Chronic inflammation in the etiology of disease across the lifespan. - Pros and cons of the Mediterranean diet. - What can we learn from traditional societies. Follow Dr. Mayer: https://linktr.ee/emayer⁠

Who are you? Human or a group of microbes? Mark discusses this with this with Dr. Seth Bordenstein of Penn State. Seth teaches Mark about a new word, holobiont, and the most successful pandemic in history (of invertebrates) that may help in the fight against malaria, Wolbachia! Finally, Seth discusses his team outreach efforts to teach critical thinking and STEM in students with Discover the Microbes Within. Host: Mark O. Martin Guest: Seth Bordenstein Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Maggie Middleton's (the “Vexed Muddler”)  art website. Seth Bordenstein's lab website. Discover the Microbes Within website. A useful review of the holobiont concept from the Proceedings of the National Academy of Sciences. A recent and philosophical  review of the holobiont concept from Frontiers in Psychology. Another review of the holobiont concept from the American Society for Microbiology. Wood rats, creosote, and the microbiome via Kevin Kohl in Frontiers in Microbiology. Evidence that the microbiome can impact drug effectiveness in Gut.  A review on Wolbachia and the effect it has on hosts in Nature Reviews in Microbiology. An article describing how Wolbachia can be used to fight viral diseases in Frontiers in Immunology. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

In dieser Podcastfolge habe ich mich mit Aurea Verebes getroffen. Der Schwerpunkt von Aureas Tätigkeit als Hundetrainerin liegt in der Arbeit mit Familie und Hund. Verhaltensproblemen, die im familiären Kontext auftreten, geht sie gemeinsam mit den Familien auf den Grund und begleitet Sie im Training. Aurea ist Buchautorin und Inhaberin des Verlags Canimos. Seit vielen Jahren wird der Nutzen von Schreckreizen als schnelle Verhaltenskorrektur in TV und mittlerweile auch wieder in den sozialen Medien vorgelebt. Die Nebenwirkungen sind den wenigstens Menschen jedoch bekannt. Aus einer sachlich-wissenschaftlichen Perspektive sprechen wir über Schreckreize und die Anwendung von positiven Strafen. Quellen:Vargas, M., & Doris, J. (2022). John Doris - The Oxford Handbook of Moral Psychology. Oxford University Press.Mills, D., Levine, E., Landsberg, G., & Horwitz, D. (2005). - Current Issues and Research in Veterinary behavioral Medicine. Purdue University Press.Dess, N. K., Linwick, D., Patterson, J., Overmier, J. B., & Levine, S. (1983). Immediate and proactive effects of controllability and predictability on plasma cortisol responses to shocks in dogs. Behavioral Neuroscience, 97(6), 1005–1016. Schilder, M. B. H., & van der Borg, J. A. M. (2004). Training dogs with help of the shock collar: short and long term behavioural effects. Applied Animal Behaviour Science, 85(3–4), 319–334. Hsu, Y., & Sun, L. (2010). Factors associated with aggressive responses in pet dogs. Applied Animal Behaviour Science, 123(3–4), 108–123. Seymour, B., Singer, T., & Dolan, R. (2007). The neurobiology of punishment. Nature Reviews. Neuroscience, 8(4), 300–311.Aurea Verebes findet Ihr hier:Instagram: https://www.instagram.com/aurea.verebes/Buch: https://www.canimos.de/produkt/warum-beisst-ein-hund-die-menschen-die-er-liebt/Verlag: https://www.canimos.deWenn Du aktuell Themen mit Deinem Hund hast, die Du trainieren möchtest, schreib mir einfach eine Mail an info@cintadogs.deBis bald,Cinta

Dans ce nouvel épisode de Puls'In Vet, nous plongeons dans les mystères de l'activation des neurones mécanosensoriels, les acteurs clés qui permettent de percevoir et de ressentir le monde à travers le toucher. Pour celà, je me suis penchée sur l'article "The mechanosensory neurons of touch and their mechanisms of activation" paru dans Nature Reviews en 2021. Rejoignez-nous pour explorer les subtilités de ce processus complexe et passionnant.  Que vous soyez un vétérinaire curieux de comprendre les bases de la perception tactile ou un passionné par les avancées de la neurobiologie du toucher, cet épisode vous emmènera dans un voyage captivant au cœur des mécanismes d'activation des neurones mécanosensoriels du toucher.   Restez à l'écoute de Puls'In Vet pour en découvrir encore plus ! 

In this Causes or Cures episode, Dr. Eeks chats with Dr. Shuji Ogino about his recent paper published in Nature Reviews, Clinical Oncology, titled "Is early-onset cancer an emerging global epidemic? Current evidence and future implications." In the podcast, Dr. Ogino discusses what "early onset" means, what types of cancer are showing up earlier in younger people, and the evidence and data that supports this trend. He discusses how exposures early in life and in utero may be contributing to early-onset cancer in young people ( in their thirties and forties), and the specific risk factors that have been linked to early-onset cancer.  He talks about why molecular pathological epidemiology is important for future analysis of this trend and what we need to do to slow the epidemic from an individual perspective, a public health perspective, and a research one. Dr. Ogino, originally from Japan, is chief of the program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Professor of Pathology at Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School. He is also a professor in the Department of Epidemiology at Harvard T.H. Chan School of Public Health.  You can learn more about him here. You can contact Dr. Eeks at bloomingwellness.com.Follow Dr. Eeks on Instagram here.Or Facebook here.Or Twitter.Subcribe to her newsletter here!Support the show

Olá, bio-ouvinte! Em mais um episódio da nossa minissérie "Ambientes estranhos com criaturas esquisitas", dessa vez, falamos sobre os seres vivos que vivem em condições muito diferentes do que nós poderíamos suportar, condições extremas! Vem ouvir sobre essas criaturas que vivem no (bio)limite!   Post do episódio com a TRANSCRIÇÃO   Contatos cartinhas@biologiainsitu.com.br Instagram, Facebook e LinkedIn: @biologiainsitu Twitter e TikTok: @bioinsitu   Apoio padrim.com.br/biologiainsitu Picpay: @biologiainsitu Pix: cartinhas@biologiainsitu.com.br   Créditos Pesquisa e Pauta:  Alice Saldanha, Felipe Ramos, Juliana Barbosa, Letícia Silva, Mariana dos Santos, Nadja Lopes e Viviane Turman. Coordenação de pauta: Gabriel Poccia e Vitor Lopes. Roteiro: Alice Saldanha, Gabriel Poccia e Viviane Turman. Locução: Cristianne Santos, Gabriel Oliveira e Ricardo Gomes. Convidado: Douglas Galante. Direção: Ligia Pagliotto. Edição de áudio: Ricardo Gomes. Transcrição de áudio: Bruno Santana, Cecília de Lima, Cristianne Santos, Gabriella Almeida, Karina Laskawski e Laura Batista. Este episódio usou áudios de Nerdologia, Naruto e Chapolin.   Referências utilizadas na pesquisa para esta pauta: Artigo sobre as uvas "brancas" Você sabe o que são microrganismos extremófilos? Disponível em: . Acesso em: 12 maio 2022. Tardígrados: os heróis da resistência. SoCientífica. Disponível em: . Acesso em: 12 maio 2022. SANTOS.Arqueas (Arqueobactérias). Biologia Net. Disponível em: . Acesso em: 12 maio 2022. Niederberger, T.. "archaea." Enciclopédia Britânica, 21 de outubro de 2020. https://www.britannica.com/science/archaea. Assis, SA de, Alves, DS dos S., Aires, GA, & Carvalho, SF de. (2010). Extremófilos: enzimas e aplicações industriais. SITIENTIBUS série Ciências Biológicas , 10 (2), 201–206. https://doi.org/10.13102/scb7963 Rampelotto PH. Extremófilos e ambientes extremos. Vida . 2013; 3(3):482-485. https://doi.org/10.3390/life3030482 PILLING, SERGIO.Extremófilos (tipos, propriedades, zona de habitabilidade extrema). Disponível em: https://www1.univap.br/spilling/AB/Aula_16%20Extremofilos.pdf ROMANZOTI, Natasha. Extremófilos: 8 formas de vida bizarras. HypeScience. Disponível em: . Acesso em: 12 maio 2022. Extremófilos no foco da ciência. Casa da Ciência. Disponível em: . Acesso em: 12 maio 2022. O que nos ensina a vida em ambientes extremos? - Ciência Hoje. Ciência Hoje. Disponível em: . Acesso em: 12 maio 2022. Ambiente extremo. Disponível em: . Acesso em: 12 maio 2022 Beatty, J. T; Overmann, J; Lince, M. T; Manske, A. K; Lang, A. S; Blankenship, R. E; Van Dover, C. L; Martinson, T. A; Plumley, F. G. 2005. An obligately photosynthetic bacterial anaerobe from a deep-sea hydrothermal vent. PNAS, 102(26), 9306-9310. Disponível em: *An obligately photosynthetic bacterial anaerobe from a deep-sea hydrothermal vent (pnas.org). Minic, Z; Hervé, G. 2004. Biochemical and enzymological aspects of the symbiosis between the deep-sea tubeworm Riftia pachyptila and its bacterial endosymbiont. Eur. J. Biochem, 271, 3093-3102. Disponível em: Biochemical and enzymological aspects of the symbiosis between the deep‐sea tubeworm Riftia pachyptila and its bacterial endosymbiont (wiley.com). Rocha, A. J. S; Passos, M. J. A. C. R; Monteiro, G; Ngan, P. V. 2013. O Krill da Antárica. In: Gomes, V (org). Série Conhecendo a Antártica. Instituto Oceanográfico da Universidade de São Paulo. Disponível em: VI. O krill da Antártida. - IOUSP. Acesso em: 20/05/2022. Carolina Fioratti. Fungo que evoluiu em Chernobyl é testado como escudo de radiação na Estação Espacial Internacional. Revista Super Interessante. Publicado em 24/07/2020. Disponível em: Fungo que evoluiu em Chernobyl é testado como escudo de radiação na Estação Espacial Internacional | Super (abril.com.br). Acesso em 20/05/2022. Horscroft, J. A et al. 2017. Metabolic basis to Sherpa altitude adaptation. PNAS, 114(24), 6382-6387. Disponível em:*pnas.201700527.pdf (nih.gov) Llardo, M. A et al. 2018. Physiological and genetic adaptations to diving in sea nomads. Cell, 173, 569-580. Disponível em: Physiological and Genetic Adaptations to Diving in Sea Nomads: Cell Sarah Gibbens. Bajaus são primeiros humanos geneticamente adaptados para o mergulho. National Geographic. Publicado em 23/04/2018. Disponível em: Bajaus são primeiros humanos geneticamente adaptados para mergulhar | National Geographic (nationalgeographicbrasil.com). Acesso em: 20/05/2022. Kumssa, T; Bekele, A. 2014. Current population status and activity pattern of Lesses Flamingos (Phoeniconaias minor) and Greater Flamingo (Phoenicopterus roseus) in Abijata-Shalla Lakes National Park (ASLNP), Ethiopia. International Journal of Biodiversity, 2014, 1-8. Disponível em: *295362.pdf (hindawi.com). Paul Rose. Africa's most toxic lakes are a paradise for fearless flamingos. The Converstion. Publicado em 05/01/2017. Disponível em: https://www.theconversation.com/africans-most-toxic-lakes-are-a-paradise-for-fearless-flamingos-70817. Acesso em: 20/05/2022. Belluschio, A. 2010. A hostile volcanic lake teems with life. Nature. Disponível em: https://doi.org/10.1038/news.2010.161. Acesso em: 20/05/2022. Sousa, M. B. C; Silva, H. P. A; Galvão-Coelho, N. L. 2015. Resposta ao estresse: I. homeostase e teoria da alostase. Psicobiologia e Psicologia Cognitiva, 20(1), 2-11. Disponível em: https://www.scielo.br/j/epsic/a/wLn5RGy9pVXSZKryWSPHXTF/?format=pdf&lang=pt. Babu, P; Chandel, A. K; Singh, O. V. 2015. Extremophiles and their applications in medical processes. Springer Briefs in Microbiology. 9-22. Disponível em: *Survival-Mechanisms-of-Extremophiles.pdf (researchgate.net). Gomes, E; Guez, M. A. U; Martin, N; Silva, R. 2007. Enzimas termoestáveis: fontes, produção e aplicação industrial. Quim Nova, 30(1), 136-145. Disponível em: 24-RV05423.pmd (scielo.br). 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Lead author Jeffrey Lazarus and co-author Jörn Schattenberg join Stephen Harrison, Louise Campbell, and Roger Green to discuss the groundbreaking paper "Advancing the Global Health Agenda for NAFLD." This conversation centers largely on the issues of prevalence and cost data and the challenges of explaining the impact of NAFLD to non-stakeholders before Jeff ends with a remarkable anecdote.This conversation kicks off with Stephen discussing the need for robust prevalence data. Jeff agrees but notes that past data in HIV and Hepatitis C have led to challenges and overconfidence after initial estimates were proven high. That said, Jeff notes that prevalence data will be key to accurately estimate the cost of what will be an extremely expensive disease in every world market. Louise amplifies Jeff's point on cost and Roger discusses the idea that NAFLD/NASH are different diseases at different fibrosis stages. Finally, Jeff tells a story about how all the Nature Reviews disease-specific journals coalesced around these recommendations in record time.

Lead author Jeffrey Lazarus joins the Surfers to discuss Advancing the Global Public Health Agenda for NAFLD, the major article recently published in Nature Reviews Gastroenterology and Hepatology. The article reports the results of a study with 218 Fatty Liver stakeholders in over 95 countries. Jörn Schattenberg, who participated in the entire exercise, joins Stephen Harrison, Louise Campbell and Roger Green to discuss the process, the insights and what comes next.8:55  - Jeff Lazarus begins discussion by discussing Delphi process and scope 13:13 – Jeff reports: No country scored over 50 on preparedness for the NAFLD pandemic and goes on to list the eight core issue areas for this initiative14:49 – Jörn Schattenberg discusses his reactions as a participant in the process16:29 - Stephen Harrison says clinicians will support document, then goes on to describe how healthcare practices in the US militate against thoughtful patient care18:45 – Stephen's wish: more data so we can provide stronger insights on prevalence19:55 – Jörn elaborates on how an agreed public health agenda and care models could streamline diagnostic and treatment processes20:35 – Jeff: we are a long way from strong global data…and we need that data to demonstrate the current and future cost of disease to policymakers22:22 – Stephen: we know enough today to target post-menopausal females with marginally controlled diabetes23:25 – Louise Campbell sees various systems' weaknesses and strengths as source for planning25:01 – Louise: “I can't fathom” the potential cost savings of earlier screening and treatment 25:45 – Jeff discusses his Hepatitis C experience to say “This is how we start”26:21 – Roger Green comments the dual awareness challenge: physicians do not think of NASH as even one disease when in fact it is two:  a metabolic NCD in F2 vs. serious  liver disease in F428:13 – Jeff describes the strong positive reaction of the Nature Reviews journals and others toward this paper29:15 – Jörn: this kind of awareness will help us raise public and not-for-profit funding for related research initiatives29:50 – Discussion shifts to “What comes next?”30:01 – Jeff discusses ways the collaboration continues and notes that the liver community needs allies to make this happen34:36 – Stephen: we need one messages to motivate patients to improve behavior and another to compel governments to spend 36:07 – Jeff: we need governmental structures to support individual activities36:20 – Louise: we need to increase education and focus on small behavioral steps people can achieve40:11 – Stephen's key place for impact: a simple global message for frontline providers that looks forward to when NITs become accepted and drugs are available42:44 – Roger asks how this effort relates to the US multi-specialty Clinical Care Pathways initiative 44:06 – Jeff:  Clinical Care Pathways  excellent, but we still need to focus on national health systems, sedentary lifestyle and patient education45:37 – Jeff: Center for Disease Analysis forecasts a 2x – 4x growth in NASH cirrhosis between now and 2030 in the countries they have modeled46:12 – Louise doubts our health systems can handle that kind of growth 47:48 – Jeff: cirrhosis will “sneak up” on global health authorities49:49 – Final question: one place we can have impact quickly50:02 – Jörn: working with policy makers in Germany to develop a national strategy50:26 – Louise: educating policy makers in the UK 51:18 – Roger: develop a message that conveys the "two disease" idea52:05 – Jeff:  longer term modeling to demonstrate scale of problem53:10 – Roger asks, if incidence estimates are too high, will anticipated costs scare off US and other payers54:11 – Jeff sees overestimation as a potential problem56:03 – Business section

Professor Arun Sanyal and Stephen Harrison provide a 40-minute briefing on fibroblast growth factor (FGF) agents and why they are so important to the future of NASH and NAFLD therapy. This conversation focuses on FGF drug development to date.After a simple opening from Roger Green, this conversation includes 4 key elements:1:05 - Roger Green discusses recent history of FGF agents and podcast episodes discussing them2:11 - Stephen Harrison discusses the efruxifermin BALANCED Phase 2a trial in F2/F3 NASH and Cohort C with cirrhosis patients6:59 - Arun Sanyal and Stephen Harrison discuss future prospects for FGF-21 agents10:34 - Arun Sanyal discusses specific receptor targets for different FGF agents and why they matterThis episode has specific discussions of efruxifermin and mentions of pegbelfermin and MK-3655, the former NGM-313.

Professor Arun Sanyal and Stephen Harrison provide a 40-minute briefing on fibroblast growth factor (FGF) agents and why they are so important to the future of NASH and NAFLD therapy. This conversation focuses on the roles fibroblast growth factors (FGFs) play in fat metabolism, appetite and other issues related to Fatty Liver disease. After a simple opening from Roger Green, this conversation includes 4 key elements:1:06 - Arun Sanyal discusses the different ways that fibroblast growth factors work in the body4:21 - Stephen Harrison share some background on how fat gets into the liver in the first place6:16 - Arun Sanyal describes the specific differences between FGF 2, 3 and 4 receptors in terms of physiologic impact and the role of adiponectin9:50 - Stephen Harrison and Arun Sanyal comment briefly on the impact of adiponectin in terms of liver scarring

Jeff Lazarus and Roger Green discuss the ease of creating valuable metrics in a comprehensive care model, while our three practitioners -- Stephen Harrison, Jörn Schattenberg and Louise Campbell -- dive further into how they believe this model will improve care. KEY POINT: Broadening the number and diversity of health care providers assigned to each individual patient will improve care by improving focus on the areas that count. It is important that system designers ask the right questions and answer them rigorously in context; it is undesirable for the systems to look more or less identical.

Lead author Jeffrey Lazarus and co-author Jörn Schattenberg join the Surfers to discuss how they developed the care models for their recent paper, "Defining Comprehensive Models of Care for NAFLD."The authors researched care models around the world to find the ones that work best, and then developed eight foundational recommendations for co-ordinated NAFLD care centers. In this conversation, lead author Jeff Lazarus discusses the influences on his career that converged in his decision to help shape comprehensive care models for the coming NASH pandemic. Next, co-author Jörn Schattenberg described the challenges the solo hepatologist faces when treating NASH patients today, and how this kind of comprehensive systems approach will help him offer better care.

Stephen Harrison and Louise Campbell discuss their reactions to the recent paper, "Defining Comprehensive Models of Care for NAFLD." Stephen takes the perspective of a practicing hepatologist, Louise takes the perspective of a hepatology nurse, and both come to this discussion as NASH leaders and advocates.The combination of practical patient treatment experience and passionate advocacy for NASH treatment through pharmacological and behavioral means shines through as Stephen and Louise express their enthusiasm for the comprehensive care approach and eight key elements.

Lead author Jeffrey Lazarus and co-author Jörn Schattenberg join the Surfers to discuss their recent paper, "Defining Comprehensive Models of Care for NAFLD." In this vitally important paper, the authors researched care models around the world to find the ones that work best, and then developed eight foundational recommendations for co-ordinated NAFLD care centers.Jeff Lazarus brings a career of experience in analyzing and building health systems and, separately, in viral hepatitis and HIV to exploring the challenges of the upcoming NAFLD epidemic. He invited Jörn Schattenberg, among others, to serve as the team for this project. Jeff and Jörn discuss what a systems approach to NAFLD care looks like and what each of them learned along the way. Stephen Harrison, Louise Campbell and Roger Green each brig their unique perspectives about the practice of hepatology, issues of NAFLD and general systems theory to a stimulating discussion with an array of issues and answers.

Nesse episódio, falo sobre 3 pequenos ajustes que podemos fazer na nossa rotina, super fáceis de serem implementados, mas que possuem um enorme impacto na nossa disposição, capacidade de concentração e aprendizado. Tudo baseado em (neuro)ciência!!! Deixem seus comentários, dúvidas e sugestões! CONTATO Prof. Andrei Mayer: insta: @profandrei.neuro e-mail: a.mayer@ufsc.br Como sempre, foi um prazer incomensurável! E, como prometido, segue abaixo a lista de referências: 1) Krause et al (2017) - The sleep-deprived human brain. Nature Reviews (artigo de revisão falando os vários déficits causadas pela falta de sono) https://www.nature.com/articles/nrn.2017.55 2) Van Dongen et al (2003) - The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation. SLEEP (artigo muito citado sobre o processo cumulativo do déficit de atenção causado por falta de sono) https://academic.oup.com/sleep/article/26/2/117/2709164 3) Hudson et al (2019) - Sleep deprivation, vigilant attention, and brain function: a review. Neuropsychopharmacology (artigo que também fala sobre sono, mas discute também sobre os benefício da pausa para restauração da atenção e sobre o sono local) https://www.nature.com/articles/s41386-019-0432-6 4) Schlichting and Preston (2014) - Memory reactivation during rest supports upcoming learning of related content. PNAS (exemplo de trabalho mostrando a reativação da memória durante uma pausa) https://www.pnas.org/content/111/44/15845 5) Ong et al (2019) - A daytime nap restores hippocampal function and improves declarative learning. SLEEP (artigo mostrando benefício da SONECA para memória) https://academic.oup.com/sleep/article/43/9/zsaa058/5813764

10000種類以上のmRNAをsubcellular resolutionで解析できそうなSpatial transcriptomicsの手法について、５つの原理に分けて簡単にレビュー。 Show Notes: 1. RNAのcDNAを環状にして増幅、SOLiDでin situ sequencing Highly Multiplexed Subcellular RNA Sequencing in Situ...FISSEQ。George Churchラボ。 Rolling Circle Amplification...環状にした一本鎖DNAテンプレートに対して一方向にポリメラーゼで増幅をかけ、何周もさせることにより、巨大なアンプリコンを作成する手法 Next Gen SOLiD DNA Sequencing Method Explained...SOLiDの原理説明動画。In Situ Sequencingの文脈で関連があるのは 5:18~。 Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems...Boyden+Churchラボ。UntargetedとTargetedの２種類があるが、前者はFISSEQ+ExM。後者は次の原理を利用。 Expansion microscopy...サンプルを大きくすることにより実効的な解像度を上げる手法 2. Padlock ProbeでｍRNAとDNAバーコードを対応付けてin situ sequencing Padlock Probe...末端の配列が、隣接する標的配列を持つオリゴヌクレオチド。標的配列にハイブリダイゼーションすると"ブリッジ"するような形になり、ライゲーションによって環状化できる。 In situ sequencing for RNA analysis in preserved tissue and cells...Padlock Probeを作ったMats Nillsonたちによるin situ sequencing Three-dimensional intact-tissue sequencing of single-cell transcriptional states...DeisserothラボのSTARmap。PadlockやSOLiDについて改良。 High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing...BARseq。Zadorラボ。MAPseqによって既に細胞に発現させているRNAのバーコードをpadlockに取り込み、増幅。内在性のmRNAも一緒に読める。 MAPseq...ある領域のニューロンをRNAバーコーディングし、投射先の組織からシーケンシングすることによって、個々の細胞の投射パターンを一挙に調べる手法。 3. 最初にhybridizeするプローブにバーコードの組み合わせを持たせ、更にバーコードに対するhybridizationを複数回行う Researchat #54...同じく生物学系ポッドキャスト。SeqFISH, MERFISHあたりの技術がわかりやすく解説されている。 Spatially resolved, highly multiplexed RNA profiling in single cells...MERFISH。Xiaowei Zhuangラボ。 Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH...seqFISH plus。Long Caiラボ。訂正：分離できるのは60C4個ではなく３×20^(4-1)個。 smFISH...一つのmRNAに対して何個もハイブリダイズプローブを結合させることによりシグナル増幅を行う手法 4. 座標ごとにバーコードをつけたスライドガラスに組織を貼り付ける Visualization and analysis of gene expression in tissue sections by spatial transcriptomics...Spatial Transcriptomics. Frisenラボ。 Slide-seq...Fei Chen+Macosko。Drop-seqの技術を応用。解像度10 um。 5. mRNA同士の近さをDNAで記録し、距離行列を次元削減 Researchat #16...DNA microscopy回。 DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction...Regev, Zhangラボ。Overhang PCRでmRNAの距離情報をPCR産物として記録。 A DNA nanoscope via auto-cycling proximity recording...DNA nanoscope。Yinラボ。Auto-cling proximity recordingを利用。 Nature Reviews drug discoveryによる直近のAviv Regevのインタビュー記事。 その他 EASI-FISH..,見られるmRNAの数に限りはあるが、300 um厚の切片に適用可能。 Editorial Notes: 一般にSpatial Transcriptomicsというと、マイクロダイセクションをベースとしたものや、scRNAseqのデータから座標をcomputationalに推定する、という方法も含みます。今回は１細胞解像度を担保できなさそう、ってことで割愛（宮脇） 当初このネタでポッドキャストをキックオフしようかと思っていましたが、直前にresearchatパイセンの#54を発見し、あまりにもコンセプトが被っていてかつわかりやすかったので、神経科学への応用に寄せて寄せて無事お披露目となりました汗(萩原)

Antibiotic resistance we've all heard of by now, but what about antibiotic persistence? Join us as we explore the phenomenon of persistence, which allows bacterial infections to reappear even after antibiotic treatment. And all while being genetically identical to their susceptible neighbours! Sources for this episode: 1) Balaban, N. Q., Helanie, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., Dehio, C., Fortune, S., Ghigo, J.-M., Hardt, W.-D., Harms, A., Heinemann, M., Hung, D. T., Jenal, U., Levin, B. R., Michiels, J., Storz, G., Tan, M.-W., Tenson, T., Van Melderen, L., Zinkernagel, A. (2019), Definitions and guidelines for research on antibiotic persistence. Nature Reviews 17: 441- 448. 2) Fisher, R. A., Gollan, B. and Helanie, S. (2017), Persistent bacterial infections and persister cells. Nature Reviews Microbiology 15: 453- 464. 3) Wiley, J. M., Sherwood, L. M. and Woolverton, C. J. (2017), Prescott's microbiology, 10th edition (International Edition), New York, McGraw-Hill Education. 4) Some of the discussion is based on my previous education on the topic.

Vous avez un neurone obsédé par Jennifer Aniston dans le cerveau ! Mieux que ça même, un neurone obsédé par le *concept* de Jennifer Aniston ! Merci à l'Australie de m'avoir prêté son studio pour le tournage. Ce n'est que grâce à votre soutien que je peux faire des vidéos ! Si vous aimez mon travail et souhaitez qu'il continue, n'hésitez pas à me soutenir financièrement sur uTip ou Tipeee : https://utip.io/homofabulus https://tipeee.com/homofabulus/ (Vous pouvez aussi y acheter des t-shirts et mugs stylés. Merci à toutes et tous pour votre soutien !) SOURCES : Quiroga, R. Q. (2012). Concept cells: the building blocks of declarative memory functions. Nature Reviews, 13(8), 587–597. http://doi.org/10.1038/nrn3251 Quian Quiroga, R., Reddy, L., Kreiman, G., Koch, C. & Fried, I. Invariant visual representation by single neurons in the human brain. Nature 435, 1102–1107 (2005). Sur les autres systèmes de mémorisation : McClelland, J. L., McNaughton, B. L. & O'Reilly, R. C. Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory. Psychol. Rev. 102, 419–457 (1995) O'Reilly, R. C. & Norman, K. A. Hippocampal and neocortical contributions to memory: advances in the complementary learning systems framework. Trends Cogn. Sci. 6, 505–510 (2002) Musique : Mai Tai de Jeff Kaale Facebook : https://www.facebook.com/H0moFabulus/ Twitter : http://twitter.com/homofabulus

This is an exciting and quick episode that mainly covers the findings of a recent Daniel D. Carvalho paper in Nature Reviews called “Epigenetic therapy in immune oncology” where the authors elaborate on new mechanisms of cancer treatments. Essentially, the epigenetic Cancer therapies that cause genes to reprogram the “on/off” state also awaken ancient relic viruses that lie dormant in our DNA, which subsequently leads to a massive immune response against the tumor. These mechanisms may play a role in treating aggressive forms of the disease that usually evade the immune system. Enjoy! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/keenan-t/message