Podcast appearances and mentions of dominic d agostino

This week, Dominic D'Agostino, Ph.D., joins me to explain how the brain benefits from ketosis. Dr. Dom is an Associate Professor at the University of South Florida, where he teaches at The Department of Molecular Pharmacology and Physiology and at The Morsani College of Medicine. He's also a research scientist at the Institute for Human and Machine Cognition. His work focuses on developing ways to produce therapeutic ketosis in order to prevent seizures and provide neuroprotection for people suffering from traumatic brain injuries and neurodegenerative diseases. Dr. Dom explains how the ketogenic diet helps to reduce inflammation and restore neurotransmitter and metabolic homeostasis in the brain. What's more, he reveals the reason why some people get into high levels of ketosis quickly while others struggle to increase the levels of ketones in their blood. Finally, we discuss the effect that elevated levels of ketones have on our mental clarity and athletic performance, and Dom shows us how to incorporate some level of ketosis into our daily lives through diet, intermittent fasting, and supplementation with MCTs and ketone salts.Support the show (https://www.coachjoedi.com/joe-recommends )

SHR # 2726:: Exogenous Ketones and Insulin Resistance - Dr. Dominic D'Agostino, Ph.D. - The number 1 killer of Americans is Type 2 Diabetes. Heart disease, cancer, kidney disease, high blood pressure, dementia and many more are just the results of Type 2 Diabetes. Insulin resistance is the cause of Type 2 Diabetes. When you love with elevated insulin for a long period of time you develop Type 2 Diabetes. Low to moderate levels of ketones seem to have the ability to suppress insulin response. Would exogenous ketone supplements have the ability to rescue someone from developing full-on Type 2 Diabetes? Can they also be used to help reverse Type 2 Diabetes? And if so, how should they be used?

SHR # 2726:: Exogenous Ketones and Insulin Resistance - Dr. Dominic D'Agostino, Ph.D. - The number 1 killer of Americans is Type 2 Diabetes. Heart disease, cancer, kidney disease, high blood pressure, dementia and many more are just the results of Type 2 Diabetes. Insulin resistance is the cause of Type 2 Diabetes. When you love with elevated insulin for a long period of time you develop Type 2 Diabetes. Low to moderate levels of ketones seem to have the ability to suppress insulin response. Would exogenous ketone supplements have the ability to rescue someone from developing full-on Type 2 Diabetes? Can they also be used to help reverse Type 2 Diabetes? And if so, how should they be used?

Join Lisa and Special Guest Todd White, Founder of Dry Farm Wines, for a special episode of Buddhist Biohacker. Todd has been a serial entrepreneur and creator since he was 17. Today, after 15 years in the wine business, his life is dedicated to educating and helping people make better choices about food, nutrition, and how they think about consuming alcohol. As the founder of Dry Farm Wines, a writer, speaker, and a leader in the organic/Natural Wine movement, he has widely educated communities on conscious consumption. Todd is deeply passionate about bringing people together to share love and laughter through Natural Wine. Todd is a self described biohacker who practices daily meditation, Wim Hof breathing, cold thermogenesis, a ketogenic diet, and daily 22 hour intermittent fasting. He is also a frequent speaker on topics including ketogenic lifestyle, meditation, and the Dry Farm Wines unique company culture. His entire team gathers each morning for a meditation and gratitude practice. Built on a foundation of honesty and peace, Dry Farm Wines has seen 780% growth in revenue in the last three years, making it one of the fastest growing private companies in the U.S., without any debt or investors. Dry Farm Wines is endorsed by many leading U.S. performance leaders including Mark Sisson, Dave Asprey, Ben Greenfield, Robb Wolf, Wellness Mama, Dr. Dominic D’Agostino, and Chalene Johnson, to name a few. Todd has also been the featured guest on many of these influencers’ podcasts. Dry Farm Wines is the official wine sponsor for many of the leading performance conferences worldwide, sharing over 12,000 bottles each year. Such events include Paleof(x), Joe Polish’s Genius Network Conference, LowCarbUSA, Health Optimization Summit, Metabolic Health Summit, and JJ Virgin’s Mindshare Summits. Dry Farm Wines sources pure Natural Wines and lab tests to ensure each bottle is sugar free, lower in sulfites, and lower in alcohol. The wines are friendly to low carb, Paleo, ketogenic, and low sugar diets. Dry Farm Wines is dedicated to supporting small natural growers, currently sourcing from 600 family farmers who preserve 87,000 acres of organic vineyards and save 1.4 billion gallons of water annually by not irrigating their vines. They vet each grower’s practice and support those who focus on regenerative farming, biodiversity, hand harvesting, and the absence of industrial additives. Dry Farm Wines is proud to be the largest Natural Wine merchant in the world, bringing awareness to Natural Wine consumption and supporting farmers who honor the soil. To order your own Dry Farm Wine: https://www.dryfarmwines.com/?rfsn=35...

Dominic is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). And today, he’s back on the H.V.M.N. podcast to discuss the latest science on ketogenic diet and human metabolism. Key point topics and studies mentioned: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis -https://www.nature.com/articles/s41392-020-00411-4 The falling heart utilizes 3-hydroxybutyrate as a metabolic stress defense - https://pubmed.ncbi.nlm.nih.gov/30668551/ Metabolic Health Summit Exogenous Ketones Oxidized LDL Metabolic flexibility for Covid H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans and we want to give you a special reward. Use GEOFF10 to get 10% off your KFB order: https://hvmn.com/discount/GEOFF10 Learn More About H.V.M.N. here: https://hvmn.com/pod Join the Official H.V.M.N. Podcast Discord Community by filling out this quick survey: https://go.hvmn.com/discordsurvey Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions!

bengreenfieldfitness.com/energyformula If there's anything people say they want more of these days...it's energy. The world around us continually requires more from us while we give less and less thought to our long-term health. This distracted and overwhelmed mindset has landed us squarely in survival mode, depriving us of the necessary steps to create lasting, sustained energy. The truth is most of us are so exhausted and don't know how to find the energy to live our best lives. My friend Shawn Wells just put the finishing touches on his new book The ENERGY Formula: Six Life Changing Ingredients to Unleash Your Limitless Potential... ...which covers keto, Paleo, biohacking, stoicism, supplements, CBD, nootropics, MCTs, infrared saunas, cold plunges, how to create a sleep fortress, circadian rhythm, and much more. With about 60 full-color diagrams and over 100 scientific citations, Shawn gives you the knowledge you will not find anywhere else, including "Formulator's Corners" in every chapter that cover doses, brands, and forms of supplements you need to be taking as well as "Resource Hacks" that tell you the products, devices, apps, and more to use. Developed by biochemist, dietitian, sports nutritionist, and formulation scientist Shawn Wells after surviving a series of torturous health battles, this pivotal and groundbreaking book is the product of meticulous and persistent research to find solutions to his personal and painful experiences—paired with two decades of legitimate clinical and scientific expertise. Shawn previously joined me on the podcast episode "The Nitty-Gritty Underground World of Supplement Ingredients, Sports Nutrition Frankenfuels, Illegally Laced Compounds & More.," and he's been studying up on plenty more since that show, so prepare for a wild ride on today's podcast. Shawn, who is an MPH, LDN, RD, CISSN, FISSN, is a leading nutritional biochemist and expert on health optimization. He has formulated over 500 supplements, foods, beverages, and cosmeceuticals, has patented 10 novel ingredients, and is now known as the Ingredientologist—the scientist of ingredients. Formerly a chief clinical dietitian with over a decade of clinical experience, he has counseled thousands of people on natural health solutions such as keto, paleo, fasting, and supplements. He has also personally overcome various health issues including Epstein-Barr virus, chronic fatigue syndrome, fibromyalgia, depression, insomnia, obesity, and a pituitary tumor. As a world-renowned thought leader on mitochondrial health, he has been paid to speak on five different continents. His insights have been prominently featured in documentaries, nationally syndicated radio programs, and regularly on morning television. Shawn's expertise can help any health-conscious individual to better manage stress and experience higher performance and more energy through utilizing his practical research-backed solutions. During this discussion, you'll discover: -What Shawn had for breakfast the day of the interview...7:11 He was 40 hours into a 72-hour fast 36 to 48 hours into the fast is when he starts to feel amazing Pique fasting tea Redmond Real Sea Salt Redmond Re-Lyte Electrolyte Drink Mix Hypernatremia, and why slight dehydration isn't a bad thing for performance...9:40 Hypernatremia: not enough sodium in the blood Athletes are not only more hypernatremic than dehydrated, but usually both Electrolyte formulas are fine, but more salt is lost while sweating Keto dieters tend to be hypernatremic Hunger and headaches may be a sign of hypernatremia rather than a lack of water Redmond Real Salt (contains trace minerals, family-oriented company) Real salt tested low in contamination (no anti-humectant added to dry out the salt) Celtic Sea Salt (recommended by Robert Slovak) Ben's morning hydration regimen: Adds Quinton Hypertonic Minerals to well water from his property Vitamin C 2:1 ratio to baking soda Water and Wellness hydrogen tablets BGF podcasts on deuterium depleted water Deuterium Demystified: Everything You Need To Know About Deuterium Depleted Water (DDW), How To Lower Deuterium & Much More, With Dr. Ann Cooper And Dr. Que Collins. Water & Water Filtration: Everything You Need To Know About Water Filters, Alkaline Water, Structured Water, Hydrogen-Rich Water, Deuterium-Depleted Water & Much More, With Robert Slovak. Why The War On Cancer Has Failed & What You Can Do About It: Mistletoe, NAD, Deuterium Depleted Water, Melatonin, Gerson Therapy & Beyond, With Dr. Thomas Cowan Vape Pens, Hair Growth Serums, Fixing The Pineal Gland & C60 (The Next Great Longevity Molecule), With Ian Mitchell. H2Bev hydrogen water in a can (use code BEN to save 10%) Avoid glyphosate like the plague (Roundup) -Optimizing glutathione levels for optimal mitochondria...21:35 Mitochondrial glutathione is the main line of defense against cell death; prevents impairment of the electron transport chain N-Acetylcysteine (NAC) is one of the best ways to boost glutathione AlmsBio Mitotherapy, with PQQ and COQ10 (use code BENGREENFIELD10 to save 10%) Bioadvantex's PharmaNAC Thorne NAC (what Shawn uses) -The criteria by which Shawn evaluates a supplement brand...25:30 Contract manufacturing is in some ways better than in-house Thorne, Standard Process, Pure Encapsulations invest heavily in quality control BioTrust spent 2 years working on a formula with Shawn The Nitty-Gritty Underground World of Supplement Ingredients, Sports Nutrition Frankenfuels, Illegally Laced Compounds & More, With Shawn Wells. You get what's on the label, and you don't get what's not on the label A little bit more pricey, but you're paying for that quality Beware of vegetable oils or "proprietary blends" Companies use the leaf or stem in their product when they should be using the root Gingko has to be the leaf; ginseng has to be the root -How Shawn discovered two substances and made them into supplement form...35:45 Theacrine and Dynamine™ Worked with Dr. Hector Lopez and Dr. Tim Ziegenfuss Methylliberine (Dynamine™) In the methylxanthine family (of which caffeine is a part) Enhanced energy and focus Pain reduction Stimulated NAD production No habituation effect as you find in caffeine Less adaptation effect Biggest difference is the half-life Infopathy generator (use code BENG10 for 10% off) (Ben's podcast with Anton Federenko will be published on February 27) Hapbee wearable Theacrine and Dynamine™ are full synthetic (GMP and informed-choice tested for sports - tested athletes can use it); natural extraction is cost-prohibitive, but it does occur naturally in tea leaves and cacao Shawn's energy stack: Creatine Dynamine™ Alpha GPC -The exercise augmenter that has been called "exercise in a bottle"...44:15 Advanced Smart Drugs & Nootropics You’ve Never Heard Of, Rare Japanese Seaweed For Sleep Enhancement, The Most Powerful Form Of Vitamin B1 That Exists & Much More! With Lucas Aoun. Ergogenic Health β-aminoisobutyric Acid - L-Baiba is an exercise mimetic (exercise augmenter) Intense exercise breaks down BCAA muscle pool to use those amino acids for fuel for the workout L-Valine ends up converting into L-Baiba Mitoburn (L-Baiba) Positive things associated with exercise are enhanced when L-Baiba levels are increased in plasma Brown adipose tissue is brown because of the amount of iron; it's more mitochondrially dense (only 2% or so in your body); burns fat like nothing else Babies can't shiver until about 6-9 months to create heat thermogenesis; we have brown adipose tissue for that reason It is around your collarbone because that's your core; it's important to keep heat near your core More brown adipose tissue may be a factor in one's metabolism -Grains of paradise...49:55 Grains of paradise is a type of pepper, gingery taste; similar to capsaicin and ginger Enhances metabolism without a stimulant effect 40mg increased thermogenesis and caloric expenditure of around 100 calories a day -Ben's super easy goals for his upcoming 40th birthday...52:15 Humans are the easiest to kill in all of history Goldilocks zone - just the right amount of hormetic stressors Polyphenols are xenohormetics to plants "Strong people are harder to kill than weak people—and more useful in general." Why Strong People Are Harder To Kill (And How To Get Strong), With Keith Norris. Ben's 40th birthday activity: complete in a 40 hour fasted state: 2-3 rounds of Wim Hof breathing leading up to a 4-minute static breath-hold 1 40 kg kettlebell Turkish get-up per side 4-minute dead hang from a bar  400-meter farmer's walk with a kettlebell in each hand (40kg) 4-minute ice bath at 32°F (use code BENFORGE to save $150 off any Forge) -A different form of berberine that is used to control blood glucose levels...56:30 A Rocket Scientist Homeschooler’s Insider Blood Glucose Monitoring Secrets, The Best Way To Use A Continuous Glucose Monitor (CGM), Blood Sugar Biohacking Tips & Much More, with Josh Clemente of Levels Health Dihydroberberine Consuming berberine at the gut level converts it to dihydroberberine; at the plasma level it is converted back to berberine Berberine is a glucose disposal agent Dihydroberberine is Shawn's number 1 recommended anti-aging ingredient 5x more bioavailable than berberine, and lasts around twice as long Doesn't give you GI distress that you get berberine Mitochondrial hormetic -Shawn's new formula for BHB and thoughts on exogenous ketones...1:03:30 HVMN ketone ester Ketone Aid Patent on active isomer RBHB (aka DBHB) Exogenous ketones can carry excess minerals; causes some GI distress All in powder form, very salty in taste -Preferred medium-chain triglycerides (MCTs) to go with ketones...1:07:00 Caprylic acid (C8) is best for increasing ketones Lauric acid is great as a virucidal and anti-bacterial; monolaurin for the immune system Dom D'Agostino has a patent pending (ketone + C8) Which Ketone Supplement Works Best: Ketone Salts vs. Ketone Esters With Dr. Dominic D’Agostino. -The best way to raise NAD levels...1:09:20 NMN (use code GREENFIELD10 to save 10%) is better than NR Ben Greenfield Interviews Dr. David Sinclair About Lifespan: Why We Age―and Why We Don’t Have To. Intranasal supplements (use code BEN to save 5%) are often administered incorrectly Getting a quality NMN and the correct amount Fisetin, NMN, apigenin the ultimate stack Add in COQ10 and PQQ for the ultimate mitochondrial stack Article by John Lieurance: Mito Fast: A Brand New Advanced Anti-Aging Protocol To Nurture Your Mitochondria, Boost Autophagy, & Rejuvenate Your Stem Cells.  Iontophoresis NAD patches -And much more! Resources from this episode: - Shawn Wells: The ENERGY Formula: Six Life Changing Ingredients to Unleash Your Limitless Potential The Nitty-Gritty Underground World of Supplement Ingredients, Sports Nutrition Frankenfuels, Illegally Laced Compounds & More. - Podcasts and article: Deuterium Demystified: Everything You Need To Know About Deuterium Depleted Water (DDW), How To Lower Deuterium & Much More, With Dr. Ann Cooper And Dr. Que Collins. Water & Water Filtration: Everything You Need To Know About Water Filters, Alkaline Water, Structured Water, Hydrogen-Rich Water, Deuterium-Depleted Water & Much More, With Robert Slovak. Why The War On Cancer Has Failed & What You Can Do About It: Mistletoe, NAD, Deuterium Depleted Water, Melatonin, Gerson Therapy & Beyond, With Dr. Thomas Cowan Vape Pens, Hair Growth Serums, Fixing The Pineal Gland & C60 (The Next Great Longevity Molecule), With Ian Mitchell. Advanced Smart Drugs & Nootropics You’ve Never Heard Of, Rare Japanese Seaweed For Sleep Enhancement, The Most Powerful Form Of Vitamin B1 That Exists & Much More! With Lucas Aoun. A Rocket Scientist Homeschooler’s Insider Blood Glucose Monitoring Secrets, The Best Way To Use A Continuous Glucose Monitor (CGM), Blood Sugar Biohacking Tips & Much More, with Josh Clemente Which Ketone Supplement Works Best: Ketone Salts vs. Ketone Esters With Dr. Dominic D’Agostino. Ben Greenfield Interviews Dr. David Sinclair About Lifespan: Why We Age―and Why We Don’t Have To. Why Strong People Are Harder To Kill (And How To Get Strong), With Keith Norris.Mito Fast: A Brand New Advanced Anti-Aging Protocol To Nurture Your Mitochondria, Boost Autophagy, & Rejuvenate Your Stem Cells. - Food and supplements: Pique Tea Redmond Real Sea Salt Redmond Re-Lyte Celtic Sea Salt Quinton Hypertonic Vitamin C Baking Soda Water and Wellness Hydrogen Tablets H2Bev (use code BEN to save 10%) NAC AlmsBio Mitotherapy (use code BENGREENFIELD10 to save 10%) Bioadvantex's PharmaNAC Theacrine Dynamine™ Infopathy (use code BENG10 for 10% off) Creatine Alpha GPC L-Valine Mitoburn (L-Baiba) Grains of Paradise Dihydroberberine Berberine HVMN Ketone Aid Caprylic Acid (C8) Monolaurin NMN (use code GREENFIELD10 to save 10%) Nicotinamide Riboside NeuroNAD Intranasal Spray (use code BEN to save 5%) Fisetin Apigenin COQ10 PQQ NAD Patches - Other resources: Hapbee Wearable Kettlebell Morozko Forge (use code BENFORGE to save $150) Wim Hof Breathing Methylxanthine Turkish Get-up Video Dead Hang Video Farmer's Walk with a Kettlebell Video Episode sponsors: -Kion Coffee: Carefully selected and roasted for taste, purity, high antioxidants, and health. BGF listeners save 20% off your first order with code BGF20. -Chili Technologies: ChiliSleep makes both the chiliPAD and OOLER, innovative options that fit over the top of your mattress and use water to control the temperature of your bed and help lower your core body temperature to trigger deep, relaxing sleep. -Paleovalley Beef Sticks: 100% grass-fed AND grass-finished. Keto friendly and higher levels of Omega 3 Fatty Acids. Receive a 15% discount on your order when you use my link. -Butcher Box: Delivers healthy 100% grass-fed and finished beef, free-range organic chicken, and heritage breed pork directly to your door on a monthly basis. All their products are humanely raised and NEVER given antibiotics or hormones.  -Spiritual Disciplines Journal: The new Spiritual Disciplines Journal by Ben Greenfield is coming soon! Sign up to download a free preview and get notified once it's ready. Do you have questions, thoughts, or feedback for Shawn or me? Leave your comments below and one of us will reply!

Could your genetics determine which keto plan will work best for you? We talk all about this in Episode 1704 of JIMMY RANTS on the LLVLC Show. “Just telling people to go keto is not enough. We need to know what kind of keto is going to work for that person.” -Jimmy Moore On today’s episode of JIMMY RANTS on The LLVLC Show, I share a newly published paper in the journal BMJ Nutrition, Prevention & Health by Dr. Lucia Aronica, Dr. Jeff Volek, Dr. Angela Poff (@angelapoff), and Dr. Dominic D’Agostino (@dominic.dagostino.kt) entitled “Genetic variants for personalised management of very low carbohydrate ketogenic diets” (LINK TO STUDY: Genetic variants for personalised management of very low carbohydrate ketogenic diets | BMJ Nutrition, Prevention & Health​). They put out the call for clinicians and researchers to look more closely at individual patient genetics to determine the effectiveness of using a ketogenic diet therapy. With all the genetic testing at our disposal nowadays, this seems like a logical next step in creating an environment for people to be successful in their weight and health goals. This is hot off the presses and so important! ENJOY!

Today’s episode is proudly sponsored by Paleovalley and its Essential C Complex. Not only does this immunity-boosting product have the three most potent sources of Vitamin C on the planet, but it also gives you 750% of the daily recommended dose -- exactly the amount your immune system needs to stay in top shape. Hurry and grab yours from Paleovalley.com and be sure to use code JOCKERS at checkout for an extra 15% off!   BIG NEWS! Dr. Jockers just released his BRAND NEW book on Fasting! It’s called — Fasting Transformation: A Functional Guide To Burn Fat, Heal Your Body And Transform Your Life With Intermittent And Extended Fasting. AND… we’re so excited that it’s now available on AMAZON! We’d love your support (and if you like the book) I know he’d appreciate a review too! Claim Your Copy Here    The ketogenic diet has become a massive practice, all thanks to its evidence-based effects on weight loss. If you want to transition into a state of ketosis, Dr. Dominic D’agostino shares how fasting can help speed up the process. Dr. D’agostino is an associate professor and a research scientist with a laboratory that is currently focused on developing and testing metabolic-based strategies for the treatment of seizure, epilepsy, neurodegenerative diseases, and cancer. In this episode, he discusses the relevance of nutritional ketosis and fasting that goes beyond weight loss. He reveals science-based facts on how fasting and ketosis are playing major roles in combating these neurodegenerative diseases and aiding in the treatment of cancer patients.   “It’s important to maintain a ketosis state because it’s really turning down many of the drivers of cancer growth.” -Dr. Dominic D'agostino   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   In This Episode:   - Newsflash! Ketosis has a superpower to alter your genetic makeup, affecting how your body adapts to viruses and other changes around you   - Ketosis also critically impacts the give-and-take between your calming GABA and agitating glutamate for less anxiety   - The jaw-dropping health benefits you can enjoy thanks to a new bank of cellular energy from ketones   - Easy as 1, 2, 3 -- the number of times you should go into a state of nutritional ketosis to most effectively transition from the old to the new you   - How fasting braces you to combat various types of cancer, listed one by one   - The vital steps a cancer patient must take before a fast if you are facing chemotherapy in your future   - A high fat -- yet extremely powerful -- compound that kicks up ketones and lowers blood glucose   Resources:   - Paleovalley.com – use code JOCKERS to get 15% off   - The Fasting Transformation by Dr. David Jockers   Connect with Dr. Dominic D'agostino:   - Website - https://www.ketonutrition.org/   - Facebook - https://www.facebook.com/ketonutrition.org   - Instagram - https://www.instagram.com/dominic.dagostino.kt/   - Twitter - https://twitter.com/DominicDAgosti2   - Youtube - https://www.youtube.com/channel/UCqVNHZUXqn1sFvgppi5Zpmg/videos   Connect with Dr. Jockers:   - Instagram – https://www.instagram.com/drjockers/   - Facebook – https://www.facebook.com/DrDavidJockers   - YouTube – https://www.youtube.com/user/djockers   - Website – https://drjockers.com/   - If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/  

Professor Dominic D'Agostino has developed an approach for metabolically starving cancer cells through a ketogenic diet and breathing techniques. This fascinating conversation focused on getting the balance right of how we fuel our bodies is critical to preventing diseases. It turns out holds great promise for dealing with many conditions. I hope you enjoy this conversation I had with Professor Dominic D'Agostino.   You can also watch this episode at www.DrRonEhrlich.com. ----- TIME TO TAKE CONTROL OF YOUR HEALTH? Join our online health workshops. ----- CONNECT WITH ME You can ask questions via social media using my Instagram or Facebook or YouTube page.

To watch this episode, please visit Rachel’s YouTube channel. Listeners can find Dr. Dominic D’Agostino at his website https://www.ketonutrition.org/, Twitter @DominicDAgosti2, on Facebook @Dominic D’Agostino and on Instagram dominic.dagostino.kt. Dr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida and Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests metabolic-based strategies for neurological disorders, cancer, and for enhancing safety and resilience of military personnel in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. In this episode, we chat all about exogenous ketones, ‘the keto diet vs. the drink,’ fuel supplementation for performance, benefits of a higher protein ketogenic approach, and more! "I have changed my mind pretty significantly through self experimentation. But even from a clinical research realm, you can incorporate a higher protein macronutrient ratio, and still be following a ketogenic diet by definition of having elevated ketones." Dr. Dominic D'Agostino "A lot of people think keto is so restrictive. But if you use it in smart ways and you incorporate it into the different seasons of your life, it can be super beneficial, and you can still kind of get the best of both worlds." Rachel Gregory Top Takeaways: A breakdown of what ketones are and some benefits  How to spot the best exogenous ketones The difference between Ketone Salts vs. Ketone Esters Ketones and carbs for performance The benefits of a higher protein ketogenic diet Today’s Questions: What are the positive effects of ketones as signaling molecules, in simple terms? Is there more research coming out in humans with ketogenic diets and exogenous ketones? What are the best exogenous ketones? What is your opinion on taking exogenous ketones and not following a ketogenic diet vs. following a ketogenic diet and also incorporating exogenous ketones? What's your view on the concept of metabolic flexibility? Are there negatives to taking exogenous ketones? What’s the difference between ketone salts and ketone esters? What’s your personal diet and training protocol like? Show Notes: [0:00] Welcome back to MetFlex and Chill! Rachel gives a brief background about guest Dr. Dominic D’Agostino dominic.dagostino.kt [2:00] If you are enjoying the show please like, tag @rachelgregory.cns and share! Another way to help spread the word is to share a review on itunes!   [2:30] Rachel introduces guest Dr. Dominic D’Agostino to the listeners [3:30] Dr. Agostino gives a brief bio on how he got into nutrition and specifically ketogenic diets [4:30] Oxygen Toxicity Seizures  [8:30] Question: What are the positive effects of ketones as signaling molecules, in simple terms? [11:00] GABA [13:30] Ketones also have epigenetic effects [18:00] Glucose Transporter Deficiency Syndrome (GLUT 1 Deficiency Syndrome) [19:00] Dr. Richard Veech [21:00] Rachel’s CrossFit Study [22:00] Question: Is there more research coming out in humans with ketogenic diets and exogenous ketones? Can you speak to that versus animal research? [23:00] clinicaltrials.gov  [27:00] Question: What are the best exogenous ketones? [28:00] Ketone Supplements [29:00] How to Choose an Exogenous Ketone Supplement [29:30] Question: What is your opinion on taking exogenous ketones and not following a ketogenic diet vs. following a ketogenic diet and also incorporating exogenous ketones? [38:30] Question: What's your view on the concept of metabolic flexibility? [38:30] Episode 21: The Science of Metabolic Flexibility with Dr. Mike T Nelson [45:30] Question: Are there negatives to taking exogenous ketones? [48:30] Question: What’s the difference between ketone salts and ketone esters? [52:30] Question: Dr. Dom’s personal diet and training protocol? [59:00] Question: Anything you’ve changed your mind about in the past year and why? [1:03:00] You can find Dr. Dominic D’Agostino at https://www.ketonutrition.org/ and on Instagram dominic.dagostino.kt [1:03:00] Thanks for listening to another episode! If you are curious about Dr. D’Agostino’s work check it out at https://www.ketonutrition.org/  If you are enjoying the show please like, tag @rachelgregory.cns and share!   --- Join the FREE MetFLex Life Course: www.metflexandchill.com Rachel Gregory (@rachelgregory.cns) is a Board-Certified Nutrition Specialist, Strength and Conditioning Specialist, and Author of the best-selling book, 21-Day Ketogenic Diet Weight Loss Challenge. She received her Master’s Degree in Nutrition & Exercise Physiology from James Madison University and Bachelor’s Degree in Sports Medicine from the University of Miami. Rachel helps her clients transform their lives by starting with the physical (body), realizing the power of the mental (mindset), and ultimately gaining massive confidence that bleeds into every aspect of their lives (family, relationships, work, etc.).

As Todd mentions in the show, here is the link for your penny bottle of Dry Farm Wines: dryfarmwines.com/coachtara Today, after 15 years in the wine business, his life is dedicated to educating and helping people make better choices about food, nutrition, and how they think about consuming alcohol. As the founder of Dry Farm Wines, a writer, speaker, and a leader in the organic/Natural Wine movement, he has widely educated communities on conscious consumption. Todd is deeply passionate about bringing people together to share love and laughter through Natural Wine. Todd is a self described biohacker who practices daily meditation, Wim Hof breathing, cold thermogenesis, a ketogenic diet, and daily 22 hour intermittent fasting. He is also a frequent speaker on topics including ketogenic lifestyle, meditation, and the Dry Farm Wines unique company culture. His entire team gathers each morning for a meditation and gratitude practice. Built on a foundation of honesty and peace, Dry Farm Wines has seen remarkable growth in the last three years, making it one of the fastest-growing private companies in the U.S., without any debt or investors. Dry Farm Wines is endorsed by many leading U.S. health influencers including Mark Sisson, Dave Asprey, Ben Greenfield, Robb Wolf, Wellness Mama, Dr. Dominic D’Agostino, and Chalene Johnson, to name a few. Todd has also been the featured guest on many of these influencers’ podcasts. Dry Farm Wines is the official wine sponsor for many of the leading health and performance conferences worldwide, sharing over 12,000 bottles each year. Such events include Paleof(x), Joe Polish’s Genius Network Conference, LowCarbUSA, Health Optimization Summit, Metabolic Health Summit, and JJ Virgin’s Mindshare Summits. Dry Farm Wines sources pure Natural Wines and lab tests them to ensure each bottle is sugar free (0-0.15g per glass), lower in sulfites, and lower in alcohol (under 12.5% alc/vol). The wines are friendly to low carb, Paleo, ketogenic, and low sugar diets. Dry Farm Wines is dedicated to supporting small natural growers, currently sourcing from 600 family farmers who preserve 87,000 acres of organic vineyards and save 1.4 billion gallons of water annually by not irrigating their vines. They vet each grower’s practice and support those who focus on regenerative farming, biodiversity, hand harvesting, and the absence of industrial additives. Dry Farm Wines is proud to be the largest Natural Wine merchant in the world, bringing awareness to Natural Wine consumption and supporting farmers who honor the soil. Learn more and snag your penny bottle through this link: dryfarmwines.com/coachtara Upgraded Formulas - Inside Out Health Podcast Special Offers: Click HERE for the Upgraded Formulas Hair Test Kit Special Offer Click HERE for the Upgraded Formulas Main Site & Get 10% OFF Everything with Coupon Code: COACHTARA Ready to enhance your metabolism? Learn about my Keto In & Out system HERE. Want one on one coaching? Learn more about it HERE.

Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. This episode is hosted by Dr. Shawn Baker MD. Find him at https://shawn-baker.com

: Episode 1718 - On this Sunday Show, we replay a best-of Friday show from 2016. Dominic D'Agostino rejoins Vinnie Tortorich to discuss ketogenic diets, the relationship between keto and weight loss, and more.  Https://www.vinnietortorich.com/2020/11/best-of-keto-weight-loss-dr-dominic-dagostino-episode-1718 PLEASE SUPPORT OUR SPONSORS DR. DOMINIC D'AGOSTINO Dominic has been coming on the show since the very start. He is the associate professor at USF, college of medicine. He's in the department of molecular pharmacology and physiology. Dr. D'Agostino is also senior research scientist at Institute for Human and Machine Cognition. He has his PhD, of course . Susan Masino is a colleague of his. http://www.ketonutrition.org/ He is a big proponent of the ketogenic diet. https://www.amazon.com/gp/product/0190497998/ref=as_li_qf_sp_asin_il_tl?ie=UTF8&tag=vinnitorto-20&camp=1789&creative=9325&linkCode=as2&creativeASIN=0190497998&linkId=61491ce009dc9a9f321b0f2edde8f556 KETOSIS AND SEIZURE CONTROL Dr. D'Agostino started doing research for ketogenic diet in 2010. He did substantial research into deep diving seizures and a ketogenic diet. KETO AND WEIGHT LOSS There was a study that came out that said ketogenic diet was not conducive to weight loss. This contradicts much of what we know! From the medical community that implements this diet for medical purposes, even they agree that this diet is helpful for weight loss. Weight loss is a "side effect" of ketosis. Ketosis dampens your appetite. When you are eating ketogenic diet, you will feel more sated from less. You also stop eating less processed crap which is the stuff that makes you hungrier. Exogenous ketones: these are the ketones that you can consume in powder. This can help get into ketosis without actually consuming that much of fat. It's better just to be in real ketosis, consuming lots of fat.. Exogenous ketones can help some, but others it has no effect. Dr. D'Agostino did this experiment with rodents. They were eating carb diets, and a good amount did not lose weight even with exogenous ketones. Some were able to lose 15% body fat, but this was only in a few. They are looking into why that is the case. FAT DOC IS OUT Go watch it now! We need people to buy and review for it to stay at the top of iTunes pages. Please also share it with family and friends! Available for both rental and purchase. You can also buy hardcopy or watch online at Amazon. YOU CAN NOW STREAM FOR FREE ON AMAZON PRIME IF YOU HAVE IT! Fat Doc 2 is in the works! Keep an eye out. RESOURCES Https://www.vinnietortorich.com Https://www.purevitaminclub.com Https://www.purevitaminclub.co.uk Https://www.purecoffeeclub.com https://www.villacappelli.com Https://www.nsngfoods.com Https://www.crowdcow.com/vinnie Https://www.bit.ly/fatdocumentary  

Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation.  This episode is hosted by MeatRx coach Amber. Find her at https://meatrx.com/product/amber-w/  

Dr. D'Agostino is an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. Episode Sponsor: BiOptimizers – www.bioptimizers.com/human promo code: HUMAN10 Swanson - www.swanson.com promo code: HUMAN20 Support the show: - https://www.patreon.com/HPOpodcast or https://www.paypal.me/hpopod Website: https://zachbitter.com, https://www.ketonutrition.org/ Instagram handles: @zachbitter, @dominic.dagostino.kt  Twitter handles: @zbitter, @DominicDAgosti2  Facebook handles: @zach.bitter, @ketonutrition.org  YouTube: Zach (https://www.youtube.com/c/ZachBitterUltra) Dom (https://www.youtube.com/channel/UCqVNHZUXqn1sFvgppi5Zpmg/videos ) Consultation with Zach: https://calendly.com/zbittercoaching  If you would like to contact the show, please send your emails to hpopodcast@gmail.com

Dr. Dominic D'Agostino is an assistant professor at the University of South Florida in Tampa and all-around expert on ketosis. Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. Connect with Dominic D'Agostino: https://www.ketonutrition.org/ @DominicDAgosti2 on Twitter https://www.facebook.com/dominic.dagostino.1 @dominic.dagostino.kt on Instagram Connect with Nick Holderbaum: Personal Health Coaching: https://www.primalosophy.com/ https://www.primalosophy.com/unfuckedfirefighter Nick Holderbaum's Weekly Newsletter: Sunday Goods (T): @primalosophy (IG): @primalosophy Apple: https://podcasts.apple.com/us/podcast/the-primalosophy-podcast/id1462578947 Spotify YouTube: https://www.youtube.com/channel/UCBn7jiHxx2jzXydzDqrJT2A The Unfucked Firefighter Challenge

What is the latest keto research telling us? Here to break it down and disseminate it for us is Dominic D'Agostino. You might remember him from episode 35: Dominic is actually Dr. Dominic, a professor in the Dept. of Molecular Pharmacology and Physiology at University of South Florida.   He's also a research scientist at the Institute for Human and Machine Cognition. His lab works to develop and test metabolic-based approaches for neurological disorders, cancers, etc.

Josiah sits down with Dr. Dominic D'Agostino to discuss the Keto Diet and how going "low carb" may have significant health impacts. Dr. Agostino is one the world's leading experts and researchers around understanding the anticonvulsant and neuroprotective mechanism of the keto diet and ketone metabolite supplementation. Here's the link to CGM kit to get you in front of the line. levels.link/dom Connect with Dom: https://www.ketonutrition.org/https://ketonetechnologies.com/Download our Look Good Naked Guide: LookGoodNaked.org

Dr. Dominic D'Agostino returns to the show to talk about the new breakthroughs in the world of ketogenic research. What are the benefits of Ketones supplementation? Who are some of the best doctors for ketogenic treatment? How important is sleep for a healthy lifestyle? Is there a way to block EMFs from affecting our bodies? "Nixon declared the war on cancer in the sixties and yet we still have a high body count. What happened?" David asks. Dr. D'Agostino points out the importance of nutritional prescription which, unfortunately, has been largely ignored in the medical industry. Will the standard of care and treatment of diseases like cancer and diabetes change to something less toxic? Listen to the full episode to find out and more. Visit Dr. Dominic D'Agostino's website ketonutrition.org Email A Neighbor's Choice with a guest suggestion, story tip or question at hello@aneighborschoice.com Visit the A Neighbor's Choice website at aneighborschoice.com

Have you ever thought how you got into the expertise or profession you are in right now and what led you to pursue that dream?   We had an interesting interview with the Worlds #1 Ketogenic Expert, Dominic D’ Agostino. We talked about his lifestyle, entrepreneurial journey, and how much impact his work and research have on people’s day to day lives.   Dom shares with us what keeps him busy these days and some helpful information about the research he is doing and some cutting-edge tips about ketogenic diets, ketosis, supplements, and other amazing stuff.   IN THIS EPISODE, YOU WILL LEARN: Why the ketogenic diet is more suitable for weight loss and how to pay attention on this specific diet and practice it correctly A behind the scenes look into Dominic’s lifestyle and some of the awesome entrepreneurial projects he’s working on The latest results and research behind the ketogenic diet Is the ketogenic diet beneficial and how to best utilize it in your diet and lifestyle?   If you are a fitness enthusiast or fitness professional looking for the latest cutting-edge tips within the ketogenic diet, then Tune in to this episode and Let me know what you think of it.   Follow us on Instagram https://www.instagram.com/chrisandericmartinez/ and see the full Show Notes to this episode here https://www.liveadynamiclifestyle.com/podcast/the-never-before-seen-lifestyle-and-entrepreneurial-journey-with-the-worlds-1-ketogenic-diet-expert-dominic-dagostino/   Make sure to follow Dominic on his Instagram here https://www.instagram.com/dominic.dagostino.kt/   And make sure to join his Free Community Newsletter here https://www.ketonutrition.org/   PS: ARE YOU READY TO RISE AS A FIT PRO?   Are You Looking to Add Online Training to Your In-Person Training Business!   If You Want to Learn the Secrets to Create More Income, Influence, Impact, And Independence…   Then Get Grab Our New Book “Rise Of The Fit Pros” and Grab Your Free Gifts Here https://www.riseofthefitpros.com/book1591229422414

Welcome to the Body Mind Empowerment podcast I’m your host Siim Land and our guest today is Dr Dominic D’Agostino. Dr Dom has a PhD in neuroscience and physiology. He’s a professor at the University of South Florida and is considered one of the world’s top experts in ketosis, ketogenic diets, fasting, and hyperbaric oxygen therapy. Timestamps: How Dom Got Into Ketosis 01:45 Effects of Ketosis on Epilepsy 06:50 Why Do Ketones Benefit the Brain 11:30 Benefits of Stable Blood Sugar 17:16 Ketoacidosis and High Ketones 25:15 Can Ketosis Increase Oxygen Efficiency 28:40 CO2 Production and Mitochondrial Function 33:50 How to Achieve Metabolic Flexibility 41:07 Does Keto Speed Up the Metabolism 44:00 Difference Between Ketone Esters and Keto Salts 47:30  And much more Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body.  With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That’s an AMAZING value. And I promise that deal is ONLY available on this specific website.   www.magbreakthrough.com/siim   Click Here to Support the Show on Patreon!    Show Notes Dr Dom D'Agostino Instagram Ketonutrition.org Get Magnesium Breakthrough 10% OFF Use Code SIIM for a 10% Discount on the KAATSU Bands Get Your Biomarkers Tested with Lets Get Checked At-Home Tests! Use Code SIIMLAND for a 20% Discount! My NEW Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim

Dr. Dominic D’Agostino is a leading researcher into the therapeutic effects of the ketogenic diet. He is featured on Joe Rogan, Tim Ferriss, Impact Theory, TED, and dozens of other top media outlets. This is a wide-spanning conversation on high fat diets, time-restricted feeding, fasting, and even nutrition psychotherapy.Who is Dr. Dominic D’Agostino? Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer. To investigate the mechanism of these pathologies he uses a variety of in vivo and in vitro techniques, including radio-telemetry (EEG, EMG), electrophysiology, fluorescence microscopy, confocal microscopy, atomic force microscopy (AFM), biochemical assays and in vivo bioluminescence imaging. His laboratory has adapted many of these techniques for use inside environmental chambers, which allows them to manipulate oxygen concentrations (from hypoxia to hyperbaric oxygen). His current project is to identify cellular mechanisms of seizures from CNS oxygen toxicity and to develop mitigation strategies against it. His efforts have focused specifically on measuring brain EEG, neuronal excitability, reactive oxygen species (ROS) production and biomarkers of oxidative stress. The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. The shift in brain metabolism (from glucose to ketones) reduces neuronal hyperexcitability, oxidative stress and enhances brain energy metabolism. This approach can be used to treat a wide variety of pathologies linked pathophysiologically to metabolic dysregulation, including cancer. Other areas of interest include researching drugs that target cancer-specific metabolic pathways. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.With a wide range of research interests, Dominic D’Agostino holds membership in the Undersea and Hyperbaric Medicine Society, Aerospace Medical Association, Society of Neuroscience, American Physiological Society, and the American Association of Cancer Research, additionally serving on numerous editorial boards and as a Reviewer for dozens scholarly publications. Before joining the faculty at USF, D’Agostino completed a postdoctoral fellowship in neuroscience at Boonshoft School of Medicine at Wright State University. A graduate of Robert Wood Johnson Medical School and Rutgers University, Dominic D’Agostino earned his Ph.D. and B.S. from these respective institutions.Highlights[3:44] Making two different diets work at home[7:14] Life underwater for 10 days[20:01] APOE4 and the Ketogenic diet's effects on Alzheimer's disease [27:37] Effects of removing dairy and saturated fat on biomarkers[33:21] The ketogenic diet and atherosclerosis[37:40] How to build muscle in ketosis[41:27] Taking a year off from weightlifting[47:40] How to lose the benefits of intermittent fasting[54:10] Dr. Dom’s opinion on one meal a day[56:16] Should you schedule cheat meals?[1:06:00] The importance of micronutrients[1:08:05] The best keto snacks[1:13:40] Adherence and ketosisResourcesNASA NEEMONEEMO 22 Photo GalleryThe Charlie FoundationByrd Alzheimer's InstituteMary NewportDr. Dom’s BlogPractical Guides to the Keto DietSponsorsKeto Nutritionketonutrition.org is Dr. Dominic D’Agostino’s personal website. If you go there and purchase any of the products available, you will be donating to Dr. Dom’s research. 100% of profits go to Dr. D'Agostino's time. Please head on over to ketonutrition.org/support and discover the ways that you can help Dr. Dominic and his team achieve their goals.BiOptimizersMost supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. That’s why I’m so excited to tell you about a new magnesium product I’ve been taking now called, Magnesium Breakthrough. It’s the ULTIMATE magnesium supplement, easily the best I’ve ever seen or experienced... with all 7 forms of this mineral.I’m even more excited because it’s finally BACK IN STOCK! Magnesium Breakthrough has been selling faster than the company who makes it, BiOptimizers, has been able to keep up with. It’s already sold out a few times and due to supply shortages with everything going on in the world, it could very well be sold out again shortly.I was able to arrange for some stock to be set aside just for our audience and I guarantee it’s the BEST deal available on this product. Seriously! With volume discounts combined with our custom 10% coupon code, BOOMER, you can save up to 40% off select packages of Magnesium Breakthrough! That’s an AMAZING value. And I promise that deal is ONLY available on this specific website, www.magbreakthrough.com/boomerMagnesium Breakthrough is the most effective magnesium supplement I’ve ever tried. Say goodbye to having to buy 7 different bottles of magnesiums to get the complete dose.Go to www.magbreakthrough.com/boomer and use coupon code BOOMER to save up to 40% off select packages to get the most full-spectrum and effective magnesium product ever.Continue Your High Performance Journey with Dr. Dom D’AgostinoWebsiteInstagramFacebookTwitterYouTubeDisclaimer This information is being provided to you for educational and informational purposes only. This is being provided as a self-help tool to help you understand your genetics, biodata and other information to enhance your performance. It is not medical or psychological advice. Virtuosity LLC, or Decoding Superhuman, is not a doctor. Virtuosity LLC is not treating, preventing, healing, or diagnosing disease. This information is to be used at your own risk based on your own judgment. For the full Disclaimer, please go to (Decodingsuperhuman.com/disclaimer). See acast.com/privacy for privacy and opt-out information.

Dominic D'Agostino PhD of University of South Florida joins the show to discuss the overwhelming benefits of ketogenic diet and also how his laboratory tests and develops metabolic therapies for treating a variety of sicknesses including epilepsy, neurodegenerative diseases, and cancer. All this and more on A Neighbor's Choice! Original airdate: April 23, 2020 Reach Dominic D'Agostino at Ketonutrition.org Email A Neighbor's Choice with a guest suggestion, story tip or question at hello@aneighborschoice.com Find David Gornoski on YouTube Visit the A Neighbor's Choice website at www.aneighborschoice.com

The keto diet has been sweeping the health world for quite a while now, but I still get so many questions about whether this high fat, low carb diet approach is really healthy for women. Lucky for us, I’m here now with one of the top experts in the world on the topic, whose research …

Dr. Dominic D’Agostino is the “King of Keto”. As the world’s leading expert on the Ketogenic diet, nutritional and supplemental ketosis, Dr. D'Agostino has worked with the United States military and NASA to help enhance the performance of war fighters and astronauts, is a professor at the University of South Florida and the Morsani College of Medicine, as well as a certified aquanaut. On top of that, he deadlifted 500lbs after fasting for 7-days straight. Subscribe to the Podcast on on Platforms! ➢ https://lnk.to/PowerProjectPodcast Visit our sponsors: ➢Icon Meals: http://iconmeals.com/ Use Code "POWERPROJECT" for 10% off ➢Piedmontese Beef: https://www.piedmontese.com/ Use Code "POWERPROJECT" at checkout for 25% off your order plus FREE 2-Day Shipping on orders of $99 ➢Perfect Keto: http://perfectketo.com/powerproject Use Code "POWERPROJECT10" at checkout for $10 off $40 or more! ➢SHOP NOW: https://markbellslingshot.com/ Enter Discount code, "POWERPROJECT" at checkout and receive 15% off all Sling Shots Follow Mark Bell's Power Project Podcast ➢ Insta: https://www.instagram.com/markbellspowerproject ➢ https://www.facebook.com/markbellspowerproject ➢ Twitter: https://twitter.com/mbpowerproject ➢ LinkedIn:https://www.linkedin.com/in/powerproject/ ➢ YouTube: https://www.youtube.com/markbellspowerproject ➢TikTok: http://bit.ly/pptiktok FOLLOW Mark Bell ➢ Instagram: https://www.instagram.com/marksmellybell ➢ Facebook: https://www.facebook.com/MarkBellSuperTraining ➢ Twitter: https://twitter.com/marksmellybell ➢ Snapchat: marksmellybell ➢Mark Bell's Daily Workouts, Nutrition and More: https://www.markbell.com/ Follow Nsima Inyang ➢ Instagram: https://www.instagram.com/nsimainyang/ Podcast Produced by Andrew Zaragoza ➢ Instagram: https://www.instagram.com/iamandrewz #PowerProject #Podcast #MarkBell

Discussing KETO Nutrition, Farm Life, Toxicity, Fasting, Ketones, and more:Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC).  His laboratory develops and tests nutritional strategies and metabolic-based therapies for neurological disorders, seizures, cancer, and metabolic wellness. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance the safety and physiological resilience of military personnel in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and nonprofit foundations.   Quote: Of all the paths you take in life, make sure a few of them are dirt. - John Muir   Top 3 Hot Point Takeaways:Seizures, Epilepsy, Diabetes, and Anti-Inflammatory Benefits Keto, Ketogenic Diet, Ketosis, and Ketones KETO Nutrition, Nutritional Ketosis, and Nutritional Fasting   Today’s Resource Links from the Podcast: ketonutrition.org (http://ketonutrition.org) Facebook:  https://www.facebook.com/dominic.dagostino.1 (https://www.facebook.com/dominic.dagostino.1) Twitter:  https://twitter.com/DominicDAgosti2 (https://twitter.com/DominicDAgosti2) Instagram:  https://www.instagram.com/dominic.dagostino.kt/ (https://www.instagram.com/dominic.dagostino.kt/) LinkedIn:  https://www.linkedin.com/in/dominic-d-agostino-156014b/ (https://www.linkedin.com/in/dominic-d-agostino-156014b/)   Our Mentioned Influencers:Charlie Foundation from charliefoundation.org (http://charliefoundation.org) FAT: a documentary from VinnieTortorich.com (http://VinnieTortorich.com) Metabolic Health Summit via metabolichealthsummit.com (http://metabolichealthsummit.com) Type-1 Diabetics TEDx Talk by Andrew Koutnik via https://youtu.be/eDfgulV_F6o (https://youtu.be/eDfgulV_F6o)   Timestamped Show Notes:00:30: Introduction 10:00: I grew up studying nutrition, I never heard of anything in fasting ketogenic diets. They were the things to avoid at all costs, right? So, I went to Rutgers University actually grew up in Allentown, New Jersey. 20:00: It's really a result of many things going on, but it's giving the brain an alternative fuel that allows the brain to function under these extreme environments. It also changes some of the neuropharmacologies of the brain in ways that we're just understanding now. 30:00: My wife is Hungarian and she and I went over there. They're eating brains, kidneys, and liver. I mean this is what they have every night. So it's a little strange and it was about the same time I met my wife and actually started doing ketogenic research about the same time. So now she has gotten to incorporate a lot more organ meat into our diets. We grew up hunting, the liver was what we would give to the dogs. We would never think about eating the deer liver, we would just dress the deer when we got home and just keep the neat stuff. 40:00: Kristi Storoschuk helps on so many projects, she's been like a godsend as our Head Writer. My student Andrew Koutnik is now Dr. Koutnik. He's type one diabetic and also does nutritional ketosis and gave a TEDx talk on nutritional ketosis. You can look them up, fantastic TEDx talks and is a new writer who's super educated and passionate about this. 51:00: I would tell people to check out the Metabolic Health Summit. I have a link to that on ketonutrition.org 54:00: Final Words   Our Final Words of the Show:I'm a scientist, I'm a data-driven person, and I do experiments in the lab. But the thing that I think is really the...

Learn  how we can nourish ourselves while starving cancer cells and how there  is a right diet for most diseases. In this interview, Dr. D’Agostino  explains how diet plays a huge role and the Ketonutrition.org is the go  to resource if you are interested in one specific disease and the right  diet for it . Direct all questions and comments to:  drspodcastshow@gmail.com

  Keto diets have been extremely popular lately, but how does being in ketosis impact our training and performance? The expert on these topics is Dr. Dominic D’Agostino. Dr. Dominic is a Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida, and Research Scientist at the Institute for Human and Machine Cognition (IHMC). He is well-respected in the science world as well as the performance industry having been featured on Tim Ferriss' podcast as well as having his research supported by the Department of Defense, the Navy SEALs, etc. 35. Keto Diets, Training and Performance with Dr. Dominic D’Agostino In today's episode, we dig into Dr. D'Agostino's research plus his own personal experience and experimentation with keto diets and bodybuilding, including how he achieved his personal best deadlift while fasting! We also discuss what it means to be "fat adapted" and why our bodies can run on both ketones and glucose at the same time. Dr. D’Agostino says the idea is to adapt our bodies over time by training while we're fasting periodically; if we are training in a state of nutritional ketosis and occasionally consuming carbohydrates then our body recognizes carbs and as ketones both as fuel sources. One strategy to do this could be to eat a carbohydrate-based diet that is low enough to maintain optimal insulin sensitivity while including ketogenic nutrition, such as MCT oils or ketone supplements. But it's important to also do this without necessarily restricting carbohydrates to the point of entering ketosis. And we finish up with a chat about when it's beneficial to be on a keto diet as well as how often to follow a ketogenic protocol to get the full benefit. Dr. D'Agostino suggests we can achieve many of the metabolic benefits and anti-cancer benefits by going keto for just three to five days per month either through fasting or by going down to 500 calories per day. You’ll hear him explain the science behind these approaches plus much more on this fascinating and enriching conversation on today’s edition of the Awesome Health Podcast! Resources for this Episode Dr. Dominic's Website Dr. Dominic on Instagram Dr. Dominic on Facebook Read the Episode Transcript : Wade Lightheart: Good afternoon, good morning and good evening. It's Wade T Lightheart here today with co-founder Matt Gallant. And a super special guest, Dr Dominic D'Agostino. I have been, you know, hoping for this interview for a long time. For those who don't know who Dominic D'Agostino is, he is one of the preeminent experts on ketogenic diets and ketosis. He works with the Navy seals and in a variety of projects that he's done, they're heavily research oriented and the benefits that this potential dietary practice can have both in performance applications as well as physical health issues, you know, related to cancer, things like that. Cognitive function, a bunch of different things. Dom is a professor at the department of molecular pharmacology and physiology at the university of South Florida and a research scientist at the Institute for human and machine cognition. His laboratory develops and tests metabolically based strategies for neurological disorders, cancer and for enhancing the safety and resilience of military personnel in extreme environments. His research is supported by the office of Naval research, department of defense, private organizations and foundations. He just recently came back from a trip from Australia where he was speaking literally in what, five cities in 11 days. And he was gracious enough to take the time to join us on the Awesome Health Podcast. So delighted to have you here. Dom, welcome to the show. Dominic D'Agostino: Great to be here. Thanks for having me Matt and Wade. Matt Gallant: As much as Wade is excited, I'm, I'm even more excited. You know, I've been a fan of your work since. I think I first heard you probably I think on the Tim Ferriss podcast which, which was very enlightening and I've been a longtime keto user and dieter for over 26 years on and off nonstop now for four and a half. And a BiOptimizers, you know, we have these, this three sided triangle of, you know, aesthetics, how we look, the performance and the health side. And I think you're one of the top guys in the world to talk about the performance side and the health side of keto. Cause most people talk more about the aesthetics, the fat loss and that, that component. But today I really like to dive into maybe we could start with some of your background and what you've been doing research wise and then we can get really into all of their current stuff you're doing in a run performance and help. So maybe give us a little bit of background as far as what you've been up to the last five, 10 years. First Quito and kettle research. Dominic D'Agostino: Yeah. for 10 years, well, this quickly, going back to 25 years ago, I was always interested in nutrition and I majored actually in as an undergrad in nutrition scientists and dietetics. And as I navigated my, you know, college career, I realized that there wasn't a whole lot of jobs in nutrition. So I kind of moved to majoring in biology too. And then I did my PhD actually in neuroscience and, and when I finished my pHD I was funded by the office of Navy research for my fellowship, a postdoctoral fellowship. And that was really to understand oxygen toxicity seizures as it pertains to the Navy seal dieter that's using a closed circuit rebreather that they use or operational conditions. There's a stealth component to this equipment. There's no bubbles when you dive underwater. A disadvantage would be that you're breathing high oxygen 100%, actually with a certain type of breather and it just did the be the seawater. Dominic D'Agostino: You can have a seizure and within 10 minutes some people you know can have that and there's really no way to predict or prevent them. So the first area of my research was developing different technologies that would allow us to understand sort of how the brain is working under these conditions. And if you understand the problem, then you can come up with a solution. But we didn't fundamentally understand the problem. So we developed things like microscopes and electrophysiology equipment and telemetry equipment and we adapted that for use inside a hyperbaric chamber. And then over, you know, five or six years, I started to realize that targeting brain energy metabolism and the neuropharmacology of the brain are two strategies to protect the brain under these extreme conditions. And I was sort of interested in antioxidants, loading up animals with antioxidants really did not seem to work much, although in theory it should have. Dominic D’Agostino: But then I started moving towards like coaxing our own bodies to be more resilient. And there was some studies that we've done with fasting rats for 24 to 36 hours and that actually had a remarkable effect at preventing the seizures and it was actually greater neuroprotection than the antiseizure drugs. So I began sort of became interested in how fast and could mitigate and be a mitigation strategy or counter measure against these types of seizures. And then discovered the ketogenic diet, which I thought of, sort of thought I knew, but I really didn't know the whole history of the ketogenic diet, you know, growing up you hear about low carb diets, Atkins diets and you know, I had interested in the ozone diet at one point and a little carb a little bit and I did it kind of on and off for different years. Dominic D’Agostino: But when I delved into the history of the ketogenic diet and met with the practitioners at major universities, like especially Johns Hopkins group I realized that this could potentially be, I could incorporate nutrition back into my research program and do sort of like a nutritional neuroscience project. I would just have to convince my program officer at the department of defense or Navy that, you know, this was a good strategy and the science was actually there like on PubMed, you know, I mean it was good peer reviewed studies sharing that independent of the etiology independent of the cause of the seizures. The ketogenic diet seemed to help across the board. So, and oxygen toxicity seizures are powerful. Tonic clonic seizures we think are being generated in the hippocampus, which was an area that I was studying and published on. And also maybe influencing the neuro control of autonomic regulation and actually did my PhD on respiratory neurobiology brain set. Dominic D’Agostino: So I had a sort of an understanding of, of sort of what was happening and, and a new understanding and appreciation for nutrition as a metabolic therapy. And and I was never taught anything about the ketogenic diet through my four years of training and two, two semesters actually, the advanced nutrition and graduate nutrition. I never even heard about the ketogenic diet being used, and it was like the standard of care for drug refractory epilepsy. So long story short the dietary approach wasn't, it didn't really grab the attention of the program officers. They wanted to see a ketogenic diet sort of in a drug. So I went down the path personally from a research perspective of just studying ketones and different formulations or ketones. But I also started doing the ketogenic diet myself to understand it from the implementation perspective. And, and, and not people weren't doing the ketogenic diet, the clinical ketogenic diet back when I started and maybe 2008, seven or eight. Dominic D’Agostino: But as I followed it, I realized after I got through the initial adaptation, I felt really good. And I I, prior to this, my, my meal frequency was five or six meals a day and I transitioned actually to eating less often and to the point where I adapted to doing intermittent fasting occasionally, once in awhile. And, and then as we developed ketone various ketone technologies, including ketone esters and ketone electrolyte preparations mixed with a MCT and started studying it, we realized that these are very powerful neuroprotective compounds that have a wide range of applications, not just oxygen toxicity seizures, but different metabolic disorders are highly responsive to nutritional ketosis. Some are the standard of care are the ketogenic diet, I should say, is the standard of care for things like metabolic disorders, like glucose transporter deficiency, other deficiency complex. We studied Kabuki syndrome, which is a genetic disease. Dominic D’Agostino: And we look at the role of ketone bodies as an epigenetic regulator activating some genes and silencing others that can impart their therapeutic effects. So, and then cancer too is another area. I've had three PhD students graduate under me training under me that actually focused on looking at the ketogenic diet to impact the growth and proliferation of cancer, metastatic cancer. We we're looking at cancer parts, which is muscle wasting associated with cancer. We're also looking at drugs like Metformin and other metabolic drugs that sort of target different pathways that overlap with the ketogenic diet. So, so I started studying it for something that was relatively esoteric to most people. Oxygen toxicity seizures are now, we now are studying, I would say probably close to a dozen different things including glucose regulation, you know, everything from ALS to angelman syndrome to Alzheimer's disease, Kabuki syndrome, glucose transporter syndrome a number of other kind of even more rare things that you may not have heard of. Dominic D’Agostino: And, and we're also, you know, developing forms of ketogenic compounds, diets, and also supplements that would allow the war fighter and potentially even the astronaut to implement some form of ketogenic nutrition to enhance performance and resilience in extreme environments. You know, so going back to the, the Navy project, I've continued to be funded by them, you know, for like almost 12 to 13 years now. And I continue to have projects and we've developed the animal work and now we're actually doing studies in humans. And, and now we've actually moved on to working with NASA where we, eh, we do experiments where we live in an undersea environment for an extended period of time in what's called saturation. And when you're in saturation, it takes a long time to decompress and to come up. So your body is an extreme environment, not just pressure, but higher ATA of oxygen, higher partial pressure of carbon dioxide too, which has an effect. Dominic D’Agostino: So we have projects where I look at the gut microbiome, psychological testing, body composition. We look at a number of other factors, you know that are influenced, you know, in these extreme environments, a lot of like psychological, what we call team-building or cognitive team cognition. So how the group works together and that can be impacted by our energy state, our metabolism, and our pharmacology. So we're looking at a whole suite of parameters of people in these environments. So we figure out where the detriment is. And then once we understand that, then we develop a sort of a lifestyle, which is micro focuses, nutrition and supplementation to basically enhance, you know, resilience in that environment. And that would be physiological resilience and psychological resilience. So that's, we're putting a lot of time and effort into that project now. Wade Lightheart: That's pretty exciting stuff. Yeah, no I just wanted to comment on that. And one of the things I think from a practical standpoint that I think people can relate to. And I'm curious about this one because I think as listening to you on Tim Ferris, you had gone an extended period time of fasting and were able to like do a ridiculous deadlifts set. Do you want to talk about that just, just briefly, cause I'm just, this is a curiosity component of I heard about it. I want to be confirmed that I heard it correctly. So I'll let you speak from the hearts because what it seems that you've been able to do is something that almost no one would believe possible. Dominic D’Agostino: Well, I, I don't, I don't think fasting or being in it, and I don't think the ketogenic diet has, some people didn't accuse diet will dramatically impair your strength and performance and once you're adapted, and I don't see that as being necessarily a problem if you have protein a equate for protein and total calories. So fasting is sort of like another thing, but also kind of similar in a fasting state. It after about the second or third day it gets hard around that time, but once your body adapts you actually feel better. Your energy level starts to get a little bit low. Towards day five or day seven in me. I haven't went beyond a seven day fast. And I realized that, you know, I wouldn't want to do a high volume workout during that time, but I realized that my, my overall strength just by how I felt really was not impaired much in a, I just wanted to, you know, kind of feel how the weight spell on my body and actually my inflammation was gone. Dominic D’Agostino: Like, I mean, I felt good in so many ways that I just kept adding weight. One 35 to 25, three 15 four or five, four or five easier than I expected. So I was like, okay, let me try five plates. And I did five and I was thinking maybe I should stop there and my body's sort of in a low energy state and I just kept going. I normally can do more, but I, I felt that the 10, I don't even think I got sore the next day. But yesterday actually I just, I got back from traveling in Australia and I picked up a stomach bug on the last day as I really didn't eat for about two or three days. And yesterday I just posted it on Instagram, Facebook, I deadlifted five plates for 15. And my body weight was really low to one 98. Dominic D'Agostino That's extremely low for me. I'd be, haven't been that low since I was a teenager and I was kind of in a backseat state again. And again, I don't for exercises, like if for things pressing movements, if I lose weight, my, my strength goes way down. But for things like deadlift, I always kind of feel strong in a semi fasted state. And I think I've mentioned this to Tim's brand and Tim friend told Tim and then he unexpectedly added it to that podcast and it's like, I don't, I don't, don't, it's like, no, no, I think it's, you've got to start off. That's how you engage people. So I requested it not, you know, I mentioned that, but he mentioned it and it's like, then I had to live up to it, then I had to actually go and do it. Wade Lightheart: That's a fascinating, it's the next fascinating segue cause it's a pattern interrupt for most people who think three or four hours without eating, they're going to die. Especially bodybuilding six times a day probably. Yeah, exactly. So it's a point of interest. I think that kind of, you know, creates another level of curiosity for people to find out, well, well how is that possible? What is this guy doing? You know? And, and it, I think it just adds a a level of verification about the efficacy of what you're doing and what you're promoting and, and, and how you're going about doing it. It also opens a door, I think, which Matt's going to dive into here about asking some very specific questions because as is, he'll reveal he's, he's been deep down the ketogenic adventure for as long as anybody I know. Matt Gallant: So, so I want to get into I guess some nerdy stuff and you know, one of the things I believe in, I'm curious what your thoughts on this phone is that if we look at health as a spectrum on one side you got, you know, sickness and then your death and that in the middle what people call normal. Wade Lightheart: And then at the very end of the other side you have peak performance, peak health. So what I've seemed to notice is that all the things that might fix health issues, you know, for that get us from no sickness to normal will typically also get us from normal to a peak state. And you know, I want to get into the neuro cognitive enhancements that happened with the ketogenic side and you really want to understand what's happening exactly, again on a brain level and on a nervous system level that is producing enhancements. Like why, why is ketones enhancing the cognitive side? Dominic D'Agostino: Yeah, that's a subject of intense research and numerous labs right now. We have garnered sort of a lot of information over the years. Well personally doing it myself and actually measuring my neurotransmitters and, and other blood markers of metabolic health and inflammatory health and neuroinflammation. Matt Gallant: So can I ask you, like what have you seen on a neurotransmitter level? Wade Lightheart: Yeah. And what tests are you running. Dominic D'Agostino I Oh, have different kits here in my drawers. I was going to say that for neurotransmitters, it's not a great test, but one of them that I did, and I did a couple ZRT labs has a urine neurotransmitter test. And I think when I did it down inside the habitat for the NASA emo mission, a couple of them for some reason didn't come out. But the things that came out and made a lot of sense you know, I've, I've done repeated measurements and my GABA to glutamate ratio is very high. It's on the order of two to three times outside the range of normal. So I tend to, at least in a ketogenic state, you make the neurotransmitter gamma-Aminobutyric acid GABA you make, it's a brain stabilizing your transmitter. You actually make that from an excited Tori neurotransmitter called glutamate through the an enzyme called glutamic acid decarboxylase and being in a state of nutritional ketosis with the diet and now we know with supplementation activates the GAD enzyme to convert more glutamate to GABA. Dominic D’Agostino: So you go from a a state of the brain that's hyperactive in the context of what we study. There's excitotoxicity, glutamate, excitotoxicity and it, I think it's in part therapeutic because you are reducing in neurotransmitter that's causing a neuronal hyperexcitability and making GABA, which I don't want to get too down in the weeds, but it mediates, it does chloride mediated post-synaptic inhibition, which it opens up an ion channel that hyperpolarizes the membrane potential of the cell. And when a membrane potential is hyperpolarized, it doesn't fire action potentials as fast. It's more, it's very stabilized. And if there's lots of glutamate excitatory, that will deep polarize the membrane potential and it comes closer to its threshold for firing. So it starts firing action potentials very fast. And if all your neurons are doing that, then you're like dumping glutamate, you're dumping potassium, you're dumping calcium potentially. And this can create a scenario where you have excited toxicity. So in a nutshell, what being in nutritional ketosis does is it changes the neuropharmacology of your brain to prevent you from entering that hyperexcitable state. And so that's one of about a dozen things. And I could go down that sort of list of that on a dozen different things. Another thing that we can, Matt Gallant: No, but that's, that's, that's fascinating. Cause I've done some tests and I'm on the slightly deficient side of, of GABA. So it's probably one of the reasons why I love keto in general and, and why I respond well in that I did not know it what you just reveal. That's fascinating. Dominic D’Agostino: Yeah, we've published that too actually in well it's been published in Humans. But we, we did it in a model of Angelman syndrome and we actually have an Angelman syndrome clinical trial at Vanderbilt right now because of, you know, some of this, the work that we did in preclinical models. Matt Gallant: So a question. I mean when obviously common belief is that the brain runs on glucose, what's your answer to people that go with that? Dominic D’Agostino: Well, you know, that's what I was taught, that that was part of my training in nutrition. You know, you never go below a 60 grams of glucose because that's what the brain's obligate requirement. But then because I got interested in fasting, I was thinking, well, like what does happen when you fast? And I was thinking you know, well, how can people, how can people fast and not go hypoglycemic? And then I started reading a work of Dr. George F Cahill from Harvard medical school where he facet subjects for 40 days. You know, towards the end of that, he injected them with insulin to push their glucose down farther. And it revealed that they were asymptomatic for hypoglycemia because they're the fact that their bodies are adipose was releasing for energy to be used by skeletal muscle and the heart, the brain really doesn't use these large fat molecules for fuel because of the blood brain barrier. Dominic D’Agostino: So the liver converts them to small water-soluble fat molecules. We call ketone bodies or fat derived molecules. And then the ketone bodies can largely replace glucose as an energy source. Although we still our blood glucose levels, they're very powerful homeostatic mechanisms that maintain our blood glucose levels. So glucose really doesn't change all that much. It'll go down to like maybe three millimole or something like that at the glycerol backbone of triglycerides. We'll make continue to make glucose. And then you have gluconeogenic amino acids, especially Alanine that gets released from muscle tissues and that becomes can become glucose. But the primary fuel for brain energy metabolism can switch to from glucose to ketone bodies. And I say that I say primary fuel because more than 50% of brain energy metabolism, it's kind of universally agreed that after prolonged fasting that we are using primarily ketones. And the same thing can happen with a, a strict clinical ketogenic diet. You're primarily running the brain off a ketone bodies. Matt Gallant: So, just to recap, your body has a lot of different ways to internally produce glucose, which is kind of a fascinating cause I've noticed that too, that even when you know, zero carbs, carb or fasting, that, you know, my blood glucose might drop as, you know, high seventies, but it's, it's, it's hard for me to go lower than that even if I'm zero carb and fasting and what not. So, yeah. Have you noticed too that the longer, and I've seen some interesting research recently on this that if you're, it'd been on keto for a long time. That seems to be another level of adoptation where even while you're exercising, the glucose is staying in the muscle. Like the body's actually not even touching some of the glucose, cause I've noticed that even in the last like year or so that I, I just seem to be holding onto more glycogen in the muscle than I used to, even when I'm doing all the same things. Dominic D’Agostino: Yeah. That'll be dependent to some extent on calories. So if calories are if you're, you caloric and you're not at a calorie deficit actually, well I'll come to that later. But if you are, if you do become at a calorie deficit and you're carb dependent, you lose glycogen really fast. If you do become calorie deficit and you're adapted to a ketogenic diet, you, you, you lose glycogen much slower because you are using fat for energy or more fat. The ratio is higher than the ratio of glucose you're using. So, but yes, I think Jeff Bullock has published on these two and athletes is that skeletal muscle glycogen, not liver glycogen, but skeletal muscle glycogen does not change that much. And athletes that are extremely carbohydrate restrictive with their diets, which is difficult for some people to believe. But once you understand metabolic physiology and that we've had adapted the skeletal muscle, the primary engine, you know, that's, that's burning and a substrate to using fatty acids for fuel that actually has a glucose sparing effect and the glucose sparing effect because you're using more fats as opposed to glucose will preserve muscle glycogen. Dominic D'Agostino: Over time there becomes a tipping point. And I think everybody's a little bit different. But I think the point is that, you know, athletes that are, that are adapted to nutritional ketosis really do have a remarkable ability to retain also glycogen. Matt Gallant: So one of the big concerns that some people have and Wade has this concern as well is the loss in kind of, let's just call it the, the last 10% like that peak, especially if you're more of a power athlete. What's your opinion on that? Is that something that if you're fat adapted for long enough that you can regain? What have you seen as far as peak performance, again from a sprinting, weight lifting, those types of athletic endeavors? Dominic D’Agostino: Yeah, these are really good questions. You know, I do believe I've seen enough data to suggest that if you are on a very carbohydrate restricted ketogenic diet and you push an athlete to two dates, extreme short bursts of, of output, total power output may be compromised would likely be compromised to some degree. If someone's on a very restrictive ketogenic diet if you don't add carbohydrates in. So I think, you know, there, there's a lot of nuances here but, but I think that if you take the average athlete who's carbohydrate adapted and adapt them to a low carbohydrate diet forcing their body to sort of burn preferentially more fat for fuel, they can get 80 to 90% of the benefits of low carb without compromising their glycolytic capacity. And you can do this simply by titrating in the carbohydrates back into the diet. Dominic D’Agostino: A tip, you know, low glycemic index carbohydrates, small amounts of carbohydrates will keep glycolytic pathway sort of open various enzyme systems like every big dehydrogenase complex. So that enzyme, the people who favor high carb diets will say, well, your pre-rebate dehydrogenate complex will be suppressed. You won't make as much protein and that the enzyme itself won't be as active. I think one way to keep that, that energetic path open is to periodically add some carbohydrates in, maybe in around your training. And that could be beneficial too. And also if you are, if you are a low carb athlete, when you fuel up intro workout, the type of workouts I do, I don't, I don't really have a fuel up if I, I work my workouts are like 15, 20 minutes or something. But for athletes that work out for like hours at a time to then introduce a sort of a, you know, a carb and a bat sort of supplement at the same time like MCT oil or maybe even mixed with some long chain fats but also a slower burning carbohydrate source after a certain point because you do get carbohydrate, you know it does become a limiting substrate under some conditions and I think each person is a unique metabolic entity. Dominic D’Agostino: I need to experiment, but like the take home messages that if you go on a super strict diet, your low end maybe knocked down a little bit. But if you learn how to use carbohydrates as a performance enhancing substance and you use it sparingly, then I think you can get the best of both worlds. From, from my perspective. Matt Gallant: Yeah, I've seen, I know some guys that have tested their, their, their ketones by doing some cyclical carb re feeds, intro workout, and you know, they've gone as high as like 80 grams on a leg day and had no changes. So they've been able to just maintain ketosis. And because obviously in a squat day, you know, the big deadlift day, you're just going to be burning that glucose in real time. Dominic D’Agostino: The keto community may like cringe at this, but I, I really believe that carbohydrates are a powerful performance enhancing sort of substrate. If you strip strategically and if you deliver a certain types of carbs. I mean, it could be any kind of carb. I mean, when I experiment, I'll use chocolate. I mean, I'll, she's like stuff like that. So it doesn't really have to be a particular kind of carbohydrates, but if you add also lots of water and sodium too, while you're delivering the carbohydrates your blood volume will go up. I mean, you'll notice things in the gym, you know the energy that you feel may just be due to the hyperhydration you get and it doesn't take much. So that's the key. You don't have to throw in like three, 400 grams of carbs and it can be as little as 30 or 40 grams of carbs. If you're a really big guy doing a long workout. Yeah, you might want to titrate, you know, 80 grams of carbs over that duration and maybe a little bit with a refeed. But it certainly doesn't take a lot of carbs to when you're talking about someone who's fat adapted and the, I think 30 grams of carbs for the typical, you know, one, one and a half hour workout, however long people work out these days. Matt Gallant: So you really open up a topic that I had in mindful on time, which is the idea of dual fuel, right? So the idea that you can both run on glucose and ketones simultaneously. I mean, I've done it personally many times. Can you, first of all, can we start with the physiology? Like, how, how is that happening? How is the body burning both glucose and ketones at the same time? Dominic D’Agostino: Yeah, there doesn't seem to be like, it's a strange question for me, like someone who studies physiology because I mean it's just, that's what the body does. But I know there's two camps out there who just kind of believed that, you know, we fuel off carbohydrates or refuel off ketones and fat. But your body has in your brain. We now know, has amazing metabolic flexibility. So if we adapt our bodies over time, and the best way to adapt is to train under specific metabolic conditions. So training while you're fasting periodically, I mean, some people cringe at that, but I think doing it occasionally is a good idea. Training in a state of nutritional ketosis occasionally throwing carbohydrates in so your body recognizes that fuel and to do that periodically. So I mean, I'm coming at a, at a neuroscience perspective because I, I believe a lot of our digital output and our brains are wired to our muscles. Dominic D’Agostino: So if our central nervous system is energized and we have good fuel flow to it, it's going to buy our muscles and can attract more muscle fibers so we can actually get stronger contractions and maintain that over longer periods of time. If we give, our brain has metabolic flexibility and we'll use whatever fuel is available. So glucose and, and ketone bodies we know it can use lactate to a little bit amino acids, but usually, you know, glucose or ketones. So it will use whatever's available and whatever's in the blood. So one strategy could be to do a carbohydrate-based diet that you know, low enough that you maintain optimal insulin sensitivity and then throw in ketogenic nutrition, which could be MCT oils or on supplements without necessarily restricting carbohydrates to the point where you are in ketosis. A MCQ oils can achieve that. Dominic D’Agostino: And also ketone supplements on the market can also achieve that. This is a new idea. But we do know that independent of a carbohydrate restriction, if you administer a ketogenic agent, whether it's a ketone salts, even MCTs or ketone esters, the body will use what's available. So if you elevate that substrate, interestingly, if your ketones are elevated, it seems to facilitate a glucose disposal into the tissue to although it, it kind of appears that because your blood glucose goes down when you administer acutely a ketogenic agent, some individuals, some labs believe that that's an increase in insulin sensitivity that's facilitating glucose disposal that could be happening. But I think when you orally administer a ketogenic compound through counter-regulatory mechanisms, we don't quite understand. There's a decrease in hepatic gluconeogenesis and thereby a paddock glucose output is reduced. We have not done a liver metabolics to figure out what's going on, but it kind of makes sense that it delivers, you know, seeing a high concentration of ketone bodies, it's going to want to spare glucose. Dominic D’Agostino: The glucose you have in your blood now is not like it's the glucose that your liver regulates. So your liver is the master regulator of the glucose that your peripheral tissues seats. So the glucose that's in your blood now, it might be from a couple of days ago, the glycogen that's stored in the liver a couple of days ago. So your liver is like the master regulator. It's why it's important to keep the liver healthy. And when the literacy is ketones, I think that it's a decreasing glucose output. This is important therapeutically for like type two diabetes and also, but it's also kind of important too from a fuel, a dual fuel perspective, which was the question I think people will ask, well what will happen if you throw ketones on top of glucose? You know, then you're just, you're creating this artificial scenario, which could be dangerous. But I believe that, well, we now have experimental data to show that the liver does a pretty good job at recognizing it. Dominic D’Agostino: You know, the, the level of ketones that you have and, and utilizing those fuels and people maybe look at exogenous ketones as an artificial fuel, but it's really just another energy source. I mean you could say that it's creatine, right? I mean, we take or we make creatine, we store it a little bit and when we drink it, we're getting super physiological levels. And from the literature all we can tell it's doing positive things. And I think ketones are kind of like it's good to make them through our own physiology because that forces adaptations and adaptations are necessary for the ketogenic process, that ketone transporter process going across biological membranes. And also with cell C ketones, you're also up regulating keto lit enzymes which allow cells to derive energy and ATP from the ketone molecules. And I think that happens faster when you do it naturally with the ketogenic diet or fasting. And then if you throw ketone supplements on, you know, sparingly. I don't, I don't use em today. I don't use them every day, but I think you can kind of gain, you can kind of gain the system a little bit and gain an advantage. I mean, what our research shows. Wade Lightheart: I can, I would echo that from just a clinical conspiracy, my own stuff. Matt, of course, has been on the ketogenic diet. I'm a, I'm a plant based guy and, but I have an extraordinary blood insulin response, you know, whether it's genetics or whatever. I, you know, when I measure myself, I'm often in a ketogenic state almost when we do our typical fasting on a HomeAway or that sort of stuff. But when I've added ketones, exogenous ketones that Matt's provided for me I, I noticed an instant cognitive performance benefit. Like it's like, okay, I'm a little sharper, everything's a little, little, little crisper and the endurance factor seems amplified for sure. So I, I would echo that just, and that's not very scientific, but it's certainly experimental. And I, and I'm curious, do you kind of do these experiments on your own and then start doing the data and kind of like hitting your bio feedback and then go, I didn't, let's dive into this and see if this is true. I'm just projecting. Or is it you come up with a theory you do in the lab and then you go the other way? I'm kind of curious which way you like to go. Dominic D'Agostino: Well that's a good question. It goes both ways sometimes. And when I got interested in fasting and I read the Cahill studies, then I was like, okay, I gotta do this myself. You know, I gotta, you know, I'm not going to do 40 days, but I'll do a week and see what happens and do the blood work and things like that. And basically all my health markers improved, kind of as you guys would expect. And you know, and as we develop things in the lab, like synthetic ketogenic agents, you know, we'll use them experimentally and sometimes I, you know, take a little myself through the years and, and so some of the things that we use are not, you know, they are experimental compounds right now, but they are tracked towards a clinical use. And once you tinker with these things, then you start to realize some of their potential, right? Their therapeutic potential because some of them like you can actually feel you know, quite remarkably with a acute administration and it's not acting like stimulant. It's not, you know, you're not mixing with caffeine, you're just, you're just elevating the level of available fuel that your brain sees and that has, that has an effect. Matt Gallant: I have a question on that. Cause I usually a twice a year we, we go and do some really extensive hardcore difficult brain training. It's about six hours a day of pushing your brain to its absolute limit, be the equivalent of probably running a couple of marathons a day. And I D I did the first couple of times without ketones and then we started adding like, you know, 30 to 60 grams of esters a day and that allowed us to just continue training cause usually your brain crashing by day three, day four, you know, Wade and I've gone through that. But with the, with the, with the testers, there was no crash. Like day four, day five, day six. I mean you're, you're kind of getting tired, but that's more of a nervous system, you know, but at the same time we were able to continue the training, but the thing that really blew my mind, and I don't understand the, what's going on was the recovery. Like yeah, it gave me a little more energy, but what I really noticed was one, it seemed like I needed almost less sleep taking that many ketones and that I just felt relatively fresh the next day. Again, even despite pushing myself. So from a recovery standpoint, like why, what's going on there? Dominic D’Agostino: Yeah, that's a good, interesting observation too. If you collected data on that, it'd be good to put that together. I, I guess going back to the experience that I can draw off of where I've quantified things to as much as possible would be the NASA extreme environment, mission operations NEMO 22 where a lot of people think I use ketone supplements like every day because we kind of, we're kind of like the people who brought them to market. It mean like Patrick Arnold actually had and you know, years ago and, and different companies or some now. But you know, I don't use ketone supplements every day, but I did during that mission, especially doing the EDAs, the extra vehicular activities and things like that. And for morning multidose and Europe day and and I experimented with in the past. And what I do consistently notice getting back to recovery is that if I'm in a state of deep ketosis I do tend to sleep a little bit less. Dominic D’Agostino: Like lately I've been sleeping like eight hours, sometimes not, but I could sleep about six and a half. And then my amount of deep and REM are the same. So the restorative sleep that I'm getting when my body is in a state of nutritional ketosis seems to be better. So if you have ketones, if your brain has ketones available we now know that the carbon backbone of those ketones are part of the biosynthetic process of making neurotransmitters. Like alpha-ketoglutarate for example, is the precursor to glutamate is the precursor to GABA. And this is called an anaplerotic pathway. So the try-carboxylic acid cycle or the Krebs cycle and the cycle of the NSX make you make the Murray Mallee etc. All these, the, we have demonstrated through metabolomics that these become elevated and you are sort of driving the biosynthesis of neurotransmitters by virtue of increasing TCA cycle intermediates. Dominic D’Agostino: So I believe that this is accelerated a bit because you have the substrate available, you have more precursors can make neuro-transmitters when you sleep. Also, if you're in a state of ketosis, our astrocytes, so we have neurons and we have astrocytes and there's other cells like, like oligodendrocytes and other. But if we just talk about, you know, the two main cells, neurons and astrocytes, the astrocytes tend to store energy in the form of glycogen. When you're on, when you're in a state of ketosis, the ketones will spare just as it does sparing muscle glycogen. The ketones will spare that glycogen in the astrocytes. And part of the restorative process of sleep is to restore the glycogen levels in the astrocytes. So because you're using ketones, you don't have to kind of restore a glycogen levels. So I think that's something. And also there's something called the glymphatic system. Dominic D’Agostino: So your brain has a system that is activated. It's activated all the time, but more so when you sleep and there are things ketones can enhance brain blood flow by 30% with an acute when you acutely elevate ketones with like different ketogenic competence. So I believe that that increase in blood flow and other other factors that are associated with ketosis will increase the glymphatic system performance, if you will. And we'll get a, and this needs to be tested. It's just my, my speculation is that you're enhancing astrocyte glycogen neurotransmitters synthesis and also the glymphatic activity while we sleep. Makes sense. That's a multi-day thing that you're doing. So you're looking at it. So sleep is what would be really important. Matt Gallant: It's critical and we're running dual fuel during that time. So like I'll, I'll, I'll eat a little more carbs. So actually running dual-fuel seems to help. Your thing it seems to help too is like I'll, I'm not a big branch chain amino or amino guy, but adding aminos. So I'm taking 60 grams of ketones, taking like 20 grams of aminos. Plus I'm eating carbs and a lot of good fats as well. And it just seems to help on a lot on all levels. One question that I've had in a, and I haven't seen too much research on this, but experientially I've certainly noticed that. What have you seen in terms of the types of fats and their ketogenic response? Cause for an example, like if I eat animal saturated fats and I measure my ketones, especially like things like pig fat or that it definitely seems to produce more ketones then, you know, monounsaturated, you know, like just different fats seem to produce a different ketone response. What have you seen around that? And, and do you think that's important? Dominic D’Agostino: Yeah, so that's an ongoing question in a ketogenic diet. Well, it should have been ongoing for like 20 years, but only recently are they kind of recognizing that, you know, different fats have different effects. It's not just like macronutrient profiles. And I think it people will have, people have different food sensitivities. So some people who have a dairy a mild dairy allergy, if they take a dairy-based spat it the, the activation of the sympathetic nervous system or various immune factors may actually prevent ketone production. You know, so that's, I found that mildly in myself. But I kind of going back to your observation, I think a fat in the form of butter, you know, a meat fat like pork fat be fat and to some extent maybe chicken fat, these all contribute to very stable, predictable ketone production and meat. And when I tried to sort of mimic that with more of a plant based, I could get my ketones elevated, but it's a little bit less predictable. Dominic D’Agostino: But I think that's primarily because of sort of the plants that I'm getting the fat from. Like nuts, like macadamia nuts and almonds and avocados. You're delivering fiber with it too. So sometimes I can get my ketones elevated to the same extent. And sometimes I think because the natural fibers that are in plants are maybe preventing the release of the fat. And it's going through me. I know if I like a lot of raw homage or something like that, I'm definitely not absorbing all those fats, you know. So if I eat an equivalent amount of fat from raw almond as opposed to pig fat and I acutely do it, I eat the meal and then measure fat. There you're keeping on production will be like proportional to the amount of fat that the liver is seen, dietary fat. So it's kinda hard to quantify that. I guess you could use plant oils and things like that, but Matt Gallant: It seemed that though of course there's the neutrogenomic aspect, there are certain certain genes that obviously seem to indicate better saturated fat breakdown and so on and so forth. So there's probably a pretty strong genetic component to that question. Dominic D'Agostino: Absolutely. And you know, I sh I would like to know more about that and I try to keep up on that as much as possible. I have my own 23andme data and just looking at, you know, putting it on different platforms. I kind of know what works me just through experientially and I know some people have, you know, they have different snips that prevent them from, from metabolizing fatty acids as efficiently as possible. And it may not be an honor off kind of thing, but on a spectrum, right. And some people are just poor oxidizers or metabolizers of fat, so they will if they eat a high fat diet of animal fat, they feel sick, they don't feel good and their triglycerides go up and then does it come down over time. And I would tell that person don't do an animal based. Dominic D'Agostino: You know, and some people feel really good on a, on a plant based diet and all their health markers improve. And you know, I don't know if they give the ketogenic diet enough time, but cause your body does need to adapt to that over time. But I'm not one or the other. But actually I probably eat an enormous amount of plants and I have lots of and I do believe that they should sort of be in the raw form as much as possible. A lot of broccoli, asparagus, cauliflower, things like that and a big salad pretty much every day. And then I add a fatty beef, chicken or a lot of fish and eat a lot of fish in our house to that salad typically. And then maybe add oil on top of that in the form of avocado oil, macadamia nut oil, olive oil. And then I mix MCT oil with the salad dressings too. So I find that the optimal way to get my ketones as high as possible. Matt Gallant: I mean, Wade is the king of the big ass salad. He is, you know, we had introduced me to that know 20 years ago when we were both living in Vancouver and a half to say. And usually I'll try to do at least one big, a solid a week that just like another energy component that I feel from, I don't know if it's a phytonutrients or what's going on exactly. But you know, it, it kicks her, it just kicks something in. So wait, I mean maybe talk about your big ass salad strategy. Dominic D’Agostino: Yeah, I'd like to hear that. I mean, from a, I'll add this real quick if you, cause there's a lot of people are carnivore now and they do one or the other, but if you put your meat, if you eat it with a salad, the fiber from the salad will delay gastric absorption. And also it's aiding your gut microbiome, especially if you have a diverse array of things in the salad. And that's actually enhancing. It's decreasing your glucose and insulin response to the protein. But but I also think it's promoting, you know, healthy digestion, optimal gut microbiome. So I'm just kinda throwing it out there because I dunno, I just posted something recently and someone said, I'm killing myself by eating plants or something because plants are trying to kill you. So it's like, Wade Lightheart: Yeah, that's a pretty extreme position that something Wade Lightheart: We have adapted convenience land. Like wow, I didn't know my salad was so dangerous. Yeah. I've, I've been a big proponent of, you know, there's this certain, you know, when I go, I go to obviously whole foods and things like that to the salad bar, especially when I'm on the road. That's my first stop. And there's something I, there's two things that I think are anecdotally interesting. One is I noticed they're at different times I'll be attracted to different colors. Like I like and, and, and I always indicate to me that there's some sort of mechanism that's letting me know that I need to get more beets today or I need to get more cabbage or whatever it happens to be that. And so I always find it interesting about the colors. The second thing that I've noticed, it was without a doubt, and I'll be going to whole foods right after this call in variably I make these giant sounds like I get the big green bowls at the whole foods that they have them and it's piled up and it's 30 bucks or whatever for my salad. Wade Lightheart: And every single time somebody in the lineup or the cashier will comment that and say, that looks amazing. And I find that's a very interesting response that it's so across the board that there's seems to be some sort of internal recognition that that's good or that's healthy or that's something that I'd like to try. You know, cause it's obviously a ridiculous salad, but I think there was a good point you brought up was the fiber relation to insulin response or the use of fats. And it's, I believe it's one of the reasons why I have such a great insulin response to spite the fact I'm on a plant based diet. I eat a ton of carbs. Yet when you do my testing, it's like, it looks like I'm on a ketogenic diet from a, from an insulin response. Any other comments on your work? Dominic D’Agostino: It doesn't surprise me. I mean, you know, all those vegetables are carbohydrates, right? So as you would expect an increase in glucose, but if you have a steak and then you have that same steak with a big salad you will have a less of a glycaemic response and less of a rise in insulin too because it's the fiber is delaying gastric absorption to some extent and just delaying the breakdown and release of amino acids into the blood. And and I think it's even more pronounced if you add back to that salad. I actually think of in ketogenic diet formulation, the vegetables are a way are a fat delivery vehicle. So you could lightly steam vegetables, saute them, and then add a lot of fat to that or a salad. You can add a significant amount that to that you can add up condos and nuts and olive oil or a mixed oil dressing and then deliver in a relatively small salad, you can deliver 50 or 60 grams of fat. Dominic D’Agostino: So that, that's, that's important clinically. And this, these approaches are now being used and to keep the genic diets that are having better outcomes as far as seizure controls or metabolic management of particular disorders. And it kinda goes against what was traditionally that the carbohydrates need to be below a certain level. You're adding a lot more carbohydrates in the form of these essentially non glycemic fats, but the fiber and the phytonutrients and other factors are greatly helping to actually induce and sustain ketosis. And you're actually probably significantly enhancing the nutritional status of that patient too by not, you know, eliminating plants, which some ketogenic diets do, but actually being very liberal with your plants consumption, which I think as our nutrition evolves, we need to start incorporating more plants into ketogenic diets. Wade Lightheart: Sounds like there might be an actual unification between ketogenic and plant based diet. Yeah, I'm on that. I'm on that train because you know, we're just into optimal. What is the optimal diet for any given person in there, any, any given lifestyle and something they can sustain. So yeah, great, great to hear that you're on the bleeding edge of that. Matt Gallant: Speaking of optimal diets, I mean when one thing I'll share is I optimize my big ass salad using VIUM data. So the VIUM data is, it got tests and you can send them a school sample and it tells you which foods you should eat, a lot of which food you should eat less of. So I decided, you know what, I'm going to build like a super salad kind of just with the foods that it's saying or should eat a lot of. Matt Gallant: So for example, watercress, rucola those came up because I, I guess I have the gut biome that breaks those foods down. So what was really fascinating was despite eating like two pounds of, it almost sounds about two pounds. I would just incinerate it, like almost nothing would come out and like even my weight would go down. It almost like it almost defied science in the sense that it's like, okay, I'm meeting two pounds, almost nothing's coming out and my weight would drop. And, but if we look at it from a gut biome perspective where they're eating all, like I'm feeding all the bacteria that I have and they're just devouring that food, then it does make sense. So I just wanted to share that anecdotal story cause it kind of surprised me so significantly. You know, it is to shift gears here. You know, to talk about a subject that I think is, is near and dear to all of our hearts, which has cancer. I lost one of my best friends and recently an Matt Gallant::Aunt and an uncle and I like Wade to share his story about his experience with this. And then I love to get into what you've seen as far as ketosis, ketones and cancer. But Wade, why don't you share your story? Wade Lightheart: Yeah. So for those who don't know my sister died at the age of 22. She got sick with Hodgkin's disease of formula lymphatic cancer and progressed over four years. When I was young, it had a big impact, got me into kind of physiology and exercise and performance. And I've been graced now to actually serve as an advisor for the American Anti-Cancer Institute. And we help people who are either going through cancer or recovering from cancer to, to, to make better nutritional solo selections and to prevent it in the future or to optimize their diet. So it's something I'm really, really passionate about. And I'm curious what you have kind of revealed, cause I think one of the, one of the things you talk about was the death at cancer. The, the powerful effects of both the ketogenic diet and its relation to the pre cancer prevention or even as an augmentation. What, what, of, what's kind of fueled that and what have you learned and how can people who may be in one of those situations, where would they go and how would they start researching and for the self to kind of create the best survival situation for them? Dominic D’Agostino: Yeah, that's a, well, it's kind of a long story, but I'll make it as short as possible. Some of the, some of the technologies that we developed for the office of Navy research allowed us to look at a variety of cell lines. And one of them was a equal glioblastoma, a cancer cell line. And I made two observations. One was that high pressure oxygen killed the cancer cells faster than normal healthy cells. And that was because cancer cells had a dysregulation in their mitochondrial function. And if you hyper oxygenate them, they divert more molecular oxygen to super oxide anion, which is the precursor free radical that can go on to other radicals that can basically trigger apoptosis and cells. So we observed this acutely and I thought it was interesting and nobody had observed it before because they didn't have a confocal microscope inside a hyperbaric chamber. Dominic D’Agostino: So so this was like, I was curiously interested in that. And also when I grew cancer cells under different substrates, including low glucose or high glucose in particular high ketones, the ketones suppressed the growth and proliferation of the cancer cell lines I was looking at. So I made, I made two observations studying a military project, which is oxygen and how high oxygen high ketones are bad for cancer. So, so a, a PhD student came along and actually this became a PhD. She's now Dr Angela Pop. And throughout her PhD studies in the lab, we observed that a ketogenic diet with hyperbaric oxygen therapy given three times per week suppressed the growth of a cancer in a particularly aggressive form of metastatic cancer, a model of metastatic cancer that we had in the lab. And you know, so it, it kind of begs the question then, how does a high fat ketogenic diet, how does that contribute to suppressing cancer growth? Dominic D’Agostino: And proliferation and it does it through a number of different pathways. One is that we understand now we actually did back, you know, in the 1920s and thirties, that cancer growth is primarily fueled by glucose and cancer cells preferentially use a higher consumption glucose than normal. Healthy cells do. And we can, we can use a fluorodeoxyglucose pet scan oncologists use a pet scan to image the location and aggressiveness of cancer, but they don't really use that information to target the cancer. But we can, we can share through our best imaging techniques that, that there are consumption of glucose a hundred times higher in certain cancers relative to the healthy tissue that's surrounding it. So it's out competing the healthy tissue to get the glucose. So it keeps a genic diet restricts glucose availability to some extent, right? We know baseline glucose doesn't change all that much unless calories are restricted. Dominic D’Agostino: But when you eat a ketogenic diet, there is a very minimal increase in blood glucose and insulin. When you eat at carbohydrate-based diet, there's a relatively high spike in glucose and insulin. Those spikes in glucose and insulin are abolished if not significantly attenuated on a ketogenic diet. So I think that's important. And, and really what's important, it's a suppression of the hormone insulin. That's how actually we make ketones. The ketogenetic diet works by suppressing the hormone insulin, maybe slightly increase in glucagon and that accelerates fatty acid oxidation in the liver. And that continual suppression of the hormone insulin is absolutely necessary for us to stay in a state of ketosis. Cancer cells are there, growth is driven by insulin. IGF1, PI3-kinase, AKT/mTOR pathway and a few other, you know, things related to that. So what the key to dining diet does is suppress insulin and insulin signaling. Dominic D’Agostino: IGF1, PI3-kinase, AKT/mTOR pathway is acutely and continually suppressed if you follow a ketogenic diet. So what that does is it takes the foot off the gas pedal of cancer growth. Most cancers are driven in growth and proliferation by this particular pathway. And that's why pharmaceutical companies are scrambling to develop drugs that target enter PI three kinase IGF one, things like that. So that the ketogenic diet does that naturally as this fasting, but that that can't be sustained. So what you do is create a scenario where you slow down cancer growth. The ketogenic diet is not going to cure cancer. So that's really important. But what you do is you see in some people it has actually, so I should kind of stop and there's anecdotal or it's an even case board, but most importantly it will slow cancer growth and make cancer a more vulnerable target for other modalities. Dominic D’Agostino: And those modalities could be chemotherapy, it could be radiation. We know from clinical data that chemo and radiation can be a lifesaving for many people there are things like advanced brain cancer and metastatic cancer where these things do not offer much of an advantage. But in the context that I keep a general diet, you may sensitize the tumor in a way or make it more vulnerable to make the cancer or the tumor solid tumor more sensitive to these modalities. And also immune based therapies to may work better in the context of the ketogenic diet where you are limiting glucose availability. So essentially what's that's doing? It's suppressing the glycolytic pathway. That's how cancer cells are primarily making energy, glutamine and glucose. When cancer cells do that, it activates a particular pathway called the pentose phosphate pathway. And that pathway develops, it generates reduced glutathione, and that reduced glutathione makes that cell like a super cell. Dominic D’Agostino: It can protect it against a chemo and radiation because it's, it's an endogenous antioxidant. If you inhibit the glycolytic pathway, you could do it with a Cuban drank diet. There are now drugs that inhibit glycolytic pathways. You crippled the cancer cells ability to defend itself by virtue of suppressing reduced glutathione. And so now that cancer cell becomes more vulnerable target, especially to modalities that kill cancer cells through an oxidative stress mechanism. And that could be various chemo drugs and also radiation. So I'm trying to keep it as simple as possible, but I think that the thing is that the, the, the ketogenic diet works through many different ways. I just described a metabolic way, but it also functioned that suppressing inflammation, which is a major driver of cancer. And then the ketone bodies themselves are epigenetic regulators by acting as class one and class two histone deacetylase inhibitors. So that's an intense area of focus now in our lab and other labs as ketones functioning as signaling molecules, even hormones, if you like, in ways that have anticancer effects by activating tumor suppressors and actually turning off or turning down a oncogenic drivers. So that's an area of intense interest right now that ketones functioning independent of metabolism as influencing various anti-inflammatory pathways. NF-Κb, NALP3 inflammasome, but also through epigenetic regulation. Matt Gallant: I'm gonna steal a question from Tim Ferris and see if your answers is different today, which is if you or a loved one had cancer, what would you do? Dominic D’Agostino: Find out what all the options are given the type of cancer if it's an option where, or if it's a type of cancer where the options are very limited in regards to the standard of care not being very efficacious, and if it's minimally efficacious, you have to evaluate the patient, you know, with their doctor, whether it's worth doing that. Right. So I guess the simplest thing to do is to use a what's called a glucose ketone index. So we know if we can normal glucose being five millimolar, say if we could bring our glucose down to say three millimolar and elevate our ketones to three millimolar, that would give us a glucose ketone index of one. So if our glucose stays at four millimolar and we get our ketones only at two millimolar, that would give us a glucose ketone index of two. Dominic D’Agostino: If you could maintain a glucose ketone index of one to two, even one to four, normal American is like 25, right? So if we can bring that down from 25, which is a glucose dominant metabolism to a glucose ketone index between one and four, again, which is glucose over ketones in millimolar concentrations. And in America we use milligrams per deciliter for some reason, but in millimolar concentrations, so get a GKI of one to four and that will slow cancer growth. Right? I think that's incredibly important. Evaluate the potential for drugs like Metformin. Metformin is available. You could jump online and probably get it. Metformin is when we started studying Metformin, there was maybe two or three clinical trials. Now there's about 200 clinical trials looking at the drug, Metformin as a means to enhance other

I'm starting the Daily Bites again, 5-minute jewels for those with short attention spans (or very busy!). Here's a clip from San Diego 2016 (sorry, sound quality was old school!). We sit with the brilliant Dominic D'Agostino who briefly summarizes some key points of evidence for potential utility of ketogenic diets as an adjunct support for cancer and other diseases. The full discussion is available here: https://www.youtube.com/watch?v=Ntob6Sn06_Q

Today's Best-Of Livin' La Vida Low-Carb features a 2014 interview with one of the expert contributors to the book Keto Clarity, Dr. Dominic D’Agostino. The world deserves to hear more about all the amazing health benefits that come from being in a state of nutritional ketosis. For far too long, the “k” word has been ostracized by the health community and the time has come to set the record straight. That’s exactly what our host Jimmy Moore has done with his brand new book entitled Keto Clarity: Your Definitive Guide to the Benefits of a Low-Carb, High-Fat Diet. Just as he did on his 2013 bestselling book Cholesterol Clarity, Jimmy teamed up with internist and Duke University low-carb diet researcher Dr. Eric Westman as well as 22 of the world’s best experts on ketogenic diets to offer one of the most readable, practical guides to all the reasons why you would want to start producing more ketones in your body. Written in Jimmy’s easy-going and relatable writing style, Keto Clarity also includes the familiar “Moment Of Clarity” quotes from the experts and “Doctor’s Note” entries from Dr. Westman throughout the book to strengthen the information being shared. We’ve got so many amazing BRAND NEW INTERVIEWS (these aren’t the same interviews Jimmy conducted with them for the book) about ketogenic diets and their impact on health to present in the coming weeks in celebration of this momentous new book release.

In this podcast episode, Dr. Anthony Gustin interviews Dr. Angela Poff, a leading keto researcher based out of the University of South Florida. Dr. Poff has worked with Dr. Dominic D’Agostino, another leading researcher at USF, for almost 10 years now to study therapeutic ketosis and cancer metabolism, along with other conditions such as seizures and neurodegenerative diseases. You’ll hear more about everything they’ve discovered along this research journey when you tune into the episode. Dr. Angela Poff holds a Ph. D in Medical Sciences from the University of South Florida, where she’s been researching for almost a decade now.  You’ll discover how Dr. Poff got into this space, why she’s so passionate about it now, and what she does on a day-to-day basis as a result of their research findings in this episode. Dr. Poff also shares her knowledge on ketones, ketosis on different cancer models, and how she modified keto for pregnancy. Check out the episode now to learn more!

Andrew Kornblatt sits down with Ocean Planet Conference organizer Dr. Armin Ellis and conference speaker Dr. Dominic D’Agostino for a reddit AMA.

Listen as Dr. Dominic D'Agostino teaches us about the ketogenic diet, nutrition, the link between healthcare and agriculture, and what he and his wife have learned while working on their sustainable and regenerative farm in Florida. Bio: Dominic D’Agostino, Ph.D., is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida (USF) Morsani College of Medicine and a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. D’Agostino received his B.S. in Nutritional Science and Biological Sciences in 1998 at Rutgers University before receiving a Predoctoral Fellowship in neuroscience at the University of Medicine and Dentistry of New Jersey in 1999. In 2004 Dr. D’Agostino entered into a postdoctoral fellowship in neuroscience at the Boonshoft School of Medicine at Wright State University in Ohio before moving his research program to USF Tampa in 2006. Funding through the Department of Defense (DoD) and Office of Naval Research (ONR) lead him to develop nutritional strategies related to enhancing resilience in undersea environments, treating neurological disorders and in brain cancer treatment. Dr. D’Agostino participated as a research scientist and crew member on NASA’s Extreme Environment Mission Operations 22 (NEEMO 22) and continues to work closely with federal organizations, private industry, 501c3 foundations and media outlets. Dr. D’Agostino and his wife spend a considerable amount of time working on their farm in Florida with a focus on sustainable and regenerative agriculture.

Returning guest, Dominic D'Agostino, is a researcher and professor in the department of molecular pharmacology and physiology at the University of South Florida Morsani College of Medicine. On today's episode, he offers fascinating insight into a recent mission he completed in collaboration with NASA, which involved a number of experiments carried out under sea with the purpose of emulating activities that are essential to space missions. He explains how different space analogs under the sea can mimic neutral buoyancy and microgravity in space, the use of mini DNA analyzers to analyze the microbiome of the habitat and surface of astronauts' skin, the physiological effects of hyperbaric pressure which presents three times the amount of oxygen and nitrogen than the average person is accustomed to, a number of extravehicular activities (EVAs) to include the testing of astronaut rescue devices and drills for sampling rock or coral, the health impact and ways of dealing with extremely high concentrations of carbon dioxide, and decompression sickness. He also discusses what he considers the biggest challenge in space, which is living in confined habitats for long periods of time. Navigating these issues means addressing team cognition and psychology, as well as the practical concerns associated with performing a variety of scientific experiments and tasks in such small and enclosed spaces. These are just a few of the subjects D'Agostino discusses on today's episode, and he brings an impressive amount of knowledge to every single one. Press play to hear the full conversation.  

Our guest this week is Shawn Wells, an expert in the field of performance nutrition and supplementation. He’s often called the world’s greatest formulator (of supplements). We talk about the problems with the Modern Western Diet or Standard American Diet, and how even if you’re getting plenty of calories, you’re probably not getting enough energy. We also talk about the purpose and benefits of the ketogenic diet and how to get started. This is great for anybody who is tired of feeling sluggish and feels like they have unhealthy relationship with food. Follow up with Shawn at his website or on Twitter and Instagram.We talked about Berberine as a supplement. Get it here.Also, check out our conversation with Frank Llosa and his supplement, KetoneaidAnd our conversation with Dominic D’Agostino and Dr. Anthony GustinThis episode is brought to you by Weider Artery health available on their website or at Costco.For more information on the MIT classes we discussed at the beginning of the episode go to: https://ocw.mit.edu/index.htmOwn the journals that Gib uses: The EVO Planner and a blank Moleskin.Submit your pet to be the pet of the week go to: teshvideos.comCome see us live: teshmusic.comAnd you can sign up for our newsletters at tesh.com to get Intelligence For Your Life right to your inbox.As always, if you like our podcast, Rate, Comment and Subscribe on iTunes, Stitcher, Spotify or wherever you get your podcasts. And tell your friends! If you don’t like our podcast, then keep it quiet, I guess.Our Hosts:John Tesh: Twitter: @JohnTesh Instagram: @johntesh_ifyl facebook.com/JohnTeshGib Gerard: Twitter: @GibGerard Instagram: @GibGerard facebook.com/GibGerard

Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer and metabolic wellness. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments.  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.   Time stamps   5:56 Nasa Neemo 23 17:38 Organization/entrepreneurship/ and prioritization. 19:38 Human Metabolism and the ketogenic diet. 29:07 Glucose Metabolism 31:06 Do we need glucose to run our body? 32:43 What changes in our body when we don't consume carbohydrates. 39:50 Medium chain triglycerides. 42:45 How do we adapt to ketosis? 44:52 Calorie restriction benefits of the ketogenic diet. 48:53 Neuro protective effects of ketones. 49:58 Anti-inflammatory mechanisms of ketones. 53:45 Histone deacetylase  56:40 Epigenome. 58:00 Krebs Cycle.  59:51 Mitochondrial Function with Ketones/oxidative stress.  71:17  Carbohydrate based metabolism and oxidative stress..  72:55 Mean amplitude glucose excursions. 76:10  Glucose, inflammation , oxidative stress and insulin resistance. 77:20 The Warburg Effect 89:35 Mitochondria Damage or nucleus damage in regards to cancer. 92:37 Ketogenic diet and Mitochondria protection. 94:20 The most radical thing Dom has done recently. 95:45 Where to find Dom online/upcoming projects.  Dom’s info: Instagram: dominic.dagostino.kt Twitter: DominicDAgosti2 Web: ketonutrition.org  Ancestral Supplements https://ancestralsupplements.com/ use the promo code “SaladinoMD” on the shopify site for 10% off.    JOOVV: www.joovv.com/paul   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram: @paulsaladinomd Website: paulsaladinomd.com Twitter:@mdsaladino Facebook: Paul Saladino MD email: paulsaladinomd@gmail.com   Be sure to subscribe for more medicine and lifestyle content. Stay radical!  

Dr. Dominic D’Agostino returns to STEM-Talk to give Ken and Dawn an update on his research into ketogenic nutrition. Dom was the guest on episode 14 back in 2016 when ketogenic diets didn’t even show up on a list of the top-10 diets that people Googled. Since then, the search term “ketogenic diet” has risen to the top of the list. In today’s episode, Dom talks about his past 10 years of research into ketogenic diets and what he is learning about the physiological benefits of nutritional ketosis. Dom is tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine.He also is a research scientist here at IHMC.Throughout his career, Dom has been a researcher with a diverse background in neuroscience, molecular pharmacology, nutrition and physiology. Show notes: [00:02:55] Dawn begins the interview mentioning that when she and Ken started hosting STEM-Talk, the ketogenic diet wasn’t on the list of the top-10 most Googled diets of 2015. Today, however, Dawn points that ketogenic diet is number one on the list. She asks Dom if he foresaw sudden mass interest in a ketogenic diet coming. [00:04:12] Ken asks Dom for his thoughts on how the ketogenic diet has went from being very obscure to becoming a household term. [00:06:04] Ken comments on the evolutionary component of the ketogenic diet and how our ancestors must have gone in and out of ketosis based on the availability of food. He also comments on the unique aspect of the ketogenic diet, being that it has an objective measurement, and asks Dom to talk about that. [00:06:59] Dawn comments on the cynicism regarding the ketogenic diet, particularly from nutritionists. She asks Dom to address the criticism and pushback that the ketogenic diet receives from so many nutritionists. [00:10:02] Ken mentions that some fields are resistant to change and new science due to the emotion behind established theories. Dom agrees and then talks about how people, even doctors, are resistant to new data and new science. [00:11:13] Dom talks about the most common misconceptions and overrepresentations of the ketogenic diet. [00:12:54] Ken discusses his dissatisfaction with the term “ketogenic diet” since the word diet implies the mandated consumption of certain food items. He goes on to say that if one is in ketosis, then, by definition, they are doing a ketogenic diet, even though they may be in ketosis because they have been fasting and haven’t eaten anything.  Ken and Dom discuss how knowledge about ketogenic nutrition has changed over time and that it is certainly possible to eat an unhealthy ketogenic diet. [00:15:35] Dom and Ken talk about the results of a recent Megan Roberts paper, “A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice,”that showed a 13% increase in the lifespan of the mice along with remarkably improved healthspan. [00:20:26] Dom shares his thoughts on the potential of exogenous ketones in the context of blood glucose regulation. [00:27:07] Ken asks if Dom has been tracking Virta Health, which was founded by Dr. Jeff Volek who was interviewed in STEM-Talk episode 43. Virta Health has been publishing impressive results of its trials that show  people reversing type-2 diabetes via a well-formulated ketogenic diet. [00:29:13] Ken adds that the reported numbers from Virta show 60% to 70% of their patients going off their insulin medication or greatly reducing their insulin levels. [00:30:55] Dawn asks about Dom’s experience going underwater for 10 days in participation of a NASA NEEMO mission. She asks him to talk about his personal experience as well as his background in hyperbaric physiology. [00:32:08] Dom discusses his group’s work replicating the experimental design of his original oxygen toxicity work in aged and obese rats. [00:33:35] Dawn briefly describes what oxygen toxicity is,

Todd has been a serial entrepreneur and creator since he was age 17. Today, after 15 years in the wine business his life is dedicated to educating and helping people make better choices about food, nutrition, and how they think about consuming alcohol. He is the founder of Dry Farm Wines; a writer, speaker, and a leading authority on healthy organic/natural wines and the importance of micro-dosing alcohol for health, longevity, and vitality. Todd’s passion is unlocking the best way to enjoy alcohol, how to enjoy the benefits of moderate consumption while avoiding the negative outcomes. Todd has been the featured guest on many of the Nation’s leading health influencer podcasts including Dave Asprey’s Bulletproof Radio, Mark Sisson’s Primal Blueprint, Ben Greenfield Fitness, Abel James’s Fat Burning Man, Robb Wolf ’s Paleo Solution, Drew Manning’s FIT2FAT2Fit, Jimmy Moore Livn Low Carb show, and Dr. Josh Handt’s Lifestyle Locker Radio. Dry Farm Wines is endorsed by many leading U.S. health influencers including Mark Sisson’s Primal Blueprint, Dave Asprey’s BulletProof Executive, Robb Wolf, Abel James, the Fat Burning Man, WellnessMama, Dr. Dom-inic D’Agostino, Dr. Ken Ford, Chris Kresser and best selling nutrition authors JJ Virgin, Dr. Mark Hyman and Dr. David Perlmutter.. Dry Farm Wines is also the Official Wine for many of the leading U.S. health and performance conferences, including Paleofx, Dave Asprey’s BulletProof Conference, Peter Diamondis’s A360, Joe Polish’s Genius Network Conference, LOWCARBUSA, Baby Bathwater Institute, The Environmental Health Symposium, KetoKademy, Metabolic Health Summit and JJ Virgin’s Mindshare Summit. Dry Farm Wines are also friendly to Low Carb, Paleo, ketogenic and diabetic low sugar diets. Dry Farm Wines have no impact on blood glucose or ketone production. Dr. Dominic D’ Agostino, widely considered the most influential ketogenic research scientist in North America also endorses Dry Farm Wines. Jimmy Moore, the best selling author of Keto Clarity and a leading advocate for the ketogenic diet also endorses Dry Farm Wines. Dry Farm Wines is the only lab tested, all natural health quantified wine merchant in the world that bio-hacks wine; quantifying organic and natural farming practices, as well as low intervention natural winemaking practices. Dry Farm Wines curates all natural pure real wines from all over the world, working with small family farms that are committed to producing pure natural wines. Dry Farm Wines is also proud to be the largest natural wine merchant in the world, supporting small family organic farms all over the world. Todd is a self-described Biohacker who practices daily meditation, Wim Hof breathing, cold thermogenesis, a ketogenic diet, daily 22 hour intermittent fasting and he is a fitness enthusiast. He is also a frequent speaker on the topics including; ketogenic diet and lifestyle, meditation, company culture and business performance. Dry Farm Wines has grown over 675x in revenue since its 2015 founding making it one of the fastest growing private companies in the U.S., doing so without any debt or investors.   www.DryFarmWines.com/LifestyleLocker https://www.youtube.com/c/DryFarmWines https://twitter.com/dryfarmwines https://www.instagram.com/dryfarmwines/ --- www.LifestyleLocker.com/DryFarmWines www.instagram.com/drjoshhandt www.facebook.com/lifestylelocker www.twitter.com/drjoshhandt www.linkedin.com/drjoshhandt YOUTUBE iTunes- Lifestyle Locker Radio

Show Summary After listening to an episode of the Tim Ferris show Mark Davies was inspred to experiment with the Ketogenic diet. After a perios of time on the diet Mark's type 1 diabetes was very well controlled, in fact he says better than before. Mark soon felt uninspred by his food choices and after a little research he and his partner Avni found a US based keto subscription box service and wanted to bring this type of option to the UK. Mentioned in the Show Tim Ferris Show with Dominic D'Agostino (https://tim.blog/2015/11/03/dominic-dagostino/) Ketokrate (https://www.ketokrate.com) Pink Himalyan Salt (https://amzn.to/2xVJI2T) Ketone/Blood Glucose Meter (https://amzn.to/2xXDm3j) [Freestyle Libre] (https://www.freestylelibre.co.uk/libre/) Warm Wild Pili Nuts (https://www.raw-wild.co.uk/shop) Mikhaila Peterson (http://mikhailapeterson.com) Joe Rogan interview with Mikhaila Peterson (https://player.fm/series/the-joe-rogan-experience-142216/ep-1164-mikhaila-peterson) HG Walter (https://www.hgwalter.com) Connect with Mark Instagram (https://www.instagram.com/ketogeniusuk/) Website (https://www.ketogenius.co.uk) Connect with Me If you enjoy the show please leave a review on iTunes, I would love it! iTunes Review (https://itunes.apple.com/gb/podcast/building-a-better-body/id1192279512?mt=2) Send Listener Questions to: info@karenmcclintock.co.uk Support The Show (https://karenmcclintock.co.uk/support/) My Social Media Facebook (https://www.facebook.com/buildingabetterbodypodcast) Instagram (https://www.instagram.com/buildingabetterbodypodcast) Website (http://www.karenmcclintock.co.uk) HUNTER & GATHER Discount Code: karen20off MRS R'GANICS Discount Code: karen10off Hunter & Gather T's & C's (https://hunterandgatherfoods.com/bbb/) Hunter & Gather Store (https://hunterandgatherfoods.com/ourshop/) Mrs R'ganics Site (https://mrsrganics.com) Special Guest: Mark Davies.

Not just anyone is up for the task of experimenting with their physical abilities while in a state of ketosis for NASA and the Department of Defense. But that is exactly what Doctor Dominic D’Agostino does. His research ensures Navy Seals and other military personnel reach their peak performance and resiliency levels through exogenous ketone use. During Dr. Dom’s return visit on the podcast, he answers all the questions you have about a ketogenic diet, exogenous ketones and why you should attend the 2019 Metabolic Health Summit.   If you like the podcast subscribe & review it on iTunes | Stitcher.   Key Takeaways:   [4:42] Dr. Dom is exploring the use of multiple exogenous ketones formulations for the Dept. of Defense and NASA. [13:59] Discovering glucose and ketone connections. [21:29] Dr. Dom’s thoughts on a strict carnivore diet. [27:19] Is a keto diet safe for women? [30:56] How does a ketogenic diet affect cholesterol levels? [37:59] How long can a person safely follow a ketogenic diet? [43:43] The Metabolic Health Summit is where keto science is shared with the health and fitness community.   Sponsors: Complete Wellness Supplements — Shop for Drew’s Hand-formulated Powdered Greens, Krill Oil, Apple Cider Vinegar in Pill Form, and now Keto Boost with Cordyceps and Beet Root Powder Dry Farm Wines — Use this link for a bottle of wine for $.01 with any order   Mentioned in This Episode: Keto Nutrition Metabolic Health Summit Listen to Episode 160 - Changing Your Environment Can Change Your Life with Benjamin Hardy   Fit2Fat2Fit Watch this episode of Fit2Fat2Fit on Youtube Fit2Fat2Fit on A&E Fit2Fat2Fit on Facebook Fit2Fat2Fit Book Drew on Social Media: @fit2fat2fit Email Drew: Drew@fit2fat2fit.com

This interview features Dr. Dominic D'Agostino. Dom is a Professor at the University of South Florida and a NASA Aquanaut. His research in brain chemistry has served numerous applications, such as improving the resilience of warfighters exposed to extreme environments. In this episode, Dom shares many insights regarding health sciences. Keep in mind, this podcast does not constitute any form of medical advice. Consult your physician for medical guidance.

Dominic D'Agostino, Ph.D., delivers an informative overview of the potential positive impact of ketogenic diets for disease prevention and treatment. He discusses how many cancers such as endometrial cancer and pancreatic cancer are associated with hyperglycemia, which is a hallmark of type II diabetes.D'Agostino is a tenured professor at the University of South Florida. Working with students at the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, D'Agostino's primary focus is in the areas of neuroscience and neuropharmacology, medical biochemistry, and physiology.  As a research scientist at the Institute for Human and Machine Cognition, D'Agostino aggressively pursues his research in methods to optimize and maximize the health, safety, and resilience of soldiers in combat, as well as astronauts. As a laboratory scientist D'Agostino and his team develop and test various metabolic-based strategies for seizures, epilepsy, cancer, and select neurodegenerative diseases. His primary focus for over a decade has been centered upon the many potential anticonvulsant and neuroprotective mechanisms of a ketogenic diet as well as ketone metabolite supplementation. D'Agostino is an active member of the Undersea and Hyperbaric Medicine Society, Society of Neuroscience, Aerospace Medical Association, American Physiological Society, and the American Association of Cancer Research. He holds a Ph.D. and BS from the esteemed Robert Wood Johnson Medical School and Rutgers University, respectively. D'Agostino discusses his current and primary focus on brain cancer and how the ketogenic diet has historically been used to treat epilepsy, thus brain tumor patients experiencing seizures may see significant benefit from a dietary change to this low-carb, high-fat, protein-adequate diet. He talks about the Warburg effect, the phenomenon in which cancer cells produce extra energy via increased oxygen-dependent glycolysis that is then followed by lactic acid fermentation with a secretion of lactate. D'Agostino provides information on cell metabolism; the ATP molecule, which is the nucleotide specifically known in biochemistry as the ‘molecular currency' of cell to cell energy transfer; as well as mitochondria and the links between diet and some cancers. The nutrition and health Ph.D. outlines other important and relevant studies, such as the work of Valter Longo, the Italian-American biogerontologist and cell biologist who is known primarily for his study of the role fasting and nutrient response genes play in disease and cellular protection. Additionally, he discusses the protective effects of short-term dietary restrictions as well as fasting, and the potential importance of ketones for metabolic health. While weight loss is essentially a good side effect of a ketogenic diet, the metabolic benefits provide even more advantages, in addition to the healthy effect of losing weight. He discusses the beneficial impact of decreasing glucose availability to tumors and implementing dietary restrictions as part of a treatment plan for some cancers. The shift in brain metabolism from glucose to ketones can actually reduce neuronal hyperexcitability and oxidative stress, which can enhance brain energy metabolism. D'Agostino feels this methodology can be used to treat a vast array of pathologies, including cancer.   Additionally, D'Agostino presents an important analysis of the microbiome, which is the community of microorganisms such as fungi, bacteria, and viruses that inhabit a specific environment, especially in regard to microorganisms living within or on the human body. He provides his opinion on the variations in microbiomes and how the optimal microbiome can differ based upon food eaten, geographical location, and other factors, and how a ketogenic diet and periodic fasting can help purge the overgrowth of the microbiome, and help return the body to balance. And D'Agostino discusses the glucose-ketone index, and how individuals seeking a healthier dietary balance and increased energy can monitor their index to ensure they are reaching ketosis with regularity for maximum health benefits.

I was lucky enough to interview Professor Thomas Seyfried for almost 2 hours, but I cut it down to 24 minutes to directly introduce the concept and their approach. He and others like Dominic D'Agostino are leading the way in researching and finding ways to heal cancer with metabolic therapies to fix the disease at its root cause in the mitochondria. This is much different than the typical assault on the body with chemo. MORE INFO If you are searching for more info on the topic for yourself or a family member, I highly recommend these 2 books: Tripping over the Truth - https://amzn.to/2NvTlLP Keto for Cancer - https://amzn.to/2KXJsF1 If you are a science nerd and interested in more details, be sure to read their research or read his textbook: Cancer as a Metabolic Disease - https://amzn.to/2tYFGoy DONATE Since money doesn't exactly flow towards researching an approach that cannot make a company or someone money, there is little funding for the metabolic theory of cancer research. If you would like to help or contribute to their research, here is a link to The Foundation for Metabolic Cancer Research. https://www.foundationformetaboliccancertherapies.com/  

Did you know that conventional wines can contain up to 76 additives that are NOT required to be listed on the label?! Want to know more about what toxic ingredients might be hiding in your wine? Curious how you can know if your wine is safe and what we recommend for wine consumption? Tune in to hear Ali and Becki interview Todd White, founder of Dry Farm Wines on how he got started in the natural wine business and how his company is looking to change the way we drink wine!   In this episode, Ali and Becki interview Todd on the scary and shady stuff that is going on in the wine industry and how his company is different. Wine has been consumed for 8,000 plus years and can be part of a balanced diet and lifestyle, but unfortunately the commercial wine industry has taken a turn for the worst with no regulation on labeling of wine and hidden colorants, pesticide residue and excessive sugar in most wines on the market. Todd is a wealth of knowledge on all things wine, from irrigation to fermentation to the many benefits of wine consumption. Learn about the extensive testing process Dry Farm Wines goes through to select only the top quality and safest wines to bring to consumers, emerging trends in the industry and his take on food and wine pairings!   Also in this episode: The Dry Farm Wines Story & Todd’s Background The Dirty Truth on Wine Additives Irrigation Fermentation How Wine Becomes Sugar Free Benefits of Wine Consumption Food Pairings Trends in the Wine Industry   Get a bottle for a penny with your first order using this link: dryfarmwines.com/alimillerRD   More about Todd White: Todd has been serial entrepreneur and creator since he was age 17.   Today, after 15 years in the wine business his life is dedicated to educating and helping people make better choices about food, nutrition, and how they think about consuming alcohol. He is the founder of Dry Farm Wines; a writer, speaker, and a leading authority on healthy organic/natural wines and the importance of micro-dosing alcohol for health, longevity, and vitality. Todd’s passion is unlocking the best way to enjoy alcohol, how to enjoy the benefits of moderate consumption while avoiding the negative outcomes. Todd has been the featured guest on many of the Nation’s leading health influencer podcasts including Dave Asprey’s Bulletproof Radio, Mark Sisson’s Primal Blueprint, Abel James’s Fat Burning Man, Robb Wolf’s Paleo Solution, Drew Manning’s FIT2FAT2FIT and Jimmy Moore Livn Low Carb show.   Dry Farm Wines is endorsed by many leading U.S. health influencers including Mark Sisson’s Primal Blueprint, Dave Asprey’s BulletProof Executive, Robb Wolf, Abel James, the Fat Burning Man, WellnessMama, Dr. Dominic D’Agostino, Dr. Ken Ford, Chris Kresser and best selling nutrition authors JJ Virgin, Dr. Mark Hyman and Dr. David Perlmutter.. Dry Farm Wines is also the Official Wine for many of the leading U.S. health and performance conferences, including Paleofx, Dave Asprey’s BulletProof Conference, Peter Diamondis’s A360, Joe Polish’s Genius Network Conference, LOWCARBUSA, Baby Bathwater Institute, The Environmental Health Symposium, KetoKademy, Metabolic Health Summit and JJ Virgin’s Mindshare Summit.   Dry Farm Wines are also friendly to Low Carb, Paleo, ketogenic and diabetic low sugar diets. Dry Farm Wines have no impact on blood glucose or ketone production.  Dr. Dominic D’ Agostino, widely considered the most influential ketogenic research scientist in North America also endorses Dry Farm Wines. Jimmy Moore, the best selling author of Keto Clarity and a leading advocate for the ketogenic diet also endorses Dry Farm Wines.   Dry Farm Wines is the only lab tested, all natural  health quantified wine merchant in the world that bio-hacks wine; quantifying organic and natural farming practices, as well as low intervention natural winemaking practices. Dry Farm Wines curates all natural pure real  wines from all over the world, working with small family farms that are committed to producing pure natural wines. Dry Farm Wines is also proud to be the largest natural wine merchant in the world, supporting small family organic farms all over the world.   Todd is a self described Biohacker who practices daily meditation, Wim Hof breathing, cold thermogenesis, a ketogenic diet, intermittent fasting and he is a fitness enthusiast. He is also a frequent speaker on the topics including; ketogenic diet and lifestyle, meditation, company culture and business performance. Dry Farm Wines has grown over 675x in revenue since its 2015 founding making it one of the fastest growing private companies in the U.S., doing so without any debt or investors.  

What are Exogenous Ketones? In this episode Dr. Dominic D’Agostino discusses this very hot topic. Are Exogenous Ketones Safe? What does the research say? What are the pros and cons of taking Exogenous Ketones? Are all products equal?  Dr. Dom answers all of these questions and more. If you have not listened to the first interview with Dr. Dom all about what Ketosis is, please go back and listen to that episode first. Episode 314.  Stop dieting & start living: www.131Method.com   Get the 131 Book!!!   Here’s The System I Use Every Day to be More Organized & Crazy Productive: www.pushjournal.com   Sign Up For MY WEEKLY NEWSLETTER and you'll get FREE tips on how to live a ridiculously amazing fun-filled life!   Be sure you are subscribed to this podcast to automatically receive your episodes!!!  Spotify Itunes  Stitcher    Subscribe to Build Your Tribe!!! Spotify  Itunes Stitcher      Join our NEW, awesome PodSquad on Facebook here!   Get episode show notes here: www.chalenejohnson.com/podcast    Connect with me on your fav social platform: SnapChat: ChaleneOfficial    Facebook: www.Facebook.com/Chalene      Instagram: www.Instagram.com/ChaleneJohnson    Twitter: www.Twitter.com/ChaleneJohnson   Hey! Send me a tweet & tell me what you think about the show! (Use the Hashtag) #TheChaleneShow so I know you’re a homie! XOXO Chalene

Scientist, researcher, neurobiologist, and ketogenic diet expert discusses the ketogenic diet and it's implications for physique athletes.

Dominic D'Agostino, PhD, is an associate professor at the University of South Florida's Morsani College of Medicine, as well as the Department of Molecular Pharmacology and Physiology. D'Agostino's focus of teaching is quite diverse as he educates in the areas of physiology, neuropharmacology, biochemistry (medical), cell metabolism, and signaling. D'Agostino's laboratory tests metabolic-based strategies for battling multiple human health problems such as seizures, epilepsy, neurodegenerative diseases, and more. The associate professor leads a discussion on various metabolic therapies including ketogenic diets, and the benefits of ketone supplements. Remarkably, one's level of ketosis can be assessed and measured in blood and urine samples. Ketosis is a metabolic state; essentially, when an individual removes carbohydrates from their diet they in turn force their body to deplete its stores of glycogen and seek out a new fuel source. As this takes place, ketosis is initiated when the body begins converting fat into ketones as its new, powerful fuel. While the shift may be a major adjustment for the body, and for individuals attempting to make the push toward a ketogenic diet, the results are obvious for most, with many people reporting a general feeling of well-being with more energy also. As D'Agostino explains, those who suffer from age-related cognitive decline, inflammation, or weight problems, all stand to benefit greatly from the shift to a ketogenic diet and the stimulation of ketosis. The physiology and cell metabolism professor explains how exogenous ketone supplementation can enhance the metabolic efficiency of the body, which can increase cognition and workflow activity. While many seek to get fully into a state of ketosis, this may not be the ultimate goal, for the goal is simply to feel better, and approximating the state may offer some benefits. Many are aware that ketosis can help with weight loss and appetite control, but as health seekers come for the weight loss they will more than likely also benefit from an advanced mental focus, more energy, and increased levels of HDL cholesterol. Additionally, ketosis can help to lower blood pressure and aid in the fight against type II diabetes. D'Agostino digs deep into the scientific workings behind variations on ketone supplementation. He discusses MCTs, or medium-chain triglycerides, and ketone salt combinations that can be delivered before low carbohydrate meals that can buffer the rise in glucose. The professor explains how the ketone benefit works within the body for suppression of appetite and increased cognitive function, and further, he relates how individuals can see improvements across the line with exogenous ketones even without adhering to an absolute ketogenic diet. D'Agostino provides some insight into ketone salts and ketone esters and their affect on the osmotic load in the gut. Ultimately, as D'Agostino explains, the scientific study of ketones is proving that many health issues can be improved by controlling the diet.

Have you been hearing a lot about the ketogenic diet and ketosis and wondering what it’s all about? What is ketosis and why is it that in the last 4-5 years, and especially lately, we’re hearing more and more about it? One of the leading researchers on ketones, Dr. Dominic D’Agostino, discusses the history and science behind ketones and the ketogenic diet. How do ketones impact neurological health and hormones, and should someone live in ketosis indefinitely? Stop dieting & start living: www.131Method.com   Get the 131 Book!!!   Here’s The System I Use Every Day to be More Organized & Crazy Productive: www.pushjournal.com   Sign Up For MY WEEKLY NEWSLETTER and you'll get FREE tips on how to live a ridiculously amazing fun-filled life!   Be sure you are subscribed to this podcast to automatically receive your episodes!!!  Spotify Itunes  Stitcher    Subscribe to Build Your Tribe!!! Spotify  Itunes Stitcher      Join our NEW, awesome PodSquad on Facebook here!   Get episode show notes here: www.chalenejohnson.com/podcast    Connect with me on your fav social platform: SnapChat: ChaleneOfficial    Facebook: www.Facebook.com/Chalene      Instagram: www.Instagram.com/ChaleneJohnson    Twitter: www.Twitter.com/ChaleneJohnson   Hey! Send me a tweet & tell me what you think about the show! (Use the Hashtag) #TheChaleneShow so I know you’re a homie! XOXO Chalene

Dr. Dominic D’Agostino, an assistant professor in molecular pharmacology and physiology joins me to discuss an approach he has developed to metabolically starving cancer cells through diet and compressed oxygen. We talked about breathing, the ketogenic diet and how we can fuel our bodies to prevent disease. You can also watch this episode at www.DrRonEhrlich.com. ----- WANT TO TAKE CONTROL OF YOUR HEALTH? Join me in my online health programs. ----- CONNECT WITH ME You can ask questions via social media using my Instagram or Facebook or YouTube page.