Podcasts about American Physiological Society

In this episode of Run with Fitpage, we have Dr. Stavros Kavouras, a distinguished Professor of Nutrition and Assistant Dean of graduate education at Arizona State University's College of Health Solutions. Professor Kavouras discusses the depths of hydration science and its impact on performance, with our host Vikas Singh.Dr Stavros is at the forefront of hydration science. As the visionary founder of the Hydration Science Lab, his pioneering research delves into the profound impact of water intake on both health and performance. Renowned globally, Dr. Kavouras ranks among the top 2% of the world's most cited scientists. With over 160 peer-reviewed articles to his credit, his work has been cited over 10,400 times, showcasing an impressive h-index of 54. A sought-after authority, he has shared his expertise through lectures spanning 29 countries.Dr. Kavouras' current research encompasses crucial areas such as hydration and glucose regulation, fluid composition for optimal hydration, and the intricate relationship between children's hydration and obesity. His editorial leadership is evident as Editor-in-chief of the Hydration section for Nutrients, a section editor of the European Journal of Nutrition, and an associate editor of Frontiers in Nutrition. Recognized for his contributions, Dr. Kavouras holds fellowships in esteemed institutions such as the American College of Sports Medicine and the European College of Sports Science. He is an elected member of prominent organizations including the American Society of Nutrition, the Obesity Society, and the American Physiological Society.Follow Dr Kavouras on,Twitter(X): @DrHydrationInstagram: @drhydrationLinkedIn: www.linkedin.com/in/stavros-kavouras-52032096/About Vikas Singh:Vikas Singh, an MBA from Chicago Booth, worked at Goldman Sachs, Morgan Stanley, APGlobale, and Reliance before coming up with the idea of democratizing fitness knowledge and helping beginners get on a fitness journey. Vikas is an avid long-distance runner, building fitpage to help people learn, train, and move better.For more information on Vikas, or to leave any feedback and requests, you can reach out to him via the channels below:Instagram: @vikas_singhhLinkedIn: Vikas SinghTwitter: @vikashsingh101Subscribe To Our Newsletter For Weekly Nuggets of Knowledge!

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours This week on the podcast, Mikki speaks to Dr Paul Reynolds about the effects of vaping on health, particularly its impact on inflammation, cancer risk, and pregnancy outcomes. Dr Reynolds, whose background is in lung development and disease, has been investigating how e-cigarettes influence inflammatory pathways, glycation, and long-term health risks.In this conversation, they discuss why breathing is more than just taking in oxygen and how air quality plays a critical role in overall health. Dr Reynolds explains glycation—how it damages the body—and how inflammation, often seen as a necessary defence mechanism, can sometimes do more harm than good.Mikki and Dr Reynolds delve into the chemicals found in e-cigarettes, comparing their inflammatory effects to traditional cigarettes. They explore whether vaping genuinely helps smokers quit or if it fosters new dependencies, as well as the risks of secondhand exposure and how vaping should be approached from a public health perspective.Dr Reynolds shares findings from his research on vaping during pregnancy, including its effects on foetal and placental weight, and the potential implications for conditions like intrauterine growth restriction (IUGR) and preeclampsia. They also discuss how e-cigarette flavours—such as Red Hot and Green Apple—can influence cancer cell invasion and inflammation, raising questions about whether some flavouring compounds should be restricted.With vaping still largely unregulated in many areas, Dr Reynolds offers insights into where research should focus next, what policymakers need to consider, and whether vaping should be treated with the same caution as smoking.This is a must-listen for anyone interested in the science behind vaping and its potential long-term health consequences. Enjoy the conversation!Dr Paul Reynolds is a professor in the Department of Cell Biology and Physiology at Brigham Young University, with a research focus on lung development, pulmonary disease, and the effects of environmental exposures such as tobacco and vaping aerosols on respiratory health. He holds a PhD in Developmental and Molecular Biology from the University of Cincinnati and has conducted extensive research on pulmonary injury, oxidative stress, and inflammatory pathways. His work examines how vaping impacts lung function, foetal development, and cancer progression, with recent studies exploring the role of e-cigarette flavours and nicotine in inflammation and disease risk. Dr Reynolds has received multiple awards for his research and teaching, including the Parker B. Francis Fellowship in Pulmonary Research, and is an active member of organisations such as the American Physiological Society and the American Thoracic Society.Dr Paul https://cell.byu.edu/directory/paul-reynolds Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

Dr. Jeremy Loenneke received his Ph.D. in Exercise Physiology from the University of Oklahoma, where he was mentored by Dr. Michael Bemben. Dr. Loenneke previously received his Master's degree in Nutrition and Exercise Science from Southeast Missouri State University, where he was mentored by Dr. Joe Pujol. Dr. Loenneke is a member of the American Physiological Society and the American College of Sports Medicine. He also serves on the editorial boards of many publications, including Sports Medicine, AGE, Medicine and Science in Sports and Exercise, and the Journal of Applied Physiology. Dr. Loenneke's study focuses on the adaptations of skeletal muscles to exercise in the presence of blood flow limitations. His latest study has provided answers to numerous critical methodological and safety problems about the use of blood flow restriction. Loenneke is the director of the Laboratory of Applied Physiology Kevser Ermin and his research group focuses on skeletal muscle adaptations to exercise with and without blood flow restriction. He is a member of the American Physiological Society and a Fellow of the American College of Sports Medicine. Work with RAPID Health Optimization Links: Jeremy P Loenneke on Instagram Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram

Send us a textDr. James L. Madara, MD, is CEO and Executive Vice President of the American Medical Association ( https://www.ama-assn.org/about/authors-news-leadership-viewpoints/james-l-madara-md ), the United States' largest physician organization. He also holds the academic title of adjunct professor of pathology at Northwestern University ( https://www.pathology.northwestern.edu/Faculty/profile.html?xid=24099 ).Since taking the reins of the AMA in 2011, Dr. Madara has helped sculpt the organization's visionary long-term strategic plan. He also serves as Chairman of Health2047 Inc. ( https://health2047.com/ ), the wholly-owned innovation subsidiary of the AMA, created to overcome systemic dysfunction in U.S. health care and located in Silicon Valley. Working closely with the AMA, Health2047 finds, forms and scales transformative health care spinout companies in four fields: chronic care, data utility, radical productivity and health care value. Several companies have been launched to date.Prior to the AMA, Dr. Madara spent the first 22 years of his career at Harvard Medical School, receiving both clinical and research training, serving as a tenured professor, and as director of the NIH-sponsored Harvard Digestive Diseases Center. Following five years as chair of pathology and laboratory medicine at Emory University, Dr. Madara served as dean of both biology and medicine, and then as CEO of the University of Chicago Medical Center, bringing together the university's biomedical research, teaching and clinical activities. While there he oversaw the renewal of the institution's biomedical campus and engineered significant new affiliations with community hospitals, teaching hospital systems, community clinics and national research organizations.Dr. Madara also served as senior advisor with Leavitt Partners, an innovative health care consulting and private-equity firm founded by former Health and Human Services Secretary Mike Leavitt.Having published more than 200 original papers and chapters, Dr. Madara has served as editor-in-chief of the American Journal of Pathology and as president of the American Board of Pathology.In addition to Modern Healthcare consistently naming him as one of the nation's 50 most influential physician executives, as well as one of the nation's 100 most influential people in health care, Dr. Madara has been recognized with several national and international awards. These include the prestigious MERIT Award from the National Institutes of Health, the Davenport Award for lifetime achievement in gastrointestinal disease from the American Physiological Society, and the Mentoring Award for lifetime achievement from the American Gastroenterological Society.Dr. Madara is an elected member of both the American Society of Clinical Investigation and the Association of American Physicians. He also co-chairs the Value Incentives & Systems Action Collaborative of the National Academy of Medicine (NAM), and is a member of NAM's Leadership Consortium for Value & Science-Driven Health Care.#JamesMadara #AmericanMedicalAssociation #AMA #Physicians #Pathology #IntestinalEpithelialPathobiology #MedicalSchool #MedicalEducation #HealthEquity #UniversityOfChicago #SocialDeterminantsOfHealth  #NorthwesternUniversity #Health2047 #VentureCapital #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

On this week's episode of the Escape Your Limits podcast, we are joined by Dr. Jim Stoppani, a renowned expert in exercise science, sports nutrition, and supplementation, with over 15 years of experience helping millions transform their lives through science-backed training and nutrition plans. He earned his PhD in exercise physiology and a minor in biochemistry from the University of Connecticut and completed postdoctoral research at Yale University, focusing on exercise and gene regulation in muscle tissue. He was presented with the Gatorade Beginning Investigator Award by the American Physiological Society for his research. After serving as Senior Science Editor for Weider Publications, he launched JYM Supplement Science in 2013, a pioneering sports nutrition company and has authored influential books, including The Encyclopedia of Muscle & Strength and LL Cool J's Platinum 360 Diet and Lifestyle. In this podcast, Dr. Jim Stoppani discusses: New research into muscle growth. Mathematical models for maximizing muscle. Strategies for the fit vs. more unfit exerciser. Weight loss, muscle gain and lifestyle change. Optimal workouts for fat loss vs. muscle gain. Testosterone, supplements and the anabolic window. Full body vs Split body workouts. Time under tension and its role in muscle building. Muscle protein synthesis. The benefits of intermittent fasting. Creatine and protein intake guidelines. How alcohol impacts sleep, muscle gain and recovery. To learn more about Dr. Jim Stoppanni, click here: https://www.jimstoppani.com/ https://jymsupplementscience.com/ ====================================================== Subscribe to our YouTube channel and turn on your notifications so you never miss a new video when it's published: https://www.youtube.com/user/EscapeFitness Shop gym equipment: https://escapefitness.com/shop View our full catalog: https://escapefitness.com/support/catalog (US) https://escapefitness.com/support/catalogue (UK)  ====================================================== Facebook: https://www.facebook.com/Escapefitness Instagram: https://www.instagram.com/escapefitness Twitter: https://www.twitter.com/escapefitness LinkedIn: https://www.linkedin.com/company/escapefitness/   0:00       Intro 0:20       New research into muscle growth 3:09       Range of motion and muscle growth 5:57       Stretching and muscle growth 6:58       Applying new research to workouts 12:49    Importance of time under tension 14:44    Scientific models and muscle growth 21:23    The ideal amount of muscle for health 26:57    Protein intake and essential amino acids 46:23    The benefits of creatine for performance 54:15    Balancing lifestyle changes 15:18    Full body vs. split body workouts 1:04:01 Exercises that trigger testosterone

Can you Build Muscle without Heavy Lifting? Join Dr. Gabrielle Lyon as she sits down with Dr. Jeremey Loenneke, an associate professor of exercise science at the University of Mississippi and one of the world's leading experts in blood flow restriction (BFR) training. They discuss the science behind skeletal muscle adaptation, how BFR can help you get stronger without heavy weights, and why muscle growth and strength aren't always the same thing.Dr. Loenneke shares insights on how BFR works—using low loads to trigger muscle adaptation and growth—and the potential benefits for recovery, rehabilitation, and even everyday training for those wanting to avoid joint strain. They also explore some fascinating phenomena like cross-education, where training one side of your body can strengthen the other side.Key Highlights:The basics and benefits of blood flow restriction trainingHow to build muscle with low weight loadsThe difference between muscle growth and muscle strengthPractical applications of BFR in both sports and rehabilitationDon't miss out on these expert insights that can transform your approach to exercise and recovery. Let's take your fitness knowledge to the next level!Who is Dr. Jeremey Loenneke?Dr. Jeremy Loenneke is an Associate Professor of Exercise Science at The University of Mississippi within the School of Applied Sciences. He received his MS in Nutrition and Exercise Science from Southeast Missouri State University and his PhD in Exercise Physiology from the University of Oklahoma. He is the director of the Kevser Ermin Applied Physiology Laboratory and his research group's primary focus is on skeletal muscle adaptations to exercise with and without the application of blood flow restriction. His recent work has also focused on addressing whether or not muscle growth contributes to changes in strength with exercise. Dr. Loenneke is a Fellow of the American College of Sports Medicine and a member of the American Physiological Society. He has authored numerous peer-reviewed articles and is an Associate Editor for PLOS One, Peer J, and Research Quarterly for Exercise and Sport. He also serves on the editorial board for Sports Medicine and Medicine and Science in Sports and ExerciseJoin my all new 6 Week Forever Strong Bootcamp - https://bit.ly/3ZwQda7 Apply to become a patient - https://drgabriellelyon.com/new-patient-inquiry/ Join my weekly newsletter - https://institute-for-muscle-centric-medicine.ck.page/2ed23e2860 Get my book - https://drgabriellelyon.com/forever-strong/This episode is brought to you by :Zocdoc - Book your First Appointment! - https://zocdoc.com/DRLYONMUD/WTR - Code DRLYON for $20 OFF - https://mudwtr.com/drlyonPaleovalley - Code DRLYON for 15% OFF First Order! - http://paleovalley.com/DRLYONNeeded - Code DRLYON for 20% OFF - https://thisisneeded.com/DRLYONFatty15 - Code DRLYON for 15% OFF - https://fatty15.com/DRLYONFind me at:Instagram: @drgabriellelyonTik Tok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube:...

In this episode of Run with Fitpage, we have with us Dr Scott Trappe, who is one of the leading researchers in the field of exercise science. Dr Scott discusses the correct way of tapering for runners and alot more, with our host, Vikas Singh. Dr. Scott Trappe is a renowned expert in human bioenergetics and muscle physiology, currently serving as the John and Janice Fisher Endowed Professor of Human Bioenergetics and the Director of the Human Performance Laboratory at Ball State University in Muncie, IN. With over 25 years of experience, Dr. Trappe has made significant contributions to the fields of exercise science, aging, and space medicine. He earned his undergraduate degree at the University of Northern Iowa, where he was also the captain of the swim team. He completed his graduate studies (MS) at the University of Colorado while working with US Swimming at the Olympic Training Center in Colorado Springs. He received his PhD from Ball State University, studying under the esteemed Dr. David Costill, and completed post-doctoral training in muscle physiology with Dr. Robert Fitts at Marquette University. For over two decades, Dr. Trappe has collaborated with NASA to optimize exercise protocols for astronauts, ensuring their health and performance during space missions. His research has been instrumental in understanding muscle plasticity and the powerful effects of exercise on human health.Dr. Trappe has led numerous NIH-funded studies on exercise training in older adults, aging athletes, and elite athletes. He is a principal investigator for one of the human clinical centers in MoTrPAC, a nationwide consortium studying the health benefits of exercise through a comprehensive whole-body to gene approach.Throughout his career, Dr. Trappe has mentored many post-doctoral, doctoral, and master's students, contributing to the next generation of scientists in exercise physiology. He is a Fellow of the American College of Sports Medicine (ACSM) and a member of the American Physiological Society and the American Association for the Advancement of Science.For more on Dr. Scott Trappe's research and publications, visit his PubMed profile.About Vikas Singh:Vikas Singh, an MBA from Chicago Booth, worked at Goldman Sachs, Morgan Stanley, APGlobale, and Reliance before coming up with the idea of democratizing fitness knowledge and helping beginners get on a fitness journey. Vikas is an avid long-distance runner, building fitpage to help people learn, train, and move better.For more information on Vikas, or to leave any feedback and requests, you can reach out to him via the channels below:Instagram: @vikas_singhhLinkedIn: Vikas SinghTwitter: @vikashsingh101Subscribe To Our Newsletter For Weekly Nuggets of Knowledge!

Dr Heinrich Nolte graduated with an MBBCh from the University of the Witwatersrand. He received his. doctorate in Exercise Physiology from the University of Pretoria. In addition, Dr Nolte received an MA (HMS) specialising in Biokinetics (Cum Laude) and his BA (HMS) Honours, specialising in Biokinetics from the University of Pretoria. Afterwards, he completed postgraduate courses in Musculoskeletal Ultrasound, Advanced Cardiac Life Support and Advanced Clinical Care in HIV management, to name a few.Dr. Nolte is registered with the Health Professions Council of South Africa (HPCSA) as a Medical Practitioner and Biokineticist. He is a Honorary Researcher at the Movement Physiology Research Laboratory of the School of Physiology, Faculty of Health Sciences, University of the Witwatersrand and is a laboratory member of the Human Potential Translational Research Programme of the Yong Loo Lin School of Medicine at the National University of Singapore. Furthermore, Dr Nolte is a member of the American Physiological Society.Dr. Nolte is an international member of the American Academy of Physical Medicine and Rehabilitation (AAPM&R), a medical speciality organisation representing physicians who specialise in Physical Medicine and Rehabilitation. Dr Nolte has published numerous scientific research papers in international academic journals and presented papers at various international academic conferences.

In our latest episode, Physiological Reviews Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews authors Dr. Leigh Peterson (Executive Vice President for Product Development and Xenotransplantation at United Therapeutics Corporation) and Professor Sir Magdi Yacoub (Professor of Cardiothoracic Surgery at the National Heart and Lung Institute at Imperial College London, and Founder and Director of Research at the Harefield Heart Science Centre and Aswan Heart Centre). The authors have published a comprehensive review on xenotransplantation. Listen as they discuss the steps necessary to immunologically modify pigs to avoid acute rejection and minimize chronic rejection, as well as the main differences between the GalSafe and the 10GE pigs described in the article. Given that the American Physiological Society launched their Women's Health Research Initiative in spring 2024, we discuss how xenotransplantation and women's health research are connected. What are the next important developments in this field? Listen to find out more.   Leigh Peterson, Magdi Yacoub, David Ayares, Kazuhiko Yamada ,Daniel Eisenson, Bartley P. Griffith, Muhammad Mohiuddin, Will Eyestone, J. Craig Venter, Ryszard T. Smolenski, and Martine Rothblatt Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review Physiological Reviews, published June 7, 2024. DOI: 10.1152/physrev.00041.2023

JIM STOPPANI, PhD, is the leading authority on exercise science, sports nutrition, and supplementation. Over the past 15+ years, Dr. Stoppani has helped millions of people change their lives through science-based nutrition and supplement plans and expertly designed training programs. He received his doctorate in exercise physiology with a minor in biochemistry from the University of Connecticut. Following graduation, he served as a postdoctoral research fellow in the prestigious John B. Pierce Laboratory and Department of Cellular and Molecular Physiology at Yale University School of Medicine, where he investigated the effects of exercise and diet on gene regulation in muscle tissue. In 2002, Dr. Stoppani was awarded the Gatorade Beginning Investigator in Exercise Science Award by the American Physiological Society for his groundbreaking research. After his Yale stint, Dr. Stoppani was on the editorial staff at Weider Publications for 11 years, serving as Senior Science Editor for Muscle & Fitness, FLEX and Muscle & Fitness Hers magazines. In 2013, he left Weider to create the ground-breaking sports nutrition company JYM Supplement Science. Dr. Stoppani has authored or co-authored several books, including the Encyclopedia of Muscle & Strength (Human Kinetics, 2006); the New York Times Bestseller LL Cool J's Platinum 360 Diet and Lifestyle (Rodale, 2010); and Stronger Arms & Upper Body (Human Kinetics, 2008). Dr. Stoppani has also been the personal nutrition and health consultant for numerous celebrity clients, including LL Cool J, Dr. Dre, Dwayne “The Rock” Johnson, and Mario Lopez. Through his various platforms – from print magazines and books to online as a featured expert on Bodybuilding.com and the owner of JimStoppani.com – Dr. Stoppani has become one of the most trusted, reliable sources of fitness information on the Internet. The JYMARMY Facebook group page – a community of passionate individuals who follow his training, nutrition and supplement plans – is one of the largest and most engaging online groups, with over 60,000 members. His personal and company mission is to change lives through proper training, nutrition and supplementation, all based on the latest scientific research, while following the motto of “Do the Right Thing.” WWW.JIMSTOPPANI.COM  

In this episode of Run with Fitpage, we have Dr. Stavros Kavouras, a distinguished Professor of Nutrition and Assistant Dean of graduate education at Arizona State University's College of Health Solutions. Professor Kavouras discusses the depths of hydration science and its impact on performance, with our host Vikas Singh.Dr Stavros is at the forefront of hydration science. As the visionary founder of the Hydration Science Lab, his pioneering research delves into the profound impact of water intake on both health and performance. Renowned globally, Dr. Kavouras ranks among the top 2% of the world's most cited scientists. With over 160 peer-reviewed articles to his credit, his work has been cited over 10,400 times, showcasing an impressive h-index of 54. A sought-after authority, he has shared his expertise through lectures spanning 29 countries. Dr. Kavouras' current research encompasses crucial areas such as hydration and glucose regulation, fluid composition for optimal hydration, and the intricate relationship between children's hydration and obesity. His editorial leadership is evident as Editor-in-chief of the Hydration section for Nutrients, a section editor of the European Journal of Nutrition, and an associate editor of Frontiers in Nutrition. Recognized for his contributions, Dr. Kavouras holds fellowships in esteemed institutions such as the American College of Sports Medicine and the European College of Sports Science. He is an elected member of prominent organizations including the American Society of Nutrition, the Obesity Society, and the American Physiological Society.Follow Dr Kavouras on,Twitter(X): @DrHydrationInstagram: @drhydrationLinkedIn: www.linkedin.com/in/stavros-kavouras-52032096/About Vikas Singh:Vikas Singh, an MBA from Chicago Booth, worked at Goldman Sachs, Morgan Stanley, APGlobale, and Reliance before coming up with the idea of democratizing fitness knowledge and helping beginners get on a fitness journey. Vikas is an avid long-distance runner, building fitpage to help people learn, train, and move better.For more information on Vikas, or to leave any feedback and requests, you can reach out to him via the channels below:Instagram: @vikas_singhhLinkedIn: Vikas SinghTwitter: @vikashsingh101Subscribe To Our Newsletter For Weekly Nuggets of Knowledge!

Today's guest is a leading authority on exercise science, sports nutrition, and supplementation with over 20 years of experience. He also leads by example and is in phenomenal shape at 56 years old. Dr. Jim Stoppani received his doctorate in exercise physiology with a minor in biochemistry from the University of Connecticut. Following graduation, he served as a postdoctoral research fellow in the prestigious John B. Pierce Laboratory and Department of Cellular and Molecular Physiology at Yale University School of Medicine, where he investigated the effects of exercise and diet on gene regulation in muscle tissue. In 2002, Dr. Stoppani was awarded the Gatorade Beginning Investigator in Exercise Science Award by the American Physiological Society for his groundbreaking research. After his Yale stint, Dr. Stoppani was on the editorial staff at Weider Publications for 11 years, serving as Senior Science Editor for Muscle & Fitness, FLEX and Muscle & Fitness Hers magazines. In 2013, he left Weider to create the ground-breaking sports nutrition company JYM Supplement Science. In this episode, we dive into Dr. Stoppani's joinery, his tips inside and outside of the gym, how the industry has changed over the past 20 years, and more!   Time Stamps:   (1:00) Dr. Stoppani Bio (2:45) Industry Changes Over the Past 20 Years (12:30) The Published Print Days (15:50) Bodybuilding Competition Days (20:05) Fasted Cardio Example (25:05) Low Carb vs Intermittent Fasting (36:20) Runner's Need Protein Too (46:10) Working With Clients (51:18) Your Workouts Aren't Enough (56:38) Where To Find Dr. Stoppani -------------------- Dr. Stoppani's Website: https://www.jimstoppani.com   Dr. Stoppani's Instagram: https://www.instagram.com/jimstoppani/   Dr. Stoppani's Youtube: www.youtube.com/@DrJimStoppani   Dr. Stoppani's X Account: https://twitter.com/JimStoppani   Jim Stoppani's Encyclopedia of Muscle and Strength: https://a.co/d/3fYnyxe -------------------- Instagram: https://www.instagram.com/carolcovinofitness/ -------------------- My YouTube Channel: http://youtube.com/@carolcovinofitness -------------------- Finding Purpose in the Pause Book: https://www.amazon.com/dp/B0BZQKKZC8

This episode's special guest is a legend in the fitness industry, the one and only Jim Stoppani! Dr. Jim Stoppani is a leading authority on exercise science, sport nutrition, and supplementation. He received his doctorate in exercise physiology with a minor in biochemistry from the University of Connecticut. After graduation, he served as a postdoctoral research fellow at Yale University School of Medicine, where he investigated the effects of exercise and diet on gene regulation in muscle tissue. For his research he was awarded the 2002 Gatorade Beginning Investigator in Exercise Science Award by the American Physiological Society. From 2002 to 2013 Stoppani was the senior science editor for Muscle & Fitness, Muscle & Fitness Hers, and Flex magazines. He went on to be a massive piece of bodybuilding.com's success in the early years of online fitness content. Finally, he is the owner of JYM Supplement Science – his personal company. Now, on top of all the educational accolades and credentials – Dr. Jim Stoppani has written thousands of articles on exercise, nutrition, and health for some of the largest production companies in the fitness industry. He is the coauthor of the best sellers LL Cool J's Platinum 360 Diet and Lifestyle, Stronger Arms & Upper Body, and PrayFit. He has even been the personal nutrition and health consultant for Dwayne "The Rock" Johnson, LL Cool J, Dr. Dre, Mario Lopez, and Chris Pine. So… in a nutshell… Jim has been around the block and done a thing or two, which is why today is a very special episode and one that provides a TON of value! You can follow Jim on IG at @jimstoppani or check out his site, https://www.jimstoppani.com/  —

Dr. Mike Sawka is Chief Scientific Officer at Environmental Physiology and Hydration Associates, an Adjunct Professor at Georgia Tech, and a Member of the PCC's Scientific Advisory Board and the Performance Hematology Working Group. He is also a Fellow of the American Physiological Society (APS). Today, we're excited to talk about Mike's career, his work with the PCC over the years, and his involvement with the American Physiological Society. He will also be discussing initiatives from the PCC and the APS designed to attract early-career and established researchers to the field of anti-doping, as well as some of the success stories to date.

Christine Yu is an award-winning journalist. She writes about sports, science, and health. She especially loves telling stories about the intersection of sports science and women athletes and wrote a book about it. UP TO SPEED: The Groundbreaking Science of Women Athletes, was published on May 16, 2023 by Riverhead Books, an imprint of Penguin Random House. Her reported features, profiles, and essays have appeared in The Washington Post, Outside Magazine, Runner's World, Family Circle, SELF, Eating Well, VICE, and espnW, among others. {See her portfolio here.} She also writes for trade publications, professional associations, educational institutions, and brands. Her clients include Columbia University, Johns Hopkins University, Phillips Academy, the American Physiological Society, and REI. In addition to writing, she's a seasoned grant writer and has led and managed the full cycle of program development for requests to private and corporate funders as well as local, state, and federal government agencies. She earned her B.A. in Art History from Columbia University and her Masters of Public Policy from the Harvard Kennedy School at Harvard University. She lives in Brooklyn, NY with my husband and two sons. She's a lifelong athlete who likes to run, practice yoga, hike, swim, and surf. Christine's Website/Book Artwork photo credit: Shelly Xu / @someshellyphotography Learn more about your ad choices. Visit megaphone.fm/adchoices

What does being a good ally look like? In a new Perspective, authors Dr. Karla Haack (Merck), Dr. Austin Robinson (Auburn University), Dr. Dexter Lee (Howard University College of Medicine), Dr. Keisa Mathis (University of North Texas Health Science Center), and Dr. Junie Paula Warrington (University of Mississippi Medical Center) discuss how the American Physiological Society (APS) can promote Black physiologists and support them in the challenges they face. The authors sat down with The AJP-Heart and Circ Podcast for a wide-ranging interview at the cross-section of social justice and science. The authors feel that APS has a unique opportunity as an international organization to be at the forefront of supporting Black physiologists and boosting the success of underrepresented minority APS members. As the authors note, Black students are often first-generation college students, and therefore mentoring and K-12 physiology outreach are critically important. Robinson et al. discuss issues around the underrepresentation of Black physiologists at the faculty level, as well as challenges with access to pilot funding to support Black early career researchers. The authors discuss many actionable steps, such as inviting Black physiologists to be scientific co-investigators and co-authors on studies, as well as partnering with Historically Black Colleges and Universities to help build a pipeline of future Black physiologists. The authors take-home message? Don't underestimate the power of being an ally and using your voice to amplify the voices of Black physiologists. As Dr. Junie Paula Warrington stated, “One person at a time, we can make a huge impact.”   Austin T. Robinson, Nathaniel D. M. Jenkins, Sofia O. Sanchez, Karla K. V. Haack, Dexter L. Lee, Keisa W. Mathis, and Junie P. Warrington Supporting and promoting Black physiologists: how can the APS help? Am J Physiol Heart Circ Physiol, published May 4, 2023. DOI: 10.1152/ajpheart.00082.2023

Show notes: [1:40] How did he get into studying Blood Flow Restriction? [3:58] What is BFR training? [6:39] How do you do BFR training? [10:59] What are the gold standard devices for BFR? [13:46] What are the benefits of BFR training? [19:00] Muscle strength and muscle strength [26:28] On workout frequency and how he works out [31:05] Maintaining mobility [39:11] Starting BFR training [45:09] Outro Who is Dr. Loenneke? Dr. Loenneke is the director of the Kevser Ermin Applied Physiology Laboratory and his research group's primary focus is on skeletal muscle adaptations to exercise with and without the application of blood flow restriction. He is a Fellow of the American College of Sports Medicine and a member of the American Physiological Society.   Learn more about Dr. Loenneke: Website: https://olemiss.edu/people/jploenne Twitter: https://twitter.com/jploenneke?lang=en IG: https://www.instagram.com/jploenneke/?hl=en Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram

Director of Sport Science at Ultimate Fighting ChampionshipA PHD IN PHYSIOLOGY WITH 20+ YEARS OF EXPERIENCE AND INNOVATION IN SPORTS SCIENCE, TECHNOLOGY AND PERFORMANCE.LEADERSHIP & MANAGEMENT• 20+ years experience in team leadership roles in sport science, technology, and professional sports.• Founder of Research Institute of Sports for Olympic-level athletes.• Launched 15 research labs and Mobile Labs for the national teams utilized in 4 Olympic Games.SPORT SCIENCE• Published 70+ original scientific articles, 2 books.• Member of the American Physiological Society, ACSM, ECSS, SfN.• Won 6 grants with a total sum of $ 21M.• Amassed 30+ professional certificates, and 4 awards.

Physiological Reviews Associate Editor Prof. Christoph Handschin speaks with Prof. Paul L. Greenhaff and Prof. Janet M. Lord about their article “Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity,” published in the April 2023 issue of Physiological Reviews. Prof. Greenhaff is Professor at the School of Life Sciences at the University of Nottingham and is deputy director of the Medical Research Council (MRC)-Versus Arthritis Centre for Musculoskeletal Ageing Research. Prof. Lord is Professor at the Institute of Inflammation and Ageing at the University of Birmingham and is the director of the MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research. Introduction of the authors [1:06] What does the term ‘frailty' actually mean, and how is it clinically defined? [2:49] Are there specific risk factors that increase the chance of becoming frail? [5:18] What interventions are useful to guard against frailty? [6:55] How important will mechanistic aspects of frailty be in our understanding and treatment of frailty? [13:55] Are there things we can do with regard to prevention, the mindset of patients and physicians, and interventions in the clinic? [21:10] What advice do the authors have to minimize the impact of frailty, regardless of age? [23:15] The importance of remaining mentally active [25:55]  Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available. Browse recent articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and Facebook. Listen to other podcasts produced by the American Physiological Society.

Blood Flow Restriction TrainingGuest: Dr. Jeremy LoennekeBio: Dr. Jeremy Loenneke credentials include a Master's degree in Nutrition and Exercise Science from Southeast Missouri State University, as well as a PhD in Exercise Physiology from the University of Oklahoma. Dr. Loenneke is the director of the Kevser Ermin Applied Physiology Laboratory and his research group's primary focus is on skeletal muscle adaptations to exercise with and without the application of blood flow restriction. He is a Fellow of the American College of Sports Medicine and a member of the American Physiological Society. He has also authored numerous peer-reviewed articles and currently serves on the editorial board for Sports Medicine, Medicine and Science in Sports and Exercise, PLOS One, Peer J, and Journal of Trainology.Links:@jploenneke on Twitter and Instagram

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Dr. Paule V. Joseph about her article “A Systematic Review of the Biological Mediators of Fat Taste and Smell,” the first systematic review to be published in Physiological Reviews. Dr. Joseph is Lasker Clinical Research Scholar, Tenure Track Clinical Investigator, and Chief of the Section of Sensory Science and Metabolism in the Division of Intramural Clinical and Biological Research at the National Institute of Alcohol Abuse and Alcoholism. She has a a joint appointment at the National Institute of Nursing Research. Dr. Joseph's research focuses on preclinical, clinical, and translational studies of chemosensory disorders. In August 2022, she was selected as the inaugural 2022–2024 American Academy of Nursing Fellow at the National Academy of Medicine. Dr. Joseph is a member of the Physiological Reviews Editorial Board. Introduction of Dr. Joseph [1:07] Author's background [2:40] Why did Dr. Joseph and her coauthors write a systematic review instead of a narrative review? [6:47] Discussion of the main receptors responsible for the sensations of taste and smell, and how their activation relates to obesity [10:12] How does SARS-CoV-2 result in loss of taste and smell, and why does it occur following a COVID infection and not with other respiratory viruses? [14:40] Are polymorphisms associated with obesity or, conversely, with very low body mass index (BMI)? [19:49] Do environmental factors play a role in the regulation of fat and smell receptors? [22:39] Suggestions for improving outreach within the nursing community [25:26] Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available. Browse recent articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and Facebook. Listen to other podcasts produced by the American Physiological Society.

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with    Prof. John P.A. Ioannidis about his editorial “Systematic Reviews for Basic Scientists: A Different Beast,” which focuses on the importance of systematic reviews in scientific research. Prof. Ioannidis is Professor of Medicine, of Epidemiology and Population Health, and, by courtesy, of Statistics and Biomedical Data Science at Stanford University. He is one of the most cited scientists in the world and is an elected member of numerous national academies. Prof. Ioannidis in an Associate Editor of Physiological Reviews. Introduction of Prof. Ioannidis [1:26] Author's background [3:08] Discussion of reproducibility in science [5:35] Discussion of sample size in research [7:31] What exactly is a systematic review, and how can it address bias? [10:41] Do systematic reviews have a place in basic research, or should they be used mostly in clinical science? [13:29] What is a “living review”? [15:35] What does the future hold for the format of review articles? [18:34] The importance of collaboration in science [21:50] Advice for early-career researchers [24:57] Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available. Browse recent articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and Facebook. Listen to other podcasts produced by the American Physiological Society.

Physiological Reviews Associate Editor Prof. Giovanni Mann speaks with Prof. Rafael Radi about his review article “The superoxide radical switch in the biology of nitric oxide and peroxynitrite,” about the life of a scientist, and about advice for early-career researchers. Prof. Radi is Professor, Chair, and Director of the Centro de Investigaciones Biomédicas (CEINBIO) at the Universidad de la República in Montevideo, Uruguay. Prof. Radi has made significant contributions to our understanding of the mechanisms of nitric oxide-dependent toxicity through its interaction with superoxide anions and the formation of peroxynitrite. He has characterized the biological chemistry of peroxynitrite, its effects on mitochondrial dysfunction and apoptosis, and its role in pathology. Introduction of Prof. Radi [0:45] Author's background [2:40] Advice to early-career investigators seeking to take on a career in research [10:07] Discussion of collaboration between professional organizations that facilitates sharing of research among early-career researchers from different countries [13:57] Insight into the sources of superoxide, and which in particular Prof. Radi believes contributes primarily to the role of superoxide acting as a ‘radical switch' [16:37] The importance of physiologically relevant oxygen levels in the interplay of nitric oxide, oxygen, and peroxynitrite during experiments [20:54] From a translational perspective, can this area of inquiry make any contributions to benefit patients? [25:13] Will basic and clinical scientists be able to target specific activators or inhibitors of nitric oxide synthase(s) or nitric oxide donors to individual organs or tissues? [29:07] Formation of peroxynitrite under lower oxygen levels [31:28] Advice for young people interested in pursuing basic science and/or medicine as a career [35:33] Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available. Browse recent articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and Facebook. Listen to other podcasts produced by the American Physiological Society.

The body's most potent vasoconstrictor? This season starts of on the topic endothelin, with an amazing interview with Professor David Pollock, former President of the American Physiological Society, from the University of Alabama at Birmingham.

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Prof. Rebecca M. Reynolds, Prof. Sarah J. Stock, and Prof. Hilary O. D. Critchley about their editorial “Pregnancy and the SARS-CoV-2 Pandemic,” published in the July 2022 issue of Physiological Reviews. The authors also have contributed a review article on this topic, “Pregnancy and COVID-19,” which was one of the most highly cited articles published in the journal in 2021. Prof. Reynolds is Professor of Metabolic Medicine at the University of Edinburgh. Her research looks at the ways in which early development in utero can affect health and disease. Prof. Stock is Professor of Maternal and Fetal Health at the University of Edinburgh. Her research examines efforts at reducing preterm birth, stillbirth, and other complications in pregnancy. Prof. Critchley has held a Personal Chair in Reproductive Medicine at the University of Edinburgh since 1999. She is Head of the Deanery of Clinical Sciences at the University of Edinburgh, she is Co-Director of the Medical Research Council Centre for Reproductive Health, and she is Consultant Gynaecologist at the Royal Infirmary in Edinburgh. Her research is aimed at improving our understanding of the basic science of the uterine endometrium. She is an Associate Editor of Physiological Reviews. Author introductions [0:41] Efficacy of vaccination in diminishing the severity and long-term consequences of COVID-19 [6:44] Does COVID-19 vaccination cause any significant side effects for the pregnant woman or the fetus? [8:08] Are women who are pregnant at higher risk for COVID infection, and can the virus cross the placenta? [15:53] Does SARS-CoV-2 affect the development of preeclampsia? [21:19] What kinds of treatments are available -- and safe -- for pregnant women with COVID? Are there any animal models in which interventions may be tested? [24:05] What other work is being conducted on this topic? [28:38] Discussion of the effects of SARS-CoV-2 infection or COVID vaccination on menstruation [31:27] Closing remarks [35:59] Subscribe to the podcast here. Browse recent articles on our website. Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and on Facebook. Listen to other podcasts produced by the American Physiological Society.

In this episode of Run with Fitpage, we invited the top researcher in the field of lactate metabolism, exercise metabolism, control of blood flow during exercise, and exercise fatigue — the director of Muscle Physiology Lab, Dr. Bruce Gladden. Dr. Gladden is a Distinguished Professor in the School of Kinesiology at Auburn University. He is the author or co-author of 100+ refereed research articles, book chapters, and reviews. He is known nationally and internationally for his research on the role of lactate in metabolism and activation of mitochondrial metabolism in skeletal muscle (oxygen uptake kinetics).Dr. Gladden received the American College of Sports Medicine's (ACSM) Citation Award in 2015, the American Physiological Society's (APS) Environmental and Exercise Physiology (EEP) Section's Honor Award for 2020, and he served two terms (2014-2022) as Editor-in-Chief of Medicine & Science in Sports & Exercise and continues now as a Consulting Editor. He is also an Associate Editor for ACSM's new open-access journal, Exercise, Sport & Movement. He is currently Immediate Past-President of ACSM, has served as Southeast ACSM President, and has been recognized as the Southeast ACSM Montoye Scholar, and SEACSM Service Awardee. He has also served as Chair of the EEP section of APS. He was presented the Auburn University Creative Research and Scholarship Award in 2020.This episode is ALL ABOUT LACTIC ACID. As the episode progresses, you will see how this conversation between Vikas and Dr. Gladden moves from the very basics to the science behind lactate build-up, finally covering all the myths and bro-science revolving around it.Vikas hosts this weekly podcast and enjoys nerding over-exercise physiology, nutrition, and endurance sport in general.  He aims to get people to get out and 'move'.  When he is not working, he is found running, almost always.  He can be found on nearly all social media channels but Instagram is preferred:)Reach out to Vikas:Instagram: @vikas_singhhLinkedIn: Vikas SinghGmail: vikas@fitpage.inTwitter: @vikashsingh1010

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Michael Saag, MD, of the University of Alabama at Birmingham (UAB) about his editorial “Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science.” Dr. Saag is Associate Dean for Global Health in the School of Medicine, Director of the UAB Center for AIDS Research and a Professor of Medicine in the Division of Infectious Diseases. He also is the principal investigator of the CFAR Network of Integrated Clinical Systems (CNICS), a network of centers sharing electronic health record data to integrate clinical information from persons infected with HIV. In addition, Dr. Saag is the founding director of the UAB 1917 HIV Clinic, one of the leading HIV clinics in the United States. Dr. Saag's experience in treating patients with HIV, and advances in HIV treatment [2:50] Why is there no vaccine for HIV? [4:50] Is there an animal vector for SARS-CoV-2 as was the case for SARS-CoV-1? [8:17] What exactly is “long COVID,” and what are its implications for public health? [12:06] Why do vaccinated individuals still contract SARS-CoV-2? [17:08] Final thoughts [22:04] Subscribe to the podcast here. Browse recent articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and on Facebook. Listen to other podcasts produced by the American Physiological Society.

Our guest today is Dr. Elaine Choung-Hee Lee, an assistant professor in the Department of Kinesiology at the University of Connecticut. Much of Elaine's research focuses on understanding the mechanisms of resilience and investigating ways to help humans improve their stress resistance, adaptation and healthspan. Elaine's research is focused not only on understanding fundamental biology, but also on what can be done to manipulate our biology to optimize health and performance as well as preventing disease. At her UConn research center, called the EC Lee Laboratory, she and her colleagues use genomic and other technologies to ask questions about what makes high-performing athletes and warfighters so elite. In today's interview, you'll hear how an early passion for Marvel comics and superheroes helped nudge Elaine into a science career. You'll also learn about some of her lab's projects that range from improving warfighter resilience to studying the effects of exercise and supplementation on our immune functions. Show notes: [00:03:07] Dawn asks Elaine about when she became interested in superheroes. [00:04:02] Elaine shares who her favorite Marvel hero is. [00:05:20] Dawn asks Elaine what her favorite Marvel movie is. [00:05:42] Ken asks when Elaine first became interested in science. [00:06:50] Dawn mentions that Elaine had many obsessions growing up, including running and rowing, and goes on to mention that Elaine even became a rower at the University of Connecticut, asking what drew her to these sports. [00:09:09] Ken asks what Elaine's experience on the rowing team was like. [00:11:43] Dawn mentions that Elaine graduated with her bachelors in nutritional sciences in 2002 and asks if that was her original intent when she first arrived at college. [00:13:38] Dawn asks Elaine to talk about her passion for research and how the focus of her work grew from her experiences as an athlete and coach. [00:16:14] Dawn comments that Elaine's early experiences in genetics and nutritional sciences played a role in her career and asks what some of those early experiences were. [00:17:49] Dawn asks Elaine if it's fair to say that she is not merely interested in biology, but in what people and researchers can do to manipulate biology in a way that can result in functional changes for broader populations. [00:19:13] Ken mentions that Elaine stayed at the University of Connecticut for her masters and doctorate degrees in kinesiology, asking why decided on that specialization. [00:21:34] Dawn mentions that Elaine went for a post-doc fellowship at the Mount Desert Island Biological Laboratory in Salisbury Cove, Maine, and asks how that opportunity came about. [00:23:59] Dawn mentions that during Elaine's post-doc, she and Dr. Kevin Strange co-authored a paper in the journal of Federation of American Societies for Experimental Biology, titled “Osmosensitive gene expression in C elegans is regulated by conserved signaling mechanisms that control protein translation initiation.” Dawn goes on to mention that this paper was selected in 2012 by the Cellular and Molecular Physiology Section of the American Physiological Society as one of six finalists for its annual research recognition award. Dawn asks why this paper attracted such attention. [00:28:56] Ken mentions that Elaine was also selected as the Mount Desert Island Biological Laboratory's “Outstanding Mentor of the Year” in 2012. [00:32:18] Dawn mentions that Elaine's research over the years has focused on understanding the mechanisms of stress resiliency, and ways to improve stress resistance, adaptation and healthspan, asking how Elaine became interested in this angle of research. [00:34:00] Dawn asks Elaine to talk about her use of C elegans and why they are so useful for her research into stress and resilience. [00:38:21] Dawn mentions that Elaine's work on the mechanisms of osmosensing and adaptation in response to osmotic st...

If working out and optimizing your workout routine is an important part of your life, then today's episode about the science of blood flow restriction may offer some fascinating insights and inspiration for you. My guest Dr. Jeremy Loenneke is one of the leading researchers on practical blood flow restriction training, also known as BFR, or occlusion training. Jeremy is going to share his knowledge about the benefits of blood flow restriction, how to apply it during training and the effects on size, strength and recovery of muscles. Jeremy Loenneke has a Ph.D. in exercise physiology, a Master's in nutrition and exercise. He is currently the director of the Kevser Ermin Applied Physiology Laboratory and his research group's primary focus is on skeletal muscle adaptations to exercise with and without the application of blood flow restriction. Jeremy is also a Fellow of the American College of Sports Medicine and a member of the American Physiological Society. In this episode with Jeremy Loenneke, you'll discover: -Jeremy's path to bodybuilding...02:30 -An overview of blood flow restriction (BFR) from the Godfather himself...03:45 -The physiology of blood flow restriction...04:50 -The history of BFR to the present day practice...06:30 -Safety tips for BFR...08:30 -There is a growing body of evidence that BFR could be a good modality for recovery...11:30 -The initial seed of fascination for Jeremy that led to his doctoral studies in the field...12:30 -The importance of muscular health for longevity...14:20 -Fast twitch and slow twitch muscle fibers defined...16:20 -Strength vs. hypertrophy...17:35 -Great muscular strength is often related to muscle size, but not always...19:05 -Practical tips to integrate BFR into your workout...20:35 -Differences in BFR training for athletes vs. the layperson...26:00 -An expert's take on the 5 year projection for BFR training...27:20 -Jeremy's hopes for BFR testing he could do in his lab...29:20 -Exercise and training are practices which impacted Jeremy's life in unexpected and circuitous ways...31:00 Resources mentioned: https://hesrm.olemiss.edu/kevser-ermin-applied-physiology-laboratory/ (Kevser Ermin Applied Physiology Laboratory) Guest's social handles: https://twitter.com/jploenneke (Twitter) https://www.instagram.com/jploenneke/ (Instagram)

What is the relationship between hypertrophy and strength? Does muscle size contribute to muscle strength? - Answer to these questions is provided by Dr. Jeremy Loenneke, the director of the Kevser Ermin Applied Physiology Laboratory. He has a BS in Health Management from the Southeast Missouri State University, an MS in Nutrition and Exercise Science from the Southeast Missouri State University, and a Ph.D. in Exercise Physiology from The University of Oklahoma. Currently, he works at the University of Mississippi, and his research group's primary focus is on skeletal muscle adaptations to exercise with and without the application of blood flow restriction. Also, he is a Fellow of the American College of Sports Medicine and a member of the American Physiological Society.   Jeremy's Google Scholar: https://scholar.google.com/citations?user=VmtuZVsAAAAJ&hl=en . . . . . _______________________ SUPPORT US!   Subscribe to Weightology: https://www.weightology.net/products/traffic.php?id=115 Download TrainHeroic: https://mbsy.co/3GShF2 _______________________ This is the 16th episode of the weekly #coachingcues #podcast! If you want to have your question answered by an expert, please head to www.coachingcues.org/ask --- Send in a voice message: https://anchor.fm/coachingcues/message

James L. Madara, MD, serves as the CEO and executive vice president of the American Medical Association and adjunct professor of pathology at Northwestern University.Dr. Madara has helped sculpt the organization's long-term strategic plan. He also serves as chairman of Health2047 Inc., the wholly-owned innovation subsidiary of the AMA, created to overcome systemic dysfunction in U.S. health care. Prior to the AMA, Dr. Madara spent the first 22 years of his career at Harvard Medical School, receiving both clinical and research training, serving as a tenured professor, and as director of the NIH-sponsored Harvard Digestive Diseases Center. Following five years as chair of pathology and laboratory medicine at Emory University, Dr. Madara served as dean of both biology and medicine, and then as CEO of the University of Chicago Medical Center, unifying the university's biomedical research, teaching and clinical activities. Dr. Madara then served as senior advisor with Leavitt Partners, a health care consulting and private-equity firm founded by former Health and Human Services Secretary Mike Leavitt.Throughout his career, he has published over 200 original papers and chapters and has served as editor-in-chief of the American Journal of Pathology and as president of the American Board of Pathology.Dr. Madara is consistently named one of the nation's 50 most influential physician executives and on the nation's 100 most influential people in health care. Some of his notable awards include the MERIT Award from the National Institutes of Health, the Davenport Award for lifetime achievement in gastrointestinal disease from the American Physiological Society, and the Mentoring Award for lifetime achievement from the American Gastroenterological Society.Welcome to Leading the Rounds!Questions We Asked: What led you to be CEO of the American Medical Association? How did you develop the three arcs of the AMA? What are some targeted things AMA has done to improve physician workflow? What is the goal of Health2047?What does the future of medical education look like? How can medical trainees become involved in innovation in healthcare? What are some book suggestions for medical leaders? Quotes & Ideas: AMA's Three Strategic Arcs: Improving physician satisfaction by removing obstacles that interfere with patient care; Driving the future of medicine by reimagining medical education, training and lifelong learning and by promoting innovation to tackle the biggest challenges in health care; and Improving the health of the nation by leading the charge to prevent chronic disease and confront public health crisesDr. Madara's AMA Startup Health2047 AMA launches Silicon Valley integrated innovation company, Health2047How the AMA works to support medical trainees: AMA announces new online education hub to support lifelong learning, Accelerating Change in Medical EducationThe three legged educational stool: Clinical Science, Basic Science, and Health Systems Science Establish your own personal guiderales. Dr. Madara's include: always take the high road and don't mistake a dropped ball for a conspiracy Book Suggestions: Nudge by Richard H. Thaler Thinking Fast and Slow by Daniel Kahneman

In this episode of Science & Chill, I interview Dr. Tamara Hew-Butler. Dr. Hew-Butler is a podiatric physician and associate professor of Exercise and Sports Science at Wayne State University. She earned her PhD at the University of Cape Town, South Africa, where she studied and trained under the legendary sports scientist and physician Dr. Timothy Noakes. Dr. Hew-Butler is a Fellow of the American College of Sports Medicine (FACSM) and specializes in both sports medicine and exercise physiology. Her expertise is in exercise-associated hyponatremia, a topic we cover in detail, and the hormonal regulation of water and sodium balance. She is also an avid runner. I reached out to Dr. Hew-Butler after reading a cover story on her that appeared in the Physiologist Magazine, which is a monthly publication from the American Physiological Society. You can find a link to that story in the show notes. After reading this story, I immediately contacted Dr. Hew-Butler to invite her on the podcast, because I knew she'd make for a fascinating guest. Given my recent interests in talking about and often debating about, hydration and water drinking on social media, this seemed like a perfect opportunity to interview someone with expertise on all things hydration who has both field and laboratory experience on the topic. In fact, her interest in the topic first began when she was part of the race staff at major road races and observed cases of athletes experiencing sometimes near-fatal cases of “overhydration.”   Links - "A Runner's Quest" (The Physiologist July 2021 cover story) - Follow Dr. Hew-Butler on Twitter (@Hyponaqueen) - Support the podcast on Patreon - Listen and subscribe on Apple Podcasts - Listen and subscribe on Spotify - Claim your FREE LMNT sample pack

Colette Bean, Chief Publishing Officer of the American Physiological Society, discusses the past, present, and future of Physiological Reviews with Editor-in-Chief, Sadis Matalon, PhD. 

Avocado discovery may point to leukemia treatment University of Guelph (Canada), May 1, 2021 A compound in avocados may ultimately offer a route to better leukemia treatment, says a new University of Guelph study. The compound targets an enzyme that scientists have identified for the first time as being critical to cancer cell growth, said Dr. Paul Spagnuolo, Department of Food Science. Published recently in the journal Blood, the study focused on acute myeloid leukemia (AML), which is the most devastating form of leukemia. Most cases occur in people over age 65, and fewer than 10 per cent of patients survive five years after diagnosis. Leukemia cells have higher amounts of an enzyme called VLCAD involved in their metabolism, said Spagnuolo. “The cell relies on that pathway to survive,” he said, explaining that the compound is a likely candidate for drug therapy. “This is the first time VLCAD has been identified as a target in any cancer.” His team screened nutraceutical compounds among numerous compounds, looking for any substance that might inhibit the enzyme. “Lo and behold, the best one was derived from avocado,” said Spagnuolo. Earlier, his lab looked at avocatin B, a fat molecule found only in avocados, for potential use in preventing diabetes and managing obesity. Now he’s eager to see it used in leukemia patients. “VLCAD can be a good marker to identify patients suitable for this type of therapy. It can also be a marker to measure the activity of the drug,” said Spagnuolo. “That sets the stage for eventual use of this molecule in human clinical trials.” Currently, about half of patients over 65 diagnosed with AML enter palliative care. Others undergo chemotherapy, but drug treatments are toxic and can end up killing patients. “There’s been a drive to find less toxic drugs that can be used.” Referring to earlier work using avocatin B for diabetes, Spagnuolo said, “We completed a human study with this as an oral supplement and have been able to show that appreciable amounts are fairly well tolerated.” Supplement betaine treats schizophrenia in mice, restores healthy “dance” and structure of neurons University of Tokyo Graduate School of Medicine, April 19, 2021 A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons’ cellular skeletons. The supplement betaine was first isolated from sugar beets and is often associated with sweetness or umami flavor. Healthy levels of betaine come from both external food sources and internal synthesis in the body. Betaine supplements are already used clinically to treat the metabolic disease homocystinuria.  “I don’t encourage anyone to take betaine for no reason, if a doctor has not recommended it. But, we know this drug is already used clinically, so repurposing it to treat schizophrenia should be safe,” said Project Professor Nobutaka Hirokawa, M.D., Ph.D., from the University of Tokyo Graduate School of Medicine who led the recent research project. Hirokawa has been a member of the Japan Academy, a national honorary organization recognizing scientific achievement, since 2004 and received a Person of Cultural Merit award from the Japanese government in 2013. Schizophrenia is estimated to affect about 1 in 100 people globally and is one of the top 15 leading causes of disability worldwide.  “There are treatments for schizophrenia, but they have side effects and unfortunately there is still no effective drug for patients to take that we can explain biochemically why it works,” explained Hirokawa. Genetic studies of people diagnosed with schizophrenia have found possible links between the disease and variations in the kinesin family 3b (kif3b) gene as well as another gene involved in the body’s internal synthesis of betaine. Hirokawa and his lab members have categorized all 45 members of the kinesin superfamily of genes in mammals, most of which encode motor proteins that move materials throughout the cell. Normally, the KIF3B protein links together with another kinesin superfamily protein and transports cargo throughout a neuron by traveling up and down the cell’s skeleton.  Mice used in the recent research had only one functional copy of the kif3b gene and are often used as an animal model of schizophrenia. These mice avoid social interactions and show the same weak response as human patients with schizophrenia in a test called prepulse inhibition, which measures how startled they are by a sudden, loud sound preceded by a quieter sound. Kif3b mutant mice raised on a diet supplemented with three times the normal amount of betaine had normal behavior, indicating that betaine supplements could treat schizophrenia symptoms.  To figure out why betaine had this effect on mice, researchers grew nerve cells with the kif3b mutation in the laboratory and added fluorescent labels so they could watch the cellular skeleton take shape. The shape of a healthy neuron is reminiscent of a tree: a cell body surrounded by branches, the dendrites, attached to a long trunk, the axon. Kif3b mutant neurons grown in the lab have an unusual, hyperbranched structure with too many dendrites. Similar hyperbranched neurons are also seen in brain samples donated by people with schizophrenia, regardless of what treatments or medications they took while they were alive.  During healthy neuron development, the main body of the cell fills with a skeleton component called tubulin. Meanwhile, the front growth cone of the cell builds outwards in a spiky, erratic dance due to the movements of another skeleton component called filamentous actin. In kif3b mutants, this dancing movement, which experts refer to as lamellipodial dynamics, is noticeably reduced and the division between tubulin and actin is blurred.  The actin in a neuron’s cellular skeleton is assembled in part by another protein called CRMP2. Chemical analyses of the brains of kif3b mutant mice and human schizophrenia patients reveal significant chemical damage to CRMP2, which causes the proteins to clump together. Betaine is known to prevent the type of chemical damage, carbonyl stress, that causes this CRMP2 dysfunction.  “In postmortem brains of schizophrenia patients, CRMP2 is the protein in the brain with the most carbonyl stress. Betaine likely eliminates the carbonyl stress portion of the schizophrenia equation,” said Hirokawa.  By protecting CRMP2 from damage, betaine treatment allows kif3b mutant neurons to build proper structures. With a structurally sound skeleton to navigate, the remaining functional KIF3B protein can shuttle cargo around the cell. Other test tube experiments revealed that KIF3B and CRMP2 can bind together, but their exact relationship remains unclear.  “We know that the amount of betaine decreases in schizophrenia patients’ brains, so this study strongly suggests betaine could be therapeutic for at least some kinds of schizophrenia,” said Hirokawa.  The UTokyo research team is planning future collaborations with pharmaceutical companies and clinical studies of betaine supplements as a treatment for schizophrenia. Study reveals your neighbourhood may affect your brain health University of Wisconsin School of Medicine, April 20, 2021 Middle-aged and older people living in more disadvantaged neighbourhoods — areas with higher poverty levels and fewer educational and employment opportunities–had more brain shrinkage on brain scans and showed a faster decline on cognitive tests than people living in neighbourhoods with fewer disadvantages, according to a new study. The study published in the online issue of Neurology, the medical journal of the American Academy of Neurology. Researchers say such brain ageing may be a sign of the earliest stages of dementia. “Worldwide, dementia is a major cause of illness and a devastating diagnosis,” said study author Amy J. H. Kind M.D., PhD, of the University of Wisconsin School of Medicine and Public Health in Madison. “There are currently no treatments to cure the disease, so identifying possible modifiable risk factors is important. Compelling evidence exists that the social, economic, cultural and physical conditions in which humans live may affect health. We wanted to determine if these neighbourhood conditions increase the risk for the neurodegeneration and cognitive decline associated with the earliest stages of Alzheimer’s disease and dementia.” For the study, researchers identified 601 people from two larger studies of Wisconsin residents. Participants had an average age of 59 and no thinking or memory problems at the start of the study, although 69% had a family history of dementia. They were followed for 10 years. Participants had an initial MRI brain scan and then additional scans every three to five years. With each scan, researchers measured brain volume in areas of the brain linked to the development of Alzheimer’s dementia. Participants also took thinking and memory tests every two years, including tests that measured processing speed, mental flexibility and executive function. Researchers used the residential address of each participant and a measure called the Area Deprivation Index to determine if each participant lived in an advantaged or disadvantaged neighbourhood. Neighbourhoods in the index are determined by census areas of 1,500 residents. The index incorporates information on the socio-economic conditions of each neighbourhood and its residents, ranking neighbourhoods based on 17 indicators including income, employment, education and housing quality. Of all participants, 19 people lived in the 20% of most disadvantaged neighbourhoods in their state and 582 people lived in 80% of all other neighbourhoods in their state. People in the first group were then matched one to four to people in the second group for race, sex, age and education and compared. At the start of the study, there was no difference in brain volume between people living in the most disadvantaged neighbourhoods and those in other neighbourhoods. But in the end, researchers found brain shrinkage in areas of the brain associated with dementia in people in the most disadvantaged neighbourhoods, while there was no shrinkage in the other group. Researchers also found a higher rate of decline on tests that measure the risk of Alzheimer’s disease. “Our findings suggest that increased vigilance by healthcare providers for early signs of dementia may be particularly important in this vulnerable population,” said Kind. “Some possible causes of these brain changes may include air pollution, lack of access to healthy food and healthcare and stressful life events. Further research into possible social and biological pathways may help physicians, researchers and policymakers identify effective avenues for prevention and intervention in Alzheimer’s disease and related dementia.” Limitations of the study included a small number of participants from highly disadvantaged neighbourhoods and a limited geographic setting. Future studies should involve larger and more diverse groups of people over longer periods of time. Alpha-lipoic acid increases collagen synthesis and deposition in nondiabetic and diabetic kidneys University of Belgrade (Serbia), April 21, 2021 According to news originating from Belgrade, Serbia, research stated, “Alpha-Lipoic acid (ALA) is widely used as a nutritional supplement and therapeutic agent in diabetes management. Well-established antioxidant and hypoglycemic effects of ALA were considered to be particularly important in combating diabetic complications including renal injury.” Our news journalists obtained a quote from the research from the University of Belgrade, “The present study evaluated the potential of ALA to affect profibrotic events in kidney that could alter its structure and functioning. ALA was administered intraperitoneally (10 mg/kg) to nondiabetic and streptozotocin-induced diabetic male Wistar rats for 4 and 8 weeks. The effects of ALA were assessed starting from structural/morphological alterations through changes that characterize profibrotic processes, to regulation of collagen gene expression in kidney. Here, we demonstrated that ALA improved systemic glucose and urea level, reduced formation of renal advanced glycation end products (AGEs), and maintained renal structural integrity in diabetic rats. However, profibrotic events provoked in diabetes were not alleviated by ALA since collagen synthesis/deposition and expression of transforming growth factor-beta 1 (TGF-beta 1) and alpha-smooth muscle actin (alpha-SMA) remained elevated in ALA-treated diabetic rats, especially after 8 weeks of diabetes onset. Moreover, 8 weeks treatment of nondiabetic rats with ALA led to the development of profibrotic features reflected in increased collagen synthesis/deposition. Besides the TGF-beta 1 downstream signaling, the additional mechanism underlying the upregulation of collagen IV in nondiabetic rats treated with ALA involves decreased DNA methylation of its promoter that could arise from increased Tet1 expression.” According to the news editors, the research concluded: “These findings emphasize the therapeutic caution in the use of ALA, especially in patients with renal diabetic complication.” Obesity, high-salt diet pose different cardiovascular risks in females, males Medical College of Georgia at Augusta University, April 30, 2021 Obesity and a high-salt diet are both bad for our hearts but they are bigger, seemingly synergistic risks for females, scientists report. “We see younger and younger women having cardiovascular disease and the question is: What is the cause?” says Dr. Eric Belin de Chantemele, physiologist in the Vascular Biology Center and Department of Medicine at the Medical College of Georgia at Augusta University. “We think the fact that females are more salt sensitive and more sensitive to obesity are among the reasons they have lost the natural protection youth and estrogen are thought to provide.”  His message to women based on the sex differences they are finding: “First reduce your consumption of salt, a message the American Heart Association has been pushing for years, which should also result in a reduction in your intake of highly processed, high-calorie food and drink.” Belin de Chantemele, whose research team has been exploring why so many young women are now getting cardiovascular disease, is presenting their findings during the Henry Pickering Bowditch Award Lectureship at the American Physiological Society Annual Meeting at Experimental Biology 2021 this week. The award, which honors the scientist who created the first physiology lab in the country and was the American Physiological Society’s first president, recognizes original and outstanding accomplishments in the field of physiology by a young investigator.  The sex hormone estrogen, which has some protective powers like keeping blood vessels more flexible, is considered a natural protection for premenopausal women yet, along with soaring rates of severe obesity in young women, heart disease is now the third leading cause of death in females between the ages 20-44 — fourth for males in that age group — then moves up to second place for the next 20 years in both sexes, and is the number one killer for both men and women looking at all ages, according to the National Vital Statistics Reports.  While he refers to bad nutrition as the “world’s biggest killer” and obesity as a major risk factor for hypertension in both sexes, his lab has mounting evidence that obesity and high salt intake are even bigger risks for females, who have naturally higher levels of two additional hormones, leptin and aldosterone, setting the stage for the potentially deadly cardiovascular disparities.  Many of us likely think of leptin as the “satiety hormone” that sends our brain cues to stop eating when our stomach is full, but in obesity, the brain typically stops listening to the full message but the cardiovascular system of women starts getting unhealthy cues.  Belin de Chantemele has shown that in females leptin prompts the adrenal glands, which make aldosterone, to make even more of this powerful blood vessel constrictor. Like leptin, females, regardless of their weight, already have naturally higher levels of aldosterone and actually bigger adrenal glands as well.  A result: Obesity actually produces larger blood pressure increases in females, and studies indicate that females also are more prone to obesity associated vascular dysfunction — things like more rigid blood vessels that are not as adept as dilating. On the other hand, leptin actually increases production of the vasodilator nitric oxide — which reduces blood pressure — in the male mice, one of many cardiovascular differences they are finding between males and females.  Here’s another. “The major role of aldosterone is to regulate your blood volume,” Belin de Chantemele says. Increased salt intake should suppress aldosterone, and it does work that way in males, Belin de Chantemele says. But in females it appears to set them up for more trouble.  Aldosterone is the main mineralocorticoid, a class of hormones that helps maintain salt balance, and Belin de Chantemele and his team reported in 2019 in the journal Hypertension that the hormone progesterone, which enables pregnancy, also enables high levels of these mineralocorticoid receptors for aldosterone in the endothelial cells that line blood vessels in both female lab animals and human blood vessels.  When they removed the ovaries, which make estrogen and progesterone, from the female lab animals it equalized the mineralocorticoid receptor number, helping confirm that progesterone regulates the expression of the receptor in the females’ blood vessels. When they deleted either the mineralocorticoid or progesterone receptor in the females, it prevented the blood vessel dysfunction that typically follows, and just knocking out the progesterone receptor also suppressed the aldosterone receptor. The bottom line is that progesterone is key to the sex difference in aldosterone receptor expression on endothelial cells, which predisposes females to obesity associated, high-leptin driven endothelial dysfunction and likely high blood pressure, Belin de Chantemele says.  They reported a few years before in the same journal that higher leptin levels produced by more fat prompts the adrenal glands to make more aldosterone in females. “If you have higher aldosterone levels you will retain sodium and your blood volume will be higher,” he says.  They’ve also reported, as have others, that females are more salt sensitive than males. High sodium intake is known to raise blood pressure, by increasing fluid retention, and both pre- and postmenopausal females are more salt sensitive than males, Black females even more so, he says.  They’ve shown, for example, that in just seven days on a high-salt diet, the ability of female mice to relax blood vessels decreased as blood pressure increased. Treatment with the aldosterone agonist eplerenone helped correct both.  Because females already make more aldosterone, and the normal response of the body when you eat a lot of salt is to make even more aldosterone to help eliminate some of it, his team now proposes that females appear to have an impaired ability to reduce both the levels of the enzyme that makes aldosterone and the hormone itself, which makes them more salt sensitive.  One thing that means is that salt raises females’ blood pressure without them actually retaining more salt than the males. It also means that they think that blood vessels are more important in blood pressure regulation in females than males, which means they may need different treatment than males. To further compound the scenario, high salt increases the adrenal leptin receptor in the females, providing more points of action for leptin, which probably helps explain why aldosterone levels don’t decrease in females like they do in males.  A new $2.6 million grant (1R01HL155265-01) from the National Heart, Lung and Blood Institute is enabling them to further investigate, in both lab animals and human tissue, the female’s unique responses to a high-salt diet, include the specific contributions of the failure of aldosterone levels to drop, along with the increased expression of aldosterone and leptin receptors.  While trends in being overweight in about the last 50 years have held pretty steady for men and women, with decreases for men in the last handful of years, rates of severe obesity have been climbing, with women far outpacing men.  “We want to continue to put the puzzle together with the goal of helping restore protection from cardiovascular disease to young women, when a healthy diet and increased physical activity do not,” Belin de Chantemele says.  His research team includes Galina Antonova, research assistant; Dr. Reem Atawia, postdoctoral fellow; Simone Kennard, research associate; Taylor Kress and Candee Barris, graduate students; Vinay Mehta, undergraduate student at AU, Laszlo Kovacs, assistant research scientist; and Dr. Jessica Faulkner, postdoctoral fellow. Just 10 minutes of meditation helps anxious people have better focus University of Waterloo (Canada) May 1, 2021  Just 10 minutes of daily mindful meditation can help prevent your mind from wandering and is particularly effective if you tend to have repetitive, anxious thoughts, according to a study from the University of Waterloo. The study, which assessed the impact of meditation with 82 participants who experience anxiety, found that developing an awareness of the present moment reduced incidents of repetitive, off-task thinking, a hallmark of anxiety. “Our results indicate that mindfulness training may have protective effects on mind wandering for anxious individuals,” said Mengran Xu, a researcher and PhD candidate at Waterloo. “We also found that meditation practice appears to help anxious people to shift their attention from their own internal worries to the present-moment external world, which enables better focus on a task at hand.” The term mindfulness is commonly defined as paying attention on purpose, in the present moment, and without judgement. As part of the study, participants were asked to perform a task on a computer while experiencing interruptions to gauge their ability to stay focused on the task. Researchers then put the participants into two groups at random, with the control group given an audio story to listen to and the other group asked to engage in a short meditation exercise prior to being reassessed. “Mind wandering accounts for nearly half of any person’s daily stream of consciousness,” said Xu. “For people with anxiety, repetitive off-task thoughts can negatively affect their ability to learn, to complete tasks, or even function safely. “It would be interesting to see what the impacts would be if mindful meditation was practiced by anxious populations more widely.” The study, co-authored by Waterloo psychology professors Christine Purdon and Daniel Smilek and Harvard University’s Paul Seli, was published in Consciousness and Cognition. Researchers find breastfeeding linked to higher neurocognitive testing scores University of Rochester Medical Center, April 27, 2021 New research finds that children who were breastfed scored higher on neurocognitive tests. Researchers in the Del Monte Institute for Neuroscience at the University of Rochester Medical Center (URMC) analyzed thousands of cognitive tests taken by nine and ten-year-olds whose mothers reported they were breastfed, and compared those results to scores of children who were not. “Our findings suggest that any amount of breastfeeding has a positive cognitive impact, even after just a few months.” Daniel Adan Lopez, Ph.D. candidate in the Epidemiology program who is first author on the study recently published in the journal Frontiers in Public Health. “That’s what’s exciting about these results. Hopefully from a policy standpoint, this can help improve the motivation to breastfeed.” Hayley Martin, Ph.D., a fourth year medical student in the Medical Scientist Training Program and co-author of the study, focuses her research on breastfeeding. “There’s already established research showing the numerous benefits breastfeeding has for both mother and child. This study’s findings are important for families particularly before and soon after birth when breastfeeding decisions are made. It may encourage breastfeeding goals of one year or more. It also highlights the critical importance of continued work to provide equity focused access to breastfeeding support, prenatal education, and practices to eliminate structural barriers to breastfeeding.” Researchers reviewed the test results of more than 9,000 nine and ten-year-old participants in the Adolescent Brain Cognitive Development (ABCD) study. Variations were found in the cumulative cognitive test scores of breastfed and non-breastfed children. There was also evidence that the longer a child was breastfed, the higher they scored.  “The strongest association was in children who were breastfed more than 12 months,” said Lopez. “The scores of children breastfed until they were seven to 12 months were slightly less, and then the one to six month-old scores dips a little more. But all scores were higher when compared to children who didn’t breastfeed at all.” Previous studies found breastfeeding does not impact executive function or memory, findings in this study made similar findings. “This supports the foundation of work already being done around lactation and breastfeeding and its impact on a child’s health,” said Ed Freedman, Ph.D., the principal investigator of the ABCD study in Rochester and lead author of the study. “These are findings that would have not been possible without the ABCD Study and the expansive data set it provides.”

Goodathleteproject.com For Today's episode we sat down with Timothy E. Hewett, Ph.D.. Dr. Hewett is a former Director of The Biomechanics Laboratories and Sports Medicine Research Center at Mayo Clinic, Director of the Sports Health & Performance Institute at The Ohio State University, Professor and Director of Sports Medicine Research at OSU, and Professor and Director of the Sports Medicine Biodynamics Center at Cincinnati Children's Hospital and Research Foundation. He was a Professor in Sports Medicine, Family Medicine, Orthopaedic Surgery, Physiology and Cell Biology and Biomedical Engineering and Allied Health Professions at The OSU, Pediatrics and Orthopaedic Surgery at the University of Cincinnati College of Medicine, and Professor in Rehabilitation Sciences at the University of Kentucky. Dr. Hewett possesses a doctorate in Physiology and Biophysics and a postdoctoral fellowships in Molecular Biology & Biomechanics, Pharmacolgy and Cell Biophysics and Human Biomechanics. Over four hundred of his research articles have appeared in peer-reviewed medical journals, with over 50,000 citations of his work in the medical literature. Dr. Hewett has an h-index over 113 and his research has received numerous awards, including the Excellence in Research Award, The O'donohue Award and the NCAA Award from the American Orthopaedic Society for Sports Medicine, The Rose Excellence in Research Award from The American Physical Therapy Association, The Research to Reality and Clint Thompson Awards from National Athletic Trainers Associations and the Young Investigator Award from the American Heart Association Dr. Hewett is a Fellow of American College of Sports Medicine and a member of the American Orthopaedic Society for Sports Medicine, the Orthopaedic Research Society & American Physiological Society.

In this episode of the KoopCast Coach Jason Koop speaks with Stavros Kavouras.Dr. Stavros Kavouras is Assistant Dean and Professor of Nutrition at Arizona State University. He is the Director of the Hydration Science Lab where he is studying the mechanisms by which water intake impacts health and performance. Dr. Kavouras is the author of more than 130 peer review articles and he has given lectures in 29 countries. He is a section-Editor of the European Journal of Nutrition and Frontiers in Nutrition. Dr Kavouras is a Fellow of the American College of Sports Medicine & the European College of Sports Science and elected member of the American Physiological Society and the American Society of Nutrition.

Dr. Dominic D’Agostino is a leading researcher into the therapeutic effects of the ketogenic diet. He is featured on Joe Rogan, Tim Ferriss, Impact Theory, TED, and dozens of other top media outlets. This is a wide-spanning conversation on high fat diets, time-restricted feeding, fasting, and even nutrition psychotherapy.Who is Dr. Dominic D’Agostino? Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer. To investigate the mechanism of these pathologies he uses a variety of in vivo and in vitro techniques, including radio-telemetry (EEG, EMG), electrophysiology, fluorescence microscopy, confocal microscopy, atomic force microscopy (AFM), biochemical assays and in vivo bioluminescence imaging. His laboratory has adapted many of these techniques for use inside environmental chambers, which allows them to manipulate oxygen concentrations (from hypoxia to hyperbaric oxygen). His current project is to identify cellular mechanisms of seizures from CNS oxygen toxicity and to develop mitigation strategies against it. His efforts have focused specifically on measuring brain EEG, neuronal excitability, reactive oxygen species (ROS) production and biomarkers of oxidative stress. The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. The shift in brain metabolism (from glucose to ketones) reduces neuronal hyperexcitability, oxidative stress and enhances brain energy metabolism. This approach can be used to treat a wide variety of pathologies linked pathophysiologically to metabolic dysregulation, including cancer. Other areas of interest include researching drugs that target cancer-specific metabolic pathways. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.With a wide range of research interests, Dominic D’Agostino holds membership in the Undersea and Hyperbaric Medicine Society, Aerospace Medical Association, Society of Neuroscience, American Physiological Society, and the American Association of Cancer Research, additionally serving on numerous editorial boards and as a Reviewer for dozens scholarly publications. Before joining the faculty at USF, D’Agostino completed a postdoctoral fellowship in neuroscience at Boonshoft School of Medicine at Wright State University. A graduate of Robert Wood Johnson Medical School and Rutgers University, Dominic D’Agostino earned his Ph.D. and B.S. from these respective institutions.Highlights[3:44] Making two different diets work at home[7:14] Life underwater for 10 days[20:01] APOE4 and the Ketogenic diet's effects on Alzheimer's disease [27:37] Effects of removing dairy and saturated fat on biomarkers[33:21] The ketogenic diet and atherosclerosis[37:40] How to build muscle in ketosis[41:27] Taking a year off from weightlifting[47:40] How to lose the benefits of intermittent fasting[54:10] Dr. Dom’s opinion on one meal a day[56:16] Should you schedule cheat meals?[1:06:00] The importance of micronutrients[1:08:05] The best keto snacks[1:13:40] Adherence and ketosisResourcesNASA NEEMONEEMO 22 Photo GalleryThe Charlie FoundationByrd Alzheimer's InstituteMary NewportDr. Dom’s BlogPractical Guides to the Keto DietSponsorsKeto Nutritionketonutrition.org is Dr. Dominic D’Agostino’s personal website. If you go there and purchase any of the products available, you will be donating to Dr. Dom’s research. 100% of profits go to Dr. D'Agostino's time. Please head on over to ketonutrition.org/support and discover the ways that you can help Dr. Dominic and his team achieve their goals.BiOptimizersMost supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. That’s why I’m so excited to tell you about a new magnesium product I’ve been taking now called, Magnesium Breakthrough. It’s the ULTIMATE magnesium supplement, easily the best I’ve ever seen or experienced... with all 7 forms of this mineral.I’m even more excited because it’s finally BACK IN STOCK! Magnesium Breakthrough has been selling faster than the company who makes it, BiOptimizers, has been able to keep up with. It’s already sold out a few times and due to supply shortages with everything going on in the world, it could very well be sold out again shortly.I was able to arrange for some stock to be set aside just for our audience and I guarantee it’s the BEST deal available on this product. Seriously! With volume discounts combined with our custom 10% coupon code, BOOMER, you can save up to 40% off select packages of Magnesium Breakthrough! That’s an AMAZING value. And I promise that deal is ONLY available on this specific website, www.magbreakthrough.com/boomerMagnesium Breakthrough is the most effective magnesium supplement I’ve ever tried. Say goodbye to having to buy 7 different bottles of magnesiums to get the complete dose.Go to www.magbreakthrough.com/boomer and use coupon code BOOMER to save up to 40% off select packages to get the most full-spectrum and effective magnesium product ever.Continue Your High Performance Journey with Dr. Dom D’AgostinoWebsiteInstagramFacebookTwitterYouTubeDisclaimer This information is being provided to you for educational and informational purposes only. This is being provided as a self-help tool to help you understand your genetics, biodata and other information to enhance your performance. It is not medical or psychological advice. Virtuosity LLC, or Decoding Superhuman, is not a doctor. Virtuosity LLC is not treating, preventing, healing, or diagnosing disease. This information is to be used at your own risk based on your own judgment. For the full Disclaimer, please go to (Decodingsuperhuman.com/disclaimer). See acast.com/privacy for privacy and opt-out information.

La diáspora Mexicana en los Estados Unidos de América cuenta con un gran promotor de la educación para los estudiantes Mexicanos y Latinos. Te invito a escuchar con mucho cuidado esta conversación con el Dr. Héctor Rasgado-Flores y tendrás la oportunidad de conocer a un notable músico, científico y profesor en la Rosalind Franklin University in North Chicago. Te recomiendo escuchar sus obras en youtube : Body Notes y The elements. El Dr. Rasgado nos comenta de su trabajo, de su música pero sobre todo de los programas dedicados a mejorar la representación de estudiantes mexicanos y latinos en la ciencia y la medicina. En dos años los programas iniciados por el Profesor Héctor Rasgado Flores tendrán los primeros frutos, egresarán e 2022 los primeros estudiantes guiados desde la escuela preparatoria. Dr. Hector Rasgado-Flores is the Director of Diversity, Outreach and Success and a Professor of Physiology and Biophysics at Chicago Medical School at Rosalind Franklin University in North Chicago. He is a conservatory-trained pianist and composer who went to medical school but decided instead to pursue a career in basic sciences research and studied a Master’s and doctorate in Neurosciences and went through the ranks of an academic career performing biophysical research and teaching graduate and medical students. Contrary to common practice, he decided not to choose between his passions for research, education and music, but decided instead to simultaneously fully follow all these paths to the best of his abilities. The result has been a rich and rewarding life: a scientist who continues helping develop new and better therapies to treat cystic fibrosis; a pianist who gives concerts on a regular basis in such venues as the Mozarteum in Salzburg, the Paraninfo in Guadalajara, Moscow State University, and the Chicago Cultural Center; a composer who has written a symphony about the physiology of the human life cycle, commissioned by the American Physiological Society, and which has been performed by outstanding symphony orchestras in the Americas; a researcher who studies the effects of music in children and on elderly dementia patients; a composer who wrote a piano suite about the chemical elements commissioned by the Colegio Nacional in Mexico; an educator who teaches medical students the mechanisms of skeletal muscle contraction using as models XVIII century Italian operas, and who organizes workshops to teach non-musician medical students to compose four voices music cannons. However, most importantly, as he clearly states at every opportunity, an educator whose goal and greatest reward is to bring underserved, underrepresented in medicine students to higher education. hector.rasgado@rosalindfranklin.edu #agavecultura #agavelessons #agave #mezcal #mezcalovers #maguey #agavelovers #bacanora #raicilla #sotol #comiteco #agaveducation #agaveducators #agaveSpirits #agaveSyrup #AnaValenzuelaZ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/ana-g-valenzuela-zapata/message

In this episode, I talk with Dr. Jeremy Loenneke. Dr. Loenneke, an expert in the field of Blood Flow Restriction research, explains the basics of Blood Flow Restriction, how/where/when to fit BFR into your training, and how BFR can benefit athletes of all types. He also gives us some practical advice for how to approach disagreements.Dr. Loenneke is an Assistant Professor of Exercise Science at The University of Mississippi within the School of Applied Sciences. He received his MS in Nutrition and Exercise Science from Southeast Missouri State University and his PhD in Exercise Physiology from the University of Oklahoma. He is the director of the Kevser Ermin Applied Physiology Laboratory and his research group’s primary focus is on skeletal muscle adaptations to exercise with and without the application of blood flow restriction. Dr. Loenneke is a Fellow of the American College of Sports Medicine and a member of the American Physiological Society. He currently serves on the editorial board for Sports Medicine, PLOS One, and the Journal of Trainology.Follow Dr. Loenneke:Instagram: @jploennekeTwitter: @jploenneke

Scott Steen, FASAE, CAE, is the executive director of the American Physiological Society, where he has initiated major change initiatives aimed at growing membership, diversifying revenue, increasing member value and streamlining governance. He previously served as the president & CEO of American Forests and the executive director of the American Ceramic Society. The American Physiological Society is a global multidisciplinary community of scientists solving the major problems affecting life and health.

We're kicking off Season 2 of the ACSM - EOPIG podcast with Dr. Nina Stachenfeld from the John B. Pierce Laboratory at Yale University. Links to the articles we discuss in the first half of the episode can be found here Androgens Drive Microvascular Endothelial Dysfunction in Women with Polycystic Ovary Syndrome: role of endothelin B receptor Women Leading in the Environmental and Exercise Physiology Section of the American Physiological Society: better late than never

Steve and Caleb are back and in this episode, they are back to discussing science straight out of the gate. Steve has been reading research about Amyotrophic Lateral Sclerosis (ALS) and he talks a bit about that. This leads to a discussion on the balance of perfection and practicality in science. Sometimes it is hard to figure out when enough is enough when designing an experiment. Sometimes the benefit is not worth all of the work it will take. Next, the guys talk about some career options that are available with a biology degree. When Caleb and Steve were undergrads they weren't aware of all of the possible careers in biology. They also talk about presenting science at meetings. Steve is hoping to present his thesis research at an American Physiological Society meeting this year. Caleb also gives some advice on giving an interesting presentation. Finally, they end with some speculation on the role of robots in society. Inevitably, they get on the "will the robots take over the world?" debate and Caleb picks his evil robot apocalypse weapon of choice. This is a fun science filled episode, check it out! Website Facebook Instagram Twitter

Dominic D'Agostino, Ph.D., delivers an informative overview of the potential positive impact of ketogenic diets for disease prevention and treatment. He discusses how many cancers such as endometrial cancer and pancreatic cancer are associated with hyperglycemia, which is a hallmark of type II diabetes.D'Agostino is a tenured professor at the University of South Florida. Working with students at the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, D'Agostino's primary focus is in the areas of neuroscience and neuropharmacology, medical biochemistry, and physiology.  As a research scientist at the Institute for Human and Machine Cognition, D'Agostino aggressively pursues his research in methods to optimize and maximize the health, safety, and resilience of soldiers in combat, as well as astronauts. As a laboratory scientist D'Agostino and his team develop and test various metabolic-based strategies for seizures, epilepsy, cancer, and select neurodegenerative diseases. His primary focus for over a decade has been centered upon the many potential anticonvulsant and neuroprotective mechanisms of a ketogenic diet as well as ketone metabolite supplementation. D'Agostino is an active member of the Undersea and Hyperbaric Medicine Society, Society of Neuroscience, Aerospace Medical Association, American Physiological Society, and the American Association of Cancer Research. He holds a Ph.D. and BS from the esteemed Robert Wood Johnson Medical School and Rutgers University, respectively. D'Agostino discusses his current and primary focus on brain cancer and how the ketogenic diet has historically been used to treat epilepsy, thus brain tumor patients experiencing seizures may see significant benefit from a dietary change to this low-carb, high-fat, protein-adequate diet. He talks about the Warburg effect, the phenomenon in which cancer cells produce extra energy via increased oxygen-dependent glycolysis that is then followed by lactic acid fermentation with a secretion of lactate. D'Agostino provides information on cell metabolism; the ATP molecule, which is the nucleotide specifically known in biochemistry as the ‘molecular currency' of cell to cell energy transfer; as well as mitochondria and the links between diet and some cancers. The nutrition and health Ph.D. outlines other important and relevant studies, such as the work of Valter Longo, the Italian-American biogerontologist and cell biologist who is known primarily for his study of the role fasting and nutrient response genes play in disease and cellular protection. Additionally, he discusses the protective effects of short-term dietary restrictions as well as fasting, and the potential importance of ketones for metabolic health. While weight loss is essentially a good side effect of a ketogenic diet, the metabolic benefits provide even more advantages, in addition to the healthy effect of losing weight. He discusses the beneficial impact of decreasing glucose availability to tumors and implementing dietary restrictions as part of a treatment plan for some cancers. The shift in brain metabolism from glucose to ketones can actually reduce neuronal hyperexcitability and oxidative stress, which can enhance brain energy metabolism. D'Agostino feels this methodology can be used to treat a vast array of pathologies, including cancer.   Additionally, D'Agostino presents an important analysis of the microbiome, which is the community of microorganisms such as fungi, bacteria, and viruses that inhabit a specific environment, especially in regard to microorganisms living within or on the human body. He provides his opinion on the variations in microbiomes and how the optimal microbiome can differ based upon food eaten, geographical location, and other factors, and how a ketogenic diet and periodic fasting can help purge the overgrowth of the microbiome, and help return the body to balance. And D'Agostino discusses the glucose-ketone index, and how individuals seeking a healthier dietary balance and increased energy can monitor their index to ensure they are reaching ketosis with regularity for maximum health benefits.

Joining Ben today is Dr. Jeremy Loenneke, assistant professor of Health, Exercise Science & Recreation Management  at The University of Mississippi. Ben and Jeremy dive deep on blood flow restriction training, the most common myths of strength and hypertrophy training and how pro athletes will be training in the near future. Bio “Jeremy’s research focuses on skeletal muscle adaptations to exercise in combination with blood flow restriction. His recent work has answered several important methodological and safety questions with respect to applying blood flow restriction. Dr. Loenneke is a member of the American College of Sports Medicine and the American Physiological Society. He also serves as a peer reviewer for several journals including Sports Medicine, AGE, Medicine and Science in Sports and Exercise, and the Journal of Applied Physiology.”   Full show notes at: http://bit.ly/2CIl9XQ Key Highlights ⇾ The truth behind the mechanisms of hypertrophy, what you don’t know.  ⇾  Is periodization better than progressive overload? ⇾ How the best athletes on the planet will be training in 10 years. ⇾ How to be a part of the new hypertrophy execution masterclass. Time Stamps:  3:24 – Is periodization better than progressive overload? 4:00 – Hans Selye, general adaptation syndrome research.  6:10 – Ben’s approach to programming, explained.  9:35 – The glaring problem with the bigger you get the stronger you get thought process. Jeremy’s  current research.  12:44 – The mechanisms of hypertrophy, what you don’t know.  20:15 – Hypertrophy myths. 29:40 – Acute changes in hormones and its influence on muscle hypertrophy. 32:00 –  The Hypertrophy Masterclass   38:00 – Blood flow restriction training, who is it for? Who is it NOT for?  45:54 – The goal of blood flow restriction training.  48:25 – Best applications for blood flow restriction training.  55:53 – The future of high-performance athlete training in the next 10 years.   Connect with Jeremy Facebook Twitter  Instagram Connect With Ben  Facebook Twitter  Instagram Sponsors  This podcast is brought to you by Prime Fitness USA,  bringing you the most innovative strength training equipment using their patented SmartStrength technology. This podcast is brought to you by ATP Lab! For cutting-edge supplementation with a purpose, check out ATP Labs. This podcast is made possible by Gasp! Top notch quality training wear, Muscle Expert approved training gear! Get 10% off when you use the discount code BEN10 at checkout at Gasp Online Today!

I had the pleasure of meeting one of the great minds of the medical world, Dr. Virginia M. Miller.  Her research into sex hormones and sex differences is groundbreaking in the treatment of individuals based on how a disease affects them as either male or female. More on Dr. Virginia M. Miller: Dr. Miller's research focuses on how sex hormones, such as estrogen and testosterone, affect the blood vessels and heart in women and men, as well as the role of other gender differences in cardiovascular health. An important part of her research is to advocate for research that is sex-specific, meaning that research studies include both men and women, and that the results are analyzed separately by sex. Historically, and today even, that has not always happened, but it is so important, Dr. Miller says. “It is poor science to study one sex and apply the results to the other,” she says. “In the end, that does not help health care providers treat patients the best they can. With heart disease still as the No. 1 cause of death in women and men, we need to continue to research in the best ways possible in order to treat heart disease.” Dr. Miller was the principal investigator for the Mayo site of the multicenter clinical trial, Kronos Early Estrogen Prevention Study (KEEPS) and is currently the principal investigator for the Specialized Center of Research on Sex Differences. She also has authored more than 250 original publications and reviews. In addition to serving on grant review panels and editorial boards for scientific journals, she served as a member of the governing council for the American Physiological Society and as President of the Organization for the Study of Sex Differences. More on Brett Berhoff: Sought after by Corporations and Individuals, Brett Berhoff is known for his innovative thought leadership and strategic expertise.  Alongside his entrepreneurial endeavors, Brett produces the “Brett Berhoff Experience,” a journey inside the minds of the most impressive game changers who shape our planet.  Interviewing everyone from Dr. Amit Sood, the stress reduction guru of Mayo Clinic, to the world famous Paul Reed Smith, who builds guitars for Blake Shelton and John Mayer.  

Dr. Galpin har vært assisterende professor ved California State University, Fullerton, siden 2011, men tilbrakte de første 18 årene av sitt liv i landlige sørvest (Rochester) Washington. Han var heldig nok til å vinne et Divisjon III nasjonal mesterskap i fotball mens han fikk sin bachelorgrad i utøvelsesvitenskap ved Linfield College (2005). Derfra brukte Dr. Galpin sin tid som en styrke og kondisjonering / ytelse coach for en rekke kunder som inkluderte mange profesjonelle atleter (MMA, BJJ, MLB, NFL, NHL, PGA, Special Forces, etc.) så vel som ulike kliniske populasjoner (diabetikere, permanent funksjonshemmet, hjerneslag, overvekt, etc.). Han tok sin mastergrad i Human Movement Sciences fra University of Memphis (2008) og hans Ph.D. i human bioenergetikk fra Ball State University (2011). Dr. Galpin er et aktivt medlem av National Strength and Conditioning Association, American College of Sports Medicine, og American Physiological Society, og er fortsatt aktivt trener / konkurrerer i vektløfting (olympisk stil) og brasiliansk Jiu-Jitsu. Interessegruppe: Dr. Galpins forskningsinteresser omfatter kroniske tilpasninger til menneskets skjelettmuskulatur (både på hele muskel- og enkeltcellens nivå) etter høy intensitet / hastighet / kraftøvelse.  Vi snakker om følgende: Hva er melkesyre Gå fremfor å ligge Kreatin dosering Hvit og beige kroppsfett Langsom og raske muskelfibre BCAA - Skal du bruke det og hvor mye Muskelminne - Hvordan bruke det til din fordel Hypotrofi - hva er det hvordan skal du bruke den Kortisol og hvordan påvirker det muskelfibre og vekst Fett eller karbohydrater eller begge deler? Det finnes ingen "One size fits all" Hva er Unplugged, og hvorfor skal du tilpasse den livsstilen? Steroider Med mer Vil du begynne med mentaltrening? Sjekk ut www.mtfranknilsen.no eller post@mtfranknilsen.no  

The research laboratory of Virginia M. Miller, Ph.D., focuses on conditions specific to women: ovarian function, preeclampsia of pregnancy and menopause. These conditions are associated with dramatic changes in one of the sex steroids, estrogen, and can accelerate development of chronic conditions including cardiovascular disease and aging processes. Dr. Miller's work evaluates how estrogen affects progression of atherosclerosis, and changes in brain structure and cognition at menopause. For these studies, she works collaboratively with other researchers associated with the Rochester Epidemiology Project, the Alzheimer's Disease Research Center, the Center for Translational Science Activities and the Women's Health Research Center. Her group utilizes state-of-the-art imaging modalities and is developing a technique to detect early stages of calcifying processes. Focus areas How do sex hormones affect progression of cardiovascular disease in menopausal women? Dr. Miller is examining how the sex steroid hormone estrogen affects the lining of the blood vessels, which is called endothelium; the activity of platelets, which are required for blood to clot; and the formation of small cell-derived vesicles in the blood. Together, the interaction of these cells and vesicles can lead to vascular changes associated with pregnancy or later in life may cause formation of lesions in the arterial wall, leading to heart attack, stroke, cognitive decline or formation of blood clots in the veins. How does infection alter the risk of developing cardiovascular disease? Dr. Miller's group is interested in learning how bacteria interact with cells of the blood vessel wall and cells in the blood that fight infection. Her group is examining whether small vesicles shed by bacteria that contain bacterial proteins and DNA alter the function of human cells, leading to the development of calcium deposits associated with "hardening" of the arteries and formation of kidney stones. Can monitoring small membrane-derived vesicles released from activated cells and nano-sized particles containing proteins and minerals be developed as a diagnostic for calcifying diseases? Deposits of calcium in the wall of blood vessels accumulate over many years without any outward signs or symptoms. Dr. Miller and her collaborators are working to develop a test to detect the ongoing calcification process so that treatments can stop or retard the calcification before the artery becomes blocked or the calcium deposit is released to cause a heart attack. Significance to patient care Dr. Miller's research into how sex steroid hormones, such as estrogen and testosterone, affect blood flow to the brain, heart and kidneys has direct application to understanding the benefit and harm of using these hormones to treat symptoms of menopause in women; "low testosterone" in men; and chronic conditions, such as cardiovascular disease, cognitive decline and osteoporosis, in both women and men as they age. Professional highlights Principal Investigator, Specialized Center for Research of Sex Differences, Mayo Clinic, 2012-present Principal Investigator, Mayo Clinic's Building Interdisciplinary Research Careers in Women's Health (a National Institutes of Health-funded training program for junior faculty), 2010-present Member, Board of Directors, Bethesda Lutheran Communities, 2010-present Member, Cardiovascular Network of the Society for Women's Health Research, 2009-present President, Organization for the Study of Sex Differences, 2010-2012 Member, Council, American Physiological Society, 2002-2005 Current Member, Editorial Board — American Journal of Physiology: Heart and Circulatory Physiology; Biology of Sex Differences; Journal of Pharmacology and Experimental Therapeutics; The Journal of Clinical Endocrinology & Metabolism; Journal of Cellular and Molecular Medicine Contact miller.virginia@mayo.edu

Jim Stoppani received his doctorate in exercise physiology with a minor in biochemistry from the University of Connecticut. Following graduation, he served as a postdoctoral research fellow in the prestigious John B. Pierce Laboratory and Department of Cellular and Molecular Physiology at Yale University School of Medicine, where he investigated the effects of exercise and diet on gene regulation in muscle tissue. He was awarded the Gatorade Beginning Investigator in Exercise Science Award in 2002 by the American Physiological Society for his groundbreaking research. He has written thousands of articles on exercise, nutrition and health and is author of Encyclopedia of Muscle & Strength, co-author of the New York Times Bestseller, LL Cool J's Platinum 360 Diet and Lifestyle, co-author of the book Stronger Arms & Upper Body, and co-author of the chapter "Nutritional Needs of Strength/Power Athletes" in the textbook Essentials of Sports Nutrition and Supplements. Dr. Stoppani is the creator of the Platinum 360 Diet as found in the book, LL Cool J's Platinum 360 Diet and Lifestyle and creator of the diet program found in the book, Mario Lopez's Knockout Fitness. Dr. Stoppani has been the personal nutrition and health consultant for numerous celebrity clients, such as LL Cool J, Dr. Dre, Dwayne "The Rock" Johnson, and Mario Lopez, and has appeared on the NBC television show Extra as an Extra LifeChanger and as a science expert on the Spike television shows Jesse James is a Dead Man and MANswers.The SMARTER Team Training Audio Interview Series has been developed to share insights from some of the best in the industry. Stay tuned for more insights, tips, drills, and techniques to come from STT. Be sure to share the STT Audio Interview Series with coaches, trainers, parents, and athletes too.Visit STT at http://www.SMARTERTeamTraining.com . Listen to STT on iTunes and iHeartRadio at http://sttpodcast.com . Join STT on Facebook at http://www.facebook.com/SMARTERTeamTraining . Subscribe to STT on YouTube at http://www.youtube.com/SMARTERTeamTraining . And follow us on twitter at http://www.twitter.com/SMARTERTeam . SMARTER Team Training has been developed to focus on athlete and team development, performance, and education. By incorporating the SMARTER Team Training programs into your year round athletic development program, you will decrease your injury potential, increase individual athleticism, and maximize your team training time.

Dominic D’Agostino is a neuroscientist, a researcher in the fields of molecular pharmacology and physiology, and assistant professor at the University of South Florida. His research on the impact of ketogenic diets on cell metabolism, and their neuroprotective effects on oxygen toxicity, is supported by the Office of Naval Research, US Department of Defense, and the Alzheimer’s Association. Dom is a member of the Aerospace Medical Association, the Undersea and Hyperbaric Medicine Society, the Society of Neuroscience, the American Physiological Society, and also serves on the Editorial Board for the Journal of Applied Physiology, and as a reviewer for several other scholarly publications. He is one of the world’s foremost experts on ketosis and ketogenic supplements such as MCT oil.   Why you should listen –     Robert comes on Bulletproof Radio, live from the Bulletproof Conference, to discuss his metabolic therapy research, how starvation can be beneficial for brain metabolism, how ketones and ketogenic diets can enhance performance, and the use of MCT oil and ketogenic supplements. Enjoy the show!

Dominic D’Agostino is a neuroscientist, a researcher in the fields of molecular pharmacology and physiology, and assistant professor at the University of South Florida. His research on the impact of ketogenic diets on cell metabolism, and their neuroprotective effects on oxygen toxicity, is supported by the Office of Naval Research, US Department of Defense, and the Alzheimer’s Association. Dom is a member of the Aerospace Medical Association, the Undersea and Hyperbaric Medicine Society, the Society of Neuroscience, the American Physiological Society, and also serves on the Editorial Board for the Journal of Applied Physiology, and as a reviewer for several other scholarly publications. He is one of the world’s foremost experts on ketosis and ketogenic supplements such as MCT oil.   Why you should listen –     Robert comes on Bulletproof Radio, live from the Bulletproof Conference, to discuss his metabolic therapy research, how starvation can be beneficial for brain metabolism, how ketones and ketogenic diets can enhance performance, and the use of MCT oil and ketogenic supplements. Enjoy the show!

Timothy Hewett, PhD Director, OSU Sports Health & Performance Institute Director of Research, OSU Sports Medicine Professor, Departments of Physiology & Cell Biology, Family Medicine, Orthopaedics and Biomedical Engineering Topics in This Podcast 1. Recent trends in ACL injury 2. How the NBA utilized Dr. Hewitt 3. Biomechanical casues of ACL injuries 4. Post injury factors 5. Screening for risk factors 6. The best exericers for reducing ACL injuries 7. Prevention and training... one in the same 8. When to starting training to prevent ACL injuries 9. Why education is the most important aspect of prevention 10. How soon is too soon to come back from an ACL injury 11. Why reinjuries happen 12. The emotional toll from an ACL injury 13. Information about the ACL Workshop:  www.regonline.com/2014aclworkshop   Education and Background B.A. Anthropology from the University of Cincinnati 1984 B.S. Biology the University of Cincinnati 1984 Ph.D. Department of Physiology and Biophysics, University of Cincinnati College of Medicine 1990 Postdoctoral Fellowship in Molecular Biology, Department of Pharmacology & Cell Biophysics, University of Cincinnati 1993 Experience & Interests As Director of Research, Dr. Hewett is responsible for the oversight and coordination of a multi-disciplinary research program, as well as the development of strategic OSU Sports Medicine priorities. Hewett joined Ohio State in 2010 from Cincinnati Children’s Hospital, where he served as director of the Sports Medicine Biodynamics Center. He is nationally recognized for his work in the area of knee injury prevention in female athletes. Hewett, who also serves as a tenured professor in Ohio State’s department of physiology and cell biology, completed a doctorate in physiology and biophysics from the University of Cincinnati College of Medicine, and has a post-doctoral fellowship in molecular biology. His research interests range from the molecular alteration of muscle contraction to the development of new methods for injury prevention and athletic development. Hewett is a member of the American Orthopaedic Society for Sports Medicine and the American College of Sports Medicine. He has more than 220 peer-reviewed publications, over 15,000 citations and an h-index of 70. He has authored a book and multiple book chapters. He is a permanent member of the National Institutes of Health MRS Study Section and is on the Editorial board for several medical journals. He is an international expert in the field of injury prevention, especially of ACL injuries. Dr. Hewett has received several prestigious awards, including the NCAA, Excellence in Research, Systematic Review and O’Donoghue Awards from the American Orthopedic Society for Sports Medicine, the Rose Excellence in Research Award from the American Physical Therapy Association, the Clint Thompson Award from the National Athletic Trainers Association and a Young Investigator’s Award from the American Heart Association. He has been a Keynote speaker at many national and international conferences. His work has been cited on hundreds of occasions in lay press journals, including over ten in The New York Times, as well as Wall Street Journal, USA Today, Fox News, NPR and CBS. Dr. Hewett is a member of the American Orthopedic Society for Sports Medicine, The Orthopaedic Research Society and The American Physiological Society and is a Fellow in the American College of Sports Medicine.   Advising Narrative I am a Professor in the Departments of Physiology and Cell Biology, Orthopaedic Surgery, Family Medicine and Biomedical Engineering, as well as the School of Health and Rehabilitation Sciences at The Ohio State University. I have a doctorate in Physiology and Biophysics and post-doctoral fellowships in Molecular Biology and Biomechanics. I am an international leading expert in the field of injury prevention, with a special focus on ACL risk factor and prevention research. Thus far I have published over 220 peer-reviewed articles with over 15,000 citations in the medical literature, an h-index over 65 and have also authored a book and several book chapters. A permanent member of the National Institutes of Health MRS Study Section, I also serve on the Editorial board for several medical journals. My awards include the NCAA, Excellence in Research, Systematic Review and O’Donoghue Awards from the American Orthopedic Society for Sports Medicine, the Rose Excellence in Research Award from the American Physical Therapy Association, the Clint Thompson Award from the National Athletic Trainers Association and a Young Investigator’s Award from the American Heart Association. My work has been cited on hundreds of occasions in lay press journals, including over ten in The New York Times, as well as Wall Street Journal, USA Today, Fox News, NPR and CBS. My professional memberships include the American Orthopedic Society for Sports Medicine, The Orthopaedic Research Society and The American Physiological Society and I am a Fellow in the American College of Sports Medicine.   Books American Orthopaedic Society for Sports Medicine. Understanding and Preventing Non-Contact ACL Injury. Champagne, IL: Human Kinetics, January 2007.   12th Annual ACL WorkshopState of the Art Prevention and Rehabilitation Program Saturday, October 11, 2014from 8 am - 5:30 pmMedical Education andResource Center (MERC)*619 Oak StreetCincinnati, OH 45229Maps and directions maybe downloaded fromwww.cincinnatichildrens.org*This is NOT held at the Main Hospital. This workshop is designed for physicians, athletic trainers, physician assistants, nurses, occupational or physical therapists, students, researchers, strength and conditioning specialists, sports medicine and orthopedic health care professionals.The ACL workshop is a day dedicated to the prevention, training, and rehabilitation of athletes who are at risk for ACL injuries. The world renowned team at the Human Performance Laboratory in the Sports Medicine Biodynamics Center will detail the latest prevention programs for female athletes. We will utilize state-of-the-art 3D motion analysis to teach athlete screening techniques. We will also teach neuromuscular training methods that focus on proper core and knee control and landing techniques. www.elitefts.com    

Dr. Martin Frank is the Executive Director of the American Physiological Society. Prof. Michael Carroll is a Professor of Law and Director of the Program on Information Justice and Intellectual Property at the Washington College of Law at American University. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. M. Frank. Open but Not Free - Publishing in the 21st Century. N Engl J Med 2013;368:787-9. M. W. Carroll. Creative Commons and the Openness of Open Access. N Engl J Med 2013;368:789-91.

In this episode of Life Lines, we speak with Todd Kuiken, a doctor at the Rehabilitation Institute of Chicago and a professor at Northwestern University, about his efforts to develop a prosthetic arm that responds directly to signals from the brain. He will describe his latest research, which appears in the Journal of Neurophysiology, published by the American Physiological Society. This segment begins at 1:41.In our 'Ask a Physiologist' section, we'll talk to Ken Storey of Carleton University in Ottawa, Canada, who will answer the question 'Can an animal freeze, then thaw out and live?' This segment begins at 9:23.In our final segment, APS Executive Director Martin Frank will talk to Jim Hicks of the University of California at Irvine about the uniquely structured alligator heart and the role it plays in digestion. This final segment begins at 18:34. Photo Credit: Journal of Neurophysiology To read a summary of the prosthetics study in the Journal of Neurophysiology, please click here.