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8 episodes with deep brain stimulation dbs
4 episodes with deep brain stimulation dbs
2 episodes with deep brain stimulation dbs
2 episodes with deep brain stimulation dbs
2 episodes with deep brain stimulation dbs
5 episodes with deep brain stimulation dbs
2 episodes with deep brain stimulation dbs
4 episodes with deep brain stimulation dbs
Elektriciteit stroomt door ons lichaam. Elke beweging, emotie en beslissing wordt aangestuurd door elektrische impulsen in de hersenen. Luigi Galvani en zijn vrouw Lucia Galeazzi ontdekten samen voor het eerst elektriciteit vanuit het lichaam. We maken een sprong naar 250 jaar later. "Veel mensen realiseren zich niet dat het lichaam alleen maar kan werken dankzij elektriciteit,” zegt Damiaan Denys, filosoof en hoogleraar psychiatrie aan het Amsterdam UMC. Maar wat doet die stroom eigenlijk met ons? En kunnen we die inzetten in ons voordeel? In deze Focus aflevering duiken we diep in het brein: ⚡Damiaan Denys (https://www.damiaandenys.com/) onderzoekt Deep Brain Stimulation (DBS) en laat zien hoe gecontroleerde elektrische stroompjes gedrag kunnen beïnvloeden en zelfs depressie kunnen verlichten. “In tegenstelling tot andere therapieën, zag je mensen eigenlijk in een milliseconde verbeteren.”
Deep Brain Stimulation (DBS) is a ground-breaking technique that uses electrical impulses to treat conditions like epilepsy and depression through electrodes implanted in the brain. In this episode we are joined by Dr. Saurabh Sonkusare to learn about how DBS works and how it can be used in psychiatry and research. Ava and Beth discuss how DBS research findings may have implications for philosophical ideas of the self.
In this episode, we have the privilege of speaking with Dr. Todd Herrington, a leading neurologist and director of the Deep Brain Stimulation (DBS) program at Massachusetts General Hospital. Dr. Herrington specializes in movement disorders such as Parkinson's disease, tremor, and dystonia, and his research focuses on the motor, cognitive, and psychiatric effects of DBS, leveraging intraoperative and noninvasive neurophysiology and neuroimaging to advance neuromodulation therapies.Today, we'll explore his key role in the ADAPT PD trial, a groundbreaking multicenter study evaluating the safety and efficacy of adaptive DBS for Parkinson's disease. This trial, led by Dr. Helen Brontë-Stewart at Stanford, introduced a neurostimulator capable of sensing local field potentials and dynamically adjusting stimulation in real time based on a patient's brain activity. We'll discuss how this technology represents a shift toward personalized DBS therapy and what it means for the future of neuromodulation.In the second part of our conversation, we'll delve into broader topics, including the mechanism of action of DBS, novel neuromodulation approaches, and the potential role of stem cell therapy in movement disorders. Dr. Herrington shares his expert insights on how these advancements shape both our scientific understanding and the clinical application of DBS. From improving motor and non-motor symptoms in Parkinson's disease to pioneering adaptive neurostimulation, his work is at the forefront of innovation in the field.
Click here to subscribe for our podcast and video content on YouTube. In this episode of the Parkinson's Podcast, hear from John Dean, a speech language pathologist who exclusively works with people with Parkinson's, about the impacts that Deep Brain Stimulation can have on speech and swallowing. For more information about the Davis Phinney Foundation visit: https://dpf.org Season 6 Episode 3
Making the decision to have DBS surgery is not easy. But I didn't think it would be for the reason I discuss.#parkinsons #podcast #deepbrainstimulation #dbs #yopd #parkinsonssymptoms #thesecretlifeofpd #movementdisorder #pdAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
In movement disorders such as Parkinson's disease, essential tremor, and dystonia, normal function can be restored to the circuitry of the brain, resulting in significant improvement in function and quality of life. The goal of deep brain stimulation surgery is to modulate the activity of a specific brain region.In DBS, thin electrodes are placed in the disruptive areas of the brain and small electrical pulses normalize or eliminate the irregular signals. DBS is the non-permanent suppression of overactivity in the autopilot structure of the brain called the basal ganglia.Like a pacemaker for the brain, the battery (pulse generator) is implanted under the skin of the chest, and leads (wires) are tunneled under the skin via the deep part of the brain through a quarter-sized opening in the skull. The system is fully implanted under the skin, so there are no external wires or devices. The stimulator is fully programmable and therefore adjustable over time, as the disease changes. Patients can use a simple hand-held device to turn the DBS on or off, and adjust various other parameters if needed.
Supported by Abbott. Podcast Summary: Overview of DBS for Parkinson's Disease In this episode, we discuss Deep Brain Stimulation (DBS), a therapy used for over 20 years to manage Parkinson's symptoms when medications aren't enough. DBS involves surgically implanting electrodes in the brain, connected to a battery pack in the chest, to improve motor symptoms and normalize brain activity. Patient Stories: Ed McQuaid, diagnosed in 2018, had DBS in 2023. He went from taking 8-10 pills daily to none, regaining independence in activities like dressing and playing golf. Margaret Burns-Kohn, diagnosed in 2015, also had DBS in 2023. She eliminated severe dyskinesia and regained the ability to perform daily tasks like tying shoelaces. Abbott Liberta RC System Features: Dr. Mitesh Lotia Smallest rechargeable battery Wireless charging, just 15 minutes a week Remote programming and precise stimulation with directional leads Key Points: DBS isn't just for advanced Parkinson's—earlier intervention can help. Surgery doesn't limit physical activities, and most find it less daunting than expected. Next Steps: Visit lifewithdbs.com to connect with patient ambassadors. If interested, discuss DBS with your neurologist and consider scheduling an evaluation. Full benefits are typically seen 4-6 months post-surgery. Learn more about your ad choices. Visit megaphone.fm/adchoices
Have you ever wondered how it feels to flip a switch and instantly cure severe depression? Depression affects millions, often silently destroying lives due to stigma and misunderstanding. In this episode, discover a groundbreaking treatment that offers hope, learn why societal attitudes toward mental illness are deadly, and gain practical insights on supporting those struggling with depression. Listen now to hear Jon Nelson's incredible journey from suicidal despair to remission through deep brain stimulation, and learn how you can help save lives by changing your perspective on mental illness. Topics Discussed: The stigma and misunderstanding surrounding mental illness Deep Brain Stimulation (DBS) as a treatment for depression The physical and emotional toll of living with depression Societal norms that prevent men from seeking help Various treatments Jon tried before DBS The immediate impact of DBS on Jon's depression The concept of "abolition" in depression The need for increased funding and research in mental health Jon's advocacy work and "Pulverize the Stigma" initiative Chapters 00:00 Introduction and Life After Deep Brain Stimulation 05:01 The Experience of Living with Depression 09:25 The Societal Stigma of Mental Illness 13:01 The Roadblocks for Men Seeking Help 15:46 The Journey of Treatment and the Impact of Deep Brain Stimulation 22:20 The Fear of Recurrence and the Constant Battle 25:17 Accessibility and Affordability of Mental Illness Treatment 29:08 Advancements in Neurotechnology and the Future of Mental Health 31:08 Pulverize the Stigma: Jon Nelson's Advocacy Movement ---- GUEST WEBSITE: https://pulverizethestigma.com/ Follow Jon Nelson: https://www.linkedin.com/in/jon-nelson-95749837/ ---- MORE FROM THE FIT MESS: Connect with us on Threads, Twitter, Instagram, Facebook, and Tiktok Subscribe to The Fit Mess on Youtube Join our community in the Fit Mess Facebook group ---- LINKS TO OUR PARTNERS: Take control of how you'd like to feel with Apollo Neuro Explore the many benefits of cold therapy for your body with Nurecover Muse's Brain Sensing Headbands Improve Your Meditation Practice. Get started as a Certified Professional Life Coach! Get a Free One Year Supply of AG1 Vitamin D3+K2, 5 Travel Packs Revamp your life with Bulletproof Coffee You Need a Budget helps you quickly get out of debt, and save money faster! Start your own podcast!
What are the stigmas and stereotypes attached to cerebral palsy? What is daily life with dystonia like? What is cerebral palsy and how does it develop?In this podcast, Thomas Henley talks to Emma Stone, a cerebral palsy advocate (dystonia) and decorated horseriding athlete, currently studying a variety of Work Preparation modules in college and working in a local cafe.Within this podcast, Emma aims to dispell stigma and stereotypes around cerebral palsy and bring more awareness to them and share the more intimate negative experiences they've gone through in daily life, school, physio, surgery and healthcare. She also highlights the life lessons she's picked up and details her top tips for other individuals with cerebral palsy.Thomas's Links: https://linktr.ee/thomashenleyUKEmma's Blog: https://estoneblogersa.blogspot.com/?m=1Chapters: 00:00 - 01:24 Introduction01:24 - 05:09 Surgery and Deep Brain Stimulation (DBS)05:09 - 08:24 Who Is Emma Stone?08:24 - 10:55 What Is Cerebral Palsy?10:55 - 14:19 Developing Cerebral Palsy14:19 - 21:27 Living With Dystonia21:27 - 32:36 Escaping Isolation With Cerebral Palsy32:36 - 37:02 Navigating Healthcare with CP37:02 - 39:38 Horse riding Achievements39:38 - 46:45 Tips for Living With Cerebral Palsy46:45 - 49:08 Identity vs Person first language49:08 - 56:05 Stigma and Stereotypes56:05 - 01:02:56 Final ThoughtsSong Of The Day (Listen Here) - https://open.spotify.com/playlist/5UDIyN5TSYN4zMcRoQPrG8?si=9255ed3480d840b5Subscribe to the channel to get notified when I next go live
From levodora to Deep Brain Stimulation (DBS) we're all pretty familiar with the treatments for Parkinson's. But could there be something, just around the corner, that could change the whole game, not just stalling but reversing the tide of symptoms? That's the subject the Movers and Shakers are discussing today as they gather in the Notting Hill pub with special guest Professor Roger Barker, a world-leading expert on the application of stem cells as a potentially revolutionary treatment for Parkinson's. Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Additional production by Ewan Cameron.Music by Alex Stobbs.Artwork by Till Lukat.PR by Sally Jones.For more additional information about the show, as well as extra resources and exclusive content, please visit MOVERSANDSHAKERSPODCAST.COM Hosted on Acast. See acast.com/privacy for more information.
This week on sMater, Mater Private Hospital Townsville Neurologist Dr Craig Costello discusses supporting Parkinson's patients through Deep Brain Stimulation (DBS). Dr Costello outlines the DBS process and potential outcomes.To learn more about Mater, visit mater.org.au.
It's no surprise that medical treatments have advanced over the last 100 – or even 50 years. It's incredible what we are able to accomplish now! We're here with Dr. Ryder Gwinn and Idil Baysal from EvergreenHealth Neurosurgery, part of the Eastside Neuroscience Institute, to discuss an advanced neurosurgical procedure called Deep Brain Stimulation (DBS).
Before season three starts next month, we wanted to bring you an update on the marvellous brain of Paul Mayhew-Archer, which is now partially electrified. At the end of last year, Paul underwent Deep Brain Stimulation (DBS) a procedure that Gillian has previously undergone. Now, at the start of 2024, he's had the electrodes switched on. So what impact is the DBS having on Paul? How optimistic does he feel for the future? And what do the other Movers and Shakers make of a procedure that involves drilling into your head?Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Music by Alex Stobbs.Artwork by Till Lukat.PR by Sally Jones.Movers and Shakers is generously sponsored by Boardwave, high powered Executive networking programme for European Software CEO, Non-Exec Directors, Chairs and their Investors. They are keen supporters of Cure Parkinson's. To find out more, visit https://cureparkinsons.org.uk/ Hosted on Acast. See acast.com/privacy for more information.
In the latest episode of "When Life Gives You Parkinson's," Larry Gifford shares insights into his Deep Brain Stimulation (DBS) journey alongside his partner, Rebecca Gifford. Larry expresses excitement about the positive impact of DBS on his symptoms, noting improvements in walking, voice, and overall confidence. He recommends Dr. Jon Stamford's new DBS DIARY for a comprehensive view of the DBS dilemma. The episode features an interview with Brian Pepin, CEO of Rune Labs, the technological interface for Medtronic's DBS system. For those considering DBS, Larry invites questions through the show notes or via email. The podcast, a production of Curiouscast, is sponsored by PD Avengers, urging listeners to participate in SparktheNight.org and share the podcast for Parkinson's awareness. The episode concludes with a reminder to stay positive, exercise, and keep listening until the next installment.
Deep Brain Stimulation (DBS) is a highly effective and reasonably safe treatment for Parkinson's; however, it's also frequently misunderstood by people who have been recently diagnosed. The success stories about how people are sometimes living symptom and medication-free as a result of getting DBS understandably lead many who've been newly diagnosed to want to get the treatment as soon as possible. In an earlier webinar, we invited an esteemed panel of experts to talk about Deep Brain Stimulation (DBS). You can do so here if you haven't watched that session yet. In this episode of the Parkinson's Podcast, we spoke with six people with Parkinson's who've had DBS. We discussed: How to begin the process How to talk to your family and friends about DBS and your hopes and concerns about it What to expect during the approval process What the surgery is really like (and do you have to shave your head) What recovery is like and what kind of support you might need The challenges of programming your device and the joy that comes when you get it right The myths, challenges, and victories of DBS And more! We hope you enjoy it! Want to read the article associated with this podcast? Check it out on our website! Want to watch the video version of this podcast? You can watch it on our YouTube! Are you loving the Parkinson's Podcast? You can listen to more episodes on our website! Want to learn more about Deep Brain Stimulation? Check out our DBS Hub here! This content is made possible by the generous support of listeners like you. If you would like to make a donation, please visit: https://dpf.org/podcastdonation
In this episode of "When Life Gives You Parkinson's," Larry and Rebecca dive into Larry's recent Deep Brain Stimulation (DBS) surgery. It's the culmination of their DBS series, showcasing moments before and after the procedure. (Episode six of our 2023 DBS series) Larry shares his experiences, from the anticipation of the surgery to post-surgery reflections. He describes the fears he had about the head frame and the surgical process itself, emphasizing the involvement of Nurse Nancy and Dr. Honey. The detailed account covers the electrode installation, the testing of potential targets for relief, and the moments of consciousness during the surgery. Post-surgery, Larry discusses the "Honeymoon" period, a phase of initial relief and remarkable changes. He talks about the reduction in medication intake, improved bodily functions, and sensory experiences like regaining his sense of smell. Despite these positive changes, he notes signs of needing to gradually reintroduce medication as he experiences disorientation and fatigue. Larry and Rebecca conclude with observations of minor personality changes and a heartfelt conversation about what comes next. It's a personal, insightful episode that offers a firsthand account of the realities and changes that come with DBS surgery for Parkinson's Disease. MAIL Larry and Rebecca: ParkinsonsPod@curiouscast.ca Have a topic or questions that you would like Larry & Rebecca to address on a future episode? We would love you to click here and leave a message https://www.speakpipe.com/WhenLifeGivesYouParkinsons Follow us, Larry & Rebecca Gifford Facebook: Facebook.com/ParkinsonsPod Instagram: @parkinsonspod Twitter: @ParkinsonsPod Thanks to Curiouscast Our Presenting Partner is Parkinson Canada. Diagnosed with Parkinson's? You are not alone. Contact presenting partner Parkinson Canada http://www.parkinson.ca/, call the toll free hotline 1-800-565-3000 or on Twitter you can message @ParkinsonCanada. Additional thanks to... PD Avengers – We are building a global alliance to end Parkinson's. Join us.
As listeners to Movers and Shakers over the past year will know, Paul Mayhew-Archer has been on the waiting list for Deep Brain Stimulation (DBS) surgery. Finally, the time has come for Paul to head to the John Radcliffe hospital in Oxford, to have a touch of brain surgery. But will it all run smoothly? This is the first part of what we hope will be a two-part audio diary, as Paul prepares for the operation and faces up to the challenges and uncertainties that surround it. Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Music by Alex Stobbs.Artwork by Till Lukat.PR by Sally Jones.Movers and Shakers is generously sponsored by Boardwave, high powered Executive networking programme for European Software CEO, Non-Exec Directors, Chairs and their Investors. They are keen supporters of Cure Parkinson's. To find out more, visit https://cureparkinsons.org.uk/ Hosted on Acast. See acast.com/privacy for more information.
In movement disorders such as Parkinson's disease, essential tremor, and dystonia, normal function can be restored to the circuitry of the brain, resulting in significant improvement in function and quality of life. The goal of deep brain stimulation surgery is to modulate the activity of a specific brain region.In DBS, thin electrodes are placed in the disruptive areas of the brain and small electrical pulses normalize or eliminate the irregular signals. DBS is the non-permanent suppression of overactivity in the autopilot structure of the brain called the basal ganglia.Like a pacemaker for the brain, the battery (pulse generator) is implanted under the skin of the chest, and leads (wires) are tunneled under the skin via the deep part of the brain through a quarter-sized opening in the skull. The system is fully implanted under the skin, so there are no external wires or devices. The stimulator is fully programmable and therefore adjustable over time, as the disease changes. Patients can use a simple hand-held device to turn the DBS on or off, and adjust various other parameters if needed.
Listen to me gracefully ramble about my neurological struggles and what's to come. I'm hoping it will allow my audience to connect with me on a deeper level. ____________________________________________________ "Dystonia is a neurological hyperkinetic movement disorder in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures. The movements may resemble a tremor." Dystonia is not caused by stress or anxiety. There is very little awareness around Dystonia and there is no cure. Some patients are so disabled that they end up wheelchair-bound. Many Dystonia patients have social anxiety due to shame around the physical symptoms and some even have thoughts of suicide. The only current treatments are medications and Botox injections. Management therapies like physical therapy, massage, exercise, or counseling may slightly reduce symptoms in some patients, but not all. Deep Brain Stimulation (DBS) surgery is available only to approved Dystonia patients and reduces symptoms by 30-80% on average. Most Dystonia patients have tried numerous treatments without success and are left to suffer with the disabling effects. You bring more awareness to Dystonia just by listening to this episode and we thank you for that. ____________________________________________________ More resources and how to work with me here: https://linktr.ee/nerveboss --- Support this podcast: https://podcasters.spotify.com/pod/show/nerveboss/support
The fellas are joined once again by their friend and Parkinson's advocate, Larry Gifford. The gang have an intimate conversation about his life with Parkinson's, they delve into the heart of his upcoming Deep Brain Stimulation (DBS) surgery, a groundbreaking procedure aimed at reclaiming his quality of life. Larry's candor shines through as he describes the incredible journey he's undertaken. He opens up about the daily challenges of living with Parkinson's, shedding light on the disease's relentless grasp on his life. With unwavering resilience, Larry shares his excitement, anxiety, and hope as he prepares for the life-altering surgery, revealing the astonishing detail: "They will be drilling holes in my head to insert electrodes." The conversation takes a fascinating turn as Larry elaborates on the science behind DBS surgery, describing how he will soon wield a remote control to fine-tune the electric stimulus that will significantly improve his symptoms. The future is here. Good luck tomorrow Lar, we love you buddy! Join the post-episode conversation over on Discord! https://discord.gg/expeUDN
The fellas are joined once again by their friend and Parkinson's advocate, Larry Gifford. The gang have an intimate conversation about his life with Parkinson's, they delve into the heart of his upcoming Deep Brain Stimulation (DBS) surgery, a groundbreaking procedure aimed at reclaiming his quality of life. Larry's candor shines through as he describes the incredible journey he's undertaken. He opens up about the daily challenges of living with Parkinson's, shedding light on the disease's relentless grasp on his life. With unwavering resilience, Larry shares his excitement, anxiety, and hope as he prepares for the life-altering surgery, revealing the astonishing detail: "They will be drilling holes in my head to insert electrodes." The conversation takes a fascinating turn as Larry elaborates on the science behind DBS surgery, describing how he will soon wield a remote control to fine-tune the electric stimulus that will significantly improve his symptoms. The future is here. Good luck tomorrow Lar, we love you buddy! Join the post-episode conversation over on Discord! https://discord.gg/expeUDN
Season 6, Episode 6 SHOW NOTES Oct 17, 2023 TITLE: DBS Pre-Op Talks: Love and Transition Podcast Notes: In the latest episode of the When Life Gives You Parkinson's podcast, hosts Larry and Rebecca Gifford discuss the upcoming Deep Brain Stimulation (DBS) surgery. The surgery is scheduled for October 24th, 2023, at UBC Hospital in Vancouver, British Columbia, Canada. Larry and Rebecca take the audience through their preparations, discussions, and feelings as the surgery date approaches. They touch on a wide range of topics, including their emotional and practical preparations, managing their son Henry's needs, and the changes in household responsibilities. They also discuss the potential outcomes of the surgery and what they hope to achieve. They emphasize the importance of quality-of-life improvements and share their gratitude and love for each other. MAIL Larry and Rebecca: ParkinsonsPod@curiouscast.ca Have a topic or questions that you would like Larry & Rebecca to address on a future episode? We would love you to click here and leave a message https://www.speakpipe.com/WhenLifeGivesYouParkinsons Follow us, Larry & Rebecca Gifford Facebook: Facebook.com/ParkinsonsPod Instagram: @parkinsonspod Twitter: @ParkinsonsPod Thanks to Curiouscast Dila Velazquez – Story Producer Greg Schott – Sound Design Our Presenting Partner is Parkinson Canada. Diagnosed with Parkinson's? You are not alone. Contact presenting partner Parkinson Canada http://www.parkinson.ca/, call the toll free hotline 1-800-565-3000 or on Twitter you can message @ParkinsonCanada. Thanks also to PD Avengers – We are building a global alliance to end Parkinson's. Join us.
In this episode, Roz gives us an update on her DBS journey. We always hear the success stories, and while hers is still a success, she's encountered a few bumps along the way. Listen to her current struggles and how she's working to overcome them.
This episode is a feel good, inspirational story about the decision to have Deep Brain Stimulation (DBS) surgery. Basically, it's brain surgery and a major decision. I have the privilege of knowing my guest today and have followed her decision-making process and outcomes. As we know, every person with Parkinson's is different. However, the decision process will mostly be similar. We focus on that as well as her circumstances and outcomes. This episode is for everyone – people thinking about getting DBS, people who haven't heard about it and their family and friends. https://www.dbsandme.com/en.html
In this episode of "When Life Gives You Parkinson's," Larry Gifford and Rebecca Gifford delve into the world of Deep Brain Stimulation (DBS), continuing their 2023 series on this treatment option. While sharing their optimism about Larry's upcoming DBS surgery, they also address the importance of discussing the risks associated with it. They present real stories from individuals who've undergone DBS, shedding light on the complexities and varied experiences associated with this treatment. Kim Cornelis shares her personal journey, highlighting both the potential benefits and challenges of DBS. The episode also explores alternative treatments, like light therapy, and emphasizes the significance of open communication about the emotional and psychological impact of DBS, including discussions about suicidal ideation. Join Larry and Rebecca as they provide valuable insights and a balanced perspective on the choices facing individuals with Parkinson's disease. They emphasize the importance of well-informed decisions, emotional support, and understanding within the Parkinson's community. The podcast aims to raise awareness about the mental health aspects of living with Parkinson's and undergoing treatment. If you have no one to talk to about your suicidal thoughts, call your country's suicide hotline. INTERNATIONAL SUICIDE HOTLINES In Canada, it's 1-833-456-4566. In the U.S. Dial 988. In Australia, 131-114. And in the UK dial 0800 689 5652. KEY LINKS Thank You to: Kim Cornelis, PwP, Portland, Oregon Becca Miller, PhD, PwP Parkinson's Resources of Oregon Dr. Wayne Markman, founder & CEO of Symbyx Biome If you have no one to talk to about your suicidal thoughts, call your country's suicide hotline. INTERNATIONAL SUICIDE HOTLINES In Canada, it's 1-833-456-4566. In the U.S. Dial 988. In Australia, 131-114. And in the UK dial 0800 689 5652. MAIL Larry and Rebecca: ParkinsonsPod@curiouscast.ca Have a topic or questions that you would like Larry & Rebecca to address on a future episode? We would love you to click here and leave a message https://www.speakpipe.com/WhenLifeGivesYouParkinsons Follow us, Larry & Rebecca Gifford Twitter: @ParkinsonsPod Facebook: Facebook.com/ParkinsonsPod Instagram: @parkinsonspod Thanks to Curiouscast Dila Velazquez – Story Producer Greg Schott – Sound Design Our Presenting Partner is Parkinson Canada. Diagnosed with Parkinson's? You are not alone. Contact presenting partner Parkinson Canada http://www.parkinson.ca/, call the toll free hotline 1-800-565-3000 or on Twitter you can message @ParkinsonCanada. Thanks also to PD Avengers – We are building a global alliance to end Parkinson's. Join us.
Join us for an exclusive interview with a Parkinson's Disease (PD) patient living in Canada who underwent Deep Brain Stimulation (DBS) surgery. Our guest shares her personal experiences and unique insights into the DBS process, shedding light on how it differs between Canada and the United States.
In this episode of "When Life Gives You Parkinson's," Larry and Rebecca dive into Larry's upcoming Deep Brain Stimulation (DBS) surgery. They introduce Dr. Chris Honey, the neurosurgeon who will perform the procedure the brain surgeon. Dr. Honey breaks down what to expect and the possible risks of DBS, stressing the importance of picking the right surgeon and keeping a positive mindset. After the surgery, the plan is to use the DBS device to replicate Larry's best moments on medication, with the hope of eventually cutting down or even ditching the meds. The episode also brings in Tim Hague Sr., who shares his experience with the medication challenge, underlining just how much Levodopa (medication) can make a world of difference for folks dealing with Parkinson's. The podcast wraps up with a chat about making essential medications accessible worldwide and some cool facts about DBS. Check out these videos of Larry's OFF CHALLENGE My Eye Opening DBS "Off Challenge" https://youtu.be/GrlCmrHbtb0?si=PGRaESoYWMt4L5Uc The Power of Levodopa https://youtu.be/Mg91r2hT6p4?si=xFgVhnCSiRX8haLZ Thank You to: Neurosurgeon Dr. Christopher Honey www.DrHoney.com Nurse Nancy at the Vancouver Coastal Health DBS Clinic Tim Hauge Sr. www.TimSr.ca founder of www.uturnparkinsons.org www.pdavengers.com TV Show House Heel & Toe Films Shore Z Productions Bad Hat Harry Productions Moratim Produktions NBC Universal Television (2004-2007) Universal Media Studios (UMS) (2007) The Brain Surgeon - That Mitchell & Webb Look , Series 3 - BBC Two MAIL Larry and Rebecca: ParkinsonsPod@curiouscast.ca Have a topic or questions that you would like Larry & Rebecca to address on a future episode? We would love you to click here and leave a message https://www.speakpipe.com/WhenLifeGivesYouParkinsons Follow us, Larry & Rebecca Gifford Facebook: Facebook.com/ParkinsonsPod Instagram: @parkinsonspod Twitter: @ParkinsonsPod Thanks to Curiouscast Dila Velazquez – Story Producer Greg Schott – Sound Design Our Presenting Partner is Parkinson Canada. Diagnosed with Parkinson's? You are not alone. Contact presenting partner Parkinson Canada http://www.parkinson.ca/, call the toll free hotline 1-800-565-3000 or on Twitter you can message @ParkinsonCanada. Thanks also to PD Avengers – We are building a global alliance to end Parkinson's. Join us.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.17.549294v1?rss=1 Authors: Fahimi Hnazaee, M., Sure, M., O'Neill, G., Leogrande, G., Schnitzler, A., Florin, E., Litvak, V. Abstract: The combination of subcortical Local Field Potential (LFP) recordings and stimulation with Magnetoencephalography (MEG) in Deep Brain Stimulation (DBS) patients enables the investigation of cortico-subcortical communication patterns and provides insights into DBS mechanisms. Until now, these recordings have been carried out in post-surgical patients with externalised leads. However, a new generation of telemetric stimulators makes it possible to record and stream LFP data in chronically implanted patients. Nevertheless, whether such streaming can be combined with MEG has not been tested. In the present study, we tested the most commonly implanted telemetric stimulator - Medtronic Percept PC with a phantom in three different MEG systems: two cryogenic scanners (CTF and MEGIN) and an experimental Optically Pumped Magnetometry (OPM)-based system. We found that when used in combination with the new SenSight segmented leads, Percept PC telemetric streaming only generates band-limited interference in the MEG at 123Hz and harmonics. However, the 'legacy streaming mode' used with older lead models generates multiple, dense artefact peaks in the physiological range of interest (below 50Hz). The effect of stimulation on MEG critically depends on whether it is done in bipolar (between two contacts on the lead) or monopolar (between a lead contact and the stimulator case) mode. Monopolar DBS creates severe interference in the MEG as previously reported. However, we found that the OPM system is more resilient to this interference and could provide artefact-free measurements, at least for limited frequency ranges. A resting measurement in the MEGIN system from a Parkinson's patient implanted with Percept PC and subthalamic SenSight leads revealed artefact patterns consistent with our phantom recordings. Moreover, analysis of LFP-MEG coherence in this patient showed oscillatory coherent networks consistent in their frequency and topography with those described in published group studies done with externalised leads. In conclusion, Percept PC telemetric streaming with SenSight leads is compatible with MEG. Furthermore, OPM sensors could provide additional new opportunities for studying DBS effects. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
The Movers and Shakers are back in the Notting Hill pub, and this week they're joined by an illustrious guest. Professor Ludvic Zrinzo is a world renowned specialist in Deep Brain Stimulation (DBS) and, in her own words, the "only man to have been been inside [Gillian's] brain". DBS is an exciting but often misunderstood treatment in the world of Parkinson's care, and the gang are going to put Prof Zrinzo under the microscope. Who is right for DBS? Are there symptoms it won't help? And why are waiting lists so bloody long?Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn, and Jeremy Paxman.With Professor Ludvic Zrinzo.Produced and edited by Nick Hilton for Podot.Additional editing by Ewan Cameron.Additional production by Adrian Lacey. Music by Alex Stobbs.Artwork by Till Lukat.PR by Sally Jones.Movers and Shakers is generously sponsored by Boardwave, high powered Executive networking programme for European Software CEO, Non-Exec Directors, Chairs and their Investors. They are keen supporters of Cure Parkinson's. To find out more, visit https://cureparkinsons.org.uk/ Hosted on Acast. See acast.com/privacy for more information.
Balance Matters: A neuro physical therapist’s journey to make “Sense” of Balance
In this episode we will dive deeper into deep brain stimulation for Parkinson's, the role of the health team, patient self-advocacy and the importance of effective communication. Dr. Eric Rhoden's unique experience and expertise brings us new perspectives and ideas. Dr Eric. Rhoden was born and raised in San Diego, California, making Austin, Texas his home in 2016. Dr. Rhoden has always thrived on competition and learning new skills. After dabbling in many sports over the years, soccer became his primary focus. Just before playing soccer at the collegiate level, he sustained a knee injury, removing him from the sport and solidifying his desire to pursue a career in physical therapy. He graduated Magna Cum Laude with his bachelor's in Kinesiology from California State University, San Marcos and received his Doctorate of Physical Therapy from Loma Linda University. Following his academic accomplishments, Dr. Rhoden has served in various institutions and corporations as an advisor for health-related products, policies, and research projects. He has over 10 years experience in wellness coaching, nutrition, and personal training. During the past 6 years, Dr. Rhoden has been a movement disorder specialist with a local neurology practice. During the height of the pandemic, he co-founded a remote COVID-19 testing company to support the community. In addition, Dr. Rhoden has also spent time providing continuing education courses throughout the US on comprehensive Parkinson's care and enjoys presenting to local groups throughout the Austin area.References:Comparison of Globus Pallidus Interna and Subthalamic Nucleus in Deep Brain Stimulation for Parkinson Disease: An Institutional Experience and ReviewUpdate on Current Technologies for Deep Brain Stimulation in Parkinson's Disease - PMC (nih.gov)(PDF) Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease? (researchgate.net)Physical therapy and deep brain stimulation in Parkinson's Disease: protocol for a pilot randomized controlled trial - PubMed (nih.gov)Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review - PubMed (nih.gov)
In this episode, Heather Kennedy, a person with Parkinson's who has been living with the diagnosis for 12 years discusses: Three articles she's recently written called “Gifted”, “Poison for Breakfast”, and “Sweating it Out” Her journey with Deep Brain Stimulation (DBS) The difficulty of unpredictable ON and OFF times in Parkinson's and how those times impact relationships How her views have changed since the initial days of her diagnosis The difficulty of discerning between symptoms that are due to Parkinson's, medications, or something else entirely The burden of explaining Parkinson's to those who don't understand The importance of having compassion for people with Parkinson's and nurturing that compassion in all areas of life Visit the blog post for this episode here to find related resources, the video recording, and more.
The ABMP Podcast | Speaking With the Massage & Bodywork Profession
A massage therapist accidentally finds an electrical wire running down their client's neck, alongside their SCM—surprise! It turns out to be a deep brain stimulation (DBS) device to help treat Parkinson's disease. DBS can also be used to treat a handful of other conditions, and treating more conditions continues to be investigated. So the chance you could have a client with a DBS device is higher than ever. How do we do that safely? Listen to this episode of “I Have a Client Who . . . ” for more. Sponsors: Books of Discovery: www.booksofdiscovery.com Advanced-Trainings: www.advanced-trainings.com Host Bio: Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com. Recent Articles by Ruth: “Unpacking the Long Haul,” Massage & Bodywork magazine, January/February 2022, page 35, www.massageandbodyworkdigital.com/i/1439667-january-february-2022/36. “Chemotherapy-Induced Peripheral Neuropathy and Massage Therapy,” Massage & Bodywork magazine, September/October 2021, page 33, http://www.massageandbodyworkdigital.com/i/1402696-september-october-2021/34. “Pharmacology Basics for Massage Therapists,” Massage & Bodywork magazine, July/August 2021, page 32, www.massageandbodyworkdigital.com/i/1384577-july-august-2021/34. Resources: Pocket Pathology: https://www.abmp.com/abmp-pocket-pathology-app Image of Deep Brain Stimulation: https://commons.wikimedia.org/wiki/File:Deep_Brain_Stimulation.jpg Deep Brain Stimulation (2021). Available at: https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/deep-brain-stimulation (Accessed: 26 October 2022). Deep Brain Stimulation – Advantages, Risks and Conditions Treated (no date a). Available at: https://www.aans.org/ (Accessed: 25 October 2022). Deep Brain Stimulation (DBS) FAQ | Boston Scientific (no date) www.dbsandme.com. Available at: https://www.dbsandme.com/en/support-and-resources/faq.html (Accessed: 26 October 2022). Deep Brain Stimulation (DBS): What It Is, Purpose & Procedure (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/treatments/21088-deep-brain-stimulation (Accessed: 26 October 2022). Franchina, P. (2019) ‘Deep brain stimulation and swimming', American Parkinson Disease Association, 4 December. Available at: https://www.apdaparkinson.org/article/deep-brain-stimulation-and-swimming/ (Accessed: 26 October 2022). ‘Life after deep brain stimulation – eParkinsonPost' (no date). Available at: https://parkinsonpost.com/life-after-deep-brain-stimulation/ (Accessed: 26 October 2022). St. Joseph's Hospital and Medical Center, Phoenix (2022) Exercise in Advanced Parkinson's Disease (PD) With Deep Brain Stimulation (DBS). Clinical trial registration NCT05204680. clinicaltrials.gov. Available at: https://clinicaltrials.gov/ct2/show/NCT05204680 (Accessed: 25 October 2022). What you need to know about deep brain stimulation (DBS) | News (2020). Available at: https://news.llu.edu/patient-care/what-you-need-know-about-deep-brain-stimulation-dbs (Accessed: 26 October 2022). About our Sponsor: About Til Luchau and Advanced-Trainings.com: As a Certified Advanced Rolfer™, Til was on the faculty of the Dr. Ida Rolf Institute® for 20 years, where he served as Coordinator and Faculty Chair of the Foundations of Rolfing Structural Integration program. The author of the Advanced Myofascial Techniques textbook series (which has been translated into 6 languages), his regular Myofascial Techniques and Somatic Edge columns have been featured in Massage & Bodywork magazine since 2009, and (along with Whitney Lowe) he co-hosts the popular Thinking Practitioner Podcast. He is the Director of Advanced-Trainings.com which since 1985 has offered short, credit-approved professional trainings and certification for manual therapists of all types, in person and online. Website: Advanced-Trainings.com Email: info@advanced-trainings.com Facebook: facebook.com/Advanced.Trainings1/ Instagram: instagram.com/tilluchau YouTube: youtube.com/user/AdvancedTrainings
Deep Brain Stimulation (DBS), an exciting treatment option for people with Parkinson's Disease, Essential Tremor and Dystonia.We are the only center in Ventura County, and one of the few in Southern California to offer this treatment.While the selection process is thorough, we encourage anyone with one of these conditions to come in and discuss this option. Boiled down, when taking more pills is not the answer, come in and learn more. We expect to improve a patient's symptoms while at the same cutting meds in half--and sometimes more!
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Andre Mercanzini is the Co-Founder and Chief Technology Officer at Aleva Neurotherapeutics which has worked in directional Deep Brain Stimulation (DBS) device leads for Parkinson's and other diseases. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here*** Top 3 Takeaways: "We realized during that time that the intervention that could benefit the most from the miniaturization technologies was by far and away, deep brain stimulation." "MEMS allowed us to align every single electrode into its position, have it almost prewired and decrease the amount of touch time that an operator would have to spend on the device as they're manufacturing it, which, which gives us a price advantage as well." "My advice to PhD students postdocs, physician inventors, and professors working on neuro technologies is that you have to work on something that will make a major change in patient outcomes. It cannot just be incremental. If it has any signs of only being incremental, it will be very difficult to get funded. It will be very difficult to get your early adopters to sign up and use or test your device. It's always a difficult metric to determine what that means. Is it a 20% improvement in symptoms? Is it a 40% improvement in symptoms? Is it treating a disease that is not treatable today? That is really the major choice you have to make as an entrepreneur in your own technology is whether your work will make a significant change in patient outcomes." 0:30 "Do you want to explain what Aleva does a little bit and a little bit of your background?" 3:30 "What would you say that is a special thing in Lausanne that maybe other places could copy or are not able to copy?" 5:00 "Let's talk about Aleva" 6:45 "Iris Biomedical ad sponsorship" 7:15 "What's DBS and how did Aleva get started? You were saying this spun out of your PhD work. What did that look like then? And maybe how has it changed now?" 13:15 "Why is having directional leads was such a design problem?" 16:45 "What has the evolution been in the last decade, and then maybe what's future directions?" 20:30 You raised $70 million to get through the regulatory pathway, this seems like alot, couldn't you do it with 5 or 10 million? 23:30 Surgeons often like to stick with what they know, do you know if there would be a demand for what you are making? 25:45 Do you want to talk about wearables and how this fits in with your company? 29:00 "What advice do you have for people who want to follow in your footsteps and want to, create, raise $70 million and do you have to be in Switzerland to do this?" 31:45 "You've raised a lot of money and so is that good or bad and aren't you worried about being diluted too much?" 34:00 " Is there anything that we didn't talk about that you wanted to mention?"
The Secret Life of Parkinson's: In this episode, we check in with Brian who has gone through deep brain stimulation surgery: the right side in June, the left side in July, and the battery implant in August. We get a chance to talk to him about the ups and downs, right before his DBS equipment get's "turned on".
On episode #26 of The Secret Life of Parkinson's, Brian Baker shares more details about his journey with Deep Brain Stimulation (DBS) surgery. He walks us through how he made the decision, what it was like waiting in the hospital, how it felt while they were doing the procedure, and how he felt the days following. Brian goes in for his next surgery tomorrow (Friday) for the other side - good luck, Brian!
Khaled Moussawi MD, PHD, Assistant Professor of Psychiatry, is an experienced clinical neurologist and neuroscientist. This Podcast summarizes his research team's efforts to identify and translate pre-clinical neurobiological findings into actionable clinical treatment protocols for alcohol and potentially other addictions. Deep Brain Stimulation, DBS, now approved treatment of Parkinson's disease, holds such promise for patients with chronic severe alcohol use disorders.
Dr. Arif Dalvi joins Scott tonight to talk about Parkinson's and Alzheimer's diseases. From the latest developments in Deep Brain Stimulation (DBS) and MRI Focused Ultrasound to early diagnosis and treatment there is so much packed into this hour you'll want to listen more than once.
This show shares my interview with Neurosurgeon, Dr. Andrew Conner, from the University of Oklahoma Neurosurgery department. Dr. Conner received his DBS training from one of the top rated DBS centers in the world, the University of California San Francisco . In the last few years, the field of Movement Disorders have witnessed numerous advances in technology for Deep Brain Stimulation (DBS). Now there are three device companies producing innovative hardware for the market place. The surgical procedure has evolved with the technology and outcomes have improved greatly with these advances. We have seen not only better efficacy results from the procedure but a reduction in side effects. Dr. Conner shares the details of these advances and how he performs the surgery today. In addition, Dr. Conner provides great advise on caring for a loved one going through DBS surgery. He points out what to watch out for after surgery. Dr. Conner has a passion for this procedure and helping patients who require this DBS implant to have the best outcome possible. He also discusses some of the differences between the new Ultrasound ablation procedure as it compares to DBS. The Parkinson's disease Caring Podcast is produced and hosted by Dr. Kevin Klos. Please visit www.pdcaring.com for more resources and information.
Machine Medicine Interview Series hosted by Dr Jonathan O'Keeffe with Dr Ro'ee Gilron This episode is about adaptive neuromodulation and more specifically on Deep Brain Stimulation (DBS) for treating Parkinson's disease (PD) patients. With smarter DBS, we can try and address some side effects or other PD symptoms that aren't now well-controlled. Transcript for interview highlight: https://machinemedicine.com/interview-series/adaptive-neuromodulation/ Find out more topics: https://machinemedicine.com/interview-series/ ————————————————————————————— Visit our website: https://machinemedicine.com/ Connect with us on LinkedIn: https://www.linkedin.com/company/machine-medicine/
April marks National Parkinson's Awareness Month and Dr. Joohi Jimenez-Shahed, MD, movement disorders neurologist at the Icahn School of Medicine at Mount Sinai in New York, and Jeff, who she treats for Parkinson's Disease (PD) discuss the latest technology surrounding deep brain stimulation (DBS) and how it can help improve or relieve movement symptoms of PD. They also talk about how to know if DBS is right for others with PD and the impact of the disease on those living with it. Dr. Shahed - After completing her undergraduate degree at Washington University in St. Louis, Dr. Shahed received her medical degree from Baylor College of Medicine (BCM) and Neurology residency training at Duke University Medical Center. She then completed a fellowship in Movement Disorders at the Parkinson's Disease Center and Movement Disorders Center (PDCMDC) at BCM. Her research interests lie in investigating the intraoperative neurophysiology of patients undergoing deep brain stimulation (DBS) for movement disorders and the application of wearables and digital health technologies to the care of patients with Parkinson's disease. Dr. Shahed serves as Chair of the Functional Neurosurgical Working Group of the Parkinson Study Group, Chair of the Science Advisory Board for the Davis Phinney Foundation for Parkinson's, member of the Medical Advisory Board of the Tourette Association of America and past chair of the Medical Advisory Board of the Houston Area Parkinson Society. She is the lead investigator for RAD-PD: a national quality improvement registry for patients undergoing DBS surgery for Parkinson's disease. She is also an investigator with the Huntington Study Group, Dystonia Coalition and TSA International Database of DBS Studies in Tourette syndrome. She has served as Principal Investigator for industry-sponsored and investigator-initiated clinical trials and has authored several papers and book chapters. She is the recipient of the Roy H. Cullen Quality of Life Award (Houston Area Parkinson Society), the Rising Start Clinician Award (BCM), the Fulbright & Jaworski L.L.P. Faculty Excellence Award in Teaching and Evaluation (BCM) and the Healthcare Heroes Award for Outstanding Health Care Practitioner (Houston Business Journal). She was recognized as a Woman of Excellence at BCM, and is a 2018 graduate of the inaugural Women Leading in Neurology program of the American Academy of Neurology. Jeff was diagnosed with Parkinson's Disease in July 2016 at the age of 64. He practiced dentistry in Long Island , NY for over 40 years prior to his diagnosis ,retiring shortly after. He spends his retirement golfing, caring for his young grandchildren, and working out with his friends at Rock Steady Boxing. Originally from Baltimore, MD Jeff attended Emory University in Atlanta where he met his wife Jan. #DeepBrainStimulation #DBS
Learn about how researchers built a “soft robot” that reached the depths of the Mariana Trench, the deepest part of the ocean; why musicians with brain tumors serenade their surgeons; and the best way to phrase words of comfort. A "soft robot" reached the deepest part of the ocean by Grant Currin Li, G., Chen, et al. (2021). Self-powered soft robot in the Mariana Trench. Nature, 591(7848), 66–71. https://doi.org/10.1038/s41586-020-03153-z Laschi, C., & Calisti, M. (2021). Soft robot reaches the deepest part of the ocean. Nature, 591(7848), 35–36. https://doi.org/10.1038/d41586-021-00489-y Musicians with Brain Tumors Serenade Their Surgeons by Ashley Hamer Haun, S. (2011, June 9). Roger Frisch Follow-Up Talk. String Visions | from Ovation Press. http://stringvisions.ovationpress.com/2011/06/roger-frisch-follow-up-talk/ Deep Brain Stimulation (DBS). (2019). Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/21088-deep-brain-stimulation Patient plays saxophone while surgeons remove brain tumor. (2017, August 30). EurekAlert! https://www.eurekalert.org/pub_releases/2017-08/uorm-pps083017.php Garcea, F. E., Chernoff, B. L., Diamond, B., Lewis, W., Sims, M. H., Tomlinson, S. B., Teghipco, A., Belkhir, R., Gannon, S. B., Erickson, S., Smith, S. O., Stone, J., Liu, L., Tollefson, T., Langfitt, J., Marvin, E., Pilcher, W. H., & Mahon, B. Z. (2017). Direct Electrical Stimulation in the Human Brain Disrupts Melody Processing. Current Biology, 27(17), 2684-2691.e7. https://doi.org/10.1016/j.cub.2017.07.051 Here's the best way to phrase words of comfort by Kelsey Donk Validation may be best way to support stressed out friends and family | Penn State University. (2020). Psu.edu. https://news.psu.edu/story/612979/2020/03/25/research/validation-may-be-best-way-support-stressed-out-friends-and-family Tian, X., Solomon, D. H., & Brisini, K. St. Cyr. (2020). How the Comforting Process Fails: Psychological Reactance to Support Messages. Journal of Communication, 70(1), 13–34. https://doi.org/10.1093/joc/jqz040 Follow Curiosity Daily to learn something new every day withCody Gough andAshley Hamer — for free! You can also listen to our podcast as part of your Alexa Flash Briefing; Amazon smart speakers users, click/tap “enable” here:https://www.amazon.com/Curiosity-com-Curiosity-Daily-from/dp/B07CP17DJY See omnystudio.com/listener for privacy information.
Brandon chats with Dr. Kathryn Holloway, Neurosurgeon with VCU Health, about Deep Brain Stimulation (DBS) surgery as an option to treat symptoms from Parkinson's Disease. Dr. Holloway discusses who is/isn't a great candidate for DBS, what the DBS surgery entails, safety with DBS, what to expect after DBS, and much more. Resources Mentioned VCU Parkinson's Disease Page VCU DBS Information Page Medtronic DBS Guide from Parkinson's Foundation Boston Scientific Abbott DBS Dr. Holloway's Contact Information Dr. Holloway's Biography on VCU Health Website For questions and feedback regarding this episode/request a topic please email us at brandonpoen@gmail.com InMotion Physical Therapy Company Website InMotion East End Facebook Page InMotion Facebook Page Clinic Information East End Clinic Address: 5711 S Laburnum Ave, Richmond, VA 23231 Phone: (804) 447-5355 West End Clinic Address: 3001 Hungary Spring Rd Suite d, Richmond, VA 23228 Phone: (804) 756-8490
“In many cases you can see an immediate effect, as in chronic depression – suddenly you turn on the electrodes – you don't tell them when it's on or off, right? And their whole face lights up. And you ask, "What do you feel like?" And they say, "Oh, it feels wonderful. It feels like I won the lottery! It's so great!" – Dr. Heather Berlin, Neuropsychologist and Assistant Clinical Professor at Mount Sinai Episode 14: "Psychedelics, Impulsivity, and Brain Stimulation" with Dr. Heather Berlin *On Consciousness* In this episode, our guest is neuropsychologist Dr. Heather Berlin, an Assistant Clinical Professor in Psychiatry at Mount Sinai School of Medicine. Dr. Berlin conducts research to better understand the neural basis of impulsivity, compulsivity, and emotion with the goal of more targeted treatment. She employs neuroimaging and neuropsychological and psychopharmacological testing of brain lesion and compulsive, impulsive, and personality disorder patients. She is also interested in the neural basis of consciousness, dynamic unconscious processes, the use of psychedelics to treat mental disorders, and in the neural basis of creativity. We discuss her work and interests in this episode. Talking Points: 0:00 – Introduction 3:09 – Impulse Control and Associated Brain Areas 9:27 – Finding a Balance: Healthy Brain vs Impairment and Self Regulation17:40 – The Essence of Obsessive-Compulsive Disorders24:40 – The Big News: Deep Brain Stimulation as an Effective Treatment for OCD29:29 – Brain Aspects of Stress and Resilience 37:01 – How Effective is Deep Brain Stimulation?41:59 – Advances in Psychedelic Research45:15 – Psilocybin and Ego Dissolution 54:18 – Pharmaceutical Addiction Tapering58:12 – Flow States, Mystical Experiences: “The Cosmic Perspective” 01:04:46 – Possibilities Summary: Dr. Berlin has done an enormous range of work, which you can distill into this very profound question: “How do we control our unwanted impulses, our desires, our emotions, our reactions with other people?” These are very common questions, starting very early in life.For example, imagine yourself as a child looking at the most delicious food, let’s use ice cream, and not being allowed to eat it… impulse control is having to wait. Impulse control is not just a problem in childhood, it is perhaps the major problem in adults who have significant psychological troubles. This includes the addictions, but also severe mood swings that adults want to change, but do not seem to have the power to change in these moments. When it is hard to control repeated impulses, we talk about compulsions; cigarette smoking can be seen as a compulsion. When repetitive thoughts are hard to regulate, we talk about obsessions. There seems to be a tug of war between those deep midbrain nuclei and the control system which involves the prefrontal cortex. Various areas of the prefrontal cortex have somewhat different effects, but prefrontal is associated with self regulation, while midbrain nuclei have to do with impulses, motivations, emotions, and so on. The prefrontal cortex is sometimes called the “organ of civilization” or as Heather dubs it, “the brake system”.The Big NewsIt is amazing how low level electrical stimulation by microscopic electrodes can profoundly change human mood disorders, like severe depression. The brain areas stimulated include the nucleus accumbens and ventral striatum of the basal ganglia, and local areas in the prefrontal cortex. “Medical science is often an art as well as a science, but Deep Brain Stimulation (DBS) really can have significant effect and impact on people with difficult-to-treat conditions, like OCD (Obsessive Compulsive Disorder), but also people with intractable or untreatable depression,” says Dr. Heather Berlin.DBS can be surprisingly effective. As Dr. Berlin points out, “DBS is a huge success story. 40 to 50% of patients with severe untreatable depression, and about 60 to 70% of patients with severe OCD all have significant improvement in people who’ve tried every first line treatment and nothing has worked. In many cases you can see an immediate effect, as in chronic depression -- suddenly you turn on the electrodes -- you don't tell them when it's on or off, right? And their whole face lights up. And you ask "What do you feel like?" And they say "Oh, it feels wonderful. It feels like I won the lottery! It's so great!" And as they're talking, you turn off the electrodes and you just see their whole affect drop right back down.” Surprising Advances in Psychedelic ResearchIn the 1960s, psychedelics got a mixed reception, because many people had spectacular experiences, but physicians often wondered if there were harmful side effects. Now we are seeing a return to psychedelics as a promising treatment for different neuropsychiatric conditions. The new therapies always combine the psychedelic-assisted treatment with the presence of a specialized psychotherapist. Dr. Berlin gives us a summary of the new discoveries in the use of psychedelics, including MDMA for the treatment of PTSD, psilocybin to treat anxiety and people with end of life issues, ketamine, a dissociative anesthetic, for the treatment of severe depression and particular suicidality, and more recently DMT (or ayahuasca) as a treatment for certain psychiatric illnesses. After 50 years of persistent efforts to find solutions, in the last decade we finally have treatments with dramatic positive effects. Dr. Heather Berlin presents us with recent medical breakthroughs for very severe life problems that have been difficult to address.Get a 40% Discount for your copy of Bernie Baars' acclaimed new book On Consciousness: Science & Subjectivity - Updated Works on Global Workspace TheoryGO TO: http://shop.thenautiluspress.comAPPLY DISCOUNT CODE AT CHECKOUT: "PODCASTVIP" Bios: Dr. Heather Berlin is a dual-trained neuroscientist and clinical psychologist, and assistant clinical professor of psychiatry at the Icahn School of Medicine at Mont Sinai in NY. She explores the neural basis of impulsive and compulsive psychiatric and neurological disorders with the aim of developing novel treatments. She is also interested in the brain basis of consciousness, dynamic unconscious processes, and creativity. Clinically, she specializes in lifespan (child, adolescent, and adult) treatment of anxiety, mood, and impulsive and compulsive disorders (e.g. OCD), blending her neural perspective with cognitive behavioral therapy, mindfulness, and humanistic approaches. You can visit her website at https://www.heatherberlin.com/ Bernard Baars is best known as the originator of global workspace theory and global workspace dynamics, a theory of human cognitive architecture, the cortex and consciousness. Bernie is a former Senior Fellow in Theoretical Neurobiology at the Neurosciences Institute in La Jolla, CA, and Editor in Chief of the Society for MindBrain Sciences. He is author of many scientific papers, articles, essays, chapters, and acclaimed books and textbooks. Bernie is the recipient of the 2019 Hermann von Helmholtz Life Contribution Award by the International Neural Network Society, which recognizes work in perception proven to be paradigm changing and long-lasting. He teaches science. It keeps him out of trouble.
In her third lecture, Zoghbi explores possible therapies for MECP2 disorders. First, using Deep Brain Stimulation (DBS), Zoghbi's team together with collaborator Dr. Jianrong Tang were able to rescue learning and memory deficits, enhance neurogenesis, correct abnormal neural network activity, and improve MeCP2-linked gene expression changes in a mouse model of Rett Syndrome. Then, she discusses two approaches to normalize the MeCP2 protein in MECP2 duplication mice: by deleting the duplicated MECP2 gene in the genome, or by decreasing MECP2 mRNA levels using antisense-oligonucleotides. Even though these two approaches seem to rescue developmental issues caused by MECP2 duplication, titrating MeCP2 levels is required in order to avoid Rett-like symptoms caused by lowering the protein too much.
In her third lecture, Zoghbi explores possible therapies for MECP2 disorders. First, using Deep Brain Stimulation (DBS), Zoghbi’s team together with collaborator Dr. Jianrong Tang were able to rescue learning and memory deficits, enhance neurogenesis, correct abnormal neural network activity, and improve MeCP2-linked gene expression changes in a mouse model of Rett Syndrome. Then, she discusses two approaches to normalize the MeCP2 protein in MECP2 duplication mice: by deleting the duplicated MECP2 gene in the genome, or by decreasing MECP2 mRNA levels using antisense-oligonucleotides. Even though these two approaches seem to rescue developmental issues caused by MECP2 duplication, titrating MeCP2 levels is required in order to avoid Rett-like symptoms caused by lowering the protein too much.
By Richard Hunt After a relatively new and very delicate surgical procedure for Parkinson’s disease, Bill Ragle says his wife has “got her husband back, for the time being at least.” The operation was to enable Deep Brain Stimulation (DBS), where small holes are drilled into his skull and electrodes are placed deep in his brain to provide a constant electrical charge. The results have been remarkable. Bill can once again strum a guitar and his voice is stronger. “I can walk normally. I’m actually playing tennis.” He explains it’s not a Parkinson’s cure, but a “reprieve.” This is not only a story of modern medicine, but of solid, trusting faith in God. We invite you to share in this journey.
By Richard Hunt After a relatively new and very delicate surgical procedure for Parkinson’s disease, Bill Ragle says his wife has “got her husband back, for the time being at least.” The operation was to enable Deep Brain Stimulation (DBS), where small holes are drilled into his skull and electrodes are placed deep in his brain to provide a constant electrical charge. The results have been remarkable. Bill can once again strum a guitar and his voice is stronger. “I can walk normally. I’m actually playing tennis.” He explains it’s not a Parkinson’s cure, but a “reprieve.” This is not only a story of modern medicine, but of solid, trusting faith in God. We invite you to share in this journey.
Leading off we talk with Omotola Thomas and Gavin Mogan about the 7 reasons video... http://gofundme.com/f/seven-reasons?utm_medium=copy_link... Next up we have the three stooges performing Deep Brain stimulation on my radio partner Mike Achin...yes you heard that right Next the 2 Mikes & Gail have a 40 minute DBS discussion with Dr. Okeanis Vaou…. Director of Movement Disorders and Deep Brain Stimulation (DBS) at St. Elizabeth's Medical Center We talked about: -Does DBS slow progression -Does DBS cause Dementia -When is the ideal time to consider DBS? -Dopamine Agonist Withdrawal Syndrome (DAWS) -The new Medtronic battery -And more
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.16.252957v1?rss=1 Authors: Mottaghi, S., Hofmann, U., Kohl, S., Biemann, D., Liebana, S., Montano, R., Wilson, M., Klaus, C., Uchenik, M., Buchholz, O., Schmidt, R. Abstract: Cortico-basal ganglia beta oscillations (13-30Hz) are assumed to be involved in motor impairments in Parkinson Disease (PD), especially in bradykinesia and rigidity. Various studies have utilized the unilateral 6-OHDA rat PD model to further investigate PD and test novel treatments. However, a detailed behavioral and electrophysiological characterization of the model, including analyses of popular PD treatments such as DBS, has not been documented in the literature. We hence challenged the 6-OHDA rat PD model with a series of experiments (i.e. cylinder test, open field test and rotarod test) aimed at assessing the motor impairments, analyzing the effects of Deep Brain Stimulation (DBS), and identifying under which conditions excessive beta oscillations occur. We found that hemi-PD rats presented an impaired performance in all experiments compared to the sham group, and DBS could improve their overall performance. Across all the experiments and behaviors, the power in the high beta band was observed to be an important biomarker for PD as it showed differences between healthy and lesioned hemispheres and between PD and sham rats. This all shows that the 6-OHDA PD model accurately represents many of the motor and electrophysiological symptoms of PD and makes it a useful tool for the pre-clinical testing of new treatments and further investigations into this disease. Copy rights belong to original authors. Visit the link for more info
Nesse podcast sobre Engenharia da saúde (Healthcare Engineering), falamos com Nicholas Drabowski. Ele que é engenheiro de controle e automação com especialização em engenharia na saúde na Alemanha, mestrado em Deep Brain Stimulation (DBS), hoje é cientista de dados na Portal Telemedicina. Linkedin: https://www.linkedin.com/in/ndrabowski/. Portal telemedicina: https://portaltelemedicina.com.br
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.27.221853v1?rss=1 Authors: Oswal, A., gratwicke, j., Akram, H., Jahanshahi, M., Zaborszky, L., Brown, P., Hariz, M., Zrinzo, L., Foltynie, T., Litvak, V. Abstract: Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD and DLB. Here we leverage the temporal resolution of magnetoencephalography (MEG) with the spatial resolution of MRI tractography in order to explore the intersection of functional and structural connectivity of the NBM in a unique cohort of PDD and DLB patients undergoing Deep Brain Stimulation (DBS) of this structure. We observe that NBM-cortical structural and functional connectivity correlate within spatially and spectrally segregated networks including: 1) a beta band network to supplementary motor area (SMA), where activity in the SMA was found to drive activity in the NBM, 2) a delta/theta band network to medial temporal lobe structures encompassing the parahippocampal gyrus and 3) a delta/theta band network to visual areas including lingual gyrus. These findings reveal functional networks of the NBM that are likely to subserve important roles in motor control, memory and visual function respectively. Furthermore, they motivate future studies aimed at disentangling network contribution to disease phenotype. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.21.214494v1?rss=1 Authors: Khadka, N., Bikson, M. Abstract: Neurovascular-modulation is based on two principles that derive directly from brain vascular ultra-structure, namely an exceptionally dense capillary bed (BBB length density: 972 mm/mm3) and a blood-brain-barrier (BBB) resistivity ({rho} ~ 1x105 {Omega}.m) much higher than brain parenchyma/interstitial space ({rho} ~ 4 {Omega}.m) or blood ({rho} ~ 1 {Omega}.m).Principle 1: Electrical current crosses between the brain parenchyma (interstitial space) and vasculature, producing BBB electric fields (EBBB) that are > 400x of the parenchyma electric field ([E]BRAIN), which in turn modulates transport across the BBB. Specifically, for a BBB space constant ({lambda}BBB) and wall thickness (dth-BBB): analytical solution for maximum BBB electric field (EABBB) is given as:([E]BRAIN x {lambda}BBB) / dth-BBB. Direct vascular stimulation suggests novel therapeutic strategies such as boosting metabolic capacity or interstitial fluid clearance. Boosting metabolic capacity impacts all forms of neuromodulation, including those applying intensive stimulation or driving neuroplasticity. Boosting interstitial fluid clearance has broad implications as a treatment for neurodegenerative disease including Alzheimer's disease.Principle 2: Electrical current in the brain parenchyma is distorted around brain vasculature, amplifying neuronal polarization. Specifically, vascular ultra-structure produces ~50% modulation of the average [E]BRAIN over the ~40 m inter-capillary distance. The divergence of EBRAIN (activating function) is thus ~100 kV/m2 per unit average [E]BRAIN. This impacts all forms of neuromodulation, including Deep Brain Stimulation (DBS), Spinal Cord Stimulation (SCS), Transcranial Magnetic Stimulation (TMS), Electroconvulsive Therapy (ECT), and transcranial electrical stimulation (tES) techniques such a transcranial Direct Current Stimulation (tDCS). Specifically, whereas spatial profile of EBRAIN along neurons is traditionally assumed to depend on macroscopic anatomy, it instead depends on local vascular ultra-structure. Copy rights belong to original authors. Visit the link for more info
Dr. Linda Carpenter is a Professor of Psychiatry in the Alpert Medical School of Brown University and Director of the Transcranial Magnetic Stimulation (TMS) at Butler Hospital. Dr. Carpenter completed her undergraduate degree at the University of Michigan, her M.D. from the University of Pennsylvania, and internship in internal medicine, a residency program in psychiatry, and a clinical neuroscience research fellowship at Yale University. She joined the faculty at Brown in 1997 and has continued her path as a physician-scientist investigating the neurobiology of, and new treatments for, major depression and other mood and anxiety disorders. Dr. Carpenter has conducted a number of randomized clinical trials sponsored by industry and the National Institute of Health, including Deep Brain Stimulation (DBS), Transcranial Magnetic Stimulation (TMS) and transcranial Direct Current Stimulation (tDCS). She is the founding Director of the Butler Hospital TMS Clinic and Neuromodulation Research Facility where she treats patients with pharmacoresistant depression and works with a variety of Brown-based research faculty who incorporate noninvasive brain stimulation techniques into their clinical research. Dr. Carpenter’s current research projects involve using imaging and EEG biomarkers to optimize and individually customize TMS therapy for depression. Transcranial Magnetic Stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain in order to improve symptoms of neuropsychiatric disorders. It is currently FDA approved for Major Depressive Disorder and Obsessive-Compulsive Disorder. TMS is typically used when other treatments have been ineffective. TMS is a technique that applies magnetic pulses to the brain delivered by a coil which is placed on the patient’s head. The pulsed magnetic field induces an electrical current in the brain and causes activity in brain cells called neurons. Different coil types are used to induce different magnetic field patterns and how fast the pulses are delivered can determine how the brain changes in response. Stimulation pulses are typically applied at an intensity level that is customized for each individual patient.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.10.137679v1?rss=1 Authors: Parolari, L., Schneeberger, M., Heintz, N., Friedman, J. Abstract: The Subthalamic Nucleus (STN) is a component of the basal ganglia and plays a key role to control movement and limbic-associative functions. STN modulation with Deep Brain Stimulation (DBS) improves the symptoms of Parkinson Disease (PD) and Obsessive-Compulsive Disorder (OCD) patients. However, DBS does not allow for cell-type specific modulation of the STN. While extensive work has focused on understanding STN functionality, the understanding of its cellular components is limited. Here, we first performed an anatomical characterization of molecular markers for specific STN neurons. These studies revealed that most STN neurons express Pitx2, and that different overlapping subsets express Gabrr3, Ndnf or Nos1. Next, we used neuronal modulatory tools to demonstrate their roles in regulating locomotor and limbic functions in mice. Specifically, we showed that optogenetic photoactivation of STN neurons in Pitx2-Cre mice or of the Gabrr3- expressing subpopulation induces locomotor changes, and improves locomotion in a PD mouse model. Additionally, photoactivation of Pitx2 and Gabrr3 cells induced repetitive grooming, a phenotype associated with OCD. Repeated stimulation prompted a persistent increase in grooming that could be reversed by fluoxetine treatment, a first-line drug therapy for OCD. Conversely, repeated inhibition of STNGabrr3 neurons suppressed grooming in Sapap3-KO mice, a model for OCD. Finally, circuit and functional mapping of STNGabrr3 neurons showed that these effects are mediated via projections to the globus pallidus/entopeduncular nucleus and substantia nigra reticulata. Altogether, these data identify Gabrr3 neurons as a key population in mediating the beneficial effects of STN modulation thus providing a new molecular handle for PD and OCD drug discovery. Copy rights belong to original authors. Visit the link for more info
Parkinson’s Disease patient Elizabeth Larsen gives a deeply honest view of her Deep Brain Stimulation (DBS) surgery to control her tremors. We learn what it feels like to have electrodes in the brain and what happens when patients want to change their tremor management software program. Thanks to DBS, Liz triumphantly regains control over her life and returns to her boxing routine. Her surgeon, Dr. Michael Kaplitt, Director of the Movement Disorders Program at Weill Cornell Medicine, also shares exciting new treatments on the horizon.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.01.073486v1?rss=1 Authors: Tan, S. Z. K., Du, R., Perucho, J. A. U., Chopra, S. S., Vardhanabhut, V., Lim, L. W. Abstract: Neuromodulation techniques such as Deep Brain Stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcome of these treatments appears to be paradoxical, as the use of these techniques can both disrupt and enhance memory even when applied to the same brain target. In this paper, we hypothesize that disruption and enhancement of memory through neuromodulation can be explained by the dropout of engram nodes. We used a convolutional neural network to classify handwritten digits and letters, applying dropout at different stages to simulate DBS effects on engrams. We showed that dropout applied during training improves the accuracy of prediction, whereas dropout applied during testing dramatically decreases accuracy of prediction, which mimics enhancement and disruption of memory, respectively. We further showed that transfer learning of neural networks with dropout had increased accuracy and rate of learning. Dropout during training provided a more robust skeleton network where transfer learning can be applied, mimicking the effects of chronic DBS on memory. Overall, we show that dropout of nodes can be a potential mechanism by which neuromodulation techniques such as DBS can both disrupt and enhance memory and provides a unique perspective on this paradox. Copy rights belong to original authors. Visit the link for more info
Dr. Halley Briglia Alexander continues her series on epilepsy basics. This second episode focuses on Deep Brain Stimulation (DBS).
In this panel discussion, Michael Okun, MD and Kelly Foote, MD examine Deep Brain Stimulation. They share information for providers on how to decide if your Parkinson’s patient is a candidate for deep brain stimulation.
Chris Scott interviews Dr. Frank Plummer, a world-renowned physician and scientist who specializes in infectious diseases. Frank has been all over the media as Patient #1 for Deep Brain Stimulation (DBS) for alcohol addiction. This episode delves into Frank’s story, as well as this radical new possibility for treatment.
Brandon chats with Dr. Kathryn Holloway, Neurosurgeon with VCU Health, about Deep Brain Stimulation (DBS) surgery as an option to treat symptoms from Parkinson's Disease. Dr. Holloway discusses who is/isn't a great candidate for DBS, what the DBS surgery entails, safety with DBS, what to expect after DBS, and much more. Resources Mentioned VCU Parkinson's Disease Page VCU DBS Information Page Medtronic DBS Guide from Parkinson's Foundation Boston Scientific Abbott DBS Dr. Holloway's Contact Information Dr. Holloway's Biography on VCU Health Website Podcast Information Facebook Page: https://www.facebook.com/feelbettermovebetterlivebetter/ Website for Podcast: http://feelbettermovebetterlivebetter.libsyn.com/ Itunes: https://podcasts.apple.com/us/podcast/feel-better-move-better-live-better/id1468907912 Spotify: https://open.spotify.com/show/5I1HW6Fv5tYEZtk4yXpNBS Contact Information Email: brandonpoen@gmail.com
This is a special bonus episode of When Life Gives You Parkinson’s which we are calling “Extra Dosage.” Full episodes of Season 2 of the podcast will be released every other Wednesday beginning in September 2019. If you were to imagine Michael J. Fox in your mind right now. You probably are picturing the guy from Back to the Future or The Good Wife. Think about when you’ve seen him interviewed on TVnews programs or when he testified before congress. Those uncontrolled, involuntary movements Michael J. Fox is known for are not symptoms of Parkinson’s. It’s called dyskinesia. It’s a reaction to long-term levodopa use. Yes, the gold standard drug treatment for Parkinson’s, when taken over a long period of time, will effectively treat some of your PD symptoms like tremor, slowness and stiffness, but cause you to move uncontrollably. The Michael J. Fox Foundation describes it as fidgeting, writhing, wriggling, head bobbing or body swaying. It is important to note that not everyone with Parkinson’s will develop this complication. It is more common with people who are diagnosed with Young Onset Parkinson’s Disease (YOPD) or under the age of 50. There was no guarantee I would experience dyskinesia. I didn’t particularly want it. And in the end, I didn’t really have a vote. After my family returned from World Parkinson Congress in Japan in mid-June, I was jet lagged and my med times and dosages were a bit out of whack. That’s when dyskinesia took hold. It had only ever really happened once before. About six months ago. I do sometimes sway and jerk a bit here and there, but I am a relative stranger to experiencing a full-on, dyskinesia episode. It was Saturday night, my family was at the dinner table and I started to sway and rock. Slowly at first and then gradually faster and more erratic. My head started to go to the right, my shoulder popped to the left, my neck jerked back and forth. And it repeated over and over again. About 5 minutes into the dyskinesia, I asked my wife Rebecca to record a video. The dyskinesia lasted 45 minutes. I posted the video on Facebook, Twitter and Instagram accounts. For friends and family who’ve not witnessed many physical symptoms of my Parkinson’s, this came as a shock. For people familiar with PD, my episode was rather mild. Two days later, I was at a manager’s off-site meeting with 18 of my colleagues and dyskinesia set in again. It lasted an hour. And then it happened a day later during my exercise class. I was doing a bear crawl and it was as if the bear was drunk. I couldn’t tell my feel what to do anymore. It lasted 30 minutes. In this Extra Dosage episode, I turn to friends and fellow people with Parkinson’s who’ve been dealing with dyskinesia longer than I have. Becca Miller, 45, is a psychologist at a community mental health center in New Haven, Connecticut. She was diagnosed with Parkinson’s disease six years ago. She began to have dyskinesia two years ago. Jim Smerdon, 45, has been living in Vancouver, B.C., with Parkinson’s since 2007. His dyskinesia was so severe he opted for Deep Brain Stimulation (DBS) surgery in 2014 in search of relief. I wanted to get them to answer some questions I had about dyskinesia and some that my friends and family posed to me after watching the video. Also in this Extra Dosage episode, the Michael J. Fox Foundation (MJFF) has announced a series of free, daylong, live events called “Parkinson’s IQ + You.” MJFF Deputy CEO Sohini Chowdhury joined the podcast to chat about it, “the goal is to create a forum where we can share information with Parkinson’s patients, family members, friends, all with the goal of empowering people with Parkinson’s and care partners so they can optimally manage their disease and learn more about participating in research.” The “Parkinson’s IQ + You” series exciting for a number of reasons, but most relevant to me is that I have been asked to travel with the Michael J. Fox Foundation and be the host and moderator of these events across America. You can get more information at www.michaeljfox.org/PDIQ. There are other events I will be attending in the coming months that were mentioned in this episode. Saturday, August 15, 2019 – Join me at Tour de Fox Pacific Northwest in Port Coquitlam, British Columbia. Details here: https://tourdefox.michaeljfox.org/pacificnorthwest Saturday, August 24, 2019 – Join me inin Pickerington Ohio for the inaugural Tremor Trot. My nephew Anthony and his family are working with Team Fox on this family friendly 5k. You can join us or donate to the cause. Race details here: You can also donate to the When Life Gives You Parkinson’s Team here: Sunday, September 8, 2019 – I am the emcee and a walker for the Parkinson Superwalkin Vancouver. Society of British Columbia. Funds raised in BC through this event help to provide valuable support services and education offered by Parkinson Society British Columbia in BC as well as fund research efforts. You can also donate to the When Life Gives You Parkinson’s Team here. Saturday, September 14, 2019 – I will be in Atlanta, Georgia for the first “Parkinson’s IQ + You” event. Register for free here. If you have a comment or question about the podcast, you can email us: parkinsonspod@curiouscast.ca Follow me, Larry Gifford Twitter: @ParkinsonsPod Facebook: Facebook.com/ParkinsonsPod Instagram: @parkinsonspod Follow Co-host and Producer Niki Reitmayer Twitter: @Niki_Reitmayer Special thanks to… Becca Miller, Jim Smerdon, Emma Lane, Sohini Chowdury, Rebecca Gifford and Henry Gifford. Credits Dila Velazquez – Story Producer Rob Johnston – Senior Audio Producer
David Sangster is an Ambassador for World Parkinson Congress. On April 3, 2019 David is having Deep Brain Stimulation (DBS) surgery. It’s a treatment used for late-stage Parkinson’s disease that involves surgically implanting electrodes into the brain. The electrodes deliver small electric pulses which help reduce slow movement, tremor and stiffness. David was diagnosed in 2011 and lives with severe tremoring and twitching, dyskinesia, rigidity and more. He chatted with me on the podcast a couple weeks before surgery. I asked if he was nervous, “No. I just feel ready, I think. I know the risks. It’s worth it.” He’s documented his journey to DBS on his YouTube channel. His coming out party after the surgery will be attending the WPC2019 in Kyoto. There will be a lot of researchers at the congress too and for good reason according to Dr. Simon Stott, “There is never a good time to have Parkinson’s, but now is the most dynamic time for Parkinson’s research.” Stott is Deputy Director of Research at The Cure Parkinson's Trust in the UK and his website “Science of Parkinson’s” is plain English information about the research conducted on Parkinson’s. He’s been researching for the last 15 years, “When I first got into Parkinson’s research, there was one or two clinical trials that were looking at disease modification of Parkinson’s. That is slow, stop or reverse the condition. And now there is just dozens and dozens.” While he gets excited about the research, Stott is weary about expressing it too much, because he doesn’t want to raise people’s expectations. He explains that high expectations can impact research results by triggering a placebo effect and cause the group not getting the treatment to think the treatment is having beneficial effects. Additionally, Stott notes that 95% of everything that’s gone into clinical trials thus far have failed, so it’s prudent to approach whatever you’re testing with an assumption that it is going to fail. In this episode, James Heron teaches us the Japanese toast, “Kanpai!” It’s really means “dry cup” and is the equivalent to “bottom’s up!” or “cheers!” You can hear the proper pronunciation if you google the phrase online. The Japanese often remove their shoes when entering a home or restaurant. Heron says when it is expected to remove your shoes, it will be apparent. When you do take your shoes off there is usually a set of slippers they’ll give you. Heron notes that in a traditional restaurant this will get you from the entrance to the tatami mats where you will remove your slippers before sitting down in your socked feet. Most of these restaurants will also have a second set of slippers for the washrooms. Be sure to remove the washroom slippers and put your restaurant slippers back on before returning to your tatami mat. Follow me, Larry Gifford Twitter: @ParkinsonsPod Facebook: Facebook.com/ParkinsonsPod Instagram: @parkinsonspod For more info on the World Parkinson Congress head to www.WPC2019.org Facebook: Facebook.com/WorldPDCongress/ Twitter: @WorldPDCongress YouTube: WorldPDcongress Instagram: @worldpdcongress Thank you to: David Sangster, Ambassador to WPC2019 Dr. Simon Stott, Deputy Director of Research at The Cure Parkinson's Trust and Science of Parkinson’s James Heron, Executive Director of Japanese Canadian Cultural Centre
Essential Tremor Treated With High-Intensity Focused UltrasoundDr. Michael Kaplitt is the first doctor in New York to use high-intensity focused ultrasound [HIFU] to relieve a patient's Essential Tremor - ET. The procedure is part of a new clinical trial testing the use of this technology to eliminate the source of tremors in a completely non-invasive way. Dr. Kaplitt and his neurosurgical team, along with Dr. Levi Chazen from Radiology and Dr. Harini Sarva from Neurology, were able to watch as the patient's tremor diminished visibly during the procedure. [http://corebrainjournal.com/221 (Listen to his patient Steve) here at CBJ as he tells you what it felt like coming out of HIFU treatment.] Essential tremor may be mild in some individuals, but in others, it can become debilitating over time. The tremors, which are often most severe in the hands, can interfere with everyday activities such as eating, drinking, writing or tying shoelaces. Ed Note: This is an important republication from http://corebrainjournal.com/232 (CBJ/232). Patient Experience with Dr. Kaplitt's TeamWe asked for this interview after working with For a previous CBJ report from a healed golfer-patient treated by Dr. Kaplitt with HIFU listen here: http://corebrainjournal.com/221 (CBJ/221). This Ultrasound tool and the Tremor Treatment Team at Weill Cornell Brain & Spine is simply amazing. Current treatment options for ET - Essential Tremor include medication as well as Deep-Brain Stimulation (DBS), which involves implanting a battery-operated neurotransmitter under the collarbone connected to a wire that runs up the length of the neck into the scalp, where it is guided to the brain through a small hole in the skull. The tip of this wire sends the electrical impulses generated by the neurotransmitter into the precise spot in the brain that regulates the activity of the key circuits in essential tremor. In a phrase, brain surgery. http://weillcornellbrainandspine.org/faculty/michael-kaplitt-md-phd (Michael Kaplitt MD, Ph.D.,) and the Weill Cornell team are also national leaders in the use of DBS for essential tremor, Parkinson's disease, epilepsy and a variety of other disorders for more than 15 years. Listen up as Dr. Kaplitt discusses with us this remarkable new, non-invasive procedure to correct ET without brain surgery. - And he answers some of my questions about Parkinson's as well. Photo by https://unsplash.com/photos/_WKIsAKTaOU?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Nathan Dumlao) on https://unsplash.com/search/photos/spill?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Unsplash) Additional Research WorkDr. Kaplitt has pioneered human gene therapy for neurodegenerative disorders, having performed as a student the first rodent study that used the adeno-associated virus (AAV) vehicle for gene transfer to the brain. He performed the world's first human gene therapy procedure for Parkinson's disease and more recently helped to guide the first successful randomized, double-blind, sham-controlled trial of this experimental treatment, which was the first positive trial of this kind for gene therapy in any http://weillcornellbrainandspine.org/faculty/michael-kaplitt-md-phd (brain disorder). His Psychiatric Side Beyond Essential TremorHe is also pioneering the development of novel deep brain stimulation treatments for psychiatric conditions, including refractory drug addiction. Dr. Kaplitt is an internationally recognized expert in the science of gene therapy and molecular neurobiology, and his current focus is to understand molecular disease mechanisms and develop novel molecular therapies for Parkinson's disease, depression, addiction, and pain. He has published over 100 articles and has edited two books on these subjects, with publications from his lab appearing in the most prestigious international journals, including Science, Science...
Essential Tremor Treated With High-Intensity Focused UltrasoundDr. Michael Kaplitt is the first doctor in New York to use high-intensity focused ultrasound [HIFU] to relieve a patient's Essential Tremor - ET. The procedure is part of a new clinical trial testing the use of this technology to eliminate the source of tremors in a completely non-invasive way. Dr. Kaplitt and his neurosurgical team, along with Dr. Levi Chazen from Radiology and Dr. Harini Sarva from Neurology, were able to watch as the patient's tremor diminished visibly during the procedure. [http://corebrainjournal.com/221 (Listen to his patient Steve) here at CBJ as he tells you what it felt like coming out of HIFU treatment.] Essential tremor may be mild in some individuals, but in others, it can become debilitating over time. The tremors, which are often most severe in the hands, can interfere with everyday activities such as eating, drinking, writing or tying shoelaces. Patient Experience with Dr. Kaplitt's TeamWe asked for this interview after working with For a previous CBJ report from a healed golfer-patient treated by Dr. Kaplitt with HIFU listen here: http://corebrainjournal.com/221 (CBJ/221). This Ultrasound tool and the Tremor Treatment Team at Weill Cornell Brain & Spine is simply amazing. Current treatment options for ET include medication as well as Deep-Brain Stimulation (DBS), which involves implanting a battery-operated neurotransmitter under the collarbone connected to a wire that runs up the length of the neck into the scalp, where it is guided to the brain through a small hole in the skull. The tip of this wire sends the electrical impulses generated by the neurotransmitter into the precise spot in the brain that regulates the activity of the key circuits in essential tremor. In a phrase, brain surgery. http://weillcornellbrainandspine.org/faculty/michael-kaplitt-md-phd (Michael Kaplitt MD, Ph.D.,) and the Weill Cornell team are also national leaders in the use of DBS for essential tremor, Parkinson's disease, epilepsy and a variety of other disorders for more than 15 years. Listen up as Dr. Kaplitt discusses with us this remarkable new, non-invasive procedure to correct ET without brain surgery. - And he answers some of my questions about Parkinson's as well. Photo by https://unsplash.com/photos/_WKIsAKTaOU?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Nathan Dumlao) on https://unsplash.com/search/photos/spill?utm_source=unsplash&utm_medium=referral&utm_content=creditCopyText (Unsplash) Additional Research WorkDr. Kaplitt has pioneered human gene therapy for neurodegenerative disorders, having performed as a student the first rodent study that used the adeno-associated virus (AAV) vehicle for gene transfer to the brain. He performed the world's first human gene therapy procedure for Parkinson's disease and more recently helped to guide the first successful randomized, double-blind, sham-controlled trial of this experimental treatment, which was the first positive trial of this kind for gene therapy in any http://weillcornellbrainandspine.org/faculty/michael-kaplitt-md-phd (brain disorder). On The Psychiatric SideHe is also pioneering the development of novel deep brain stimulation treatments for psychiatric conditions, including refractory drug addiction. Dr. Kaplitt is an internationally recognized expert in the science of gene therapy and molecular neurobiology, and his current focus is to understand molecular disease mechanisms and develop novel molecular therapies for Parkinson's disease, depression, addiction, and pain. He has published over 100 articles and has edited two books on these subjects, with publications from his lab appearing in the most prestigious international journals, including Science, Science Translational Medicine, Nature Genetics, Nature Medicine, Proceedings of the National Academy of Science and Lancet. His basic science lab has...
In this interview, I speak with my friend, Ian Frizell, who has early onset Parkinson’s Disease. He was formally diagnosed, allegedly, in 2011 when his neurologist said “if I were a betting man, I’d bet that you have Parkinson’s,” however an official diagnosis came from his GP when Ian asked her for a sick note in 2013. “What’s wrong with you?” she asked, as she skimmed through his notes on her computer, “ah yes, you’ve got Parkinson’s”. So… diagnosed 2011/2013, Ian had been suffering from symptoms of Parkinson's Disease since about 1995. In 2015, a (different) neurologist referred him to the Deep Brain Stimulation (DBS) team at the National Hospital for Neurology and Neurosurgery (NHNN) in Queen Square, London, to assess his suitability for this operation. On the 19th of April 2016, he underwent surgery to have electrodes placed in his brain (bilateral deep brain stimulation of the sub-thalamic nucleus) and a neurostimulator in his chest. Watch and learn from Ian about his experience and fighting back against PD. Be sure to visit his website and follow his blog at: http://www.dbsacompletenobrainer.co.uk
Welcome to PsychED, the educational psychiatry podcast for medical learners, by medical learners. This episode covers the approach to treating Major Depressive Disorder, as described by the CANMAT (Canadian Network for Mood and Anxiety Treatments) Guidelines. We discuss with Dr. Sid Kennedy, the founding chair of CANMAT, the past president of International Society for Affective Disorders, as well as a staff psychiatrist and scientist at Toronto Western and St. Michael’s Hospitals in Toronto. In this episode, Dr. Kennedy discusses the origins of the CANMAT and how the guidelines are structured and constructed. We talk briefly about consideration of specifiers and symptoms in tailoring treatment. We then approach psychotherapy, pharmacotherapy, electrostimulation, and complementary and alternative therapies as treatment options, using the case from the previous episode on the diagnosis of depression. Evidence-based psychotherapies for depression include cognitive behavioral therapy (CBT), interpersonal therapy (IPT), and mindfulness-based cognitive therapy (MBCT). We explain briefly the theoretical underpinnings of each. Patient suitability and availability of quality therapy are considered. Some evidence demonstrate a superiority of combining psychotherapy with pharmacotherapy (Cuijpers 2009). The first-line pharmacotherapy includes antidepressant classes SSRI (selective serotonin reuptake inhibitor), SNRI (serotonin and norepinephrine reuptake inhibitor), NDRI (norepinephrine and dopamine reuptake inhibitor), and NaSSA (norepinephrine and specific serotonergic antidepressant). We discuss side effects with a focus on SSRIs, and understanding them from serotonin receptor profiles. We talk about the delayed onset of antidepressants, using validated tools to measure improvement, and strategies to optimize dosage, or using adjuncts with partial responses. We explore results from STAR*D (Trivedi et al, 2006) regarding response rates to medications.We touch briefly on antidepressant selection and the limited evidence of superiority of one medication/class over another (Cipriani et al 2009). Brain stimulation includes electro-convulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and Deep Brain Stimulation (DBS). Dr. Kennedy discusses the cultural origins of misconceptions around ECT and explores the current practice of ECT today, which includes general anesthesia for the comfort of patients. We explain briefly the practice of rTMS and DBS. Complementary and alternative therapies are briefly explored, including light therapy which has increasing evidence not only for seasonal patterns of depression. Dr. Kennedy discusses the limited evidence available to support any complementary therapies including nutraceuticals and exercise. The Learning Objectives for this episode are as follows. By the end of this episode, the listener will be able to: Demonstrate an approach to the treatment of depression based on severity of illness and other clinical features Apply the CANMAT Guidelines in discussing treatment options for MDD Identify psychotherapy, pharmacotherapy, brain stimulation, and complementary and alternative therapies as treatment options for MDD Psychotherapy Identify CBT, IPT, and MBCT as evidence-based psychotherapies for depression Explain factors for choosing psychotherapy versus pharmacotherapy as first-line treatment Describe the efficacy of psychotherapy in relation to pharmacotherapy Pharmacotherapy Identify SSRI, SNRI, NDRI, and NaSSA as classes of antidepressants that are first-line for depression Explain the time of onset and side effect profile of SSRIs Apply the guideline to either optimize, switch, or add adjunctive therapies with limited or partial responses to medication Identify some factors to consider in choice of antidepressants Brain Stimulation Identify ECT, rTMS, and DBS as brain stimulation treatments for depression Criticize the cultural origins of stigma around ECT Describe the current practice of ECT, rTMS, and DBS Complementary and Alternative Therapies Describe Light Therapy as the only evidence-based complementary treatment strategy Recognize the limited data in support of other therapies including nutraceuticals and exercise Guest Staff Psychiatrist: Dr. Sid Kennedy (Toronto Western Hospital and St. Michael’s Hospital, Toronto) For more PsychEd, follow us on Twitter (@psychedpodcast) and Facebook. You can provide feedback by email at psychedpodcast@gmail.com For more information visit our website: psychedpodcast.org.
In this episode of Unhinged, we talk about the area of the brain called Area 25 and how it relates to mental health.We also find out why there are some psychologists who think that Deep Brain Stimulation (DBS) is dangerous and prefer non-surgical, and even non-medicinal forms of therapy, including meditation, empathy, love, and mindfulness. […] The post Unhinged Episode #004: Area 25, DBS Detractors & Mindfulness appeared first on Unhinged.
Episode #3 gets into some details of Doug’s most radical depression treatment: brain surgery. Deep Brain Stimulation (DBS) is a neurosurgical procedure involving the implantation of a device that sends electrical impulses, through implanted electrodes, to specific parts of the brain. It’s used to treat Parkinson’s, dystonia, and chronic pain, but has also proven effective in helping […] The post Unhinged Episode #003: Deep Brain Stimulation, Cody Glode appeared first on Unhinged.
Glen Pettibone started developing Parkinson's Disease symptoms in 2008. In 2011 he was diagnosed. It was going fast and he could not tolerate most of the drugs. In January of 2013 when off meds due to food poisoning, he shook so bad he could not walk. He was taking very high doses and at the "end of the algorithm". His doctors were suggesting Deep Brain Stimulation (DBS) surgery. He did not like the high risk and marginal results he saw regarding the surgery So, he drew upon his scientific and engineering background and started reading every paper he could find. He developed a diet combining Solanaceous vegetables, featuring eggplant juice, green tomatoes, and peppers with perhaps every other suggested dietary element and suggested supplement already discussed in the Parkinson's community. Also other nutrient dense foods. Dr. Mischley's book was inspirational and helpful to him. He added more elements. He has been under her care for 6 months or so. She added intranasal glutathione which has helped. Glen is now off more than 93% of his Parkinson's disease medication. He completely cured his acid reflux, asthma, allergies and moderated his cholesterol. He regained color vision and acuity, his hearing and sense of smell are improving. His skin has tanner color and healthier texture. He has more energy, strength, and stamina. He is in the top 5 consulting employees in his company every month; sometimes number 1. Also, prior to a car accident last summer, he was off all medication for 3 months. This spring he thinks he will be again.
Can brain surgery cure addiction? Stimulating Debate on the Use of Deep Brain Stimulation (DBS) for Addiction.
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