Podcasts about diabetes risk

Dr. Hoffman continues his conversation with Jim LaValle, a Clinical Pharmacist, Author, Board Certified Clinical Nutritionist, and Heart Health Expert. 

Comprehensive Cardiovascular Health and Prevention with Jim LaValle: In this episode of the Intelligent Medicine Podcast, Jim LaValle, a clinical pharmacist and heart health expert discusses various aspects of cardiovascular health in honor of Heart Health Month. The discussion covers risk factors for heart disease, including metabolic health markers and lifestyle influences. They examine the pros and cons of statins, their impact on brain health, and the role of natural supplements like Kyolic Aged Garlic Extract in cardiovascular prevention. Specific criteria for an ideal cardiovascular risk assessment are provided, and practical advice on exercise and maintaining a balanced diet is shared. 

Send us a textControlling your glucose levels and preventing insulin spikes can seem like a daunting task, but what if mastering these skills could significantly reduce your risk of type 2 diabetes? Join me, Dr. Damaris Maria Grossman, as we unravel the complexities of glucose management. We'll go beyond the simple advice of avoiding sweets to uncover how high-carb and processed foods, artificial sweeteners, and even skipping breakfast can destabilize your glucose levels. Learn about the crucial role of quality protein, how age and gender impact insulin sensitivity, and why physical activity is non-negotiable for preventing insulin resistance. In this episode, we also dissect the hidden impacts of common medications and supplements on your insulin regulation. From steroids and birth control to antidepressants, discover how these can silently affect your insulin levels. We'll explore the promising benefits of berberine while also cautioning against certain sweeteners and flavorings. Don't overlook the connection between dental health and systemic inflammation, and understand why quality sleep is paramount for balanced insulin and sugar levels. Tune in to prioritize your well-being and take actionable steps toward becoming the best version of yourself. Support the showAre you feeling stressed, tired, or Metabolism imbalanced? Take advantage of our free mindful steps to help improve your well-being.ENJOY ONE OF our Books Mindful Ways Health Wealth & Life https://stan.store/MindfullyintegrativeAsk Us for help with Medical Weight Loss & Improve Metabolic HealthWww.mindfullyintegrative.com Let's Work on Your Optimal Wellness Journey!Sign Up For Discovery Callhttps://stan.store/MindfullyintegrativeEnjoy the Show and Get Bonus Episodes Subscribe For Just $4 a month Enjoy one of Our Mindful Book Collections HERE Check Out our YouTube Channel Join Our Mindfully Integrative Private Facebook CommunityGet 15% off Pharmaceutical Grade...

INGREDIENTS OF THE DAY:  None Mel scours the internet to find recent news stories about the American food system, which are posted at the Food Labels Revealed Podcast page on Facebook.  Four stories are selected for review and commentary on the subject of ultra-processed foods, butter made out of air, meat and type 2 diabetes, and re-invented Doritos … a little healthier. Show Notes: To Contact Show:  foodlabelsrevealed@gmail.com Facebook Page:  https://www.facebook.com/prophetofprocessedfood/?ref=bookmarks The podcast can be subscribed to at the iTunes store, or Google Play, or using most of the podcast apps available for smart phones or tablets.  Just search under Food Labels Revealed. Website:  www.foodlabelsrevealed.com FLR Book: Fast Food Ingredients Revealed: What Are You Eating? by Mel Weinstein https://tinyurl.com/59x3vk2c References: The Guardian, “20 Ways to Cut Down on UPFs While Still Eating What You Love www.theguardian.com /lifeandstyle/article/2024/sep/05/the-experts-dietitians-on-20-ways-to-cut-down-on-upfs-while-still-eating-what-you-love Smithsonian Magazine, “New Butter Made from Carbon Dioxide” www.smithsonianmag.com /smart-news/new-butter-made-from-carbon-dioxide-tastes-like-the-real-dairy-product-startup-says-180984717/ Science Daily, “Red and Processed Meat Consumption Associated with Higher Type 2 Diabetes Risk” www.sciencedaily.com /releases/2024/08/240820221808.htm Mirror, Doritos Makes Huge Change to Popular Flavors www.mirror.co.uk /money/doritos-makes-huge-change-popular-33868638 Music: Intro music is a clip from the "Peter Gunn Theme” by Henri Mancini. Outro music is “Happy Boy” by Kevin MacLeod.

It's Diabetes Awareness Month, and Dr. Natalie Azar breaks down how to manage and treat the disease. Also, Bonnie Hunt talks her new action-packed holiday movie, ‘Red One.' Plus, the 2024 Nascar Cup Series champion, Joey Logano, stops by to discuss his big win.

Can taking a selfie be good for your health? This week on StartUp Health NOW, we explore a revolutionary new approach to health screening with Kavi Misri, CEO & Founder of Hibiscus Health. Misri is a long-time Health Transformer; after his first StartUp Health portfolio company – Rose Health – was acquired, he launched Hibiscus Health and rejoined the StartUp Health Community. Discover how Hibiscus leverages smartphone selfies to analyze facial blood flow and identify potential risks for diabetes and other conditions: Easy, intuitive screenings designed for broad adoption Works with existing smartphone cameras and webcams Unlocking the potential of selfies for health screening Plus, learn about StartUp Health's Cardiometabolic Health Moonshot Community and how it helps innovative companies accelerate growth. This episode is a must-listen for anyone interested in the future of healthcare, preventive medicine, and leveraging technology for better health outcomes. Listen now and see if your selfie can unlock your potential health risks! Are you ready to tell your story? Members of our Health Moonshot Communities are leading startups with breakthrough technology-driven solutions for the world's biggest health challenges. Exposure in StartUp Health Media to our global audience of investors and partners – including our podcast, newsletters, magazine, and YouTube channel – is a benefit of StartUp Health's PRO Membership. To schedule a call and see if you qualify to join and increase brand awareness through our multi-media storytelling efforts, submit our three-minute application. If you're mission-driven, collaborative, and ready to contribute as much as you gain, you might be the perfect fit. Learn more and apply today. Want more content like this? Sign up for StartUp Health Insider™ to get funding insights, news, and special updates delivered to your inbox.

Boost Your Wellness Journey: Healthy Digestion Recipe Book for Weight Loss and Chronic Pain Relief https://rawfoodhealthempowermentsummit.com/healthy-digestion-recipe-book-download60594982 Join the Conversation: Subscribe to the Raw Food Health Empowerment Podcast and share this episode with anyone on their own path of health and transformation.  // HOST Samantha Salmon, Certified Brain Optimization Coach The information provided in this broadcast is for educational purposes only and is not intended as medical advice. These statements have not been evaluated by the food and drug administration, or the equivalent in your country. Any products/services mentioned are not intended to diagnose, treat, cure, or prevent disease.  RawFoodMealPlanner.com © 2024

National Progressive Town-hall Meeting with Representative Mark Pocan, U.S. Congress (D-WI, 2nd District) Chair Emeritus - Congressional Progressive Caucus. Also a new study, published in the journal Diabetes and Metabolic Syndrome found that people on low-carbohydrate, high-fat, and high-protein diets have increased risk of developing Type 2 diabetes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Genentech decide to remove Fuzeon from US market; Rybrevant and Lazcluze approved as first-line treatment for certain patients with EGFR-mutated advanced NSCLC; FDA warning regarding unapproved potassium phosphates; Otezla approval expanded to include treatment of pediatric patients; Results from tirzepatide diabetes risk reduction study.

Highlights today include: The Phase-Out of Fluorescent Lamps, Panasonic to End Fluorescent Lamp Production by 2027, Capitol Lighting Acquires Bellacor Brand & Digital Properties, Unlocking the Full Potential of LED Recycling, Nighttime Light Exposure Increases Type 2 Diabetes Risk, Cooper Lighting Solutions Celebrates 12 Products Selected in the 2024 IES Progress Report, Lighting Services Inc Wireless DMX Track Feeds Recognized at the 2024 IES Industry Progress Report.

As Day 2 of the DNC gets underway, the Trump campaign is blitzing key battleground states. The bodies of six Israeli hostages have been retrieved from Gaza, as negotiations for a ceasefire and hostage release deal continue. Drugmaker Eli Lilly says a popular weight loss drug cuts the risk of diabetes by 94% in certain cases. Some residents of East Palestine, Ohio want more time before a settlement deadline hits this week for last year's train derailment. Plus, a gold bar's record price and what it could mean for the US economy. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Stock market update for August 20, 2024.

ALSO: A shooting on Indy's North side leaves one person wounded... The Obama's to appear at Day 2 of the Democratic National Convention ... PLUS... The big birthday celebration happening at the Benjamin Harrison Presidential site.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

ALSO: A shooting on Indy's North side leaves one person wounded... The Obama's to appear at Day 2 of the Democratic National Convention ... PLUS... The big birthday celebration happening at the Benjamin Harrison Presidential site. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Are plant based meats putting everyone at risk for diabetes?https://youtu.be/NWv0mpnNzuU

Hay Fever: Natural Ways to Treat Seasonal Allergy SymptomsCommon origin behind major childhood allergiesYogurts Can Now Make Limited Claim That They Lower Type 2 Diabetes Risk, FDA SaysTennessee lawmaker wants rules in place for the possibility of vaccines in producehttps://www.georgebatista.comGreen Vibrance: vibrance.georgebatista.comhttps://www.instagram.com/georgebatistajr/rumble.georgebatista.comFacebook Group: https://www.facebook.com/groups/237684212669239/Email: Wellnesstalk@protonmail.com

Experts: a healthy diet can't compensate for chronic sleep deprivation. ‘Technical issue' blamed for Facebook & Instagram outage. Bafta games awards judge explains players choice shortlist. Arctic could see ‘ice-free' days in next few years. Also in this episode:Bafta games awards judge & Evening Standard journalist Vicky Jessop on the six games shortlisted for the players choice prizeWalking lowers early death risk even if rest of day spent sitting downExperts: Menopause is not a diseaseThe electric muscle era is here: Dodge launches Charger Daytona EVFollow us on X or on Threads. Hosted on Acast. See acast.com/privacy for more information.

Plant-based diet reduced diabetes risk by 24 per cent even in the presence of a genetic predisposition and other diabetic risk factors.

It's In the News, a look at the top stories and headlines from the diabetes community happening now. Top stories this week: Novo Nordisk will discontinue Levemir by the end of 2024, Tandem begins limited launch of software updates that will include Dexcom's G7, Beta Bionics iLet pump will be covered until some pharmacy plans, and lots more! Links and transcript below Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Take Control with Afrezza  Omnipod - Simplify Life Learn about Dexcom  Edgepark Medical Supplies Check out VIVI Cap to protect your insulin from extreme temperatures Learn more about AG1 from Athletic Greens  Drive research that matters through the T1D Exchange The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com   Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX In the news is brought to you by Edgepark simplify your diabetes journey with Edgepark XX This week was World Diabetes Day so there is a LOT going on.. Our top story is XX Novo Nordisk said on Wednesday it would discontinue its long-acting insulin Levemir in the United States, citing manufacturing constraints, reduced patient access and available alternatives. The Danish drugmaker said supply disruptions would start in mid-January, followed by discontinuation of the Levemir injection pen in April and of Levemir vials by the end of 2024. Novo has another long-acting insulin, Tresiba, on the market and says quote - "global manufacturing constraints, significant formulary losses impacting patient access effective in January 2024, and the availability of alternative options in the U.S. market" are key factors in the decision. The announcement comes eight months after Novo said it would cut U.S. list prices for several of its insulin products next year, including a 65% reduction in the list price of Levemir. Novo, which overtook LVMH (LVMH.PA) as Europe's most valuable listed company this year, posted record operating profit for the third quarter, with sales of its obesity drug Wegovy reaching $1.36 billion, up 28% from the previous quarter. https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-discontinue-levemir-insulin-us-market-2023-11-08/ XX Big news from Tandem Diabetes this week – first, their Control IQ algorithm gets FDA approval for children as young as two years old. the technology's original 2019 clearance limited its use to those aged 6 and older. And.. they are officially rolling out the software update that will allow users to connect to either the Dexcom G6 or G7 CGM. If you're in the limited launch you got an email this week telling you the next steps – wider release is expected gradually in the first part of 2024. Integration with Abbot's FreeStyle Libre is expected very soon as well – which would mean Tandem's tslim x2 and Mobi pumps would be compatible with three CGMs. Full disclosure: there wasn't a media release that I received on this, but my son is in the limited launch group so we got the email.   https://www.fiercebiotech.com/medtech/tandem-diabetes-care-cruises-fda-ok-toddler-use-automated-insulin-delivery-algorithm XX Beta Bionics iLet pump and its supplies are now covered as part of some pharmacy benefits - Express Scripts added it to its national formulary list. Historically, insulin pumps fall under the durable medical equipment (DME) insurance benefit. Usually pharmacy benefits are more flexible with fewer up front costs. The system uses an adaptive, closed-loop algorithm that initializes with the user's body weight and requires no additional insulin dosing parameters. The algorithm removes the need to manually adjust insulin pump therapy settings and variables. iLet simplifies mealtime use by replacing conventional carb counting with its meal announcement feature. This enables users to estimate the amount of carbs in their meal, categorized as “small,” “medium” or “large.” Over time, the algorithm learns to respond to users' individual insulin needs. https://www.drugdeliverybusiness.com/beta-bionics-pharmacy-benefit-bionic-pancreas/ XX The UK has launched a pioneering study to explore the development of type 1 diabetes in adults which aims to screen 20,000 individuals. Research will enable earlier and safer diagnosis of type 1 diabetes through blood tests. This makes the UK the first country to implement general population screening for type 1 diabetes in both children and adults. The Type 1 Diabetes Risk in Adults (T1DRA) study, launched on World Diabetes Day, seeks to enroll 20,000 adults aged 18 to 70. Supported by The Leona M. and Harry B. Helmsley Charitable Trust and building on the Diabetes UK-funded Bart's Oxford Family study (BOX), T1DRA aims to unravel the mysteries of adult-onset type 1 diabetes. https://www.diabetes.co.uk/news/2023/nov/groundbreaking-study-to-screen-20000-adults-for-type-1-diabetes.html XX The National Institute for Health and Care Excellence (NICE), England's cost-effectiveness watchdog, has finalized a draft guidance regarding hybrid closed-loop systems, concluding that the technology should be made broadly affordable and accessible to help people with Type 1 diabetes better manage the condition. In this month's final draft guidance (PDF), NICE recommended that hybrid closed-loop technology be offered to all people with Type 1 diabetes who are having trouble controlling the condition using their existing devices.   NICE said that it has already devised a five-year rollout plan with the NHS to bring the technology to people with Type 1 diabetes. Hybrid closed-loop systems will be offered first to children, young people, existing insulin pump users and women who are pregnant or planning to become pregnant, after which they'll be issued to adults who have an average HbA1c reading of at least 7.5%. https://www.fiercebiotech.com/medtech/nice-recommends-hybrid-closed-loop-systems-type-1-diabetes-prompting-praise-medtronic XX     Commercial XX Kyle Banks was diagnosed with type 1 diabetes on November 1, 2015 while performing with the traveling production of Disney's The Lion King.  Performing nightly for sold out audiences across the country was a dream come true, but after experiencing symptoms of the onset of type 1 diabetes, the dream temporarily turned into a nightmare. The symptoms he experienced were  typical for the onset of this chronic illness. but with limited knowledge of type 1 diabetes, he had no idea what was occurring or the drastic life change that would soon follow.  In 2020, he founded Kyler Cares in partnership with Children's Hospital New Orleans and has since connected with families from across the country that are living with this disease.  Kyler Cares seeks to improve health outcomes for people of color living with diabetes and ensuring families can access the resources and technology available for better management is the route the organization is taking to achieve that goal. At Kyler Cares we're working to improve health outcomes for people of color living with diabetes by improving access to diabetes technology, creating connections to education and resources, and fostering community as an added system of support on our journeys. Kyler Bear & Friends' T1 Diaries is an eight-part animated series for kids, dedicated to storytelling about life with Type 1 Diabetes. Our series is more than just an educational tool; it's a reflection of real-life stories and an avenue to strengthen community ties. It's a vehicle for us to inspire young people to begin laying a foundation of knowledge and self-confidence with management of T1D that will resonate throughout their lives until a cure for the disease is discovered.   By supporting this series with a donation, you will be contributing to a project that not only educates and informs but also offers comfort and a sense of belonging to kids navigating life with T1D. ‘Kyler Bear's T1 Diaries' isn't just a series; it's a beacon of hope, a source of information, and a testament to the strength found in our amazing T1D community. Join us in bringing these stories to life XX Married At First Sight UK ends this week, but one bride says viewers haven't seen her whole story.   Fans will find out if Tasha Jay, 25, decides to stay with partner Paul Liba on the Channel 4 show.   But Tasha, who has type 1 diabetes, has spoken out about how footage about her condition didn't make the final cut.   While she's "really sad" that it was left out, Tasha's pleased that people are now realising why she behaved in a certain way on the show at times.     Married at First Sight - or MAFS - is a social experiment where experts match complete strangers who try to live as a couple.   Tasha says her wedding day with Paul on the show was a "really beautiful moment" that included her telling Paul about her diabetes and his reaction.   "I got filmed taking my insulin and checking my blood sugar," she tells BBC Newsbeat.. Tasha was diagnosed at aged two and half and says people have asked why that part of her was hidden in the show.   "And I'm like I didn't hide it," she says.   "For whatever reason they haven't shown it, which really upsets me because diabetes is a part of my story."   Tasha believes that, if people had known about her diabetes, it would have changed their perception of certain moments in the show. https://www.bbc.com/news/newsbeat-67368445

#BRNAM #1536 |  Red meat consumption is associated with increased type 2 diabetes risk | Dr. Xiao Gu, Harvard University    | #Tunein: broadcastretirementnetwork.com #JustTheFacts

Tuesday, October 24th — In this episode we talk about: Doug's weekend festival, Matt sees Messi play Weather report: Kiwis help with sleep, study finds red meat associated with 62% increase in type-2 diabetes risk Aussie Boy 'Bullied' for Vegan Birthday Party (https://au.news.yahoo.com/aussie-boy-bullied-for-vegan-birthday-party-030048929.html) Kelly Clarkson says the 'Plant Paradox' Diet Helped Her Get Healthy, But is it Safe? (https://www.healthline.com/health-news/kelly-clarkson-diet) Tune in live every weekday at 11am to watch on YouTube or on Instagram (@plantbasedmorningshow and @nomeatathlete_official), or watch on Twitter or Twitch! Follow @plantbasedmorningshow, @realmattfrazier, and @itsdoughay for more.

The study, by researchers from the University of Adelaide in Australia and Southeast University in China, found that compared with never tea drinkers, daily consumers (never, occasionally, often and every day) ) of dark tea had 53% lower risk for prediabetes and 47% reduced risk for type 2 diabetes, even after taking into account established risk factors known to drive the risk for diabetes, including age, gender, ethnicity, body mass index (BMI), average arterial blood pressure, fasting plasma glucose, cholesterol, alcohol intake, smoking status, family history of diabetes and regular exercise. #darktea #bloodsugar #diabetes Poster presentation 329 at the annual meeting of the European Association for the Study of Diabetes (EASD), Tea consumption is associated with increased urinary glucose excretion, improved insulin resistance and reduced risk of dysglycaemia, in Chinese community-dwelling adults T. Li, M. Sang, J. Wang, Z. Sun, C. Xie, C. Rayner, M. Horowitz, S. Qiu, T. Wu, Australia, China --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

Dark tea may Dramatically HELP control blood sugar to reduce diabetes risk Episode 1158 OCT 2023 The study, by researchers from the University of Adelaide in Australia and Southeast University in China, found that compared with never tea drinkers, daily consumers (never, occasionally, often and every day) ) of dark tea had 53% lower risk for prediabetes and 47% reduced risk for type 2 diabetes, even after taking into account established risk factors known to drive the risk for diabetes, including age, gender, ethnicity, body mass index (BMI), average arterial blood pressure, fasting plasma glucose, cholesterol, alcohol intake, smoking status, family history of diabetes and regular exercise. #darktea #bloodsugar #diabetes Poster presentation 329 at the annual meeting of the European Association for the Study of Diabetes (EASD), Tea consumption is associated with increased urinary glucose excretion, improved insulin resistance and reduced risk of dysglycaemia, in Chinese community-dwelling adults T. Li, M. Sang, J. Wang, Z. Sun, C. Xie, C. Rayner, M. Horowitz, S. Qiu, T. Wu, Australia, China --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

During the COVID-19 pandemic, the incidence of diabetes in childhood increased. JAMA Associate Editor Anne R. Cappola, MD, ScM, and Ezio Bonifacio, PhD, from the Center for Regenerative Therapies at the Dresden University of Technology, discuss SARS-CoV-2 infection and its association with islet autoimmunity in early childhood. Related Content: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood

During the COVID-19 pandemic, the incidence of diabetes in childhood increased. JAMA Associate Editor Anne R. Cappola, MD, ScM, and Ezio Bonifacio, PhD, from the Center for Regenerative Therapies at the Dresden University of Technology, discuss SARS-CoV-2 infection and its association with islet autoimmunity in early childhood. Related Content: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood

For those at risk of developing Type 2 diabetes, a small change in breakfast…

For those at risk of developing Type 2 diabetes, a small change in breakfast time can make a big difference. Eating breakfast after 8 a.m. heightens the risk of developing...

In this episode, Nurse Doza discusses the importance of the hemoglobin A1C lab test in diagnosing diabetes and managing blood sugar levels. He explains that a range of 6 to 6.4 is typically considered indicative of diabetes, while a range of 5.6 to 5.7 is classified as pre-diabetes. Nurse Doza also emphasizes the benefits of maintaining a lower A1C level, which can help protect against conditions like heart disease and vascular dementia. He advises getting the A1C test done annually and highlights the importance of not only monitoring blood sugar but also ensuring that insulin levels are properly regulated.

This Week In Wellness researchers from the University of California, Berkeley, have uncovered a potential mechanism for the increased diabetes risk seen in those who do not get enough sleep.  https://www.news-medical.net/news/20230707/Research-uncovers-mechanism-linking-deep-sleep-to-blood-sugar-control.aspx https://linkinghub.elsevier.com/retrieve/pii/S2666379123002197

From Susie and Leanne on The Nutrition Couch this episode: We talk diabetes risk factors and when you should be getting your insulin levels checked. We review a new, cost effective protein option: Sunny Farm Protein Bites. Our recipe of the week is Susie's extra virgin olive oil cookies. So sit back, relax and enjoy this week's episode!  Tune in on Sunday for our next episode. Don't Miss an Episode   Don't forget to subscribe to the podcast so you never miss an episode and follow us on social media @the_nutrition_couch_podcast to ask us questions & see our food product reviews.  It would mean the world to us if you could leave us a 5 star review in the purple Apple podcast app (scroll to the bottom of the app to find the ratings and reviews) as this really helps push up higher in the charts to expose our podcast to more ears.  Please follow Susie on her Instagram & Facebook and Leanne on her Instagram, TikTok and the Leanne Ward Nutrition Podcast. See omnystudio.com/listener for privacy information.

Have you tested with high A1C levels? Are you in pre-diabetes? Has the doctor told you that you need to make some changes? Are you supposed to cut carbs to get to  A1C normal range, but don't know how many carbs per day you should be getting?If you don't know where to start, what you need to be changing, or even what a normal A1C level is, today's episode is for you. My friend, nurse, and cyclist Tracy Tolson is here to sing to the choir. Tracy is a very fit 62 year old with no family history of high A1C levels, yet a year ago got the news from her PCP - Primary Care Physician that she needed to meet with an endocrinologist and nutritionist to get her A1C levels down before she was in full-blown diabetes. It was a wake up call and she made the necessary changes to get level down herself WITHOUT the use of medication. And she is here on the pod to tell us all how she did it and to encourage you to do the same if you are in the same boat. If you need help making the changes that we talk about today - make sure to come find me - All of the links are below - I hope to work with you soon.Come talk to me here:Find me on my Website:https://www.lesleylmcshane.comFREE: Midlife in Motion ROADMAP I want more details on the MIDLIFE IN MOTION program:I don't need details, I want IN in the MIDLIFE IN MOTION program:Schedule a Kickstarter Call to get your nutrition and fitness on track!Connect with me on Instagram:Get Redesigning Midlife Weekly Updates:Find your community at the private Redesigning Midlife Facebook Group:You Deserve It Notebook: Goal Tracker, Planner, ...

Eat healthy food. Exercise regularly. Lose weight. These have all been good prescriptions for…

A shock from Ford. The company says it's paused production and shipment of its new electric F-150 Lighting pickup because of a potential battery issue. This comes as Ford is looking to become a big player in the electric vehicle market. We go In Depth into whether Ford is ready to rival big EV companies like Tesla. Santa Monica might declare a state of emergency over the homeless crisis. But could that lead to even more problems? Former President Trump has an official Republican challenger now. She even served in his administration. A new study from doctors here in LA shows why COVID can do more than just make you feel bad for a few days. It's linked to an increased risk of a serious disease. Before you go out and buy that last-minute box of chocolates for Valentine's Day you'll want to listen to our last segment. Those boxes are full of..well..not much. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

A shock from Ford. The company says it's paused production and shipment of its new electric F-150 Lighting pickup because of a potential battery issue. This comes as Ford is looking to become a big player in the electric vehicle market. We go In Depth into whether Ford is ready to rival big EV companies like Tesla.  Santa Monica might declare a state of emergency over the homeless crisis. But could that lead to even more problems?  Former President Trump has an official Republican challenger now. She even served in his administration.  A new study from doctors here in LA shows why COVID can do more than just make you feel bad for a few days. It's linked to an increased risk of a serious disease.  Before you go out and buy that last-minute box of chocolates for Valentine's Day you'll want to listen to our last segment. Those boxes are full of..well..not much. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

In this episode we chat with special guest, Leslie Flannery, who is a Registered Dietitian specializing in gestational diabetes. We talk about common misconceptions with GD, risk factors, how to prepare for the test, and 3 tips to manage your blood sugar early on in pregnancy (and beyond!). Whether you have GD or not, you'll have some tangible tips to take with you for balanced nutrition in pregnancy. Connect with Leslee on Instagram @gestational.diabetes.nutrition Work with me 1:1 Pre/postnatal Performance Coaching Connect with me on Instagram! @strongmamawellness Learn more about my work on the website

In this episode we chat with special guest, Leslie Flannery, who is a Registered Dietitian specializing in gestational diabetes. We talk about common misconceptions with GD, risk factors, how to prepare for the test, and 3 tips to manage your blood sugar early on in pregnancy (and beyond!). Whether you have GD or not, you'll have some tangible tips to take with you for balanced nutrition in pregnancy. Connect with Leslee on Instagram @gestational.diabetes.nutrition Work with me 1:1 Pre/postnatal Performance Coaching Connect with me on Instagram! @strongmamawellness Learn more about my work on the website

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1 in 3 people in the US population have prediabetes- could you be one of them? Physician, Chief Medical Officer of WebMD and author, Dr. John Whyte MPH joins to empower listeners to take control of their prediabetes and diabetes in this important and inspiring episode. Dr. Whyte shares that blood sugars in prediabetes and type 2 diabetes can be reversed to normal under certain circumstances. The Doctors cut through the misinformation and share scientifically supported strategies and practically healthy prescriptions to promote diabetes management- they discuss exercise, food as medicine (including spices), sugar consumption, supplements, stress and more! A must listen for anyone with prediabetes or diabetes looking to prevent and possibly reverse the impact of blood sugar.  To learn more about Dr. John Whyte and his new book, “Take Control of Your Diabetes Risk”, follow him @drjohnwhyte.

As a midlife woman your diabetes risk increases as hormones change. This episode intends to help you realize that you are in control. We include what may be reminders for many of you, or new points of awareness for others. This may be for you or for loved ones struggling with insulin resistance, pre-diabetes, or diabetes. In this episode I interview Dr. John Whyte, the Chief Medical Officer for WebMD, about his new book. Take Control of Your Diabetes Risk is available wherever books are sold and yet don't go get it yet, tune into this episode. You're going to love the simple tips reminding you of easy ways not to only avoid disease, but to feel better.  Strength training to increase muscle which acts like a sponge for blood sugar. During Open Enrollment for the Flipping 50 Cafe you can gain access to made-for-menopause strength training programs and coaching from the leading hormone balancing fitness expert.  Listen for the mic drop moment, followed by a comment we can each relate to all too well.  We discuss some resources I'll add to the show notes as well.  My Guest:  Dr. John White is the Chief Medical Officer, WebMD. In this role, he leads efforts to develop and expand strategic partnerships that  create meaningful change around important and timely public health issues. Prior to WebMD, he served as the director of professional affairs and stakeholder engagement at the Center for Drug Evaluation and Research at the U.S. Food and Drug Administration.  00:00 Questions we answer in this episode: 02:30 why do we have a diabetes epidemic in the US?  05:26 knowing genetics play a small percent, are genetics largely to blame or is it something else?  08:28 is it possible to either reverse diabetes entirely, or only to prevent it from occurring if you're at risk?  are there issues specific to midlife women and diabetes? 20:42 how do hormones play a role?  what's the role of stress in diabetes risk?   what kinds of exercise choices do you find make the biggest difference? 31:12 are there types of exercise that don't help much at all specifically with diabetes and blood sugar? Connect with Dr John Whyte:  https://www.webmd.com/takecontrol/diabetes On Social Media: Twitter: https://www.twitter.com/drjohnwhyte Linked In: https://www.linkedin.com/in/john-whyte-00092833/ The book you'll want for your library:  https://www.amazon.com/Take-Control-Your-Diabetes-Risk/dp/0785240640/ref=sr_1_1?crid=497HJ4ETSJVQ&keywords=take+control+of+your+diabetes+risk&qid=1654539216&sprefix=take+control+%2Caps%2C80&sr=8-1 Resource mentioned in this episode:  Continuous Glucose Monitor (for $25 off your first month, Rx not required): https://www.flippingfifty.com/glucose  Other Episodes You May Like Related to Diabetes Risk: How a Continuous Glucose Monitor Could Help Weight Loss: https://www.flippingfifty.com/glucose-monitor/ My 30-Day Glucose Monitor Experiment: What Happened: https://www.flippingfifty.com/glucose-monitor/ 4 Ways Blood Sugar Could Halt Your Fat Burning and Weight Loss: https://www.flippingfifty.com/glucose-monitor/ Join the Free Diabetes Summit Now (July 2022) 

BACK on Air is THE podcast for operators who have compliance on their mind and road transport at the heart of their business.  This podcast is a recording of our live  fortnightly webinar held every other Friday.  So, if you like what you hear and fancy joining the live event where you can ask questions, and vote on our interactive polls, Just register through this link: https://www.backhousejones.co.uk/events/In this episode we have a guest speaker in this area: Kate Walker, CEO of The Diabetes Safety Organisation (https://diabetessafety.org/).We talk about protecting people and businesses against diabetes risk and liability and the "One Less" challenge (https://diabetessafety.org/one-less-challenge/).  We also discuss:Notification requirements to the DVLA of medical conditions.Notification requirements of employees with health issues.Handling situations with employees with different conditions.Creating a well-being culture.The repercussions of getting it wrong.This fortnight's “quiet but important rule change” is changes to Transport Manager requirements…The content of this podcast is correct at the time of broadcasting and isn't meant to be specific legal advice.  If you need advice, we recommend that you take proper legal advice for your individual situation.Please leave us a review and of course details of any areas you would like us to cover in Your employees' health and your businessfuture episodes.  We do read them and it helps others find our podcast. Enjoy!Contact: marketing@backhouses.co.ukWebsite: www.backhousejones.co.uk

A recent study shows that increased exercise improves metabolic markers and takes a broad look at the molecules impacted by physical activity. Author: Colleen Gulick, PhD Reviewer: Matthew Laye, PhD Link to article: https://www.levelshealth.com/blog/new-research-sheds-light-on-metabolites-exercise-and-type-2-diabetes-risk Become a Levels Member – levelshealth.com Learn about Metabolic Health – levelshealth.com/blog Follow Levels on Social – @Levels on Instagram and Twitter

Today, I am blessed to have John Whyte, MD, MPH, with me. Whyte is the Chief Medical Officer, WebMD. In this role, Whyte leads efforts to develop and expand strategic partnerships that create meaningful change around important and timely public health issues. Dr. Whyte is also the author of the Take Control series including Take Control of Your Diabetes Risk and Take Control of Your Cancer Risk books. Here's What We Cover in this Episode:About Dr. Whyte and His Passion For Policy Issues In The Medical CommunityThe Challenges That Arise With Innovation in Medicine How Dr. Whyte's Practice Has Changed Over The YearThe Different Pillars of Health That Are Impacting Our WellnessHow Dr. Whyte Optimizes His Sleep Habits and Sleep Hygiene TipsMost Cancers Are Caused By A Combination of Lifestyle IssuesThe Importance of Recognizing Mental Health and How To Navigate Depression and Anxiety150 Minutes Each Week: Exercise Recommendations From Dr. WhyteAND MUCH MORE!Resources from this Episode: Check out WebMD: https://www.webmd.com/Get Dr. Whyte's book, Take Control: https://www.webmd.com/takecontrolFollow Dr. WhyteInstagram: https://www.instagram.com/drjohnwhyteTwitter: https://twitter.com/drjohnwhyteCoachingIf you're ready to lose the weight for good, you've come to the right place!Join my online course, Zivli, to learn the science behind weight loss and habit change so you can lose weight, get healthy, and prevent disease. Also included with the program are weekly office hours with me and a membership site for encouragement, accountability, and support from other members. To learn more, go to https://www.zivli.com/join.Free Weight Loss ResourcesWeight Loss Masterclass to Lower Insulin Resistance & InflammationThe 5% Mindset | How to Win at Weight LossThe Ultimate Food Guide | What to Eat to Burn FatConnect on Social>> Subscribe to My YouTube Channel>> Like My Facebook Page>> Follow Me on Instagram>> Connect on LinkedIn>> View My WebsiteSubscribe & Review in Apple PodcastsAre you subscribed to my podcast? If you're not, I want to encourage you to do that today. I don't want you to miss an episode. Click here to subscribe in Apple Podcasts.Now if you're feeling extra loving, I would be really grateful if you left me a review over on Apple Podcasts, too. Those reviews help other people find my podcast and they're also fun for me to go in and read. Just click here to review, select “Ratings and Reviews” and “Write a Review” and let me know what your favorite part of the podcast is. Thank you!

Eat healthy food. Exercise regularly. Lose weight. These have all been good prescriptions for…

We discuss Dr. John Whyte's latest book, Take Control of Your Diabetes Risk, and reveal what it offers patients struggling with diabetes. Dr. Whyte is the Chief Medical Officer, WebMD. He leads efforts to develop and expand strategic partnerships that create meaningful change around important and timely public health issues. Prior to WebMD, Whyte served as the director of professional affairs and stakeholder engagement at the Center for Drug Evaluation and Research at the U.S. Food and Drug Administration.

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This issue will review: Remission of Type 2 Diabetes Following a Short-term Intensive Intervention With Insulin Glargine, Sitagliptin, and Metformin Gestational Diabetes Mellitus and the Risks of Overall and Type-Specific Cardiovascular Diseases Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease Changes in the Prevalence of Symptoms of Depression, Loneliness, and Insomnia in U.S. Older Adults With Type 2 Diabetes During the COVID-19 Pandemic Relationships of Changes in Physical Activity and Sedentary Behavior With Changes in Physical Fitness and Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia     For more information about each of ADA's science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

November is National Diabetes Month. And while diabetes should be a daily conversation, early detection is key. This week, Millennium Physician Group's Michelle McCormick talks with an Endocrinologist about knowing your diabetes risk and how to make smart food choice to avoid prediabetes.

Episode 385. Investigating myself. Topic: Diabetes risk. How do genetics influence risk for type I and II diabetes? How can risk be quantified? What are my risk scores for these diseases? How can I use this information to prevent diabetes?Twitter: @3minutelessonEmail: 3minutelesson@gmail.comInstagram: 3minutelessonFacebook: 3minutelessonNew episode every Monday, Wednesday, and Friday! Find us everywhere podcasts are found.Methodology notes: Variants associated with type II diabetes were assessed with a gvcf upload to Promethease.

Here are 10 reasons why you should watch this video and take your sleep seriously:1. Poor Sleep Can Make You Fat.In one extensive review study, children and adults with short sleep duration were 89% and 55% more likely to become obese, respectively.2. Good Sleepers Tend to Eat Fewer Calories.Sleep deprivation disrupts the daily fluctuations in appetite hormones and is believed to cause poor appetite regulation.3. Good Sleep Can Improve Concentration and Productivity.Interns on a traditional schedule with extended work hours of more than 24 hours made 36% more serious medical errors than interns on a schedule that allowed more sleep.4. Good Sleep Can Maximize Athletic Performance.In a study on basketball players, longer sleep was shown to significantly improve speed, accuracy, reaction times and mental wellbeing.5. Poor Sleepers Have a Greater Risk of Heart Disease and Stroke.A review of 15 studies found that people who don't get enough sleep are at far greater risk of heart disease or stroke than those who sleep 7–8 hours per night.6. Sleep Affects Glucose Metabolism and Type 2 Diabetes Risk.In a study in healthy young men, restricting sleep to four hours per night for six nights in a row caused symptoms of prediabetes.7. Poor Sleep Is Linked to Depression.It has been estimated that 90% of people with depression complain about sleep quality.8. Sleep Improves Your Immune Function.They found that those who slept less than seven hours were almost three times more likely to develop a cold than those who slept eight hours or more.9. Poor Sleep Is Linked to Increased Inflammation.Poor sleep has been strongly linked to long-term inflammation of the digestive tract, in disorders known as inflammatory bowel diseases.10. Sleep Affects Emotions and Social Interactions.One study found that people who had not slept had a reduced ability to recognize expressions of anger and happiness.----------------------------------------------------------------------------------------------Bo-Fit Sleep Support Supplement: https://bofitstudio.com/shopMore from your host Bo Skitsko:Bo-Fit Supplements:https://bofitstudio.com/shopGet my Book

呼吸科星期二 2020年11月3日 第2集FDA 免疫检查点抑制剂进入肺癌的一线治疗NEJM 治疗耐药结核时，短疗程方案不劣于长疗程方案Cell CT的人工智能系统可用于诊断COVID-19德瓦鲁单抗（durvalumab）德瓦鲁单抗是一种PD-L1单抗，此前已被批准用于治疗晚期膀胱癌和无法切除的3期非小细胞肺癌。2020年3月，德瓦鲁单抗被批准用于广泛期小细胞肺癌联合标准化疗的一线用药。《CASPIAN研究：德瓦鲁单抗联合铂-依托泊苷治疗广泛期小细胞肺癌的疗效》Lancet，2019年11月 (1)这项研究的目的是评估德瓦鲁单抗与依托泊苷联合顺铂或卡铂治疗广泛期小细胞肺癌的疗效，对照组方案是依托泊苷联合顺铂或卡铂。这项随机、开放标签、三期试验，纳入未经治疗的、广泛期小细胞肺癌患者537人，随机分为德瓦鲁单抗+铂/依托泊苷组、铂/依托泊苷组。联合德瓦鲁单抗组总生存率显著改善，优势比为0·73（p = 0·0047）。联合德瓦鲁单抗组和不使用德瓦鲁单抗组中，中位总生存期分别为13·0个月和10·3个月；随访至18个月时，两组分别有34%和25%的患者存活。结论：一线德瓦鲁单抗联合铂/依托泊苷显著改善广泛期小细胞肺癌患者的总生存率。纳武利尤单抗+ 伊匹木单抗（nivolumab+ipilimumab）2020年5月，FDA批准纳武利尤单抗（抗PD-1单抗）和伊匹木单抗（CTLA-4单抗），两个药物联合低剂量化疗作为转移或复发的非小细胞肺癌的一线治疗方案。《CheckMate 227研究：纳武利尤单抗联合伊匹木单抗治疗晚期非小细胞肺癌的3期临床研究》New England of Medicine，2019年11月 (2)此项开放标签的3期临床研究的目的是，评价晚期非小细胞肺癌患者中使用PD-1单抗（纳武利尤单抗）+CTLA-4单抗（伊匹木单抗）联合治疗的长期获益。研究纳入PD-L1表达水平≥1%的、Ⅳ期或复发的、非小细胞肺癌患者，随机分入纳武利尤单抗+伊匹木单抗双联治疗组、或纳武利尤单抗单药治疗、或化疗组；同时也纳入了PD-L1表达水平＜1%的患者，随机分三组中。所有患者之前均未接受过化疗。在PD-L1表达水平≥1%的患者中，纳武利尤单抗+伊匹木单抗组和化疗组的中位总生存期分别为17.1个月和14.9个月（P=0.007），2年总生存率分别为40.0%和32.8%，中位缓解时间分别为23.2个月和6.2个月。在PD-L1表达水平＜1%的患者中也观察到了总生存期获益，纳武利尤单抗+伊匹单抗组和化疗组的中位总生存期分别为17.2个月和12.2个月。全部患者中，纳武利尤单抗+伊匹单抗组和化疗组的中位总生存期分别为17.1个月和13.9个月，严重不良事件发病率分别为32.8%和36.0%。结论：在非小细胞肺癌患者中，纳武利尤单抗+伊匹木单抗一线治疗组的总生存期超过化疗组，且与PD-L1表达水平无关。长期随访中未发现新的安全性问题。阻塞性睡眠呼吸暂停阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是一种因睡眠过程中上气道反复塌陷引起的、以阻塞性呼吸暂停和低通气为特征的疾病。对于存在白天睡眠过多、打鼾和睡眠中窒息或倒吸气等症状的、高龄、肥胖、男性患者，应该考虑这个诊断。多导睡眠监测图是诊断的金标准，诊断标准为：无相关疾病或症状者，睡眠期间阻塞性为主的呼吸事件≥15次/小时；伴有相关疾病或症状者，睡眠期间阻塞性为主的呼吸事件≥5次/小时。相关症状包括：嗜睡、疲劳、失眠，觉醒时存在憋气、倒吸气或窒息，或者观察者发现患者习惯性打鼾、呼吸中断。相关疾病包括：高血压、心境障碍、认知功能障碍、冠心病、脑卒中、心力衰竭、心房颤动或2型糖尿病。《前瞻性研究：睡眠呼吸障碍和失眠与高血压和糖尿病的关系》American Journal of Respiratory and Critical Care Medicine，2020年7月 (3)这项前瞻性研究，通过长达6年的随访，旨在调查美国西班牙裔/拉丁裔人群中，睡眠呼吸障碍和失眠与高血压和糖尿病发生之间的关联，共纳入11623名参与者，女性占52.6％，平均年龄41.1±14.9岁。存在睡眠呼吸障碍的人群，与没有睡眠呼吸障碍的人群比较，高血压发生的风险比1.54，糖尿病发生风险比1.37。失眠与高血压有关（风险比1.37），其中男性关联性更强。结论：睡眠呼吸障碍与高血压和糖尿病有关。失眠与高血压有关。这些结果支持将睡眠障碍作为预防和减少高血压、糖尿病的靶标。《SAVE研究：持续气道正压治疗对同时患有OSA和稳定性冠心病的患者的糖尿病的影响》Diabetes Care，2020年7月 (4)研究试图确定在同时患有稳定性冠心病和OSA患者中，长期持续气道正压（CPAP）通气治疗对血糖控制和糖尿病风险的影响。研究收集了888名同时患有稳定性冠心病和OSA患者，一组接受CPAP加常规治疗，另一组接受常规治疗，中位随访时间为4.3年。糖尿病的患者中，不同治疗组的血糖、糖化血红蛋白或降糖药物使用方面无显著差异。糖尿病前期、或新诊断的糖尿病患者中，组间也没有显著差异。有趣的是，女性糖尿病患者在常规治疗组表现较差，而接受CPAP治疗后病情更稳定。结论：在同时患有稳定性冠心病和OSA患者中，尚无证据证明长期CPAP治疗对血糖控制有益。但研究中发现的性别差异仍需进一步验证。阻塞性睡眠呼吸暂停的治疗一般治疗包括：减重、运动、侧卧位睡眠、避免酒精、避免使用精神类药物。主要治疗方法是气道正压治疗，常见模式包括持续气道正压（CPAP）、双水平气道正压（BPAP）和自动调定式的气道正压（APAP），最常用的是CPAP。替代治疗方法包括：轻中度患者可尝试口腔矫正器、存在上气道阻塞的患者可尝试上气道外科手术、也可尝试直接或间接刺激呼吸驱动的药物（如茶碱或乙酰唑胺）、或减少上气道塌陷的药物（如地昔帕明）。《对照研究：腭舌手术治疗中重度阻塞性睡眠呼吸暂停的患者》JAMA，2020年9月 (5)研究的目的是考察了腭舌手术对阻塞性睡眠呼吸暂停综合征（OSA）常规治疗失败患者的疗效。研究纳入常规治疗失败的、症状性的、中重度、阻塞性睡眠呼吸暂停患者101人，随机接受多次腭舌手术（改良悬雍垂腭咽成形术和微创舌体积缩小术）、或常规医疗（例如，改善睡眠姿势或减肥）。89%的患者完成了试验，手术组基线时的平均睡眠呼吸暂停低通气指数为47.9，6个月时为20.8；常规医疗组基线时为45.3，6个月时为34.5（6个月时，组间平均校正后差异为-17.6个事件/小时）。手术组基线时的Epworth嗜睡评分为12.4，6个月时为5.3；常规医疗组基线时为11.1，6个月时为10.5（6个月时，平均基线调整组间差异-6.7）。不良事件：手术组1例术后第5天发生心肌梗死，1例因吐血而住院观察。结论：常规治疗失败的、中重度阻塞性睡眠呼吸暂停症患者，接受悬雍垂腭咽成形术和微创舌体积缩小术，可减少呼吸暂停和低通气事件的发生，改善患者嗜睡症状。肺结核肺结核是结核分枝杆菌感染最常见的部位。（1）原发性肺结核主要发生于儿童期，也可以在青少年或成人中发生，其临床表现在人群中差异很大：低热70%、胸膜炎性胸痛25%、乏力咳嗽咽痛比较少见。X线表现：肺门淋巴结肿大65%，胸腔积液33%，肺部浸润27%。原发性感染后，90%的免疫系统正常者可以控制结核杆菌的进一步复制；随后结核杆菌可能进入潜伏期，10%的感染者进行性的出现肺结核肺炎。（2）复燃性肺结核的患者发热和盗汗更常见，约一半的患者有咳嗽、体重减轻、乏力。X线表现：上叶尖后段受累80-90%，空洞形成20%。《系统回顾和荟萃分析：近距离接触结核病人后，儿童罹患肺结核的风险》Lancet，2020年3月 (6)全球每年有数千万儿童接触结核分枝杆菌，但是，仍没有对受感染儿童罹患结核病的风险的估计，对接触调查和预防治疗的有效性也缺乏了解。在这篇系统回顾和荟萃分析中，纳入了来自34个国家的46个队列研究的数据。评估了137647例结核暴露儿童，对135512例儿童进行了429538人年随访，期间诊断出1299例流行性结核和999例散发性结核。结核感染阳性、但未接受预防治疗的儿童2年累计肺结核发病率明显高于结核感染阴性儿童。其中5岁以下儿童肺结核发病率最高，为19·0%。所有暴露儿童预防治疗的有效性为63%，对于结核感染阳性儿童预防治疗的有效性为91%。结论：结核暴露的婴儿和幼儿罹患结核病的风险非常高，大多数病例发生在接触者调查开始后的几周内。《前瞻性研究：接触耐多药结核病后异烟肼的防治效果》American Journal of Respiratory and Critical Care Medicine，2020年6月 (7)WHO建议单独使用异烟肼或异烟肼与利福平联合使用来治疗潜在的结核病感染。该研究的目的是研究单独使用异烟肼用于预防多药耐药结核感染的有效性。这个前瞻性群组研究纳入4500个肺结核病人和14044个结核暴露家庭，19岁以下的接触者共4216人，只有一半人接受了异烟肼预防治疗。异烟肼的预防作用十分显著，在接触非耐药结核病人时感染风险下降70%，在接触多药耐药结核病人后的感染风险下降81%。在接触异烟肼单药耐药结核病人时，异烟肼的预防作用稍弱（风险比0.80）。在第二项独立研究中，76名接受异烟肼预防的家庭接触者均未感染；而273名未接受异烟肼预防治疗的家庭接触者有8人感染，占3%。结论：即使接触多药耐药结核病患者，异烟肼也能有效降低接触者的结核发病率。《随机对照研究：补充维生素D预防结核杆菌感染》New England Journal of Medicine，2020年7月 (8)研究的目的是评估补充维生素D是否可以预防结核病感染。参与研究的8851名、结核分枝杆菌感染阴性的、维生素D缺乏的儿童，随机分入维生素D组或安慰剂组，干预持续3年。3年后，儿童的维生素D缺乏得到纠正，两组的平均25-羟-维生素D水平分别为31.0ng/mL和10.7ng/mL；但是两组间QuantiFERON-TB试验阳性比例没有差异，分别为3.6%和3.3%（P = 0.42）。维生素D组有21名儿童和安慰剂组有25名儿童被诊断患有结核病，分别有29人和34人因急性呼吸道感染住院治疗，发生率无显著差异。结论：维生素D缺乏的儿童中，补充维生素D没有降低结核感染的风险。肺结核的治疗无HIV感染的、成人的药物敏感性的、肺结核治疗：通常2个月强化治疗以及4-7个月维持治疗。强化阶段通常采用四联药物治疗 [ 包括异烟肼、利福霉素类（利福平、利福喷丁、利福布丁）、吡嗪酰胺、乙胺丁醇 ] ，维持治疗通常采用二联药物治疗（包括异烟肼、利福平）。耐药肺结核包括单药耐药和多药耐药。单药耐药的情况下，可选用其他的一线药物，也可联合氟喹诺酮类。多药耐药的治疗取决于药敏试验，原则是尽可能多的一线药物，再加上一种氟喹诺酮类（左氧氟沙星、莫西沙星）和/或另一种核心二线药物（如贝达喹啉、利奈唑胺）。药物研发进展：普托马尼（pretomanid，硝基咪唑嗪类抗菌药，2019年8月批准上市）。《随机研究：短疗程治疗利福平耐药的肺结核的3期临床研究》New England Journal of Medicine，2019年3月 (9)研究的目的是在对氟喹诺酮类和氨基糖苷类药物敏感的、利福平耐药的、结核患者中开展了一项3期非劣效性试验。共424例患者，随机分别接受含有大剂量莫⻄沙星的短疗程方案（9~11个月）或遵循2011年WHO指南推荐的⻓疗程方案（20个月）。132周后，⻓疗程方案组和短疗程方案中，分别有79.8%和78.8%的参与者报告了良好状态（P=0.02）。两组的严重不良事件发生率分别有45.4%和48.2%。短疗程方案组11.0%参与者和⻓疗程方案组6.4%参与者出现QT间期延⻓，并进行了药物调整。结论：在对氟喹诺酮类药物和氨基糖苷类药物敏感的、利福平耐药的结核患者中，包括大剂量莫西沙星的短疗程方案的主要疗效结局不劣于⻓疗程方案，安全性相似。支气管热成型术支气管热成形术（Bronchial Themoplasty）是一种治疗重度哮喘的手段，经由纤维光学支气管镜导入特质的导管，然后利用该导管对支气管壁施加热能，以削弱支气管平滑肌的收缩力、减轻气道平滑肌的增生。该操作通常需要在中度镇静下进行3次支气管镜下操作，每次间隔3周。主要针对的人群是治疗吸入性糖皮质激素和LABA控制不佳的、重症哮喘患者。但这项操作有风险，对其长期的疗效仍有一定的争议。《TASMA研究：支气管热成型术引起的气道平滑肌减少和对重症哮喘的治疗效果》American Journal of Respiratory and Critical Care Medicine，2020年7月(10)研究的目的是确定支气管热成型术对气道平滑肌的质量的影响，并确定哪一类重症哮喘患者适合接受此项治疗。研究纳入40例重症哮喘患者，随机分为即时支气管热成型术组和延迟支气管热成型术组。即时手术组的中位气道平滑肌质量减少>50%，而延迟组的气管平滑肌的质量无变化（p=0.0004）。即时手术组和延迟手术组中，哮喘控制问卷评分分别降低了0.79和升高了0.09（p=0.006）；哮喘生活质量问卷评分分别升高了0.83和降低了0.02（p=0.04）。治疗反应（n=35）与血清IgE和嗜酸性粒细胞呈正相关，但与气道平滑肌基线质量无关。结论：支气管热成型术后气道平滑肌的质量明显降低。疗效与血清IgE和嗜酸性粒细胞水平相关，而与气道平滑肌的质量无关。《随机对照临床研究：129Xe-MRI引导的一次支气管热成形术》American Journal of Respiratory and Critical Care Medicine，2020年8月 (11)不良事件限制了支气管热成形术在重症哮喘中的应用，该研究的目的是使用氙129磁共振技术（129Xe-MRI）引导下进行支气管热成形术。研究对30例严重哮喘患者进行容积CT和129Xe-MRI，以定量节段性通气缺损，然后被随机分组至磁共振引导组（行一次支气管热成形术治疗6个病变最严重的支气管）、或非引导组（标准的三阶段支气管热成形术）。治疗12周后，磁共振引导组与非引导组相比，生活质量评分改善无显著差异（P = 0.201），但肺通气不良和肺不通气的比例下降更显著（-17.2%；P = 0.009）。磁共振引导组中33%的患者术后哮喘加重；非引导组有73%的患者哮喘加重（P = 0.028）。结论：与标准的三次支气管热成形术相比，磁共振引导下的一次支气管热成形术可以取得类似的短期改善，且围手术期不良事件较少。CT诊断人工智能系统《应用人工智能系统对新型冠状病毒肺炎进行CT诊断、定量和预后评估》 Cell，2020年6月 (12)许多罹患COVID-19的患者发展为肺炎，并迅速发展为呼吸衰竭。然而，快速诊断与鉴别高危患者、并早期干预仍十分具有挑战性。使用大型CT数据库分析4154名患者的资料后，研究人员开发了用以诊断和鉴别诊断新型冠状病毒肺炎的人工智能系统。此人工智能系统能够客观、定量的识别和测量新型冠状病毒肺炎病变CT上的肺部损害指标，如小结节、毛玻璃影、实变影，评价疾病严重程度，也可用于客观、定量的评价药物有效性。结合患者临床指标，如吸氧频率、血氧饱和度、血气分析、肝功能、凝血功能等，可以综合分析并预测患者发展为危重症的可能性和时间。参考文献1.Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, et al. 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Joining me on today's show is Dr. Mazn Raouf. And we're going to be discussing and providing insight into the risk of Type two diabetes facing dads. Dr. Mazn is a UK trained doctor with 15 years experience in the NHS. He has a dual certification in by general internal medicine and general practice. Dr. Mazn has a special interest in lifestyle medicine and has recently accomplished the International Board of Lifestyle Medicine and is a member of the American College of Lifestyle Medicine.Support this show http://supporter.acast.com/fitterhealthierdad. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.