Podcasts about blisters

It's the Roland Garros 2025 2nd Round Show... In Thursday's action, Henrique Rocha and Alexander Bublik each pulled off upset wins from down 2-0, against Jakub Mensik and Alex De Minaur Respectively. Joao Fonseca was dominant against Pierre Hughes-Herbert to set up a meeting with Jack Draper, who fended off a fluctuating Gael Monfils. Blisters are the only concern for Novak Djokovic who's tennis was rather blistering against Corentin Moutet. In Wednesday matches, Casper Ruud was effected by injury in a loss to Nuno Borges, Carlos Alcaraz dazzled against Fabian Marozsan, Tommy Paul was tough as his truck in comeback against Marton Fucsovics, Holger Rune put in a disciplined performance against Emilio Nava, and Stefanos Tsitsipas continued his slide with an upset defeat against Mateo Gigante. 0:00 Intro 0:50 Rocha def Mensik 5:05 Bublik def De Minaur 14:20 Fils def Munar 24:00 Fonseca def Herbert 28:00 Draper def Monfils 33:50 Djokovic def Moutet 45:00 Borges def Ruud 48:25 Alcaraz def Marozsan 51:25 Paul def Fucsovics 54:50 Rune def Nava 58:28 Gigante def Tsitsipas Joao Fonseca and Jack Draper are set for a 3rd round blockbuster. Plus, Arthur Fils had to dig deeper than he ever has to beat Jaume Munar. We'll dissect three separate 2-0 comebacks by and Tommy Paul over Marton Fucsovics. IG: https://www.instagram.com/gillgross_/ 24/7 Tennis Community on Discord: https://discord.gg/wW3WPqFTFJ Twitter/X: https://twitter.com/Gill_Gross The Draw newsletter, your one-stop-shop for the best tennis content on the internet every week: https://www.thedraw.tennis/subscribe Become a member to support the channel: https://www.youtube.com/channel/UCvERpLl9dXH09fuNdbyiLQQ/join

I sit down with Kevin Russ—board game designer, iPhone photography legend, thru hiker, and freshly minted Cocodona 250 finisher. We dive into Kevin's wild journey from shooting landscapes with just his phone to creating successful board games, and now, tackling 200+ mile races. He opens up about the physical and mental toll of Cocodona, the moments that tested him most, and the role his crew played in getting him to the finish. We also explore how creativity overlaps with endurance and what's next for Kevin in both ultra running and game design.Check out Kevin on the internet: Website: https://www.kevinruss.com/Instagram: https://www.instagram.com/kevinruss/Check out his board Game: https://amzn.to/3ZpJ0HTSupport our sponsors:Janji.comGaragegrowngear.comCsinstant.coffee00:00 The Rise of an iPhone Photographer04:03 From Photography to Through Hiking06:26 Transitioning to Ultra Running09:19 Preparing for Cocodona 25012:05 Training Challenges and the Chipotle Challenge14:45 Cocodona 250: The Race Begins17:26 Weather Challenges and Mindset Shifts20:23 The Role of Crew and Support22:53 Capturing the Journey on Camera24:14 Navigating Sleep Deprivation26:57 Injuries and Mental Resilience29:18 The Role of Pacers and Crew Support30:27 Facing Challenges in the Final Stretch35:18 Reflections on the Race Experience37:14 Future Plans and Training Insights39:46 Hallucinations and the Nature of Endurance41:09 Underrated Natural Beauty in the U.S.43:04 The Journey into Board Game Design45:48 Launching a Board Game48:28 The Board Game Convention ExperienceSubscribe to Substack: http://freeoutside.substack.comSupport this content on patreon: HTTP://patreon.com/freeoutsideBuy my book "Free Outside" on Amazon: https://amzn.to/39LpoSFEmail me to buy a signed copy of my book, "Free Outside" at jeff@freeoutside.comWatch the movie about setting the record on the Colorado Trail: https://tubitv.com/movies/100019916/free-outsideWebsite: www.Freeoutside.comInstagram: thefreeoutsidefacebook: www.facebook.com/freeoutside

After months of following their journeys, the full crew of Delirious podcast athletes is back for one last episode—together, unfiltered, and full of post-race stories. In this special wrap-up after-party, we reflect on the wild highs, brutal lows, and hilarious moments that defined the 2025 Delirious West 200-miler.   With surprise guest Sean Kaesler (yes, the race director himself!), we dive into: •Favourite trail moments

Send us a textListener Questions Answered: Calories, Tailwind, Sick Days, Blisters & Drop BagsIn this week's Q&A-style episode, I'm tackling some of your most pressing ultra running questions—from fueling on the run to navigating training setbacks, and everything in between. Whether you're dialing in your nutrition or deep in the throes of peak training, this episode is packed with real talk, practical advice, and encouragement for every step of your ultra journey.

Send us a textDr. Jeffrey Hammond, a Podiatrist who specializes in helping long distance athletes, joins the show and dives into the intricacies of foot health, particularly for runners. Jacob, Melody and Jeff discussed common foot issues, the importance of choosing the right shoes, and the ongoing debate between barefoot and cushioned running. Dr. Hammond shares his journey into podiatry and offers valuable insights on injury prevention and effective exercises for runners.Other topics discussed in this conversation was the complexities of running injuries, particularly focusing on when to seek medical advice, the importance of proper footwear, and effective self-care strategies for runners. They discuss common issues such as plantar fasciitis, blisters, and calluses, providing insights on prevention, treatment, and the significance of stretching. Dr. Hammond emphasizes the need for runners to be proactive about their foot health and to seek professional help when necessary, while also encouraging the use of reliable online resources for information.If you have any questions for Jeff, you can find him at the following links.Hammond Foot and Ankle - (801) 377-2274InstagramFacebookIf you would like to support the show with purchasing something from our online store, you can do that HERE!Thank you listening and remember if you want to run 100 miles, MAKE IT HAPPEN!Support the show

Welcome to episode 241 of the Women's Running podcast. I'm your host Esther Newman and she's your other host Holly Taylor. On this podcast we talk about health, politics, stuff on TV and what we ate last night. Occasionally, we talk about running.BlistersWe begin this normally controversy-free podcast to talk to you all about blisters – specifically Holly's blister on her big toe, which is so enormous it has defied the experience of actual medics. So bit of a trigger warning, cos there's a lot of gross foot content ahoy.Lisbon HalfPlus, we've got more on the Lisbon Half from a couple of listeners who also had negative experiences at the Super Half. Do please get in touch with your experience of either this or other races that should be doing better – they'll only get better if we hold them to account, right? Email us at wrpodcast@anthem.co.uk with your thoughts.Inner Circle on PatreonAnd before we forget to mention it, come on to Patreon NOW cos changes are afoot. From this week, you can join our official Inner Circle for just £6 to shape what we talk about, and to hear about the Big Exciting Thing that we're doing in March 2026 first. And from there, jump into Discord to talk about it all with a bunch of lovely women who support each other and our running. It's ace! Go to patreon.com/womensrunnning to find out more.Lovely extra bitsThis episode is sponsored by Coopah. Coopah are offering all pod squadders a 2-week free trial of their app and then giving 20% off their standard annual subscription price. Just download the Coopah app and use the code WOMENSRUNNING when you sign up. Or visit coopah.com/womensrunning where you can find all of these details.We picked up our lovely hotel rooms through Marathon Tours: you can pick up hotel rooms for the Marathon here: TCS London Marathon 2025 | Marathon Tours & Travel UKDo also check them out if you're eyeing up one of the other marathon majors.@marathontours_uk on Instagram ·      Subscribe to Women's Running – and you'll save 50%Setting up your own podcast? Try Zencastr – we've been using it for ages and LOVE ITDownload a FREE mini mag to help you run 5K! Go to womensrunning.co.uk/runBuy a Pod Squad t-shirt!Do join us on Patreon so you can come and chat in our new Pod Squad community on Discord! Go to patreon.co.uk/womensrunningEmail us at wrpodcast@anthem.co.uk with any questions or running stories Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

Welcome to episode 241 of the Women's Running podcast. I'm your host Esther Newman and she's your other host Holly Taylor. On this podcast we talk about health, politics, stuff on TV and what we ate last night. Occasionally, we talk about running.BlistersWe begin this normally controversy-free podcast to talk to you all about blisters – specifically Holly's blister on her big toe, which is so enormous it has defied the experience of actual medics. So bit of a trigger warning, cos there's a lot of gross foot content ahoy.Lisbon HalfPlus, we've got more on the Lisbon Half from a couple of listeners who also had negative experiences at the Super Half. Do please get in touch with your experience of either this or other races that should be doing better – they'll only get better if we hold them to account, right? Email us at wrpodcast@anthem.co.uk with your thoughts.Inner Circle on PatreonAnd before we forget to mention it, come on to Patreon NOW cos changes are afoot. From this week, you can join our official Inner Circle for just £6 to shape what we talk about, and to hear about the Big Exciting Thing that we're doing in March 2026 first. And from there, jump into Discord to talk about it all with a bunch of lovely women who support each other and our running. It's ace! Go to patreon.com/womensrunnning to find out more.Lovely extra bitsThis episode is sponsored by Coopah. Coopah are offering all pod squadders a 2-week free trial of their app and then giving 20% off their standard annual subscription price. Just download the Coopah app and use the code WOMENSRUNNING when you sign up. Or visit coopah.com/womensrunning where you can find all of these details.We picked up our lovely hotel rooms through Marathon Tours: you can pick up hotel rooms for the Marathon here: TCS London Marathon 2025 | Marathon Tours & Travel UKDo also check them out if you're eyeing up one of the other marathon majors.@marathontours_uk on Instagram ·      Subscribe to Women's Running – and you'll save 50%Setting up your own podcast? Try Zencastr – we've been using it for ages and LOVE ITDownload a FREE mini mag to help you run 5K! Go to womensrunning.co.uk/runBuy a Pod Squad t-shirt!Do join us on Patreon so you can come and chat in our new Pod Squad community on Discord! Go to patreon.co.uk/womensrunningEmail us at wrpodcast@anthem.co.uk with any questions or running stories Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

Hi Everyone! Welcome back to another episode of LMN. In this episode we cover the following:- Indian Wells Ground Pass- Vacation Photos- Draper's Big Win and Room for Improvement- Andreeva Indian Wells Winner- Early Losses in Miami- Anisomova Blister Controversy- Online Hate Directed at Mirra Andreeva- Alcaraz Inconsistency - Djokovic Opening at Miami- Snow White Wokeness- White Lotus - Tiger Goes Public with Trump- Good Good Golf Raises $45M- Tennis Fans Need to Figure it Out

Rennae and Caitlin attempt to break down the well-intentioned? Ill-intentioned? obvious yet nonsensical? PTPA lawsuit filed against both tours as well as clear up the rules about acute injuries, discuss the Raducanussaince and give some deserved guff to the tournament organizers.See omnystudio.com/listener for privacy information.

Most runners inevitably deal with these minor issues - blisters, black toenails, chafing, and more. They aren't full injuries, but they certainly are inconvenient and uncomfortable. We guide you through how to prevent these, how to treat them, and if you can run through them when they happen.  In this episode, you'll learn how to deal with:Calf crampsBlistersChafingBlack toenailsNumb toes during a runRed and itchy legs while runningSide stitchesSunburnsResources:https://runtothefinish.com/how-to-lace-running-shoes/https://lauranorrisrunning.com/running-cramps/https://lauranorrisrunning.com/how-to-breathe-while-running/https://runtothefinish.com/altra-vs-topoThis episode is sponsored by Previnex! Previnex creates clinically effective supplements made with high-quality ingredients. Their probiotic provides 30 million CFUS with six bacteria strains - and unlike other brands, their probiotic works! Use the code treadlightly for 15% off your first order at previnex.com.Join us on Patreon at https://www.patreon.com/TreadLightlyRunningReferences: PMID: 34185846PMID: 31696455PMID: 25178498

How should you go about managing and preventing blisters, and what workout is going to be best for you. This listener Q&A dives into these two topics. Endurance Training Simplified Series Zach's Low Carb Endurance Approach Series LMNT: drinkLMNT.com/HPO (free sample pack with purchase) deltaG: deltagketones.com Code: BITTER20 Maui Nui Venison: mauinuivenison.com Support HPO: zachbitter.com/hposponsors HPO Website: zachbitter.com/hpo  Amazon Store: amazon.com/shop/zachbitter Zach's Coaching: zachbitter.com/coaching Zach's Newsletter: substack.com/@zachbitter Find Zach: zachbitter.com - IG: @zachbitter - X/Tw: @zbitter - FB: @zbitterendurance - Strava: Zach Bitter

What to carry in my first aid bag.Leuko tape- Blisters and hot spotsBand-Aids Bandanna Tweezers Small knife Benadryl Ibuprofen Antibacterial cream Allergy and medication list

Siblings Ashley Engle and Brandon Birdwell discuss life, Christmas blisters, Zack Attack, Ashley's trip to Mexico and Brandon's trip to Medieval Times.

Race day is finally here, and while it's your time to shine, it can also be full of unexpected twists and turns. From forgotten shoes to mid-race cramps, I've seen it all—and I've coached runners through it all. In this episode of Extraordinary Strides, I'm sharing the ultimate race day survival guide packed with practical tips, humorous anecdotes, and heartfelt encouragement.We'll dive into how to avoid common mishaps, like showing up late or overdressing, and tackle what to do when things go sideways—because let's face it, sometimes they will. Whether it's a blister at mile ten or the dreaded porta-potty dilemma, you'll leave this episode ready to handle anything the race throws at you. Tune in for wisdom, laughter, and the confidence boost you need to crush your next race.Your Fairy Runmother has you covered—now, let's stride toward extraordinary together!

The Pirates discuss the Susan G. Komen 60 Mile Walk in Dallas, Texas... the good, the bad and the ugly.  Spoiler Alert: The Pirates already signed up to do the 60 mile walk again in 2025 - this time in Boston on August 15-17. Additional walkers are encouraged to join the Pink Pirate Team (links to sign up are below). Please use referral link on the specific pages to sign up, as that contributes to the overall fundraising amount! Or reach out to the Pirates individually to discuss participating and/or how to sign up. Donations can be submitted at any of the links below, as well.  On behalf of all the Pink Pirate team members, we cannot thank you enough for your support!  Shawna's page (to donate or sign up to walk) -   https://www.the3day.org/site/TR/2024/20253Day?px=8306872&pg=personal&fr_id=2322 Adrienne's page (to donate or sign up to walk) - https://www.the3day.org/site/TRR/2024/20253Day/442494270?pg=ptype&fr_id=2322 Denise's page (to donate or sign up to walk)  - https://www.the3day.org/site/TRR/2024/20253Day/32232820?pg=ptype&fr_id=2322    

Join Aaron, Richard, and Chase as they dive into the perils of season 2 of Arcane. Beast-men, prison breaks, godly machines, and Aaron's theft of Chase's intellectual property are all in store.Contact UsQuestions or comments? Visit thelorehounds.com, where you can use the contact form or the voicemail feature. Or, send us an email to radioactive@thelorehounds.comJoin the conversation on DiscordANDfollow us on Bluesky @Radioactive141For early and ad-free content as well as exclusive episodes, check out our brand new Patreon!Check out the podcasts we are affiliated with:The LorehoundsRings & RitualsSeverance PodcastWool-Shift-DustThe Star Wars Canon Timeline PodcastProperly Howard Movie ReviewsNevermind the MusicAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Tiffany Gil, the CEO and inventor behind Shezza Socks, creates foam-padded socks designed to prevent blisters. Tiffany's journey to entrepreneurship started as a high schooler struggling with painful blisters from new shoes. After years of refining her idea and overcoming challenges—like securing funding by winning a cross-country lawnmower race—Tiffany's product went viral on TikTok. This led Tiffany to pitch her brand on the Buy It Now show, where she impressed a panel of judges, including Jamie Siminoff (founder of Ring) and celebrity entrepreneur Gwyneth Paltrow. You can watch Shezza Socks' episode on the Buy it Now show titled: The Panel Get Grilled. Tune in and get inspired by the real stories behind the entrepreneurs and products featured on Buy It Now. You can find winning products on the Buy It Now Store. Follow TISB: Behind the Buy on Spotify, Apple Podcasts, or wherever you get your podcasts and make sure to watch Buy It Now on Prime Video. In this episode you'll discover: (0:07) How Tiffany solved a personal problem. Tiffany created Shezza Socks after struggling with painful blisters from new shoes, turning a personal issue into a business idea.(5:55) Tiffany funded her business by winning a lawnmower race and entering pitch competitions, showing the value of persistence and resourcefulness.(7:59) How Tiffany leveraged social media to gain entrepreneurial recognition. A viral TikTok video helped Shezza Socks gain traction, demonstrating the power of social media for marketing.(14:10) The importance of valuing and embracing feedback. Tiffany received valuable feedback on her brand name from industry leaders, showing the importance of being open to criticism and adapting.

Welcome to Show Boys, a podcast that delves into the world of film, tv and gaming. In this week's episode, Nick, Mike and Show Boys community member Venom sit down and recap Episode 5, Blisters and Bedrock! Arcane Season 1 Steelbook Giveaway Rules: - 1 entry for being subscribed to our channel (make sure your subscription settings are set to public so we can see you are subscribed) - 1 entry for commenting on the video (limit of 1 additional entry for your first comment). - Winner will be picked during the Season 2 finale episode - good luck!! Patreon Link: https://www.patreon.com/showboyspodcast Catch reruns of our massive backlog of content over on Twitch: https://www.twitch.tv/showboyspodcast Follow PokéBoys on Twitter: https://twitter.com/PokeBoysPodcast Visit our website for everything Show Boys related! https://showboysmedia.com/ Come for the podcast, stay for the community. Join our discord today! https://discord.gg/gPqSu7QmnQ Interested in supporting the podcast? Visit our Patreon page and sign up to become a Patron for some cool perks, or toss us a bone on Venmo @Show-Boys! Merch Shop! https://my-store-be6562.creator-spring.com/ Like what you hear? Let us know in the comments and please consider subscribing!

VIOLET RETURNS!! Arcane Season 2 Act 2 "Blisters and Bedrock" Full Reaction Watch Along:  https://www.patreon.com/thereelrejects Download the PrizePicks today & use code REJECTS to $50 instantly when you play $5! https://prizepicks.onelink.me/LME0/RE... Follow Us On Socials:  Instagram: https://www.instagram.com/reelrejects/  Tik-Tok: https://www.tiktok.com/@thereelrejects?lang=en Twitter: https://x.com/thereelrejects Facebook: https://www.facebook.com/TheReelRejects/ Arcane Season 2 Reaction, Recap, Commentary, Analysis, Spoiler Review, Breakdown, & Ending Explained! Jinx becomes a symbol for the undercity as Isha takes on more of the mantle, leading to the ultimate prison breakout. Arcane Season 2 is from the the hit Netflix series adapted from Riot Games' League of Legends. Picking up immediately where the first season left off, Arcane Season 2, Act 2 continues the story of wayward sisters, Vi & Jinx (True Grit / Hawkeye / Across the Spider-Verse's Hailee Steinfeld & Fall out / Yellowjackets / Army of the Dead's Ella Purnell) along with the ever-ranging conflict between the privileged nation of Piltover and the oppressed & burgeoning nation of Zaun...   Greg & John REACT to the Best Scenes & Most Exciting Moments as we make our way through Part 1 of season 2 and anticipate what could be coming in Parts 2 and 3... How will the series end?!? Support The Channel By Getting Some REEL REJECTS Apparel! https://www.rejectnationshop.com/ Music Used In Manscaped Ad:  Hat the Jazz by Twin Musicom is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ POWERED BY @GFUEL Visit https://gfuel.ly/3wD5Ygo and use code REJECTNATION for 20% off select tubs!! Head Editor: https://www.instagram.com/praperhq/?hl=en Co-Editor: Greg Alba Co-Editor: John Humphrey Music In Video: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Ask Us A QUESTION On CAMEO: https://www.cameo.com/thereelrejects Follow TheReelRejects On FACEBOOK, TWITTER, & INSTAGRAM:  FB:  https://www.facebook.com/TheReelRejects/ INSTAGRAM:  https://www.instagram.com/reelrejects/ TWITTER:  https://twitter.com/thereelrejects Follow GREG ON INSTAGRAM & TWITTER: INSTAGRAM:  https://www.instagram.com/thegregalba/ TWITTER:  https://twitter.com/thegregalba Learn more about your ad choices. Visit megaphone.fm/adchoices

Originally aired on November 12, 2024: We dug up some pretty Unfun Facts about STDs. Plus, you and your mom probably share a pretty personal number. The Rock will admit to taking a leak in a bottle, but not being late... See omnystudio.com/listener for privacy information.

Election, Blisters, No Longer Human and more! 選挙、水ぶくれ、人間失格など！ Join our Book Club! https://ko-fi.com/i/IK3K315PT27 Support on ko-fi: https://ko-fi.com/lazyfluency Main channel: https://www.youtube.com/channel/UC-8_djC5_aV4Mi3o3fuLPLA/featured Send us questions at: lazyfluency@gmail.com  

Camino De Santiago: Kevin Scampoli tells us about. his upcoming journey as a "pilgrim" of the Camino De Santiago. Geno: With Kevin in studio, we get a call from Geno to bask in the brotherly love and apologize for spoiling Barbarian. AI Suicide: A teenager fell in love with an AI Daenerys Targaryen which resulted in his suicide. MAKING THE BEAT!, HIGH HAT!, INTRO!, THRILLER!, MICHAEL JACKSON!, LOFT BOYS!, TESTIFY!, VOCALS!, COACH!, CAMINO DE SANTIAGO!, NORMIE!, TRAIL!, HIKE!, EUROPE!, FRANCE!, INTROSPECTIVE!, 1,000 KM!, HOSTELS!, COMMUNES!, WAYPOINTS!, SPAIN!, LOST FAMILY!, NOTHING TO LIVE FOR!, DUAL CITIZENSHIP!, ITALY!, EUROPE!, KOSOVO!, SAUDI ARABIA!, OSAKA!, STEPS!, BLISTERS!, GPS!, APP!, DOWNSIZING!, DECLUTTERING!, GET RID OF EVERYTHING!, HIKING!, BACKPACK!, WEIGHT!, HARVY DAVIDSON!, HARLEY DAVIDSON!, CRYING!, LIEUTENANT DAN!, EMILIO ESTEVEZ!, MARTIN SHEEN!, THE WAY!, SWAMP OF SADNESS!, ATRAX!, STAMPS!, COMPESTELA!, DON'T KNOW WHAT YOU GOT UNTIL IT'S GONE!, TAKE THINGS FOR GRANTED!, DISCONNECTED!, THANKSGIVING!, CHRISTMAS!, CRY FOR HELP!, HEADPHONES!, BLUETOOTH SPEAKER!, FALLOUT BOY!, LIGHT EM UP!, STAND UP!, SCENERY VIDEOS!, ASMR!, BUCA DI BEPPO!, CRYING!, MAULY NEEDS A HOME!, DOG!, GENO!, BARBARIAN!, SPOILERS!, SYMPATHY!, ISRAEL!, TRANS!, WILL OSPREAY!, RICOCHET!, SHAWN MICHAELS!, WRESTLEMANIA 14!, AI CHARACTERS!, DAENERYS TARGARYEN!, ROMANCE!, SUICIDE!, 14 YEAR OLD!, SIREN! SURVIVE THE ISLAND!, KOREAN!  You can find the videos from this episode at our Discord RIGHT HERE!

Whatcha been playing? Email the show / Leave us a Speakpipe / Discord Channel / Patreon Page   PMGB: Inscryption Next week: Blops 6 Stu  Silent Hill 2 Remake The Precinct Star Vaders Inscryption Duke RL / New World: Aeternum Ballionaire Demo CoD: Black Ops 6 House Flipper 2 Prospector: First Contract Chinny Inscryption Super Mario Sunshine Alan Wake 2

We have a very special 100th episode for you all! John Solberg, Weatherby's Strategic Accounts Manager, drew a once-in-a-lifetime Bison tag here in the state of Wyoming. In mid-september John and the Solberg family packed up the trailer and headed to the Grand Tetons and the adventure they had was nothing short of extraordinary! Luke and Tyler sit down with John, his brother, and Social Media Specialist/Cameraman DJ Dean to discuss the adventure and how they ended up doubling up on bison with another hunter! In this episode we discuss: - Drawing the tag - Preparing and packing - Highs and lows of the hunt - Blisters and cramps - Day by day breakdown - The legendary Bob Lightfoot - Moments leading up to the shot - Doubling up with Bob - The packout - Black bears, Grizzly bears, and Bison Connect with Weatherby! Instagram: https://www.instagram.com/weatherbyinc/ Facebook: https://www.facebook.com/Weatherbyinc/ Follow our shotgun page! Instagram: https://www.instagram.com/wbyfieldandflight/ Facebook: https://www.facebook.com/WBYfieldandflight

Pretty much as advertised. Also some USMNT talk and a NLD preview.

Pharmacogenomics plays a critical role in personalised medicine, as some adverse drug reactions are genetically determined. Adverse drugs reactions (ADRs) account for 6.5% of hospital admissions in the UK, and the application of pharmacogenomics to look at an individuals response to drugs can significantly enhance patient outcomes and safety. In this episode, our guests discuss how genomic testing can identify patients who will respond to medications and those who may have adverse reactions. We hear more about Genomics England's collaboration with the Medicines and Healthcare products Regulatory Agency in the Yellow Card Biobank and our guests discuss the challenges of implementing pharmacogenomics into the healthcare system. Our host Vivienne Parry, Head of Public Engagement at Genomics England, is joined by Anita Hanson, Research Matron and the Lead Research Nurse for clinical pharmacology at Liverpool University Hospitals NHS Foundation Trust, and Professor Bill Newman, Professor of translational genomic medicine at the Manchester Center for Genomic Medicine, and Professor Matt Brown, Chief Scientific Officer at Genomics England.   "I think we're moving to a place where, rather than just doing that one test that might be relevant to one drug, we'd be able to do a test which at the same price would generate information that could be relevant at further points in your life if you were requiring different types of medicine. So, that information would then be available in your hospital record, in your GP record, that you could have access to it yourself. And then I think ultimately what we would really love to get to a point is where everybody across the whole population just has that information to hand when it's required, so that they're not waiting for the results of a genetic test, it's immediately within their healthcare record."   To learn more about Jane's lived experience with Stevens-Johnson syndrome, visit The Academy of Medical Sciences' (AMS) YouTube channel. The story, co-produced by Areeba Hanif from AMS, provides an in-depth look at Jane's journey. You can watch the video via this link: https://www.youtube.com/watch?v=v4KJtDZJyaA  Want to learn more about personalised medicine? Listen to our Genomics 101 episode where Professor Matt Brown explains what it is in less than 5 minutes: https://www.genomicsengland.co.uk/podcasts/genomics-101-what-is-personalised-medicine  You can read the transcript below or download it here: https://www.genomicsengland.co.uk/assets/documents/Podcast-transcripts/Can-genomic-testing-prevent-adverse-drug-reactions.docx   Vivienne: Hello and welcome to Behind the Genes.  Bill: What we've seen is that the limited adoption so far in the UK and other countries has focused particularly on severe adverse drug reactions. They've been easier to identify and there's a clear relationship between some drugs and some genetic changes where that information is useful. So, a good example has been the recent adoption of pharmacogenetic testing for a gene called DPYD for patients undergoing cancer treatment, particularly breast and bowel cancer. And if you have an absence of the enzyme that that gene makes, if you're given that treatment, then you can end up on intensive care and die, so it's a really significant side effect. But as you say, the most common side effects aren't necessarily fatal, but they can have a huge impact upon people and on their wellbeing.  Vivienne: My name's Vivienne Parry and I'm head of public engagement at Genomics England, and today we'll be discussing the critical role of pharmacogenomics in personalised medicine, highlighting its impact on how well medicines work, their safety, and on patient care. I'm joined today by Professor Bill Newman, professor of translational genomic medicine at the Manchester Centre for Genomic Medicine, Anita Hanson, research matron, a fabulous title, and lead research nurse for clinical pharmacology at the Liverpool University Hospital's NHS Foundation Trust, and Professor Matt Brown, chief scientific officer for Genomics England. And just remember, if you enjoy today's episode, we'd love your support, so please like, share and rate us on wherever you listen to your podcasts.  So, first question to you, Bill, what is pharmacogenomics?  Bill: Thanks Viv. I think there are lots of different definitions, but how I think of pharmacogenetics is by using genetic information to inform how we prescribe drugs, so that they can be safer and more effective. And we're talking about genetic changes that are passed down through families, so these are changes that are found in lots of individuals. We all carry changes in our genes that are important in how we transform and metabolise medicines, and how our bodies respond to them.  Vivienne: Now, you said pharmacogenetics. Is it one of those medicine things like tomato, tomato, or is there a real difference between pharmacogenetics and pharmacogenomics?  Bill: So, people, as you can imagine, do get quite irate about this sort of thing, and there are lots of people that would contest that there is a really big important difference. I suppose that pharmacogenetics is more when you're looking at single changes in a relatively small number of genes, whereas pharmacogenomics is a broader definition, which can involve looking at the whole genome, lots of genes, and also whether those genes are switched on or switched off, so the expression levels of those genes as well would encompass pharmacogenomics. But ultimately it's using genetic information to make drug prescription safer and more effective.  Vivienne: So, we're going to call it pharmacogenomics and we're talking about everything, that's it, we'll go for it. So Matt, just explain if you would the link between pharmacogenomics and personalised medicine. And I know that you've done a big Genomics 101 episode about personalised medicine, but just very briefly, what's the link between the two?  Matt: So, personalised medicine's about using the right dose of the right drug for the right individual. And so pharmacogenomics helps you with not only ensuring that you give a medication which doesn't cause problems for the person who receives it, so an adverse drug reaction, but also that they're actually getting the right dose. Of course, people's ability to metabolise, activate and respond to drugs genetically is often genetically determined, and so sometimes you need to adjust the dose up or down according to a person's genetic background.  Vivienne: Now, one of the things that we've become very aware of is adverse drug reactions, and I think they account for something like six and a half percent of all hospital admissions in the UK, so it's absolutely huge. Is that genetically determined adverse drug reactions?  Matt: So, the answer to that is we believe so. There's quite a bit of data to show that you can reduce the risk of people needing a hospital admission by screening genetic markers, and a lot of the very severe reactions that lead to people being admitted to hospital are very strongly genetically determined. So for example, there are HLA types that affect the risk of adverse drug reactions to commonly used medications for gout, for epilepsy, some HIV medications and so on, where in many health services around the world, including in England, there are already tests available to help prevent those leading to severe reactions. It's likely though that actually the tests we have available only represent a small fraction of the total preventable adverse drug reactions were we to have a formal pre-emptive pharmacogenomics screening programme.  Vivienne: Now, I should say that not all adverse drug reactions are genetic in origin. I mean, I remember a rather nasty incident on the night when I got my exam results for my finals, and I'd actually had a big bee sting and I'd been prescribed antihistamines, and I went out and I drank rather a lot to celebrate, and oh my goodness me, I was rather ill [laughter]. So, you know, not all adverse drug reactions are genetic in origin. There are other things that interact as well, just to make that clear to people.  Matt: Yes, I think that's more an interaction than an adverse drug reaction. In fact frankly, the most common adverse drug reaction in hospitals is probably through excess amounts of water, and that's not medically determined, that's the prescription.  Vivienne: Let me now come to Anita. So, you talk to patients all the time about pharmacogenomics in your role. You've been very much involved in patient and public involvement groups at the Wolfson Centre for Personalised Medicine in Liverpool. What do patients think about pharmacogenomics? Is it something they welcome?  Anita: I think they do welcome pharmacogenomics, especially so with some of the patients who've experienced some of the more serious, life threatening reactions. And so one of our patients has been doing some work with the Academy of Medical Sciences, and she presented to the Sir Colin Dollery lecture in 2022, and she shared her story of having an adverse drug reaction and the importance of pharmacogenomics, and the impact that pharmacogenomics can have on patient care.  Vivienne: Now, I think that was Stevens-Johnson syndrome. We're going to hear in a moment from somebody who did experience Stevens-Johnson's, but just tell us briefly what that is.  Anita: Stevens-Johnson syndrome is a potentially life threatening reaction that can be caused by a viral infection, but is more commonly caused by a medicine. There are certain groups of medicines that can cause this reaction, such as antibiotics or anticonvulsants, nonsteroidal anti-inflammatories, and also a drug called allopurinol, which is used to treat gout. Patients have really serious side effects to this condition, and they're often left with long-term health complications. The morbidity and mortality is considerable as well, and patients often spend a lot of time in hospital and take a long time to recover.   Vivienne: And let's now hear from Jane Burns for someone with lived experience of that Stevens-Johnson syndrome. When Jane Burns was 19, the medicine she took for her epilepsy was changed.  Jane: I remember waking up and feeling really hot, and I was hallucinating, so I was taken to the Royal Liverpool Hospital emergency department by my parents. When I reached A&E, I had a temperature of 40 degrees Celsius. I was given Piriton and paracetamol, and the dermatologist was contacted. My mum had taken my medication to hospital and explained the changeover process with my epilepsy medication. A decision was made to discontinue the Tegretol and I was kept in for observation. Quite rapidly, the rash was changing. Blisters were forming all over my body, my mouth was sore and my jaw ached. My temperature remained very high. It was at this point that Stevens-Johnson syndrome, or SJS, was diagnosed.  Over the next few days, my condition deteriorated rapidly. The rash became deeper in colour. Some of the blisters had burst, but some got larger. I developed ulcers on my mouth and it was extremely painful. I started to lose my hair and my fingernails. As I had now lost 65 percent of my skin, a diagnosis of toxic epidermal necrolysis, or TEN, was made. Survivors of SJS TEN often suffer with long-term visible physical complications, but it is important to also be aware of the psychological effects, with some patients experiencing post-traumatic stress disorder. It's only as I get older that I realise how extremely lucky I am to have survived. Due to medical and nursing expertise, and the research being conducted at the time, my SJS was diagnosed quickly and the medication stopped. This undoubtedly saved my life.  Vivienne: Now, you've been looking at the development of a passport in collaborating with the AMS and the MHRA. Tell me a bit more about that.  Anita: Yes, we set up a patient group at the Wolfson Centre for Personalised Medicine approximately 12 years ago, and Professor Sir Munir Pirmohamed and I, we wanted to explore a little bit more about what was important to patients, really to complement all the scientific and clinical research activity within pharmacogenomics. And patients recognised that, alongside the pharmacogenomic testing, they recognised healthcare professionals didn't really have an awareness of such serious reactions like Stevens-Johnson syndrome, and so they said they would benefit from having a My SJS Passport, which is a booklet that can summarise all of the important information about their care post-discharge, and this can then be used to coordinate and manage their long-term healthcare problems post-discharge and beyond. And so this was designed by survivors for survivors, and it was then evaluated as part of my PhD, and the findings from the work suggest that the passport is like the patient's voice, and it really does kind of validate their diagnosis and raises awareness of SJS amongst healthcare professionals. So, really excellent findings from the research, and the patients think it's a wonderful benefit to them.  Vivienne: So, it's a bit like a kind of paper version of the bracelet that you sometimes see people wearing that are on steroids, for instance.  Anita: It is like that, and it's wonderful because it's a handheld source of valuable information that they can share with healthcare professionals. And this is particularly important if they're admitted in an emergency and they can't speak for themselves. And so the passport has all that valuable information, so that patients aren't prescribed that drug again, so it prevents them experiencing a serious adverse drug reaction again.   Vivienne: So, Stevens-Johnson, Bill, is a really scary side effect, but what about the day to day benefits of pharmacogenomics for patients?  Bill: So, what we've seen is that the limited adoption so far in the UK and other countries has focused particularly on severe adverse drug reactions. They've been easier to identify and there's a clear relationship between some drugs and some genetic changes where that information is useful. So a good example has been the recent adoption of pharmacogenetic testing for a gene called DPYD for patients undergoing cancer treatment, particularly breast and bowel cancer. And if you have an absence of the enzyme that that gene makes, if you're given that treatment, then you can end up on intensive care and die, so it's a really significant side effect. But as you say, the most common side effects aren't necessarily fatal, but they can have a huge impact upon people and on their wellbeing.   And it's not just in terms of side effects. It's in terms of the effectiveness of the medicine. Because if a person is prescribed a medicine that doesn't or isn't going to work for them then it can take them longer to recover, to get onto the right medicine. That can have all sorts of detrimental effects. And so when we're thinking about introducing pharmacogenetics more broadly rather than just on a single drug or a single gene basis, we're thinking about that for common drugs like antidepressants, painkillers, statins, the drugs that GPs are often prescribing on a regular basis to a whole range of patients.  Vivienne: So, to go back to you, Anita, we're really talking about dose here, aren't we, whether you need twice the dose or half the dose depending on how quickly your body metabolises that particular medicine. How do patients view that?  Anita: Well, the patient in question who presented for the Academy of Medical Sciences, I mean, her take on this was, she thinks pharmacogenetics is wonderful because it will allow doctors and nurses to then prescribe the right drug, but also to adapt the dose accordingly to make sure that they get the best outcome, which provides the maximum benefit while also minimising any potential harm. And so from her perspective, that was one of the real benefits of pharmacogenomics. But she also highlighted about the benefits for future generations, the fear of her son taking the same medicine and experiencing the same reaction. And so I think her concerns were, if we have pharmacogenetic testing for a panel of medicines, as Bill mentioned then, then perhaps this would be fantastic for our children as they grow up, and we can identify and predict and prevent these type of reactions happening to future generations.  Vivienne: And some of these drugs, Bill, are really very common indeed, something like codeine. Just tell us about codeine, ‘cos it's something – whenever I tell this to friends [laughter], they're always completely entranced by the idea that some people don't need nearly as much codeine as others.  Bill: Yeah, so codeine is a drug that's very commonly used as a painkiller. To have its real effect, it needs to be converted in the body to a different drug called morphine, and that is done by an enzyme which is made by a gene called CYP2D6. And we all carry changes in CYP2D6, and the frequency of those variants, whether they make the gene work too much or whether they make it work too little, they vary enormously across the world, so that if you go to parts of Africa, about 30 percent of the population will make more of the CYP2D6, and so they will convert the codeine much more quickly, whereas if you go to the UK, maybe up to ten percent of the white population in the UK just won't be converting codeine to morphine at all, so they won't get any benefit from the drug. So at both ends, you have some people that don't respond and some people that respond a little bit too much so that they need either an alternative drug or they need a different dose.  Vivienne: So, all those people who say, you know, “My headache hasn't been touched by this painkiller,” and we say, “What a wimp you're being,” actually, it's to do with genetics.  Bill: Yeah, absolutely. There's a biological reason why people don't – not for everybody, but for a significant number of people, that's absolutely right, and we can be far more tailored in how we prescribe medication, and get people onto painkillers that work for them much more quickly.  Vivienne: And that's so interesting that it varies by where you come from in the world, because that means we need to give particular attention – and I'm thinking, Anita, to working with patients from different community groups, to make sure that they understand the need for pharmacogenomics.  Anita: I think that's really important, Vivienne, and I think we are now having discussions with the likes of Canada SJS awareness group, and also people have been in touch with me from South Africa because people have requested the passport now to be used in different countries, because they think it's a wonderful tool, and it's about raising awareness of pharmacogenomics and the potential benefits of that, and being able to share the tools that we've got to help patients once they've experienced a serious reaction.  Vivienne: So, pharmacogenomics clearly is important in the prevention of adverse drug reactions, better and more accurate prescribing, reduced medicines wastage. Does this mean that it's also going to save money, Bill, for the NHS?  Bill: Potentially. It should do if it's applied properly, but there's lots of work to make sure that not only are we using the right evidence and using the right types of tests in the laboratory, but we're getting the information to prescribers, so to GPs, to pharmacists, to hospital doctors, in a way that is understandable and meaningful, such that they can then act upon that information. So, the money will only be saved and then can be reused for healthcare if the whole process and the whole pathway works, and that information is used effectively.  Vivienne: So, a lot of research to make sure that all of that is in place, and to demonstrate the potential cost savings.  Bill: Yes. I mean, there are very nice studies that have been done already in parts of the world that have shown that the savings that could be accrued for applying pharmacogenetics across common conditions like depression, like in patients to prevent secondary types of strokes, are enormous. They run into hundreds of millions of pounds or dollars. But there is an initial investment that is required to make sure that we have the testing in place, that we have the digital pathways to move the information in place, and that there's the education and training, so that health professionals know how to use the information. But the potential is absolutely enormous.  Vivienne: Matt, can I turn now to the yellow card. So, people will be very familiar with the yellow card system. So, if you have an adverse reaction, you can send a yellow card in – I mean, literally, it is a yellow card [laughter]. It does exactly what it says on the tin. You send a yellow card to the MHRA, and they note if there's been an adverse effect of a particular medicine. But Genomics England is teaming up with the MHRA to do something more with yellow cards, and we're also doing this with the Yellow Card Biobank. Tell us a bit more.  Matt: So, yellow card's a great scheme that was set up decades ago, initially starting off, as you said, with literally yellow cards, but now actually most submissions actually come online. And it's important to note that submissions can come not just from healthcare providers, but majority of submissions actually come from patients themselves, and that people should feel free, if they feel they've had an adverse drug reaction, to report that themselves rather than necessarily depending on a medical practitioner or the healthcare provider to create that report. So, Genomics England is partnering with the MHRA in building what's called the Yellow Card Biobank, the goal of which is to identify genetic markers for adverse drug reactions earlier than has occurred in the past, so that we can then introduce genetic tests to prevent these adverse drug reactions much sooner than has occurred previously.   So, what we're doing is basically at the moment we're doing a pilot, but the ultimate plan is that in future, patients who report a serious adverse drug reaction through the Yellow Card Biobank will be asked to provide a sample, a blood sample, that we then screen. We do a whole genome sequence on it, and then combine these with patients who've had like adverse drug reactions and identify genetic markers for that adverse drug reaction medication earlier, that can then be introduced into clinical practice earlier. And this should reduce by decades the amount of time between when adverse drug reactions first start occurring with medications and us then being able to translate that into a preventative mechanism.  Vivienne: And will that scheme discover, do you think, new interactions that you didn't know about before? Or do you expect it to turn up what you already know about?  Matt: No, I really think there's a lot of discovery that is yet to happen here. In particular, even for drugs that we know cause adverse drug reactions, mostly they've only been studied in people of European ancestry and often in East Asian ancestry, but in many other ancestries that are really important in the global population and in the UK population, like African ancestry and South Asian ancestries, we have very little data. And even within Africa, which is an area which is genetically diverse as the rest of the world put together, we really don't know what different ethnicities within Africa, actually what their genetic background is with regard to adverse drug reactions.  The other thing I'd say is that there are a lot of new medications which have simply not been studied well enough. And lastly, that at the moment people are focused on adverse drug reactions being due to single genetic variants, when we know from the model of most human diseases that most human diseases are actually caused by combinations of genetic variants interacting with one another, so-called common disease type genetics, and that probably is similarly important with regard to pharmacogenomics as it is to overall human diseases. That is, it's far more common that these are actually due to common variants interacting with one another rather than the rare variants that we've been studying to date.  Vivienne: So, it's a kind of cocktail effect, if you like. You know, you need lots of genes working together and that will produce a reaction that you may not have expected if you'd looked at a single gene alone.  Matt: That's absolutely correct, and there's an increasing amount of evidence to show that that is the case with medications, but it's really very early days for research in that field. And the Yellow Card Biobank will be one of many approaches that will discover these genetic variants in years to come.  Vivienne: Now, Matt's a research scientist. Bill, you're on the frontline in the NHS. How quickly can this sort of finding be translated into care for people in the NHS?  Bill: So, really quickly is the simple answer to that, Viv. If we look at examples from a number of years ago, there's a drug called azathioprine that Matt has used lots in some of his patients. In rheumatology, it's used for patients with inflammatory bowel disease. And the first studies that showed that there was a gene that was relevant to having bad reactions to that drug came out in the 1980s, but it wasn't until well into this century, so probably 30-plus years later that we were routinely using that test in clinical medicine. So, there was an enormous lot of hesitancy about adopting that type of testing, and a bit of uncertainty. If you move forward to work that our colleague Munir Pirmohamed in Liverpool has done with colleagues in Australia like Simon Mallal around HIV medicine, there was this discovery that a drug called abacavir, that if you carried a particular genetic change, that you had a much higher risk of having a really severe reaction to that. The adoption from the initial discovery to routine, worldwide testing happened within four years.   So, already we've seen a significant change in the appetite to move quickly to adopt this type of testing, and I see certainly within the NHS and within other health systems around the world, a real desire to adopt pharmacogenetics into routine clinical practice quickly and at scale, but also as part of a broader package of care, which doesn't just solely focus on genetics, but thinks about all the other parts that are important in how we respond to medication. So, making sure we're not on unusual combinations of drugs, or that we're taking our medicine at the right time and with food or not with food, and all of those other things that are really important. And if you link that to the pharmacogenetics, we're going to have a much safer, more effective medicines world.  Vivienne: I think one of the joys of working at Genomics England is that you see some of this work really going into clinical practice very fast indeed. And I should say actually that the Wolfson Centre for Personalised Medicine, the PPI group that Anita looks after so well, they've been very important in recruiting people to Yellow Card Biobank. And if anyone's listening to this, Matt, and wants to be part of this, how do they get involved? Or is it simply through the yellow card?  Matt: So at the moment, the Yellow Card Biobank is focusing on alopurinol.   Vivienne: So, that's a medicine you take for gout.  Matt: Which I use a lot in my rheumatology clinical practice. And direct acting oral anticoagulants, DOACs, which are used for vascular disease therapies and haemorrhage as a result of that. So, the contact details are available through the MHRA website, but I think more importantly, it's just that people be aware of the yellow card system itself, and that if they do experience adverse drug reactions, that they do actually complete a report form, ‘cos I think still actually a lot of adverse drug reactions go unreported.  Vivienne: I'm forgetting of course that we see Matt all the time in the Genomics England office and we don't think that he has any other home [laughter] than Genomics England, but of course he still sees some patients in rheumatology clinic. So, I want to now look to the future. I mean, I'm, as you both know, a huge enthusiast for pharmacogenomics, ‘cos it's the thing that actually, when you talk to patients or just the general public, they just get it straight away. They can't think why, if you knew about pharmacogenomics, why you wouldn't want to do it. But it's not necessarily an easy thing to do. How can we move in the future, Bill, to a more proactive approach for pharmacogenomics testing? Where would we start?  Bill: Yes, so I think we've built up really good confidence that pharmacogenetics is a good thing to be doing. Currently, we're doing that predominantly at the point when a patient needs a particular medicine. That's the time that you would think about doing a genetic test. And previously, that genetic test would only be relevant for that specific drug. I think we're moving to a place where, rather than just doing that one test that might be relevant to one drug, we'd be able to do a test which at the same price would generate information that could be relevant at further points in your life if you were requiring different types of medicine. So, that information would then be available in your hospital record, in your GP record, that you could have access to it yourself. And then I think ultimately what we would really love to get to a point is where everybody across the whole population just has that information to hand when it's required, so that they're not waiting for the results of a genetic test, it's immediately within their healthcare record. That's what we'd call pre-emptive pharmacogenetic testing, and I think that's the golden land that we want to reach.  Vivienne: So for instance, I might have it on my NHS app, and when I go to a doctor and they prescribe something, I show my app to the GP, or something pops up on the GP's screen, or maybe it's something that pops up on the pharmacist's screen.  Bill: I think that's right. I think that's what we're looking to get to that point. We know that colleagues in the Netherlands have made some great progress at developing pathways around that. There's a lot of public support for that. And pharmacists are very engaged in that. In the UK, the pharmacists, over the last few years, have really taken a very active role to really push forward this area of medicine, and this should be seen as something that is relevant to all people, and all health professionals should be engaged with it.  Vivienne: And on a scale of one to ten, how difficult is it going to be to implement in the NHS?  Bill: So, that's a difficult question. I think the first thing is identifying what the challenges are. So I have not given you a number, I've turned into a politician, not answered the question. So, I think what has happened over the last few years, and some of our work within the NHS Network of Excellence in pharmacogenetics and some of the other programmes of work that have been going on, is a really good, honest look at what it is we need to do to try to achieve pharmacogenetics implementation and routine use. I don't think the challenge is going to be predominantly in the laboratory. I think we've got phenomenal laboratories. I think we've got great people doing great genetic testing. I think the biggest challenges are going to be about how you present the data, and that data is accessible. And then ensuring that health professionals really feel that this is information that isn't getting in the way of their clinical practice, but really making a difference and enhancing it, and of benefit both to the healthcare system but more importantly to the patients.  Vivienne: Now, when I hear you both talk, my mind turns to drug discovery and research, and Matt, I'm quite sure that that's right at the top of your mind. Tell us how pharmacogenomics can help in drug discovery and research.  Matt: So, pharmacogenomics, I think actually just genetic profiling of diseases in itself just to start off with is actually a really good way of identifying new potential therapeutic targets, and also from derisking drug development programmes by highlighting likely adverse drug reactions of medications that are being considered for therapeutic trials, or targets that are being considered for therapeutic development. Pharmacogenomics beyond that is actually largely about – well, it enables drug development programmes by enabling you to target people who are more likely to respond, and avoid people who are more likely to have adverse drug reactions. And so that therapeutic index of the balance between likely efficacy versus likely toxicity, genetics can really play into that and enable medications to be used where otherwise they might have failed.  This is most apparent I think in the cancer world. A classic example there, for example, is the development of a class of medications called EGFR inhibitors, which were developed for lung cancer, and in the initial cancer trials, actually were demonstrated to be ineffective, until people trialled them in East Asia and found that they were effective, and that that turns out to be because the type of cancers that respond to them are those that have mutations in the EGFR gene, and that that's common in East Asians. We now know that, wherever you are in the world, whether you're East Asian or European or whatever, if you have a lung adenocarcinoma with an EGFR mutation, you're very likely to respond to these medications. And so that pharmacogenomic discovery basically rescued a class of medication which is now probably the most widely used medication for lung adenocarcinomas, so a huge beneficial effect. And that example is repeated across multiple different cancer types, cancer medication types, and I'm sure in other fields we'll see that with expansive new medications coming in for molecularly targeted therapies in particular.  Vivienne: So, smaller and more effective trials rather than larger trials that perhaps seem not to work but actually haven't been tailored enough to the patients that are most likely to benefit.  Matt: Yeah, well, particularly now that drug development programmes tend to be very targeted at specific genetic targets, pharmacogenetics is much more likely to play a role in identifying patients who are going to respond to those medications. So, I think many people in the drug development world would like to see that, for any significant drug development programme, there's a proper associated pharmacogenomic programme to come up with molecular markers predicting a response.  Vivienne: We're going to wrap up there. Thank you so much to our guests, Bill Newman, Anita Hanson, Matt Brown, and our patient Jane Burns. Thank you so much for joining us today to discuss pharmacogenomics in personalised medicine, and the benefits, the challenges and the future prospects for integrating pharmacogenomics into healthcare systems. And if you'd like to hear more podcasts like this, please subscribe to Behind the Genes. It's on your favourite podcast app. Thank you so much for listening. I've been your host, Vivienne Parry. This podcast was edited by Bill Griffin at Ventoux Digital and produced by the wonderful Naimah. Bye for now. 

This episode is with Dr. Grant Lipman, founder of GOES Health, a wilderness medicine resource designed to democratize outdoor health through an app. Dr. Lipman is fascinated by how humans adapt and perform in extreme environments, including athletes at altitude. He also enjoys trail running with his dog, climbing mountains and skiing.  Topic timestamps: 3:20 Introduction to Dr. Grant Lipman and this episode 8:40 Altitude: the effects on the body and performance; acclimatization and training 20:35 Heat/ cooling: hydration; performing in hot conditions; cooling strategies 31:10 Anti Inflammatories: potential risks; pain management during races  35:20 Blisters: prevention and treatment with paper tape 39:40 GOES app: an outdoor medicine resource; GOES founding story 51:50 What did we miss? Sodium supplementation; ice baths, sauna and heat Check out GOES and reach Dr. Lipman at drgrant@goes.health  Here are the links to the studies Dr. Lipman referenced: Ibuprofen prevents altitude illness  High altitude sleep tents Acetazolamide on sleep Chemical cold packs for cooling Acute kidney injury in ultramarathon runners Ibuprofen effect on AKI in ultramarathons  Blister treatment Factors contributing to successful ultramarathons Paper tape for blister prevention Chemical cold packs for cooling Sodium supplements and performance in ultramarathons Large volume hypertonic saline for exercise-associated hyponatremia Follow GOES on Instagram @goeshealth and For The Long Run @forthelrpod  If you want to join us for exclusive deals, giveaways, and community connection with other listeners of the show, head to the link in the show notes to join our brand new community, The Group Run. No paywall, just sign up to be part of our community and have the chance to win cool stuff and connect with me and other audience members! https://app.dropstation.io/forthelongrun --- Support this podcast: https://anchor.fm/forthelongrun/support  Past guests on For The Long Run include: 177. Molly Seidel; 226. Mike "Kofuzi"; 228. Kara Goucher; 59. Shalane Flanagan; 234. Camille Herron; 198. Courtney Frerichs; 229. Jes Woods; 207. Tyler Andrews; 197. Dean Karnazes; 206. Katie Arnold; 220. CJ Albertson; 153. Joe Holder; 199. Kelly Roberts; 188. Gwen Jorgensen; 205. Emily Abbate; 209. Sara Vaughn; 174. Nick Bare; 97 Amelia Boone; 101. Courtney Dauwalter, 219. Dylan Bowman; 191. Matt Chittim; 200. David Roche; and more! PUMA This episode of the For The Long Run Podcast is sponsored by PUMA.  I've been running in the Deviate Nitro First Mile and I love how it has a focus on sustainability, made from at least 20% recycled material. Check out a pair for yourself at PUMA.com and use the code FTLR24 for 20% off any PUMA run or train products. Boulderthon Boulderthon is Colorado's premier fall event and was just rated top 10 in America by USA Today. This annual sell-out race is one of the fastest-growing in the country, and features a 5K, 10K, Half, Full and even a Kids Run. Use code FTLR20 for $20 off Half or Full to reserve your sport and save! Register today at www.boulderthon.org. Tifosi With an anti-bounce fit, shatterproof and scratch resistant lenses, and rubber pads on the nose so that sweat doesn't get in the way of being able to see, Tifosi sunglasses are made with activity in mind. Use code FTLR for 15% off a pair through this link. I suggest the Swank or Tsali models. --- Support this podcast: https://podcasters.spotify.com/pod/show/forthelongrun/support

Dr. Maire Finn, GP in Clare

In this special reflections episode, I, take you through my journey over the past six months and share my plans for the rest of 2024. Celebrating nine years of the Tough Girl Podcast, I'm recording from my bedroom on the Wirral, UK, offering a personal insight into my life. I'll recount my adventures, starting the year in Wellington, New Zealand, and returning to the UK in March. You'll hear about the highs and lows of walking the Camino via De La Plata, dealing with physical and emotional challenges, and my personal health journey, including gut health improvements and medical support. I'll also discuss the financial challenges of maintaining the podcast, the support from my Patreon community, and my strategies for growth on Instagram and YouTube. With nearly 3.5 million downloads, I'm focused on reaching over 1,000 episodes and continuously improving my craft. Looking ahead, I'll talk about walking the South West Coast Path, participating in the Armchair Adventure Festival, Tremula Festival in Brighton and continuing my health and fitness regimen. As I prepare for new podcast episodes in September, I'll express my gratitude to you, my listeners and supporters. Join me for an honest, inspiring, and motivational episode as I reflect on my journey this year and share my future aspirations. Thank you for being part of the Tough Girl Podcast community and for your unwavering support. ***  Don't miss out on the latest episodes of the Tough Girl Podcast, released every Tuesday at 7am UK time! Be sure to hit the subscribe button to stay updated on the incredible journeys and stories of strong women.    By supporting the Tough Girl Podcast on Patreon, you can make a difference in increasing the representation of female role models in the media, particularly in the world of adventure and physical challenges. Your contribution helps empower and inspire others. Visit www.patreon.com/toughgirlpodcast to be a part of this important movement.  Thank you for your invaluable support! *** Show notes Intro 9 year Anniversary of the Tough Girl Podcast Based on the Wirral, UK Recording from my bedroom Snake Plant benefits Recording from my bed Find out more info about me Quitting my job in 2013 Travelling for 2 years Starting Tough Girl Challenges Taking on challenges from the Marathon des Sables, to hiking the Appalachian Trail in 100 days My mission to increase the amount of female role models in the media especially in relation to adventure and physical challenges Sharing my adventures  Sharing my stories on other podcasts Ask me a question via Instagram Sharing to be more transparent Why I'm not complaining Recording at the end of July Where have the past 6 months gone? Starting the year in Wellington, New Zealand Listen to the New Zealand episodes Back to the UK in March  Camino V New Zealand  YouTube shorts and why it didn't work for me Total stats and tracking my walks (distances, accommodation, costs etc) Getting stung by bag charges The challenges on the Camino Emotional wobble Dealing with negative thoughts Blisters, and feet issues  Nutrition and food and the challenges and consequences Not feeling good Am I tired or just being lazy Starting to note appreciate what I was doing What am I doing? Am I enjoying this? Do I need to take a step back and do something different? Having plans change and cancelled Cotswold Way with Gemma Not being able to make any more decisions  Watch the Cotswold Way Vlogs on Youtube Getting a Drs appointment and having a blood test done Blood test results Going to AIM - Hoylake  Using the rebalance bed for sleep Seeing Doctors, and naturopath All the tests being done. Vitamin I Needing to improve my gut health  July…. Needing to make money Patreon numbers declining  Off to Work  Starting to feel better and having more energy Armchair Adventure Festival  Running an Adventure Planning Workshop Live podcast episodes from the festival coming out in the late September  Walking the South West Coast Path (SWCP) - UK National Trail (630 miles) Making my way to Minehead  Working with ZOLEO #ChallengewithZOLEO  Not having a hard deadline Tremula Festival 20th September, Brighton  Francesca Turauskis - Advocate for Adventure & Epilepsy, walked the Camino de Santiago solo. May 21st 2019.   Catching up with friends September and planning to be home for October, November and December Needing to stop and take a moment.  Trying to do to much  Trying to figure out how I can fit everything in Mobility training with Franco  Strength training Run club?  Editing the vlogs for New Zealand and SWCP Health, fitness, vitality, strength  New Tough Girl Podcasts interviewing happening in September   Podcast numbers  Coming up to 3.5 million downloads  Patreon - regular source of income which helps to fund the running costs of the podcast  Focusing on what I can control  How can I add value? How can I get better? Being able to talk to people  Goal to get over 1000 episodes  Instagram - 13.1k followers Facebook - over 5k Youtube growth….  Editing and the creative process  The next reflections episode to happen at the end of the year  Thank you for listening and for your support    Social Media Website: www.toughgirlchallenges.com Instagram: @toughgirlchallenges Facebook: Sarah Williams   

Come to a Dehoarding Accountability Zoom Session: http://www.overcomecompulsivehoarding.co.uk/ticket Subscribe to the podcast: https://www.overcomecompulsivehoarding.co.uk/subscribe Podcast show notes, links and transcript: http://www.overcomecompulsivehoarding.co.uk/  Incredible conversation with the ever-insightful KC Davis of Struggle Care. From discussing the impact of accumulating unused items to exploring the mental and emotional barriers people face in decluttering and tidying up, this episode covers a wide range of strategies and insights to help you on your dehoarding journey. We look at the shame and stigma associated with struggling with care tasks, including dehoarding, and the impact on individuals' self-worth and ability to seek help, and replace the shame with an approach rooted in self-compassion and moral neutrality towards care tasks. So if you're looking for practical tips, empathy, and support on your dehoarding journey, you won't want to miss this episode! Understanding Care Tasks and Struggles Definition of "care tasks" Stigma and shame surrounding struggles with care tasks Impact on self-worth and ability to seek help Overcoming Shame and Stigma Fear and self-criticism Importance of self-compassion and supportive community Motivation and the limitations of shame Individualised solutions rooted in self-compassion Thriftiness and environmental concerns Strategies for Task Initiation and Motivation Challenges for hoarders and those with ADHD Differentiating motivation and task initiation Small steps, transitions, and tools for task initiation Starting the Decluttering Process No one right way to start Making small decisions and using timers Involving friends in parting with items Overcoming Emotional Barriers to Decluttering Impact of accumulated items and their eventual outcome "5 things theory" to overcome resistance Adjusting the tidying process and taking small steps consistently Strategies for Organising and Tidying Up Breaking tasks into smaller steps Visual storage ideas and creating rituals Setting priorities and challenging societal norms Judgments based on work, race, and appearance Many people feel therapy isn't addressing their needs. Shame doesn't lead to lasting behaviour change. Self-help methods are not one-size-fits-all. Permission to accommodate leads to lasting change. Challenges of ADHD and executive functioning explained. Declutter by what I need, love, keep. Motivation leads to easier hard work and decluttering. Take small steps and make decisions. Break tasks into small steps. Community support for navigating vulnerability. Many people find online content more helpful than traditional therapy, reflecting societal attitudes towards seeking help. Shame and social pressure don't guarantee change. Self-help space lacks personalised solutions for diverse challenges. Universal methods don't address individual barriers and needs. People give themselves permission to accommodate and it leads to curiosity, not necessarily a finish line. Challenges with executive functioning and organisation due to ADHD, struggling with clutter and distractions. Sort items by frequency of use, happiness, and necessity. Prioritise what to keep, rather than what to discard. Motivation leads to easier wins, declutter by discussing meaningful items with friends. Taking small steps without pressure, performing tasks with enjoyable activities. Breaking tasks into smaller steps and utilising a simple action to initiate it.

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Lauren: Hi there! I have had a cold for almost 2 months now. I'm a breastfeeding mom 4 months postpartum. So I know I can't take a lot of things and my sleep recovery isn't the best. I thought I was over it but still had mucus congestion. Constantly blowing my nose & the mucus would be bright yellow. I've been taking a lot of immunity supplements, teas, and doing sauna every so often. Just yesterday I randomly started loosing my voice and now have a very sore throat. Any advice? Thanks!   Kristen: Dr. Cabral, A few months ago I had a fever blister break out on the left side of my face. Even now after the blister has fully healed, I can still feel tingling on the left side of my face, near my left ear, similar to when an outbreak is about to occur but no new blister has emerged. I also currently have a cold and only the left side of my face feels “sick” - only my left ear hurts, only the left side of my throat hurts. I also have been dealing with double vision issues for years, and a recent CT scan showed inflammation of the muscles in my left eye. Could all of this be related to the virus that causes fever blisters since it's all only on the one side of my face that I had the blister? If it is viral, how can I get rid of the virus for good? I am willing to try anything!   Kelly: Hi Dr. Cabral- thank you so much for your open source naturopathy podcast! I have lipedema, and while research on the condition is slim, it is being suggested that women with lipedema can try taking 600-1200mg guaifenisin (more commonly known as Mucinex) two times per day because it apparaently helps to break down of the adipose tissue associated with lipedema, which is otherwise diet and exercise resistent. I take no other medications, but I started taking 600mg twice per day because the double dose made me dizzy. I am wary of taking a pharmaceutical drug that has side effects including kidney stones. Can you provide any information on the mechanism in which a mucus thinning medication would break down stubborn fat?   Shelly: Helllo. Wanted to ask about deficiencies in sex hormones and poor gut health. I lost my period when put on birth control (BC) at age 17 and it doesn't come back unless on BC but I stopped BC over 6 years ago. My estrogen and progesterone has been super low and I have had lots of stomach issues like bloating and constipation along with weight gain. Every time I seem to resolve my gut it always comes back. No one has told me that I need to fix my hormones first. I'm now on BHRT and feel better with more energy and hoping with balanced hormones my gut will start to repair itself.   Emma: Hello Dr. Cabral, thank you for being my #1 reference with all things holistic & natural health. I listen every day & was able to uncover underlying health dis-eases stemming from your teachings on this podcast! :) What are your thoughts on meridian testing? What about German New Medicine? Do you believe either have validity ? I've been working with a consultant for 2 months but don't feel a difference yet. Thank you in advance.     Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3053 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

In this special bonus episode, Doc debates Carl Mandrioli, host of the Backpacking and Blisters podcast, on what is the world's toughest race. Doc advocates and defends the Barkley Marathons, and Carl does the same for the Eco Challenge. Stuntwoman and TV host Alice Ford weighs into the fray as the guest moderator and judge. Settle in and buckle up as Doc and Carl dust off their high school debating skills and duke it out, and Alice does her best to filter through the heated rhetoric and come up with a winner. Epic. Learn more about your ad choices. Visit megaphone.fm/adchoices

Scotty talks to author, editor, and publisher Aric Sundquist about growing up a "Yooper" in Michigan's Upper Peninsula, and how his mother's love of Stephen King and Dean Koontz, sparked his early interest in dark fiction. Aric discusses the influence of Koontz, King (especially his 1978 collection "Night Shift" and the subsequent 1985 anthology film adaptation "Cat's Eye"), Lovecraft, and fantasy writers like Tolkien, Jordan, and Tad Williams on his work, and how Aric's rediscovery of Ray Bradbury's more macabre tales as an MFA candidate in Creative Writing informed his decision to move specifically into writing horror. Aric also talks about the lessons he learned in his creative writing program, and how he applies them to his work as an editor and publisher at Dark Peninsula Press, the independent publishing company he founded in 2019. He and Scotty talk about the anthologies Dark Peninsula Press has produced (spoiler alert: Scotty's stories have appeared in just about all of them), and Aric outlines his vision for the company's future. And, of course, they talk about Aric's own writing, from his absurdist comic take on cosmic horror with his novella "Serious Applicants Only" (2021, Dark Peninsula Press) to his terrifying, Joyce Carol Oates-inspired short story "The Run" (2014, "Night Terrors III"). You can find Aric online at https://aricsundquist.weebly.com You can find Dark Peninsula Press online at https://www.darkpeninsulapress.com You can read Aric's story "The Way We Are Lifted" in the anthology "Fearful Fathoms, Vol. 1: Tales of Aquatic Terror" (2017, Scarlet Galleon Publications): https://www.amazon.com/Fearful-Fathoms-Collected-Aquatic-Terror/dp/1974213021/ You can read Aric's story "Rise of the Corpse Eaters" in the anthology "More Bizarro Than Bizarro" (2017, Bizarro Pulp Press): https://www.amazon.com/More-Bizarro-than-Leza-Cantoral/dp/1947654039/ You can read Aric's story "Conditioned Apocalypse" in the anthology "Year's Best Body Horror 2017" (2017, Gehenna & Hinnom): https://www.amazon.com/Years-Best-Body-Horror-Anthology/dp/0997280344/ You can read Aric's story "The Run" in the anthology "Night Terrors III" (2014, Blood Bound Books): https://www.amazon.com/Night-Terrors-III-Horror-Anthology/dp/1940250145/ You can read Aric's story "The End of Autumn" in "Evil Jester Digest, Vol. 1" (2012): https://www.amazon.com/Evil-Jester-Digest-Volume-One/dp/0615613241/ You can read Aric's story "Butcher's Block" in "If I Die Before I Wake #7: Tales of Savagery & Slaughter" (2022, Sinister Smile Press, also featuring Scotty's story "Monkey Cage"): https://www.amazon.com/If-Die-Before-Wake-Slaughter/dp/1953112323/ All Dark Peninsula Press anthologies can be found on Amazon, or at: https://www.darkpeninsulapress.com/store.html These include: • "Negative Space: An Anthology of Survival Horror" (2020, featuring Scotty's story "Luminescence") • "Violent Vixens: An Homage to Grindhouse Horror" (2021, featuring Scotty's story "The Whole Price of Blood") • "Negative Space 2: A Return to Survival Horror" (2023, featuring Scotty's story "Brown Bear, Brown Bear") • "The Cellar Door, Issue 1: Woodland Terrors" (2022, featuring Scotty's story "Blisters") • "The Cellar Door, Issue 2: Forbidden Magic" (2023, featuring Scotty's story "My Church is Black") • "The Cellar Door, Issue 3: Dark Highways" (2023, featuring Scotty's story "Twelve Miles. Two Hours.") Be sure to put the next episode of Daniel Braum's "Night Time Logic" into your calendar! Daniel is the author of "The Night Marchers and Other Strange Tales" and "The Serpent's Shadow" (Cemetary Dance). His YouTube series "Night Time Logic" focuses on the strange, weird, and wonderful side of dark fiction through readings and discussions with diverse authors from around the world. You can tune in on Daniel's YouTube Channel, https://www.youtube.com/@danielbraum7838 Daniel's next episode will be LIVE on August 29 at 7 p.m. EST, and will feature author Paul Tremblay. Follow the event on Facebook at https://www.facebook.com/events/797113355174358 This podcast is powered by Pinecast.

Resource Rowing Blisters And Skin Injuries ebook https://fastermastersrowing.com/wp-content/uploads/2024/05/2022-Rowing-Blisters-And-Skin-Injuries-Prevention-Cure-And-Management.pdf 3 Value Bombs 1) wearing gloves is a good way to prevent rowing blisters. 2) cover band aids and plasters with electrical tape when rowing 3) applying band aids 40 minutes before you go rowing makes it stick better to your skin. Timestamps 01:00 Prevent rowing blisters Hand cream may be insufficient to keep your hands soft and supple enough to prevent blisters forming. By wearing rowing gloves - padded palm and finger protection. The Crew Stop gloves are specialist - light and flexible gloves. 04:00 Treating rowing blisters 1 - your blister is filled with fluid. Tape your hands. But band aids and plasters are not good when you row - they roll up and stick to the oar handle. 2 - raw skin exposed. 3 - skin around the edges is inflamed. 4 - raw skin is cracked. Bind the edges of the crack together with tensioned band aids. A butterfly cut made with micropore plaster. 5 - Trim the hard old skin around the blister wound 6 - Healed blister but a raised callous on your hand. Don't allow blisters to form under the callous - they hurt because they're deep in your epidermis. rec.sport.rowing discussions about blisters https://groups.google.com/g/rec.sport.rowing/search?q=blister Methylated spirits are NOT a good solution - avoid at all costs as it kills living skin tissue. 13:00 Good hand hygiene when rowing Want easy live streams like this? Instant broadcasts to Facebook, YouTube, LinkedIn. Faster Masters uses StreamYard: https://streamyard.com/pal/d/5694205242376192

Welcome to episode 195 of the Women's Running podcast. I'm your host Esther Newman and she's your other host Holly Taylor. On this podcast we talk about health, politics, stuff on TV and what we ate last night. Occasionally, we talk about running. Running recoveryThis includes our second chat with Jordan from Coopah, who talks to us at around the 25 minute mark about recovery - we're talking about sleeping, eating and drinking water, and doing all those things in the right amounts at the right time. We also chat about how to cope when you've got races that are close together – listen to her advice here: you can't race every single one. BlistersBefore and after that, me and Hol are chatting about how we're getting back into running post-New York, which leads on to some gruesome blister and foot chat. We also talk about sports massages and our varying experiences of. It's a VERY silly episode – let us know if you think we should always record at 3pm on a Tuesday, or in fact should never do that again, because it descends into madness. Join us!Now, do please come and join us on Patreon – you can get a ton of extra Pod Squad benefits from just £2 a month, including newsletters, Live chats, and you can join our exclusive and very lovely Discord community filled with wonderful runners just like you. All of that and you'll always be the first to know about trips like New York! Go to patreon.com/womensrunning to find out more. Lovely extra bits• Jordan was giving us the sort of advice you can get your mitts on when you sign up to the Coopah run coaching app Subscribe to Women's Running – join us today to save loads, it's only £3.50 an issue!Get your hands on How to Run 5K with Esther and Holly, available at shop.womensrunning.co.uk / Extras·      Download a FREE mini mag to help you run 5K! Go to womensrunning.co.uk/runBuy a Pod Squad t-shirt!Do join us on Patreon so you can come and chat in our new Pod Squad community on Discord! Go to patreon.co.uk/womensrunningEmail us at wrpodcast@anthem.co.uk with any questions or running stories  Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

This week, Dane is convinced that Nasuada is trying to kill the Stronghammer, while Jax goes down a rabbit hole on Alagaesian television. This episode covers Chapters 11-17 of Inheritance, the third book in the Inheritance Cycle by Christopher Paolini.   How to support us:  Get some of our merch  Support us on Patreon    Where to find us:  Website: isthisjustfantasypod.com TikTok: @isthisjustfantasypod Instagram: @justfantasypod   Contact us:  You can contact us directly at: isthisjustfantasypod@gmail.com   Credits:  Our music was written and performed by Adam Blotner Cover artwork by Neil Kohney Every episode was mixed, shot, and edited by Kevin Davis at the Guerrilla Media Company   Learn more about Christopher Paolini and buy Eragon so you can read along! 

In today's episode of 'Between Us Moms,' Hallie reveals why she's feeling so emotional about 'Toy Story' these days while also preparing for baby number 2 -- Katie details a recent pediatrician visit that broke her mama heart as she shares Kaia's first real scary incident. The ladies also share their thoughts on Kristin Cavallari's recent revelation that she is open to having kids with her 24-year-old Tik Tok star boyfriend -- and explain why they are upset with Shakira's take on 'Barbie.' The OMG of the week is a big one -- with one mama detailing her experience of why she returned to work 10 days after having a c-section! Whew! And we show love to two mama BFFs of the week -- Toni Wells and Beth Thomas. New episodes of Between Us Moms air Tuesdays and Fridays. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Support our sponsors this week by using the links below for the exclusive Solomonster offers!EXPRESSVPN - Get an extra three months FREE of the #1 trusted VPN at http://www.expressvpn.com/solomonsterFACTOR MEALS - Use the code SOLOMONSTER50 at https://factormeals.com/solomonster50 to get 50 PERCENT off!Solomonster reviews WWE Monday Night Raw for March 18th with Cody Rhodes finally going in hard on The Rock, Becky Lynch and Nia Jax take some hellacious bumps in their Last Woman Standing match, Sami Zayn and GUNTHER make it official for Wrestlemania, plus three tag team qualifying matches for the ladder match at Mania.***Follow Solomonster on Twitter for news and opinion:http://www.twitter.com/solomonsterSubscribe to the Solomonster Sounds Off on YouTube:https://www.youtube.com/user/TheSolomonster?sub_confirmation=1Become a Solomonster Sounds Off Channel Member:https://www.youtube.com/channel/UC9jcg7mk93fGNqWPMfl_Aig/join

Trying to pick out new running shoes? Listen to this episode before you do!Timestamps of big takeawaysNeutral vs. Stability vs. Motion Control Shoes[01:12] Coach Valerie discusses the different types of running shoes and emphasizes that comfort is the most important factor.[02:21] She explains the idea behind motion control and stability shoes, and why they may not be the best choice for runners.[04:17] Coach Valerie talks about the problems with gait analysis and how shoes shouldn't control foot movement.Proper Running Technique[05:16] Having a loose and free ankle while running is critical. The foot should land neutrally on the ground.[07:33] The focus should be on the correct movement of pulling the foot, rather than foot strike and impact.Minimalist vs. Cushioned Shoes[08:25] There should be a balance between having enough cushion for comfort and protection, but not so much that it disconnects the runner from the ground.[09:03] We recommend trying to go as minimalist as your foot will allow.Trail Running vs. Road Running[10:15] Running is running, regardless of the surface, but Coach Valerie acknowledges that trail running may require shoes with more protection, such as a rock plate.Proper Shoe Fit[13:08] Being able to move and wiggle the toes inside the shoe is important. You don't want to feel constricted.[13:37] Coach Valerie emphasizes the importance of trying on shoes, with or without socks, to ensure a proper fit and comfort. If possible, walk around in the store to make sure they feel right.[14:17] One reason the shoe needs to fit well is to avoid sliding around, which can cause blisters.Blisters and Running Technique[15:03] Blisters often come from chafing and can be a sign that the runner's foot is moving forward or back too much, indicating a need to focus on pulling. However, other causes of blisters can be weird stitching in the shoe or wet and bunched-up socks.[15:36] Blisters during downhill or trail running can be caused by the foot coming out in front and sliding in the shoe.Wet Conditions and Shoe Integrity[16:40] Wet shoes or socks can lose their integrity and cause sliding - again, this can lead to blisters.Rate, Review & Subscribe ReminderDon't forget to like and subscribe to our show. You can also rate and review our show on Apple Podcasts! We're on Spotify as well!Links to check out-- https://www.runrx.fit/-- FREE 30 day reboot on YouTube by RunRX https://www.youtube.com/playlist?list=PLDPcF8ZrDdILC8bYyn2zR-4xvqKRzp2re-- Follow us on Facebook https://www.facebook.com/runrxfit/ and Instagram https://www.instagram.com/runrx/ -- Have questions? Email us at support@runrx.fit-- Subscribe to Our YouTube Channel: https://www.youtube.com/@RunRX

WWR 11 ☉ Playing Blister Critters w. Jenn de la Vega & Anthony Grasso!Join Wythe, Chris, and very special guests Jenn de la Vega (Fun City Ventures, Replay) and Tony Grasso (creator of Blister Critters) as they delve into the cartoonishly hilarious TTRPG, Blister Critters, now on Kickstarter!In this innovative and surreal game, you play as a small animal who can wield bizarre mutations called Blisters as well as physics-bending Nonsense powers. These strange abilities—artfully developed within the Grit System—will help you survive in a vast, cruel suburbia populated by fellow Critters and their feral counterparts, Beasts.To learn more about Blister Critters, and to back it on Kickstarter, visit play.blistercritters.comTo learn more about the wonderful Jenn de la Vega, check out randwich.esTo learn more about Stillfleet Studios, take your local stillworks to Stillfleet.comAnd to learn more about Danse Macabre, simply venture to timespace.place

Tim, Hannah Claire, Libby Emmons, & Serge join Dom Lucre to discuss Democrats panicking about 2024 election as they lie about blisters on Trump's hands, Texas' National Guard arresting illegal immigrants who cross the border, Democrats losing support among young voters, and Sean Strickland going viral again for saying hate speech is not real. Learn more about your ad choices. Visit megaphone.fm/adchoices

Features vintage recordings by Boyd Raeburn, Will Bradley, The King Sisters and many more.  We also learn how to treat those annoying Cold Sores and Fever Blisters. Consider supporting The Big Band and Swing Podcast by becoming a Hepcat.  Learn more at SupportSwing.com. * All music in this podcast are Creative Commons.  Artists are credited within the podcast.

The MidPacker Pod is part of the Freetrail network of Podcasts. You can now support the MidPacker Pod on ⁠Patreon⁠. Make sure you leave us a rating and review wherever you get your pods. Want to leave Troy some feedback, recommend a guest, or make a suggestion? ⁠LINK HERE⁠ In this episode of the pod, Troy Meadows talks with Yan Fournier.  Yan is a father, trail runner, and ultra runner who does Buis Dev for SACO. A company that produces the LED technology used at the Sphere in Las Vegas. Yan and Troy met through the Freetrail community and have become good friends over the digital landscape. This year at Grindstone they got the chance to meet in person and share quite a few miles on the course. Yan Fournier shares his journey from overcoming back problems to discovering trail running and finding balance in his life. He discusses the intersection of his work in business development with his passion for trail running. Yan also talks about running with his sons and the joy of sharing the trail with them. He shares his experiences at races like Quebec Megatrail and Grindstone 100. In this part of the conversation, Yan and Troy discuss aid stations and crew support, dealing with foot problems during races, the impact of wet conditions on blisters, Yan's expedition in the Atacama Desert, and the importance of dreaming big and being consistent. In this conversation, Yan discusses his personal journal on Instagram and his involvement with Kapic 1. He emphasizes the transparency and authenticity of his Instagram account, where he shares the ups and downs of his life. Yan also highlights the Kapic 1 expeditions and coffee, encouraging others to participate and support the cause. Chapters 02:11 Overcoming Back Problems and Discovering Trail Running 07:32 Finding Balance with Trail Running and Family 11:13 Running with Sons and Staying Young 14:36 The Intersection of Work and Trail Running 19:13 The Benefits of Running for Mental Clarity 27:01 The Work of Seco and Projects Managed 30:21 Running Quebec Megatrail 37:17 Running with Troy at Grindstone 100 40:54 Aid Stations and Crew Support 45:35 Blisters in Wet Conditions 52:59 Yan's Expedition in the Atacama Desert 56:54 Impossible to Possible and Kapic 1 Coffee 01:00:27 Future Race Plans 01:12:04 The Importance of Dreaming Big and Being Consistent 01:20:18 Kapic 1 Expedition and Coffee Yan's Personal Links IG - ⁠@trail.yan⁠ Things we talked about on the pod ⁠Saco LED technology⁠ ⁠Sphere In Vegas⁠ ⁠Gorge 50k⁠ ⁠Snowdonia 100k⁠ ⁠Quebec Mega Trail 100 miler⁠ ⁠Grindstone 100 miler⁠ ⁠UTMB⁠ ⁠Ray Zahab⁠ ⁠Kapik 1 Dessert Expedition ⁠ ⁠Impossible to Possible⁠ ⁠Kapik 1 Coffee⁠ ⁠Howe Stern⁠ - Race Photographer If you are enjoying the content, please consider supporting our sponsors using the links below. Sponsor Links:  ⁠Run Trail Life⁠ - This is a brand I am super passionate about because I am the Founder and Chief everything officer for RTL. Run Trail Life Brings you casual apparel that lets you show off your love of trail running and ultrarunning while giving back to ensure that everyone has access to the beauty of nature for generations to come. With each item purchased, we donate $1 to runners for public lands. Use code: midpackerpod to double the donation from your purchase.  Visit RunTrailLife.com to check out our line of Hats and Organic cotton T's. ⁠Freetrail⁠ - Bring Trail Culture with you everywhere you go and join an amazing community of extraordinary trail runners. Freetrail Pro membership is just $96 a year, giving you access to the Freetrail Slack community, training plans, weekly office hours, and so much more. I absolutely love this community and have personally used the training plans to get ready for my ultra efforts. Visit Freetrail.com to sign up today. MidPacker Pod Links: ⁠Instagram⁠ | ⁠Patreon⁠ Troy Meadows Links: ⁠Instagram⁠ | ⁠Twitter⁠ | ⁠Website⁠ | ⁠Strava⁠ Freetrail Links:⁠ Freetrail Pro⁠ | ⁠Patreon⁠ | ⁠Instagram⁠ | ⁠Website⁠ | ⁠YouTube

Scrump and Drew talk about the music of Lil Wayne, Nelly Furtado, The Doors, Method Man, Nas, T. Rex, Wilco, Tony Basil, Hall & Oates, and more! Maneater by Hall & Oates Hey Mickey by Toni Basil A Milli by Lil Wayne Maneater by Nelly Furtado Not to Touch the Earth by The Doors In The End by Method Man and Das ft Coast Contra 20th Century Boy by T. Rex Just a Kid(with the Blisters) by Wilco   Patreon Merchandise   Sponsors: Manscaped Use promo code: PWTCAST to get 20% off AND Free shipping   Social Media: Twitter Instagram 

Join Alex and Jordyn as they explore the ups and downs of being single during the holidays. They tackle topics with wit and honesty, from the importance of size in relationships to choosing the right engagement ring. The duo also shares amusing anecdotes about family quirks, like sleeping in the same room as grandma, and delves into what men really think about female body parts. This episode is a blend of laughter, candor, and real-talk, perfect for anyone navigating the single life or just seeking a fun listen! Follow us on instagram at @meangirlpod, Alex @justalexbennett and Jordyn @jordynwoodruff. Visit our website for more! https://www.justmediahouse.com/podcasts/ Thank you to our partners this week: OUAI: Go to https://theouai.com/ for 15% off site wide when you enter promo code GIRL. RITUAL: Visit https://ritual.com/%20MEANGIRL to start Ritual or add Essential For Women 18+ to your subscription today. INCOGNI: Go to https://incogni.com/MEANGIRL?utm_campaign=youtube&utm_source=Blue_Partner&utm_medium=meangirl and use code meangirl to get an exclusive offer of 60% off. Timestamps: 00:00:00 - Shoe Tying and Fashion Choices 00:01:39 - Talking about Blisters and Healing 00:03:14 - Thanksgiving with Family 00:05:06 - Emotional Healing and Thanksgiving Bonding 00:06:54 - Supporting Loved Ones Through Divorce 00:08:33 - Wine Nights and Majan Lessons 00:10:12 - Watching "Desperate Housewives" and Holiday Gift Ideas 00:12:02 - Sleeping in a Twin Bed at Grandma's House 00:13:54 - Sleeping in the same room with Grandma 00:16:03 - Unconventional Thanksgiving Conversations 00:18:00 - The Perception of Vaginas 00:19:53 - The Male Perspective on Vaginal Appearance 00:21:50 - Discussing Vaginal Aesthetics and Terminology 00:23:36 - The Importance of Trusting Multivitamins 00:25:19 - Men's Conversations about Women's Bodies 00:27:02 - Different Styles and Locker Room Etiquette 00:28:37 - The Fascinating Concept of "Grower" and "Shower" 00:30:14 - Arousal Control During Massages 00:32:00 - Putting Him Down or Not 00:33:46 - Protect Your Personal Data 00:35:36 - The Expensive Wedding Dilemma 00:37:22 - The Value of a Wedding 00:39:12 - Intimate Wedding on the Beach 00:40:56 - Bridesmaid dress shopping 00:42:47 - The Importance of Ring Preference 00:44:33 - Princess cup preferences 00:46:15 - Size and Height Correlation 00:48:11 - Balancing Celebrations with Two Families 00:49:55 - Spending Quality Time with Family 00:51:27 - Making Time for Family 00:53:05 - Listener Questions and Relationship Problems Produced by: Creative Evolution Studios https://www.creativeevolutionstudios.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Steelers Lose... Did they take the Cardinals to lightly? Did everything just go wrong? Do they people in the Facebook comments have the answers - Thank you to everyone who came out or donated online and helped us Stuff A Bus last week - We check in to see what happened over the weekend on the PGH Scanner account - Have anything fun for the show or just want to say hi.... Listen on iHeartRadio click the little mic and leave us a talkback message

Doc joins Carl and Derek on the Backpacking and Blisters podcast to share some incredible guests, stories, and moments from Hiker Trash Radio. Tune in and learn something new about Doc and HTR! Learn more about your ad choices. Visit megaphone.fm/adchoices

Show Notes: https://wetflyswing.com/529 Presented By: Smitty's Fly Box, Togens Fly Shop, Jackson Hole Fly Company, Dette Flies Sponsors: https://wetflyswing.com/sponsors Join us for an engaging episode as we kick things off with the tale of how Carl was bitten by the backpacking bug and how it eventually led to them starting a podcast. His journey began with a burning desire to be part of the adventures his high school friends embarked on, and he has never looked back since. Their podcast, Backpacking and Blisters came to life from the back of a minivan during a return trip from Glacier National Park. Their goal was to create something entertaining, something more than what was already out there, and it's safe to say they've achieved that and much more. Listen in as we share invaluable tips on gear selection and trip planning for backpacking adventures. From discussing Carl's love for trail running to exploring the various gear options for backpacking, we leave no stone unturned. Get ready for some exciting stories including a nail-biting encounter with a grizzly bear! Further, we talk about how to select the right balance between comfort and durability when choosing your gear and the importance of researching different brands. We wrap up the episode with a thoughtful discussion on handling podcast guests and the importance of being a responsible and respectful host. We share insights into how to evaluate the authenticity of a guest, their expertise, and how to handle tricky questions. This episode is a treasure trove of information, filled with myths, tips, and advice on everything backpacking. Whether you're a seasoned hiker or a newbie looking to venture into the great outdoors, this episode is sure to equip you with the knowledge and inspiration you need. Episode Chapters - Backpacking and Blisters (0:00:05) - Podcast Origins and Guest Selection Carl and Derek started a podcast to entertain, meeting many in the outdoor community after a backpacking trip to Glacier National Park. (0:10:47) - Gear and Trip Planning Tips Carl discusses ultra-light backpacking, how much weight children can carry, and his passion for trail running and backpacking trips. (0:21:23) - Choosing Gear for Outdoor Activities Finding the right balance between comfort and durability when selecting a backpacking pad, researching brands, and Carl's story of chasing a grizzly bear away from his campsite. (0:32:07) - Gear and Food for Backpacking Trips Essential gear for successful backpacking trips, including sleeping bags, tents, stoves, water filters, and food, are discussed, emphasizing budget and quality balance. (0:39:30) - Hiking Myths, Tips, and Gear We provide tips on backpacking, from rustling in the bushes to packing the right gear and food. (0:51:16) - Outdoor Enthusiasts & Handling Podcast Guests Researching sources, engaging in conversations, and respecting the platform are key when backpacking. (0:59:52) - Hiking, Basketball, and Adventure Goals Carl and his friends discussed hiking, basketball, backpacking, running shoes, gear, myths, and tips. (1:07:41) - Planning a Marathon and Traveling Setting goals for health, types of shoes and marathons, benefits of backpacking, and Carl's story of getting into backpacking. (1:11:27) - Discussion on Podcasting and Accountability Carl's journey, staying accountable, trail running, backpacking gear, myths and tips, researching sources, basketball, setting goals, and shoes for backpacking are discussed. Show Notes: https://wetflyswing.com/529