Podcasts about colloids

Time Artist Title Duration Album Year 0:00:00 ProgPhonic 174 Intro 0:39 2025 0:00:35 Walfad The Sons of Sisyphus 5:12 Colloids 2018 0:08:16 Timelock Artificial Intelligence (Akili Ya Bandia) 5:00 Atomic Swap 2024 0:13:17 Satellite Don't Walk Away in Silence 7:36 Into the Night 2008 0:20:53 Believe By My Tears 11:10 The Wyrding Way 2024 0:35:53 […]

In this conversation, Dennis, Doug, and Justin discuss the development of a Sepsis Clinical Practice Guideline (CPG) for prolonged field care. They highlight the importance of early recognition and antibiotic administration in sepsis management. They also discuss the use of scoring systems like QSOFA and NEWS2 to aid in the identification of septic patients. The conversation covers the role of lactate monitoring and the potential confounding factors. They emphasize the need for a comprehensive assessment of the patient and the importance of not relying solely on one marker or number. The conversation also touches on the importance of proper catheter insertion and the consideration of prophylactic catheter replacement in austere environments. They discuss the use of fluids as the first-line treatment in septic patients and caution against over-resuscitation. The conversation concludes with a reminder to pay attention to the patient's response and not blindly adhere to formulas or protocols. In this conversation, the speakers discuss various aspects of sepsis management, including fluid resuscitation, the use of colloids, the importance of monitoring urine output, and the decision to initiate vasopressors. They also touch on the use of antibiotics and wound management in sepsis cases. The conversation provides valuable insights and practical tips for healthcare providers in austere environments. Takeaways Early recognition and timely administration of antibiotics are crucial in sepsis management. Scoring systems like QSOFA and NEWS2 can aid in the identification of septic patients. Lactate monitoring can be confounded by various factors, and a comprehensive assessment of the patient is necessary. Proper catheter insertion and prophylactic catheter replacement should be considered in austere environments. Fluids are the first-line treatment in septic patients, but over-resuscitation should be avoided. Pay attention to the patient's response and use clinical judgment rather than blindly following formulas or protocols. In sepsis cases, fluid resuscitation is crucial, and the choice of fluid depends on availability. Balanced electrolyte solutions like Ringer's lactate or plasma light are preferred, but normal saline can be used if that's all that's available. Colloids may be used in sepsis patients with high output losses or compartment syndrome. Options include FFP, albumin, or freeze-dried plasma. Monitoring urine output is important in assessing the response to fluid resuscitation. If urine output increases, it indicates a positive response. However, if urine output remains high despite fluid administration, it may indicate over-resuscitation. When considering the use of vasopressors, the decision should be based on the patient's blood pressure and mental status. If the patient remains hypotensive and shows no improvement after a substantial amount of fluid, vasopressors may be initiated. Antibiotics should be given empirically in sepsis cases, and the choice of antibiotic depends on the suspected source of infection. Wound management, including effective debridement and irrigation, is crucial in preventing infection. Regular assessment of wounds is important to identify any signs of infection or non-viable tissue. In austere environments, it may be necessary to make treatment decisions based on the patient's clinical presentation and endemic risk, even without confirmatory tests. The conversation highlights the importance of collaboration and mentorship in developing clinical practice guidelines and acknowledges the contributions of healthcare professionals in the field. Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠ or ⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care

Beck's Hybrids Regional Agronomy Manager Jon Skinner explains what our #1 Priorities are in making practical yet economical decisions in determining what we can work on as it relates to our soil fertility, health, and chemistry. The health of corn and soybeans depends on this complex and delicate makeup of soil balance. Yet, Jon explains this so well in this video about how to approach this easily and simply. Watch this video and follow through with these step by step explanation on finding the answers you need for soil health and vitality. TOP Ag Services is a Beck's Hybrids seed dealer. We provide Hybrid Corn Seed, Soybean Seed, and Wheat Seed. Beck's has access to the best genetics and trait technologies from suppliers worldwide. We are the first to market with the best products & provide the latest, most accurate agronomic information through proven research. If you need agronomic assistance or want to be added to these updates, feel free to reach out via the messaging feature or contact us at topagservices.com/contact

OutlineChapter 14- Hypovolemic States- Etiology - True volume depletion occurs when fluid is lost from from the extracellular fluid at a rate exceeding intake - Can come the GI tract - Lungs - Urine - Sequestration in the body in a “third space” that is not in equilibrium with the extracellular fluid. - When losses occur two responses ameliorate them - Our intake of Na and fluid is way above basal needs - This is not the case with anorexia or vomiting - The kidney responds by minimizing further urinary losses - This adaptive response is why diuretics do not cause progressive volume depletion - Initial volume loss stimulates RAAS, and possibly other compensatory mechanisms, resulting increased proximal and collecting tubule Na reabsorption. - This balances the diuretic effect resulting in a new steady state in 1-2weeks - New steady state means Na in = Na out - GI Losses - Stomach, pancreas, GB, and intestines secretes 3-6 liters a day. - Almost all is reabsorbed with only loss of 100-200 ml in stool a day - Volume depletion can result from surgical drainage or failure of reabsorption - Acid base disturbances with GI losses - Stomach losses cause metabolic alkalosis - Intestinal, pancreatic and biliary secretions are alkalotic so losing them causes metabolic acidosis - Fistulas, laxative abuse, diarrhea, ostomies, tube drainage - High content of potassium so associated with hypokalemia - [This is a mistake for stomach losses] - Bleeding from the GI tract can also cause volume depletion - No electrolyte disorders from this unless lactic acidosis - Renal losses - 130-180 liters filtered every day - 98-99% reabsorbed - Urine output of 1-2 liters - A small 1-2% decrease in reabsorption can lead to 2-4 liter increase in Na and Water excretion - 4 liters of urine output is the goal of therapeutic diuresis which means a reduction of fluid reabsorption of only 2% - Diuretics - Osmotic diuretics - Severe hyperglycemia can contribute to a fluid deficit of 8-10 Iiters - CKD with GFR < 25 are poor Na conservers - Obligate sodium losses of 10 to 40 mEq/day - Normal people can reduce obligate Na losses down to 5 mEq/day - Usually not a problem because most people eat way more than 10-40 mEq of Na a day. - Salt wasting nephropathies - Water losses of 2 liters a day - 100 mEq of Na a day - Tubular and interstitial diseases - Medullary cystic kidney - Mechanism - Increased urea can be an osmotic diuretic - Damage to tubular epithelium can make it aldo resistant - Inability to shut off natriuretic hormone (ANP?) - The decreased nephro number means they need to be able to decrease sodium reabsorption per nephron. This may not be able to be shut down acutely. - Experiment, salt wasters can stay in balance if sodium intake is slowly decreased. (Think weeks) - Talks about post obstruction diuresis - Says it is usually appropriate rather than inappropriate physiology. - Usually catch up solute and water clearance after releasing obstruction - Recommends 50-75/hr of half normal saline - Talks briefly about DI - Skin and respiratory losses - 700-1000 ml of water lost daily by evaporation, insensible losses (not sweat) - Can rise to 1-2 liters per hour in dry hot climate - 30-50 mEq/L Na - Thirst is primary compensation for this - Sweat sodium losses can result in hypovolemia - Burns and exudative skin losses changes the nature of fluid losses resulting in fluid losses more similar to plasma with a variable amount of protein - Bronchorrhea - Sequestration into a third space - Volume Deficiency produced by the loss of interstitial and intravascular fluid into a third space that is not in equilibrium with the extracellular fluid. - Hip fracture 1500-2000 into tissues adjacent to fxr - Intestinal obstruction, severe pancreatitis, crush injury, bleeding, peritonitis, obstruction of a major venous system - Difference between 3rd space and cirrhosis ascities - Rate of accumulation, if the rate is slow enough there is time for renal sodium and water compensation to maintain balance. - So cirrhotics get edema from salt retension and do not act as hypovolemia - Hemodynamic response to volume depletion - Initial volume deficit reduced venous return to heart - Detected by cardiopulmonary receptors in atria and pulmonary veins leading to sympathetic vasoconstriction in skin and skeletal muscle. - More marked depletion will result in decreased cardiac output and decrease in BP - This drop in BP is now detected by carotid and aortic arch baroreceptors resulting in splanchnic and renal circulation vasoconstriction - This maintains cardiac and cerebral circulation - Returns BP toward normal - Increase in BP due to increased venous return - Increased cardiac contractility and heart rate - Increased vascular resistance - Sympathetic tone - Renin leading to Ang2 - These can compensate for 500 ml of blood loss (10%) - Unless there is autonomic dysfunction - With 16-25% loss this will not compensate for BP when patient upright - Postural dizziness - Symptoms - Three sets of symptoms can occur in hypovolemic patients - Those related to the manner in which the fluid loss occurs - Vomiting - Diarrhea - Polyuria - Those due to volume depletion - Those due to the electrode and acid base disorders that can accompany volume depletion - The symptoms of volume depletion are primarily related to the decrease in tissue perfusion - Early symptoms - Lassitude - Fatiguability - Thirst - Muscle cramps - Postural dizziness - As it gets more severe - Abdominal pain - Chest pain - Lethargy - Confusion - Symptomatic hypovolemia is most common with isosmotic Na and water depletion - In contrast pure water loss, causes hypernatremia, which results in movement of water from the intracellular compartment to the extracellular compartment, so that 2/3s of volume loss comes from the intracellular compartment, which minimizes the decrease in perfusion - Electrolyte disorders and symptoms - Muscle weakness from hypokalemia - Polyuria/poly dips is from hyperglycemia and hypokalemia - Lethargy, confusion, Seizures, coma from hyponatremia, hypernatremia, hyperglycemia - Extreme salt craving is unique to adrenal insufficiency - Eating salt off hands ref 18 - Evaluation of the hypovolemic patient - Know that if the losses are insensible then the sodium should rise - Volume depletion refers to extracellular volume depletion of any cause, while dehydration refers to the presence of hypernatremia due to pure water loss. Such patients are also hypovolemic. - Physical exam is insensitive and nonspecific - Finding most sensitive and specific finding for bleeding is postural changes in blood pressure - I don't find this very specific at all! - Recommends laboratory confirmation regardless of physical exam - Skin and mucous membranes - Should return too shape quickly - Elastic property is called Turgur - Not reliable is patients older than 55 to 60 - Dry axilla - Dry mucus membranes - Dark skin in Addison's disease Frim increased ACTH - Arterial BP - As volume goes down so does arterial BP - Marked fluid loss leads to quiet korotkoff signs - Interpret BP in terms of the patients “normal BP” - Venous pressure - Best done by looking at the JVP - Right atrial and left atrial pressure - LV EDP is RAP + 5 mmHg - Be careful if valvular disease, right heart failure, cor pulmonare, - Figure 14-2 - Shock - 30% blood loss - Lab Data - Urine Na concentration - Should be less than 25 mmol/L, can go as low as 1 mmol/L - Metabolic alkalosis can throw this off - Look to the urine chloride - Figure 14-3 - Renal artery stenosis can throw this off - FENa - Mentions that it doesn't work so well at high GFR - Urine osmolality - Indicates ADH - Volume depletion often associated with urine osm > 450 - Impaired by - Renal disease - Osmotic diuretic - Diuretics - DI - Mentions that severe volume depletion and hypokalemia impairs urea retension in renal medulla - Points out that isotonic urine does not rule out hypovolemia - Mentions specific gravity - BUN and Cr concentration - Normal ratio is 10:1 - Volume depletion this goes to 20:1 - Serum Na - Talks about diarrhea - Difference between secretory diarrhea which is isotonic and just causes hypovolemia - And osmotic which results in a lower electrolyte content and development of hypernatremia - Talks about hyperglycemia - Also can cause the sodium to rise from the low electrolyte content of the urine - But the pseudohyponatraemia can protect against this - Plasma potassium - Treatment - Both oral and IV treatment can be used for volume replacement - The goal of therapy are to restore normovolemia - And to correct associated acid-base and electrolyte disorders - Oral Therapy - Usually can be accomplished with increased water and dietary sodium - May use salt tablets - Glucose often added to resuscitation fluids - Provides calories - Promotes intestinal Na reabsorption since there is coupled Na and Glucose similar to that seen in the proximal tubule - Rice based solutions provide more calories and amino acids which also promote sodium reabsorption - 80g/L of glucose with rice vs 20 g/L with glucose alone - IV therapy - Dextrose solutions - Physiologically equivalent to water - For correcting hypernatremia - For covering insensible losses - Watch for hyperglycemia - Footnote warns against giving sterile water - Saline solutions - Most hypovolemic patients have a water and a sodium deficit - Isotonic saline has a Na concentration of 154, similar to that of plasma see page 000 - Half-isotonic saline is equivalent to 550 ml of isotonic saline and 500 of free water. Is that a typo? - 3% is a liter of hypertonic saline and 359 extra mEq of Na - Dextrose in saline solutions - Give a small amount of calories, otherwise useless - Alkalinizing solutions - 7.5% NaHCO3 in 50 ml ampules 44 mEq of Na and 44 mEq of HCO3 - Treat metabolic acidosis or hyperkalemia - Why 44 mEq and not 50? - Do not give with calcium will form insoluble CaCO3 - Polyionic solutions - Ringers contains physiologic K and Ca - Lactated Ringers adds 28 mEq of lactate - Spreads myth of LR in lactic acidosis - Potassium chloride - Available as 2 mEq/mL - Do not give as a bolus as it can cause fatal hyperkalemia - Plasma volume expanders - Albumin, polygelastins, hetastarch are restricted to vascular space - 25% albumin can pull fluid into the vascular space - 25% albumin is an albumin concentration of 25 g/dL compare to physiologic 4 g/dL - Says it pulls in several times its own volume - 5% albumin is like giving plasma - Blood - Which fluid? - Look at osmolality, give hypotonic fluids to people with high osmolality - Must include all electrolytes - Example of adding 77 mEw of K to 0.45 NS and making it isotonic - DI can be replaced with dextrose solutions, pure water deficit - Case 14-3 - Diarrhea with metabolic acidosis - He chooses 0.25 NS with 44 mEq of NaCl and 44 NaHCO3 - Talks about blood and trauma - Some studies advocate delaying saline until penetrating trauma is corrected APR about to. Keep BP low to prevent bleeding. Worry about diluting coagulation factors - Only do this if the OR is quickly available - Volume deficit - Provides formula for water deficit and sodium deficit - Do not work for isotonic losses - Provides a table to adjust fluid loss based on changes in Hgb or HCTZ - Says difficult to estimate it from lab findings and calculations - Follow serial exams - Serial urine Na - Rate of replacement - Goal is not to give fluid but to induce a positive balance - Suggests 50-100 ml/hr over what is coming out of the body - Urine - Insensibles 30-50 - Diarrhea - Tubes - Hypovolemic shock - Due to bleeding - Sequesting in third space - Why shock? - Progressive volume depletion leads to - Increased sympathetic NS - Increased Ang 2 - Initially this maintains BP, cerebral and coronary circulation - But this can decrease splanchnic, renal and mucocutaneous perfusion - This leads to lactic acicosis - This can result in intracellular contents moving into circulation or translocation of gut bacteria - Early therapy to prevent irreversible shock - In dogs need to treat with in 2 hours - In humans may need more than 4 hours - Irreversible shock associated with pooling of blood in capillaries - Vasomotor paralysis - Hyperpolarization of vascular smooth muscle as depletion of ATP allows K to flowing out from K channels opening. Ca flows out too leading to vasodilation - Glyburide is an K-ATP channel inhibitor (?) caused increased vasoconstriction and BP - Pluggin of capillaries by neutrophils - Cerebral ischemia - Increased NO generation - Which Fluids? - Think of what is lost and replace that. - Bleeding think blood - Raise the hct but not above 35 - Acellular blood substitutes, looked bad at the time of this writing - Di aspirin cross linked hemoglobin had increased 2 and 28 day mortality vs saline - Colloids sound great but they fail in RCTs - SAFE - FEAST - Points out that saline replaces the interstitial losses why do we think those losses are unimportant - Pulmonary circulation issue - Pulmonary circulation is more leaky so oncotic pressure less effective there - Talks about the lungs be naturally protected from pulmonary edema - Rate of fluid - 1-2 liters in first hour - Suggests CVP or capillary wedge pressure during resuscitation - No refs in the rate of fluid administration section - Lactic acidosis - Points out that HCO can impair lactate utilization - Also states that arterial pH does not point out what is happening at the tissue level. Suggests mixed-venous sample.ReferencesJCI - Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia and a nice review of this topic: Altered Prostaglandin Signaling as a Cause of Thiazide-Induced HyponatremiaThe electrolyte concentration of human gastric secretion. https://physoc.onlinelibrary.wiley.com/doi/10.1113/expphysiol.1960.sp001428A classic by Danovitch and Bricker: Reversibility of the “Salt-Losing” Tendency of Chronic Renal Failure | NEJMOsmotic Diuresis Due to Retained Urea after Release of Obstructive Uropathy | NEJMIs This Patient Hypovolemic? | Cardiology | JAMAAnd by the same author, a textbook: Steven McGee. 5th edition. Evidence-Based Physical Diagnosis Elsevier Philadelphia 2022. ISBN-13: 978-0323754835The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report | BMC Endocrine DisordersSensitivity and specificity of clinical signs for assessment of dehydration in endurance athletes | British Journal of Sports MedicineDiagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department | BMC NephrologyThe meaning of the blood urea nitrogen/creatinine ratio in acute kidney injury - PMCLanguage guiding therapy: the case for dehydration vs volume depletion https://www.acpjournals.org/doi/10.7326/0003-4819-127-9-199711010-00020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedValidation of a noninvasive monitor to continuously trend individual responses to hypovolemiaReferences for Anna's voice of God on Third Spacing : Shires Paper from 1964 (The ‘third space' – fact or fiction? )References for melanie's VOG:1. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association2. excellent review of RAAS in pregnancy: The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone systemhttps://journals-physiology-org.ezp-prod1.hul.harvard.edu/doi/full/10.1152/ajprenal.00129.20163. 10.1172/JCI107462- classic study in JCI of AngII responsiveness during pregnancy4. William's Obstetrics 26th edition!5. Feto-maternal osmotic balance at term. A prospective observational study

Colloids are often misunderstood and take a backseat to crystalloids. The following episode dives into their mechanism of action and the critical role they play in maintaining colloidal osmotic pressure. Albumin takes center stage in the episode as one of the primary colloids administered in the ICU. 

What are we observing versus what are we supposed to see, in other words, how (and how much) is dogma directing our interpretations? We explore this concept this month when we delve into Duncan McLeish's PhD work on the transport and deposition of gold at the Brucejack Deposit (Canada). In a world where aqueous complexation has long been considered the only viable means of transporting gold to depositional sites in hydrothermal ore-forming systems, Duncan et al. found that rejecting dogma was of the utmost importance. For example, a major weakness of the Au transport in solution hypothesis is that it cannot readily explain the formation of ultrahigh-grade gold veins when transporting Au at ppb levels. ...so how do “bonanza” veins contain weight-percent levels of gold in some epithermal and orogenic deposits? ...what are colloids and flocculation? ...why is this research both exciting and important? All this and more in this episode! Put on your thinking caps, it's time to listen to some applied chemistry, economic geology and a little bit of philosophy. For this episode we read "Colloidal transport and flocculation are the cause of the hyperenrichment of gold in nature" by McLeish et al., 2021. --- Support this podcast: https://anchor.fm/geochemistea/support

Quantum Dots contain only a few hundred atoms. Because the electrons in a quantum dot are confined to widely separated energy levels, the dot emits only one wavelength of light when excited. The size of the dot determines its electronic, magnetic, and optical properties. Quantum Dot Corporation has developed a QD cadmium selenide nanoparticle for use as biological labels. Researchers can tag proteins and nucleic acids with QD and illuminate them with ultraviolet light and the crystal will fluoresce at a specific wavelength and show the location of attached proteins. How does a QD work? An organic dye molecule absorbs only photons of light with just the right energy to lift its electrons from their quiescent state to one of the higher levels available to them. The incident light must be exactly the right wavelength or color. The molecule will emit a photon when the electron falls to a lower energy level. Colloids: nanoparticles in suspension. IBM is exploring using colloids to build ultrahigh density data storage. IBM is using colloids containing magnetic nanoparticles 3 nm across, each composing of about 1,000 iron and platinum atoms. The colloid is spread on a surface and the solvent allowed to evaporate and these nanoparticles crytalize into 2 or 3 dimensional arrays. These arrays could hold trillions of bits per square inch. Cantilevers: IBM is exploring using atomic force microscopes to screen samples for certain genetic sequences. They attach short strands of DNA to the tops of cantilevers. When genetic material carrying a complementary sequence binds to the anchored strands, it induces a surface stress, which bends the cantilevers subtly, by use nanometers, but enough for detection. Dendrimers: An dendrimer is an artifical molecule. Dendrimers are globular molecules about the size of a typical protein, but they do not come apart or unfold because they are held together with stronger chemical bonds. Dendrimers can be engineered to transport DNA into cells for gene therapy. Dendrimers offer control. It may be possible to design dendrimers that spontaneously swell and liberate their contents oly when the appropriate trigger molecules are present. This ability would allow a custom-made dendrimer to release its load of drugs I just the tissues or organs needing treatment. Nanoshells: Nanoshells are extremely small beads of glass coated with gold. Nanoshells capture energy in near-infrared fashion. Such a nanoshell could be made to deliver drug molecules at specific times by attaching it to a capsule made of heat-sensitive polymer. The capsule would release its contents only when gentle heating of the attached nonshell caused it to deform. Another more dramatic application envisions connecting nanoshells with antibodies. The antibodies attach to the tumor cells and the nanoshells are heated using high power infrared sufficiently to destroy the cancer cells, while leaving nearby tissue unharmed. --- Send in a voice message: https://anchor.fm/david-nishimoto/message

In this episode, Bea continues her conversation with Prof. Dr Peter Seeberger, a managing director at the Max Planck Institute for Colloids and Interfaces, about carbohydrate-based vaccines. They talk about the current vaccine market and its future potential, the traditional field of vaccinology, and the obstacles one faces when trying to introduce change to an established product market. Peter talks about developing antibodies and using them in creating cancer vaccines, and the different tasks involved in designing the vaccines for treatment and prevention, i.e. for cancer patients versus for the general population. Peter talks more about the companies that have been founded by his lab, about the successes, the failures, the lessons learned along the way, and the opportunities that such start-ups offer to make new tools available for a larger population and to expand a research field. Peter and Bea also discuss how recent years have shown the fundamental importance of chemistry in all areas of our lives. Learn more about Prof. Dr. Seeberger's lab and research here: https://www.mpikg.mpg.de/en/bs and https://www.peter-seeberger.de Cover Photo: © Sebastian Rost / Max-Planck-Institut für Kolloid- und Grenzflächenforschung Episode Art: Photo by Photo by Louis Reed(@_louisreed) on Unsplash (https://unsplash.com/) You can follow us on: Twitter: https://twitter.com/MPPhdnetPodcast Instagram: https://www.instagram.com/offspringmagazine_thepodcast Linkedin: https://www.linkedin.com/company/offspring-magazine-the-podcast YouTube: https://youtube.com/c/MaxPlanckPhDnet If you have any feedback, comments, or suggestions, reach out to us at offspring.podcasts@phdnet.mpg.de Check out the Offspring-Blog where we publish articles on a regular basis: https://www.phdnet.mpg.de/outreach/offspring-blog Intro - Outro music composed by Srinath Ramkumar: https://twitter.com/srinathramkumar Pre-Intro jingle composed by Gustavo Carrizo: https://www.instagram.com/carrizo.gus See you soon!

In this episode, Bea talks to Prof. Dr. Peter Seeberger, a managing director at the Max Planck Institute for Colloids and Interfaces, about carbohydrate-based vaccines. Peter talks about how the research he has done for the past 27 years led to the development of a tool for the automated synthesis of carbohydrates. He talks about creating the synthesizer even when people did not believe that it could be possible, and explains how the synthesizer can be used in a variety of chemical fields, for example, in creating synthetic carbohydrate-based vaccines. Peter explains the history of vaccines, talks about their development and how it has changed through the years, and also discusses the future of the field of vaccines, both with regard to the design of synthetic vaccines and the growing vaccine market for animals. Peter also talks about the spin-off companies and currently used vaccines that the research in his laboratory has resulted in. Learn more about Prof. Dr. Seeberger's lab and research here: https://www.mpikg.mpg.de/en/bs and https://www.peter-seeberger.de Cover Photo: © Sebastian Rost / Max-Planck-Institut für Kolloid- und Grenzflächenforschung Episode Art: Photo by Photo by Mat Napo (@matnapo) on Unsplash (https://unsplash.com/) You can follow us on: Twitter: https://twitter.com/MPPhdnetPodcast Instagram: https://www.instagram.com/offspringmagazine_thepodcast Linkedin: https://www.linkedin.com/company/offspring-magazine-the-podcast YouTube: https://youtube.com/c/MaxPlanckPhDnet If you have any feedback, comments, or suggestions, reach out to us at offspring.podcasts@phdnet.mpg.de Check out the Offspring-Blog where we publish articles on a regular basis: https://www.phdnet.mpg.de/outreach/offspring-blog Intro - Outro music composed by Srinath Ramkumar: https://twitter.com/srinathramkumar Pre-Intro jingle composed by Gustavo Carrizo: https://www.instagram.com/carrizo.gus See you soon!

Season 5 Early Doors - Episode 8 Nick and Steve are waking up early to have a science chitchat before work... this week Steve's got the horn for Michael Faraday's Colloids and Nick is off swanning off to Asia. If you like TheScienceShed, the best thing you can do is share it on social media, and to follow us all on twitter, and please leave us a rating or review on iTunes! twitter @SteveTheChemist, @theevanslab & @TheScienceShed

In this episode, Bea talks to Prof. Dr. Dr. h.c. Markus Antonietti, a director of Max Planck Institute of Colloids and Interfaces, about his kitchen lab and the projects that are carried out within it. Markus tells the history of the kitchen lab, from its conception as a teaching tool for children to its current form as a research space, where kitchen utensils and cooking techniques can be used for chemical processes, and why this is a way toward more sustainable and practical chemistry. Markus talks about the setup of the kitchen lab and describes a number of projects that have been carried out within it as well as some that are still ongoing, including creating a circular economy of wood, the extraction of resveratrol in the kitchen environment as a replacement for BPA, encapsulation processes of perfume and oils for cosmetics, and improving the texture of vegan burgers. Markus highlights the numerous advantages as well as some limitations that his kitchen lab has and explains how it fits into the Max Planck Research Community. Check out the Kitchen Lab here: https://www.mpikg.mpg.de/kitchen-lab Episode Art: Photo by Nicolas Gras (@armgd) on Unsplash (https://unsplash.com/) You can follow us on: Twitter: https://twitter.com/MPPhdnetPodcast Instagram: https://www.instagram.com/offspringmagazine_thepodcast Linkedin: https://www.linkedin.com/company/offspring-magazine-the-podcast YouTube: https://youtube.com/c/MaxPlanckPhDnet If you have any feedback, comments, or suggestions, reach out to us at offspring.podcasts@phdnet.mpg.de Check out the Offspring-Blog where we publish articles on a regular basis: https://www.phdnet.mpg.de/outreach/offspring-blog Intro - Outro music composed by Srinath Ramkumar: https://twitter.com/srinathramkumar Pre-Intro jingle composed by Gustavo Carrizo: https://www.instagram.com/carrizo.gus See you soon!

This is the podcast where we “Scale up on knowledge so we don't scale up our systems.” I'm your host, Trace Blackmore, and today, I want to motivate you to be your best self this year.  Before we dive in, I want to ask you a couple of questions: What do you want to accomplish in 2022?  How are you going to accomplish what you set out to do?  What is your motivation for wanting that accomplishment?  How will you celebrate once you achieve your goals? Today, I'm going to walk through the strategies the Rising Tide Mastermind uses to accomplish our goals, and we will also be using THIS strategy from Brian Moran's book, 12 Week Year.   Bottom line: I'm challenging you to stop living in default mode, and to truly stretch yourself to grow personally and professionally. Your roadside friend, as you travel from client to client.   -Trace    Timestamps:  Don't live life by default [2:00] How The Rising Tide Mastermind members make goals and plans [3:20] It all starts with the review [8:15] A word of caution [12:20] Planning 3 years out [15:00] Goals for these 5 areas: Personal, Spiritual, Relational, Professional, Financial [18:50] Leveraging the “12 Week Year” [28:20] Using your calendar as a tool [34:00] Writing it down and sharing it [40:00] Thinking On Water with James [42:02] #TOW22   Thinking On Water with James: Control Ranges In this week's episode, we're thinking about control ranges for testing readings both you and your customer run and monitor. How many control ranges are enough, and when do you reach overkill? What are the key performance indicators? Should you set control ranges on tests and readings you cannot control, or do you set them anyway so you are warned to take action downstream? How tight are your control ranges? Can the controller maintain them? Are the test procedures used accurate enough to achieve them? Are the control ranges so broad a truck can drive through them? Take this week to think about your control ranges, and what you are really trying to accomplish. Each control range should have a solid reason why behind it.   Quotes: “So many of us are so eager to start something new that we don't take into account what life is teaching us.” - Trace Blackmore “Make sure you stretch yourself this year; that's where the personal growth will happen.” - Trace Blackmore “Now might not be the right time.” - Trace Blackmore “Are these goals appropriate for the season of life you are in right now?” - Trace Blackmore “Any goal you push off could lose steam.”  - Trace Blackmore “The hardest thing in this process is moving that first domino.” - Trace Blackmore “Be specific and intentional about what you want to accomplish and write them down.” - Trace Blackmore “Life is dynamic; your schedule needs to be dynamic as well.”  - Trace Blackmore “Accountability: it takes things out of your head and allows others to know about it.” - Trace Blackmore   Connect with Scaling UP H2O:  Email: corrine@blackmore-enterprises.com (podcast producer) Submit a show idea: Submit a Show Idea Scaling UP! H2O on LinkedIn: company/scalinguph2o Scaling UP! H2O on Facebook: @H2OScalingUP   Links Mentioned:  122 The One with Reid Hutchison 232 The One Where We Celebrate What We Learned In 2021 092 The One About My TED Talk Experience The Rising Tide Mastermind Submit a Show Idea AWT (Association of Water Technologies)   Events: The Hang Networking Event- @6pm EST, USA January 20, 2022 WEF (Water Environment Federation) Forum 2022 – Particles and Colloids – the Next Frontier in Intensifying Water Resource Recovery – January 10 to 12, 2022  2022 ABMA (American Boiler Manufacturers Association) Annual Meeting – January 14 to 17, 2022     Books Mentioned: The 12 Week Year Check Out Our Resources Page For Discounts  

Gudrun spricht in dieser Folge mit Pauline Brumm von der TU Darmstadt über Benetzung im Tiefdruck. Sie ist wissenschaftliche Mitarbeiterin am Institut für Druckmaschinen und Druckverfahren und promoviert im SFB 1194 zur Mechanischen Zwangsbenetzung von Oberflächen durch gravierte Tiefdruckzylinder im Teilprojekt C01. Es handelt sich um eine Weiterführung des Gesprächs mit Dr. Mathis Fricke im Modellansatz-Podcast Folge 242 über Dynamische Benetzung. Herr Fricke hatte über die Arbeit im SFB 1194 aus Sicht der Mathematik berichtet, Frau Brumm liefert in dieser Folge nun einen Beitrag aus Sicht der Anwendung. Sie hat Maschinenbau im Bachelor und Master an der TU Darmstadt studiert und sich auf Drucktechnik spezialisiert. Drucken wird seit hunderten von Jahren praktiziert und angewendet, jedoch gibt es bisher noch keine umfassende Modellbildung für viele Druckprozesse. Das bedeutet, dass ein Großteil des Wissens empirisch geprägt ist. Firmen stützen sich auf die Erfahrung von gelernten Drucktechnikern, jedoch ist diese Erfahrung nur selten öffentlich zugänglich und es gibt wenige Forschungsinstitute weltweit zum Thema Drucktechnik. Um innovative Anwendungen zu entwickeln, zum Beispiel aus dem Bereich der gedruckten Elektronik, bedarf es jedoch einer detaillierten Modellvorstellung des Druckprozesses, um klassische Druckverfahren aus dem grafischen Druck (Zeitungsdruck, Verpackungsdruck etc.) für den sogenannten „funktionalen Druck“ nutzbar zu machen. Die Schwierigkeit liegt darin, dass an den funktionalen Druck ganz andere Anforderungen gestellt werden, zum Beispiel müssen die gedruckten, häufig ultradünnen Schichten geschlossen, fehlerfrei und von konstanter Schichtdicke sein. Ein häufiger Druckfehler ist das sogenannte „Viscous Fingering“, eine hochdynamische Grenzflächeninstabilität bei der Fluidübertragung, die sich in Form von faszinierenden, verästelten, fingerartigen Strukturen in der gedruckten Schicht bemerkbar macht. Sie sehen so ähnlich aus wie die Arme eines Flussdeltas aus Vogelperspektive oder die Wurzeln von Bäumen. In ihrer Forschung untersucht Frau Brumm diese verästelten Strukturen im Tiefdruck, um sie besser zu verstehen und um den Druckfehler in Zukunft zu verhindern oder für spezielle Anwendungen nutzbar zu machen. Beim Tiefdruck wird die Farbe über gravierte Näpfchen in einem Druckzylinder übertragen. Die Näpfchen liegen vertieft und sind nur wenige zehn Mikrometer groß. Beim Kontakt mit dem zu bedruckenden Substrat (Papier, Folie, Glas…) wird die Druckfarbe unter hohem Druck und hoher Geschwindigkeit aus den Näpfchen herausgesaugt. Es kommt zur Zwangsbenetzung des Substrats. Mit Stokes-Gleichungen kann man Parametermodelle herleiten, welche das Skalierungsverhalten der verästelten, gedruckten Strukturen beschreiben. Zum Beispiel skaliert der dominante Abstand der gedruckten Strukturen mit der Druckgeschwindigkeit hoch minus ein Halb laut Sauer et al. (2015), welches dem 60 Jahre alten Skalengesetz von Saffman und Taylor (1958) entspricht. Mit Experimenten können diese Modelle bestätigt oder widerlegt werden. Die Planung von Experimenten geschieht zielgerichtet. Im Vorfeld muss überlegt werden, welche Parameter im Experiment variiert werden sollen und wie viele Messpunkte benötigt werden, um statistisch abgesicherte Aussagen treffen zu können. Meistens ist die Herausforderung, die Vielzahl der Parameterkombinationen auf ein Minimum zu reduzieren und dennoch die gewünschten Aussagen treffen zu können. Die gedruckten Proben werden hochauflösend mit einem Flachbettscanner digitalisiert und danach werden Bildverarbeitungsmethoden in den ingenieurstypischen Programmiersprachen Matlab oder Python angewendet. Beispielsweise wird eine Fast Fourier Transformation (FFT) benutzt, um den dominanten Abstand der gedruckten Strukturen zu ermitteln. Die Automatisierung des Experiments und vor allem der anschließenden Auswertung ist ein weiterer wichtiger Punkt. Um zehntausende von gedruckten Mustern zu analysieren, wurde ein hochautomatisierter computergestützter Workflow entwickelt. Seit kurzem wird von Frau Brumm auch Künstliche Intelligenz, genauer gesagt Deep Learning, zur Klassifizierung der gedruckten Muster verwendet. Dies ist notwendig, um die Skalierbarkeit hin zu industriellen Prozessen zu ermöglichen, indem umfangreiche Versuchsreihen an industriellen Maschinen durchgeführt und automatisiert ausgewertet werden. Diese werden anschließend mit kleineren Versuchsreihen an speziell entwickelten Labormaschinen verglichen, bei denen teilweise auch Modellfluide anstelle von realen Druckfarben verwendet werden. Bei Laborexperimenten werden in Teilprojekt C01 im SFB 1194 auch Hochgeschwindigkeitsvideos der hochdynamischen Grenzflächeninstabilität aufgenommen, die noch tiefere Einblicke in die Strömungsdynamik bieten und die industriellen Experimente ergänzen und erklären sollen. Der Maschinenbau ist sehr breit gefächert und das Studium muss dementsprechend auch breite Kenntnisse vermitteln. Beispielsweise werden umfangreiche Methoden aus der Mathematik gelehrt, damit ein/e Maschinenbau-Absolvent/in für die diversen Anwendungsaufgaben gerüstet ist. In der modernen Forschung ist die Fähigkeit zur interdisziplinären Zusammenarbeit und zur Wissenschaftskommunikation sehr entscheidend. Maschinenbauer/innen im SFB 1194 arbeiten beispielsweise mit Mathematikern/innen, Physikern/innen und Informatikern/innen zusammen, um eine größere Forschungsfrage zu beantworten. In dieser Podcast-Folge wird auch an junge Frauen appelliert, ein MINT-Studium auszuprobieren, um mehr Diversität im Studium, Forschung und Industrie zu erreichen, um am Ende noch innovativere Lösungen zu schaffen, die der Welt einen Nutzen bringen. Literatur und weiterführende Informationen Pauline Brumm, Tim Eike Weber, Hans Martin Sauer, and Edgar Dörsam: Ink splitting in gravure printing: localization of the transition from dots to fingers. J. Print Media Technol. Res. Vol. 10 No. 2 (2021), 81-93 Pauline Brumm, Hans Martin Sauer, and Edgar Dörsam: Scaling Behavior of Pattern Formation in the Flexographic Ink Splitting Process. Colloids and Interfaces, Vol. 3 No. 1 (2019), 37 Hans Martin Sauer; Dominik Daume, and Edgar Dörsam: Lubrication theory of ink hydrodynamics in the flexographic printing nip. Journal of Print and Media Technology Research, Vol. 4 No. 3 (2015), 163-172 Julian Schäfer, Ilia V. Roisman, Hans Martin Sauer, and Edgar Dörsam: Millisecond fluid pattern formation in the nip of a gravure printing machine. Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 575 (2019), 222-229 Philip Geoffrey Saffman, and Geoffrey Ingram Taylor: The penetration of a fluid into a porous medium or Hele-Shaw cell containing a more viscous liquid. Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences Vol. 245 No. 1242 (1958), 312-329 Podcasts M. Fricke, G. Thäter: Dynamische Benetzung, Gespräch im Modellansatz Podcast, Folge 242, Fakultät für Mathematik, Karlsruher Institut für Technologie (KIT), 2021. M. Haragus, G. Thäter: Pattern Formation, Conversation im Modellansatz Podcast, Episode 227, Department of Mathematics, Karlsruhe Institute of Technology (KIT), 2019. S. Winter: Fraktale Geometrie, Gespräch mit G. Thäter im Modellansatz Podcast, Folge 120, Fakultät für Mathematik, Karlsruher Institut für Technologie (KIT), 2016. S. Lerch, G. Thaeter: Machine Learning, Gespräch im Modellansatz Podcast, Folge 232, Fakultät für Mathematik, Karlsruher Institut für Technologie (KIT), 2020.

Episode 16 of the Modern Chemistry podcast dives back into glycobiology and its practical application with Benjamin Schumann. Ben is a chemical biologist who studies the biology of carbohydrates (glycans). After completing his undergraduate biochemistry studies in Tübingen, Germany, he was trained in synthetic carbohydrate chemistry in the lab of Peter H. Seeberger at the Max Planck Institute of Colloids and Interfaces Potsdam and the FU Berlin. Developing vaccines against pathogenic bacteria based on synthetic glycans, Ben learned to apply his compounds in biological settings in vivo and in vitro. For his achievements, he received the Award for Excellence in Glycosciences and, in 2017, the prestigious Otto Hahn Medal by the Max Planck Society. During his postdoctoral work in the lab of Carolyn R. Bertozzi at Stanford University as an Alexander von Humboldt foundation Feodor Lynen fellow, Ben developed an interest in "precision tools" to study glycosylation of human cells in great detail. He started as a Group Leader at the Crick and Imperial College London in 2018.Towards the end of the show, Ben mentions a prize. Ben and colleagues from Imperial College and Stanford University were awarded the Royal Society of Chemistry's new Chemistry Biology Interface Division Horizon Prize, the Rita and John Cornforth Award. For more details, please check out this link on the Francis Crick Institute's website - https://www.crick.ac.uk/news/2021-06-08_research-prize-for-chemical-toolbox-to-study-the-role-of-cell-surface-sugars. You will hear the following terms used during the interview. I've included some descriptions here. Glycobiology - the study of complex sugar molecules in biological systems and cells.Glycobiome/glycoproteome – the total glycan make-up of a cell or organismGlycosylation – the addition of sugar molecules to other substances, often proteins.Glycans – complex sugar molecules composed of single sugar sub-units linked by chemical bondsChemical biology – the application of chemical techniques, and often small molecules produced by chemistry to study biological processes.Biochemistry – the study of biomolecules and pathways in living systemsLectins – highly specific carbohydrate-binding proteinsAntibody – a 'Y'-shaped protein produced by the immune system which identifies and binds to a specific substanceMonosaccharide – a single sugar subunitBioorthogonal chemistry – a chemical reaction that occurs in a living system without interfering with natural biochemistryGlycosyl transferase – enzymes which add a sugar (simple or complex) to an acceptor moleculeChemoenzymatic synthesis – producing chemical using biochemical pathways within cellsCRISPR - CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, a family of specific DNA sequences in prokaryotes. Enzymes, such as 'Cas9' can modify DNA at these CRISPR sequences, editing in or out new DNA sequences. Although this technique is known correctly as CRISPR-Cas9, the discovery and development of a range of CRISPR-associated enzymes has led to the term 'CRISPR' being used as a generic term for this suite of gene editing technologies.Isoenzymes – enzymes that catalyse the same reaction, but have different amino acid sequencesProteolytic digest – breaking up a protein, or peptide, chain into smaller fragmentsFluorophore – a fluorescent molecule (in this case, used as a reporter molecule)Biotin tag – a chemical molecule used as a reporter for other biomoleculesBio-organic chemistry – scientific studies combining organic chemistry and biochemistry, which studies biological processes using chemical methods.

As the fourth quarter of 2021 draws to a close, what are the things you are evaluating to make sure that Q4 ends well and that 2022 is going to be a more profitable year for you and your company? If you have ever wondered: how much money should the company have in the bank, why are we taking on more clients but not making a profit, or why are we spending more money on the company but not seeing the payoff, then today's episode is for you. Today's guest is Russ Stephens, co-founder of the Association of Professional Builders, a leading business coaching company dedicated to improving the residential construction industry for both builders and consumers.  Since 2014 he has been helping builders double the size of their businesses through profitable growth. The Association Of Professional Builders excels in providing cutting-edge systems, world-class support, and sales & marketing training to the construction industry. And Russ knows how to do this because he uses data to make the right decisions to increase profits.  Bottom line: Russ is going to give you the data your company needs to be looking at to make the right decisions. Your roadside friend, as you travel from client to client.   -Trace    Timestamps:  Get to know Russ Stephens, the man who moved to Australia and grew an entire industry's profits with data [6:00] Understand the true financials as a business owner [11:40] What are the core numbers we need to be looking at [15:13] The most important thing to look at to scale  [22:10] How much money should a business have in the bank [25:00]  What formula should a business use to budget for marketing [27:37]  The importance of KPIs and SOPS [29:32] Understanding today's consumers to generate more business  [31:20] Lightning round questions [37:15] James' Challenge: “ Ask your customer what you can do better.”  [47:08]   Quotes: “Margins are linked to marketing.” - Russ Stephens “The backbone to any good company is SOPs or Standard Operating Procedures.” - Russ Stephens “As a business owner, you cannot be a micromanager. You need to only look for the gaps in the system and address them.” - Russ Stephens “The internet turned the sales process on its head over a decade ago. Consumers are more educated than any generation in history, so we need to become the online provider of information. We need to educate the consumer before we sell to them.” - Russ Stephens   Connect with Russ Stephens: Phone: +61450519613 Email: Russ@apbbuilders.com Website: associationofprofessionalbuilders.com LinkedIn: in/russstephens   Links Mentioned: scalinguph2o.com/audible  Industrial Water Week 2022 starts Oct 3rd Episode 204 on being profitable Episode 101 with Colin Frayne Episode 102 with Colin Frayne The Rising Tide Mastermind   Events: The Hang Networking Event- @6pm  November 11 2021 NGWA Groundwater Summit - 12.7 and 12.8.21 Forum 2021 Particles and Colloids - 1.10 -1.12.22   Books Mentioned: Procrastinate on Purpose: 5 Permissions to Multiply Your Time -by Rory Vaden Powered By Change - by Nicholas Brealey Influence - by Robert B. Cialdini Psycho-Cybernetics - by Maxwell Maltz  

Dr. Conner talks about the great colloid scandal of 2010 starring Joachim Boldt. Host: Dr. Bobbi Conner Producer: Topher Conlan

Between the latest online fads and the crazy media headlines, it’s easier than ever to get confused about your health. If you want to make better decisions about your health today so you can feel better and live longer, you’ve come to the right place. A listener asks, “What are your favorite brands of Silver Sol or Colloidal Silver? And is there a difference between those types of Silver, or are they two different names for the same thing?” Let us learn more about Silver and Colloidal Silver, their bearings in the medical field, particularly in COVID prevention.   Key Takeaways: History of Silver, its properties, and generalization (01:16) What is Silver? (02:08) What are Colloids and Colloidal Silver? (02:38) History of Silver in medical practices (03:19) Colloidal Silver in medical practices (05:20) Studies on the antibacterial, antiviral, antifungal activity of Colloidal Silver (06:13) Colloidal Silver interferes with thyroid medication (07:04) Colloidal Silver interferes with antibiotics (07:30) “Is Silver harmful?” Argyria & Argyrosis (07:46) Silver toxicology reports on animals and humans (10:54) Oral toxicity of Silver (11:17) Kidney damage and other medical issues caused by Silver (15:13) Study on health effects and complications of using Silver (17:04) “At what threshold is it dangerous?” (17:51) Silver in consumer products, most recommended product in Amazon and its level of safety (20:19) Other potencies available and their level of safety (23:00) Wiping out good bacteria with Silver (23:54) Silver on preventing COVID (24:30) A quick recap and closing statement (24:51)   Resources from this episode: Colloidal Silver: The Exceptional Antibiotic Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria A Look Back at the Man Who Turned Blue Argyria: The life and adventures of a silver woman on planet earth, Rosemary Jabos Oral toxicity of silver ions, silver nanoparticles and colloidal silver--a review A case of generalized argyria presenting with muscle weakness Colloidal Silver Ingestion Associated with Leukocytoclastic Vasculitis in an Adolescent Female Brain involvement in generalized argyria 120 Years of Nanosilver History: Implications for Policy Makers Exposure-related health effects of silver and silver compounds: a review Fraudulent Coronavirus Disease 2019 (COVID-19) Products   What are your thoughts on using Silver in medical practices? Leave a review and rate this episode. Visit us and suggest topics using the #MedicalMyths: https://www.drchristianson.com/ Dr. Christianson on Facebook Dr. Christianson on Instagram

On this episode of the Burn Care Radio we review some of the most common complications that occur when caring for the burn patient. The podcast guest is Lindsay Desantis, the burn program manager at a Level-I trauma facility. We discuss the 5 most common complications and ways to prevent them from happening. All episodes offer continuing education credits (CE). To earn free EMS and nursing CE's go to our custom education website and create an account. Website: https://burncenters.cloud-cme.com/default.aspx*Addendum: Early mobilization is very important. Over fluid resuscitation can cause complications such as compartment syndrome and burn injury conversion (worsening of the initial injury) to name a few. Colloids play an important role in the initial fluid resuscitation phase.Disclaimer: The content, information, opinions, and viewpoints contained in these educational materials are those of the authors or contributors of such materials. While the BRCA Foundation, Inc. (“Foundation”) and its committees take great care to screen the credentials of the contributors and make every attempt to review the contents, the Foundation MAKES NO WARRANTY, EXPRESSED OR IMPLIED, as to the completeness or accuracy of the content contained in the educational materials or on this website or in any podcast. The reader of these materials and listener of the podcast uses these materials at his or her own risk, and the Foundation shall not be responsible for any errors, omissions, or inaccuracies in these materials, whether arising through negligence, oversight, or otherwise. Reliance on any information appearing on this site and/or this podcast is strictly at your own risk.The information and education material contained herein is meant to promote the general understanding and dialog of burn [trauma] topics by healthcare professionals. Such information is not meant or intended to serve as a substitute for clinical training, experience, or judgment. This information and material is provided for general educational purposes only and should not be considered the exclusive source for this type of information. This information and material is intended for healthcare professionals and not intended for patients or individuals. Copyright © 2020 BRCA Foundation, Inc. All rights reserved. No part of this publication may be reproduced without written permission. Please email foundation@burnfdn.org if you have any questions, need help or have suggestions for future education events.Thank you for all that you do! Be safe, The Burn and Reconstructive Centers of America (BRCA)

In the face of mounting criticism, Madagascar’s President Andry Rajoelina continues to champion COVID Organics, an herbal remedy produced by Malagasy Institute of Applied Research (IMRA) last month.Related: Coronavirus — and locusts — threaten Kenya’s food security“COVID Organics, needless to say, is a preventative and curative remedy against COVID-19. It works very well,” Rajoelina said during an interview with French media on Monday.The herbal drink, developed by local scientists, comes from traditional medicinal plants, including Artemisia arrua, which is native to China, the president said. “It’s a very popular herbal medicine. It’s one of the most frequently used herbs in parts of the world.”Chrisna Gouws, North-West University in South Africa“It’s a very popular herbal medicine. It’s one of the most frequently used herbs in parts of the world,” said professor Chrisna Gouws, a biochemist researching traditional medicine at North-West University in South Africa. “The scientific community became interested because it contains artemisinin, which is a recognized anti-malarial treatment.”Traditional medicine continues to be widely used across Africa. According to President Rajoelina, 80% of the population of Madagascar uses it.“It’s also very accessible and affordable,” especially for those living in rural areas with little access to health care systems, Gouws said.Related: Twitter and Facebook are collaborating to stop the spread of coronavirus misinformation. Is it enough?African traditional healers aren’t alone in looking to local herbs for treating illnesses.“There are quite a few prescribed Western medicines that have their source in African herbal remedies,” Gouws added, citing the chemotherapy drugs vinblastine and vincristine, which are derived from the Madagascar periwinkle plant.Madagascar isn’t the only one interested in exploring the potential use of Artemisia arrua in fighting the coronavirus. Last month, the German Max Planck Institute of Colloids and Interfaces announced its partnership with an American company to test the plant’s extracts and derivatives against COVID-19.Currently, however, there is no evidence that the plant is effective in preventing or treating the new coronavirus.“We would caution and advise against countries adopting a product which has not been taken through tests to see its efficacy against COVID-19.”Dr. Matshidiso Moeti, WHO Africa“We would caution and advise against countries adopting a product which has not been taken through tests to see its efficacy against COVID-19,” said the World Health Organization's Africa director, Dr. Matshidiso Moeti.  Related: Malaysia eradicated Nipah virus. Now it’s a leader in the battle against coronavirus.“Anything that is being used should be done under conditions of [a] clinical trial, where the evidence can be collected and it can be assured that it is not a risk to people’s health,” she continued.New medicines must be tested & be in line with ethical & scientific standards. We caution countries against adopting products that have not undergone rigorous clinical trials to ensure their safety & effectiveness against #COVID19. One fight. pic.twitter.com/WhthmPUCfy— Dr Matshidiso Moeti (@MoetiTshidi) May 8, 2020On Tuesday, WHO met with 70 African traditional medicine experts to discuss the role of traditional medicine during the pandemic.“They unanimously agreed that clinical trials must be conducted for all medicines in the region, without exception,” according to a WHO Africa post on Twitter.70 traditional medicine experts from countries across #Africa held a virtual meeting with @WHO on the role of traditional medicine in the #COVID19 response.They unanimously agreed that clinical trials must be conducted for all medicines in the Region, without exception. pic.twitter.com/fCKYiYiMqb— WHO African Region (@WHOAFRO) May 12, 2020“It’s widely seen that we have ignored these traditional treatments for a long time, possibly to our own detriment,” Gouws said.Still, she says African traditional medicine should undergo the same scientific process as anything created in a lab, especially because certain herb-drug interactions can be dangerous.“You need to know that it’s proven effective for the specific medical application; you must know it is proven safe for consumption, especially when there are underlying medical conditions,” Gouws said.Those concerns, however, haven’t slowed down Madagascar’s president, who has been donating COVID Organics to other African countries. As of Wednesday, Madagascar had reported 212 coronavirus cases and no deaths.“The vast majority of patients who were treated with this remedy are all the proof you need that it works,” said President Rajoelina, claiming that most patients who had received the herbal remedies improved within seven to 10 days.“No one has died in Madagascar. No one has died,” he continued.The African Union has reached out to Madagascar to review its technical data and information for COVID Organics.“This review will be based on global technical and ethical norms,” African Union said in a recent press release.

Crystalloids and colloids used in critically ill patients have different fluid composition. The composition may affect many things, including response to administration, clinical outcomes, and adverse effects. This talk with discuss the evidence behind the different types of fluids in critically ill patients, including a discussion of pros and cons of each fluid type.The session will be an interactive discussion led by investigators who have conducted randomized trials of different types of intravenous fluids.

Aparna Baskaran, Associate Professor of Physics at Brandeis University , studies the dynamics of soft materials far from equilibrium. She is presently focused on understanding active materials such as self-propelled colloids and in vitro cytoskeletal filament systems, field and shear driven colloids and granular materials.

In today's VETgirl online veterinary continuing education podcast, we review whether the use of gelatin colloids and hydroxyethyl starch (HES) result in renal tubular injury during shock.

In today's VETgirl online veterinary continuing education podcast, we review whether the use of gelatin colloids and hydroxyethyl starch (HES) result in renal tubular injury during shock.

Dr. Volodymyr Koman, a postdoc at Massachusetts Institute of Technology (MIT), discusses his work with cell-sized robots and explains their many possible uses in our ever-increasing technological world.   Dr. Koman received a BS in Applied Physics from the Ivan Franko National University of Lviv, then an MS in Photonics from Ghent University, before moving on to earn and complete his Ph.D. in Photonics at the prestigious Swiss Federal Institute of Technology Lausanne. Dr. Koman has a particular fascination with cell-sized robots and his work is focused in this area currently.   Dr. Koman discusses their cell-sized robots and how they arrived at the name of ‘colloidal nanoelectronic state machines' for their groundbreaking tiny robots. He describes state machines as simple robots with several states on board, essentially state machines that are doing computations on board of the particle. Dr. Koman describes his team's fascination with nature, which caused them to pose questions such as, can we think like nature? Their work takes the question into the test phase, as they seek to make advanced cell-size ‘state machines' or robots that can form tissues and create bigger structures.    These minuscule robots can sense their environment, store data, and complete computational tasks. They consist of tiny electronic circuits comprised of two-dimensional materials, riding along atop minuscule particles known as colloids. Dr. Koman explains how these tiny state machines can communicate with each other while completing tasks. He expounds upon their vision for the future of these infinitesimal robots.   Dr. Koman provides details on the structures and circuits of their tiny state machines, and how they hope to effectively allow them to transform and change shape. These machines will look very different from our current machines and from our cells, Dr. Koman states.    The cellular-size technology expert provides further information on uses within the bloodstream. One particular area of expansion for the technology could be for diagnostics. By combining these tiny objects with complex circuitry, it may open up possibilities for the creation of devices that could be utilized to carry out diagnostic journeys into the human digestive system. Colloids can exist in environments and move about in ways that other materials simply cannot, which makes them particularly attractive for specialized tasks. Dr. Koman talks about the future of robotics and his team's outlook for their advanced tiny robots. From bloodstream to tissue, the uses and possibilities are nearly limitless.

The battle over the superiority of resuscitation fluids is coming to a boil. Enter the Fluid Wars. Are Lactated Ringers superior to normal saline? Will LR increase a patient’s lactate? What about albumin? The Curbsiders quench the thirst for knowledge by turning to masters Dr. Pascale Khairallah (@Khairallah_P), Dr. Charlie Wray (@WrayCharles) and Dr. Joel Topf (@kidneyboy) for guidance in this special @NephMadness episode that will get your feet wet with the complicated world of fluid resuscitation. Fill out your bracket for NephMadness 2019 today and sign up as part of The Curbsiders! Full show notes available at https://thecurbsiders.com/episode-list. Join our mailing list and receive a PDF copy of our show notes every Monday. Credits Written and produced by: Justin Berk MD, Pascale Khairallah MD NephMadness Pun Contest produced by: Hannah R Abrams MS3 Hosts: Matthew Watto MD, Paul Williams MD, Stuart Brigham MD Edited by: Matthew Watto MD Guest:  Pascale Khairallah MD, Charlie Wray DO, Joel Topf MD Time Stamps 00:00 Nephmadness pun contest 02:18 Disclaimer 02:52 Intro to the show and NephMadness, guest bios 08:04 Guest one-liners, 10:58 Joel explains NephMadness 12:58  Guest book recommendations and career advice 17:30 Clinical case; goals of fluid resuscitation; choice of initial IV fluid Corporate (TV series) Comedy Central 19:41 Complications of normal saline 21:29 Colloids versus crystalloids LR versus normal saline is not an innocuous decision 26:32 Saline versus balance fluids. What’s the makeup? 28:19 Does lactated ringers elevate lactate? 31:03 Is hyperkalemia a contraindication for LR? 32:39 Lactated ringers versus plasma-lyte and cost of fluid 34:49 In vitro risks of normal saline 40:31 SMART and SALT-ED trial 46:08 Stuart finds the IV fluid price list 44:37 Each panelist weighs in on saline versus balanced fluids 46:45 Why do patients with metabolic alkalosis thrive on saline? 49:04 Outro

The care of critically ill patients is highly complex, requiring treatments for their underlying conditions and for the consequences of those conditions, such as the loss of bodily fluids. A wide range of these treatments are assessed in Cochrane Reviews and one of these was updated in August 2018, looking at the effects of giving patients extra fluids. Lead author, Sharon Lewis from the Royal Lancaster Infirmary in the UK, tells us about the latest findings in this podcast.

The care of critically ill patients is highly complex, requiring treatments for their underlying conditions and for the consequences of those conditions, such as the loss of bodily fluids. A wide range of these treatments are assessed in Cochrane Reviews and one of these was updated in August 2018, looking at the effects of giving patients extra fluids. Lead author, Sharon Lewis from the Royal Lancaster Infirmary in the UK, tells us about the latest findings in this podcast.

The care of critically ill patients is highly complex, requiring treatments for their underlying conditions and for the consequences of those conditions, such as the loss of bodily fluids. A wide range of these treatments are assessed in Cochrane Reviews and one of these was updated in August 2018, looking at the effects of giving patients extra fluids. Lead author, Sharon Lewis from the Royal Lancaster Infirmary in the UK, tells us about the latest findings in this podcast.

Dr. Ali Al-Sawalmih is the director of the Marine Science Station (MSS) Research Institute in Aqaba, Jordan and a researcher on Marine and Coastal Sciences at the University of Jordan in Aqaba since 2012. He has prior 5 years of experience in Germany on Marine Calcification at the Max Planck Institute of Colloids and Interfaces (MPIKG) in Germany. Dr. Al-Sawalmih earned the MSc degree in Physics at Stuttgart University / Max Planck Institute for Solid State Research (MPI FKF) in 2004, and PhD degree in marine materials at the RWTH Aachen University and Max Planck Institute for Iron Research (MPIE) in 2007.   “For one who wants to be a researcher first before becoming a director or a manager being organized can save time, can make your work perfect and it can make you avoid mistakes as much as possible.” Dr. Ali Al-Sawalmih

For a long time, Parkinson's disease was thought to be merely a disorder of the nervous system. But in the past decade researchers have started to look elsewhere in the body for clues to this debilitating disease—particularly in the gut. Host Meagan Cantwell talks with Viviane Labrie of the Van Andel Institute in Grand Rapids, Michigan, about new research suggesting people without their appendixes have a reduced risk of Parkinson's. Labrie also describes the possible mechanism behind this connection. And host Sarah Crespi talks with Peter Fratzl of the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, about what materials scientists can learn from nature. The natural world might not produce innovations like carbon nanotubes, but evolution has forged innumerable materials from very limited resources—mostly sugars, proteins, and minerals. Fratzl discusses how plants make time-release seedpods that are triggered by nothing but fire and rain, the amazing suckerin protein that comprises squid teeth, and how cicadas make their transparent, self-cleaning wings from simple building blocks. Fratzl's review is part of a special section in Science on composite materials. Read the whole package, including a review on using renewables like coconut fiber for building cars and incorporating carbon nanotubes and graphene into composites. This week's episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Roger Smith/Flickr; Music: Jeffrey Cook]

For a long time, Parkinson’s disease was thought to be merely a disorder of the nervous system. But in the past decade researchers have started to look elsewhere in the body for clues to this debilitating disease—particularly in the gut. Host Meagan Cantwell talks with Viviane Labrie of the Van Andel Institute in Grand Rapids, Michigan, about new research suggesting people without their appendixes have a reduced risk of Parkinson’s. Labrie also describes the possible mechanism behind this connection. And host Sarah Crespi talks with Peter Fratzl of the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, about what materials scientists can learn from nature. The natural world might not produce innovations like carbon nanotubes, but evolution has forged innumerable materials from very limited resources—mostly sugars, proteins, and minerals. Fratzl discusses how plants make time-release seedpods that are triggered by nothing but fire and rain, the amazing suckerin protein that comprises squid teeth, and how cicadas make their transparent, self-cleaning wings from simple building blocks. Fratzl’s review is part of a special section in Science on composite materials. Read the whole package, including a review on using renewables like coconut fiber for building cars and incorporating carbon nanotubes and graphene into composites. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Roger Smith/Flickr; Music: Jeffrey Cook]

Stefano Sacanna is Assistant Professor in the Department of Chemistry at New York University. We talk about colloidal materials, interdisciplinary research, and wearing GoPro cameras in lab. For more information: Micro-particles self-assemble into spinning gears video Colloids and Interface Symposium website Colloid Open Access Library Colloid synthesis tutorials

Knowledge Link through Art and Science (KLAS) is an Artist in Residence program of the Max Planck Society. KLAS fosters ArtSci exchange and transdisciplinary innovation and education whilst also establishing a link between Synthetic Biology research groups of two research institutions – Rijksuniversiteit Groningen [RuG] and two Max Planck Institutes [MPI]. In addition to awarding two Artist Residencies in 2017, KLAS will present a series of events and conversations around specific thematic topics. KLAS is funded by the Max Planck Society and the Schering Foundation and organized by Polyhedra. Tom Robinson, from the Max-Planck Institute of Colloids and Interfaces, and his group, aim to build membrane structures using lipid vesicles, which mimic biological cell organelles. The goal is to understand how enzyme-catalyzed metabolic processes occur within confined organelles; and eventually, construct a cell using artificial membranes in order to understand how a cell functions.

Kevin and Shelly are back with another teaching episode. The Wise Guys discuss colloids and Blood Product components in their "teaching" format where Kevin answers "I don't know", and "Magic!" a lot.

In this VETgirl podcast, Dr. Lisa Powell, DACVECC reviews a study out of Canada that reviews the effects of tetrastarch, a synthetic colloid fluid on hemodynamic and laboratory variables in both healthy dogs and dogs with systemic inflammation. The goal of this study was to evaluate the response of administering equal volumes of isotonic crystalloids (0.9% saline) and synthetic colloids (e.g., tetrastarch) on hemodynamic and laboratory variables in dogs. This study looked at two population of dogs: healthy dogs and dogs with systemic inflammation. This study also evaluated several parameters including heart rate (HR), blood pressure, PCV, total protein (TP), lactate, and colloid osmotic pressure (COP) measurements. So, what'd they find? Overall, the administration of colloids was associated with a larger improvement in HR, systolic blood pressure, and mean blood pressure. Dogs with systemic inflammation also had similar increases in systolic blood pressure and decreases in PCV, TP, and lactate after administration of either fluid. This study found what we already know: colloids make great resuscitation fluids as compared to crystalloids (of course, Dr. Powell and Dr. Lee are biased for colloids). But are there potential side effects of colloids? References: 1. Gauthier V, Holowaychuk MK, Bersenas AM, et al. Effect of synthetic colloid administration on hemodynamic and laboratory variables in healthy dogs and dogs with systemic inflammation. J Vet Emerg Crit Care 2014;24(3):251-258.

In this VETgirl podcast, Dr. Lisa Powell, DACVECC reviews a study out of Canada that reviews the effects of tetrastarch, a synthetic colloid fluid on hemodynamic and laboratory variables in both healthy dogs and dogs with systemic inflammation. The goal of this study was to evaluate the response of administering equal volumes of isotonic crystalloids (0.9% saline) and synthetic colloids (e.g., tetrastarch) on hemodynamic and laboratory variables in dogs. This study looked at two population of dogs: healthy dogs and dogs with systemic inflammation. This study also evaluated several parameters including heart rate (HR), blood pressure, PCV, total protein (TP), lactate, and colloid osmotic pressure (COP) measurements. So, what'd they find? Overall, the administration of colloids was associated with a larger improvement in HR, systolic blood pressure, and mean blood pressure. Dogs with systemic inflammation also had similar increases in systolic blood pressure and decreases in PCV, TP, and lactate after administration of either fluid. This study found what we already know: colloids make great resuscitation fluids as compared to crystalloids (of course, Dr. Powell and Dr. Lee are biased for colloids). But are there potential side effects of colloids? References: 1. Gauthier V, Holowaychuk MK, Bersenas AM, et al. Effect of synthetic colloid administration on hemodynamic and laboratory variables in healthy dogs and dogs with systemic inflammation. J Vet Emerg Crit Care 2014;24(3):251-258.

Crystalloids versus colloids for resuscitation is an age old debate! In this episode I present the following paper before going on to talk about the use of colloids in hypoproteinaemia. Click Here For Your FREE Copy of a Transcript of This Episode For online presentations and notes on Hypovolaemia and Shock and Parenteral Fluid Therapy visit my online training portal. Cazzolli D, Prittie J. The crystalloid-colloid debate: Consequences of resuscitation fluid selection in veterinary critical care. J Vet Emerg Crit Care 2015. Early View online 22 January. ABSTRACT Objective: To provide a comprehensive review of the current literature in human and veterinary medicine evaluating the impact of resuscitation fluid choice on patient outcome and adverse effects. Data Sources: Prospective and retrospective studies, experimental models, and review articles in both human and veterinary medicine retrieved via PubMed. Human Data Synthesis: A series of recent, large, randomized controlled trials in critically ill human patients comparing crystalloid versus colloid driven fluid resuscitation algorithms have demonstrated no outcome benefit with the use of natural or synthetic colloids. Synthetic colloidal solutions are associated with an increased incidence of adverse effects including acute kidney injury, need for renal replacement therapy, and coagulopathies. Further, colloidal solutions demonstrate a larger volume of distribution in the setting of critical illness than hypothesized. These findings have created controversy regarding colloid fluid resuscitation in critically ill patients and challenge current resuscitation strategies. A thorough review of the most influential human data is provided. Veterinary Data Synthesis: No veterinary clinical outcome data pertaining to fluid resuscitation choice currently exist. Veterinary data from experimental and small clinical trials evaluating the coagulopathic effects of hydroxyethyl starch solutions are described. Data pertaining to the use of natural colloids and albumin products in clinical veterinary patients are reviewed. In addition, data pertaining to the comparative intravascular volume expansion effectiveness of different fluid types in canine patients are reviewed. Conclusions: Clinical data from critically ill human patients have failed to demonstrate an outcome advantage associated with colloidal fluid resuscitation and indicate that hydroxyethyl starch solutions may be associated with significant adverse effects, including acute kidney injury, need for renal replacement therapy, coagulopathies, and pathologic tissue uptake. The ability to apply these findings to veterinary patients is unknown; however, similar pathophysiology may apply, and critical re-evaluation of resuscitation strategies is justified.

Research in critical care, Colloids and crystaloids, Quality

The use of colloids is more commonly utilized in veterinary medicine as a means of increasing colloid osmotic pressure (COP). Rarely, there are complications associated with the use of colloids, including volume overload and effects on coagulation (hypocoagulability). This veterinary podcast reviews the effects of the synthetic colloid hydroxyethyl starch 130/0.4 (Voluven) on coagulation and reiterates how clinical patients receiving synthetic colloids should be monitored for changes in their coagulation profiles and treated accordingly.

The use of colloids is more commonly utilized in veterinary medicine as a means of increasing colloid osmotic pressure (COP). Rarely, there are complications associated with the use of colloids, including volume overload and effects on coagulation (hypocoagulability). This veterinary podcast reviews the effects of the synthetic colloid hydroxyethyl starch 130/0.4 (Voluven) on coagulation and reiterates how clinical patients receiving synthetic colloids should be monitored for changes in their coagulation profiles and treated accordingly.

Editor's Audio Summary by Mary McGrae McDermott, MD, Senior Editor, the Journal of the American Medical Association, for the November 06, 2013 issue

Wed, 17 Jul 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/17334/ https://edoc.ub.uni-muenchen.de/17334/1/Drube_Fabian.pdf Drube, Fabian ddc:530, ddc:500, Fakultät für Physik

Smalyukh, I (University of Colorado) Tuesday 25 June 2013, 09:00-09:45

Sluckin, T (University of Southampton) Tuesday 23 April 2013, 15:00-16:00

Smalyukh, I (University of Colorado at Boulder) Tuesday 07 May 2013, 14:00-15:00

Lavrentovich, OD (Kent State University) Monday 07 January 2013, 11:30-12:30

This episode provide some basic description of colloids as will as some myths.  

Oleg Lavrentovich discusses the effects that an electric field can have on simple crystal particles within a complex medium.