Podcast appearances and mentions of John Cryan

Join Captain Michelle Huntington and Guy 'The Clown' Newman as they dive into the mind-blowing world of gut health and mental wellbeing. After discovering "The Psychobiotic Revolution" by Scott Anderson with Dr John Cryan and Dr Ted Dinan, Guy can't contain his excitement about the fascinating connections between what we eat and how we feel. Through hilarious personal stories about dairy disasters, gluten mishaps, and ice cream adventures, our hosts make the cutting-edge science of the gut-brain connection both entertaining and accessible. They explore how our trillions of gut bacteria influence everything from our moods to our memory, and why comfort eating might actually be our microbiota calling the shots. Whether you're curious about the science behind your food cravings or wondering why chocolate makes you feel better, this episode of Captain and the Clown serves up serious science with a side of laughter. The duo shares their own experiences with fasting, food intolerances, and the quest for mental clarity, while unpacking how this revolutionary research could change our approach to mental health.Enjoy!

Send us a textDr. Brandon Crawford and microbiome researcher Martha Carlin explore the intricate connections between gut health, the environment, and overall wellness. They discuss how the food we consume influences our microbiome, the impact of glyphosate on nutrient absorption, and the role of the microbiome in brain health. Martha shares her personal journey into microbiome research, highlighting the importance of critical thinking in healthcare. The conversation also touches on the significance of viruses, the vagus nerve, and the influence of light on microbiome health.In this conversation, Dr. Brandon Crawford and Martha Carlin explore the intricate relationship between light exposure, gut health, and innovative probiotic solutions. They discuss how light influences the microbiome and metabolic health, the importance of locally sourced foods, and the development of unique probiotic products aimed at restoring gut function and overall well-being. Practical steps for maintaining gut health and the significance of a positive mindset toward food are also emphasized.What You'll LearnGut health is shaped by the environment, locally sourced foods, and the balance of good and bad microbes in our microbiome.The microbiome plays a vital role in immune function, neurotransmitter production, and overall health.Food acts as information, influencing our genes, health, and adaptation to environmental and seasonal changes.Factors like glyphosate, light exposure, and vagus nerve stimulation can significantly impact gut and microbiome health.Viruses within our microbiome can be beneficial and contribute to a healthy ecosystem.Critical thinking is essential for understanding the complex connections between health, disease, and environmental factors.ResourcesMartha's Quest Blog: https://www.marthasquest.comBook: The Psychobiotic Revolution by Scott C. Anderson with John Cryan and Ted Dinan – A great primer on the microbiome's role in mental healthProducts 528 Innovations Lasers NeuroSolution Full Spectrum CBD NeuroSolution Broad Spectrum CBD NeuroSolution StimPod Learn MoreFor more information, resources, and podcast episodes, visit https://tinyurl.com/3ppwdfpm

Fri, 24 Jan 2025 00:00:00 +0000 https://seesee.podigee.io/s3e12-john-cryan f9d417dd4b9c1419db8383f62238f1f5 In this episode, we embark on a fascinating journey to explore one of the most groundbreaking areas of science - the gut-brain axis! Leading the way is none other than world-renowned neuroscientist Professor John Cryan of University College Cork, whose pioneering work has helped uncovered the powerful link between the gut microbiome and mental health and behaviour. Co-hosted by one of Europe's leading neurosurgeons, Peter Vajkoczy, this is one episode you won't want to miss. So, sit back and buckle up as we navigate the neural pathways that connect our gut to our brain, and discover how this connection plays a critical role in a wide range of conditions, from mental disorders to degenerative diseases. We'll delve into Professor Cryan's cutting-edge research, exploring the diseases his team in Cork are targeting and the innovative delivery systems they're developing to make genetic changes in the brain. You'll also hear about the forces that shape our microbiota throughout our lives, from the importance of vaginal birth and breast milk to the relationship between stress, dementia and depression, and the impact of diet on social behaviour, cognitive decline and aging, and mental health. We'll also explore the exciting new field of psychobiotics, which Cryan covers in his bestselling book, “The Psychobiotic Revolution: Mood, Food and the New Science of the Gut-Brain Connection”. Prepare to be amazed by the potential future treatments for neurological and mental health conditions through the lens of microbiota and neuroscience. Join us for an unforgettable episode as microbes and neurons bring us closer to understanding a shared universe of the gut and the brain! *Professor John F. Cryan is Vice-President for Research and Innovation at University College Cork (UCC), Professor in the Department of Anatomy and Neuroscience, and Principal Investigator at the APC Microbiome Ireland Institute. His pioneering research concentrates on the gut-brain axis and the impact of gut microbes on stress, psychiatric and immune disorders, as well as their influence on mental health. He is a leading figure in this field, with numerous influential publications and significant contributions to scientific research and public understanding of the microbiome. He has published over 600 peer-reviewed articles and has served as co-editor for several books. Additionally, he currently serves as Editor-in-Chief of Neuropharmacology and Neurobiology of Stress, and is a member of the editorial boards of 15 other scientific journals. **This episode is cohosted by Prof. Peter Vajcokzy. He has been Head of Neurosurgery at Charité-Universitätsmedizin in Berlin since 2007. He leads 5,000 brain surgeries a year, 800 of which he performs. He is a full professor at Charité and an associate professor at Heidelberg. He treats cerebrovascular disorders, brain tumours, skull base tumours and performs minimally invasive spine and peripheral surgery. He also performs functional neurosurgery and pain management procedures. His research focuses on brain cancer and the mechanisms of brain tumours. He also studies the monitoring of neocortically ill patients after vessel occlusion. https://publish.ucc.ie/researchprofiles/C003/jcryan Social Media: John F. Cryan (@jfcryan) · X https://scholar.google.com/citations?user=3SiQStcAAAAJ&hl=en https://www.amazon.com/Books-John-F-Cryan/s?rh=n%3A283155%2Cp_27%3AJohn+F.+Cryan TEDMED Food for thought: How gut microbes change your mind https://www.youtube.com/watch?v=kMVxbnfSP-Q Feed Your Microbes - Nurture Your Mind | John Cryan | TEDxHa'pennyBridge https://www.youtube.com/watch?v=vKxomLM7SVc NETFLIX Documentary: “Hack your Health” featuring Prof. John Cryan https://www.netflix.com/tudum/articles/hack-your-health-secrets-of-your-gut-release-date-trailer-news Grandmaternal stress and during pregnancy and DNA Germany/ Brazil and Sweden) (Paper published in 2017 Serpeloni F, Radtke K, de Assis SG, Henning F, Nätt D, Elbert T. Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study. Transl Psychiatry. 2017 Aug 15;7(8):e1202. doi: 10.1038/tp.2017.153. PMID: 28809857; PMCID: PMC5611722. https://pubmed.ncbi.nlm.nih.gov/28809857/ 3 12 full no Gut-brain axis,Gut Microbiome,Microbiome,Mental health,Neuroscience,Neurobiology,Gut-brain connection,Psychobiotics,Neurodegenerative diseases,Microbiota Dr. Cecilia Ponce Rivera

Marianne Heiss lädt zu einem exklusiven Gespräch mit Christian Sewing ein, wer nach seinem Abitur 1989 eine Ausbildung zum Bankkaufmann bei der Deutschen Bank in Bielefeld begonnen und im Anschluss ein berufsbegleitendes Studium der Betriebswirtschaftsl-ehre in Bielefeld und Hamburg absolviert hat. Von 1995 bis 2005 war Christian Sewing in Frankfurt, London, Singapur, Toronto und Tokio unterwegs. Von 2005 bis 2007 war er Mitglied des Vorstands der Deutschen Genossenschafts-Hypothenkbank, bevor er im April 2007, kurz vor der Finanz- und Wirtschaftskriste, zur Deutschen Bank zurückkehrte. Anfang 2015 wurde Christian Sewing in den Vorstand der Deutschen Bank für den Bereich Rechts-abteilung und Krisenstab, sowie Innenrevision berufen. Den Bereich Privat- und Firmenkundengeschäft hat Christian Sewing ab Juli 2015 übernommen und dabei die Digitalisierung vorangetrieben. Ab März 2017 war er stellvertredender Vorstandsvorsitzender und am 8. April 2018 hat Christian Sewing schließlich das Amt des Vorstandsvorsitzenden der Deutschen Bank von John Cryan übernommen. Seit Juli 2021 ist der Präsident des Deutschen Bankverbandes und seit März 2023 ist Christian Sewing zusätzlich Präsident des Europäischen Bankenverbandes. Christian Sewing ist bekennender Fan des FC Bayern München. Der Oper zieht Christian Sewing ein Coldplay Konzert vor. Seinen sportlichen Ehrgeiz übt er als passionierter Tennisspieler und beim Skifahren aus. ----- Möchtest du was bestimmtes hören? (00:00) – Begrüßung und Vorstellung von Christian Sewing, CEO Deutsche Bank AG (03:11) – Bedeutung & Herausforderungen von wirtschaftlichem Wachstum (05:05) – Vergleich von Arbeitszeiten und Produktivität international (07:03) – Rolle der Deutschen Bank in Deutschland und global (10:06) – Bürokratie und Überregulierung in Europa (13:29) – Kapitalmarktunion als Lösung für Wachstum (15:53) – Bedeutung von Europa als gemeinsamer Markt (18:08) – Lektionen aus der US-amerikanischen Verteidigungspolitik (19:59) – Einfluss von Handelszöllen auf die deutsche Wirtschaft (22:09) – Basel III und Deregulierung im Bankensektor (25:24) – Markenstärke und Zukunftsziele der Deutschen Bank (28:30) – Führungskultur und Transformation der Bank (30:32) – Rolle der Mitarbeiter und Werte im Unternehmen (32:55) – Persönliche Werte und Resilienz von Christian Sewing (35:05) – Rückblick: Entscheidungen und Lerneffekte (38:20) – Krisenmanagement und Lehren aus der Griechenland-Rettung (41:13) – Generationenunterschiede und Gelassenheit (43:32) – Wünsche für die Zukunft Europas und Deutschlands (44:42) – Abschluss und Optimismus für Europa ----- Willst du diese Folge nicht nur anhören, sondern Christian Sewing auch per Video sehen? Dann besuche gerne unserem YouTube Kanal: ⁠https://www.youtube.com/@followvoices⁠ ----- Folge VOICES auf Socials... ▸ www – ⁠voices.fm⁠ ▸ Instagram – ⁠@followvoices⁠ ▸ YouTube – ⁠@followvoices⁠ ▸ LinkedIn – ⁠@marianne-heiß

We hear about fiber as the main ingredient for a good poo. But we're starting to hear that it's much more than that! Fiber is being hailed as a powerhouse nutrient, from powering up your gut and boosting your mental health to even helping with weight loss. So, does fiber really live up to the hype? We dive into the science with microbiologist Dr. Deirdre Mikkelsen, neuroscientist Prof. John Cryan, and nutrition scientist Dr. Andrea Glenn.  Find our transcript here: https://bit.ly/ScienceVsFiber In this episode, we cover: (00:00) Fiber is so hot right now (02:16) How fiber helps you poo (04:55) Fiber supercharges the gut  (14:02) Can fiber help your mental health?  (18:36) A goop for a healthy heart  (24:52) Fiber and weight loss  This episode was produced by Michelle Dang, with help from Wendy Zukerman, Meryl Horn, Rose Rimler, and Ekedi Fauster-Keeys. We're edited by Blythe Terrell. Fact checking by Erica Akiko Howard. Mix and sound design by Sam Bair. Music written by Bobby Lord, Emma Munger, Peter Leonard and Bumi Hidaka. Recording help from Nick Kilvert. Extra thanks to Kafayat Yusuf. And thanks to Joseph Lavelle Wilson and the Zukerman family. Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

After being interrupted by the pandemic, Save the Pine Bush will hold an in-person vegetarian lasagna dinner on Wednesday, September 25 at 6:00 at St. Andrew's Episcopal Church, 10 N. Main, Albany. Save the Pine Bush has held monthly dinners since 1980. John Cryan, Co-founder of the Long Island Pine Barrens Society, will speak about “Saving the Pine Bush All Over Again.” Lynne Jackson talks with Mark Dunlea of Hudson Mohawk Magazine about Save the Pine Bush's current activities, including two development projects it is opposing in Guilderland and Colone as well as county funding for land preservation

“A few years ago, I might have chuckled at the naiveté of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the foreseeable future.”—Coleen MurphyTranscript with external linksEric Topol (00:06):Hello, this is Eric Topol from Ground Truths, and I'm just so delighted to have with me Professor Coleen Murphy, who has written this exceptional book, How We Age: The Science of Longevity. It is a phenomenal book and I'm very eager to discuss it with you, Coleen.Coleen Murphy (00:25):Thanks for having me on.Eric Topol (00:27):Oh yeah. Well, just so everyone who doesn't know Professor Murphy, she's at Princeton. She's the Richard Fisher Preceptor in Integrative Genomics, the Lewis-Sigler Institute for Integrative Genomics at Princeton, and director of the Paul Glenn Laboratories for Aging Research. Well, obviously you've been in this field for decades now, even though you're still very young. The classic paper that I can go back to would be in Nature 2003 with the DAF-16 and doubling the lifespan of C. elegans or better known as a roundworm. Would that be the first major entry you had?Coleen Murphy (01:17):Yeah, that was my postdoctoral work with Cynthia Kenyon.Eric Topol (01:20):Right, and you haven't stopped since you've been on a tear and you've put together a book which has a hundred pages of references in a small font. I don't know what the total number is, but it must be a thousand or something.Coleen Murphy (01:35):Actually, it's just under a thousand. That's right.Eric Topol (01:37):That's a good guess.Coleen Murphy (01:38):Good guess. Yeah.Eric Topol (01:39):So, because I too have a great interest in this area, I found just the resource that you've put together as extraordinary in terms of the science and all the work you've put together. What I was hoping to do today is to kind of take us through some of the real exciting pathways because there's a sentence in your book, which I thought was really kind of nailed it, and it actually is aligned with my sense. Obviously don't have the expertise by any means that you do here but it says, “A few years ago, I might have chuckled at the naivety of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the foreseeable future.” That's a pretty strong statement for a person who's deep into the science. First I thought we'd explore healthy aging health span versus lifespan. Can you differentiate that as to your expectations?Coleen Murphy (02:54):So, I think most people would agree that they don't want to live necessary super long. What they really want to do is live a healthy life as long as they can. I think that a lot of people also have this fear that when we talk about extending lifespan, that we're ignoring that part. And I do want to assure everyone that the people in the researchers in the aging field are very much aware of this issue and have, especially in the past decade, I think put a real emphasis on this idea of quality of life and health span. What's reassuring is actually that many of the mechanisms that extend lifespan in all these model organisms also extend health span as well and so I don't think we're going to, they're not diametrically opposed, like we'll get to a healthier quality of life, I think in these efforts to extend lifespan as well.Eric Topol (03:50):Yeah, I think that's important that you're bringing that up, which is there's this overlap, like a Venn diagram where things that do help with longevity should help with health span, and we don't necessarily have to follow as you call them the immoralists, as far as living to 190 or whatever year. Now, one of the pathways that's been of course a big one for years and studied in multiple species has been caloric restriction. I wonder if you could talk to that and obviously there's now mimetics that could simulate that so you wouldn't have to go through some major dietary starvation, if you will. What are your thoughts on that pathway?Coleen Murphy (04:41):Yeah, actually I'm really glad you brought up mimetics because often the conversation starts and ends with you should eat less. I think that is a really hard thing for a lot of people to do. So just for the background, so dietary restriction or caloric restriction, the idea is that you would have to take in up to 30% less than your normal intake in order to start seeing results. When we've done this with laboratory animals of all kinds, this works from yeast all the way up through mice, actually primates, in fact, it does extend lifespan and in most metrics of health span the quality of life, it does improve that as well. On the other hand, I think psychologically it's really tough to not eat enough and I think that's a part that we kind of blindly ignore when we talk about this pathway.Coleen Murphy (05:30):And of course, if we gave any of those animals the choice of whether they want to start eating more, they would. So, it's like that's not the experiment we ever hear about. And so, the idea for studying this pathway isn't just to say, okay, this works and now we know how it works, but as you pointed out, mimetics, so can we target the molecules in the pathway so that we can help people achieve the benefits of caloric restriction without necessarily having to do the kind of awful part of restriction? I think that's really cool, and especially it might be very good for people who are undergoing certain, have certain diseases or have certain impairments that it might make it difficult ever to do dietary restrictions, so I think that's a really great thing that the field is kind of getting towards now.Eric Topol (06:15):And I think in fact, just today, it's every day there's something published now. Just today there was a University of Southern California study, a randomized study report comparing plant-based fasting-mimicking diet versus controlled diet, and showed that many metabolic features were improved quite substantially and projected that if you stayed on that diet, you'd gain two and a half years of healthy aging or that you would have, that's a bit of an extrapolation, but quite a bit of benefit. Now, what candidates would simulate caloric restriction? I mean, what kind of molecules would help us do that? And by the way, in the book you mentioned that the price to pay is that the brain slows down with caloric restrictions.Coleen Murphy (07:10):There's at least one study that shows that.Coleen Murphy (07:13):Yeah, so it's good to keep in mind. One of the big things that is being looked at as rapamycin, looking at that TOR pathway. So that's being explored as one of these really good mimetics. And of course, you have things that are analogs of that, so rapalogs, and so people are trying to develop drugs that mimic that, do the same kind of thing without probably some of the side effects that you might see with rapamycin. Metformin is another one, although it's interesting when you talk to people about metformin who work on it, it's argued about what is exactly the target of metformin. There's thought maybe also acts in the TOR pathway could affect complex one of mitochondria. Some of the things we know that they work, and we don't necessarily know how they work. And then of course there's new drugs all the time where people are trying to develop to other target, other molecules. So, we'll see, but I think that the idea of mimetics is actually really good, and that part of the field is moving forward pretty quickly. This diet that you did just mention, it is really encouraging that they don't have to take a drug if you don't want to. If you eat the right kind of diet, it could be very beneficial.Eric Topol (08:20):Yeah, no, it was interesting. I was looking at the methods in that USC paper and they sent them a box of stuff that they would eat for three cycles, multiple weeks per cycle. It was a very interesting report, we'll link to that. Before we leave the caloric restriction and these mTOR pathway, you noted in the book that there some ongoing trials like PEARL, I looked that up and they finished the trial, but they haven't reported it and it's not that large. And then there's the FAME trial with metformin. I guess we'll get a readout on these trials in the not-too-distant future. Right?Coleen Murphy (08:57):Yeah, that's the hope that especially with the Metformin trial, which I think is going to be really large the FAME trial, that just to give the listeners a little background, one of the efforts in the field is not just to show that something works, but also to convince the FDA that aging could be a pharmaceutical, a disease that we might want to have interventions for. And to do that, we need to figure out the right way to do it. We can't do 30-year studies of safety and things to make sure that something's good, but maybe there are reasonable biomarkers that would tell us whether people are going to live a long time. And so, if we can use some of those things or targeting age-related diseases where we can get a faster readout as well. Those are reasonable things that companies could do that would help us to really confirm or maybe rule out some of these pharmaceuticals as effective interventions. I think that would be really great for consumers to know, is this thing really going to do good or not? And we just don't have that right now in the field. We have a lot of people saying something will work and it might and the studies in the lab, but when we get to humans, we really need more clinical studies to really tell us that things are going to be effective.Eric Topol (10:12):Right, I'm going to get to that in a bit too because I think you're bringing up a critical topic since there's an explosion of biopharma companies in this space, billions of dollars that have been put up for in capital and the question is what's going to be the ground rules to get these potential candidate drugs to final commercial approval. But before I leave, caloric restriction and insulin signaling and the homolog and the human to what your discovery of DAF-16, FOXO and all this, I just want you to comment, it wasn't necessarily developed in the book, but as you know, the GLP-1 drugs have become just the biggest drug class in medical history, and they do have some effects here that are very interesting. They are being tested as in Alzheimer's disease. Do you see that this is a candidate too that might promote healthy aging?Coleen Murphy (11:12):Yeah, I'm so glad you brought that up because my book, I finished writing it right before all this stuff came out, and it's looking really very compelling. People are on these drugs, they lose a ton of weight, but their blood biomarkers really become very good and on top of just the changes in weight and those kinds of effects. Let me just say, I think the biggest thing, the biggest risk actually for aging people right now are cardiovascular problems, cardiovascular disease, and these drugs, no doubt, it's going to basically make a huge dent in that. I'm absolutely sure of that. What I also find really interesting with those drugs is that the users report that they have fewer cravings for other things. So, this is not being looked at to treat alcoholism and drug addiction, other things, so it really opens up a whole new world of things that are bad for us that maybe we could avoid this with these peptides. It's almost staggering. I really think this going to be a huge, and as far as an aging drug, if you reduce your weight, you improve all your cardiovascular function, you don't feel like drinking all the time, all these things might be really great and I do think that people will live longer.Eric Topol (12:32):Yeah, no, it does have that look and you just have to wonder if as these will go on to oral drugs with triple receptors and very potent, maybe even avoiding peptides in the future too, that this could wind up being something that's exceedingly common to take for reasons far removed from the initial indication of type two diabetes and more recently of course, obesity. Now the next topic I wanted to get into with you were senolytics, these agents that basically are thought to reverse aging or slow aging. And again, since everything's coming out in a daily basis, there was a trial in diabetes macular edema where giving senolytic after people had failed their usual VEGF treatment was highly successful. So, we're starting to see, at least in the eye results. I wonder if you could describe how you conceive this field of senolytics?Coleen Murphy (13:41):Actually, I think they've made great progress in the past couple of years because there were some initial failures, like some of the things for osteoarthritis that went through I think phase two, but I think that one of the great things about the longevity biotech field is that they're starting to identify not just longevity, these age-related disorders that they could actually use. And so, it's kind of doubly beneficial. It tells us that the drugs actually do something and so maybe it'll be used for something else in the future and you get through, you can test safety, but also helping people actually have a very real problem that's acute that they really need to take care of. And so that's really exciting. Then in addition to the example you just mentioned, I was at a conference last summer where it was being explored whether some of these senolytics could be helpful for middle aged survivors of childhood cancers who do show various health effects from having gone through chemotherapies at a young age. So that's really exciting. Could you help people who are not aging, but they actually are showing having problems that we kind of associate with aging. And senolytics were at least the first thing I'd heard about that are actually being used for that, so there may be other approaches that help as well, but I think that's really great.Eric Topol (15:05):Well, and just to be clear the senolytics, I guess could be categorized at least one function might be to help clear dead cells. These senescent cells are bad actors and either they're taken out or they're somehow neutralized in their impact of secreting evil humors, if you will. Are there other forms of senolytics besides that way of dealing with these senescent cells?Coleen Murphy (15:33):I know that some people are exploring senomorphs, so things that make those cells just arrest but I do want to mention, of course, we lost a great Judith Campisi recently, and she was the one who discovered and described the senescent associated secretory phenotype, and she did amazing work in that field really opening that up. So, this idea that bad cells aren't just bad because they don't function, but they're actually toxic to other cells.Coleen Murphy (16:04):That's important for listeners to know. Yeah, so I don't know. I think that one of the things I'm excited about in the aging field is that it doesn't seem like there's one magic bullet. A lot of researchers will spend their time working on that one thing so if you only talk to that one person, you might get that impression, but there's a whole host of things that for bad or good, that things go wrong when we age, but those all end up being maybe targets that could help us live longer or at least in a healthier way. And so, we've already talked about a couple of them, but readers will see as we learn more, there might be more ways to help cells survive or to help us replace ourselves, for example.Eric Topol (16:45):I mean, I think what you're bringing up here is central because there's all these different, as I can see it, shots on goal that of course could be even used as combinations, no less senolytic interventions so we're getting closer as we started this conversation to fulfilling what you, I think is in store in the years ahead, which is extraordinary. Along with the senolytics, I wonder if you could just talk a little bit about these autophagy enhancers as a class of agents, maybe first explaining autophagy and then is this a realistic goal that we should be taking autophagy enhancers, or is this something that's too generalized that might have onward mTOR effects?Coleen Murphy (17:39):Well, it's interesting. Autophagy, so just for the listeners, autophagy literally means self-eating. So this is a pathway whereby proteins basically get degraded within the cell and those parts get recycled. And the idea is that if you have a cell or protein that's damaged in some way, or it can be renewed if you induce autophagy. I think I could be wrong here, but my sense is that the cancer field is really excited about autophagy enhancers. And so, I think that's probably where we'll see the biggest breakthroughs but along the way, of course we'll know because we'll know if they're safe and if there's other off-target effects. I think that that's largely being driven by the cancer field and the longevity field is kind of a little bit behind that, so we'll learn from them. It seems like a really exciting approach as well.Eric Topol (18:34):Yeah, it does. And then as you know, the idea of giving young blood, young plasma, which there already are places that do this, that it can help people who are cognitively impaired and have basically immediate effects, and sometimes at least with some durability. It's very anecdotal, but this idea, we don't know what's in the young blood or young plasma to some extent. How do you process that?Coleen Murphy (19:10):Okay. Well, so what we do know, and this is really work that a lot of people like Saul Villeda and Tony Wyss-Coray have done where they really have, they've taken that blood or plasma and then found the parts in the plasma that actually do specific jobs. And so, we actually are starting to learn a lot about that and that's exciting because of course, we don't really want to give people young blood. What we really would like to do is find out is there a particular factor in the blood? And there seems to be many that could be beneficial. And so, we really are getting close. We as a field, and specifically like the research I just mentioned and that's exciting because you can imagine, for example, if there's one factor that's in blood, that's in young blood, that's very helpful, manufacturing, a lot of that particular thing.Coleen Murphy (20:01):The other exciting thing, again, this is Saul Villeda's lab that found that exercise mice. So even if they're the same age mice, if one of them is exercised, it makes factors that actually from the liver of the mouse upon exercise, that then gets secreted and then affect, improve cognitive function as well. So it seems like even within the blood, there's multiple different ways to get blood factors that are beneficial, whether they're from young blood or from exercise blood. And so, there's a lot of things we don't yet know, but I do think that field is moving very fast and they're identifying a lot of things. In fact, so I'm the director of Simons Collaboration Plasticity in the Aging Brain, and on that website we're developing basically a page that can tell you what are the factors and what has it been shown to be associated with, because we're very interested in slowing normal cognitive aging and blood factors seem to be one of the really powerful ways that might be available to us very soon to be able to improve that.Eric Topol (21:03):Yeah, no, I'm glad you mentioned that, Coleen. I think the point that you made regarding exercise, I certainly was struck by that because in the book, because we've known about this association with exercise and cognition, and this I think is certainly one potential link. An area that is also fascinating is epigenetics, so a colleague of mine here in the Mesa, Juan Carlos Belmonte, who was at Salk and left to go to Altos, one of these many companies that are trying to change the world in health span and lifespan. Anyway, he had published back several years ago.Coleen Murphy (21:53):Yeah, 2016.Eric Topol (21:54):Yeah, CRISPR basically modulation of the epigenome through editing and showed a number of through specific pathways, a number of pretty remarkable effects. I wonder if you could comment about epigenetics, and then I also want to get into this fascinating topic of transgenerational inheritance, which may be tied of course to that. So, what about this pathway? Is there something to it?Coleen Murphy (22:29):Well, absolutely. I just think we need to learn a lot more about it. So just for the listener, so epigenetics, we think about genetics that's basically based on DNA and chromosomes. And so, when we think about epigenetics, that could be either, we could be talking about modulation of the histone marks on the chromosomes that allow the genes to be expressed or be silenced. And then on the DNA itself, there are methylation marks. And so, people have used, of course, Steve developed a, sorry, I'm sorry. Steve Horvath developed a very nice, he was first to develop a DNA methylation clock. So this idea that you could, and that was really interesting because he based it on, he used this machine learning method to narrow down to the 353 marks that were actually predictive or correlated with age, but we don't understand how it biologically what that manifests in. I think that's not well understood. At the chromatin level, there's a lot of work on the specific histone marks that may change, for example, how genes are transcribed and so understanding that better will maybe help us understand what those changes. There's things called epigenetic drift, so genes stop being carefully regulated with age, and then how can we make that maintain better with age? It's one of the goals of the field in addition to basically understanding what's going on at the epigenetic level.Eric Topol (24:01):So now of course, could we alter that? Oh, it is fascinating as you say, that you could have the Horvath clock to so accurately predict a person's biological age. And by the way, just a few days ago, there was a review by all these clock aging folks in nature medicine about the lack of standards. There's so many clocks to basically determine biological age versus chronological age. Before we get into the transgenerational inheritance, what is your sense? Obviously, these are getting marketed now, and this field is got ahead of its skis, if you will, but what about these biologic age markers?Coleen Murphy (25:02):Yeah, I'm glad to hear that. I haven't seen that review. I should look it up. It's good to know that the players in the field are addressing those points. So just for the listeners, so these DNA methylation clocks so when Steve Horvath developed the first one, it was based on the controls from a very large number of cancer controls for other reasons, so he used a huge amount of information. It really depended on the, he was trying to develop a clock that was independent of which tissue, but it turned out there's more and more clocks that are tissue specific and really organism specific, species specific. It really depends on what you're looking at to make these, and whether you're looking at chronological age or trying to predict biological age. I think it's a little frustrating because what you'd really like to know as a consumer, if you send off for one of these clock kits, is it right?Coleen Murphy (25:57):What's the margin of error? If I took it every week, would I get the same number? And so, I think my sense is that people take it until they get a low number then, but you'd really like to know if they work, because if you want to take it, do a control and they start, get your clock number and then start taking some intervention and ask whether it works, right? Yeah. So, I think because the players in the field recognize these issues, they're going to straighten it out, but I think one part that drives a little bit of the problem is that we don't understand what that DNA methylation mark change translates into biologically. If we understood that better, I think we'd have a better feeling about it. Anne Brunet and Tony Wyss-Coray maybe a year and a half ago, they had a nice paper where two years ago where they looked at, they use a different type of clock, a transcriptional clock, and that worked really well. So they were looking at transcriptional clock in the subventricular zone, and they were able to actually see changes not just with age, but also when there was an intervention. I can't remember if they look at dietary restriction and then maybe an exercise in the mice. And so that's important for us to know how well those clocks work.Coleen Murphy (27:13):I think it'll get there. It'll get there.Eric Topol (27:15):You don't want to pay a few hundred dollars and then be told that you're 10 years older biologically than your chronologic age, especially if it's wrong. Right?Coleen Murphy (27:25):Yes. It'll get there. I think it may not be quite there yet.Eric Topol (27:30):And by the way, while we're on that, the organ clocks paper, in fact, just a recent weeks, I did interview Tony Wyss-Coray from Stanford, and we talked about what I consider really a seminal paper because using plasma proteins, they're able to basically clock each organ. And that seems like a promising approach, which could also help prove the case that you're changing something favorably with one of these various intervention classes or categories. Do you think that's true?Coleen Murphy (28:05):That feels more real directly looking at the proteins then.Eric Topol (28:08):Yeah, exactly. I thought that was really exciting work, and I'm actually going to visit with Tony in a few weeks to discuss it further. So excited about it.Coleen Murphy (28:18):That's great. He's doing great work, so it'll be a fascinating conversation.Eric Topol (28:21):Yeah, well this is also fascinating. Now, transgenerational inheritance is a very controversial topic in humans, which it is not so much in every other species. Can you explain why that is?Coleen Murphy (28:38):Well, there's a lot of, I would say emotional baggage attached here, right? Because that's what people are talking about, like transgenerational trauma. There's no doubt that traumatic experiences in childhood actually do seem to change the genome and change have very real biological effects. And that's been shown. So that's within the first generation. It's also no doubt that in other organisms, like in plants like DNA methylation, that's exactly how they regulate things, and that's multiple generations. So that's kind of the norm. And so, the question for humans is whether something like this, like a traumatic experience or starvation or thing, has an effect, not just on the person who's experiencing it, but also on their progeny, even on their grand progeny. And so, it's tough, right? Because the data that are out there are from pretty terrible experiences like the Dutch hunger winter. And so, there's a limited set of data, and some of those data look good, and some of them look weaker. Yeah, I think that we still need to figure out what's going on there, and if it's real, it'd be interesting to know. Are there ways, for example, with these epigenetic modulators, are there ways that you could help people be healthier by erasing some of those marks of trauma, generational trauma?Eric Topol (30:03):Yeah. So, I mean, the theory as you're getting to would be you could change the epigenome, whether it's through chromatin, acetylation, methylation, somehow through these experiences and it would be going through down through multiple generations. The reason I know it's controversial is when I reviewed Sid Mukherjee's book, the Gene, he had put in that it was real in humans, and the attack dogs came out all over the place. Now, we've covered a lot of these pathways. One that we haven't yet touched on is the gut microbiome, and the idea here, of course, it could be somewhat linked to the caloric restriction story, but it seems to be independent of that as well. That is there, our immunity is very much influenced by our gut microbiome. There's the gut brain axis and all sorts of interactions going on there, but what about the idea of using probiotics and particular bacterial species as a introducing the people as an idea in the future to promote health span?Coleen Murphy (31:18):Yeah, it's a great idea. So, I just want to back up and say the microbiome, the reason it's so fraught is because for a long time, people had confused correlation and causation. So, they would see that a person who has X disease has a difference in the microbiome from people who don't have that disease. And so, the question was always, do they have that disease because of a difference in the microbiome or the disease influence in the microbiome? And of course, even things that's eating different food. For example, if a child with autism doesn't want to eat certain range of food, it's going to have an effect on the microbiome. That does not mean the microbiome cause their autism. And so that's something where, and the same thing with Alzheimer's disease patients. I think that's often the source of some of this confusion. I think people wish that they could cure a lot of diseases by taking a probiotic.Coleen Murphy (32:09):On the other hand, now there's actually some really compelling data. Dario Valenzano's lab did a really nice experiment in killifish, which is my second favorite aging model research organism. So killifish, turquoise killifish, only live a few months. And so, you can do aging studies really quickly and what Dario's group did was they took the microbiome at middle aged fish, they wiped out their microbiome with antibiotics, and they added back either young or same age, and they saw a really nice extension of lifespan with the young microbiome. So that suggests, in that case where everything else is the same, it really does have a nice effect. John Cryan's group in Ireland did something similar with mice, and they showed that there was a beneficial effect on cognitive function in older mice. So those are two examples of studies where it really does seem like there is an effect, so it could be beneficial. And then there's of course things like microbiome transfer for people who are in the hospital who have had other things, because your microbiome also helps you prevent other diseases. Those being there, if you wipe out all of your microbiome, you can actually get infected with other things. It's actually a protective barrier. There's a lot of benefits, I think in order to, we don't know a ton about how to control it. We know there are these, it's gross, but fecal microbiome transplantation.Eric Topol (33:42):FMT. Yeah, yeah.Coleen Murphy (33:44):Exactly. And so, I think that is kind of the extreme, but it can be done. I think in appropriate cases it could be a very good strategy.Eric Topol (33:53):It's interesting. There was a study about resilience of the immune system, which showed that women have a significant advantage in that they have just the right balance of not having a hyper inflammatory reaction to whether it's a pathogen or other stimulus. And they also have, of course, an immunocompetent system to respond, so unlike men overall, that although the problem of course with more prone to autoimmunity because of having two x chromosomes and exist or whatever other factors. But also, there's a balance that there's an advantage, in the immune system as a target for health span and lifespan, a lot of things that we've talked about have some interaction with the immune system. Is there anything direct that we can do to promote a healthier immune system and avoid immunosenescence and inflammaging or immuno aging or whatever you want to call it?Coleen Murphy (35:04):Sure, I will admit that immunology is a field that I want to learn more about, but I do not know enough about it to give a really great answer. I think it's one of the things I kind of shied away from when I wrote the book that if I were to rewrite it, I would add a whole new section on it. I think that's a really booming field, this interaction between immunology and aging. Obviously, there's immune aging, but what does that really mean?Coleen Murphy (35:28):I feel like I can't give you a really intelligent answer about that. Even though I'd like to, and I don't know how much of it's because there's just sort of this general idea that the immune system stops functioning well, but I do feel like the immune system is actually so mysterious. I have a peanut allergy, for example. We don't even really, I mean, we can prime ourselves against that now. We can give kids little bits of peanuts, but all the things that I feel like immunology is the one that's probably taking off the most, and we'll probably in a decade know way more about it than we do now, but I can't give you a very smart answer right now.Eric Topol (36:09):Yeah, no, I do think it's really provocative and the fact that if you have these exhausting T cells that are basically your backup system of your immune system, if they're not working, that's not good. And maybe they can be revved up without being problematic. We'll see.Coleen Murphy (36:27):And I guess the real question is do we need to do something independent or is that folded into everything else? If you were giving someone a drug that seemed very good systemically or some of these blood factors, would you have to do something special just for the immune system or is that something that would also be effective? I feel like that would be good to know.Eric Topol (36:44):Now the other area that I want to bring up, which is a little more futuristic is genome editing. So recently when I spoke to David Liu, he mentioned, well, actually it was Jennifer Doudna who first put it out there, but we discussed the idea of changing the people like me who are APOE4 carriers to APOE2, which is associated with longer life and all these other good things. Why don't we just edit ourselves to do that? Is that a prospect that you think ever could be actualized?Coleen Murphy (37:20):Well, I was just at a talk by Britt Adamson just moments ago, and that field is moving really fast, right? All the work that David Liu has done, and it's really exciting, this idea that you can now cure sickle cell anemia.Coleen Murphy (37:35):Fascinating. And I think Jennifer Doudna rightly proposed early on that what we should really be hitting first are like blood. Blood's really good because it's not hitting the germline. It's really something where we can help people at that stage. I was thinking about that while Britt was talking, what are the things we'd really want to address with CRISPR? I'm not sure how high up in the list aging related factors would be compared to a lot of childhood diseases, things that are really debilitating, but certainly is true since when we're looking at APOE4. I think that's the one exception because that is so strongly correlated with healthy lifespan and Alzheimer's and things, so we really want to do something about that. The question is how would we do that? That's not a blood factor. I think we'd have to think hard about that, but it is on the list of looming on the horizon.Eric Topol (38:35):I wouldn't be surprised if someday, and David, of course thought it's realistic, but it's not, obviously in the short term. Well, this has been enthralling to go through all these possibilities. I guess when you put it all together, there's just so many ways that we might be able to, and one of the things that you also pointed out in your book, which something that should not be forgotten, is the fact that all these things could even worsen the inequities that we face today. That is you have any one of these click, if not multiple, it isn't like they're going to be available to all. And the problem we have now, especially in this country without universal health and access issues, could be markedly exacerbated as we're seeing with the GLP-1 drugs too, by the way.Coleen Murphy (39:27):Absolutely.Eric Topol (39:28):So, I just want to give you a chance to reinforce what you wrote in the book, because I think this is where a lot of times science leads and doesn't realize the practical implications of who would benefit.Coleen Murphy (39:42):Yeah, I think actually for aging research often, even when I first started doing this work back in 2000, the first thing people would ask me if they're below a certain age was, don't you think that's terrible? Make the rich people just live the longest? And they're not wrong about that. I think what it can, we should raise awareness about the fact that even these things that we consider simple, like doing caloric restriction or getting exercise, even those things are not that straightforward if you're working two jobs or if you don't have access to excellent foods in your neighborhood, right? Fruits and vegetables. If we really want to not just extend longevity but raise life expectancy, then we should be doing a lot more that's for improving the quality of life of many people. And so there is that idea. On the other hand, I do want to point out that as we discover more and more of these things, like metformin is off patent, it's like it's really old. And so, it's more of these things get discovered and more broadly used. I do think that that may be a case where we could end up having more people might have access to things more easily. So that's my hope.Coleen Murphy (40:57):I don't want to discourage anyone from developing a longevity dry. I think eventually that could help a lot of people if it's not too absurdly expensive.Eric Topol (41:04):Yeah, no, I certainly agree. And one last footnote is that we did a study called The Wellderly here, about 1,400 people over age 85 who'd never been sick, so our goal here wasn't lifespan. It was to understand if there was genomics, which we did whole genome sequencing of this group. We didn't find much like the study that you cited in the book by the Calico group. And so just to give hope that people, if they don't have what they think are family genetics of short life or short health span, that may not be as much to that as a lot of people think. Any final thoughts about that point? Because it's one that's out there and data goes in different directions.Coleen Murphy (41:55):Yeah. The Calico study you mentioned, I think that's the one where they found that your health or lifespan mostly went with almost like your in-laws, which actually points again to your socioeconomic group probably you marry people, most people marry people are in a similar socioeconomic group. That's probably what that mostly had to do with. I do think if I'm going to say one thing because a lot of these drugs are on the horizon, they're not yet available, or there's nothing I can hang onto for an FDA approved drug to extend that. I do think the one thing that I would encourage people to do even more than the dietary restriction stuff, it is exercise because that's just generally beneficial in so many different ways. And so, if we can get people doing a little more exercise, I think that would be the one thing that probably could help a lot of people.Eric Topol (42:40):Well, I'm glad we are winding up with that because I think the data from lifestyle, which is exercise as you're pointing out, as well as nutrition and sleep.Coleen Murphy (42:54):All the boring things we already thought, right.Eric Topol (42:55):That we know about, but we don't necessarily put in our daily lives. There's a lot there. There's no question that studies, I think, really have reinforced that even recent one. Well, what a pleasure to talk to you about this and do this tour of the various exciting prospects. I hope I haven't missed anything. I know we can't go over all the pathways, and obviously there've been some bust in the past, which we don't need to review like the famous Resveratrol Sirtuin story, which you addressed in the book. I do want to encourage people that this book is extraordinary. Your work that you put into it had to be consumptive for I don't know how many years of work.Coleen Murphy (43:37):There was many years of work. My editor, we sat down to lunch right after it finished. She was like, so what are you going to work on for your next book?Eric Topol (43:50):Well, it's a scholarly approach to a very important field. If you can influence the aging process, you influence every part of our body function. The impact here is profound, and the contribution that you've made in your science as well as in your writing here is just so terrific. So thank you, Coleen. Thanks so much for joining us today.Coleen Murphy (44:17):Thank you so much. It's been a pleasure.Thanks for listening and/or reading this edition of Ground Truths, aimed at bringing you cutting-edge biomedical advances via analyses and podcasts.All content is free. Voluntary paid subscriptions go to support Scripps Research and have funded our summer intern program. Get full access to Ground Truths at erictopol.substack.com/subscribe

John Cryan joins eBioMedicine to discuss how the microbiome-gut-brain axis regulates social cognition and craving in young binge drinkers.Read the full article:https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00007-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_ebiomContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

If you think you're in control, think again.What invisible forces might be guiding your behaviour, your decisions, your most intimate emotions? Becky Ripley and Emily Knight take a trip into the bizarre nightmare world of the undergrowth, and watch ‘zombie ants' stumble forward, blindly following the orders of the deadly fungi controlling their brains. Parasites often get the upper hand of their hosts, manipulating their behaviour in sometimes horrifying ways. But is that true of humans too? Could we be unknowingly subservient to creatures that live inside us? Do they wish us well, or might they be plotting our downfall?Featuring entomologist Dr David Hughes from Penn State University, and neuroscientist John Cryan from University College Cork.

In a lab in Ireland, a group of scientists stand around a stainless steel table. One of them is holding a device, not unlike a small turkey baster. His free hand plunges into a box on the table and retrieves a mouse. Using his device, he administers the brown solution within…rectally. This unfortunate soul has just received a fecal microbiota transplant. The donor was not another mouse but a human being. And the person in question had symptoms of severe depression. Jonathan speaks to John Cryan, author of the study that showed a relationship between gut and brain. In this episode, we learn more about his fascinating research, how microbes may affect our brain, and to eat to appease your gut bugs. John Cryan is a professor at University College Cork and a world-leading researcher into the relationship between our brain and our gut microbiome.If you want to uncover the right foods for your body, head to joinZOE.com/podcast and get 10% off your personalized nutrition program.Timecodes:00:00 - Introduction02:05 - Quickfire questions03:26 - Are there links between the gut and the brain?06:31 - The gut-brain axis09:17 - How do gut bacteria affect our brains?11:12 - Why does John call the microbiome “the chamber of secrets”?14:20 - Does the microbiome explain drug side effects?15:51 - Are there links between our microbiomes and mental health?20:40 - If we improve our microbiome health can we improve our mental health?24:58 - Can food help improve the microbiome and thus improve mental health?28:33 - Microbiome's effect on behavior29:54 - Actionable advice34:43 - Microbiome in adolescence37:18 - Summary38:26 - Goodbyes38:48 - OutroEpisode transcripts are available here.Follow John: https://twitter.com/jfcryanFollow ZOE on Instagram: https://www.instagram.com/zoe/This podcast was produced by Fascinate Productions.

Dr Sabina Brennan has a fascinating conversation with Prof John Cryan stress neurobiologist and co-author of the Psychobiotic Revolution about the gut and the brain and how bacteria and the food we eat contribute to and are influenced by stress, anxiety, depression and more.The Psychobiotic RevolutionYou can follow Prof Cryan on Twitter @JFCryanYou can read more about his research and access his publications https://www.ucc.ie/en/apc/people/johncryan/Support this show http://supporter.acast.com/superbrain. Hosted on Acast. See acast.com/privacy for more information.

What we learned from a seismometer on Mars, why it's so difficult to understand the relationship between our microbes and our brains, and the first in our series of books on the science of food and agriculture First up this week, freelance space journalist Jonathan O'Callaghan  joins host Sarah Crespi to discuss the retirement of NASA's Mars InSight lander. After almost 4 years of measuring quakes on the surface of the Red Planet, the  lander's solar panels are getting too dusty to continue providing power. O'Callaghan  and Crespi look back at the insights  that InSight has given us about Mars's interior, and they talk about where else in the Solar System it might make sense to place a seismometer. Also this week, we have a special issue on the body's microbiome beyond the gut. As part of the special issue, John Cryan, principal investigator at APC Microbiome Ireland, University College Cork, wrote a commentary piece  on tightening the connections research has made between microbes and the brain—the steps needed to go from seeing connections to understanding how the microbiome might be tweaked to change what's happening in the brain. Finally this week, we have the first installment of our series of author interviews  on the science of food and agriculture. In this inaugural segment, host and science journalist Angela Saini talks to Ousmane Badiane, an expert on agricultural policy and development in Africa, and a co-author of Food For All In Africa: Sustainable Intensification for African Farmers, a 2019 book looking at the possibilities and reality of sustainable intensive farming in Africa. This week's episode was produced with help from Podigy. [Illustration: Hannah Agosta; Music: Jeffrey Cook] [alt: overlapping drawings of microbial populations] Authors: Sarah Crespi; Jonathan O'Callaghan; Angela Saini Episode page: https://www.science.org/doi/10.1126/science.10.1126/science.add1406 About the Science Podcast: https://www.science.org/content/page/about-science-podcast See omnystudio.com/listener for privacy information.

What we learned from a seismometer on Mars, why it's so difficult to understand the relationship between our microbes and our brains, and the first in our series of books on the science of food and agriculture First up this week, freelance space journalist Jonathan O'Callaghan  joins host Sarah Crespi to discuss the retirement of NASA's Mars InSight lander. After almost 4 years of measuring quakes on the surface of the Red Planet, the  lander's solar panels are getting too dusty to continue providing power. O'Callaghan  and Crespi look back at the insights  that InSight has given us about Mars's interior, and they talk about where else in the Solar System it might make sense to place a seismometer. Also this week, we have a special issue on the body's microbiome beyond the gut. As part of the special issue, John Cryan, principal investigator at APC Microbiome Ireland, University College Cork, wrote a commentary piece  on tightening the connections research has made between microbes and the brain—the steps needed to go from seeing connections to understanding how the microbiome might be tweaked to change what's happening in the brain. Finally this week, we have the first installment of our series of author interviews  on the science of food and agriculture. In this inaugural segment, host and science journalist Angela Saini talks to Ousmane Badiane, an expert on agricultural policy and development in Africa, and a co-author of Food For All In Africa: Sustainable Intensification for African Farmers, a 2019 book looking at the possibilities and reality of sustainable intensive farming in Africa. This week's episode was produced with help from Podigy. [Illustration: Hannah Agosta; Music: Jeffrey Cook] [alt: overlapping drawings of microbial populations] Authors: Sarah Crespi; Jonathan O'Callaghan; Angela Saini Episode page: https://www.science.org/doi/10.1126/science.10.1126/science.add1406 About the Science Podcast: https://www.science.org/content/page/about-science-podcast See omnystudio.com/listener for privacy information.

Nick talks to Dr. John Cryan, a Professor of Anatomy & Neuroscience at University College-Cork in Ireland whose lab studies the microbiota-gut-brain axis in health & disease.They touch on a range of topics related to how our gut microbiome affects the brain and body, including: how the microbiome affects aging and immunity; how it affects social behavior, including potential links to autism; how antibiotics and the general hyper-cleanliness of the modern world impacts the microbiome; how it affects neuropsychiatric conditions like depression; how diet influences brain inflammation; towards the end John also shared an interesting example of a food he consumes for gut health.USEFUL LINKSSign up for the weekly Mind & Matter newsletter[https://mindandmatter.substack.com/?sort=top]Follow Nick's work through Linktree:[https://linktr.ee/trikomes]Try Levels Health to monitor your blood sugar & optimize your diet[https://www.levelshealth.com/join?partner=MINDANDMATTER]Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)[https://www.athleticgreens.com/mindandmatter]Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]Learn more about our podcast sponsor, Dosist[https://dosist.com]Download the podcast & follow Nick at his website[https://www.nickjikomes.com]Support the show (https://www.patreon.com/nickjikomes)

The passionate and exuberant Professor John Cryan, Professor & Chair at the Department of Anatomy & Neuroscience, University College Cork joins me on the podcast this week. He chats to me about his exciting microbiome research on the neurobiological basis of stress-related disorders and on understanding the interaction between brain, gut & microbiome. John explains that we are living in a 'microbial world' and why he is interested in examining how the microbiome is shaping aspects of brain physiology and ageing. He also chats to me about growing up in Roscommon, being the first in his family to go to University and his PhD experiences both at home and in Australia. He discusses his experiences in the US, his move to Industry and importantly why he took a pay cut to return to academia. Such fascinating research on how the state of your gut can inform your state of mind, but John also gives excellent insights into how we can 'fuel the fire in the bellies' of young researchers to sustain this career.  Follow John: jfcryan Follow me: MeganHanlon4 This season is kindly sponsored by Bio-Sciences Ltd, now part of Thermo-Fisher Scientific.  

Podcast: The Science Hour (LS 53 · TOP 0.5% what is this?)Episode: Methane - a climate solution?Pub date: 2021-08-15The latest IPCC assessment raised alarm about the rate at which manmade emissions are contributing to climate change. Much of the focus for action is on reducing levels of carbon dioxide, however there is a more potent greenhouse gas, methane, produced by natural and industrial processes which, as Roland Pease tells Drew Shindell of Duke University and lead author on the Global Methane Assessment, is relatively easy to target for reduction. Gut microbes and behaviour Roland speaks to neuroscientist John Cryan of University College, Cork in Ireland who is interested in the effects our gut microbes can have on our behaviour. It's an unusual connection and one which he's been experimenting on in mice. By feeding the faeces of younger mice to older ones he has found that the older ones' took on some of the younger ones' behaviour. Ball lightning Ball lightning is the stuff of legend and the supernatural. And yet there are many reported sightings of this phenomenon. Texas State University's Karl Stephan explains to Roland that he is keen to uncover the science behind these observations. He's running a crowd sourcing project encouraging people to contribute video recordings of any ball lightening events they might observe. Chile mummies And Chile is home to the oldest known mummies in the World. UNESCO world heritage status has been given to a collection of around 300 mummies from Chile's northern deserts. The mummies of babies, children and adults are thought to have been created in response to arsenic poisoning in the region around 7,000 years ago. How can smart tech tackle climate change? Humans are responsible for emitting over 40 billion tonnes of carbon dioxide into the atmosphere every year – and we all know that we need to reduce that figure to prevent devastating climate change. Listener Saugat wonders whether smart technology and artificial intelligence can help us do this more quickly? Green energy will go a long way to tackling the problem, but integrating wind and solar into our current electricity grid is complicated. Marnie Chesterton hears how AI is being used at a wind farm on the island of Orkney to predict periods of high winds, so that excess energy can be turned into hydrogen and stored, then converted back to electricity when there's greater demand. Digital mirrors are also playing a major role in optimising performance, and scientists say cloud-based “twins” of physical assets like turbines can improve yield by up to 20%, allowing engineers to identify problems via computer without ever having to be on site. Marnie visits an intelligent building in London's financial district where sensors control everything from air-conditioning to lighting, and machine learning means the building knows which staff will be on which floor at any given time, switching off lifts that are not in use and adjusting ventilation to save on power. Its designer says incorporating this kind of digital technology will help companies achieve net zero more quickly. And in India, more than half the population are involved in agriculture, but the sector is plagued by inefficiency and waste. Tech start-ups have realised there's potential for growth, and are using drones to monitor crop production and spraying, giving farmers apps which help them decide when and where to fertilise their fields. Image: Livestock farm in Brazil Credit: Photo by Igor Do Vale/NurPhoto via Getty Images Presenters: Roland Pease and Marnie Chesterton Producers: Julian Siddle and Marijke PetersThe podcast and artwork embedded on this page are from BBC World Service, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

The latest IPCC assessment raised alarm about the rate at which manmade emissions are contributing to climate change. Much of the focus for action is on reducing levels of carbon dioxide, however there is a more potent greenhouse gas, methane, produced by natural and industrial processes which, as Roland Pease tells Drew Shindell of Duke University and lead author on the Global Methane Assessment, is relatively easy to target for reduction. Gut microbes and behaviour Roland speaks to neuroscientist John Cryan of University College, Cork in Ireland who is interested in the effects our gut microbes can have on our behaviour. It's an unusual connection and one which he's been experimenting on in mice. By feeding the faeces of younger mice to older ones he has found that the older ones' took on some of the younger ones' behaviour. Ball lightning Ball lightning is the stuff of legend and the supernatural. And yet there are many reported sightings of this phenomenon. Texas State University's Karl Stephan explains to Roland that he is keen to uncover the science behind these observations. He's running a crowd sourcing project encouraging people to contribute video recordings of any ball lightening events they might observe. Chile mummies And Chile is home to the oldest known mummies in the World. UNESCO world heritage status has been given to a collection of around 300 mummies from Chile's northern deserts. The mummies of babies, children and adults are thought to have been created in response to arsenic poisoning in the region around 7,000 years ago. How can smart tech tackle climate change? Humans are responsible for emitting over 40 billion tonnes of carbon dioxide into the atmosphere every year – and we all know that we need to reduce that figure to prevent devastating climate change. Listener Saugat wonders whether smart technology and artificial intelligence can help us do this more quickly? Green energy will go a long way to tackling the problem, but integrating wind and solar into our current electricity grid is complicated. Marnie Chesterton hears how AI is being used at a wind farm on the island of Orkney to predict periods of high winds, so that excess energy can be turned into hydrogen and stored, then converted back to electricity when there's greater demand. Digital mirrors are also playing a major role in optimising performance, and scientists say cloud-based “twins” of physical assets like turbines can improve yield by up to 20%, allowing engineers to identify problems via computer without ever having to be on site. Marnie visits an intelligent building in London's financial district where sensors control everything from air-conditioning to lighting, and machine learning means the building knows which staff will be on which floor at any given time, switching off lifts that are not in use and adjusting ventilation to save on power. Its designer says incorporating this kind of digital technology will help companies achieve net zero more quickly. And in India, more than half the population are involved in agriculture, but the sector is plagued by inefficiency and waste. Tech start-ups have realised there's potential for growth, and are using drones to monitor crop production and spraying, giving farmers apps which help them decide when and where to fertilise their fields. Image: Livestock farm in Brazil Credit: Photo by Igor Do Vale/NurPhoto via Getty Images Presenters: Roland Pease and Marnie Chesterton Producers: Julian Siddle and Marijke Peters

Bonnie J. Kaplan, Ph.D. & Julia J. Rucklidge, Ph.D.: “Our brains are set up to require roughly 30 micronutrients: 15 minerals and 15 vitamins.” Kaplan and Rucklidge, leading scientists and co-authors of The Better Brain, join mbg co-CEO, Jason Wachob, to discuss how your food affects your stress, plus: - What we're still getting wrong about nutrition & brain health  - The best supplements for mental health - How a vegan diet affects your brain - The connection between psychobiotics & depression - How to use food to enhance your emotional resilience Referenced in the episode: - Kaplan & Rucklidge's book, The Better Brain. - Scott Anderson, John Cryan, Ph.D., and Ted Dinan, M.D., Ph.D.'s book, The Psychobiotic Revolution.  - Rucklidge's study of micronutrients to treat stress and anxiety from the Christchurch earthquakes. - Rucklidge's comprehensive review on psychobiotics. - Rucklidge's research on ADHD and emotion dysregulation. - SUN study in Spain on the Mediterranean diet and depression. Enjoy this episode sponsored by smartwater! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com.

Victoria Gill talks to climate scientist Friedericke Otto about the Intergovernmental Panel on Climate Change's new landmark report. The report this week states that the evidence for humanity's role in changing global change is now unequivocal. Dr Otto was a lead author on the chapter on extreme weather events and explains how human influence can be attributed to the increasing incidence and intensity of heat waves and heavy rainfall events. Also in the programme: Immunological evidence to support a covid vaccine booster programme in the UK, with virologist Jonathan Ball of the University of Nottingham. Faecal transplants that rejuvenated the memory and the brains of elderly mice, with neuroscientist John Cryan of University College Cork. A website for the public to report their sightings and upload their videos of ball lightning, with electrical engineer Karl Langham of Texas State University, San Marcos.

"I'm not saying this is going to cure your depression, but I am saying that it stands a good chance of fixing up your gut, and if your depression is gut-related this could have a big impact on you. This could be a big explanation for the worldwide epidemic of depression that is going on because it is very strongly correlated, not caused, but correlated to the extraction of fiber from our foods."      Episode Description: We begin with an overview of the microbiome especially as it functions as part of our immune system. From there we discuss the connection between the gut and the brain and how each influences the other. We consider the complex and serious condition that is depression which has many causes and many treatments. While the use of pre and probiotics that have impact on one's mind, psychobiotics, has not yet been demonstrated to have efficacy in the treatment of depression in double-blinded research there are many promising signs that it will. It is also available to be used as an adjunct to other well-researched interventions. Diet is key to a healthy gut and a healthy low inflammation body and brain. Scott makes a number of dietary recommendations for a robust and diverse microbiome. We close with his sharing his personal story of healing through the use of a prebiotic.     Our Guest: "Scott Anderson - I've always been fascinated with science and technology. After graduating with a degree in Physics and Math, I jumped into the world of personal computers, forming Sonoma Softworks, one of the first personal computer software companies in California. I wrote the first educational software published by Apple (Supermap), the first PC database manager (Datadex), and the first vector animation program (Fantavision, a forerunner of Flash). I produced the 3D educational game LEGO Island, coordinating marketing and development efforts with Microsoft, Intel, Adobe, and LEGO. I was a co-founder of BigFix Software, which was subsequently purchased by IBM.  I have written seven books on technology and hundreds of articles on subjects ranging from video to advanced medicine. I co-authored one of the first books on stem cells, Human Embryonic Stem Cells, with Dr. Ann Kiessling of Harvard. The book is used in graduate schools throughout the country. My latest book is The Psychobiotic Revolution, coauthored with John Cryan and Ted Dinan from National Geographic. I'm currently writing Mood by Microbe for Psychology Today." 

Mental health and its relationship with the gut and food. I chat with UCC professors John Cryan and Ted Dinan about their world-leading research into psychobiotics See acast.com/privacy for privacy and opt-out information.

Holistic Veterinarian, Dr. Nick Thompson discusses a wide range of topics in this week’s episode of Dog Cancer Answers. Educating our listeners on everything from the microbiome, the science behind epigenetics and cancer gene expression, your dog’s immune system. And how you can help keep your dog flea, tick, and worm free without using all the harsh chemicals in traditional over the counter or prescription antiparasitic medications. In one information packed episode with Dr. Nick Thompson, you will learn about your dog’s gut health. The importance of good nutrition in fighting cancer. The science behind the expression of cancer genes. A list of Dr. Nick’s favorite cancer fighting supplements and herbs. And so much more!Links Mentioned in Today’s Show:The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog’s Life Quality and Longevity by Dr. Demian Dressler and Dr. Susan Ettinger.Dr. Nick’s site—contains lots of other resources, recommendations, and contact infohttp://holisticvet.co.uk/Books and Talks Dr. Nick recommends: “Entangled Life” by Merlin Sheldrake—fungi and yeast may save us yet! https://www.merlinsheldrake.com/entangled-life“Give Your Dog a Bone” by Dr. Ian Billinghurst, which helped Dr. Thompson turn to the raw food diet https://drianbillinghurst.com/product/give-your-dog-a-bone/“Raw Meaty Bones” by Tom Lonsdale, precursor of the BARF diet  http://www.rawmeatybones.com/book.phpDr. John Cryan’s TED talk “Food for thought: How gut microbes change your mind” https://www.tedmed.com/talks/show?id=293045Dr. Cryan’s book on gut bugs influencing our brains “The Psychobiotic Revolution” http://psychobiotic-revolution.com/Dr. Nick’s recommended books on herbs http://holisticvet.co.uk/index.php/reading/reading-herbal-medicine/The 2018 French study linking processed food intake with cancer rates in humans https://www.bmj.com/content/360/bmj.k322Raw Food Resources for Everyone: The Raw Feeding Veterinary Society https://rfvs.info/ (Click under “About Us” for info about the November 2020 conference) Answers Pet Food (US based raw food company) https://www.answerspetfood.com/KetoPet Sanctuary (free education on ketogenic pet diet) https://www.ketopetsanctuary.com/The Raw Feeding Veterinary Society’s public Facebook forum  https://www.facebook.com/RawFeedingVets/Other Links: What is epigenetics?  https://www.livescience.com/37703-epigenetics.htmlAbout Today’s Guest, Dr. Nick Thompson: Nick is a fully trained vet with over twenty years’ experience. He has also trained in homeopathy, acupuncture, natural nutrition, and veterinary herbal medicine. He will use both ‘complementary’ and conventional approaches, together with a large dose of old-fashioned common sense to try to establish what is really wrong with your animal and fix it. Nick has a special interest in immunology, internal medicine in all species, and Autism spectrum behavior in dogs and horses. Working closely with conventional colleagues and friends in the veterinary world, we, together with patient and owner, make a hard working team focused and committed to changing health and behavior for the better. Holisticvet is based in Bath, Somerset. Dog Cancer Answers is a Maui Media production in association with Dog Podcast NetworkThis episode is sponsored by the best-selling animal health book The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog’s Life Quality and Longevity by Dr. Demian Dressler and Dr. Susan Ettinger. Available everywhere fine books are sold. Listen to podcast episode for a special discount code. If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&A episode, call our Listener Line at 808-868-3200.Have a guest you think would be great for our show? Contact our producers at DogCancerAnswers.comHave an inspiring True Tail about your own dog’s cancer journey you think would help other dog lovers? Share your true tail with our producers.Sign up to receive the Dog Cancer News weekly newsletter at DogCancerNews.com

Professor Paul Cotter on the scientific evidence supporting the benefits of fermented food and why these foods are great for gut health and the microbiome. We also cover sports, exercise and the impact on your microbiome and much more.   Bio:    Paul is a molecular biologist with a focus on food. He coordinates the European Union’s H2020 Innovation Action related to food and the food chain, and heads Teagasc’s DNA high throughput sequencing facility. A multiple award winner himself, his laboratory has been named Laboratory of the Year Award five times. In addition to his roles at Teagasc and APC, he is a principal investigator at Vistamilk SFI Centres and Food for Health Ireland. He has published extensively and was included in the Clarivate list of highly cited researchers in 2018 and 19.    Topics discussed:   Paul passion with Science and the Microbiome The Virus Issue The situation in Ireland Beneficial Microbes The Hygiene Hypothesis Microbes and the Food Industry Insurance policy Pasteurisation Alternative way of Food Preservation The advent of Fermented Foods Fermented Foods and Gut Health Fermented foods and Allergen removal Removal of Anti- Nutrient Compounds What is Fermentation? Mik Kefir Fermentation How does fermented foods cultures vary around the world Fermented Food - Gut Brain Axis- Anxiety and Depression Ted Dinan and John Cryan https://www.nourishmeorganics.com.au/blogs/nmo-gut-health-journal/the-psychobiotic-revolution-mood-food-and-the-new-science-of-the-gut-brain-connection-with-professor-ted-dinan?_pos=1&_sid=f556b7398&_ss=r Kefir Grains with Coconut Milk DNA based testing of Fermented Foods Alpha and Beta Diversity- PCOA/ Clustering Diversity of the Microbiome and Health Diversity and Ecosystems Clostridium difficile infections - Treatments for Clostridium Difficile Fermented Foods and Gut Diversity What are Postbiotics  Benefits of Postbiotics Introducing fermented foods early Birth modality, Infant feeding and the microbiome Training the Immunity System Variety of fermented foods The Scientific Evidence behind fermented foods The Fermented Foods Revolution The Science of Milk Kefir The Health Benefits of Milk Kefir The Difference between Milk Kefir Grain and Starter Cultures Definition of Real Kefir The Russian Method of Milk Kefir Production Artisan Kefir Making Genome Sequencing of Kefir to identify best attributes Standard of Identity regarding Kefir Kefir and Alcohol Legislation the authenticity of fermented foods Scientific Benefits of Milk Kefir Tumour Suppression Blood Pressure Wound Healing IBD Anxiety Human Clinical Trials Sports Enhancement, Exercise and the Microbiome Is High Intensity or Low Intensity Exercise the best for the microbiome? Exercise Whey Protein and Creatine Kinase (CK) Importance of Diet Paul’s top Gut Health Tip      Brought to you by:   Nourishme Organics your online shop for Fermentation Kits   https://www.nourishmeorganics.com.au/   Shop online today and use code cotter for 10% off Fermentation Kits   https://www.nourishmeorganics.com.au/collections/fermentation-accessories   Connect with Professor Paul Cotter   Website- https://apc.ucc.ie/paulcotterapex/   Connect with Kriben Govender:    Facebook- https://www.facebook.com/guthealthgurus Instagram- https://www.instagram.com/guthealthgurus Youtube-https://www.youtube.com/c/guthealthgurus?sub_confirmation=1 Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/ Deuterium Depletion Support Group : https://www.facebook.com/groups/mitowellness/   Download links               If you enjoyed this episode and would like to show your support:   1) Please subscribe on Apple Podcasts, give us 5 stars and leave a positive review     Instructions:   - Click this link  https://itunes.apple.com/au/podcast/gut-health-gurus-podcast/id1433882512?mt=2   - Click "View in Itunes" button on the left-hand side - This will open the Itunes app - Click the "Subscribe" button - Click on "Ratings and Reviews" tab - Click on "Write a Review" button   Non-Itunes users can leave a Google Review here: https://goo.gl/9aNP0V     2) Subscribe, like and leave a positive comment on Youtube   https://www.youtube.com/channel/UCq5KxLvGIY4r6SqNaAphEUw?sub_confirmation=1   3) Share your favourite episode on Facebook, Instagram, and Stories 4) Let your friends and family know about this Podcast by email, text, messenger etc   Thank you so much for your support. It means the world to us.

At some point in your life, you’ve likely been told to “trust your gut” when making a decision or experienced a “gut reaction” to external stimuli. Medical research indicates that these gut idioms might just be right about the role of the gut! It turns out that the gut microbiome communicates with the brain and can potentially influence our behavior. Researchers have named this link the gut-brain axis and it provides a robust communication network between the gastrointestinal tract and central nervous system. At its core is the enteric nervous system which has more than 5 times the number of neurons in our brains and trillions of microorganisms. This system has been dubbed the “second brain” or the “gut-brain” for its influence on our overall physical and mental health. Our guest today is neuroscientist John Cryan, PhD. Professor Cryan investigates how the gut microbiome affects the mammalian brain. He is Chair of the Department of Anatomy and Neuroscience and Principal Investigator in the Alimentary Pharmabiotic Center at University College of Cork (Ireland). Dr. Cryan’s research has demonstrated the bi-directional relationship between our gut and emotional and mental wellbeing. In this episode Dr. Weil, Dr. Maizes, and Professor Cryan discuss the role the vagus nerve plays in regulating homeostasis, how chemicals released in the gut send signals to the brain, how maternal bacteria influence our early development, the link between sleep and gut health, and how diet can influence this complex system.

60 - „So, wie der Holzschnitzer Geppetto die Holzmarionette Pinocchio an Fäden durch den Raum tanzen lässt, steuern die Darmmikroben uns.“- Prof. John Cryan, University College in Irland Der menschliche Körper ist kein einzelner Organismus, sondern eine Ansammlung ganz vieler Mikroorganismen und teilweise fremdgesteuert? Du bist also nicht du, sondern durch die Mikroorganismen, Bakterien und Bakterienkulturen geleitet? Und die Flora, die auf deinem Körper herrscht, hat einen Einfluss darauf, ob du dich glücklich fühlst und gesund bist? Um diese Fragen zu beantworten beleuchtet dieser Artikel die Mikroorganismen, insbesondere die Darmflora. Gibt es etwas im Darm, das den menschlichen Körper steuert?

You’ve no doubt sat in your science classes ( gosh that feels like a long time ago) and learned about the theory of evolution.  Quick refresher: It’s about how the fittest survive the harsh changes in the environment and comes out as the victor. But we regularly hear about new diseases, giving us more reasons to be vigilant about our overall health. How are we supposed to get through life as healthily as we could? With the spread of contagious diseases and health risks, our body needs a line of defense that would keep us immune and protected. Hold up, don’t get too stressed about it! We do have ways to protect our health, and it’s not just through supplements. Presenting... the armada of teeny-tiny microbiomes in our gut! That’s right! These microorganisms stand at the vanguard of all the dangerous battles that we face every day!  Did you know that aside from shielding us from potential harm from our environment, they can also affect our cognitive processes? They do so much of the heavy lifting to break food down into body building, brain nourishing information. Yes, that’s right. And knowing more about how it all works can definitely help us all have sharper minds and better memory health.Let’s put your battle gear on as we learn from the National Geographic science communicator, Gut Bug Pioneer and author, Scott Anderson. He’ll tell us how to build on our natural line of defense and train it to fight at its best. I’m sure you’re now also asking, “How can I keep their numbers growing?” No worries, we got you.  In this show you’ll learn about:  The role of the gut microbes in your immune system  How gut microbes affect your mental health How your diet plays a significant role in maintaining a healthy level of good microbes inside your body.  In today’s show, you will learn how to optimise your health and cognitive fitness though the power of your microbiome!  Let’s now power up our body’s line of defense and boost the bugs for brain power!  Listen To The Podcast Now.  About Our Guest Scott C. Anderson is a scientist who specialises in health and technology. He is the author of several science books, including Human Embryonic Stem Cells and co-authored multinational best selling The Psychobiotic Revolution. The Role of Microbes and Our Brain Health  Why Do We Have These Bacteria?  We can never get away from bacteria. They are ubiquitous and coat every surface of the earth. Certain bacteria grew with us, and we grew up with them in a way that was beneficial to both of us. A lot of them are unique to humans. These bacteria have become used to us. They help in protecting us from pathogens. Two Forms of Human Immunity  First, the innate immune system is fighting bacteria in our environment.  Second, the adaptive immune system helps us deal with things our body has never encountered before. This system functions more like hit or miss.  How Can Bacteria Build Our Adaptive Immunity It takes a bacterium to fight a bacterium. We need to live together with our gut bacteria and recruit them to fight the pathogens of the outside world.  It can be good or bad, depending on who is in charge.  A lot of those bacteria are what makes a good set of microbes in our gut called microbiota.  The Human Gut and Its Microorganisms The gut consists of the whole alimentary canal, starting from our mouth all the way to the anus. Our microbiome is composed of a broad variety of microorganisms that have specific roles to play within the alimentary canal. There are situations when some of the harmful bacteria, microorganisms and their metabolites can get into our blood system, especially when our immune system is down. That’s when we get inflammation, the immune system’s alarm bells are starting to ring. They can also get into the brain through the blood and cross the blood brain barrier. Bacteria associated with gingivitis have been found in people's brains living with dementia on autopsy.  How Bacteria Can Affect the Brain  First, it can affect the brain through the vagus nerve. The second way is through the immune system. The third is through the hormonal system through the HPA axis (hypothalamus, pituitary and adrenal gland). Now, researchers are looking into whether bacteria can get to our brain through the metabolites they produce. Drugs and Our Immune System Recent studies would show that some medications we are taking are fighting the bacteria; in the process, they are also killing our own cells. There is collateral damage when we try to fight bacteria and end up damaging our cells as well. How Can We Create a Healthy Relationship with Our Microbiome?   One of the challenges is not knowing enough about probiotics. Some of the available supplements in the market cannot be trusted. However, we can get probiotics without resorting to supplements. We can do this by consuming probiotic foods like kimchi, yoghurt and sauerkraut.  Changes in diet can lead to a more diverse microbiota. The more different species you have, the better.  The Mediterranean diet has been strongly associated with reduced inflammation. Fish, the main protein source in the diet, has high omega 3 ( DHA= docosahexaenoic acid), and EPA = eicosapentaenoic acid) which is a key fatty acid for the brain. Several studies associate higher omega-3 intake with decreased age-related mental decline and a reduced risk of Alzheimer's disease You can also lower inflammation by feeding your gut bacteria fibre. Fibre! Fibre! Fibre! Oi! Oi! Oi!  Almost every known chronic disease like cancer, Alzheimer’s, diabetes and Parkinson’s have their roots in systemic inflammation. Many systemic inflammation comes from the gut.  Aim to keep a robust balance of bacteria, as one pillar to supporting your memory health. There’s almost a upside for every single organ in your body,  especially your beautiful brain. It’s a win - win game really. Happy Bugs = Happy Life  Bacteria and Protein Build-Up Our immune system tracks down and identifies some of the building blocks of the proteins involved with bacteria. The immune system may be in charge of the goodness or badness that comes as a consequence.  Our immune system may react differently depending on the medicine that will be given to a person.  Food Recommendation  Avoid foods which contain preservatives and emulsifiers and those that come farther than the source.  Avoid foods with pesticides, herbicides and fungicides. These chemicals can be poisonous to your microbiome gut citizens. Try the Mediterranean, Nordic or Japanese diet. Eat whole foods and whole grains. Have as much fibrous food as possible.  Resources The Psychobiotic Revolution by Scott Anderson with John Cryan and Ted Dinan Healthy aging and dementia: findings from the Nun Study: The Nun Study is a longitudinal study of 678 Catholic sisters 75 to 107 years of age who are members of the School Sisters of Notre Dame congregation. https://www.ncbi.nlm.nih.gov/pubmed/12965975     How You Eat Directly Impacts Your Mood:  New Scientist article: https://www.newscientist.com/article/mg24332460-500-how-what-you-eat-directly-influences-your-mental-health/    Gut and Mood Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., … Raes, J. (2019). The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 1. https://doi.org/10.1038/s41564-018-0337-x    You can reach out to Scott on his website, Facebook, and Twitter account. You may also want to check out Psychobiotic Revolution to learn more about how microbes can affect your mood and help maintain your brain health. Enjoy The Podcast? If it’s a “Oh Yes I did David!”  Then please, do yourself a huge favour and subscribe to the podcast.  5 Star Review Worthy? If it is we’d love your review. It really does go a long way to help us reach and serve more people.  Do you want to help other people prevent avoidable memory loss? Yes? One simple way is to share what you’ve learned today.  Here’s How:  Take a screenshot of the podcast, post it on social media, make a comment and link to the show, is one, very easy way to help cement your learning and brings you closer to action as well as gifting to others the seeds of better memory health!  FREE Guide To Help Prevent Memory Loss Grab a free copy of the 9 Principles for Memory Health For Life CLICK HERE.  A simple framework to reduce your risk for memory loss. Go on, what have you got to lose?   Of course you can reach me, David Norris, here on the website and connect with me on LinkedIn or Twitter.   To better memory health,  David P.S. Did you get the free guide?  If not, here’s the link. Disclaimer: The purpose of Memory Health Made Easy Podcast is to educate and to inform. It is no substitute for professional care by a doctor or qualified professional. This podcast is provided on understanding that it does not constitute medical or personal professional advice or services. Instead, we would encourage you to discuss your options with a health care provider who specializes in your particular needs.

A recent poll of junior lawyers suggested that 93% of participants experienced distress in the last month and 19% had felt unable to cope. Those across the legal profession are experiencing higher than average levels of stress, anxiety and alcohol abuse. Can the profession adapt to openly accommodate wellbeing to balance the demands of the job? Claudia Hammond talks to Emma Jones, Senior Lecturer in Law at the Open University who is now conducting research with the charity LawCare on mental health in the legal profession, and Alex McBride, who’s a criminal barrister turned author. We all know that some of us are more sociable than others, depending on our personalities, experiences and the situations we find ourselves in. But could the microbes in our gut also play a part? John Cryan of the APG Microbiome Centre in Cork discusses his latest observations across species and in humans. Three quarters of mental health problems first occur before we reach our mid-20s. Yet much of the research is done with adults. Dame Til Wykes, Professor of Clinical Psychology & Rehabilitation at Kings College London, discusses a new initiative - the young people mental health advisory group - to ensure the best possible research is being carried out through liaison with a group of teenagers who have experienced mental health difficulties themselves. Producer Adrian Washbourne

Language is magic and it's time to conjure a different story.I hope that in sharing this journey with me, you will discover your own antidote to the velocity of modern life. At the very least you will sleep sounder, dream like Netflix, levitate in mind and spirit, and learn how to get high on your own supply.Featuring Kelly Le Brock, Harry Potter, Hagrid, Michael Pollan, Joe Rogan, John Cryan, Ted Dinan, Robin Williams, Withnail, The Sorcerer's Apprentice, The 90's and Marc Andreessen.Musical influences can be found on Spotify at the GABA Sounds Playlist. See acast.com/privacy for privacy and opt-out information.

Do the bugs in your gut influence whether you are anxious, depressed, clear-headed, or distracted? Well, it turns out quite possibly. Future depression prescriptions may be custom probiotics rather then Prozac. I invited Scott Anderson the author of the The Psychobiotic Revolution to speak with us today about this most interesting topic. We dive into this and the gut-brain axis, how diet influences the microbiota, fecal transplants, measuring the microbiota, anxiety, depression, and more. About our guest: Scott is a scientist and a science writer who was drawn from the wine country in California to work with horses in Ohio. There, Scott set up a laboratory to help develop equine prebiotics. He found that a less diverse microbiota was associated with colonic ulcers and poor performance. That ultimately led him to John Cryan and Ted Dinan, two pioneers of the gut-brain axis who found that gut microbes can affect the behavior of mice. Scott ended up writing a book with Cryan and Dinan called The Psychobiotic Revolution, from National Geographic. It is now going into the second printing. resources from the episode: Dinan, Melancholic microbes: a link between gut microbiota and depression? Tillisch study. Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women --- Support this podcast: https://anchor.fm/adam-rinde/support

 Episode 1: Pearse chats to Dr John Cryan about the science behind the fact that you are what you eat. Prof. Cryan is a leading Neuroscientist based in University College Cork whose research is focused on understanding the interaction between brain, gut & microbiome and how it applies to stress, psychiatric and immune-related disorders at key time-windows across the lifespan. Don't know what a microbiome is? Well listen to this podcast to find out... 

Dr John Cryan, a neuropharmacologist and microbiome expert from the University College Cork, researches the interactions between the brain and the collection of microbes in the gut, and how that relationship affects stress, psychiatric health, and immune-related disorders. In his latest book, The Psychobiotic Revolution, Professor Cryan and colleague Ted Dinan write about research showing that beneficial microbes can improve mood.

The microbiome is an interesting and rapidly growing area of research. There are trillions of microbes inhabiting our bodies, and we have more microbial cells than we do human cells. Dr. John Cryan, PhD, professor and Chair of the Department of Anatomy and Neuroscience at the University of Cork, Ireland, talks about everything involved with the microbiome, from mood to pain to neurotransmitters through our nutrition. His current research includes the neurobiological basis of stress-related disorders including depression, anxiety, pain, and drug dependence. His research group is also focused on understanding the interaction between brain, gut, and microbiome and how it applies to stress and immune related disorders, including irritable bowel syndrome, obesity, and other disorders such as autism. His research into the microbiome has far-reaching public health implications - from how he views his area and sections to how the microbiome influences brain development, chronic pain development, and of course the impact of probiotics on mood. Dr. John Cryan, PhD discusses the influence of the microbiome on pain, mood and stress. Sign up for the latest episode at www.drjoetatta.com/podcasts.   Love the show? Subscribe, rate, review, and share! Here’s How » Join the Healing Pain Podcast Community today: drjoetatta.com Healing Pain Podcast Facebook Healing Pain Podcast Twitter Healing Pain Podcast YouTube Healing Pain Podcast LinkedIn

Dr Chatterjee talks to Professor John Cryan, world-leading researcher on the gut-brain axis and Professor of Anatomy & Neuroscience about how the connection between our gut and our brains affects all aspects of our health, including stress, depression, anxiety and IBS.Show notes available at drchatterjee.com/johncryanFollow me on instagram.com/drchatterjee/Follow me on facebook.com/DrChatterjee/Follow me on twitter.com/drchatterjeeuk See acast.com/privacy for privacy and opt-out information.

The chaotic removal of Deutsche Bank's chief executive John Cryan and the rushed appointment of Christian Sewing as his successor has created confusion about the bank's strategy. Patrick Jenkins discusses the weekend's events and what they mean for the German lender with the FT's Olaf Storbeck and Laura Noonan. Music by Kevin MacLeod See acast.com/privacy for privacy and opt-out information.

Host Jonathan Ferro spoke with Ken Veksler, Director at Accumen Management, and David Goodman U.K. Economy Reporter, about Deutsche Bank possibly replacing CEO John Cryan, Brexit, and markets.u0010Jonathan also spoke with Joe Weisenthal, executive editor of news for Bloomberg Digital and co-anchor of "What'd You Miss?", and Luke Kawa, Cross-asset reporter at Bloomberg News, about Facebook, the relief rally, and the week ahead.

Wie reagieren die großen Wirtschaftsmächte auf US-Präsident Trumps Einfuhrzölle? Davon hängt vieles ab. Einige Ökonomen sprechen sogar schon von einem drohenden weltweiten Handelskrieg. Was das bedeuten könnte und was Trump mit seiner protektionistischen Wirtschaftspolitik bezweckt, erklärt Marcus Gatzke, Leiter des Ressorts Politik, Wirtschaft und Gesellschaft bei ZEIT ONLINE, im Nachrichtenpodcast. Den CEO der Deutschen Bank, John Cryan, beschreiben viele Journalisten als eher grummeligen Zeitgenossen. ZEIT-ONLINE-Chefredakteur Jochen Wegner hat ihn während des Technikfestivals South by Southwest (SXSW) in Austin, Texas, in einer kleinen Bar vor Publikum interviewt. Cryan war gut gelaunt, humorvoll und hat ganz nebenbei Details über die Bonuszahlungen der Deutschen Bank verraten, die die Finanzwelt ziemlich überrascht haben. Wir sprechen mit Jochen Wegner über die Begegnung. Es gibt auch was zu lachen. Außerdem geht es um nackte Brüste. Wenn Sie uns kontaktieren möchten, schreiben Sie uns gerne eine Email an wasjetzt@zeit.de.

Patrick Jenkins and guests discuss John Cryan's signal that 'normal' bonuses and pay rises are back at Deutsche Bank, the introduction of Mifid II regulations this week and why weatlh managers are directing greater attention towards female clients. With special guest Kendra Thompson of Accenture. See acast.com/privacy for privacy and opt-out information.

Veteran science journalist Scott Anderson collaborated with 2 medical researchers--Dr. John Cryan and Dr. Ted Dinan-- to produce an interesting book: The Psychobiotic Revolution: Mood, Food and the New Science of the Gut-Brain Connection. The timing is interesting, with this holiday season, we can think of it as a gift of awareness, and potentially new ideas for some life change plans as the new year approaches.

My guest is Professor John Cryan, who is Professor and Chair of the Department of Anatomy and Neuroscience at University College Cork, and along with his long-time collaborator, Prof Ted Dinan, has lead much of the burgeoning field of the gut microbiome and the gut-brain axis.In this episode we talk about what exactly is meant by the term ‘gut-brain axis’, the link between the gut and brain disorders such as Parkinson’s Disease and depression and what you can do to look after your own gut bugs.It is a fascinating conversation full of useful information, and he also answers some questions from the audience, so make sure you have your notebooks at the ready. See acast.com/privacy for privacy and opt-out information.

Patrick Jenkins and guests discuss Deutsche Bank's difficulties as chief executive John Cryan comes under pressure from investors, the delay in the TSB's latest IT project, and who the new HSBC chairman has picked as his CEO. See acast.com/privacy for privacy and opt-out information.

In our Cerebrum article, “Gut Feelings on Parkinson’s and Depression,” microbiome pioneers Ted Dinan and John Cryan write that “in the next few years, new research will hopefully affirm the validity of modulating the gut microbiota as a viable therapeutic strategy for treating neurological and psychiatric disorders.” In this podcast, Dinan, M.D., Ph.D., professor of psychiatry and in the APC Microbiome Institute at University College Cork in Ireland, discusses the recent research breakthrough that links microbiota to Parkinson’s disease and depression, some of the gut-axis research occurring in their 45-member lab, and other issues surrounding what many label “the second genome.”

"Our dietary choices play a major role in determining whether we are going to live into our 80s and 90s and even beyond with a good, functioning brain, or like 50% of people who live to be age 85, we will experience brain decline in the form of Alzheimer's which is a preventable disease."- Dr. David Perlmutter  When we think about brain health, we don't think that our gut has anything to do with it. However, the fact is that the gut has everything to do with how our brains function as we grow older. Neurologist and New York Times Best Selling Author, Dr. David Perlmutter has witnessed the damaging effects that a poor diet can have on our brains. Today is perfect timing with the launch of his new book, The Grain Brain Whole Life Plan, as he shares why we are vulnerable to develop brain degenerative disease and how we can take matters into our own hands in order to live long, healthy lives with a bright mind that is free of illness.   Make the Choice to Have a Healthy Brain Even if a relative of yours was diagnosed with a brain degenerative disease such as Alzheimer's, you have the amazing opportunity to make lifestyle choices to ensure your brain's health. Factors such as sleep, nutrition, stress levels, and exercise can impact your health, but you can also take advantage of them to improve your wellness and lower the chances of brain decline.   Connecting Wellness And Gut Health   "It's a bit humbling to recognize that mood is regulated by our gut. Not only through the process of controlling inflammation, which is a cornerstone player in depression, but that around 90% of our levels of dopamine and serotonin are not manufactured in the brain. They're mostly manufactured in the gut." - Dr. David Perlmutter     If the gut is leaky and we lack serotonin, it can be linked to feelings of depression. In a study with probiotic yogurt, researchers found a dramatic change in brain function and mood in the test subjects that ate the yogurt compared to those who did not.   Build a Healthy Gut At this moment, there is a diverse community of healthy, gut bacteria living inside of us. If any harm comes our gut's way, it can increase the chances of having a leaky gut. This leaky gut can lead to inflammation and degenerative diseases including: Alzheimer's Parkinson's Diabetes Multiple Sclerosis Cancer The right way to eat food, is to focus on following a diet that helps reduce the chance of a leaky gut and inflammation from happening inside the body.   Do You Have a Leaky Gut? In today's world, we should assume that it is likely that we all have somewhat of a leaky gut. We would have to take a test or participate in a study to know for sure by having an LPS level done in a lab. There's a higher chance that you have a leaky gut if you have an inflammatory condition such as: Depression Early onset Parkinson's Alzheimer's Joint issues Skin inflammation Autism What can you do to heal your leaky gut? To help heal your gut, remove any offensive agents that may be harming it such as any overuse of: Antibiotics GMOs Drinking chlorinated water Artificial sugars and sweeteners Acid blocking drugs Proton pump inhibitors Non-steroid and anti-inflammatory drugs Stress To heal our gut, we need to stimulate and increase the diversity of the organisms that live inside of the gut by exercising and eating foods that are rich in pre-biotic fiber that helps nurture our gut bacteria: Mexican yam/ jicamo Onion Garlic Leek Dandelion greens Kimchi Kobucha Yogurt Fermented vegetables   The Truth About Sugar and Gluten   "Inflammation caused by sugar consumption can lead to diabetes and quadruples your chances for Alzheimer's Disease." - Dr. David Perlmutter   For decades, we've been told that gluten and sugar is good for our health and that fat is bad. However, recent research has shown that this is the exact opposite. Healthy fat is good for both the body and brain function, but gluten and sugar (including artificial sugar and sweeteners) can cause our insulin levels to spike which leads to inflammation in the body. In fact, according to Dr. Perlmutter, artificial sweeteners were created to help people control the amount of sugars in their diet, but still be able to taste something sweet. Unfortunately, artificial sugars and sweeteners can dramatically increase a person's risk for obesity and diabetes. Take your health into your own hands by making good choices. Eat healthy and avoid any sugary drinks, high gluten foods, and anything labeled "sugar free" or "contains artificial sugars."   The Best Sources of Healthy Fat There's a lot of taboo hanging around the words, "fat" and "fatty food." However, healthy sources of fat are great for our bodies and important for our brain's health. According to Dr. Perlmutter, the brain is already made up of a lot of saturated fat and even human breast milk is 50% saturated fat. If you want to ensure that you follow a healthy diet, use the Ketogenic and Mediterranean diets as a good model to follow. The best sources of healthy fats include: Extra virgin olive oil (organic) Fatty fish with DHA Nuts Seeds Avocado Grass-fed and free-range meat Olive oil particularly is good source of polyphenols that act as antioxidants and nurture the gut bacteria. This source of healthy fat provides both mono and unsaturated fats for our brain cell building blacks. When you follow a Ketogenic or Mediterranean based diet, but add extra amounts of olive or cocnut oil, your cognitive function can improve dramatically.   A Diet to Help Prevent Alzheimer's Disease To better understand your body and gene makeup, there are numerous services available from companies that offer biometrics tests including: Wellness FX 23andMe Promethease The sooner you better understand your genes and if there is a chance for you to have an inflammatory disease, the sooner you can take action to fight against it. Depending on our dietary fat composition, there is a risk of dementia or Alzheimer's Disease, but it can be handled by following a diet that includes food that is high in healthy fats. As mentioned before, we should be eating more nuts, seeds, olive oil, and avocado. Monosaturated fats such as almond oil, almond butter/nut butter, an oleic acid in sunflower oil can help prevent degenerative brain disease. However, we should avoid canola oil, vegetable oil, corn oil and other modified oils in our diets. These are the unhealthy oils that can harm our body and brain function.   Build a Healthy Brain with Aerobics If you want to build a healthy brain, change your diet, but also increase the amount of aerobic exercise. Working out helps to turn on BDNF (Brain-derived neurotrophic factor) which serves as a growth hormone for the brain and helps increase the number of memory cells throughout our lifetime. People who exercise regularly can reduce their chances for Alzheimer's Disease by 50%! One of the best things you can do to help your brain stay healthy is to include aerobic exercise for 20 minutes every day.   6 Key Factors For a Whole Life Plan According to Dr. Perlmutter, there are 6 key factors and goals that take place in creating a whole life plan for a healthy brain and gut: Reducing and controlling inflammation Turning the body into a fat burning machine Balancing levels of bacteria Balancing hormones and increasing leptin sensitivity Taking care of our genes Balancing our life   About Dr. David Perlmutter Dr. Perlmuter is a Neurologist and Fellow of the American College of Nutrition who received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He is the author of: The Better Brain Book and the #1 New York Times Bestseller, Grain Brain, and Brain Maker, also a New York Times best seller. He is recognized internationally as a leader in the field of nutritional influences in neurological disorders. Over the past 35 years, Dr. Perlmutter has been interviewed on many nationally syndicated radio and television programs including 20/20, Larry King Live, CNN, Fox News, Fox and Friends, The Today Show, The Oprah Winfrey Show, Like with Kelly and Michael, Montel Across America and The CBS Early Show. The cornerstone of Dr. Perlmutter’s unique approach to neurological disorders is founded in the principles of preventive medicine. He has brought to the public awareness a rich understanding that challenging brain problems including Alzheimer’s disease, other forms of dementia, depression, and ADHD may very well be prevented with lifestyle changes including a gluten free, low carbohydrate, higher fat diet coupled with aerobic exercise. Resources From The Show  Dr. David Perlmutter's official website Grain Brain by David Perlmutter, MD Brain Maker by David Perlmutter, MD Order Dr. David Perlmutter's latest book, The Grain Brain Whole Life Plan Dr. Perlmutter's YouTube Site Healthy Gut Bacteria – Diversity is the Key by Dr. David Perlmutter An Ideal Breakfast according to Dr. Perlmutter Dr. Oz interview-The 3-Day Plan to Digest Carbs You Want Without Gaining Weight NY Times article: How the Sugar Industry Shifted Blame to Fat Dr. Axe-6 Inulin Fiber Benefits, Uses and Surprising Facts Body Ecology- The 6 Benefits of Monounsaturated Fats (MUFAs) The Fats of Life: Essential Fatty Acids in Health and Disease by Professor Glen D. Lawrence Journal of Medical Association-Mediterranean Diet and Age-Related Cognitive Decline Perfect Supplement's Adaptogen Rhodiola Rosea Different Kinds of Physical Activity Shown to Improve Brain Volume and Cut Alzheimer’s Risk in Half  by  Cyrus A. Raji, MD, PhD Wellness FX 23andMe Promethease The China Study by Thomas Campbell and T. Colin Campbell Changing gut bacteria through diet affects brain function, UCLA study shows The Mind-Gut Connection by Emeran Mayer The Empowering Neurologist – David Perlmutter, MD and Dr. Emeran Mayer Dr. John Cryan on TEDMED What You'll Hear On The Show 1:50  Josh discusses today's show topics and David's biography 3:00  Introduction to David 6:00  What's something fun about Dr. Perlmutter? 6:45  Why did you become a physician neurologist? 12:00  What is your message for Alzheimer's and other brain decline diseases? 14:30  The Grain Brain and Brain Maker books: Learn more about the link between food and the brain. 17:50  Grain Brain Whole Life Plan: What led you to write this book? 20:40  Why is your new book focused on 6 key factors: inflammation, burning fat, bacteria levels, hormones & leptin, genes, and balancing our life 25:00  What are the 3 best sources of fats available? 29:00  Why is inflammation at its highest right now? Can we remove anything from our diets? How can people use your program for wellness? 35:00 What is the Grain Brain Whole Life Plan? How can we make the most out of this plan? 36:50 Perfect Supplement's Adaptogen Rhodiola and the Wellness Bundle Rosea 38:00  The power of exercise for a healthy brain and preventing Alzheimer's disease 41:00  What is APOE and how is it related to Alzheimer's disease? 43:20 Monosaturated fats: What other ways can someone who is prone to Alzheimer's follow a healthy fat diet? 51:25  The link between gut health, food, and depression 56:10  What's the connection between our emotions being created in the gut? Why not the brain? 58:35  How does someone know if they have an issue with a leaky gut? 1:03:30  7 for 7 round with David and Josh 1:06:00  David's message about finding gratitude in life 1:10:00  David's definition of wellness 1:12:10 Takeaways from today's show Rate & Review Wellness Force Aloha! Josh here. Listen, I deeply value your thoughts, now let your voice be heard. I live to serve the Wellness Force even better based on your words, feedback, and requests. (including how these episodes can allow you to break bad habits) Thanks To Our Amazing Sponsor Want to avoid more trips to the store and save hundreds of dollars a year on superfood supplements? Check out Perfect Supplements.com Go to perfectsupplements.com/wellnessforce to get your grass-fed collagen from today's show and sign up for a free membership, plus get 10% off your entire order - just enter promo code "wellnessforce" at checkout.   Ask A Live Question For The Next Episode Click here to leave a voicemail directly to Josh Trent to be read live! Get Your Free Audio Book http://www.wellnessforce.com/FreeBook  You May Also Like These Episodes Food Freedom Forever With Melissa Hartwig Nir Eyal:Breaking Bad Habits, Technology Addiction, & Emotional Triggers Healthy, Happy & Harder To Kill w/ Steph Gaudreau of Stupid Easy Paleo Beyond Meditation: How To Get A Better Brain With Ariel Garten Living A Healthy Lifestyle In A Modern World With Dan Pardi Creating A Life Worth Living With Michael Strasner Get More Wellness In Your Life: Download Your Free Wellness Technology Guide: wellnessforce.com/radio Don't miss next week's show: Subscribe and stay updated Did you like this show? Rate and review Wellness Force on iTunes So nice! You read all the way to the bottom? That's what I call love! I do the same thing for the people, things, and movements I care about as well. PS: Looks like you and I share the same passion. I'm grateful for you and want to extend you my email address. 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The impact of gut bacteria on our cardiovascular system and metabolism has been well-researched. But how about the effect on our minds? Scientists are examining the possibility that these bacteria might influence our moods. John Cryan, who's Professor of Anatomy and Neuroscience at University College Cork, has just published a review of the current state of the field in the journal Genome Medicine. So could we see a day when certain gut bacteria are used in the treatment of depression and anxiety? We brought together John Cryan with Phil Burnett, who's a neuroscientist working with psychiatrists at the University of Oxford. Is the murder rate rising? Think you know what proportion of the population are immigrants or how many people voted in the last election? Ipsos Mori Social Research Institute has been conducting worldwide research to explore how accurate people's perceptions are about the reality of what's happening in their country. They've found we're not terribly good it. Their Global Director Bobby Duffy came into the All in the Mind studio to discuss what's going wrong with our thinking. And we've the latest on the nine finalists in the All in the Mind Awards - the Depressed Cake Shop where the cakes are grey on the outside and bright on the inside, and they're getting people talking about depression in a very unique way. Presented by Claudia Hammond.

Episode 105: Professor John Cryan discusses some of his lab's breakthrough work on the microbiome and how it affects all aspects of the brain, including mood, behaviour, and potentially clinical issues such as autism and anxiety.

On this week's episode of The Microbiome Podcast, we spoke with Dr. John Cryan from University College Cork in Ireland. Dr. Cryan is a world leader in the study of the communication between the gut and the brain and how the microbiome may influence this pathway. We talked all things gut-brain axis with him. Read detailed show notes. 

John F. Cryan is Professor & Chair, Dept. of Anatomy & Neuroscience, University College Cork. He received a B.Sc. (Hons) and PhD from the National University of Ireland, Galway, Ireland. He was a visiting fellow at the Dept Psychiatry, University of Melbourne, Australia (1997-1998), which was followed by postdoctoral fellowships at the University of Pennsylvania, […]