Place in Greece
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4 episodes with ioannina
3 episodes with ioannina
2 episodes with ioannina
2 episodes with ioannina
2 episodes with ioannina
2 episodes with ioannina
2 episodes with ioannina
2 episodes with ioannina
2 episodes with ioannina
A conversation with Emily Neumeier (Temple University) about Ali Pasha of Ioannina (d. 1822), a powerful Ottoman governor of Albanian origin who created a quasi-independent realm at a time when the Ottoman empire was feared to be collapsing. We talk about how he crated his own brand-image, in part by forging closer relations with his Christian Greek subjects and also through archaeological work and use of antiquities. His was an almost post-imperial world, but the nation-state had not yet arrived. We also talk about the concept of the "post-Byzantine," which is used, especially in art history, for works of this period. The conversation is based on three of Emily's articles -- "Mediating Legacies of Empire," "Rivaling Elgin," and "Spoils for the New Pyrrhus" -- that you can find on her academia webpage.
He moved as a young man to Constantinople to work as a craftsman. After the Turkish conquest of Constantinople, many Christians had denied Christ and embraced Islam. John spoke with many of these about the Faith and challenged them for their betrayal of Christ. Shamed and angered, some of them had him arrested, falsely stating that he had earlier accepted Islam and then returned to Christianity, which is punishable by death in Islamic law. He was tortured and cast into prison. When he was brought out for more torture on the day of Pascha, John came forward full of joy and singing 'Christ is risen from the dead!' To his torturers he cried, 'Do what you will to me, and send me as quickly as possible from this transient life into life eternal. I am Christ's servant; I follow Christ, and I die for Christ that I may live with Him.' He has bound in chains and taken to be burned, but when he ran joyfully into the fire, his tormentors pulled him from the flames and beheaded him instead, then threw his head and body into the fire. Christians were able to gather a few of his wonderworking relics and bury them in the Great Church in Constantinople.
In our inaugural episode of Life and Art from FT Weekend, we go to Athens. The FT's Greece and Cyprus correspondent Eleni Varvitsioti is a lifelong Athenian, and for the past 16 years she has lived in the centre of town, in the shadow of the Acropolis. But as Athens has become more popular with tourists, the centre has become less and less livable. This week, Eleni tells us what exactly is causing the congestion, and what should be done about it. She and Lilah also suggest alternate Greek itineraries, from coastal day trips within an easy drive from Athens, to their favourite islands.-------We love hearing from you. Lilah is on Instagram and X @lilahrap. You can email her at lilah.raptopoulos@ft.com. -------Links: – Eleni's essay on living in Athens' city centre: https://on.ft.com/3QJo373Greece recommendations:– From Athens, Eleni suggests you drive 15km-20km along the coast to around Cape Sounio, where there are beautiful beaches. Visit the Temple of Poseidon and visit a taverna underneath it.– Lilah recommends Thessaloniki, Greece's second-largest city, about 500km north of Athens. There are two perfect restaurants for sit-down gyros and soutzoukakia (Greek meatballs): Diagonios and Diavasi.– Eleni suggests, if you're visiting Thessaloniki, to also visit Vergina, which is the tomb of Philip II of Macedon (Philip the Great).– For islands, Eleni recommends Sifnos. Lilah recommends Skopelos, and the much less discovered southern coast of Crete.– Other recommendations that we didn't have space for in the episode: Eleni suggests taking a drive from Athens down along the coastlines of the Peloponnese, or to visit the northwest of the country, Ioannina, if you like nature and hiking. Lilah recommends climbing Mount Olympus, which is an actual thing you can do (you can take day hikes or stay overnight at the peak), and visiting Meteora, a complex of 14th century monasteries built precipitously on the tops of immense towering rocks.-------Special FT subscription offers for Weekend listeners, from 50% off a digital subscription to a $1/£1/€1 trial, are here: http://ft.com/lifeandart.-------Original music by Metaphor Music. Mixing and sound design by Breen Turner and Sam Giovinco. Clip courtesy of Sony Pictures.Read a transcript of this episode on FT.com Hosted on Acast. See acast.com/privacy for more information.
Abrimos el 21 de este año en La Ruleta Rusa con nuestra portada, el nuevo álbum de Elder, Innate Passage, publicado el pasado 2022. Brutal! Después, disfrutaremos con el directo de los griegos Villagers of Ioannina City, esta estupenda banda de rock que en el 2020 grabó este estupendo directo en Atenas, Through Space and Time. Escucharemos también a The Smiths, como recuerdo al bajista de la banda, Andy Rourke, quien tristemente nos ha dejado esta semana pasada. Continue reading La Ruleta Rusa 21.2023. Elder. Villagers of Ioannina City. Recuerdo a Andy Rourke, The Smiths. Triana. at La Ruleta Rusa Radio Rock.
He moved as a young man to Constantinople to work as a craftsman. After the Turkish conquest of Constantinople, many Christians had denied Christ and embraced Islam. John spoke with many of these about the Faith and challenged them for their betrayal of Christ. Shamed and angered, some of them had him arrested, falsely stating that he had earlier accepted Islam and then returned to Christianity, which is punishable by death in Islamic law. He was tortured and cast into prison. When he was brought out for more torture on the day of Pascha, John came forward full of joy and singing 'Christ is risen from the dead!' To his torturers he cried, 'Do what you will to me, and send me as quickly as possible from this transient life into life eternal. I am Christ's servant; I follow Christ, and I die for Christ that I may live with Him.' He has bound in chains and taken to be burned, but when he ran joyfully into the fire, his tormentors pulled him from the flames and beheaded him instead, then threw his head and body into the fire. Christians were able to gather a few of his wonderworking relics and bury them in the Great Church in Constantinople.
In this podcast molecular Biologist Dr Elena Seranova joins us to talk through some of the exciting anti-aging and longevity compounds on the market currently, the research behind them and what they do in the body. We consider what you should think about when deciding to take a supplement what each compound does, it's mechanism of action what aging hallmarks each compounds combats. what senescent cells are and what senolytics do, the importance of methylation we cover Quercetin, Trimethylglycine, Nicotinamide Mononucleotide and Berberine Tune in to get the latest information on this exciting compounds and where the research is headed next. About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur. To learn more about Dr. Elena and her work, visit NMN Bio. Health Optimisation Consulting with Lisa Are you struggling with a health issue and need someone who looks outside the square and someone connected to some of the greatest science and health minds in the world? Then reach out to us at lisa@lisatamati.com, we can jump on a call to see if we are a good fit for you or visit Lisa's Health Consulting If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at lisa@lisatamati.com. Order Lisa's Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. Lisa's Anti-Ageing and Longevity Supplements Lisa's full range of anti-aging, longevity and health optimisation supplements curated by Lisa herself working with some of the best supplement producers in the world. https://shop.lisatamati.com/ NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health Metabolic Health Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Ketone-IQ Get your fuel from ketones. Ketones are nature's superfuel, proven to support energy, focus, endurance, and more. Developed alongside the U.S. military and top universities, Ketone-IQ™ delivers all those benefits in one drink. No caffeine, no sugar—just clean, on-demand energy for superior physical and cognitive performance. You can read about it here and https://shop.lisatamati.com/products/ketone-iq%E2%84%A2?_pos=2&_sid=727714231&_ss=r My ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! You can also connect with Matty on his Website YOUR DNA 360 REPORT + ONE-ON-ONE CONSULTATION Enjoyed This Podcast? If you did, subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can discover the benefits of an infrared sauna. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa
#45 Το συγκρότημα Villagers of Ioannina City διαψεύδει όσους πιστεύουν ότι υπάρχει το δίλλημα ανάμεσα στην ξένη ροκ μουσική και την παραδοσιακή ελληνική μουσική. Μιλάμε με τον κιθαρίστα και ιδρυτή Αλέξη Καραμέτη για την μουσική τους και τα σχέδια τους για την νέα χρονιά. Villagers Of Ioannia City (napalmrecords.com) cosmostaellinika@rbb-online.de Von Angeliki Konti.
Artemis Batis Mirón, hija de Apatichia e Iosif-Pepo Batish, nació en 1928 en Ioannina, una ciudad al noroeste de Grecia que durante dos mil años ha sido el hogar de una comunidad judía muy especial: los judíos romaniotas. Artemis tenía un hermano menor de seis años, Solomon-Makis. En el verano de 1943, los alemanes entraron en Ioannina y unos días después su padre y su abuelo fueron asesinados por un pelotón de fusilamiento en la prisión de Pablo-Mela en Salónica. En la noche del 11 de abril de 1944, Artemis, su madre y su hermano llegaron a Auschwitz. Su madre y su hermano fueron enviados directamente a las cámaras de gas y Artemis, con 15 años, fue seleccionada para trabajos forzados. Sobrevivió a las Marchas de la Muerte y fue liberada en mayo de 1945. Emigró a la tierra de Israel y allí formó su familia. Tiene tres hijos, diez nietos y siete bisnietos. En 2012 encendió la antorcha del recuerdo en la ceremonia de Yad Vashem.
It's typical for athletic performance to decline with age. (And, athletes may experience signs of accelerated aging caused by intense training.) If you're worried about your declining performance, start looking at how you train and what you eat. We may not be able to reverse our chronological age, but we can guide our bodies through the ageing process. Did you know that there are longevity strategies specifically for athletes? These strategies consider long-term performance, health, and muscle growth! In this episode, Dr. Elena Seranova joins us to discuss how ageing can affect our bodies and our athletic performance. She shares her strategies, from supplements to lifestyle changes, that can help athletes combat the effects of ageing. If you're overwhelmed by all of the information out there, remember: you need to build a good foundation first. Start with eating right and sleeping well; from there, you can eventually incorporate Dr. Elena's other recommendations. If you want to learn longevity strategies for athletes and how to improve athletic performance, then this episode is for you! Here are three reasons why you should listen to the full episode: Discover how ageing affects athletic performance and why athletes may experience signs of accelerated ageing. Learn longevity strategies that will support athletic performance and your general health, like how to activate your autophagy pathways. Understand that longevity is a process of building good habits; you can start out by focusing on the basics, like diet and sleep. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, which is all about optimising your fitness, lifestyle, nutrition and mental performance for your particular genes, go to https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, and Run Longer Without Burnout or Injuries Have you struggled to fit training into your busy life? Maybe you don't know where to start, or you have done a few races but struggle with motivation or injuries? Do you want to beat last year's time, or finish at the front of the pack? Do you want to run your first 5-km, or run a 100-miler? Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle? Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. NMN Bio offers pure supplements that are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party-tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of ageing, and is designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility. Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health Metabolic Health Episode Highlights [02:32] Why Athletic Performance Drops as We Age The main cause of athletic performance decline is mitochondrial decline. Mitochondrial decline is linked to senescence cells. Senescence cells stop dividing and do nothing. As we age, we may have 5-20% senescence cells in different tissues. This causes inflammation and causes the mitochondria to function improperly, thus increasing reactive oxygen species within cells. Nuclear DNA is usually packed in histones, which preserve genetic material. However, mitochondrial DNAs lack histones, making it prone to oxidative stress and mutations. As we age, our epigenetic processes become less efficient; it becomes a vicious cycle with more reactive oxygen species and less capacity to deal with them. [08:23] How Else Do Our Bodies Respond to Ageing Ageing declines autophagy, which recycles cellular organelles. When there's nothing to clean up dysfunctional mitochondria, problems with energy generation arise. Athletes who have exercised intensely their whole life will have worn-off tissues and lactic acid buildup. Remember, exercise is good, since we want some level of oxidative stress; however, we don't want more oxidative stress than what our body can cope with. Lisa shares how running ultramarathons accelerated her ageing process, wear and tear, and inflammation. [12:29] How to Support Autophagy and Athletic Performance? Intermittent fasting is when people have a certain feeding window a day. After eating, mTOR switches off and AMPK is activated which allows for autophagy. If you want to build muscle, Dr. Elena recommends eating after exercising so you can activate mTOR which helps with muscle growth. You need to create a cycle going of mTOR and AMPK since autophagy recycles cells back into amino acids, which can help cells build new proteins. Don't create a feeding window that's too narrow; you need to have enough fuel for your body. Eat chicken, meat, and foods rich in amino acids. Make sure you're sleeping properly, as this can affect your muscle growth. [18:30] Supplements to Support Autophagy and Longevity You can also support autophagy through supplements like berberine. Dr. Elena recommends adding supplements to specifically target senescence cells. Senolytics help kill senescence cells while senomorphics modify the senescence cells. Quercetin added with Vitamin C can help kill senescence cells. By itself, quercetin can produce toxic metabolites, so it needs Vitamin C to serve as an antioxidant. She also recommends taking their quercetin product with NAC and acetylcysteine to boost glutathione, a potent antioxidant. Quercetin has many benefits including anti-inflammatory properties, and can be used to combat cardiovascular disease, fight seasonal allergies, and can fight cancer. [26:51] How to Take Quercetin Quercetin can be found naturally in fruits and vegetables like strawberries and onions. If you've never taken compounds for their senescent action before, start by taking quercetin at 500 mg every day. After a month of taking it, check in on how you feel. You can also implement detox protocols with a higher dosage of quercetin(around 2 - 2 ½ grams). If you want to implement this protocol, start with 5 days first. Quercetin can be combined with 500mg of chlorella to boost the detoxifying reaction. People with kidney diseases should consult with a doctor before taking quercetin. [32:43] How NMN Can Help Athletes In addition to mitochondrial decline, athletes can experience loss of endurance and muscle loss as they age. Dr. Elena recommends increasing your fasting window depending on your goals. You want more oxygenation in your tissues to preserve endurance and muscle. Dr. Elena offers an NMN product that can increase both endurance and prevent age-related muscle loss. This can help increase insulin sensitivity, activating longevity genes and DNA repair. [36:37] How to Optimise NMN NMN functions optimally when it's attached to a methyl group. Unfortunately, our body's methylation process also declines with age. NMN should be paired with TMG, as it is a rich methyl donor. When you combine NMN, TMG, and quercetin, you'll optimise your performance and endurance. [39:11] Longevity is Your Biological Age, Not Your Chronological Age Many people over 40 are insulin resistant. Insulin resistance is a gateway to biological decline. You can check your insulin resistance by checking your waist to hip ratio. After the age of 40, it's much easier to experience hormonal dysfunction. We need to make a conscious effort to improve our health. Ageing can cause issues to spiral if left uncontrolled. [42:50] Be Careful With Your Food 80% of adults in the west are insulin resistant. The food industry worsens the condition by offering so many processed carbohydrates. Many people have false ideas about what a healthy diet is. You can't have too many carbohydrates and sugar, even if they're coming from fruits. Cut down on carbohydrates, avoid processed foods, and take good oils. [45:21] Start with the Basics Start with the basics. You don't need to add supplements immediately. Just eat clean and good food. There's no such thing as a universal diet. Taking cold showers in the morning can improve hormonal balance. You can start with just 10 seconds of cold exposure. Manage your stress levels and make sure you move regularly. You don't need to be perfect. [50:47] How Some People Live to 100 There were two hypotheses surrounding centenarians: good habits and the absence of high-risk genes. However, some centenarians were found to have bad habits and mutations for Alzheimer's disease. Centenarians have genes that mitigate risks from bad mutations. They also have low IGF 1 levels. When people are young, IGF 1 can improve muscle and tissue growth, but it can be harmful when people grow older. Centenarians' genetic combination allowed for IGF to decrease as they grow older. Listen to the episode to learn more about how centenarians' hormonal processes are being regulated. Commit to regularly regulating and balancing your hormones. This process starts with clean food, caloric restriction, and exercise. About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur. To learn more about Dr. Elena and her work, visit NMN Bio. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Want to learn more from Dr Dom? Check out our previous episode with her: Episode 238 - Reverse Ageing to Live Longer and Healthier with Dr. Elena Seranova Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer Deep Nutrition: Why Your Genes Need Traditional Food by Catherine Shanahan, M.D. Centenarians, metformin, and longevity | Nir Barzilai, M.D., Episode 204 from the Peter Attia podcast Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health Visit NMN Bio to know more about NMN supplements!
He moved as a young man to Constantinople to work as a craftsman. After the Turkish conquest of Constantinople, many Christians had denied Christ and embraced Islam. John spoke with many of these about the Faith and challenged them for their betrayal of Christ. Shamed and angered, some of them had him arrested, falsely stating that he had earlier accepted Islam and then returned to Christianity, which is punishable by death in Islamic law. He was tortured and cast into prison. When he was brought out for more torture on the day of Pascha, John came forward full of joy and singing 'Christ is risen from the dead!' To his torturers he cried, 'Do what you will to me, and send me as quickly as possible from this transient life into life eternal. I am Christ's servant; I follow Christ, and I die for Christ that I may live with Him.' He has bound in chains and taken to be burned, but when he ran joyfully into the fire, his tormentors pulled him from the flames and beheaded him instead, then threw his head and body into the fire. Christians were able to gather a few of his wonderworking relics and bury them in the Great Church in Constantinople.
No one is exempt from ageing, and with aging comes diseases and sickness. Decreased performance and cell production also occur because of this phenomenon. Lifestyle changes may be inadequate to help your body function properly. Over the past years, longevity science has been evolving, with the emergence of several anti-ageing supplements in the market. However, the body may not absorb these supplements effectively enough to slow down the effects of ageing. In this episode, Dr Elena Seranova explains how the ageing process works. She details how to use supplements, complemented by lifestyle changes, to reverse ageing. She also shares how NMN can be coupled with TMG to create the ultimate longevity supplement. There's no one supplement to optimise your health, but good habits and lifestyle changes are integral to having a longer and healthier life! If you want to learn how to reverse ageing through supplements and lifestyle changes, then this episode is for you! Here are three reasons why you should listen to the full episode: Understand the aging process, its vicious cycle, and how it affects and changes our bodies. Learn how you can slow down and reverse the effects of aging. Discover how you can combine TMG with NMN for better results. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle? Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health Metabolic Health My ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [01:53] How Longevity Science Is Growing There are a growing number of anti-ageing products as we understand the ageing process better. Multiple cellular processes decline or become imbalanced as people age. There are 9 hallmarks of ageing, and the study recently added another hallmark to include inflammation. The top four killer diseases are cancer, cardiovascular disease, neurodegeneration, and diabetes. The older you are, the higher your chance of developing one of these diseases. Our body peaks at 25 and starts the aging process from there. [06:06] Why Is NMN Important? NMN stands for nicotinamide mononucleotide and is a Vitamin B3 derivative. It's a natural molecule that you can get from food, but getting an efficient dosage requires supplementation. NMN is a precursor to help our metabolism, and it boosts NAD levels. NAD serves as fuel for SIRTUIN proteins that are involved in rejuvenation processes. NAD is vital to keep our cells healthy and ensure they don't lose their identity. [09:23] What Happens in the Body as We Age Cell identity is vital. What differentiates cells is how certain parts of the genomes are read. As we age, this process can become chaotic. Chromatin is a substance in a chromosome. Lightly packed chromatin under active transcription is called euchromatin. Heterochromatin, on the other hand, is more condensed and transcriptionally silent. Epigenetic changes can dictate which areas will be active or inactive. This defines how a cell can be expressed. Sirtuins are crucial in making sure the right genes are active and mediating DNA repair. However, they become less efficient as we age. This is how our epigenetic regulation becomes loose, leading to genomic instability and loss of cellular identity. [15:33] How Aging Can Create a Vicious Cycle NAD is the fuel source of sirtuin genes. When these genes are depleted, our DNA can't be repaired. As we age, NAD production depletes. DNA breaks and genome instability also increase. This becomes a vicious cycle of needing more energy but with less production. Furthermore, genome instability can increase senescence or zombie cells. These can further increase genome instability. Senescent cells are cells that forget how to do their function well and stop replicating. These cells can further drain NAD levels. [18:19] The Link Between Fasting and Cell Autophagy Autophagy is the process where cells can get rid of toxins and other things that are not needed anymore. Autophagy ensures housekeeping and can be triggered by fasting. 12 hours of fasting can start autophagy in the liver, while 20 hours of fasting can start the process in other tissues. Eating can activate mTOR, which is another vital cell regulator. This process is deactivated through supplements like Berberine. Learn to balance both eating and fasting. Hear about Dr Elena's fasting schedule and supplements in the full episode! [27:48] Why Dr Elena Launched TMG Methylation is vital for the body's most critical functions. These include creating neurotransmitters, cell division, energy production, metabolism, and epigenetics. Dr Elena launched TMG to boost NMN's effectiveness and metabolism. Methylation and TMG can control homocysteine levels, which correlate with cardiovascular diseases. TMG may also enhance athletic performance. It also has a good safety profile with no side effects despite higher dosage. Dr Elena recommends a 1:2 or 1:3 ratio of NMN to TMG. For every 500 milligrams of NMN, take 1 to 2 grams of TMG. [33:31] Do We Need to Worry about Hyper-methylation? It's difficult to hyper-methylate. However, individual genetic factors can affect homocysteine levels. To check your homocysteine levels, you can undergo a blood test or check your gene variants with a genetic test TMG is an osmoregulator that helps regulate cell balance and can optimize methylation. After taking over 20 grams, a laxative effect may appear. [39:41] Where to Start Dr Elena recommends taking NMN, TMG, and extra virgin olive oil for anti-ageing. NMN can also help increase insulin sensitivity and boost collagen production, as seen in human clinical trial in prediabetic women. The market has a lot of collagen supplements, but not all of them are absorbed by the body effectively. Insulin sensitivity decreases as we age. This is the body's ability to let glucose flow freely into cells. You can reverse ageing problems with a better lifestyle and supplements. Dr Elena recommends avoiding carbohydrates in your diet. [42:55] How to Have a Healthier Diet Around 80% of adults in the West may be pre-diabetic. So many foods nowadays are made to be addictive. While a vegan diet can help you detox at first, you will eventually experience amino acid depletion. Dr Elena prefers a carnivore diet. She also does fasting with a three-hour eating window. You can start with a longer eating window and slowly reduce it. You don't want a glucose spike in the morning. [48:06] You Don't Need to Be Perfect You don't have to be perfect every day, but make sure you stay consistent with your overall longevity routine. Exercise and saunas activate Sirtuins. Try to have a routine for one or both. Optimize your routine and find out what works for you. [50:52] NMN Bio's Growth Dr Elena shares that her company has been growing rapidly. They now have a UK warehouse, UK Amazon FBA, and another warehouse in Europe. They are also expanding to the United States. Remember that no one supplement will do everything for you. You also need to change your lifestyle, which includes diet, exercise, and even biorhythms. There's a lot of information about longevity online, and it can become overwhelming. This is why Dr Elena created an online course about longevity. Dr Elena recommends making sure your circadian rhythm is not disrupted. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Tune in to more Pushing the Limits episodes on health and ageing! Episode 231: The Immune System and How It Fights Cancer Cells and Viruses with Dr Elizabeth Yurth Episode 196: Rethinking the Function of Mitochondria for Our Health with Dr Elizabeth Yurth Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Episode 187: Back to Basics: Slow Down Ageing and Promote Longevity with Dr Elizabeth Yurth Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer The Ultimate Anti-Aging Combination: TMG & NMN to Live Significantly Longer? By NMN Bio The Hallmarks of Aging Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women Visit NMN Bio to know more about NMN supplements! Lifespan by Dr David Sinclair 7 Powerful Quotes [04:28] ‘The older you are, the highest your risk of getting one of these diseases; so if it's not gonna be one of them, it's gonna be the other one… Now we start realising when does aging start, which is actually at quite a young age, basically at the age of 25. Because this is where our hormones peak…' [12:25] ‘There are multiple functions that Sirtuins need to attend to within the cell. With age, this function becomes less and less efficient, basically, because sirtuins become more forgetful.' [16:02] ‘So as we age, the production of NAD is declining. So this means that there is less NAD available for sirtuins to use as their fuel to do their job.' [39:52] ‘There are so many collagen supplements on the market, but not all of them are efficient. And actually not all of them are being absorbed properly because when you do take collagen orally, basically, it's broken down into amino acids in your digestive system. And then those amino acids may or may not be used to produce more collagen.' [47:56] ‘We're all on this road of re-educating ourselves and don't go for perfection. Just go for better, I think is a message as well, you don't have to be perfect.' [52:22] ‘With regards to the longevity field, I think that it's very important for people to understand that there is no such thing as the fountain of youth. There is no one supplement that you're going to take that is going to do everything for you.' [56:40] ‘If your melatonin is disrupted, then you will have less defense against reactive oxygen species and that there is another plethora of processes that melatonin is also implicated in and then you don't have all these benefits. And then you're basically aging faster… Takeaway message from today's podcasts. Make sure that you go to sleep early, everyone.' About Dr Elena Dr Elena Seranova is a scientist, serial entrepreneur and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr Elena then started a private practice before developing an interest in neuroscience. She continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr Elena's expertise in these fields has led her to become the co-founder of a biotech start-up, SkyLab Bio. She has written several peer-reviewed articles on autophagy throughout her career. In addition to these accomplishments, she started her latest business, NMN Bio. Her own experiences with the use of supplements have inspired her to expand the market to supply the public with cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur. To learn more about Dr Elena and her work, visit NMN Bio. Enjoy The Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa
Expert: Nicholas Pavlidis, University of Ioannina, Ioannina, Greece
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Viele Fachkräfte haben Griechenland verlassen. Eine Tech-Offensive für ausländische IT-Firmen soll sie zurück locken. Spätestens die Corona-Krise hat deutlich gemacht: Die griechische Wirtschaft ist zu einseitig auf den Tourismus ausgerichtet. Deswegen setzt die Regierung unter Ministerpräsident Kyriakos Mitsotakis jetzt verstärkt auf die Tech-Industrie. Die Idee: Griechenland soll attraktiver Standort für ausländische IT-Firmen werden. Mit den Unternehmen - so das Kalkül der Regierung - werden auch wieder jene Fachkräfte nach Griechenland zurückkehren, die wegen der Finanzkrise ins Ausland abgewandert sind. US-Giganten wie Amazon und Microsoft haben bereits angekündigt, in Griechenland investieren zu wollen. So will Microsoft eine Milliarde Dollar in den Aufbau von drei Datenzentren seiner Cloud-Computing-Plattform Azure stecken. Die deutsche Firma Teamviewer ist bereits in Griechenland aktiv, allerdings nicht in Athen oder Thessaloniki, sondern in Ioannina. Die Stadt befindet sich in einer Region, die bislang eher für unberührte Natur und Käseerzeugnisse bekannt war. Doch genau hier plant die griechische Regierung ein kleines Silicon Valley.
Dr Alfred Vincent will give an online lecture titled "Language, Poetry and a Hot Air Balloon: Ioannis Vilaras and Ioannina in the time of Ali Pasha", s part of the Greek History and Culture Seminars, offered by the Greek Community of Melbourne and Victoria. - «Γλώσσα, ποίηση και ένα αερόστατο: ο Ιωάννης Βηλαράς και τα Ιωάννινα τον καιρό του Αλή Πασά», είναι το θέμα που θα αναπτύξει ο Δρ. Άλφρεντ Βίνσεντ την προσεχή Πέμπτη, 9 Σεπτεμβρίου.
Expert: Nicholas Pavlidis, University of Ioannina, Ioannina, Greece Questions: 1-What do we know about CUP? 2-What do we know about the impact of genomic analysis in CUP diagnosis and treatment? 3-What standard diagnostic work-up is recommended to have completed, before a case can be called a CUP case? 4-Does speeding up the diagnostic process help patients' outcome? 5-How doctors transfer the bad news about CUP diagnosis and outcome to the patients? Does support with palliative care helps CUP patients?
From our physical appearance to our body's mechanical functions, our whole being is encoded into our genes and kept in each cell that makes us. These basic biological units have their system to keep everything functioning and our body alive and moving. They have housekeeping functions: cells perform autophagy to get rid of accumulated waste materials. Maximising the effects of these processes can help in increasing your longevity. When the autophagic processes fail, it can damage important parts of the cell such as the DNA and accelerate ageing. In this episode, Dr Elena Seranova explains the science behind autophagy and how it connects to NAD and sirtuin genes. She also shares her own experience and research on using this knowledge to live a longer, fuller life. Join us in this episode to learn more about autophagy and how this process is useful in increasing your longevity and giving you a boost in life. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health program that is all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to https://www.lisatamati.com/page/epigenetics-and-health-coaching/. You can also join our free live webinar on epigenetics. Online Coaching for Runners Go to www.runninghotcoaching.com for our online run training coaching. Consult with Me If you would like to work with me one to one on anything from your mindset, to head injuries, to biohacking your health, to optimal performance or executive coaching, please book a consultation here: https://shop.lisatamati.com/collections/consultations. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research, and incredible tenacity to prove them wrong and bring my mother back to full health within 3 years. Get your copy here: http://relentlessbook.lisatamati.com/ For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Here are three reasons why you should listen to the full episode: Discover how cells stay healthy. Find out Dr Elena's tips and advice in increasing your longevity by activating autophagy. Learn more about the science behind NMN supplements and their revitalising effect. Resources Read about Dave Asprey’s work around the keto diet. Lifespan by Dr David Sinclair Pushing the Limits Ep 170: The Search for the Perfect Protein with Dr David Minkoff Visit NMNBio if you want to learn more about NMN supplements in New Zealand. Episode Highlights [04:33] Getting to Know Dr Elena Seranova Dr Elena Seranova is an interdisciplinary scientist. She holds a degree in Psychology, MSc Translational Neuroscience, and a PhD focusing on autophagy and cell biology. With her expertise in her field, she co-founded a biotech startup and is now the the founder of NMN Bio in the United Kingdom. [06:06] What Is Autophagy? Autophagy is a catabolic pathway that degrades unwanted materials within the cell. The cell needs to avoid the build-up of unnecessary materials. There are different pathways for activation like mTOR (mammalian target of rapamycin) and PI3K (Phosphoinositide 3-kinase). Impairments at various stages of autophagy lead to its failure and cell death. Once autophagy fails, apoptosis, or programmed cell death, can activate. [11:25] NAD as Fuel for Sirtuin and PARP PARP and sirtuin are different classes of enzymes that use NAD for multiple vital processes, including DNA repair (both) and gene expression (sirtuin). Sirtuin 1 is one of the pathways that can initiate autophagy. initiates the autophagic process. When DNA is damaged, PARP activates and depletes NAD stores. The decrease in NAD levels inhibits sirtuin's ability to carry out its functions, including autophagy, accelerating a cell's death. [15:34] What Is NAD? Nicotinamide adenine dinucleotide or NAD is a substrate for enzymes. It plays a vital role in different reactions within the cell. You can supplement NAD levels using boosters such as nicotinamide mononucleotide (NMN). [18:44] mTOR-Independent Pathways Activation of autophagy using Sirtuin 1 is an mTOR-independent pathway. It is essential not to activate autophagy through mTOR pathways. mTOR is responsible for cell growth and translation. [25:04] How to Activate mTOR-Independent Autophagy Autophagy is dependent on nutrient starvation. Intermittent fasting can activate it. A generally healthy lifestyle includes supplement intake, proper sleep, and healthy foods. Avoid too much sunlight because it damages the skin and DNA. It activates PARP enzymes. Take a tablespoon of extra virgin olive oil which contains oleic acid. This good fat has the same effects as resveratrol. Induce artificial stress through cryotherapy, saunas, and exercise to activate sirtuin 1. [33:22] Why Did Dr Elena Decide to Bring NMN to the Market? She came across NAD and NMN during her doctorate studies and saw their importance. Her own experiences showed better focus and energy levels after taking NMN supplements. There are not enough reliable suppliers that offer good regulation and quality control. She wanted to provide the best for herself and her family. NMN Bio has complete transparency on suppliers and quality regulation [38:28] Can Weight Loss Occur from Taking NMN? Lisa Tamati's experience in taking NMN shows fat loss but no muscle loss. Dr Elena's mice studies show evidence that NMN can improve insulin sensitivity and lipid metabolism. [40:42] Do NMN Supplements Have Any Downsides? They found no side effects in studies with mice despite an increase in dosage. Current studies are still ongoing to determine the ideal dosage for humans. Most people take 500mg to 1g. Doubling this still shows good tolerance. Take supplements in the morning as NAD affects the circadian rhythm. [53:57] How Do Autophagy, NAD and Sirtuin Genes Fit Together? Autophagy recycles various damaged organelles. Sirtuin 1 genes activate autophagy and mitophagy. NAD functions as a substrate for sirtuin enzymes to work. NMN supplements can increase NAD levels. Listen to the episode for the full explanation of how these three work together. [58:43] Can NMN be Taken as an Infusion? This is not something that Dr Elena has studied in-depth and she is curious as well about how viable this procedure will be. There is a low concentration of energy in intravenous injections, but it's present. Oral administration is more reliable in giving boosts and it costs cheaper. [01:00:01] Do Antioxidants Help in Increasing Your Longevity? Studies have shown that antioxidants don't suppress ageing. Lifestyle intervention and autophagy activation are proven ways to slow ageing. 7 Powerful Quotes ‘Lysosome is another acidic organelle that contains acid hydrolases that are able to digest this cargo...and if it doesn't work, well, the cell is basically in trouble because you have all this garbage floating around, and there is nothing to remove them. So this is why autophagy is important. ‘When things are preserved across species, then that gives a scientist an indication that this is probably a very important biological function’. ‘I think that in order for your body to function properly, you really need to have a kind of a healthy routine in general’. ‘So I think that when it comes to being healthy, and activating your autophagy levels, and having a healthy lifestyle in general, you need to start with the basics first.’ ‘Another small tip that I can give is to actually avoid sunlight, which is something that people don't really consider. What happens when we're exposed to sunlight, when our skin is exposed to sunlight for prolonged periods of time, we start getting the DNA damage’. “The important part is not to just increase your age, it’s to increase your healthspan.” ‘And if you have if your mitochondria are not healthy, and they're dying, and you're not having enough mitochondria in your cells, then you are going to be sick.’ About Dr Elena Seranova Dr Elena Seranova is a scientist, serial entrepreneur and business mentor who has founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. She started a private practice before developing an interest in neuroscience. She continued her studies and earned her Master’s Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Her expertise in these fields has led her to become the co-founder of a biotech start-up, SkyLab Bio. She has written a number of peer-reviewed articles and multiple research articles on autophagy throughout her career. Aside from these accomplishments, she started her own business, NMN Bio. Her own experiences with the use of supplements have inspired her to expand the market to supply the public with cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, UK, and Europe. Dr Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur. To learn more about Dr Elena and her work, visit her website. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends, especially those interested in increasing their longevity, so that they can practice the activation of autophagy in their lifestyle. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa Transcript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential, with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Well, hi everyone and welcome back to Pushing the Limits. This week I have Dr. Elena Seranova, who has already been a guest on the show. And today, we're talking about autophagy and NAD, and the interplay between these two. Now that might sound extremely boring, but it isn't. It's all about longevity and anti-aging. So, we're going to be talking about the science between about NAD precursors and the sirtuin genes, and how to upregulate the sirtuin genes, and all about autophagy, which is really the recycling of old and damaged parts and proteins of a cell that need to be gotten rid of. So, it's a bit like having a good garbage disposal unit happening. And there are many ways to activate autophagy, which we go into in this episode. We talk about intermittent fasting, we talk about cold and hot and hormetic stressors like exercise and yes, of course fasting. But also, mTOR independent pathways to activate autophagy, it'll all be revealed in this interview. Now this does get a little bit technical in the first 20 minutes or so. But hang in there and listen to this a couple of times. Because if you want to slow down aging, if you want to slow down the generative decline of your body and you want to have a long and healthy lifestyle, then this stuff is really, really worth paying attention to and trying to understand. We talk about NMN, which is nicotinamide mononucleotide, which is a supplement that is now available, is a longevity compound to upregulate the sirtuin genes. And we're really lucky to check that out. You can go and find that supplement, which has been made and produced by Dr. Elena Seranova and her company, NMN Bio. So if you head hop over to nmnbio.nz, we're now importing this into the country. So, this is one way that you can really fight aging and degenerative decline that we all fear and don't want. And when you listen to this episode and really listen to it a couple of times, you'll understand some of the incredible anti-aging things that are coming down. This is not pseudoscience. Dr. Elena is one of the most amazing neuroscientists out there. So please listen to this episode, enjoy it, get a lot out of it and get the takeaway. So, if you don't understand some of the terminology, don't worry, keep going. And by the end, you'll start to pick up certain bits and pieces. And if you listen to it again, you'll be able to pick up a little bit more and a little bit more. And at the end of the day, it's about the takeaways, what can you do to slow aging down and all that information is in there. So, I hope you enjoy this episode with Dr. Elena. Before we go over to that we are all about health optimisation, high performance, athletic performance. So, if you need any help with any of those areas of your life, please reach out to us, Support at lisatamati.com. Go and check out our website, lisatamati.com. You'll find all our programs, our Epigenetics Programs, our online run training system that's customised and personalised totally to you, and check out what we do. We love helping you be the best version of yourself that you can be. Now over to the show with Dr. Elena Servanova. Lisa: Well, hi everyone. Lisa Tamati here and very excited to have you hopefully join us this morning. It's 7:30am in the morning here in New Zealand. And where Dr. Elena Seranova is, it's very late at night. How are you doing, Dr. Elena? Dr Elena Seranova: Good, good. How are you? Happy to be here again. Lisa: Yeah, very excited for today's topic. So, we're going to be doing a discussion around autophagy and NAD boosters and sirtuin genes. So it’s going to be a really interesting discussion that is really beneficial for you if you want to know how to live longer, live healthier, and optimise your body and your mind and your potential. So, Dr. Elena, can you just tell us briefly a little bit about yourself? Dr Elena: Sure. So, I started my journey as a psychologist. So I'm an interdisciplinary scientist. I majored in psychology at first and then I had my own private practise for five years which turned out to be a successful wellness centre. And I really got fascinated by neuroscience and the brain. And for this reason, at first I started studying the brain myself and then I found an amazing master's degree at the University of Sheffield in Translational Neuroscience, which basically combined the research and neurodegeneration with applications that could translate into therapeutics. So, this is what translational neuroscience means, is basically the combination and the outcome of the research—the hardcore biology research that can be utilised for therapeutic approaches and patients. I really enjoyed that. So that was quite cool, being in the lab and doing molecular biology experiments and so on. So, I kind of fell in love with the lab, and I decided to do a PhD as well. I continued my studies in autophagy and stem cell biology and it was quite challenging, but at the same time, I really enjoyed it. And I can definitely say that science is a big part of my life. Lisa: Definitely your thing. Okay, so autophagy and stem cells. So in relation to neurodegenerative diseases in that case? Okay, but what is autophagy? Because a lot of people will be listening to it and go, ‘What the heck is that big word, autophagy’? It's sort of big word in biohacking circles, but perhaps not in the general public. Can you explain what autophagy is exactly? Dr Elena: Yes, sure. So, autophagy is a catabolic pathway that degrades dysfunctional organelles in the cell or protein pro aggregates. So, any material that is basically unwanted in the cell, autophagy can degrade. It's like the stomach of the cell. Lisa: So, it’s like eating it? It's eating, sort of... Dr Elena: Yeah, exactly. And what happens when autophagy is activated, we actually have the formation of the so-called phagophore, which is a membrane structure that basically engulfs different organelles and materials that need to be degraded to form the so called autophagosome, which is a round organelle that basically has this cargo that needs to be digested. That eventually fuses with lysosome. And lysosome is another acidic organelle that contains acidic hydrolases that are able to digest this cargo. And this process is very essential for the cell, it’s very vital. It's evolutionary conserved in all species, from yeast to models. And if it doesn't work well, the cell is basically in trouble because you have all this garbage... Lisa: Floating around. Dr Elena: ...floating around and there is nothing to remove them. So, this is why autophagy is important. And we have different pathways that autophagy can be activated through as well. So, one of those pathways is mTOR, mechanistic target of rapamycin. And then we have other pathways that can activate this process such as AMPK, GSK3, and so on. Lisa: So is this like, sorry to interrupt, but like because I know that people out there might be like, ‘Wow, that's a lot of big words and a lot of information’. So, is it like that the cell has to do a housecleaning, and it's got stuff inside the cell that is not working optimally, and needs to be gotten rid of, or is it the whole cell? So, it's not apoptosis. So it's not where the host is disintegrating? Dr Elena: No. Yeah, it's actually a—it's a pre-apoptotic pathway. So, before apoptosis is activated, we have autophagy. And if autophagy fails in what it needs to do, then we have activation of some apoptotic pathways. So, it's one step before that. And if everything goes well, and autophagy is functional—and by the way, in different diseases, we might be having different autophagy impairments at different stages of autophagy. So, it's either the initial phagophore formation, for instance, that it's not working well, and it can’t engulf the cargo, or it's insulator stages of autophagy, such as the acidic hydrolysis and the lysosomes that are actually not that acidic. So their pH is not acidic enough to digest the cargo. So, we might be having different defects in the autophagy pathway in different diseases. Lisa: That leads to apoptosis. Am I right? Dr Elena: And yeah, if autophagy is not doing its work correctly, then eventually we will have apoptosis. And actually, this is what we're seeing in in vitro models of neurodegenerative diseases as well. So, for instance, if autophagy is not working well. And we have, let's say, dysfunctional organelles, such as mitochondria—dysfunctional mitochondria that are not working well. Let's say they are depolarised. And there is an excess production of reactive oxygen species going on. Now, if nothing can degrade these dysfunctional mitochondria, you'll keep on having this accumulation of reactive oxygen species, which eventually will lead to DNA damage and deactivation of PARPs. And it's basically a death spiral that will keep on leading the cell towards death. Lisa: Okay, so what is a PARP? You mentioned PARP there. And just for the listeners, too. So, apoptosis is basically cell death, programmed cell death. So, this is not—what's the other one necrotic or something? Dr Elena: Necrosis? Lisa: Yeah, necrosis, where the cell dies for—necrosis. But this is sort of a natural programmed cell death. But we only want that if we're actually renewing the cells and we are wanting new stuff. So, before that, the body tries to do this autophagy process, is that how it works? And then what so what is PARP? What is PARP, because that’s the word again... Dr Elena: PARPs are a class of enzymes, and in order for them to function, they need a molecule called NAD, so nicotinamide adenine dinucleotide. And they're actually competing for NAD in the cell. And whenever we have increased DNA damage, we would have the PARP activation as well. And this would lead to NAD depletion, which kind of brings me to my next point about what other enzymes consume NAD. And one of those enzymes are sirtuins, which are the so-called longevity genes that are basically responsible for multiple processes in the cell, including epigenetic regulation of gene expression. So, they do—because sirtuins are a class of enzymes that are also dependent on NAD, and they're all the deacetylase enzymes, meaning that they remove acetyl groups from the DNA. And as a result, they control which genes will be expressed in which tissues, which is very crucial for the cellular identity and for the proper function of different cells. So, sirtuins in a healthy cell, so sirtuin should be upregulated and they should be having this housekeeping gene—housekeeping function where they basically control what's going on with the DNA repair and also with the gene expression as well. And if we do have—when we do start having impaired autophagy, and let's say there is increased reactive oxygen species, because there are increased dysfunctional mitochondria in the cell, you will have in more activation of PARPs, and all of the NAD will start being drained from... And sirtuin will not have enough energy to function. So, those are actually quite an elegant interplay between autophagy and NAD and sirtuins. Lisa: Okay. Okay, can I just want to like put that back to you, so that we can slow down because we are going technical quite fast. And I think a lot of people might be like, ‘What the heck are they talking about’? So, the sirtuin genes, basically longevity genes, and then one of the jobs is DNA repair. And another of the jobs is to say which genes are actually being activated right now. And these sirtuin genes are also responsible, I think, for cell replication, is that correct? Dr Elena: The sirtuins are responsible for multiple functions, directly or indirectly. So, for instance, the sirtuin 3 gene is also responsible for mitochondrial biogenesis. And it's implicated in the amount of mitochondria that are being produced by the cell, which is related to cell replication eventually, because you do need to have enough ATP levels to replicate. Lisa: Right. Yeah. So, this has definitely to do with ATP production as well and mitochondrial health. So, these are doing all of these jobs, the sirtuin genes, they're very, very crucial genes in our genome. And these are preserved across every species, I believe? Every species on the planet? Dr Elena: Yeah. Also from yeast to humans, it's also—sirtuin genes are preserved very well. Lisa: And when things are preserved across species, then that gives a scientist an indication that this is probably a very important biological function and we need to have a look at this one because it's—from what I understand. Okay, so when you have activated PARP because you're not doing autophagy well and there's things going wrong, it's taking the NAD. So NAD is basically like a fuel source that both the sirtuin genes. And when PARP is activated, it's using to fuel its job. And so, this is competition for competing fuel sources. So, like if you imagine, you've only got one tank of fuel for your car, but you've got to go in two different directions and do two different jobs. You go, ‘How am I going to divide up my energy’? So, then it becomes important as to how much NAD we have in the body? So, what is NAD again? That says nicotinamide adenine dinucleotide? But what is that and how does it work? Dr Elena: Yeah, it does serve as a substrate for all of these enzymes, including sirtuins and PARPS and is basically a master regulator of metabolism. So, it's a very important molecule and it serves as—without NAD, the cell is not able to function properly just because this crucial molecule is implicated in so many different reactions. So, NAD is found in all living cells and organisms. This is also evolutionary conserved across species. And it exists in two forms, NADH and NAD+, which is the reduced and the oxidised form, respectively. And both of them are important. And both of them are implicated in multiple cellular reactions. Lisa: Is it going backwards and forwards in a cycle, NADH, NAD+, by donating electrons back and forth, sort of thing? Dr Elena: Yeah. Through electron transport chain in the mitochondria, yeah. So, this is why it's so important. And so, what we're seeing now in the latest advancements in longevity research is that we actually can supplement with different precursors of NAD, such as nicotinamide mononucleotide, for instance, NMN. And this is the supplement that my company... Lisa: See, you've now got that available on the market because this is such a crucial thing. Dr Elena: Exactly. And I think that it's really interesting to also say that when it comes to the interaction between autophagy and sirtuins, there is also another regulation of autophagy there. So sirtuin 1 is actually responsible for activating some transcription factors such as TFEB and FoxO3 that have to do with initiation of the autophagy process. So, for this reason, when we do have dropping levels of NAD, decreasing levels of NAD, and there is not enough NAD for sirtuins to do their job. And let's say again—let's talk about that previous example in neurodegeneration when you have increased reactive oxygen species, and you have increased the level of stress and oxidative stress and decreased activity of sirtuins. And not only the situation is already bad, but because sirtuin 1 doesn't have enough energy to function and to activate the TFEB and the FoxO3 transcription factors to initiate autophagy, now you have all of this dysfunctional mitochondria floating around and autophagy starts being impaired as well because we activated enough. So, it's a negative feedback loop which actually accelerates the scenario where the cell is going towards cell death, basically. Lisa: So that means like, if you don't have enough NAD, then your sirtuin 1 gene is not going to be able to initiate autophagy and clean up the cell and you're going to have dysfunctional mitochondria. Is that independent of the mTOR pathway? Or is that—am I getting confused? Dr Elena: So, okay. So, good question. So, what happens is there are some molecules that activates sirtuins. So, for instance, sirtuin 1 is activated by resveratrol, and this is something that has been demonstrated many years ago. So, when you have sirtuin 1 dependent activation of autophagy, you will be having it through an mTOR independent pathway. Lisa: So it's a fasting mimetic resveratrol. Dr Elena: Yeah, yeah. Yeah, absolutely. So, because we now know that the mTOR activity is not affected by intake of resveratrol. And this is quite crucial because actually, even if we want to activate autophagy, we shouldn’t do it through the mTOR pathway, this is not the preferred way, because mTOR is also responsible for growth and translation in the cell. So, this is not—it's also quite a key player in the cell. So it's a serine threonine kinase, and you actually don't want it to be activated at all times because this may lead other conditions. So, what we're focusing on at the moment is to find molecules that can activate autophagy in an mTOR independent manner. Lisa: Okay, so. So if the mTOR—cause MTOR is usually what's for growth it’s anabolic, it's causing growth. So for example, a bodybuilder goes to the gym, they're in an anabolic state, they are in an mTOR growth state. And when you have autophagy, that's sort of the opposite. So, it's a catabolic state where it's starting to eat itself. So, it’s mTOR, most people like do fasting for that reason to activate autophagy? Dr Elena: Yeah, this is another good point there. So, when we're fasting, and there is actually conflicting evidence out there as to when autophagy is fully activated. Usually, people say that around 24 hours, you start having the autophagy activation. There are others that swear by the ketogenic diet, and say that if you don't consume any carbs, you will get autophagy activation anyway. However, from what other researchers have found is that, if you are in a ketogenic diet, and you do consume meat, it depends on what kind of meat you consume that will either activate autophagy or not. And it all has to do with levels of different amino acids in the cell because autophagy is quite sensitive to nutrients and to nutrient starvation to be activated. If you have an abundance of amino acids, again, it will not be activated. So, for instance, one amino acid that activates autophagy very well is leucine. And if you're eating certain meat that are rich in leucine, this is probably not good for your autophagic state. Something else to keep in mind, and I've heard, I think it was Dave Asprey saying that if you can manage to be on under 15 grams of protein per day, you will probably keep the autophagy going. Lisa: Because a lot of people on keto think I can eat a lot of protein, which is a mistake, really. It isn't about having—that's interesting, because I had Dr. David Minkoff on my podcast, Pushing the Limits a while ago, and he has a product called PerfectAmino, which is really a 99% usable form of amino acids and combination. And I was interested, ‘Well hang on, if I'm heading there, which is going a lot of good things in the body. But is that going to inhibit my mTOR, or autophagy’? Sorry, because I've got too much leucine in there? Dr Elena: This is a very good point for all of this process food as well. So, for instance, there are some ready meals you can get or some protein bars that claim to have all the low carb and everything. And then they slam a badge on their pack saying that it's vegan as well. But then, why is it vegan if it has all the amino acids because that's one of the selling points when you're actually on a vegan diet, or you have some days where you are on a vegan diet. You want to get yourself in a state of partial amino acid depletion to get this beneficial effect of enhanced autophagy. And on intercellular toxins and so on. Lisa: Right, so for certain periods of time, you want to do this, and it's a cycling thing, you don't want to be completely deficient of aminos for too long because then your body will start to break down. Dr Elena: This is what I do personally as well. So, during the week, so I am a fan of cattle/carnivore diet. So, this diet is quite comfortable for me and I enjoyed it quite a lot. But then during my week I try to have some days where I'm either vegetarian or vegan, just because I want to have those benefits. Lisa: Yeah. Up and down. And then this seems to be a theme in biology all the time is that it's not one thing. It's not staying on keto for ever and ever, amen. It's about doing cyclic keto or cyclic vegan and it’s cyclic. And our body loves this push and pull—when there’s recovery and there’s growth and then clean up phase, growth clean up. So autophagy can be activated through fasting. It can also be active through having resveratrol and upregulating the sirtuin 1 gene, how else can we activate autophagy? Dr Elena: So there are different ways, there are different things you can really implement in order to activate autophagy. And I think that it all has to do with how you build your lifestyle in general. So, I think that in order for your body to function properly, you really need to have a kind of a healthy routine in general. And an analogy that I can give you there is that there are people that would buy a couple of supplements, and then they would be so proud of it. And then they would say, ‘Oh, yeah, but I'm taking those supplements now, and I'm so healthy’. And then their biorhythms are all off. They sleep at 5am every day. And they're eating crappy foods or super processed foods. Lisa: Yeah, it’s not going to work. Dr Elena: It’s all good. So, I think that when it comes to being healthy and activating your autophagy levels and having a healthy lifestyle in general, you need to start with the basics first. So, the intermittent fasting is definitely the first step to take in order to become a bit healthier. And from the research that I'm reading, and from the things that I'm implementing, I definitely believe that both anecdotal and scientific evidence point towards the fact that intermittent fasting is actually the way to go. I mean, there are conflicting opinions out there and there are pros and cons in every diet, and so on. And I get that. But I personally believe that with intermittent fasting, if you try to narrow down the window where you're uptaking food, this is very, very good for you. So, this is step number one. But then again, so either you're trying to raise your NAD levels, or you're trying to activate your autophagy, because those pathways are quite intertwined. And what you eventually want to do is you want to have increased levels of sirtuin, and sirtuin 1 in particular, and sirtuin 3, of course, and so on. And for this reason, in order to preserve this pool of NAD that is available for the sirtuin 1 to activate itself and activate the autophagy pathway. Another small tip that I can give is to actually avoid sunlight, which is something that people don't really consider. But what happens when we're exposed to sunlight, when our skin is exposed to sunlight for prolonged periods of time, we start getting the DNA damage. And when you get the DNA damage, you have PARP activation, and then again, you NAD pool... Lisa: Wow. I never connected those dots. That's really interesting. So, because—I mean, we need sun. We need sun for vitamin D and for our mood and all that sort of stuff. So, you're not saying don't have any sun. Dr Elena: Yeah, sure. Lisa: But because the sun is causing DNA damage, it's going to cause more PARP activation, it’s going to have the sirtuin genes going to repair the DNA, that's going to use up the body's resources is what you're saying. Okay, wow, that makes sense. Makes sense. And then by the same token, like things like smoking that breaks DNA, like no tomorrow. This is why smoking ages you is because of all the DNA breaks. And this is why, when you're in the sun for hours every day, you get wrinkly skin and you get collagen lost and all the rest of the things that are happening. So, anything that's going to be causing DNA breaks is going to cause you to age quicker. Dr Elena: Exactly. Lisa: Using up the resources basically. Wow, okay. Dr Elena: So it's obviously—you don't have to become a vampire and dissipate walk in the sun when you want to go somewhere. But sunbathing for hours is definitely not something you want to do with—to get your body go through, basically. So that's another tip. And then something else, really, really simple that can be implemented on a daily basis in order to maintain your sirtuin levels, and as a result, your autophagy levels, and your NAD levels is also to take a tablespoon of extra virgin olive oil, which contains oleic acid. And it basically does the same job as resveratrol. And it's interesting—I think that there's been a recent research article out that shows that like oleic acid might even be more efficient than resveratrol, in terms of activating sirtuin 1, which I think it's really, really cool. Lisa: So yeah. Well, combine the two. I do. Dr Elena: Yeah, absolutely. You can do that. And then, you need to make sure that the extra virgin olive oil is actually of a very good quality because there is a bunch of... Lisa: There is a bunch of rubbish out there. So, make sure it's from an orchard that you know, it's cold pressed, it's all those extra virgin, it's all that sort of good stuff. And not—how do they do it with solvents and stuff? Or that it's come from multiple orchards and being cut with other oils. It's a really, really important point. And then oleic acid does so much good things in the body. But isn’t that fat, Elena? Like lots of people are like, in their minds are going, ‘But oil is fat. It’s the same with MCT oil. Isn’t that going to make you fat when you eat fat’? Just going to put that around. Dr Elena: There are good fats and there are bad fats. So, olive oil is good fat. MCT oil is a good fat. Avocado is a good fat. So, not all thoughts are made equal. So, this is definitely something important to keep in mind, especially with a good quality extra virgin olive oil. Lisa: Because each one of our cells is a membrane that has a phospholipid, isn't it? So we need that, actually, this building of ourselves into the integrity. Dr Elena: We have a phospholipid layer in the brain as well. And this is why we actually supplement with omega 3 fatty acids, because this is what it does. So, this is what omega 3 fatty acids do. They go into the phospholipid membrane, and then they basically... Lisa: Make the integrity of that membrane better. Dr Elena: Yeah, they contribute to the healthy phospholipid layer in the brain. Lisa: So that's why it's very important for neurodegeneration to have omega 3s going in and again, people get quality omega 3s. Not your cheap supermarket ones that are perhaps oxidised and have been sitting on the shelves for six months. So really important to get a reputable source here. And omega 3 is of course in fishes as well, and krill, and so on. Okay, so but is there a downside to fat? Because I studied epigenetics and a lot of people's profiles come back with don't have too many fats. And it's been one of those things in my head is like ‘Why would some people not come back with you shouldn't have too much fat’? I mean, there are things like gall bladders been removed. That's a pretty specific thing. But is there a genetic component? And probably not your wheelhouse, really, but is there a genetic component to your ability to process fat? Dr Elena: There is a genetic component, and I've actually seen this with a family that has a history of very problematic digestion of fat, and so on. Absolutely. But yeah, again, not all fats are made the same. And when you cut off the bad fats from your life, things change and everything changes really. Lisa: Yeah, it really is very satiating, too to have a little bit of fat and that can really help with cravings and blood sugar spikes—we're getting off topic. So you have a company, NMN Bio, which produces nicotinamide mononucleotide supplement. And you've got a whole range of other stuff coming as well. Why did you decide like, you need to get this out there on the market? Based on your research and your knowledge around this area, why is it important that people take NMN if they're serious about slowing aging? Dr Elena: So first of all, I came across the biology of NAD and NMN during my PhD studies and my research kind of led me into this field because I was studying autophagy neurodegeneration. And actually, I still cannot disclose my research. Lisa: Yeah, it’s not published yet. Dr Elena: My research paper from my PhD is not published yet, but hopefully soon, so we're about to submit it quite soon actually. So for this reason, I started studying the biology of NAD and I actually saw how important and how crucial NAD is to the cell and what happens when we have a lack of NAD and depletion of NAD pools in the cell. And I've been supplementing with different kinds of vitamins and supplements my whole life really. So, I was watching closely this space for a while, and I was taking different supplements myself for a while. And so, when I came across NMN and I realised that actually there is this strategy where we can supplement with a precursor in order to increase our energy levels, I found it really, really interesting. And I thought to give it a go myself and try it out and see the results. And then what shocked me was that the immediate effect of the supplement—so within a few days, you can already feel a difference in your energy levels and your focus. And this comes from the fact that sirtuins are responsible for so many molecular processes in the cell. And this is why you have this effect, including the mitochondrial biogenesis, which gives you basically increased ATP, consequently. Lisa: You get actually more mitochondria. So, like, if you got heart disease... Dr Elena: The production of more mitochondria, and then they produce more ATP as a result. And then you have this magic energy, yeah. This is why I thought to bring this product into the market. And the other reason was that there was not enough reliable suppliers on the market, which is crazy, because it's actually quite a popular supplement. It's been on the rise, the interest was rising for the past couple of years, but what we're seeing is there is a lot of white labelling companies that don't offer any certificates of analysis and so on. And also, you have even big companies not offering proper certificates of analysis, which was me like, it was… Yeah, I don't understand. You have a big company, and you have just the purity report from like, 18 months ago, and you don't have any other analysis, such as heavy metals, or pH or microorganisms. So, the consumer is actually not confident in buying from you. And I wanted to deliver the best quality for myself and my family. And then I said, ‘Wait a minute. This is not done, right’. And this is why I launched the company because I wanted a company that was completely transparent. And I even say it on the website, that if you're interested in finding out who our suppliers are, and so on, and have any questions about our supply chain, just feel free to reach out to me. And I would be happy to disclose all of those things. There are other companies that you can't find any registration number, or who the founder is, and so on. And it's quite confusing, really, because like you— you don't know who you deal with. Lisa: This is the same with the whole supplement industry. On the one hand, it's good that it's not regulated by the FDA, and whoever else, there are authorities around the world. Because like, then—they are turned into the pharmaceutical industry, which don't get me started. But on the other hand, there's not enough regulation around the quality control. And one of the things when I was searching for NMNs, searching the world for it, I had to go overseas and import it to friends in America and get it out of there. And this is why I like—was super excited to discover your work. And then, we've since now made it available down here. So, we're going to branch down here in New Zealand for New Zealand, Australia. And I wanted someone who I could trust, who has all the scientific knowledge behind it, there's all lab tests, etc. And that was really important for me for quality. Just on a side note. So I've been taking NMN now for—I think—so five, close to six months. I've had a massive weight loss and so as my mum. Why would that be? Like, I didn't take it for weight loss. I wasn't overweight, per se. But I had a couple of kilos that I was quite clear to get rid of. And what I've noticed—because I'm an athlete, that's my background—I haven't lost an ounce of muscle, which has been really awesome because most people are struggling to keep muscle mass, lose fat mass. My mum has lost 11 kilos. And she is of a genetic body type that really struggles with weight loss. She's conservation metabolism, from a genetic point of view, very, very hard for her to lose weight. So, I've never seen this in the history of her entire life, since I've been around. The weights just dropped off her. Is this some sort of upregulation in the metabolic pathways? Is it improving the insulin resistance? What's it doing there to cause such weight loss without muscle loss? Dr Elena: Well, in my study so far, there's definitely evidence that it does improve insulin sensitivity, and it also improves the lipid metabolism profile. So those two are very important. And unfortunately, we don't have those studies in humans yet. But more clinical studies are on the way, and hopefully we'll have very good results this year with the NMN besides the safety studies that we already have in humans. So in mice, what we're seeing is that there is basically a reverse of type two diabetes, which is really impressive. And if you want to correlate this data into humans somehow, I would say that, obviously, I'm not a medical doctor, and this is not a medical advice, but I would say that it does have to do something with the metabolism, and it basically improves the way your body metabolises everything. And... Lisa: Worth trying and there's no downside to NMN. There's no, it's a vitamin B derivative, well then you will say to me, ‘Well, can I just take B3 and be done’? and it's like, no, it doesn't work like that, which should be a lot cheaper. Dr Elena: That’s the other impressive thing about this compound is that it actually doesn't have, if any, side effects at all. So even in studies with mice, where the dosage that they use in mice is actually much higher than it is in the one that we usually have in humans. So, for instance, if someone would take 500 mg, or one gram of NMN per day in humans. And then in mice studies, they use something like 200 mg per kilogram of weight, which is much, much more, and it still doesn't have any side effects. Lisa: Does it mean that we need higher dosages? Like in the human, or has it only been tested to one gram and why has it not been tested higher, if that's the case? Dr Elena: No, I think that there are studies underway for this as well. So eventually, we will find what is the ideal dosage for humans. I think that from anecdotal evidence, people can already see results from 500 mg or one gram and so on. There are people that take more. So, some biohackers say that they take two grams or four grams, and is still very well tolerated. But yeah, so far, it does not produce any side effects in terms of… Lisa: Any downside. Dr Elena: Basically. And, for instance, for myself, my stomach is quite sensitive. So, when I'm on an empty stomach, I can't take vitamin C or caffeine and I get nauseous and so on. And this is not the case with an NMN. So, I can take it first. It is very well tolerated on an empty stomach, very mild. I really love it. There’s so many reasons to love it. Lisa: Yeah, yeah, yeah, I have my morning and night. So, I'm on a gram a day. And is there any reason not to take it at night? So I split the dose—reasoning, thinking, keeping the levels up? Dr Elena: I mean, I would probably take it all in the morning, I think. There's been a study out that it can affect the circadian rhythms as well. And interestingly, it actually affects NMN—sorry—NAD levels affects the circadian rhythm. But it's not the other way around. So, NAD actually dictates the circadian rhythm in the body. So, for this reason, I would suggest to take it in the morning because then your whole body synchronise, then you wake up and you tell to your body that look, it's the morning now, and we're going to have increased NAD level. Lisa: Increase. Ohh okay. So, okay, I got that wrong. I haven't noticed that I've had worse sleep or anything like that, or any rhythm has been out. But I would definitely swap to doing—my thinking process around that was keeping the tissue saturated over a 24-hour period, as opposed to all at once and then perhaps dropping, but I don't know. What is the half-life of it? Do you know? Is there any sort of evidence around that? Dr Elena: I actually, not sure. No, no. Lisa: There’s no evidence yet. And so yeah, there's a ton of studies still being done that are currently, like this year, like going to be coming out, which is going to be really exciting. So that we're going to get more evidence. I mean, there's this stuff that I've been reading around fertility in animal studies, and they're starting to do human studies, which I personally am very interested in, in reversing aging of the ovaries and even with... I mean, the mice study was incredible around fertility, where the mice were postmenopausal, they actually knocked off any existing eggs with chemotherapy. And then gave them NMN and the mice went on to have babies. And there was a whole study. Dr Elena: This is why I get so excited about NMN and this is why it's my first product because frankly speaking as a scientist, I've never seen results like that with a natural compound. Lisa: No? Dr Elena: Because there is a bunch of natural compounds out there, there is a bunch of other supplements. And what we're talking about spermidine the other day... Lisa: Yeah, yeah, it's interesting. Dr Elena: ...another autophagy activator. Quite an interesting supplement, yes. By the way, it's also an mTOR, independent autophagy activator, which is good. Lisa: Another very good reason to take that as well. And we were looking into that aren’t we, Elena about adding that? Dr Elena: Yeah, absolutely. We will look into this, but again, you don't see results, like the ones that you see with NMN in multiple studies from other compounds, it's really fascinating. Lisa: Wow, so yeah, so there are other products that are going to... And this is a super exciting thing, like were our grandparents or our parents even didn't get the chance, like, with aging was aging, and there was nothing that you really could do to influence how fast you aged. They weren't aware of it. And later on, it's become well, if you eat better and you exercise a little bit more and you stop smoking and, and stuff, you’ll age slower. But now we're taking exponential leaps in our knowledge. I mean, I fell into this realm when I was reading Dr David Sinclair's book, who is a very prominent scientist at Harvard Medical School, and made his book, Lifespan, which I totally recommend people reading. I was just like, ‘Oh my gosh, if I can stay healthy now’, because I'm 52, ‘if I can stay like, really, in top shape for another 10 years, by then we're going to have stuff that will help me live really long’. And that really excites me. And not just live long, but live healthier. Dr Elena: That’s the important part. The important part is not to just increase your age, it’s to increase your health span. So, the time that you're spending being healthy. And what you're referring to is actually called the aging escape velocity, where basically we’ll have more advanced research coming in every year of our lives. And this will eventually expand our lifespan, which is amazing. And I also think that if we preserve ourselves well, we might as well see this in our lifetimes, which will be amazing. Lisa: Absolutely. And I want another few decades, please. Listening to Dave Asprey, who by far, got... Dr Elena: I want another like, few hundreds. Lisa: Yeah, well, I mean, I know it sounds ridiculous right now. But if you listen to Dave Asprey saying conservatively, and Dr. David Sinclair, too, like, conservatively, we could live to 150, 180, and beyond. Then once they crack the code, and they're actually able to turn the cells back to which they are working on right now. And which they can actually go in the petri dish, from what I understand like with skin cells and make them immortal. And they can't do it in humans because it's too risky, they could turn you into a tumour and stuff. But with the Yamanaka factors that were discovered a decade or so ago, they're actually able to turn the clock back to the point of you being a 20-year-old again. And this is like, ‘Wow, this is pretty exciting. Being able to regrow nerves, spinal injuries, people who have gone blind from macular degeneration’ — all of these things are coming down the line. This is very, very exciting. Dr Elena: There are several advancements in this field. So, as I said, my PhD is also in stem cell biology. So, I was working with human embryonic stem cells in the lab, and what they can do on a dish is just mind blowing. Because what I was able to do was to take human embryonic stem cells, and then dictate their fate, basically, with different growth factors, and then differentiate them into neural precursors at first. And then to push them further in order to become terminally differentiated neurons. And like four weeks later, you basically have a human brain in a dish and it's a primary human cells. And it's an amazing, physiological irrelevant human platform as well to study disease. And this is what I was doing during my PhD. So, I’ve seen it with my own eyes. And every time I would do, I would go through this process, I would differentiate the human embryonic stem cells into neurons. It would be as exciting as the first time because of what it represents, because it does represent the progress that we've made so far. And I personally started human embryonic stem cells for the sake of drug discovery. So, I wasn't interested—my project was not focusing on different therapeutic applications. However, I know that there are many advancements in this field as well. So, we do have clinics in America, where you can have a total body rejuvenation, stem cells, and so on. And this technology is definitely advancing. And I've been actually thinking about the application of this for myself. So as you know, I recently had a dental injury. This is something to keep in mind for the future. So perhaps in the near future, I can just inject myself with a bit of a stem cells there... Lisa: And that’s already happening to a degree. I mean, I've got a doctor friend up north, who's doing stem cell replacement for joints, and so on, for degenerative joints. Because stem cells, basically, for people who don't understand why this is important. The stem cell is the original like cell, but before it decides, ‘Am I going to become a skin cell, or a neuron or a liver cell’, it differentiates. So, it's a pluripotent stem cell, it can become anything. And so, in the lab setting, you're going to be able to say, ‘Well I want your cell to become a liver cell’. Will we eventually be able to grow organs that can be used for transplantation? Is that sort of one of the end goals? Dr Elena: Absolutely. And it's already been done with some organs. So for instance, I've heard that there is a research group that basically 3D-printed a functional thyroid gland from stem cells. Lisa: Wow. 3D-printed. So, the printer gets these differentiated cells somehow, and then makes it into a functioning organ that they will eventually—they're going to be able to actually transplant this into people and save the whole organ donation, horrific troubles that we have currently. Dr Elena: Yeah, exactly and I think that we're not too far away from this from whole organs being recreated in the lab. We already are able to actually do a 3D culture in the lab and create the so called organoids. So for instance, from stem cells, you can do a brain organoid, where you have a liposphere and it basically consists of different kinds of cells that you see in the brain. So it would have neurons, it would have glial, it will have astrocytes, and then it would have this brain organoid and then you can study it. So, we're already getting there. We’re close, we’re much closer than we thought we were 20 years ago. And I think that we're not far away from having different kinds of organs being grown in the lab for transplants and so on. Lisa: Hopefully not our brains because it's the seed of who we are. Honestly reading Dr Sinclair's book, I was like, ‘Am I in a Star Trek movie or something’? because it is pretty, pretty amazing. But when you do this, you also ask that to understand the whole process and how the whole thing functions, and then you can actually really slow down neurodegeneration and optimise things. And so the NMN that we're talking about right now is the beginning of this really exciting road, which we're going to be staying abreast of. And hopefully adding to what we have available to the consumer right now for prices that are not moon money, that it's out of anybody's reach, but actually what you can do today so that you can preserve your health. So that in 10 years’ time, when the real crazy stuff starts coming on line, you'll be able to live longer and healthier lives. And that's the whole goal of it. So before we just wrap up, I just wanted to reiterate again, so how is autophagy—can you just put that—how is autophagy related to NAD and sirtuin genes? Can you just put that two pieces together again, just repeat that a little bit? Dr Elena: Sure. So basically, what happens is that you do need autophagy to recycle different damaged organelles in the cell when something goes wrong. So, and this is quite prominent in neurodegeneration because the reason we have—let's say, aggregate from proteins in neurons and dysfunctional mitochondria and so on is because neurons are terminally differentiated cells. This means that they don't divide anymore. So, they rely on autophagy in order to have their housekeeping function because they can't divide the junk away. Okay. So that's the reason why autophagy is important in terminally differentiated cells such as neurons. Lisa: So there's no hay flick limit for a neuron. There is just only one—when a neuron becomes a neuron, that's a neuron. Okay. Dr Elena: Yeah, yeah. And then that's it. And what happens with the activation of autophagy, one of the signals is—comes through sirtuin 1, which basically can activate the transcription factors that are related to autophagy activation, which is the TFEB transcription factor, EB and FOXO, which are basically influenced the activation of autophagy. And more specifically, the mitophagy as well. So, mitophagy is the arm of autophagy that is responsible for the mitochondrial clearance in the cell. Lisa: Yep, so mitochondria, just for people, are the powerhouses of the cell. This is where a lot of—so all of the energy is produced, if you like. And so, this is why mitophagy, as opposed to autophagy, so mitophagy is doing the same process, but within the mitochondria to keep your mitochondria healthy. And if your mitochondria are not healthy, and they're dying, and you're not having enough mitochondria in your cells, then you are going to be sick. And that could be heart disease, it could be neurodegeneration, that could be anything. So, keeping your mitochondria healthy is the basis of all bloody disease, blatantly. Dr Elena: Yeah, exactly. So then, if you have impaired autophagy in the cell, and then you also have some sort of DNA damage going on, such as the one from reactive oxygen species, for example. And then what you have is the activation of the PARP enzymes. And PARP enzymes heavily rely on NAD levels in the cell in order to function. And NAD is also a substrate for the sirtuin genes that are responsible for also regulating a bunch of very healthy, a bunch of processes in the healthy cell. And for this reason, if you do have increased activation of PARPS, you will eventually get this NAD drain out of the cell. And this will not be enough in order for the sirtuins to function properly. And this will also deplete your autophagy. So, both NAD levels and autophagy are important to the cell. And fortunately for us, we can actually replenish the levels of NAD by supplementing with an ad precursor such as an NMN. Lisa: Okay, and so NMN has been proven to be by most of our bio available, because there's also like nicotinamide riboside which is used in a number of supplement companies that I know have nicotinamide riboside, but not many, there are some now, but have nicotinamide mononucleotide. Nicotinamide riboside is also a great molecule, but it's two steps away from becoming NAD. As long as it’s available. Dr Elena: Yeah, so nicotinamide riboside needs to be phosphorylated and fast converted to nicotinamide mononucleotide first. And then this will enter the cell and then this will increase the levels of NAD in the cell. And for this reason—so first, this area of research was focusing on the NR molecule, the nicotinamide riboside. But then when they started studying NMN, they actually saw that there is increased bioavailability and there is increased levels of energy that come after supplementation with NMN. Lisa: Can you take—because NAD is a molecule, you cannot just take it as a capsule, and then it's all good to go. Can you take it as an infusion because I have heard of NAD infusions. I mean, it’s not available here. Dr Elena: Well, and I'm curious myself about this, and I haven't done it, I haven't tested it. And from what I've seen—so the concentration of NAD in those intravenous injections is quite low. And I think that the same way that we have many opportunistic companies in the supplement field, we also have many opportunistic clinics that offer this kind of treatments. So, again, this is not something that I have studied in depth, and I actually don't know how much will it help. But yeah, I mean, this is another way to boost NAD, I guess, and you can try it out. But with oral administration of NMN, we do have evidence that it can boost the levels of NAD in the tissue and in liver tissue and muscle tissue, and so on. And also, it's much easier to do and it's obviously much cheaper because those injections cost a lot. Lisa: Yes, yeah. Just one last question in relation to antioxidants, because I mean 10 years ago or so we used to think our reactive oxygen species ,oxidative stress happens through the electron transport chain. When we're metabolising, and so on, we get all these oxidative stresses and free radicals running around. And if we take antioxidants, we're going to be counterbalancing that. Does supplementing with antioxidants, like vitamin D, like glutathione, like vitamin C, and so on, alpha lipoic acid, is that going to contribute, too, to the slowing of aging, because it's going to down regulate the PARP enzymes? Dr Elena: People were very optimistic about antioxidants, something like 20 years ago. And everyone was talking about it and so on. But actually, the big studies that have been done, have shown that by taking antioxidants, you actually do not suppress aging. And there are some biomarkers that might have changed in those studies. But most of the biomarkers that they measure stay the same. Basically, saying that antioxidant is not the... Lisa: Not the holy grail. Dr Elena: ...that everyone was thinking about. Lisa: Was hoping, yeah. Not to say that antioxidants don't have their place because they definitely do. Especially if you have a lot of oxidative stress, and you need to, like with vitamin C, if you're infected, or—I've done a whole series on vitamin C. But then it's not the holy grail for stopping the aging process, but it probably does help with not having so much PARP activation. I don't know, as a non-scientific brain, I'm just connecting dots. Okay, so I think it's probably we've— so from a lifestyle intervention, apart from taking NMN and resveratrol, and oleic acid or olive oil, intermittent fasting, is there anything else that we can add to our anti-aging regime on a lifestyle intervention side? Dr Elena: Intermittent fasting, and then avoid exposure to sunlight, as we said. And sirtuin genes are being activated from any kind of stress. And what we can do is we can also induce some sort of an artificial stress, which could be done, let's say with cryotherapy. This is what cryotherapy does. When you're exposed to cold, you also have this stress signal that activates sirtuins, or the other way around, so you can try out a sauna. And this will also have the same effect. So, I think this is also something to keep in mind. Lisa: Breathing, breathing. So, sort of tumour breathing, or, like what one half does all of that sort of stuff. So, there’s hormetic stressors, there’s exercise obviously, that cause a cascade of changes and make you stronger. And yeah, it's sort of a balancing act. You don't want to be doing exercise for Africa or really freezing yourself to death, but you just want to have a little stress to cause a change in the body. So these hormetic stressors can be very, very helpful. Okay, well, I think we've covered a very, very, very complex topic and I hope we didn't lose everybody on the way. But at the end of the day, take NMN, take resveratrol, take olive oil, do your exercise, get in the sauna, if you have a chance to do cold therapy, do that as well. Get your exercise, get your antioxidants in there as well, to a certain degree and you're going to be able to live long enough but until other things come online, and you'll be able to improve everything. Dr Elena: Sounds good. Lisa: Brilliant. So Dr. Elena, thank you very much. Dr. Elena has been on the show, NMN Bio. So we have nmnbio.co.uk in UK and in Europe, and nmnbio.nz if you're down at this end of the world. We'd love to help you over the air. If you've got any other questions, please reach out to us. And thanks very much for being here today. It's been really exciting. Dr Elena: Thank you, Lisa, thank you so much for having me. That's it this week for Pushing the Limits. Be sure to
Διάλογος: -Καλημέρα σας, όλα καλά με το δωμάτιο; -Ναι, μια χαρά. Είναι πολύ όμορφο και καθαρό. -Χαίρομαι πολύ. Tο νησί μας; Σας αρέσει; -Με μια πρώτη ματιά, είναι πανέμορφο. Και οι παραλίες είναι εξαιρετικές. Περνάμε όλη τη μέρα εκεί. Εμείς είμαστε από τα Γιάννενα. Γι' αυτό, δεν πηγαίνουμε συχνά στη θάλασσα. -Καταλαβαίνω. Επίσης, στο λιμάνι, υπάρχουν και μικρά καράβια που κάνουν τον γύρο του νησιού σε μια μέρα. Και άλλα που κάνουν κρουαζιέρα και σας πηγαίνουν στα νησιά που είναι δίπλα. -Πολύ ωραία. Θα κάνουμε μάλλον την Πέμπτη. Πώς είναι η ζωή στο νησί; -Το καλοκαίρι, το νησί είναι πολύ ζωντανό : έχουμε κόσμο από όλα τα μέρη της γης. Τον χειμώνα η ζωή είναι πολύ πιο ήσυχη. -Αλλάζει η ζωή σας από τη μια εποχή στην άλλη. -Ακριβώς. -Μπορούμε να πάρουμε το πρωινό στην πισίνα; -Φυσικά. Καλή σας όρεξη. -Ευχαριστούμε. Καλή σας μέρα. Translation: -Good morning, is everything ok with the room? -Yes, everything is fine. It is very beautiful and clean. -Happy to hear that. Our island? Do you like it? -At first glance, it's beautiful. And the beaches are great. We spend all day there. We are from Ioannina. That's why we do not go to sea often. -I understand. Also, in the port, there are small boats that make the tour of the island in one day. And others that cruise and take you to the nearby islands. -Very nice. We will probably do it on Thursday. How is life on the island? -In summer, the island is very lively: we have people from all over the world. In winter life is much quieter. -Your life changes from one season to the other. -Exactly. -Can we have breakfast by the pool? -Of course. Bon appetit. -Thanks. Have a nice day. --- Send in a voice message: https://anchor.fm/learning-greek-a-modern-o/message
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Afterfeast of the Meeting of our Lord in the Temple ........................................................................................... 17 Holy, Righteous Simeon the God-Receiver ........................................................................................................... 17 Prophet Azariah ...................................................................................................................................................... 20 Martyrs Papias, Diodorus and Claudianus, at Perge in Pamphylia ................................................................... 21 Saint Sabbas of Ioannina ........................................................................................................................................ 21 Martyr Adrian at Caesarea, Cappadocia .............................................................................................................. 22 Martyr Eubulus at Caesarea, Cappadocia ............................................................................................................ 22 Martyr Blaise of Caesarea, in Cappadocia ........................................................................................................... 22 Saint Simeon, Bishop of Polotsk and Tver ............................................................................................................ 23 Saint Jacob, Archbishop of Serbia ......................................................................................................................... 23 --- Send in a voice message: https://anchor.fm/an-orthodox/message
Philipp Deutscher has been based in Greece since 2019, as Managing Director of the German software company Teamviewer's new R&D facility in the city of Ioannina. Teamviewer, valued at 5.3 Billion Euros, is known for its remote working and Desktop Sharing solutions- which have seen marked growth during the pandemic and the ‘work from home' era. Philipp talks about the decision to invest in Ioannina, the challenges and opportunities he sees in Foreign Direct Investment, and his first impressions of working in Greece. Ο Philipp Deutscher ζει και εργάζεται στην Ελλάδα για την Γερμανική εταιρεία λογισμικού Teamviewer από το 2019, ως συντονιστής του νέου κέντρου R&D της εταιρείας στα Ιωάννινα. Η πιο γνωστή υπηρεσία της Teamviewer, με αποτίμηση τα 5.3 δισεκατομμύρια ευρώ, είναι το λογισμικό απομακρυσμένου ελέγχου υπολογιστών (remote working) και κοινής χρήσης επιφάνειας εργασίας (remote desktop sharing). Το λογισμικό αυτό γνώρισε τεράστια ανάπτυξη την περίοδο της πανδημίας και της εξ αποστάσεως εργασίας. Ο Philipp μιλάει για την επένδυση στα Ιωάννινα, τις προκλήσεις και τις ευκαιρίες που βλέπει στις Άμεσες Ξένες Επενδύσεις (FDI) και για τις πρώτες εντυπώσεις του από την Ελλάδα. Η συνέντευξη έγινε στα αγγλικά.
Νέα απώλεια βαθμών υπέστη ο Άρης, που συν τοις άλλοις προσφέρει στον Ολυμπιακό αυξημένο προβάδισμα στην κορυφή.
Ioannina ass d'Haaptstad vun der griichescher Regioun Epirus, am Nordweste vum Land. D'Stad war iwwer Joerhonnerten en Zentrum fir jiddesch Kultur. Ënner der däitscher Occupatioun goufen allerdéngs déi meeschte Membere vun dëser Communautéit ëmbruecht. Haut ass déi jiddesch Glawensgemeinschaft Ioannina esou kleng, datt se bal keng Masse méi feiere kann. D'Judde vun Ioannina hu wëlles, e Musée opzebauen, fir d'Erënnerung un dat jiddescht Liewen zu Ioannina laangfristeg ze erhalen. Aus Griichenland den ARD-Korrespondent Thomas Bormann.
Autor: Bormann, Thomas Sendung: Tag für Tag Hören bis: 19.01.2038 04:14
1 an... 1 an que j'ai créé mon Podcast et aujourd'hui j'aimerais te partager ces quelques mots rien que pour toi. Merci. Rejoins moi : Instagram : www.instagram.com/volllange/?hl=fr YouTube : www.youtube.com/channel/UCuYcMbAF…iew_as=subscriber Télécharger ton EBOOK GRATUIT spécial lâcher prise : volllangeandlife.wixsite.com/bloglife/e…ok-gratuit Pour télécharger les notes du Podcast : volllangeandlife.wixsite.com/bloglife/podcasts Pour aller voir mon Blog : volllangeandlife.wixsite.com/bloglife Si tu souhaites t'abonner à ma Newsletter pour avoir davantage de conseils sur le développement personnel et la reconstruction : volllangeandlife.wixsite.com/bloglife/newsletters N'hésites pas à rejoindre le mouvement que j'ai créé sur Instagram en utilisant le #volllangelife. Publies et Partages à volonté ! Musique par Nordgroove: icons8.com/music/author/nordgroove de Fugue: /music "Ioannina in timelapse" by Drone Photography. Creative Commons Attribution License. View the original here: https://www.youtube.com/watch?v=a9XkE...
This episode is dedicated to the trade of a culinary ingredient that involves multiple orchid species. Salep is derived from the tubers of many terrestrial orchids and no one really understands how modern demand for this ingredient is affecting their populations in the wild. Joining us to talk about this are PhD candidate Martha Charitonidou and Dr. John Halley from the University of Ioannina in Greece. Their lab is uncovering vital insights into how the growing demand from affluent countries for naturally sourced products like salep can begin to crumble centuries of traditional harvesting practices. This is an important episode for anyone interested in conservation and culture. This podcast was produced in part by Bryce, Brittany, Helen, Amanda, Mikey, Rhiannon, Michelle, Kate, German, Joerg, Alejandra, Cathy, Jordan, Judy, Steve, Kae, Carole, Mr. Keith Santner, Dana, Chloe, Aaron, Sara, Kenned, Vaibhav, Kendall, Christina, Brett, Jocelyn, Kathleen, Ethan, Kaylee, Runaway Goldfish, Ryan, Donica, Chris, Shamora, Alana, Laura, Alice, Sarah, Rachel, Joanna, Griff, Philip, Paul, Matthew, Clark, Bobby, Kate, Steven, Brittney, McMansion Hell, Joey, Catherine, Brandon, Hall, Vegreville Creek and Wetlands Fund, Kevin, Oliver, John, Johansson, Christina, Jared, Hannah, Katy Pye, Brandon, Gwen, Carly, Stephen, Botanical Tours, Moonwort Studios, Liba, Mohsin Kazmi Takes Pictures, doeg, Clifton, Stephanie, Benjamin, Eli, Rachael, Plant By Design, Philip, Brent, Ron, Tim, Homestead Brooklyn, Brodie, Kevin, Sophia, Mark, Rens, Bendix, Irene, Holly, Caitlin, Manuel, Jennifer, Sara, and Margie.
Bucharest Sketches is the fifth in the series of field recordings albums by Toni Dimitrov dedicated to a city. After the field recordings from Athens (released on Green Field Recordings), Milan and Ioannina (released on Auriculab), and Belgrade (released on Silber Records), this time the sketches are recorded in Bucharest during the stay in Romania for a field recording residency in the Danube Delta, Sonic Future Residencies, in the summer of 2019. You can hear the Bucharest streets, parks, the noise from the rain, fountains, interweaving subtly, blurring the line between field recording and sound art. Articolul Bucharest Sketches apare prima dată în SEMI SILENT.
A Grécia, oficialmente República Helênica é um país europeu localizado na parte meridional dos balcãs e confina a norte com a Ex-República Yugoslava da Macedônia (FYROM), com a Bulgária, e com a Albânia, a leste com a Turquia, quer em fronteira terrestre, quer com fronteira marítima no mar Egeu, a sul com o mar Mediterrâneo e a oeste com o mar Jônico, pelo qual tem ligação com a Itália. Localizada na junção da Europa, Ásia e África, a Grécia é o berço de nascimento da democracia, da filosofia ocidental, dos Jogos Olímpicos, da literatura ocidental e da historiografia, bem como da ciência política, e dos mais importantes princípios matemáticos, e também o berço de nascimento do teatro ocidental, incluindo os gêneros do drama, tragédia e o da comédia. É membro da União Europeia desde 1981, membro da União Econômica e Monetária da União Europeia desde 2001, OTAN desde 1952, OCDE desde 1961, UEO desde 1995, membro fundador da Organização de Cooperação Econômica do Mar Negro e membro da AEE desde 2005. Atenas é a capital; outras importantes cidades do país são Thessalonica, Pátras, Iráclio, Larissa, Volos, Ioannina, Cavala e Rhodes. Neste 25 de Março, a Grécia completa 190 anos da libertação otomana. PROGRAMA VIDA INTELIGENTE com Eustáquio Patounas Quinta-Feira, 8 às 9 da noite, AO VIVO TV Floripa Canal 4 da NET www.vidainteligente.blogspot.com www.vidainteligente.tv.br
Encore de grosses découvertes cette semaine, dans ce balado de deux heures consacré au rock: Valence, Richelieu, HMLTD, Those Pretty Wrongs, Husband, Retrospecter, Michaëlle Richer, Hurt Valley, Du Blonde, Necking, Murmure et autre Weatherday. Et les animateurs Stéphane Deslauriers et Philippe Beauchemin se posent de grandes questions existentielles du genre : est-ce possible de prononcer "Ioannina" (comme dans le nom du groupe Villagers of Ioannina City) sans bafouer ? Et, surtout, qui est le batteur en tournée de Fernand Gignac ? Du gros plaisir encore dans ce balado où le rock vole très haut. Bonne écoute.
The SNF DIALOGUES series of monthly events took its first trip outside Athens. A great number of friends of the event, which was open free and open to all, accompanied the SNF Dialogues in its first “escape” outside Athens, and traveled to Syros, the birthplace of Markos Vamvakaris. The visit to Syros took place in accordance with the event's theme, which was dedicated to the history of rebetiko. The event, which was hosted at the premises of the unique Syros Textile Factory, featured Dimitris Mistakidis, musician and teacher at the School of Arts in the Department of Traditional Music at the University of Ioannina, Giorgos Kokkonis, Assistant Professor in the Department of Music Studies at the University of Ioannina, and Karolos and Tanya Veanus Tsakirian, luthiers. The speakers shared their rich knowledge of the roots and influence of Rebetiko on the world music scene, its sociological value, its relatively recent destigmatization, and the cultural trends that have transported it across the globe. The event featured a presentation of the work of the tireless Rebetiko researcher , Panagiotis Kounadis. Mr. Kounadis has recently been developing, with the support of the SNF, a Virtual Museum dedicated to rebetiko. The project is implemented with scientific support from the University of the Aegean, which participates through its Department of Product & Systems Design Engineering, based in Syros. The Kounadis Archive is one of the best-organized archives, primarily featuring the urban folk music of 1900-1960. Established in 2007, it contains one of the richest collections of rebetiko music recordings and manuscripts, illustrating the uptick in creative musical composing during that era in Greece and abroad.
Our guest today is Dr. John Ioannidis, a Stanford professor who has been described by “BMJ” as “the scourge of sloppy science.” Atlantic magazine has gone so far as to refer to him as one of the world’s most influential scientists. John is renowned for his 2005 paper, “Why Most Published Research Findings Are False,” which has been viewed more than 2.5 million times and is the most citied article in the history of the journal PLoS Medicine. He has authored nearly a thousand academic papers and has served on the editorial board of 30 top-tier journals. At Stanford, John is a professor of medicine, of health research and policy, and of biomedical data science in the school of medicine as well as a professor of statistics in the school of humanities and sciences. He is the co-director of the university’s Meta-Research Innovation Center and the former director of the Stanford Prevention Research Center. In today’s wide-ranging interview, John talks about: [00:07:43] What led him to begin questioning the reliability of medical research during his residency at Harvard. [00:12:03] His 2005 paper, “Why Most Published Research Findings Are False.” [00:26:27] How a major issue facing science is a lack of replication. [00:30:51] Which studies are worse, nutritional studies or drug studies. [00:38:25] If it’s possible to remove sampling biases like the healthy user bias. [00:46:50] The need for scientists to disclose their personal dietary biases as well as their personal diets when publishing research findings. [00:52:40] His recent paper, “Evidence Based Medicine Has Been Hijacked,” which argues that vested interests have transformed clinical medicine into something that resembles finance-based medicine. [00:55:36] The impact that funding pressure is having on the veracity of research being done today. [01:08:42] The need for future research to be designed by scientists without vested interests. [01:14:58] The ways John would fix the system if he had magic wand. [01:18:42] And as a bonus, John reads an excerpt from his latest book. Show notes: [00:02:37] Dawn begins the interview asking John about being born in New York but raised in Athens. [00:03:54] John talks about how his parents were physicians and researchers and how they instilled in him a love for mathematics at an early age. [00:05:26] Dawn asks John about winning the Greek Mathematical Society’s national award when he was 19 years old. [00:06:23] John talks about his decision to go to medical school and to attend Harvard. [00:07:43] Ken mentions that John began questioning the reliability of medical school during his residency at Harvard, and asks John to talk about his interest in an “evidence-based medicine” movement that was gathering momentum at the time. [00:08:47] Dawn asks John about his work with the late Tom Chalmers, who played a major role in the development of randomized controlled trials. [00:09:58] John talks about returning to Greece to take a position at the University of Ioannina. [00:12:03] John talks about his 2005 paper “Why Most Published Research Findings Are False,” which became the single most-cited and downloaded paper in the history of the journal PLoS Medicine. [00:15:32] Dawn mentions that when the paper came out, it was theoretical model. She asks John to talk about how now there are a number of studies pointing out problems with preclinical research on drug targets. [00:17:34] Dawn asks John about his decision to leave the University of Ioannina to take a position at Stanford University. [00:21:02] Dawn asks John for his thoughts on ways to improve the peer-review process. [00:24:09] John talks about how he and his colleagues have found that most medical information that doctors rely on is flawed. [00:26:27] Dawn points out that a major issue facing science is a lack of replication. She talks about how funding for repeat studies is hard to come by and that ma...
The Creative Process · Seasons 1 2 3 · Arts, Culture & Society
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
The Creative Process · Seasons 1 2 3 · Arts, Culture & Society
Dr. George Maginis is the Academic Director of the Benaki Museum in Athens Greece. He holds a PhD in archaology and history of art. He has taught Byzantine, Islamic, and Chinese Art History at the University of London for SOAS and the Courtauld Institute of Art (University of London), the Victoria & Albert Museum, the British Museum. He has excavated in Greece, Cyprus, France and Egypt, and has worked for the Hellenic Children's Museum and the Archaeological Museum of Ioannina. He has also acted as museum development consultant in the United Kingdom.· www.benaki.org · benaki.academia.edu/GeorgeManginis · www.creativeprocess.info
Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Today's feature paper is going to cause us to rethink the way we prognosticate patients with pulmonary arterial hypertension following their initial management. Think you know the hemodynamic variables? Well, stay tuned for this discussion coming right up after these summaries: Our first original paper this week shows for the first time the predictive value of coronary artery calcification progression for coronary and cardiovascular events in a population base study. Authors Dr. Erbel and Lehmann from University Hospital Essen in Germany and their colleagues evaluated several progression algorithms between CTs performed at baseline and after a mean of five years for the risk prediction of coronary and cardiovascular events in a population base cohort of more than 3,200 participants initially free from cardiovascular disease. The authors found that coronary artery calcification progression added some predictive value to the baseline CT and risk assessment, and even when the five-year risk factors were taken into account. However, the progression yielded no additional benefit when the five-year coronary artery calcification results were taken into account instead of the baseline coronary artery calcification results. Double zero coronary artery calcification scans in a five-year interval meant an excellent prognosis, which was better than the prognosis for incident coronary artery calcification after five years. Thus, the authors concluded that sophisticated coronary artery calcification progression algorithms may be unnecessary and clinicians can instead rely on the most recent risk and coronary artery calcification assessment. The next paper demonstrates for the first time cell-specific effects of Smad3 signaling in the infarcted myocardium. Now, in the infarcted heart, Smad3 signaling is known to be activated in both cardiomyocytes and the interstitial cells. In the current paper, co-first authors, Doctors Kong and Shinde, corresponding author Dr. Frangogiannis from Albert Einstein College of Medicine in New York, and their colleagues hypothesized that cell-specific actions of Smad3 may regulate, repair, and remodeling in the infarcted myocardium. In order to dissect the cell-specific Smad3 actions in myocardial infarction, these authors generated mice with Smad3 loss specifically in activated fibroblasts or in cardiomyocytes. They found that fibroblast-specific Smad3 activation played a critical role in repair following myocardial infarction by restraining fibroblast proliferation and contributing to scar organization by stimulating integrin synthesis. On the other hand, cardiomyocyte-specific Smad3 signaling did not affect acute ischemic injury, but triggered nitrosative stress and induced matrix metalloproteinase expression in the remodeling myocardium, thereby promoting cardiomyocyte death and contributing to systolic dysfunction. In summary therefore, these authors demonstrated the cellular specificity of Smad3-dependent actions that stimulate distinct cellular responses in fibroblasts versus cardiomyocytes in the healing myocardial infarction. The implications are that nonspecific therapeutic targeting of Smad3 signaling in pathologic conditions may interfere with both detrimental and beneficial actions. On the other hand, design of interventions with specific cellular targets may be needed for the development of safe and effective therapies. Good news from the next paper! Genetically predetermined high blood pressure and its complications may be offset by healthy lifestyle. Well, at least, to some extent. First author, Dr. Pazoki, co-corresponding authors Dr. Elliott from Imperial College London and Dr. Tzoulaki from University of Ioannina in Greece aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse blood pressure genetic profile as well as its effects on cardiovascular disease risk. To do this, they constructed a genetic risk score for high blood pressure using 314 published blood pressure loci in more than 277,000 individuals without previous cardiovascular disease from the UK Biobank study. They scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. They examined the association between tertiles of genetic risk and tertiles of lifestyle score with blood pressure levels and incident cardiovascular disease. They found that adherence to a healthy lifestyle was associated with lower blood pressure regardless of the underlying blood pressure genetic risk. Furthermore, adherence to a healthy lifestyle was also associated with lower risk of myocardial infarction, stroke, and the composite cardiovascular disease at all levels of underlying blood pressure genetic risk. Healthy compared to unhealthy lifestyle showed a 30%, 31%, and 33% lower risk of cardiovascular disease respectively among participants at low, middle, and high genetic risk groups. Thus, these results strongly support population-wide efforts to lower blood pressure and subsequent cardiovascular disease risk through lifestyle modification. The final paper is an aggregate report from two large randomized trials, which demonstrate for the first time that more potent antiplatelet therapy further lowers venous thromboembolism risk relative to aspirin alone. First author Dr. Cavallari, corresponding author Dr. Bonaca, and colleagues from the TIMI Study Group in the Brigham and Women's Hospital ascertained and characterized symptomatic venous thromboembolism events in more than 47,600 patients randomized in the TRA 2°P-TIMI 50 and PEGASUS-TIMI 54 trials. They evaluated risk of symptomatic venous thromboembolism over time, independent risk factors for venous thromboembolism, and the efficacy of more intensive antiplatelet strategies at reducing venous thromboembolism risk. They found that the rate of venous thromboembolism in patients with atherosclerosis was 0.3% per year while on treatment with at least one antiplatelet agent. This risk increased independently with the number of symptomatic vascular territories. Furthermore, more intensive antiplatelet therapy with Vorapaxar and Ticagrelor in this case reduced the risk of venous thromboembolism. These data suggested a relationship between atherosclerosis burden and venous thromboembolism risk. The data also support the inclusion of venous thromboembolism as a prospective endpoint in long-term secondary prevention trials evaluating the risks versus benefits of antiplatelet therapies in patients with atherosclerosis. Well, that wraps it up for our summaries. Now for our feature discussion. For our feature discussion today, we are talking about pulmonary arterial hypertension. We've learned so much from registries about prognostication of pulmonary arterial hypertension at the time of diagnosis. But these registries have only provided limited insight into the impact of therapies on long-term outcomes and how we're supposed to use variables after initiation of therapy to determine prognosis. Well, that gap is being filled by today's paper in circulation. I'm so pleased to have the first and corresponding author with us, Dr. Jason Weatherald from University of Calgary, as well as Dr. Kelly Chin, associate editor from UT Southwestern, to discuss this very important paper. Jason, congratulations on this paper. Could you tell us a bit more about what you did and why you did it, and what's exciting about what you found? Dr. Jason Weatherald: This is a study that started during my research fellowship last year when I was spending time in Paris with the group of Professor Olivier Sitbon and Marc Humbert. We started this study based on some other recent papers showing the importance of pulmonary arterial compliance, and some smaller studies that emphasized the importance of hemodynamic variables after treatment initiation and the prognostic importance of that. We wanted to look at the relative importance of pulmonary arterial compliance as well as the stroke volume in the cardiac index in newly diagnosed patients. We looked at a 10-year cohort from the French registry of patients who had right heart catheterizations at baseline and then after treatment initiation. We looked at prognostic variables, both at baseline and at the first follow-up after initial treatment. The interesting result is that we found that actually pulmonary arterial compliance is not the most important prognostic variable, but it seemed that the stroke volume index, which was calculated from the cardiac index and the heart rate, was the most significant independent predictor of long-term survival from the hemodynamic perspective. Dr. Carolyn Lam: Kelly, could you help point out why this is so important in clinical practice? You see a lot of these patients. In what way did this paper make you think differently about them? Dr. Kelly Chin: I think there's a couple different areas that really struck me. The first one was, as you mentioned in the introduction, the importance of post treatment values versus baseline values. This is not to say that the baseline values aren't important because it does still associate with survival and it's very important when choosing therapy, but as PAH therapies have become more effective, we would hope to see that the baseline severity matters less and that, indeed, seems to be what we're seeing here. That also reinforces the importance of serial reassessment to see how your patient is doing and make further decisions for therapy. The second key finding, I think, is what Jason was just talking about with which hemodynamic measures do we really want to be keeping a close eye on? Here's where, in the stepwise analysis, they found that the right atrial pressure and then, the surprising one, the stroke volume index were the key measures that were associated. Interestingly, cardiac index fell out of that model. That isn't to say that cardiac index wasn't associated with outcome. It was a predictor in the univariate analysis. But I think when you step back and you think about the comparison between those two, if you have a patient who's maintaining their cardiac index only by becoming tachycardic, they're probably not doing nearly as well as a patient who has a normal heart rate and a normal stroke volume index. I think this really struck me as something, "Hey, when I'm in the cath lab, I probably need to be thinking about this and reporting it out, so everybody's seeing it right there on the report", which is not something we've been doing. Dr. Carolyn Lam: Thanks Kelly. That makes so much sense. What I really appreciated about the paper as well is that they gave us practical thresholds through their receiver operating characteristic analyses. Just for everyone to know, the threshold value for stroke volume index was 38 mils per minute per meter square, right? And the right atrial pressure threshold was 9 mils of mercury. These are sort of very important, 38 and 9, and practical to keep in mind. Really appreciate that Jason. The other thing that struck me is these are just very much saying that right ventricular function is important. Is it not, Jason? Dr. Jason Weatherald: Yeah, I agree. I think that's one of the interesting insights from the study is that we focused mostly on the cardiac index, but it can be misleading in certain patients like Kelly said who perhaps do respond to therapy by increasing the cardiac index but predominantly through increased heart rate. That can be somewhat misleading if you don't really step back and look at it. What I found interesting, too, is that when we looked at subgroups of patients who, in the clinic, you generally think are low risk patients who had good six-minute walk distance, very few symptoms NYHA functional class I or II, and had a cardiac index above the current recommended target of 2.5, that there was almost a third of patients with a low stroke volume index in that category and that seemed to be the majority of patients who died over long-term follow-up within five years. I think that's really telling about the importance of right ventricular function and just looking at the cardiac index itself can perhaps mislead you if you don't take all of those other factors into consideration. Dr. Carolyn Lam: Yeah, that's just such a great point and important. That even those classified that we would not have picked up as high risk are the usual measures that we look at. If you look at stroke volume index, they still distinguish those who do better than those who do worse. This is something that was also highlighted, I think, in the accompanying editorial, Kelly, that you invited by Lewis Rubin from New York. Kelly, what do you think are the real take home messages from this? Dr. Kelly Chin: I think he does make a big point that the functional status of the right ventricle is a primary goal of therapy, and that we should definitely be paying attention to it and that there's more than one way to do this. There's the hemodynamic measurements, there's also exercise capacity and functional class, which really do associate with how well the right heart is functioning, both at rest and exercise. I think he also comes back to the serial measurements and the importance of reassessment. Dr. Carolyn Lam: Yeah, as you had also so elegantly summarized earlier. But, a quick question to both of you. What do we do now about other measures of right heart function? I mean, magnetic resonance imaging seems to be used increasingly for this. Where does this fall in? And what does this say about the routine clinical parameters that we usually look at, like six-minute walk? Jason? Dr. Jason Weatherald: I have a couple points on that. Number one, I fully agree and our results are really in keeping with the previous smaller studies looking at cardiac magnetic resonance and showing the importance of the stroke volume on imaging. From personal experience, although MR is wonderful, there's a good population of patients who don't really tolerate MR, especially for serial measurements, and there's other contraindications, so I think hemodynamics will continue to fill an important role and are still useful in the patient where you can't figure out exactly what's going on and why they're getting worse. At this point, I think it's complementary and certainly I think there's some centers in many countries that don't have cardiac MR widely accessible, especially for serial follow-ups, so I think they're really complementary and that our results support imaging studies. I would say the next thing about the study is that, in the multi variable models that exercise distance, the six-minute walk distance and functional capacity remained independent predictors, so I think, it just highlights the importance and the robustness of these measures, even though NYHA functional class is subjective, it remains a very powerful predictor at baseline and during follow-up. To me, it speaks to the importance of looking at multiple parameters and coming to a multidimensional assessment of risk and PAH and not focusing on one particular variable for making decisions in the clinic. Dr. Kelly Chin: I definitely agree with the multidimensional look at a patient function and heart and catheterization. What I was going to say was I also liked, Jason, the use of "complementary" when talking about catheterization and MRI. I see MRI filling a similar niche to echo for many patients. I think if you get an echo and it looks great, heart size is good, heart function is good, I don't see a whole lot of reason to add an MRI, too. We're always routinely doing catheterizations, at least early post treatment, to reassess. But I do see a role for MRI in some of our patients who are doing not well at all, but we're not quite sure if they're doing poorly enough that it's time for transplant, and I'm trying to decide if the RV is growing or not. It's clearly big, but is it getting bigger each six months that we're looking at it? Sometimes MRI just seems to provide so much more precision than we can get with echo and certainly you're not getting any of those types of measures off of your catheterization. Dr. Carolyn Lam: Maybe one last question Jason. It's so interesting. What is the future? What are the gaps that you're looking to fill at the moment? Dr. Jason Weatherald: Ideally, I think it would be a noninvasive way to look at the right ventricle that is cheap, reproducible, and gives us the same confidence that invasive hemodynamics do. Although I find echo is indispensable and MRI is very useful, I think at the end of the day, we all go back to the right heart catheterization and we need to find something that can replace that, but give us the same confidence in what we think we're measuring and that it reflects treatment changes and clinical worsening. Dr. Carolyn Lam: And Kelly, what do you think should be next steps? Dr. Kelly Chin: I have to say I really liked this study. I thought it moves us forward in assessment of prognosis for this population of patients in a really big way. It was large and included a large number of measures that were done very carefully. You always want to see replication. But, what I'd also like to see is the other forms of pulmonary arterial hypertension. You know this focused mainly on the idiopathic PAH patients, so what happens in connective tissue disease, and also what happens late after treatment, because I think we sometimes see a little bit of a different phenotype in patients that we've treated for many years and sometimes hemodynamics have improved, but in different ways than what we see early on with initial therapies. Dr. Carolyn Lam: You've been listening to Circulation on the Run. Tune in again next week.
Podcasts from A Diet of Brussels, talking about the issues around the UK's forthcoming referendum on membership of the EU. Website: www.adietofbrussels.com
The greek poet ILIAS FOUKIS , was born on 20 August 1969 in Ioannina in Epirus in northwestern Greece. Began to write poetry since 1988 when he was student in the Lyceum. Published volume of poetry THE TESTAMENT OF A LESSER GOD , which has been translated into ten languages ??including English, French, Italian, Spanish, Portuguese, etc.. Has won literary awards - OSCAR DE DOS OURO VENCEDORES, Brazil 2012 - MASSIMO D'AZEGLIO, Italy, 2012, 2013 - CIT ?T? A DEL GALATEO, Italy in 2013. His poem titled YOUNG GREEK SOLITARY was included in Poetry Anthology - U.S. Library of Congress. Works and lives in Athens.
Bloom Rec is proud and honored to expand its limits in europe connecting u this time with Greece and its electronic scene.... This time presentig you dj and producer Stamatis Mouzakitis a.k.a. TakisM...... TakisM passion with music goes back to the early 90’s where everything kicked off for him, first pair of decks & mixer and of course the very first bunch of records ……. He played in varius venues in corfu plus guest sets in major greek citys such as Athens, Thessaloniki,Ioannina,Preveza as well as Uk & London where he played in places like Club M (Luton), Indigo Bar (Clapham), Ministry Of Sound (London) Bar Mango (Reading). TakisM has produced and released tracks in various underground labels such as TakisM & Apollo 11 Project u can check out his productions here: www.beatport.com/search?query=takisM @takism www.mixcloud.com/takism www.residentadvisor.net/dj/djtakism www.facebook.com/pages/Dj-TakisM/59572930055 tracklist Sasch - Lazy Strings (Original Mix) Purple Disco Machine - My House (Original Mix) Nacho Riveros - Late Night Dub (Original Mix) Sasch - Hearts, Minds (Mario Aureo Stripped Down Remix) Faze Action - Stratus Energy (Special Disco Mix) Raha Anthony Mea-Be Alone (Anturage Remix) Solomun - YesNoMaybe (Dub Mix) Omid 16B-Heartbeats Unite (MH Studios Remix (Omid 16B Re-edit)) Britta Arnold - U See Me (Sascha Cawa, Sascha Braemer Remix) " - Incise (Original Mix) SmallTown Collective (STC) - Chilly Answer (Original Mix) Pls Enjoy Bloom Crew
Prof Pavlidis discusses the differnt types of cancer that occur during pregnancy at the 1st Cancer and Pregnancy Meeting in Milan. Cancer during pregnancy occurs in approximately one in every thousand pregnancies, although the number of cases globally is increasing. The tumour is often diagnosed late influencing both the survival of the woman and the foetus.
Genetic testing in clinical practice; interview with John Ioannidis, MD, of the University of Ioannina, Greece, and Tufts University; plus a summary of all the articles in this week's issue.
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