Podcasts about Translational neuroscience

Send us a text In this episode, Dr. Eeks is joined by neuroscientist Dr. Dwayne Godwin and cartoonist Dr. Jorge Cham, the creative duo behind Out of Your Mind, a book that makes neuroscience both fun and digestible—perfect for Nerds and Nerd Nots alike (yes, that's my podcast tagline). They kick things off with love—what it is, why we fall for some people and not others, and whether science could create a love potion that turns romance into a biochemical hostage situation. From love, they move to hate and how some people actually get addicted to hate. They'll also discuss AI—whether it could ever develop consciousness and what that might mean for humanity—before diving into addiction and the ongoing debate over how much of it is choice versus biology. They'll talk about happiness, whether money can actually buy it, and a bizarre true medical case of a man who, after a brain surgery gone wrong, was left permanently stuck in the present moment.  Finally, they'll explore what happens when we die and whether the authors ever get existentially bummed out thinking about how fragile and robotic we really are. If you like science with a side of humor and deep, slightly absurd questions, this episode is for you. Dr. Dwayne Godwin is a neuroscientist, educator, and professor in the Department of Translational Neuroscience at Wake Forest University School of Medicine. His research focuses on abnormal brain rhythms, exploring calcium channel function, epilepsy, and traumatic brain injury to develop potential treatments for neurological diseases. Beyond the lab, he is passionate about science outreach, co-creating Mind in Pictures for Scientific American Mind and contributing to blogs for the Society for Neuroscience and the Museum of the Moving Image. Dr. Jorge Cham is a Daytime Emmy-nominated, best-selling cartoonist and the creator of PHD Comics, a popular online comic strip about academia. He is the co-creator, Executive Producer, and Creative Director of Elinor Wonders Why, a top-rated PBS Kids animated series. Cham has co-authored several popular science books, including We Have No Idea: A Guide to the Unknown Universe and Frequently Asked Questions about the Universe, as well as the children's book Oliver's Great Big Universe. He also co-hosts and co-creates the hit podcast Daniel and Jorge Explain the Universe. Originally from Panama, Cham earned his Ph.D. in robotics from Stanford University and was a researcher at Caltech.You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the show

More than half of US states have legalized cannabis for recreational or medical use. Regulations on cultivation, production, and marketing vary from state to state, and most of these policies were developed without a robust public health strategy. Because it is not federally legal, Washington has provided only limited guidance to states on how to control the variety of cannabis products on the market. What's more, the dazzling arrays of gummies, vapes, and chocolates are available with much higher concentrations of THC (the psychoactive component of cannabis) than have been previously available.A recent National Academies of Sciences, Engineering, and Medicine report, Cannabis Policy Impacts Public Health and Health Equity, examines the connections between public health and marijuana legalization. On this episode, host Sara Frueh talks to Yasmin Hurd, vice-chair of the report committee, Ward-Coleman Chair of Translational Neuroscience, and director of the Addiction Institute at  Mount Sinai. They discuss the research on the complex landscape of modern cannabis products, what's known about their public health impacts, and strategies policymakers could use to minimize harms. ResourcesRead the National Academies' report, Cannabis Policy Impacts Public Health and Health Equity.Visit the Hurd Lab and Addiction Institute websites to learn more about Yasmin Hurd's work on addiction.

Rare condition research is evolving, and patient communities are driving the breakthrough. In this special Rare Disease Day episode, we explore the challenges and opportunities shaping the future of rare condition therapies. From groundbreaking gene therapy trials to the power of patient-driven research, our guests discuss how collaboration between families, clinicians, researchers, and regulators is paving the way for faster diagnoses, equitable access to treatments, and innovative approaches like nucleic acid therapies and CRISPR gene editing. With insights from Myotubular Trust, we follow the journey of family-led patient communities and their impact on advancing gene therapy for myotubular myopathy - showcasing how lived experience is shaping the future of medicine. However, while patient-driven initiatives have led to incredible progress, not every family has the time, resources, or networks to lead these research efforts. Our guests discuss initiatives like the UK Platform for Nucleic Acid Therapies (UPNAT), which aims to streamline the development of innovative treatments and ensure equitable access for everyone impacted by rare conditions. Our host Dr Ana Lisa Tavares, Clinical lead for rare disease at Genomics England, is joined by Meriel McEntagart, Clinical lead for rare disease technologies at Genomics England, Anne Lennox, Founder and CEO of Myotubular Trust and Dr Carlo Rinaldi, Professor of Molecular and Translational Neuroscience at University of Oxford. "My dream is in 5 to 10 years time, an individual with a rare disease is identified in the clinic, perhaps even before symptoms have manifested. And at that exact time, the day of the diagnosis becomes also a day of hope, in a way, where immediately the researcher that sent the genetics lab flags that specific variant or specific mutations. We know exactly which is the best genetic therapy to go after." You can download the transcript, or read it below. Ana Lisa: Welcome to Behind the Genes.    [Music plays]  Anne: What we've understood is that the knowledge and experience of families and patients is even more vital than we've all been going on about for a long time. Because the issue of there being a liver complication in myotubular myopathy has been hiding in plain sight all this time, because if you asked any family, they would tell you, “Yes, my son has had the odd liver result.”  There were some very serious liver complications but everybody thought that was a minor issue, but if we are able to engage the people who live with the disease and the people who observe the disease at a much more fundamental level we may be able to see more about what these rare genes are doing.  [Music plays]  Ana Lisa: My name is Ana Lisa Tavares, I'm Clinical Lead for Rare Disease research at Genomics England and your host for this episode of Behind the Genes. Today I'm joined by Anne Lennox, Founder and CEO of the Myotubular Trust, Dr Meriel McEntagart, an NHS consultant and Clinical Lead for Rare Disease Technologies at Genomics England, and Dr Carlo Rinaldi, Professor of Molecular and Translational Neuroscience at the University of Oxford.    Today we'll be hearing about the importance of involving the patient community, particularly as new rare therapies are developed, and discussing the forward-facing work that's happening that could have potential to unlock novel treatments for many rare conditions.  If you enjoy today's episode we'd love your support. Please like, share and rate us on wherever you listen to your podcasts. Thank you so much for joining me today.  Please could you introduce yourselves.   Anne: I'm Anne Lennox, I'm one of the founders of the Myotubular Trust, a charity that raises research funds for and supports families affected by the rare genetic neuromuscular disorder myotubular myopathy.  Meriel: I'm Meriel McEntagart, I'm a consultant in clinical genetics in the NHS and I have a special interest in neurogenic and neuromuscular conditions.  Carlo: Hi, I'm Carlo Rinaldi, I'm Professor of Molecular and Translational Neuroscience at the University of Oxford. I'm a clinician scientist juggling my time between the clinic and the lab where we try to understand mechanisms of diseases to develop treatments for these conditions.  And I'm also here as a representative of the UK Platform for Nucleic Acid Therapies, UPNAT. Thanks for your invitation, I'm very pleased to be here.  Ana Lisa: Thank you. Meriel, I'd love you to tell us a bit about your work and how you met Anne, how did this story start?  Meriel: Thank you. Well prior to being a consultant in clinical genetics, I spent 2 years as a clinical research fellow in neuromuscular conditions, and as part of that training I worked on a project where the gene for myotubular myopathy had just been identified, and so there was a big international effort to try and come up with sort of a registry of all the genetic variants that had been found as well as all the clinical symptoms that the affected patients had, and then do kind of a correlation of the particular variant mutation with symptoms.   I worked when I was training to be a clinical geneticist because of my interest in neuromuscular conditions so when I eventually became a consultant at St George's Hospital I was actually interviewed by the Professor of Paediatrics and he knew Anne and her son, when Anne was looking for more information about the condition he suggested that perhaps I might be a good person for Anne to talk to.  Ana Lisa: Thank you. Interesting connections. Anne, can you tell us your story and how this led you to found the Myotubular Trust?  Anne: Yes, thanks Ana-Lisa.  Well, as many families will tell you when they're newly diagnosed with a rare disease, you go from knowing nothing about a condition to being one of the few deep experts in that condition because there are so few deep experts. So this happened to us in 2003 when our son, Tom, was born, and when he was born he was floppy and his Apgar scores, the scores they do on new-born babies, were pretty poor, and before long we knew that it was more than just momentary issues at birth.  And, cutting a very long story short, 5 weeks later he was diagnosed with this very rare neuromuscular genetic disorder that we didn't know we had in the family.  We were told that this was a very serious diagnosis.    At that time – more than 20 years ago – over 80% of those boys didn't make it to their first birthday and the stark statistic we had in our head a lot was that only 1% made it past the age of 10. And that has changed due to better ventilator and breathing equipment, etc, but at the time we expected that he might not make it to his first birthday.    We were very lucky, we had Tom longer than one year, we had him for nearly 4 years, 4 very lovely years where it was tough, but he was a really lovely member of our family.  Despite being really weak he managed to be incredibly cheeky and bossy, and he was a great little brother for his big sister. We were also very lucky that he was being looked after by Professor Francesco Muntoni, who is Head of the Paediatric Neuromuscular Service at Great Ormond Street. And, like Carlo, he is a clinical researcher and actually that I found to be amazing as a family member because you knew what was happening out there and Professor Muntoni, other than living with the reality day to day you want to know where things are going.    We began to realise that back then 20 years ago the more common rare neuromuscular diseases were finally beginning to get some fundamental research funds, like Duchenne, spinal muscular atrophy, and Professor Muntoni was very good at explaining to lay non-scientific parents like us that one day the technologies that would lead to a cure, that would re-engage proteins for other conditions and would translate down eventually into the possibility of replacing myotubularin, which is the protein not being produced or not being produced enough in myotubular myopathy. And then we began to understand actually what the barriers to that would be, that translating developments in more common, or let's say more prevalent conditions, would be hard to do without some translation research being done; you could not just not lag years behind, you could lag decades behind if you haven't done some other work.    So, I met Wendy Hughes, another mother, of a boy called Zak who was a few years older than Tom, and these were the days before social media, and it was amazing to be in contact with another family going through something similar and we had great conversations. But then they were also looked after by Professor Muntoni and we particularly began to develop the idea as 2 families that we might be able to raise some research funds towards this concept of keeping pace with the scientific developments.  And then we discovered there was no charity we could channel those funds through. Even the umbrella body for neuromuscular diseases who were covering 30 to 40 conditions, frankly, they just couldn't trickle their funding down into investing in every neuromuscular disease, and slowly but surely it dawned on us that if we did want to make that difference we were going to have to set up our own charity.   So that's what we eventually did and back in 2006, we founded what was actually the first charity in Europe dedicated to myotubular myopathy – luckily, more have come along since – and we were dedicated to raising research funding. In fact, it wasn't our goal to set up another charity but around that time, about a year in, we happened to go to a meeting where the Head of the MRC, the Medical Research Council, was giving a talk and he said that in the last few years the MRC had begun to really realise that they couldn't cure everything, that they couldn't cure the diseases that would be cured in the next millennium from a top down perspective. There had to be a trick, there had to be a bottom up as well, because that was the only way this was going to happen. And I have to say that that was a really reassuring moment in time for us to realise that we weren't just chasing pipe dreams and trying to do something impossible, that there was a role for us.    Ana Lisa: I think it would be really interesting for people to hear your story and the amazing set-up and fundraising that you've done, and at the same time it would be really good for us to reflect on how this isn't feasible for every patient and every family and how we're going to need to work cooperatively to move forwards with rare therapies.  Anne: When we explored the idea with Professor Muntoni and Meriel and others about setting up a charity one of the really reassuring things that Professor Muntoni got across to us was that this wasn't about raising the millions and millions it would take to fund clinical trials but the issue in the rare disease space was funding the proof of principle work, the work where you take a scientist's hypothesis and take it over the line, and the rarer the disease, the less places there are for a scientist to take those ideas. And the example he gave us was a piece of research like that might cost a hundred to a couple of hundred thousand, if you fund a piece of work like that and if it is successful, if the scientist's principle gets proven, then behind you it's much easier for the bigger muscle disease charities to also invest in it. It's harder for them to spread their money across all the very rare diseases hypothesis out there, but if you've helped a scientist get over the line they'll come in behind you and then they won't be the ones who fund the tens of millions that it takes to run a clinical trial.    If it's got potential, then that's where the commercial world comes in, and that's where the biotechs come in. So he'd given the example of if you spent £ten0,000 on a piece of research and it actually is proven, in behind you will come the bigger charities that would put in the million that takes it to the next phase, and in behind them will come the bio-checks that'll provide biotechs that'll provide the tens of millions.    And then, you know, a lot of what happens relies on serendipity as well, we know that, and you could easily run away with the idea that you made everything happen but you don't, you stand on the shoulders of others. And our very first grant application in our first grant round, which received extraordinary peer review for how excellent the application was, was a £100,000 project for a 3-year project that had gene therapy at the core of it by a researcher called Dr Ana Buj Bello at Généthon in Paris. This piece of research was so promising that 18 months in she and another researcher were able to raise $780,000 and, as Professor Muntoni predicted, from the French muscle disease charity AFM and the American muscle diseases charity MDA.  And 18 months into that 3 years it was so promising that a biotech company was started up with $30 million funding, literally just on her work.    So that doesn't always happen but, as Professor Muntoni explained, our job was not that $30 million, our job was that first £100,000, and our job was also to make ourselves known to the people in the neuromuscular field.  If you have lab time, if you have research time and you have a choice where you're putting it there is a place you can go to for a myotubular myopathy related grant application, so it's not just that this will come to us out of the blue, people will have done prior work, and our existence makes it worth their while, hopefully, to have done that prior work.  Ana Lisa: That's an amazing story how you've set up this charity and how successful that first application for gene therapy was. I'd love to hear more about that gene therapy and did it get to the clinic and to hear that story from you.  Because I think there are a lot of learnings and it's really important that the first patients who are treated, the first families that are involved, the researchers who start researching in this area, the first treatments lead the way and we learn for all the other treatments for all the other rare conditions that we hope and that together as a community we can share these learnings.  Anne: Yeah. I sometimes describe it a bit like going out into space. When you see a rocket going off look at how many people are behind and the amount of work that's been done, the degree of detail that's managed, and then you go out into space and there are a whole load of unknowns, and you can't account for all of them.  Who knows what's out there in this sphere.  But the amount of preparation, it feels similar to me now, looking back.  We were so idealistic at the beginning.  Our grant to Dr Buj Bello was 2008 and actually it is a really fast time in, the first child was dosed in the gene therapy trial in September 2017.  Ana Lisa: So, we're talking less than 1 years.  Anne: Yeah. And in the meantime obviously as a charity we're also funding other proof of principle research. One of the founding principles of the charity was to have a really excellent peer review process and scientific advisory board so that we wouldn't get carried away with excitement about one lab, one research team, that everything would always come back to peer review and would be looked at coldly, objectively. I don't know how many times I've sat in a scientific advisory board meeting with my fingers crossed hoping that a certain application would get through because it looked wonderful to me, and then the peer review comes back and there are things you just don't know as a patient organisation. So, yes, in those 9 years we were also funding other work.  Ana Lisa: You've just given an interesting perspective on sharing the learnings between the scientists, clinicians, the experts in a particular condition, if you like, and the families, and I'd be really interested to hear your views on what's been learnt about how families and the patient community can also teach the clinical and scientific community.  Anne: So, the first child was dosed in September 2017 and by the World Muscle Society Conference 2 years later in October 2019 the biotech had some fantastic results to show. Children who had been 24-hour ventilated were now ventilator-free, which, unless you know what it's like to have somebody in front of you who's ventilator-dependent, the idea that they could become ventilator-free is just extraordinary.    However, one of the things we've learnt about gene therapy is that we are going out into space so there are extraordinary things to be found, and extraordinary results are possible, as is evidenced here, but there is so much that we don't know once we are dealing with gene therapy. So unfortunately, in May, June and August of 2020, 3 little boys died on the clinical trial. So we have a clinical trial where the most extraordinary results are possible, and the worst results are possible, and both of those things are down to the gene…  What we discovered and what is still being uncovered and discovered is that myotubular myopathy is not just a neuromuscular disorder, it is a disorder of the liver too, and these children didn't die of an immune response, which is what everybody assumes is going to happen in these trials, they died of liver complications.    And one of the things that has come out of that, well, 2 sides to that. Number one is that it is extraordinary that we have found a treatment that makes every single muscle cell in the body pick up the protein that was missing and produce that protein, but also what we've understood is that the knowledge and experience of families and patients is even more vital than we've all been going on about for a long time. Because the issue of there being a liver complication in myotubular myopathy has been hiding in plain sight all this time, because if you asked any family they would tell you, “Yes, my son has had the odd liver result, yes.”    We could see something that looked like it was not that relevant because it was outside the big picture of the disease, which was about breathing and walking and muscles, but actually there was this thing going on at the same time where the children had liver complications. There were some very serious liver complications but everybody thought that was a minor issue but if we are able to engage the people who live with the disease and the people who observe the disease at a much more fundamental level we may be able to see more about what these rare genes are doing.  Ana Lisa: Yeah, thank you very much for sharing such a moving story and with such powerful lessons for the whole community about how we listen to the expertise that families have about their condition, and also I think the really important point about how we tackle the research funding so that we're including and sharing learnings from the conditions that are initially studied in greater depth, and we hope that many more conditions will be better understood and more treatments found and that actually the learnings from these first gene therapy trials will really help inform future trials, not just for gene therapies but also for many other novel therapies that are being developed.  [Music plays] If you're enjoying what you've heard today, and you'd like to hear some more great tales from the genomics coalface, why don't you join us on The Road to Genome podcast. Where our host Helen Bethel, chats to the professionals, experts and patients involved in genomics today. In our new series, Helen talks to a fantastic array of guests, including the rapping consultant, clinical geneticist, Professor Julian Barwell, about Fragile X syndrome, cancer genomics and a holistic approach to his practice - a genuine mic-drop of an interview. The Road to Genome is available wherever you get your podcasts. [Music plays] Ana Lisa: Carlo, I would really like to come to you about some of the initiatives that are happening in the UK, and particularly it would be really interesting to hear about the UK Platform for Nucleic Acid Therapies as a sort of shining example of trying to do something at a national scale across potentially many different rare conditions.    Carlo: Thanks, Ana-Lisa. Thanks very much, Anne, for sharing your fantastic story. I mean, I just want to iterate that as clinician scientists we do constantly learn from experiences and constantly learn from you, from the patient community, and this is absolutely valuable to push the boundary. And I really liked your vision of a rocket being launched in space and I would imagine that this is a similar situation here. So, we are facing a major challenge. So, there is over 7,000 rare diseases in the world and with improvements of genetic diagnosis this is only increasing. So, in a way rare diseases is the ultimate frontier of personalised medicine and this poses incredible challenges.   So, you mentioned the bottom-up approach and the top-down approach and in a way, both are absolutely necessary. So your story is a fantastic story but also makes me think of all the other families where they don't share perhaps the same spirit, you know, they are in areas of the world that are not as well connected or informed, where patient community simply cannot be ‘nucleated', let's say, around the family. So, there is definitely an issue of inclusivity and fair access.    So, what we're trying to do at UPNAT, which is the UK Platform for Nucleic Acid Therapy, is to try to streamline the development both at preclinical and clinical level of nucleic acid therapies. So, we'll start with antisense oligonucleotides just because those are the molecules of the class of drugs that are most ‘mature', let's say, in clinic. So, there are several antisense oligonucleotides already approved in the clinic, we know that they are reasonably safe, we understand them quite well, but of course the aspiration is to then progress into other forms of gene therapy, including gene editing approaches, for example.   And one of the activities that I'm involved, together with Professor Muntoni, is to try to streamline the regulatory process of such therapies and in particular curate a registry of, for example, side effects associated with nucleic acid therapy in the real world, and you would be surprised that this is something that is not yet available.  And the point is exactly that, it's trying to understand and learn from previous mistakes perhaps or previous experiences more in general.    And this is very much in synergy with other activities in the UK in the rare disease domain.  I'm thinking of the Rare Disease Therapy Launchpad, I'm thinking of the Oxford Harrington Centre, I am thinking of the recently funded MRC CoRE in Therapeutic Genomics. These are all very synergistic. Our point is we want to try to amplify the voice of the patient, the voice of the clinicians working on rare disease, and we want to systematise. Because of course one of the risks of rare disease therapies is the fragmentation that we do all these things in isolation. And I would argue that the UK at the moment leveraging on the relatively flexible and independent regulatory agencies, such as the MHRA, on the enormous amount of genetics data available through Genomics England, and of course the centralised healthcare system, such as the NHS, is really probably the best place in the world to do research in the rare disease area, and probably I'm allowed to say it because I'm a non-UK native.       Ana Lisa: Thank you, that's a brilliant perspective, Carlo, and across all the different therapeutic initiatives that you're involved with. And, Carlo, presumably - we're all hoping - these different initiatives will actually lead to ultimately a bigger scaling as more and more novel therapies that target both our RNA and DNA and actually are working, I guess further upstream in the pathway.    So classically in the past it's been necessary to work out all the underlying biology, find a druggable target somewhere in that pathway and then get a larger enough clinical trial, which can be nearly impossible with many of the rare and ultra-rare conditions or even, as you've said, the sub-setting down of more common condition into rarer subtypes that perhaps can be treated in different ways.  And with the many new different treatments on the horizon, ASO therapies, as you've said, is a place that's rapidly expanding, and also crisper gene editing. I'd be really interested to hear your reflections on how this might scale and also how it might extend to other new treatments.  Carlo: Yeah, that's exactly the right word, ‘scaling up'. I mean, there will be of course very unique challenges to every single rare disease but I would argue that with genetic therapies, such as ASOs or crisper gene editing, the amount of functional work that you need to do in a lab to prove yourself and the scientific community that this is the right approach to go for can be certainly very important but can be less just because you're addressing very directly because of the disease.    And then there are commonalities to all these approaches and possibly, you know, a platform approach type of regulatory approval might serve in that regard. You know, if you are using the same chemistry of these antisense oligonucleotides and, you know, similar doses, in a way the amount of work that you need to produce to again make sure that the approach is indeed a safe approach and an effective approach might be also reduced.    I would say that there are also challenges on other aspects of course, as you were saying, Ana-Lisa. Certainly the typical or standard randomised placebo control trial that is the standard and ultimate trial that we use in a clinical setting to prove that a molecule is better than a placebo is many times in the context of rare diseases simply not possible, so we need to think of other ways to prove that a drug is safe and is effective.   This is something that we all collectively as a scientific community are trying to address, and the alliance with the regulatory agencies, such as the MHRA, and you said that you have found your interaction with the MHRA very positive, and I can tell you exactly the same. So we are all trying to go for the same goal, effectively, so trying to find a way to systematise, platformise these sort of approaches. And I guess starting with antisense oligonucleotides is really the right place to go because it's a class of drugs that we have known for a long time, and we know it can work.  Ana Lisa: Meriel, can you tell us a little about the National Genomic Research Library at Genomics England and how this could link with initiatives to find many more patients as new treatments become available for rare and ultra-rare conditions?  Meriel: Yes, I think what's wonderful now is actually that what we're really trying to do is give everybody the opportunity to have their rare condition specifically diagnosed at the molecular level, and the way in which that is being done is by offering whole genome sequencing in the NHS currently in England but to all patients with rare diseases.    And so, it's about trying to establish their diagnosis. And as well as that, even if the diagnosis isn't definitely made at the first pass when the clinical scientists look at the data, because the whole genome has been sequenced, actually all that information about their genome, if they consent, can then be put into the National Genomics Research Library.  And that is a fantastic resource for national and international researchers who get approved to work in this trusted research environment to make new disease gene discoveries and identify these diagnoses for patients.  What's also offered by Genomics England as well is when the National Genomics Library data results in a new publication, the discovery of a new gene or perhaps a new molecular mechanism that causes a disease we already know about, that feeds back into the diagnostic discovery pathway within Genomics England back onto the diagnostic side of all the data.    So, patients who may have had genetic testing previously using whole genome sequencing where they've, if you like, had their sequencing done before the diagnosis was sort of known about, will also be picked up. And so, what this is really doing is trying to kind of give this really equal platform for everybody having testing to all have the same opportunity to have their diagnosis made, either on the diagnostic side or with research.  Ana Lisa: So, sort of on a cohort-wide scale as new discoveries are made and published you can go back and find those patients that may actually have that diagnosis and get it back to them, which is brilliant.  Meriel: Exactly. And this speeds up the whole process of getting these diagnoses back to people. So on a regular basis in the NHS, we will get feedback from the Diagnostic Discovery Pathway about “Here's some patients who you requested whole genome sequencing from a number of years ago and actually now we think we know what the particular molecular condition is.”  And so, it's key of course for our patients with rare conditions to make that molecular diagnosis because then we're able to have them identified for our colleagues who are doing this ground-breaking research trying to bring therapies for these rare conditions.  Ana Lisa: Thank you. And I hope that, as currently, if a novel genetic mechanism, as you've just described, is identified that could explain a rare condition that those patients can be found and they can receive that diagnosis, even many years later, and hopefully as novel treatments become available and say there's a chance to individualise ASO therapies, for example, to start with, that one could also go and look for patients with particular variants that could be amenable potentially to that treatment. And that's really sort of exciting that one could look for those patients across England, irrespective of which clinic they're under, which specialist they're under, and I think that could be really powerful as new treatments develop. I suppose, Meriel, if somebody comes to see you now in clinic are things different?  Meriel: Well, I think one of the things for me when patients come to clinic now is we might have an idea about what we think their condition is, maybe even we think it's a specific gene. And we can offer whole genome sequencing and so it's not just the way we used to do things before by looking just at the coding regions of the gene, we can find more unusual ways in which the gene can be perturbed using whole genome sequencing.  But let's say we don't make the diagnosis. I encourage my patients, if they're comfortable with it, to join the National Genomics Research Library, because really it's been incredibly productive seeing the new genetic discoveries that are coming out of that, but as well I say to them, even if we don't get the diagnosis the first time round when we look at the data, actually this is a constant cycle of relooking at their data, either if they're in the NGRL or as well on the Diagnostic Discovery Pathway side of the service that's run by Genomics England. So yeah, I feel like it's a very big difference; they don't have to keep coming every year and saying, “Is there a new test?” because actually they've had an excellent test, it's just developing our skills to really analyse it well.  Ana Lisa: Yes, and our knowledge, the technology and the skills keep evolving, certainly.  And I think one of the things that I'm sort of hearing from this conversation is that balance of hope and realism, Carlo we were talking about earlier how you need all the pieces of the puzzle to be lined up - so the regulatory agency, the clinicians, all the preclinical work has to have been done, monitoring afterwards for side effects - every piece of the puzzle has to be lined up for a new treatment to make it to a patient.    And, Anne, I'd like to come back to you because we've talked about this before, how one balances these messages of optimism and hope which are needed for bringing everybody together as a community to crack some of these very difficult challenges highlighted by treatments for rare and ultra-rare conditions and at the same time the need for realism, a balance conversation.  Anne: Yeah, that was one of our big learnings through the gene therapy trial and other trials we've had in the condition. As a rare disease charity, you do everything. You know, my title is CEO, but I tell people that's Chief Everything Officer because there's only a few of you and you do everything. So, you go and you lead the London Hope Walk and you also are a layperson on the Scientific Advisory Board and you also send out the emails about grants... And so, you could easily as a small rare disease charity conflate different communication messages because you're in a certain mode.  And so we have been from the early days in the mode of raising hope for people to say, “Look, we can make a difference as a patient community, we could raise funds, we might be able to move things forward, you've got the power to make a difference if you want to.” That's one set of hope.  And it's not dreamlike hope, we're linked to the reality of there are great breakthroughs.  So, you know, in the world of spinal muscular atrophy these clinical trials have led somewhere very quickly, so we're not selling false hope, we're talking about the difference we can make.    But then as soon as you flip into “There's a clinical trial being run” that's a completely different type of communication and you cannot conflate that message with the previous message.  And we always say to everybody, “We're your team, we're a family, we're a team, we all help each other.  When you are considering joining a clinical trial your team is the clinical trial team.    The other team does other things for you but the people you need to work with and ask hard questions of and listen hard to, that's your clinical trial team led by the principal investigator because then you're in that with them. And, you know, the reality of the fact that many, many clinical trials don't work as we wish they would be and the decision you make for your child, your baby, your little one, to join a clinical trial… because that's what it comes down to in our disease, has to be made with that team, not the team that's selling you a fundraising event. It's worth reminding rare disease patient organisations we're wearing different hats and the hope and the realism are different tracks you have to go down.    But at the same time as being realistic you also have to keep remembering that there is still grounds for hope, we are moving forward. And 21 years ago, when Tom was born the idea that you would be able to get all of the muscles in the body to switch back on – putting it in lay terms – seemed like a bit dream. Well, that is what has happened in the gene therapy clinical trial, we just have to now make it safer and understand more about what we're dealing with. So, the 2 things, the hope and the realism, do exist side by side.  Ana Lisa: I think that perfectly encapsulates a lot of the messages around rare disease therapies where there's such hope that novel treatments will really target directly the DNA or RNA to potentially correct the problem across many different rare conditions and therefore actually making treatments one day suddenly available to a much, much bigger population of people with rare conditions than we could've dreamt of 20 years ago or perhaps now, and at the same time this massive need to work cooperatively to all make this as fair, as equitable. Not everybody is going to have the opportunity to fundraise massively to be an expert about their condition, and the importance of sharing these learnings and also really, really listening to the patient community and really, as Carlo was saying, keeping track of side effects, having registries/databases to share these is going to be incredibly important.  [Music plays]  Ana Lisa:  Anne, can you tell us a little about your reflections on equity from the patient community perspective?  Anne: Well I mentioned serendipity early and one of the aspects of serendipity that played into our favour for setting up the Myotubular Trust was that by hook or by crook Wendy Hughes, who set up the charity with me, and I were both able to devote time at that period of our lives to setting up a charity. When my husband, Andrew, and I were told that Tom would more than likely die before his first birthday, one of the decisions we made as a family was that he would never not be with a parent, we would always have someone around, and that kind of meant someone had to give up a full-time job and that was me.  We thought, “If Tom has a few scarce months on the planet, we'll be with him.” And then when Tom lived to be nearly 4, as a family we got used to living on one salary and we were very lucky that we could pay the mortgage that way and run our family that way and eventually that meant I had the time to run the charity.    That doesn't happen that easily, that's a tall order, particularly when you have somebody in the family who has such high needs. And one of the things that I have often thought about is that in the rare disease space we could do with a different funding model for rare disease charities, we could, in an ideal world I have this nirvana that I imagine where there's a fund that you can apply to that is contributed to by the people who make profits out of finding rare disease cures - so the pharmaceutical companies and the biotechs - and there's a fund that they contribute to and that if you have a rare disease and you are willing to set up an organisation that supports families, that raises research funds, that provides a way of hearing the patient voice, then you could apply to that for running cost funds and then you'd be able to run this charity. And then you wouldn't have to rely on whether you live in an area where people will raise money for you or…  We were very lucky that we came across a few great benefactors who would give us money for running the charity, which is actually how we fund it.    All the research money we raise goes 100% into research, not a penny of it goes towards running costs because we have serendipitously found people who will be benefactors for the charity, but we're relying on a lot of good luck for that kind of model to work. And when you look at how much profit is made from developing rare disease treatments and cures – which is fine because that's what puts the passion and that gets people working on it – then why not have an advance fund to run rare disease charities? One of my nirvana dreams.  Ana Lisa: It's good to dream. Indeed, my hope is that there will be some amazing shining examples that lead the way that open doors, make things possible, prove that something can work and how and that then that will enable many other treatments for many additional rare conditions to be added in so that if you've learnt how this particular treatment modality works for this rare condition and there was funding behind it and everything else that's needed that then you can, the learning from that, I'm going to use the word ‘tweak', which sounds minor and could be very major but actually the concept that you can then tweak all those learnings and findings so that that same type of treatment modality could be adapted to treat somebody else with a different rare condition in a different location would be absolutely incredible and really powerful, given that if something like 85% of rare conditions affect less than one in a million people it's not going to be feasible to use the same strategies that have been used in the past for very common conditions.    One of the other big barriers is the cost of developing treatment for ultra-rare conditions.  Where it's a small number of patients that you have and therefore all the challenges that come with monitoring, checking for efficacy, monitoring safety and ultimately funding the challenges are much greater, however if some of these treatment modalities are also going to be used to treat common conditions it might be that actually there's a lot more cross-talk between the nano-rare, ultra-rare, rare and common conditions and that we can share a lot of that learning. I'd love to hear from each of you where you hope we will be for rare disease and rare therapies.  Carlo: Well my dream is that in 5 to 10 years' time an individual with a rare disease is identified in the clinic, perhaps even before symptoms have manifested, and at that exact time the day of the diagnosis becomes also a day of hope in a way where immediately the researcher, the centre, genetics lab, flags that there are the specific mutations, we know exactly which is the best genetic therapy to go after, antisense oligonucleotides as opposed to CRISPR editing, and a path forward, both at the preclinical and clinical level, to demonstrate and to cure these patients eventually is already laid out in front of the patient.  So, transforming the day of their diagnosis as a day of hope, this is my dream with the next ten years.  Ana Lisa: Thank you, that's a wonderful dream. Meriel, can I come to you?  Meriel: Yes, I think I just want to echo Carlo.  We've had great developments and progress with getting whole genome sequencing into the NHS for testing but what we really need is for it to be fast and efficient and getting those diagnoses established quickly. And we have had that set up now and we're really getting there in terms of speed, but then what we need is exactly what's the next step and actually structure like UPNAT that are developing these processes that we can then say to the patient, “And from there, now that we've established your diagnosis, this is what we have options to offer.”  Ana Lisa: Brilliant. And presumably that if the diagnosis isn't achieved now there is a hope that it will be achieved in the future as well. Anne...  Anne: Well, stepping one hundred per cent into the patient's shoes rather than the scientific side that we don't so much influence....  stepping in the patient's shoes, in 5 years' time I would absolutely love it if we were in a situation where all the parties that have come to the table looking at a therapy or in the earlier research genuinely want to bring the patient voice into the room. As Carlo talked about, there's even going to be more and more and more of these rare diseases, then those voices, those few people who have experience of it, they may be able to shed light on something. Maybe even sometimes don't even know it's a fact that they know but that were brought to the table as passionately as everything else is brought to the table.  [Music plays]  Ana Lisa: We'll wrap up there. Thank you so much to our guests, Anne Lennox, Carlo Rinaldi and Meriel McEntagart, for joining me today as we discuss the collaborative power of working together and look to the future of rare therapies that could have the potential to unlock treatments for many rare conditions. If you'd like to hear more like this, please subscribe to Behind the Genes on your favourite podcast app.  Thank you for listening.  I've been your host, Ana-Lisa Tavares. This podcast was edited by Bill Griffin at Ventoux Digital and produced by Naimah Callachand.  

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.Galapagos is set to split into two entities by mid-2025, creating a new innovative medicines specialist and a cell therapy company. Novo has invested $4.6 billion to expand its deal with Valo, aiming to maintain leadership in the cardiometabolic space. Tenvie, supported by venture partners, will be focusing on developing brain-penetrant small molecules for neurological and metabolic diseases.The trend of licensing deals in the pharmaceutical industry is on the rise, with experts debating whether it is a sign of desperation or a crucial part of the biotech ecosystem. Roche is in the final stages of acquiring Poseida for up to $1.5 billion, while Cassava has had to lay off a third of its staff following a setback in an Alzheimer's drug trial. Major pharmaceutical companies are looking towards China for potential deal opportunities, despite regulatory uncertainty in the region. The FDA is considering setting a bar for weight-loss therapies as the obesity space continues to heat up. Looking ahead to 2025, there is a cautiously optimistic outlook for the biopharma industry, with predictions of increased M&A activity leading up to key events like the J.P. Morgan Healthcare Conference and important FDA decisions.As licensing deals become more common in the biotech industry, big pharma companies are exploring partnerships in China. The industry is gearing up for the J.P. Morgan Healthcare Conference with a sense of uncertainty after M&A activity did not meet expectations in 2024. Biospace's NextGen Class of 2025 features startups focusing on emerging trends in biopharma, attracting investments from major players.Companies like Roche, Merck, and Novo are making significant moves in the biopharma space, shaping the industry landscape. Job opportunities are available in various sectors, including positions like Chief of Staff and Senior Director in IT and Translational Neuroscience. Biospace is working on enhancing user experience by personalizing emails based on individual preferences.Thank you for tuning in to Pharma and Biotech Daily, where we bring you the latest updates and insights from the world of pharmaceuticals and biotechnology.

DOI: 10.13056/acamh.35725 In this In Conversation Podcast, Clara Faria is joined by Tanatswa Chikaura, a mental health researcher and advocate, Founder and Director of Ndinewe Foundation, and PhD candidate in the Department of Psychiatry in the University of Cambridge. Tanatswa's research interests include suicide prevention, trauma, and mental health among autistic children and adults. Tanatswa was acknowledged in 2023 with a Diana Award for her mental health advocacy work. The focus of this podcast is on Tanatswa's research journey, her mental health advocacy work, and how she conciliates both. Discussion points include: The experience of moving from Zimbabwe to the UK to do an MPhil in Translational Neuroscience at Cambridge, and the process of adapting to a new country whilst studying. Tanatswa's interest in studying anxiety and autism. Tips for choosing a research topic and supervisor when applying for PhDs. Insight into the Ndinewe Foundation, including what inspired its creation, the main goals and its achievements so far. Advice for young people from low- and middle- income countries who want to apply for postgraduate training in the UK. #ListenLearnLike

Judith Orloff, UCLA clinical psychiatrist and author of The Genius of Empathy: Practical Skills to Heal Your Sensitive Self, Your Relationships, and the World, explains that empathy is what connects us. It’s the ability to care, to listen, and to open our hearts. The practice of empathy, Orloff says, is a simple yet “precious gift” and that displaying empathy is  the “best of who we are.” Orloff also says being empathetic is “a way we can save our world because empathy is the key element in reaching out to people, even if you disagree with them, even if you don't like them, it allows you to establish accord with them.” In addition, Orloff says, “when you're open to empathy, all kinds of good things can happen to your body. There's something called the Mother Teresa effect, where it's been shown that if you witness an act of empathy, and I were to draw your blood, it would show that your immunity would go up immediately. And what that says to me is that just alone, watching empathy can increase our immunity and make us healthier.” Zachary Wallmark, an associate professor of musicology and with the Center for Translational Neuroscience at the University of Oregon, talks about his research on the intersection of music and empathy. Wallmark has  observed, through magnetic imagining, how listening to music relates to social cognition and empathy. “Empathy,” Wallmark says, “produces a very distinctive neural signature in the brain when folks are listening to music. Empathy modulates music processing in areas of the brain that are associated with cognitive control, with social processing, with reward, and with emotion.”  Through music, Wallmark says, we can “explore our own identity, learn about others, bond with others. So music can be useful in social cohesion, bonding, [and] it can help coordinate group activity. It can also demarcate social boundaries, who is like us and who is different from us.” In her book The Genius of Empathy: Practical Skills to Heal Your Sensitive Self, Your Relationships, and the World, author Judith Orloff says  “If you're having difficulties with your relationships, just try this gift-- just to listen, with your eyes, with your voice, with your heart -  it's such a gift and it helps people feel seen and heard and valued, which is the point of empathy.”  Judith Orloff, pictured here, says “in my life, the most important thing to me is connection, and love and understanding. That is what gives me the most meaning Whether it's with nature, with human beings, with animals - empathy allows us that opportunity to connect with our human kind and everything about this life that we've been given.”  Photo courtesy of Bob Riha Zachery Wallmark, pictured here, says “music can create a kind of playground to try on, in a fantasy sense, different types of emotional reactions. You can be a different person, you can experience things that you're not experiencing in your … normal life." Photo by Kim Leeson. Delve deeper into life, philosophy, and what makes us human by joining the Life Examined discussion group on Facebook.

Steve Davis This week on the podcast, I'm thrilled to bring you my conversation with Steve Davis, otherwise known as my dad!  Dad and I are very close and this is really an informal conversation where I wanted to ask dad some of the biggest things he's learned about living well as he recently turned 75, despite appearing as though he is in his 50s.  Professor Stephen Davis AO is the Professor of Translational Neuroscience at the University of Melbourne, Director of the Melbourne Brain Centre at the Royal Melbourne Hospital and Co-Chair of the Australian Stroke Alliance.   His research is focussed on acute therapy for both ischemic stroke and intracerebral hemorrhage, particularly the use of advanced imaging in selection of therapy. He is a consulting editor for Stroke and serves on editorial boards of the International Journal of Stroke, the European Stroke Journal and the Journal of Clinical Neuroscience. Learn more about Dad's career to date check out Episode 200. Our Sponsor Neon Treehouse is our major sponsor and partner in production. They are the go to full service digital marketing agency in Australia, for bright and imaginative solutions.  Promotional Partnerships Like what we are serving up on Humans of Purpose? Our promotional campaigns have delivered great marketing and sales outcomes and ROI for our partners to date.  Whether you're seeking a 1-month, 2-month or season sponsorship, follow the flow below to become a partner before we run out of our remaining promotional slots for 2024.  Click Here to learn more about collaborating on a custom campaign package. Ready to partner? Just complete this short Partner Enquiry Form and we'll be in touch. Gold Membership Want a premium listening experience that directly supports us to keep making the podcast?  Join current members Michael, Pravati, Noel, Kathy, Andrew 1, Andrew 2, Chris, Nikki, Margaret, Ben, Misha, Sarah and Geoff and enjoy our range of member benefits:  Premium dedicated podcast feed Removal of all three ads per episode Early access to all episodes Full transcripts of all episodes Brokered intros to all podcast guests Ask me anything page access To take up this great offer, just head to our Gold Member page today.

Recently, NY1's Errol Louis moderated a panel discussion, hosted by Vital City and the Craig Newmark Graduate School of Journalism at CUNY, on New York's rocky rollout of legalized cannabis — examining what policies and practices are needed to create a viable market moving forward.  Louis was joined for the discussion by Rosalind Adams, a reporter at The City, Dr. Yasmin Hurd, Ward-Coleman chair of Translational Neuroscience and the director of the Addiction Institute at Mount Sinai, and Alfredo Angueira, chief compliance officer and founding partner of CONBUD, the first legal cannabis dispensary run and operated by formerly incarcerated individuals. Join the conversation, weigh in on Twitter using the hashtag #NY1YouDecide or give us a call at 212-379-3440 and leave a message. Or send an email to YourStoryNY1@charter.com.

Here Dr Seranova talks about the supplements she takes, and a couple that she does not. Also sleeping and a hack for getting better deep sleep. The new brain supplement that Dr Seranova talks about is now available. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova talks about her diet and exercise and how she thinks about these. Some links are affiliate links so we will earn a commission when they are used to purchase products. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neuron Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Dr. Yasmin Hurd is the Director of the Addiction Institute within the Mount Sinai Behavioral Health System as well as the Ward Coleman Chair of Translational Neuroscience and Professor of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai in New York. Dr. Hurd is an internationally renowned neuroscientist whose translational research examines the neurobiology of drug abuse and related psychiatric disorders. Her research exploring the neurobiological effects of cannabis and heroin has significantly shaped the field. Using multidisciplinary research approaches, her research has provided unique insights into the impact of developmental cannabis exposure and epigenetic mechanisms underlying the drug's protracted effects into adulthood and even across generations. Dr. Hurd's basic science research is complemented by clinical laboratory investigations evaluating the therapeutic potential of novel science-based strategies for the treatment of opioid addiction and related psychiatric disorders including pioneering work with cannabidiol. Today on the show we discuss: how cannabis changes the brain, why it messes with your ability to manage stress, why cannabis is more dangerous today, what must happen to prevent kids from abusing cannabis, what cannabis does to mental health, whether or not it's a gateway drug, how recover from cannabis addiction and more.  ⚠ WELLNESS DISCLAIMER ⚠ Please be advised; the topics related to health and mental health in my content are for informational, discussion, and entertainment purposes only. The content is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek the advice of your health or mental health professional or other qualified health provider with any questions you may have regarding your current condition. Never disregard professional advice or delay in seeking it because of something you have heard from your favorite creator, on social media, or shared within content you've consumed. If you are in crisis or you think you may have an emergency, call your doctor or 911 immediately. If you do not have a health professional who is able to assist you, use these resources to find help: Emergency Medical Services—911 If the situation is potentially life-threatening, get immediate emergency assistance by calling 911, available 24 hours a day. National Suicide Prevention Lifeline, 1-800-273-TALK (8255) or https://suicidepreventionlifeline.org.  SAMHSA addiction and mental health treatment Referral Helpline, 1-877-SAMHSA7 (1-877-726-4727) and https://www.samhsa.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. John Krystal is McNeil Professor and Chair of Psychiatry at Yale and Yale-New Haven Hospital. He studies the neurobiology and treatment of psychiatric disorders. He directs the Yale Center for Clinical Investigation, Center for the Translational Neuroscience of Alcohol, and Neuroscience Division of the National Center for PTSD. Today on the show we discuss: The biggest risks people are overlooking with cannabis, why cannabis can be harmful for the brain and increase your risk of psychosis or schizophrenia, Dr. Krystal's thoughts on how cannabis impacts mental health and PTSD, why maintaining a healthy lifestyle is so important for your mental health, why cannabis is so addictive, whether or not the brain can heal itself after coming off cannabis and much more. ⚠ WELLNESS DISCLAIMER ⚠ Please be advised; the topics related to health and mental health in my content are for informational, discussion, and entertainment purposes only. The content is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek the advice of your health or mental health professional or other qualified health provider with any questions you may have regarding your current condition. Never disregard professional advice or delay in seeking it because of something you have heard from your favorite creator, on social media, or shared within content you've consumed. If you are in crisis or you think you may have an emergency, call your doctor or 911 immediately. If you do not have a health professional who is able to assist you, use these resources to find help: Emergency Medical Services—911 If the situation is potentially life-threatening, get immediate emergency assistance by calling 911, available 24 hours a day. National Suicide Prevention Lifeline, 1-800-273-TALK (8255) or https://suicidepreventionlifeline.org.  SAMHSA addiction and mental health treatment Referral Helpline, 1-877-SAMHSA7 (1-877-726-4727) and https://www.samhsa.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Kirk Erickson is Director of Translational Neuroscience and Mardian J. Blair Endowed Chair of Neuroscience at the AdventHealth Research Institute, Neuroscience Institute. Dr. Erickson received his Ph.D. at the University of Illinois at Urbana-Champaign and was a post-doctoral scholar at the Beckman Institute for Advanced Science and Engineering. He was also a Professor of Psychology and Neuroscience at the University of Pittsburgh before starting at AdventHealth. Dr. Erickson's vast research program focuses on the effects of physical activity on brain health across the lifespan. This research has resulted in > 250 published articles and 15 book chapters. Dr. Erickson's research has been funded by numerous awards and grants from NIH, the Alzheimer's Association, and other organizations. He has been awarded a large multi-site Phase III clinical trial examining the impact of exercise on cognitive function in cognitively normal older adults. His research resulted in the prestigious Chancellor's Distinguished Research Award from the University of Pittsburgh. He was named a Fellow of the Academy of Behavioral Medicine Research in 2016, and a Distinguished Scientist Award by Murdoch University in 2018. He currently holds a Visiting Professor appointment at the University of Granada, Spain. Dr. Erickson was a member of the 2018 Physical Activity Guidelines Advisory Committee, and chair of the Brain Health subcommittee charged with developing the second edition of the Physical Activity Guidelines for Americans. His research has been featured in a long list of print, radio, and electronic media including the New York Times, CNN, BBC News, NPR, Time, and the Wall Street Journal.   This podcast episode is sponsored by Fibion Inc. | Better Sleep, Sedentary Behaviour and Physical Activity Research with Less Hassle --- Learn more about Fibion Sleep and Circadian Rhythm Solutions: https://sleepmeasurements.fibion.com/ --- Collect, store and manage SB and PA data easily and remotely - Discover ground-breaking Fibion SENS: https://sens.fibion.com/ --- SB and PA measurements, analysis, and feedback made easy.  Learn more about Fibion Research : fibion.com/research --- Fibion Kids - Activity tracking designed for children. https://fibionkids.fibion.com/ --- Collect self-report physical activity data easily and cost-effectively https://mimove.fibion.com/ --- Follow the podcast on Twitter https://twitter.com/PA_Researcher Follow host Dr Olli Tikkanen on Twitter https://twitter.com/ollitikkanen Follow Fibion on Twitter https://twitter.com/fibion https://www.youtube.com/@PA_Researcher

Dr. Kirk Erickson is Director of Translational Neuroscience and Mardian J. Blair Endowed Chair of Neuroscience at the AdventHealth Research Institute, Neuroscience Institute. Dr. Erickson received his Ph.D. at the University of Illinois at Urbana-Champaign and was a post-doctoral scholar at the Beckman Institute for Advanced Science and Engineering. He was also a Professor of Psychology and Neuroscience at the University of Pittsburgh before starting at AdventHealth. Dr. Erickson's vast research program focuses on the effects of physical activity on brain health across the lifespan. This research has resulted in > 250 published articles and 15 book chapters. Dr. Erickson's research has been funded by numerous awards and grants from NIH, the Alzheimer's Association, and other organizations. He has been awarded a large multi-site Phase III clinical trial examining the impact of exercise on cognitive function in cognitively normal older adults. His research resulted in the prestigious Chancellor's Distinguished Research Award from the University of Pittsburgh. He was named a Fellow of the Academy of Behavioral Medicine Research in 2016, and a Distinguished Scientist Award by Murdoch University in 2018. He currently holds a Visiting Professor appointment at the University of Granada, Spain. Dr. Erickson was a member of the 2018 Physical Activity Guidelines Advisory Committee, and chair of the Brain Health subcommittee charged with developing the second edition of the Physical Activity Guidelines for Americans. His research has been featured in a long list of print, radio, and electronic media including the New York Times, CNN, BBC News, NPR, Time, and the Wall Street Journal.   This podcast episode is sponsored by Fibion Inc. | Better Sleep, Sedentary Behaviour and Physical Activity Research with Less Hassle --- Learn more about Fibion Sleep and Circadian Rhythm Solutions: https://sleepmeasurements.fibion.com/ --- Collect, store and manage SB and PA data easily and remotely - Discover ground-breaking Fibion SENS: https://sens.fibion.com/ --- SB and PA measurements, analysis, and feedback made easy.  Learn more about Fibion Research : fibion.com/research --- Fibion Kids - Activity tracking designed for children. https://fibionkids.fibion.com/ --- Collect self-report physical activity data easily and cost-effectively https://mimove.fibion.com/ --- Follow the podcast on Twitter https://twitter.com/PA_Researcher Follow host Dr Olli Tikkanen on Twitter https://twitter.com/ollitikkanen Follow Fibion on Twitter https://twitter.com/fibion https://www.youtube.com/@PA_Researcher

Dr. David G. Amaral (University of California, Davis) is an author of a review paper in the April issue of AJP looking at the use of animal models and other forms of translational neuroscience in the investigation of autism spectrum disorder.  He joins us on AJP Audio to discuss it.  Afterwards, we'll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the April issue.  Transcript   Amaral interview [00:56] Advantages and disadvantages of animal model research [02:14] What goes into determining which animals might be good candidates for research in human neurology? [04:52] How does basic research get translated into clinical treatments? [08:28] Alternatives to animal models [10:21] Promise of research moving forward [12:22] Kalin interview [15:30] Veenstra-VanderWeele et al. [15:46] Kato et al. [17:02] Zwicker et al. [19:17] Kim et al. [22:22] Zeng et al. [26:14] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Episode 43: Interview with Professor Stephen Davis & Geoffrey Donnan of the Australian Stroke Alliance. The Australian Stroke Alliance is comprised of more than 30 organisations working together to transform stroke care across Australia and improve the lives of those affected by stroke. They are developing novel mobile imaging, digital health and emergency transport technologies to radically transform stroke outcomes and deliver commercial benefits for all Australians. Rather than transporting patients to hospital, they drive or fly Australian-designed life-saving brain scanning equipment to a patient during the Golden Hour for Stroke, transforming their chances of survival and recovery. For Australians living in rural, remote and Indigenous communities, access to stroke treatment during the Golden Hour for Stroke is limited or non-existent – creating inequity and a major gap in health outcomes. The Australian Stroke Alliance is about equity, world-first innovation and bringing time-critical stroke treatment direct to the patient. About our guests: PROFESSOR GEOFFREY DONNAN AO Geoffrey is a professor of Neurology at The University of Melbourne and former Director of The Florey Institute of Neuroscience and Mental Health. He is the co-lead of the Australian Stroke Alliance and the Frontiers MRFF grant. His research interest is clinical stroke management. He was co-founder, with Professor Stephen Davis, of the Australian Stroke Trials Network. He is the co-chair of the EXTEND group of trials, including the recently published EXTEND IA trial of thrombectomy in acute ischaemic stroke. He was Editor-in-Chief of the International Journal of Stroke and is Past President of the World Stroke Organization. PROFESSOR STEPHEN DAVIS AO Stephen is a professor of Translational Neuroscience at the University of Melbourne, Director of the Melbourne Brain Centre at the Royal Melbourne Hospital and a Past-President of the World Stroke Organization. He co-chairs the Melbourne Mobile Stroke Unit program. His research is focussed on acute therapy for both ischemic stroke and intracerebral haemorrhage, particularly the use of advanced imaging in selection of therapy. He is the co-lead of the Australian Stroke Alliance and the Frontiers MRFF grant. https://austrokealliance.org.au Show Credits: Music intro credit to Jake Dansereau, connect at JAKEEZo on Soundcloud @user-257386777. Our intro welcome is the voice of Caroline Goggin, a stroke survivor and our first podcast guest! Please listen to her inspiring story on Episode 2 of the podcast. Thank you Caroline! Until next time, be sure to give the show a like and share, +follow and connect with us on social or contact us to support us as a show sponsor or become a guest on the Know Stroke Podcast. Visit our new website to apply here: https://www.knowstrokepod.com/ Connect with Us and Share our Show on Social: Website | Linkedin | Twitter | YouTube

Depression is the #1 most common mental illness… but why does it feel like there's still so much we don't know about it? With a rise in mental health awareness, it's becoming a more common practice to see a therapist or take medications for illnesses like depression - yet the likelihood of ever being “cured” is slim to none. In fact, remission and relapse remain at an all-time high. This goes for more serious cases, but it also explains why the “winter blues” are a recurring thing… (no coincidence this podcast is out in January.

Olivia har spurgt, om Brainstorm vil lave en podcast om, hvordan nerverne ude i kroppen kommunikerer med hjernen, og hendes ønske er vores lov. Vi har dykket ned i forskning i smerte, som er et forskningsfelt, der netop undersøger, hvordan kroppen sender signaler op til hjernen. I denne podcast fortæller smerteforsker Christian Bjerggaard Vægter, hvordan nervesystemet er delt op, hvilken kommunikation der sker mellem krop og hjerne, når vi kommer til skade, og Jais agerer tilmed forsøgskanin i et kendt smerteforsøg, der involverer en hånd og noget frysende koldt vand. Sidst i episoden introducerer Josefine og Jais et nyt element ved navn ‘Fast indslag', der er et fast indslag, der fremover er en fast del af Brainstorm, og som, ja…få forklaringen sidst i episoden. (Advarsel: farhumor kan forekomme). Brainstorm er støttet af Lundbeckfonden. Medvirkende: Christian Bjerggaard Vægter, lektor på Institut for Biomedicin og på Danish Research Institute of Translational Neuroscience på Aarhus Universitet Brainstorm er på Instagram og på TikTok.

Motor Neuron Disease (MND) is a degenerative disease that relentlessly attacks the human nervous system, deteriorating muscle function to the point where patients can no longer move, talk, eat, or even breathe. To date there's no cure, and until fairly recently there were only minimal treatments to ease the symptoms. Pam Shaw has dedicated her career to changing that. A Professor of Neurology at Sheffield University and Founding Director of the Sheffield Institute for Translational Neuroscience, she recently led clinical trials into a drug that delivered unprecedented results: showing that it could slow the progression of MND in certain patients, and even improve symptoms for some. It's just one small step – but with a new tranche of research funding and a national institute to study the disease on the cards, Pamela believes this could be the start of real progress in understanding and treating Motor Neuron Disease. Producer: Lucy Taylor

In this podcast molecular Biologist Dr Elena Seranova joins us to talk through some of the exciting anti-aging and longevity compounds on the market currently, the research behind them and what they do in the body. We consider  what you should think about when deciding to take a supplement what each compound does, it's mechanism of action what aging hallmarks each compounds combats. what senescent cells are and what senolytics do, the importance of methylation  we cover Quercetin, Trimethylglycine, Nicotinamide Mononucleotide and Berberine Tune in to get the latest information on this exciting compounds and where the research is headed next.     About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr. Elena and her work, visit NMN Bio.   Health Optimisation Consulting with Lisa  Are you struggling with a health issue and need someone who looks outside the square and someone  connected to some of the greatest science and health minds in the world? Then reach out to us at lisa@lisatamati.com, we can jump on a call to see if we are a good fit for you or visit  Lisa's Health Consulting If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at lisa@lisatamati.com.   Order Lisa's Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless.   Lisa's Anti-Ageing and Longevity Supplements  Lisa's full range of anti-aging, longevity and health optimisation supplements curated by Lisa herself working with some of the best supplement producers in the world.  https://shop.lisatamati.com/ NMN: Nicotinamide Mononucleotide, an NAD+ precursor   Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time.   What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today.   Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules   Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility   Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos   Ketone-IQ Get your fuel from ketones. Ketones are nature's superfuel, proven to support energy, focus, endurance, and more. Developed alongside the U.S. military and top universities, Ketone-IQ™ delivers all those benefits in one drink. No caffeine, no sugar—just clean, on-demand energy for superior physical and cognitive performance. You can read about it here and  https://shop.lisatamati.com/products/ketone-iq%E2%84%A2?_pos=2&_sid=727714231&_ss=r   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! You can also connect with Matty on his Website YOUR DNA 360 REPORT + ONE-ON-ONE CONSULTATION    Enjoyed This Podcast? If you did, subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can discover the benefits of an infrared sauna. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa    

Addiction is at an all-time high in the United States and the results are deadly. During the COVID-19 pandemic, binge drinking increased by 21 percent and drug overdoses claimed more than 100,000 lives in just a 12-month period.    But what causes a person to develop an addiction? Why are substance use disorders so complicated to treat? And what new treatments are giving people hope that recovery is possible?   MPR News shares “Substance Use & New Paths to Recovery,” a special broadcast from Call to Mind, American Public Media's initiative to foster conversations about mental health. Through in-depth interviews and reported stories, we hear firsthand from individuals who have recovered from substance use disorders, clinicians leading research to transform the treatment field, and experts who work to decriminalize substance use disorders.   Call to Mind specials are hosted by Kimberly Adams, senior correspondent for APM's Marketplace who covers mental health, politics, business and the economy from Washington, D.C. Guests: Scott Edwards is an associate professor of physiology at LSU Health Sciences Center and the associate director at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) a T32 Program.  Yasmin Hurd is the director of the Addiction Institute within the Mount Sinai Behavioral Health System and the Ward Coleman Chair of Translational Neuroscience. She is also a professor of psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai.  Carrie Kappel is a registered nurse and the board co-chair of the Minnesota Nursing Peer Support Network (NPSN), manager of operations of addiction services at Allina Health.  Dr. Joji Susuki is the director of the Division of Addiction Psychiatry at Brigham and Women's Hospital and an assistant professor at Harvard Medical School.   Subscribe to the MPR News with Angela Davis podcast on: Apple Podcasts, Google Podcasts, Spotify or RSS.  Use the audio player above to listen to the full conversation.   

                                Dr Samantha Boardman and Dr Dilip Jeste discuss the techniques you can use to become wiser. Hosted by Duff Watkins About Dr Dilip Jeste Dilip Jeste is a neuropsychiatrist and professor at the University of California, San Diego.  He is author of Wiser: the scientific roots of wisdom (and 13 other books).  His 625 published scientific papers are among most cited in the world (he's in the top .5% of publishing researchers).  He was the first Asian-American elected President of the American Psychiatric Association in its 175 year history which has over 40,000 members.  He is listed in “Best Doctors in America.” About Dr Samantha Boardman a New York based positive psychiatrist, who is committed to fixing what's wrong and building what's strong. Positive Psychiatry takes a more expansive approach, focusing on the promotion of wellbeing and the creation of health. private practice in Manhattan. published papers in journals including Translational Neuroscience, Nature Reviews Neuroscience, The American Journal of Psychiatry, and The Journal of Clinical Psychiatry. I'm also a frequent contributor to Psychology Today, The Wall Street Journal, and Thrive Global, and a guest on the Today Show and Good Day New York. Author of Everyday Vitality: turning Stress into Strength. Founder of PositivePrescription.com Episode Notes Lesson 1: What would X do?  02:46 Lesson 2: You won't be wise until you regulate your emotions 09:48 Lesson 3: Move towards, not away; be pro-social not anti-social 16:53 Lesson 4: Practice compassion (start with yourself) 23:10 Lesson 5: Affirm a Value Today 32:16 Lesson 6: Think Best, Worst, Most Likely (accept uncertainty) 39:39 Lesson 7: Re-frame the meaning of so called 'bad' events 44:12 Lesson 8: Build the Habit of “Good Enough” 50:41 Lesson 9: Be Your Own Emotional Detective:  channel your inner Sherlock Holmes   Lesson 10: Look Up!  Find your spirituality 58:20

Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever | Brought to you by Athletic Greens all-in-one nutritional supplement, Helix Sleep premium mattresses, and Allform premium, modular furniture. Dr. John Krystal is the Robert L. McNeil, Jr., Professor of Translational Research; Professor of Psychiatry, Neuroscience, and Psychology; Chair of the Department of Psychiatry at Yale University; and Chief of Psychiatry and Behavioral Health at Yale-New Haven Hospital.Dr. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.He directs/co-directs the Yale Center for Clinical Investigation (CTSA), NIAAA Center for the Translational Neuroscience of Alcoholism, and Clinical Neuroscience Division of the National Center for PTSD (VA).Dr. Krystal is a member of the U.S. National Academy of Medicine; co-director of the Neuroscience Forum of the U.S. National Academies of Sciences, Engineering, and Medicine; Fellow of the American Association for the Advancement of Science (AAAS); and editor of Biological Psychiatry, one of the most selective and highly cited journals in the field of psychiatric neuroscience.He is the co-founder and Chief Scientific Advisor of Freedom Biosciences, a clinical-stage biotechnology platform developing next-generation ketamine and psychedelic therapeutics that recently emerged from stealth in August 2022.ONE VERY IMPORTANT DISCLAIMER: I'm not a doctor, nor do I play one on the Internet. None of the content in this podcast constitutes medical advice or should be construed as a recommendation to use ketamine or psychedelics. There are psychological, physical, and sometimes legal risks with such usage. Please consult your doctor before considering anything we discuss in this episode.Please enjoy!*This episode is brought to you by Helix Sleep! Helix was selected as the #1 overall mattress of 2020 by GQ magazine, Wired, Apartment Therapy, and many others. With Helix, there's a specific mattress to meet each and every body's unique comfort needs. Just take their quiz—only two minutes to complete—that matches your body type and sleep preferences to the perfect mattress for you. They have a 10-year warranty, and you get to try it out for a hundred nights, risk-free. They'll even pick it up from you if you don't love it. And now, Helix is offering up to 200 dollars off all mattress orders plus two free pillows at HelixSleep.com/Tim.*This episode is also brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That's up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by Allform! If you've been listening to the podcast for a while, you've probably heard me talk about Helix Sleep mattresses, which I've been using since 2017. They also launched a company called Allform that makes premium, customizable sofas and chairs shipped right to your door—at a fraction of the cost of traditional stores. You can pick your fabric (and they're all spill, stain, and scratch resistant), the sofa color, the color of the legs, and the sofa size and shape to make sure it's perfect for you and your home.Allform arrives in just 3–7 days, and you can assemble it yourself in a few minutes—no tools needed. To find your perfect sofa and receive 20% off all orders, check out Allform.com/Tim.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My guest today, Dr. Eliott Berkman, is a tenured Associate Professor of Psychology at the University of Oregon, where he directs the Social and Effective Neuroscience Laboratory and conducts field-leading, federally-funded research on goals, motivation, and behavior change. He's also the Associate Director of the Center for Translational Neuroscience, and an author who writes about psychology and neuroscience for lay audiences, including in Psychology Today. We talk about the concept of the will and the way of goal pursuing, where the way is the set of cognitive skills, capacities, and ability that we collectively call the executive function, and the will is the motivational factors that propel the behavior. We also talk about how to increase our motivation and influence other people's behavior, the idea of flow states, and how that applies to achieving goals.

The Dementia Researcher, ISTAART Relay Podcast is back for a third, 5-part series. Where the interviewee becomes the interviewer. With five leading researchers discussing their research, their field, and the work of the Alzheimer's Association ISTAART Professional Interest Area they represent. Part Two – Dr Rik Ossenkoppele, interviews Dr Hamid Sohrabi representing the Resilience and Protective Factors PIA Dr Rik Ossenkoppele is an Associate Professor of Translational Neuroscience at Amsterdam UMC and Lund University. His area of research is Alzheimer's disease and other neurodegenerative disorders, brain imaging, biomarkers, cognition. Rik also happens to be a qualifiied PE Teacher, and he is representing the ISTAART Atypical Alzheimer's Disease PIA. Dr Hamid Sohrabi is Director of the Centre for Healthy Ageing - Associate Professor of Psychology and Clinical Neurosciences at Murdoch University, Australia. His research is focussed on screening and clinical diagnostic measures as well as identifying dementia risk factors and resilience and resisting factors including cognitive reserve. Outside work he loves DIY (but never ask him to fit a gate in your garden). Hamid is representing the ISTAART Reserve, Resilience and Protective Factors PIA. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) convenes the global Alzheimer's and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer's and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 29 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART (free for students worldwide, and for people of all grades in Low and Middle Income Countries) and a PIA visit: http://www.alz.org/istaart To book your place at this years AAIC Confernence visit: https://aaic.alz.org/ Visit our YouTube Channel to watch the video version of this podcast: https://youtu.be/iWBLNot4M6E Find more information on our guests, and a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/istaart-relay-podcast-immunity-and-neurodegeneration-pia/ -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

The Dementia Researcher, ISTAART Relay Podcast is back for a third, 5-part series. Where the interviewee becomes the interviewer. With five leading researchers discussing their research, their field, and the work of the Alzheimer's Association ISTAART Professional Interest Area they represent. Part One – Professor Charlotte Teunissen, interviews Dr Rik Ossenkoppele representing the Atypical Alzheimer's Disease PIA Charlotte Teunissen is a Professor in Neurochemistry at Amsterdam UMC. Charlotte explores Biomarkers in body fluids, such as cerebrospinal fluid and blood, to understand the disease and improve care for neurological diseases, especially dementias and Multiple Sclerosis. She is representing the ISTAART Biofluid Based Biomarkers PIA. Dr Rik Ossenkoppele is an Associate Professor of Translational Neuroscience at Amsterdam UMC and Lund University. His area of research is Alzheimer's disease and other neurodegenerative disorders, brain imaging, biomarkers, cognition. Rik also happens to be a qualifiied PE Teacher, and he is representing the ISTAART Atypical Alzheimer's Disease PIA. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) convenes the global Alzheimer's and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer's and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 29 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART (free for students worldwide, and for people of all grades in Low and Middle Income Countries) and a PIA visit: http://www.alz.org/istaart To book your place at this years AAIC Confernence visit: https://aaic.alz.org/ Visit our YouTube Channel to watch the video version of this podcast: https://youtu.be/3CO3_W_0qtw Find more information on our guests, and a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/istaart-relay-podcast-immunity-and-neurodegeneration-pia/ -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

"We have those two groups with the probiotics and the placebo. The patients were allocated to the two groups and it was double-blind so we didn't know if they took the probiotics or the placebo. They took it for four weeks and we did the assessments before the intervention and after the intervention and then we just compared. We compared how the trajectory of the depressive symptoms was in the two groups and this is the main effect that we found - that in the probiotics group the decrease of the depressive symptoms was greater than in the placebo group. In general, we were happy that all patients have decreased depressive symptoms, that is very important too, but the effect that we want to show is that the probiotics are better than the normal treatment."     Episode Description: We begin by describing the research findings which are that this is the first randomized controlled trial to demonstrate that adjunctive short-term, high-dose probiotic supplementation reduces depressive symptoms more than placebo. We discuss the conflicting results of the two rating scales that were used to measure improvements and their implications for the outcomes. Anna-Chiara reports on the probiotic that was chosen and whether it led to the researchers themselves taking it. She emphasized the importance of one's diet and especially the role of fermented foods. We closed with her describing her earlier research that suggested that Fecal Microbiota Transplantation can be an effective form of treatment for severely depressed patients.    Our Guest: Anna-Chiara Schaub is a psychologist and Ph.D. student in the research group Translational Neuroscience at the University Psychiatric Clinics in Basel, Switzerland. In her project, she explores wide-ranging clinical and physiological effects of gut-related interventions in depression. Her research aims to stratify patients into more homogenous groups based on individual differences in multiple biomarkers to predict treatment responses. The findings of the project may also serve as the basis for further developments of novel interventions for patients with depression. 

Dyskinesia is a condition involving erratic, uncontrollable muscle movements such as twitches, jerks, twisting, or writhing of the face, arms, legs, or trunk. It can be a complication after long-term use of levodopa to treat Parkinson's disease. Dyskinesias can be mild, or they may be severe enough to interfere with normal functioning.   Basic laboratory research has revealed some of the changes in the brain after long-term exposure to levodopa. In this episode, Kathy Steece-Collier, PhD, a professor in the Department of Translational Neuroscience in the Michigan State University College of Human Medicine in Grand Rapids, discusses her research into the biologic mechanisms of levodopa-induced dyskinesias and a possible future prevention and treatment for them.   Funded by an International Research Grant from the Parkinson's Foundation, she delineated the role of calcium channels, which allow calcium to enter nerve cells in the brain, in the development of levodopa-induced dyskinesias. Based on those findings, she is now working on an approach that uses a single injection into a part of the brain that is affected in Parkinson's disease (the striatum) that may have the potential for long-term prevention or relief of dyskinesias. The idea is to introduce a short piece of RNA with a tight hairpin turn in it, called a short hairpin RNA (shRNA), to silence the gene that leads to abnormal calcium channel signaling in the striatum that causes dyskinesia. Dr. Steece-Collier also explains how this technique may have advantages over drug therapy to control dyskinesia.

It's typical for athletic performance to decline with age. (And, athletes may experience signs of accelerated aging caused by intense training.) If you're worried about your declining performance, start looking at how you train and what you eat. We may not be able to reverse our chronological age, but we can guide our bodies through the ageing process.  Did you know that there are longevity strategies specifically for athletes? These strategies consider long-term performance, health, and muscle growth!  In this episode, Dr. Elena Seranova joins us to discuss how ageing can affect our bodies and our athletic performance. She shares her strategies, from supplements to lifestyle changes, that can help athletes combat the effects of ageing. If you're overwhelmed by all of the information out there, remember: you need to build a good foundation first. Start with eating right and sleeping well; from there, you can eventually incorporate Dr. Elena's other recommendations. If you want to learn longevity strategies for athletes and how to improve athletic performance, then this episode is for you! Here are three reasons why you should listen to the full episode: Discover how ageing affects athletic performance and why athletes may experience signs of accelerated ageing.  Learn longevity strategies that will support athletic performance and your general health, like how to activate your autophagy pathways. Understand that longevity is a process of building good habits; you can start out by focusing on the basics, like diet and sleep.  Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, which is all about optimising your fitness, lifestyle, nutrition and mental performance for your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, and Run Longer  Without Burnout or Injuries Have you struggled to fit training into your busy life? Maybe you don't know where to start, or you have done a few races but struggle with motivation or injuries? Do you want to beat last year's time, or finish at the front of the pack? Do you want to run your first 5-km, or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. NMN Bio offers pure supplements that are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party-tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of ageing, and is designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility. Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health Episode Highlights [02:32] Why Athletic Performance Drops as We Age The main cause of athletic performance decline is mitochondrial decline. Mitochondrial decline is linked to senescence cells.  Senescence cells stop dividing and do nothing. As we age, we may have 5-20% senescence cells in different tissues.  This causes inflammation and causes the mitochondria to function improperly, thus increasing reactive oxygen species within cells.  Nuclear DNA is usually packed in histones, which preserve genetic material. However, mitochondrial DNAs lack histones, making it prone to oxidative stress and mutations.    As we age, our epigenetic processes become less efficient; it becomes a vicious cycle with more reactive oxygen species and less capacity to deal with them.  [08:23] How Else Do Our Bodies Respond to Ageing Ageing declines autophagy, which recycles cellular organelles.  When there's nothing to clean up dysfunctional mitochondria, problems with energy generation arise. Athletes who have exercised intensely their whole life will have worn-off tissues and lactic acid buildup.  Remember, exercise is good, since we want some level of oxidative stress; however, we don't want more oxidative stress than what our body can cope with.  Lisa shares how running ultramarathons accelerated her ageing process, wear and tear, and inflammation.  [12:29] How to Support Autophagy and Athletic Performance?  Intermittent fasting is when people have a certain feeding window a day. After eating, mTOR switches off and AMPK is activated which allows for autophagy.   If you want to build muscle, Dr. Elena recommends eating after exercising so you can activate mTOR which helps with muscle growth.    You need to create a cycle going of mTOR and AMPK since autophagy recycles cells back into amino acids, which can help cells build new proteins.  Don't create a feeding window that's too narrow; you need to have enough fuel for your body. Eat chicken, meat, and foods rich in amino acids.  Make sure you're sleeping properly, as this can affect your muscle growth.  [18:30] Supplements to Support Autophagy and Longevity You can also support autophagy through supplements like berberine.  Dr. Elena recommends adding supplements to specifically target senescence cells. Senolytics help kill senescence cells while senomorphics modify the senescence cells.  Quercetin added with Vitamin C can help kill senescence cells. By itself, quercetin can produce toxic metabolites, so it needs Vitamin C to serve as an antioxidant.  She also recommends taking their quercetin product with NAC and acetylcysteine to boost glutathione, a potent antioxidant.  Quercetin has many benefits including anti-inflammatory properties, and can be used to combat cardiovascular disease, fight seasonal allergies, and can fight cancer.     [26:51] How to Take Quercetin Quercetin can be found naturally in fruits and vegetables like strawberries and onions.  If you've never taken compounds for their senescent action before, start by taking quercetin at 500 mg every day. After a month of taking it, check in on how you feel.  You can also implement detox protocols with a higher dosage of quercetin(around 2 - 2 ½ grams). If you want to implement this protocol, start with 5 days first.  Quercetin can be combined with 500mg of chlorella to boost the detoxifying reaction. People with kidney diseases should consult with a doctor before taking quercetin.   [32:43] How NMN Can Help Athletes  In addition to mitochondrial decline, athletes can experience loss of endurance and muscle loss as they age.  Dr. Elena recommends increasing your fasting window depending on your goals.  You want more oxygenation in your tissues to preserve endurance and muscle.  Dr. Elena offers an NMN product that can increase both endurance and prevent age-related muscle loss.    This can help increase insulin sensitivity, activating longevity genes and DNA repair.  [36:37] How to Optimise NMN  NMN functions optimally when it's attached to a methyl group. Unfortunately, our body's methylation process also declines with age.  NMN should be paired with TMG, as it is a rich methyl donor.  When you combine NMN, TMG, and quercetin, you'll optimise your performance and endurance. [39:11] Longevity is Your Biological Age, Not Your Chronological Age Many people over 40 are insulin resistant. Insulin resistance is a gateway to biological decline.  You can check your insulin resistance by checking your waist to hip ratio.  After the age of 40, it's much easier to experience hormonal dysfunction.  We need to make a conscious effort to improve our health. Ageing can cause issues to spiral if left uncontrolled.   [42:50] Be Careful With Your Food 80% of adults in the west are insulin resistant.  The food industry worsens the condition by offering so many processed carbohydrates.  Many people have false ideas about what a healthy diet is. You can't have too many carbohydrates and sugar, even if they're coming from fruits.  Cut down on carbohydrates, avoid processed foods, and take good oils.  [45:21] Start with the Basics Start with the basics. You don't need to add supplements immediately.  Just eat clean and good food. There's no such thing as a universal diet.  Taking cold showers in the morning can improve hormonal balance. You can start with just 10 seconds of cold exposure.  Manage your stress levels and make sure you move regularly.  You don't need to be perfect.  [50:47] How Some People Live to 100  There were two hypotheses surrounding centenarians: good habits and the absence of high-risk genes. However, some centenarians were found to have bad habits and mutations for Alzheimer's disease.  Centenarians have genes that mitigate risks from bad mutations. They also have low IGF 1 levels.  When people are young, IGF 1 can improve muscle and tissue growth, but it can be harmful when people grow older. Centenarians' genetic combination allowed for IGF to decrease as they grow older. Listen to the episode to learn more about how centenarians' hormonal processes are being regulated. Commit to regularly regulating and balancing your hormones. This process starts with clean food, caloric restriction, and exercise.     About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr. Elena and her work, visit NMN Bio. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Want to learn more from Dr Dom? Check out our previous episode with her:  Episode 238 - Reverse Ageing to Live Longer and Healthier with Dr. Elena Seranova Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova        Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer  Deep Nutrition: Why Your Genes Need Traditional Food by Catherine Shanahan, M.D.  Centenarians, metformin, and longevity | Nir Barzilai, M.D., Episode 204 from the Peter Attia podcast  Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health Visit NMN Bio to know more about NMN supplements!  

The process of addiction involves completely abandoning expectations. They no longer serve you, nor anyone else involved in the process. But...those hopes do exist. In this Episode I site Nora McInerny journey of grieving her Husband's death and how Nora refused to let anyone 'Should' all over her in how to heal from this loss. The same can happen with parents of children battling addiction. But who are we serving when we hold on to expected milestones of pre-defined success? For me, no one.1:30 - Nora McInerny, Don't Should all over Yourself, at about 4:19 in.4:05 - Nora McInerny, We don't "move on" from grief. We move forward with it, TedHealth 5:30 - On Mourning and Recovery: Integrating Stages of Grief and Change Toward a Neuroscience-based Model of Attachment Adaptation in Addiction Treatment. Note, in the Podcast I stated both are from the Indiana University School of Medicine, which does not apply to Sue C. Wallingford, who is the Chair, Division of Transpersonal Counseling and Psychology, Associate Professor, Graduate School of Counseling & Psychology, Naropa University, Boulder, CO.  R. Andrew Chambers, MD1, is the Director, Addiction Psychiatry Training Program & Lab for Translational Neuroscience of Dual Diagnosis, Associate Professor, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.6:35 - Nucleus Accumbens7:35 -The Diagnostic and Statistical Manual of Mental Disorders (DSM) definition from Psychology Today8:30 - Connection and Addiction explained in a TedTalk, Everything you think you know about addiction is wrong, by Johann HariThank you for listening and please visit www.siblinghoodofrecovery.com for free resources, links to organizations, groups and individuals who can offer help in the Journey of Recovery towards healing from substance use disorders. If you like this Podcast, please leave a rating on wherever you're listening. It will help to get the word out. If there is one message I can leave you with, the best you can offer your loved one battling addiction is love and a healthier you. Walk gently, my friend.

Migraines are PAINFUL! And neuroscience speaking - super cool and complicated.  It involves your blood vessels constricting and dilating and your brain going haywire and spreading a wave of neuron depression across your entire cortex. Sound interesting? Come and take a listen to learn a little bit more about what happens in your brain!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Citations and relevant pictures are below:Headache disorders. www.who.int. https://www.who.int/news-room/fact-sheets/detail/headache-disorders#:~:text=Half%20to%20three%20quarters%20ofMigraine Headaches: Symptoms, Causes, Treatment & Prevention. Cleveland Clinic. Published March 3, 2021. https://my.clevelandclinic.org/health/diseases/5005-migraine-headachesRuthirago D, Julayanont P, Kim J. Translational Correlation. Conn's Translational Neuroscience. Published online 2017:159-165. doi:10.1016/b978-0-12-802381-5.00013-0Mason BN, Russo AF. Vascular Contributions to Migraine: Time to Revisit? Frontiers in Cellular Neuroscience. 2018;12. doi:10.3389/fncel.2018.00233Wikipedia Contributors. Aristides Leão. Wikipedia. Published January 9, 2022. Accessed March 22, 2022. https://en.wikipedia.org/wiki/Aristides_Le%C3%A3oLauritzen M. Pathophysiology of the migraine aura. Brain. 1994;117(1):199-210. doi:10.1093/brain/117.1.199Schain AJ, Melo-Carrillo A, Stratton J, Strassman AM, Burstein R. CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura. The Journal of Neuroscience. 2019;39(30):6001-6011. doi:10.1523/jneurosci.0232-19.2019Charles A, Brennan K. Cortical Spreading Depression—New Insights and Persistent Questions. Cephalalgia. 2009;29(10):1115-1124. doi:10.1111/j.1468-2982.2009.01983.xPietrobon D, Striessnig J. Neurobiology of migraine. Nature Reviews Neuroscience. 2003;4(5):386-398. doi:10.1038/nrn1102Eisenstein M. Closing the gender gap in migraine research. Nature. 2020;586(7829):S16-S17. doi:10.1038/d41586-020-02867-4Sutherland HG, Albury CL, Griffiths LR. Advances in genetics of migraine. The Journal of Headache and Pain. 2019;20(1). doi:10.1186/s10194-019-1017-9Support the show (https://www.patreon.com/neuroscienceamateurhour)

No one is exempt from ageing, and with aging comes diseases and sickness. Decreased performance and cell production also occur because of this phenomenon. Lifestyle changes may be inadequate to help your body function properly. Over the past years, longevity science has been evolving, with the emergence of several anti-ageing supplements in the market. However, the body may not absorb these supplements effectively enough to slow down the effects of ageing. In this episode, Dr Elena Seranova explains how the ageing process works. She details how to use supplements, complemented by lifestyle changes, to reverse ageing. She also shares how NMN can be coupled with TMG to create the ultimate longevity supplement. There's no one supplement to optimise your health, but good habits and lifestyle changes are integral to having a longer and healthier life! If you want to learn how to reverse ageing through supplements and lifestyle changes, then this episode is for you! Here are three reasons why you should listen to the full episode: Understand the aging process, its vicious cycle, and how it affects and changes our bodies.  Learn how you can slow down and reverse the effects of aging. Discover how you can combine TMG with NMN for better results. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [01:53] How Longevity Science Is Growing There are a growing number of anti-ageing products as we understand the ageing process better. Multiple cellular processes decline or become imbalanced as people age. There are 9 hallmarks of ageing, and the study recently added another hallmark to include inflammation.  The top four killer diseases are cancer, cardiovascular disease, neurodegeneration, and diabetes. The older you are, the higher your chance of developing one of these diseases.  Our body peaks at 25 and starts the aging process from there. [06:06] Why Is NMN Important?  NMN stands for nicotinamide mononucleotide and is a Vitamin B3 derivative.  It's a natural molecule that you can get from food, but getting an efficient dosage requires supplementation. NMN is a precursor to help our metabolism, and it boosts NAD levels. NAD serves as fuel for SIRTUIN proteins that are involved in rejuvenation processes.  NAD is vital to keep our cells healthy and ensure they don't lose their identity. [09:23] What Happens in the Body as We Age Cell identity is vital. What differentiates cells is how certain parts of the genomes are read. As we age, this process can become chaotic.  Chromatin is a substance in a chromosome. Lightly packed chromatin under active transcription is called euchromatin. Heterochromatin, on the other hand, is more condensed and transcriptionally silent. Epigenetic changes can dictate which areas will be active or inactive. This defines how a cell can be expressed. Sirtuins are crucial in making sure the right genes are active and mediating DNA repair. However, they become less efficient as we age.  This is how our epigenetic regulation becomes loose, leading to genomic instability and loss of cellular identity.  [15:33] How Aging Can Create a Vicious Cycle NAD is the fuel source of sirtuin genes. When these genes are depleted, our DNA can't be repaired. As we age, NAD production depletes. DNA breaks and genome instability also increase.  This becomes a vicious cycle of needing more energy but with less production.  Furthermore, genome instability can increase senescence or zombie cells. These can further increase genome instability.  Senescent cells are cells that forget how to do their function well and stop replicating. These cells can further drain NAD levels. [18:19] The Link Between Fasting and Cell Autophagy Autophagy is the process where cells can get rid of toxins and other things that are not needed anymore. Autophagy ensures housekeeping and can be triggered by fasting.  12 hours of fasting can start autophagy in the liver, while 20 hours of fasting can start the process in other tissues.    Eating can activate mTOR, which is another vital cell regulator. This process is deactivated through supplements like Berberine. Learn to balance both eating and fasting. Hear about Dr Elena's fasting schedule and supplements in the full episode! [27:48] Why Dr Elena Launched TMG Methylation is vital for the body's most critical functions. These include creating neurotransmitters, cell division, energy production, metabolism, and epigenetics.  Dr Elena launched TMG to boost NMN's effectiveness and metabolism.  Methylation and TMG can control homocysteine levels, which correlate with cardiovascular diseases. TMG may also enhance athletic performance. It also has a good safety profile with no side effects despite higher dosage. Dr Elena recommends a 1:2 or 1:3 ratio of NMN to TMG. For every 500 milligrams of NMN, take 1 to 2 grams of TMG. [33:31] Do We Need to Worry about Hyper-methylation?  It's difficult to hyper-methylate. However, individual genetic factors can affect homocysteine levels.  To check your homocysteine levels, you can undergo a blood test or check your gene variants with a genetic test TMG is an osmoregulator that helps regulate cell balance and can optimize methylation. After taking over 20 grams, a laxative effect may appear. [39:41] Where to Start Dr Elena recommends taking NMN, TMG, and extra virgin olive oil for anti-ageing. NMN can also help increase insulin sensitivity and boost collagen production, as seen in human clinical trial in prediabetic women. The market has a lot of collagen supplements, but not all of them are absorbed by the body effectively. Insulin sensitivity decreases as we age. This is the body's ability to let glucose flow freely into cells. You can reverse ageing problems with a better lifestyle and supplements. Dr Elena recommends avoiding carbohydrates in your diet. [42:55] How to Have a Healthier Diet Around 80% of adults in the West may be pre-diabetic. So many foods nowadays are made to be addictive.  While a vegan diet can help you detox at first, you will eventually experience amino acid depletion. Dr Elena prefers a carnivore diet. She also does fasting with a three-hour eating window. You can start with a longer eating window and slowly reduce it.  You don't want a glucose spike in the morning. [48:06] You Don't Need to Be Perfect  You don't have to be perfect every day, but make sure you stay consistent with your overall longevity routine.  Exercise and saunas activate Sirtuins. Try to have a routine for one or both. Optimize your routine and find out what works for you.  [50:52] NMN Bio's Growth Dr Elena shares that her company has been growing rapidly. They now have a UK warehouse, UK Amazon FBA, and another warehouse in Europe.  They are also expanding to the United States.  Remember that no one supplement will do everything for you. You also need to change your lifestyle, which includes diet, exercise, and even biorhythms.   There's a lot of information about longevity online, and it can become overwhelming. This is why Dr Elena created an online course about longevity.  Dr Elena recommends making sure your circadian rhythm is not disrupted.  Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Tune in to more Pushing the Limits episodes on health and ageing! Episode 231: The Immune System and How It Fights Cancer Cells and Viruses with Dr Elizabeth Yurth  Episode 196: Rethinking the Function of Mitochondria for Our Health with Dr Elizabeth Yurth  Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  Episode 187: Back to Basics: Slow Down Ageing and Promote Longevity with Dr Elizabeth Yurth Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova  Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer  The Ultimate Anti-Aging Combination: TMG & NMN to Live Significantly Longer? By NMN Bio  The Hallmarks of Aging  Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women Visit NMN Bio to know more about NMN supplements!      Lifespan by Dr David Sinclair    7 Powerful Quotes [04:28] ‘The older you are, the highest your risk of getting one of these diseases; so if it's not gonna be one of them, it's gonna be the other one… Now we start realising when does aging start, which is actually at quite a young age, basically at the age of 25. Because this is where our hormones peak…' [12:25] ‘There are multiple functions that Sirtuins need to attend to within the cell. With age, this function becomes less and less efficient, basically, because sirtuins become more forgetful.' [16:02] ‘So as we age, the production of NAD is declining. So this means that there is less NAD available for sirtuins to use as their fuel to do their job.' [39:52] ‘There are so many collagen supplements on the market, but not all of them are efficient. And actually not all of them are being absorbed properly because when you do take collagen orally, basically, it's broken down into amino acids in your digestive system. And then those amino acids may or may not be used to produce more collagen.' [47:56] ‘We're all on this road of re-educating ourselves and don't go for perfection. Just go for better, I think is a message as well, you don't have to be perfect.' [52:22] ‘With regards to the longevity field, I think that it's very important for people to understand that there is no such thing as the fountain of youth. There is no one supplement that you're going to take that is going to do everything for you.' [56:40] ‘If your melatonin is disrupted, then you will have less defense against reactive oxygen species and that there is another plethora of processes that melatonin is also implicated in and then you don't have all these benefits. And then you're basically aging faster… Takeaway message from today's podcasts. Make sure that you go to sleep early, everyone.' About Dr Elena  Dr Elena Seranova is a scientist, serial entrepreneur and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr Elena then started a private practice before developing an interest in neuroscience. She continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr Elena's expertise in these fields has led her to become the co-founder of a biotech start-up, SkyLab Bio. She has written several peer-reviewed articles on autophagy throughout her career. In addition to these accomplishments, she started her latest business, NMN Bio. Her own experiences with the use of supplements have inspired her to expand the market to supply the public with cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr Elena and her work, visit NMN Bio. Enjoy The Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

You leave many things behind when you head off to retirement. But some surprising things tag along, including stress. And there will be new stressors to deal with in your new life. Psychiatrist Dr. Samantha Boardman, author of Everyday Vitality: Turning Stress into Strength, shares her insights from scientific research in positive psychology and her clinical experience, on how you can bolster your vitality and enhance your well-being. We discuss: Why she went went back to school to become a positive psychiatrist How she defines Vitality How two types of people – Teflon and Velcro -  react to stress Emodiversity Why old dogs can indeed learn new tricks How you can create Uplifts in your day The stories we tell ourselves - and the power of a new narrative The benefits of expanding your horizons How discomfort gives us valuable data Why you should want some “desirable difficulty” in your life Steps to have more Everyday Vitality Dr. Boardman joins us from New York. _________________________ Bio Dr. Samantha Boardman is Clinical Instructor in Psychiatry and Attending Psychiatrist at Weill Cornell Medical College. She is also the founder of PositivePrescription.com, a website that combines her training from medical school and psychiatry with her work and training in the field of positive psychology. Her weekly newsletter, the popular Weekly Dose, shares actionable, productive and digestible advice with her devoted readers.  Samantha received her B.A. from Harvard University, an M.A. in Applied Positive Psychology from the University of Pennsylvania, and a Medical Degree from Cornell University Medical College where she was awarded the Oskar Diethelm Prize for Excellence in Psychiatry. Dr. Boardman has published papers in journals including Translational Neuroscience, The American Journal of Psychiatry and The Journal of Clinical Psychiatry. ___________________________ For More on Dr. Samantha Boardman Everyday Vitality: Turning Stress into Strength  Website Newsletter: The Weekly Dose ____________________________ Podcast Episodes You May Like The Mind-Body Connection and The Rabbit Effect – Kelli Harding Chatter & Your Inner Voice – Ethan Kross Retire Happy – Dr. Catherine Sanderson How to Live a Values Based Life – Harry Kraemer ____________________________ Wise Quotes On Becoming "We get so stuck in this idea of who we are and the story we tell about ourselves. I am a morning person. I don't watch football. I can't stand this. And often, it's really preferences people have or habits about who they are. I think it's Dan Ariely, who spoke about how we're all sort of in the process of becoming. We can all look back and see how much we've changed, but we have such a hard time imagining how much we will change moving forward. And we're all in the process of becoming - no matter what age we are." On Noticing "Her advice was always look for three things every day that are different about your partner. Notice how different they look in that shirt. Notice the way that they are maybe doing something different. Notice when they tell you something. Maybe it's something they've never told you before. Prime yourself to be noticing nuance. This is the essence of mindfulness. It's not meditating. It's just noticing what's different - and what's new. For instance, if you ask people who are playing in an orchestra and they play the same thing every night, play it just a little bit differently. Not that anyone else would notice, but just for you so that there's more nuance in it." On Values, Actions, and Being Intentional "Robert Brooks, who we had spoken about is such an interesting man. And I remember he's talked a lot about how when your values are reflected in your actions and how important that is. And one of the questions I ask my patients when I first meet them is: What are your top three values? And then I'll ask them: So,

Dr. Samantha Boardman is a New York-based positive psychiatrist who is committed to fixing what's wrong and building what's strong. She's also the founder of positiveprescription.com, a website where she shares practical and achievable strategies that are life-enhancing and resilience-building. Samantha is the author of Everyday Vitality, a book that she hopes will inspire readers to find strength within their stress and learn how to live life to the fullest. Samantha and Brit talk about post-pandemic resiliency, the power of connecting with others, and finding genuine fulfillment in life.    IN THIS EPISODE, WE TALK ABOUT: Science-backed positive psychiatry methods  Creating “bad day” backup plans Practicing autonomous support in relationships How to be deliberate about delight in your everyday life Samantha's journey to becoming a ‘positive psychiatrist' and tips for folks who want to enter the field   RESOURCES Text GIRLFRIENDS to 310-496-8363 for updates and a chance to be featured on the show!   CONNECT WITH DR. SAMANTHA BOARDMAN Instagram: @drsamanthaboardman Buy Dr. Boardman's book, Everyday Vitality: penguinrandomhouse.com   CONNECT WITH BRIT Instagram: @britdrisc Squeeze: @squeeze    CONNECT WITH LORI Instagram: @loriharder Lite Pink: @drinklitepink Earn Your Happy: @earnyourhappy Listen to Earn Your Happy   CONNECT WITH ALLI Instagram: @alliwebb  Becket & Quill: @becketandquill  Squeeze: @squeeze   GUEST BIO Dr. Samantha Boardman is a Positive Psychiatrist with a private practice in Manhattan. She is a Clinical Instructor in Psychiatry and Assistant Attending Psychiatrist at Weill Cornell Medical College. She received her B.A. from Harvard University and a Medical Degree from Cornell University Medical College, where she was awarded the Oskar Diethelm Prize for Excellence in Psychiatry. Dr. Boardman has been published in respected industry journals including Translational Neuroscience, The American Journal of Psychiatry and The Journal of Clinical Psychiatry.   After a patient told psychiatrist Samantha Boardman that every session only made her feel worse, Samantha realized, “She was right. I knew how to dial down her misery, but I knew nothing about how to build up her strengths and cultivate wellbeing.” In response to this, Samantha went back to school and received her Masters in Applied Positive Psychology from the University of Pennsylvania and has been practicing Positive Psychiatry ever since.   Dr. Boardman created a website and e-newsletter, Positive Prescription, sharing insights from the psychiatry and psychology community with readers, and exploring the way psychology, culture and science intersect. Through Boardman's website, she shares scientifically backed observations that are life-enhancing and resilience-building. She also profiles influencers spanning all industries from fashion to technology in an online series called “Sessions.” Notable interviewees include Tory Burch, Randi Zuckerberg and Derek Blasberg.   Dr. Boardman is a regular contributor to Psychology Today and has been featured in VOGUE, Refinery29, Harper's Bazaar, The Wall Street Journal, The Coveteur, and Forbes and on the Today Show.

Welcome to the Siim Land podcast I'm your host Siim Land and our guest today is Dr. Elena Seranova. Elena has a Ph.D. in Stem Cell Biology and Autophagy from the University of Birmingham. She also has an MSc in Translational Neuroscience and is the founder of NMN Bio. In this episode we talk about the details of the process of autophagy and how does it work. Timestamps: How Elena Became an Autophagy Researcher 01:05 What Is Autophagy 04:00 Why Is Autophagy Important 06:25 When Is Autophagy Not Good 11:11 What Activates Autophagy 12:12 How to Measure Autophagy 16:50 NAD+ Role in Autophagy 26:55 What Increases NAD+ Levels 30:20 Negative Effects of NAD+ 31:35 NAD and Aging 36:35 Best Ways to Activate Autophagy 41:21 Melatonin and Autophagy 45:10 Trehalose and Autophagy 46:30 And much more Self Decode is a genetics decoding company. You can get personalized health recommendations based on your DNA and the latest scientific research. They have numerous different DNA reports for different areas of focus like weight loss, longevity, gastrointestinal health, cognition, and even mood. Recently Self Decode came out with their 2.0 software that incorporates artificial intelligence in generating DNA reports. It's the most advanced and comprehensive consumer DNA service in the world. You can get a 10% discount with the code SIIM at get.selfdecode.com/siim Head over to get.selfdecode.com/siim and use the code SIIM for a 10% discount on your personalized DNA reports. Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body.  With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That's an AMAZING value. And I promise that deal is ONLY available on this specific website,  Click Here to Support the Show on Patreon!   Show Notes Elena Seranova Twitter NMN Bio Website Lucas Aoun's Natural Testosterone Optimization Course 10% OFF The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim          

Steve DavisProfessor Stephen Davis AO is a professor of Translational Neuroscience at the University of Melbourne, Director of the Melbourne Brain Centre at the Royal Melbourne Hospital and a Past-President of the World Stroke Organization. He co-chairs the Melbourne Mobile Stroke Unit program and is co-chair of the Australian Stroke Alliance, a powerful collaboration dedicated to improving the care of the growing number of people suffering stroke pre-hospital in the air and on the road. He is also my dad.Neon TreehouseI'm really pleased to announce that Humans of Purpose has partnered with digital agency and major season sponsor, Neon Treehouse. Neon Treehouse are a bold and creative team, delivering bright and imaginative solutions in the digital space.Got Purpose?The Purpose is our periodic e-newsletter, providing you with Humans of Purpose updates and a much needed dose of inspiration and growth-oriented material. Sign up here to avoid disappointment.Community PoweredHumans of Purpose is independent and locally produced. We are funded and supported by our generous community of listeners. Welcome to Michael who joined our community this week. A big thankyou goes out to our amazing community of Patreon supporters:Pasky, Jasmine, Deb, Joel H, Clyde, Carmen, Sue, Levi, Bee, Lyndon, Joe & MichaelWithout your support we wouldn't exist. Patreon support covers the majority of my monthly costs of production and enables me to improve podcast quality and to secure top quality guests. Have you thought about supporting us? Your SupportBecome a Patreon Supporter today for as little as the price of a single coffee per month. I'll send you an awesome exclusive Humans of Purpose tote bag (valued at $25) and you will help shape the podcast moving forward. See acast.com/privacy for privacy and opt-out information.

On this week's The Sci-Files, your hosts Chelsie and Danny interview Varshini Perumal. Varshini is a 2nd-year undergraduate student studying neuroscience at the College of Natural Science. She has been doing Alzheimer's research at the Department of Translational Neuroscience in the MSU College of Human Medicine for around 1.5 years, assisting Dr. Gordon's research.For the past year, Varshini Perumal has been working to investigate the presence of specific proteins present in the brain of individuals with Alzheimer's Disease contributing to cellular senescence. Cellular senescence is a phenomenon characterized by a cell's inability to progress through the cell cycle.  Senescent cells secrete inflammatory mediators and could contribute to aging-related diseases such as Alzheimer's disease. The purpose of her experiment was to investigate whether cellular senescence occurs in the brain during aging and if cellular senescence is associated with neurofibrillary tangles caused by the protein TAU's presence. The lab has previously demonstrated that these mice develop an age-dependent accumulation of neurofibrillary tangles. In order to do so, she used transgenic mice that over-express the Alzheimer's disease-associated protein TAU. This experiment suggests that Alzheimer's patients expressing more TAU would show more cellular senescence, leading to increased neurodegeneration in the brain. If you're interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at scifiles@impact89fm.org. Check The Sci-Files out on Twitter, Facebook, Instagram, LinkedIn, and YouTube! 

Prof Grainne McAlonan, Professor of Translational Neuroscience in the Department of Forensic and Neurodevelopmental Sciences at King's College London. Synopsis: Autism Spectrum Disorder (ASD) is clinically diverse, and its etiological mechanisms are poorly understood. To inform prognosis and generate intervention opportunities we need a better understanding of causal pathways; and subsequently, a means to examine target engagement. There is fresh hope however, based on evidence that multiple risk factors for ASD and related neurodevelopmental conditions converge to disrupt the balance between excitatory glutamate (E) and inhibitory GABA (I). This will likely alter the activity and structure of brain circuits which underpin (especially social) cognition and behaviour. Professor McAlonon’s research is directly testing this hypothesis by using MRI to examine spontaneous functional activity and microstructure in the brain of neonates with and without vulnerabilities for neurodevelopmental disorders. Her research has also begun to investigate whether E/I differences persist into adulthood in ASD, and if they are ‘responsive’ to pharmacological modulation. In her keynote talk, Professor McAlonan will share some of her early progress in these areas. Biography: Professor Grainne McAlonan studied Medicine at University of Cambridge and Imperial College London and completed a PhD in Behavioural Neuroscience at University of Cambridge.  After clinical and research posts in the UK, she worked for over a decade in The University of Hong Kong before returning to the IoPPN. She uses MRI as a translational tool to link brain and behaviour in people with neurodevelopmental conditions such as Autism Spectrum Disorder (ASD); and to ‘back’ (and ‘forward’) translate to laboratory models. Her current research is informed by her work in the National ADHD and Autism Service for Adults at the South London and Maudsley NHS Foundation Trust (SLaM) and she is Clinical Disorders Cluster Lead for the NIHR-Maudsley Biomedical Research Centre. Professor McAlonan is a group leader within the MRC Centre for Neurodevelopmental Disorders at IoPPN and is a lead investigator within the EU-AIMS-2-TRIALS consortium – a European network hosting the world’s largest grant for autism research. She is responsible for fetal/neonatal/infant brain imaging studies of children vulnerable to neurodevelopmental conditions and for pharmacology studies in adults with ASD.

From our physical appearance to our body's mechanical functions, our whole being is encoded into our genes and kept in each cell that makes us. These basic biological units have their system to keep everything functioning and our body alive and moving. They have housekeeping functions: cells perform autophagy to get rid of accumulated waste materials. Maximising the effects of these processes can help in increasing your longevity. When the autophagic processes fail, it can damage important parts of the cell such as the DNA and accelerate ageing. In this episode, Dr Elena Seranova explains the science behind autophagy and how it connects to NAD and sirtuin genes. She also shares her own experience and research on using this knowledge to live a longer, fuller life. Join us in this episode to learn more about autophagy and how this process is useful in increasing your longevity and giving you a boost in life.   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health program that is all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to https://www.lisatamati.com/page/epigenetics-and-health-coaching/. You can also join our free live webinar on epigenetics.   Online Coaching for Runners Go to www.runninghotcoaching.com for our online run training coaching.   Consult with Me If you would like to work with me one to one on anything from your mindset, to head injuries, to biohacking your health, to optimal performance or executive coaching, please book a consultation here: https://shop.lisatamati.com/collections/consultations.    Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research, and incredible tenacity to prove them wrong and bring my mother back to full health within 3 years. Get your copy here: http://relentlessbook.lisatamati.com/  For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.    Here are three reasons why you should listen to the full episode: Discover how cells stay healthy. Find out Dr Elena's tips and advice in increasing your longevity by activating autophagy. Learn more about the science behind NMN supplements and their revitalising effect.   Resources Read about Dave Asprey’s work around the keto diet. Lifespan by Dr David Sinclair Pushing the Limits Ep 170: The Search for the Perfect Protein with Dr David Minkoff Visit NMNBio if you want to learn more about NMN supplements in New Zealand.   Episode Highlights [04:33] Getting to Know Dr Elena Seranova Dr Elena Seranova is an interdisciplinary scientist.  She holds a degree in Psychology, MSc Translational Neuroscience, and a PhD focusing on autophagy and cell biology. With her expertise in her field, she co-founded a biotech startup and is now the the founder of NMN Bio in the United Kingdom.  [06:06] What Is Autophagy? Autophagy is a catabolic pathway that degrades unwanted materials within the cell. The cell needs to avoid the build-up of unnecessary materials. There are different pathways for activation like mTOR (mammalian target of rapamycin) and PI3K (Phosphoinositide 3-kinase). Impairments at various stages of autophagy lead to its failure and cell death. Once autophagy fails, apoptosis, or programmed cell death, can activate. [11:25] NAD as Fuel for Sirtuin and PARP PARP and sirtuin are different classes of enzymes that use NAD for multiple vital processes, including DNA repair (both) and gene expression (sirtuin). Sirtuin 1 is one of the pathways that can initiate autophagy. initiates the autophagic process. When DNA is damaged, PARP activates and depletes NAD stores. The decrease in NAD levels inhibits sirtuin's ability to carry out its functions, including autophagy, accelerating a cell's death. [15:34] What Is NAD? Nicotinamide adenine dinucleotide or NAD is a substrate for enzymes. It plays a vital role in different reactions within the cell. You can supplement NAD levels using boosters such as nicotinamide mononucleotide (NMN). [18:44] mTOR-Independent Pathways Activation of autophagy using Sirtuin 1 is an mTOR-independent pathway. It is essential not to activate autophagy through mTOR pathways. mTOR is responsible for cell growth and translation. [25:04] How to Activate mTOR-Independent Autophagy Autophagy is dependent on nutrient starvation. Intermittent fasting can activate it. A generally healthy lifestyle includes supplement intake, proper sleep, and healthy foods. Avoid too much sunlight because it damages the skin and DNA. It activates PARP enzymes. Take a tablespoon of extra virgin olive oil which contains oleic acid. This good fat has the same effects as resveratrol. Induce artificial stress through cryotherapy, saunas, and exercise to activate sirtuin 1.  [33:22] Why Did Dr Elena Decide to Bring NMN to the Market? She came across NAD and NMN during her doctorate studies and saw their importance. Her own experiences showed better focus and energy levels after taking NMN supplements. There are not enough reliable suppliers that offer good regulation and quality control. She wanted to provide the best for herself and her family. NMN Bio has complete transparency on suppliers and quality regulation [38:28] Can Weight Loss Occur from Taking NMN? Lisa Tamati's experience in taking NMN shows fat loss but no muscle loss. Dr Elena's mice studies show evidence that NMN can improve insulin sensitivity and lipid metabolism. [40:42] Do NMN Supplements Have Any Downsides? They found no side effects in studies with mice despite an increase in dosage. Current studies are still ongoing to determine the ideal dosage for humans. Most people take 500mg to 1g. Doubling this still shows good tolerance. Take supplements in the morning as NAD affects the circadian rhythm. [53:57] How Do Autophagy, NAD and Sirtuin Genes Fit Together? Autophagy recycles various damaged organelles. Sirtuin 1 genes activate autophagy and mitophagy. NAD functions as a substrate for sirtuin enzymes to work. NMN supplements can increase NAD levels. Listen to the episode for the full explanation of how these three work together. [58:43] Can NMN be Taken as an Infusion? This is not something that Dr Elena has studied in-depth and she is curious as well about how viable this procedure will be.  There is a low concentration of energy in intravenous injections, but it's present. Oral administration is more reliable in giving boosts and it costs cheaper. [01:00:01] Do Antioxidants Help in Increasing Your Longevity? Studies have shown that antioxidants don't suppress ageing. Lifestyle intervention and autophagy activation are proven ways to slow ageing.   7 Powerful Quotes  ‘Lysosome is another acidic organelle that contains acid hydrolases that are able to digest this cargo...and if it doesn't work, well, the cell is basically in trouble because you have all this garbage floating around, and there is nothing to remove them. So this is why autophagy is important. ‘When things are preserved across species, then that gives a scientist an indication that this is probably a very important biological function’. ‘I think that in order for your body to function properly, you really need to have a kind of a healthy routine in general’. ‘So I think that when it comes to being healthy, and activating your autophagy levels, and having a healthy lifestyle in general, you need to start with the basics first.’ ‘Another small tip that I can give is to actually avoid sunlight, which is something that people don't really consider. What happens when we're exposed to sunlight, when our skin is exposed to sunlight for prolonged periods of time, we start getting the DNA damage’. “The important part is not to just increase your age, it’s to increase your healthspan.”  ‘And if you have if your mitochondria are not healthy, and they're dying, and you're not having enough mitochondria in your cells, then you are going to be sick.’   About Dr Elena Seranova Dr Elena Seranova is a scientist, serial entrepreneur and business mentor who has founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. She started a private practice before developing an interest in neuroscience. She continued her studies and earned her Master’s Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Her expertise in these fields has led her to become the co-founder of a biotech start-up, SkyLab Bio. She has written a number of peer-reviewed articles and multiple research articles on autophagy throughout her career. Aside from these accomplishments, she started her own business, NMN Bio. Her own experiences with the use of supplements have inspired her to expand the market to supply the public with cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, UK, and Europe.  Dr Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr Elena and her work, visit her website.    Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends, especially those interested in increasing their longevity, so that they can practice the activation of autophagy in their lifestyle. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa   Transcript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential, with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Well, hi everyone and welcome back to Pushing the Limits. This week I have Dr. Elena Seranova, who has already been a guest on the show. And today, we're talking about autophagy and NAD, and the interplay between these two. Now that might sound extremely boring, but it isn't. It's all about longevity and anti-aging. So, we're going to be talking about the science between about NAD precursors and the sirtuin genes, and how to upregulate the sirtuin genes, and all about autophagy, which is really the recycling of old and damaged parts and proteins of a cell that need to be gotten rid of. So, it's a bit like having a good garbage disposal unit happening. And there are many ways to activate autophagy, which we go into in this episode. We talk about intermittent fasting, we talk about cold and hot and hormetic stressors like exercise and yes, of course fasting. But also, mTOR independent pathways to activate autophagy, it'll all be revealed in this interview.  Now this does get a little bit technical in the first 20 minutes or so. But hang in there and listen to this a couple of times. Because if you want to slow down aging, if you want to slow down the generative decline of your body and you want to have a long and healthy lifestyle, then this stuff is really, really worth paying attention to and trying to understand.  We talk about NMN, which is nicotinamide mononucleotide, which is a supplement that is now available, is a longevity compound to upregulate the sirtuin genes. And we're really lucky to check that out. You can go and find that supplement, which has been made and produced by Dr. Elena Seranova and her company, NMN Bio. So if you head hop over to nmnbio.nz, we're now importing this into the country. So, this is one way that you can really fight aging and degenerative decline that we all fear and don't want.  And when you listen to this episode and really listen to it a couple of times, you'll understand some of the incredible anti-aging things that are coming down. This is not pseudoscience. Dr. Elena is one of the most amazing neuroscientists out there. So please listen to this episode, enjoy it, get a lot out of it and get the takeaway. So, if you don't understand some of the terminology, don't worry, keep going. And by the end, you'll start to pick up certain bits and pieces. And if you listen to it again, you'll be able to pick up a little bit more and a little bit more. And at the end of the day, it's about the takeaways, what can you do to slow aging down and all that information is in there. So, I hope you enjoy this episode with Dr. Elena.  Before we go over to that we are all about health optimisation, high performance, athletic performance. So, if you need any help with any of those areas of your life, please reach out to us, Support at lisatamati.com. Go and check out our website, lisatamati.com. You'll find all our programs, our Epigenetics Programs, our online run training system that's customised and personalised totally to you, and check out what we do. We love helping you be the best version of yourself that you can be. Now over to the show with Dr. Elena Servanova.  Lisa: Well, hi everyone. Lisa Tamati here and very excited to have you hopefully join us this morning. It's 7:30am in the morning here in New Zealand. And where Dr. Elena Seranova is, it's very late at night. How are you doing, Dr. Elena?   Dr Elena Seranova: Good, good. How are you? Happy to be here again. Lisa: Yeah, very excited for today's topic. So, we're going to be doing a discussion around autophagy and NAD boosters and sirtuin genes. So it’s going to be a really interesting discussion that is really beneficial for you if you want to know how to live longer, live healthier, and optimise your body and your mind and your potential. So, Dr. Elena, can you just tell us briefly a little bit about yourself?  Dr Elena: Sure. So, I started my journey as a psychologist. So I'm an interdisciplinary scientist. I majored in psychology at first and then I had my own private practise for five years which turned out to be a successful wellness centre. And I really got fascinated by neuroscience and the brain. And for this reason, at first I started studying the brain myself and then I found an amazing master's degree at the University of Sheffield in Translational Neuroscience, which basically combined the research and neurodegeneration with applications that could translate into therapeutics. So, this is what translational neuroscience means, is basically the combination and the outcome of the research—the hardcore biology research that can be utilised for therapeutic approaches and patients.  I really enjoyed that. So that was quite cool, being in the lab and doing molecular biology experiments and so on. So, I kind of fell in love with the lab, and I decided to do a PhD as well. I continued my studies in autophagy and stem cell biology and it was quite challenging, but at the same time, I really enjoyed it. And I can definitely say that science is a big part of my life. Lisa: Definitely your thing. Okay, so autophagy and stem cells. So in relation to neurodegenerative diseases in that case? Okay, but what is autophagy? Because a lot of people will be listening to it and go, ‘What the heck is that big word, autophagy’? It's sort of big word in biohacking circles, but perhaps not in the general public. Can you explain what autophagy is exactly?  Dr Elena: Yes, sure. So, autophagy is a catabolic pathway that degrades dysfunctional organelles in the cell or protein pro aggregates. So, any material that is basically unwanted in the cell, autophagy can degrade. It's like the stomach of the cell.  Lisa: So, it’s like eating it? It's eating, sort of...  Dr Elena: Yeah, exactly. And what happens when autophagy is activated, we actually have the formation of the so-called phagophore, which is a membrane structure that basically engulfs different organelles and materials that need to be degraded to form the so called autophagosome, which is a round organelle that basically has this cargo that needs to be digested. That eventually fuses with lysosome.  And lysosome is another acidic organelle that contains acidic hydrolases that are able to digest this cargo. And this process is very essential for the cell, it’s very vital. It's evolutionary conserved in all species, from yeast to models. And if it doesn't work well, the cell is basically in trouble because you have all this garbage... Lisa: Floating around.  Dr Elena: ...floating around and there is nothing to remove them. So, this is why autophagy is important. And we have different pathways that autophagy can be activated through as well. So, one of those pathways is mTOR, mechanistic target of rapamycin. And then we have other pathways that can activate this process such as AMPK, GSK3, and so on.  Lisa: So is this like, sorry to interrupt, but like because I know that people out there might be like, ‘Wow, that's a lot of big words and a lot of information’. So, is it like that the cell has to do a housecleaning, and it's got stuff inside the cell that is not working optimally, and needs to be gotten rid of, or is it the whole cell? So, it's not apoptosis. So it's not where the host is disintegrating? Dr Elena: No. Yeah, it's actually a—it's a pre-apoptotic pathway. So, before apoptosis is activated, we have autophagy. And if autophagy fails in what it needs to do, then we have activation of some apoptotic pathways. So, it's one step before that. And if everything goes well, and autophagy is functional—and by the way, in different diseases, we might be having different autophagy impairments at different stages of autophagy. So, it's either the initial phagophore formation, for instance, that it's not working well, and it can’t engulf the cargo, or it's insulator stages of autophagy, such as the acidic hydrolysis and the lysosomes that are actually not that acidic. So their pH is not acidic enough to digest the cargo. So, we might be having different defects in the autophagy pathway in different diseases. Lisa: That leads to apoptosis. Am I right?  Dr Elena: And yeah, if autophagy is not doing its work correctly, then eventually we will have apoptosis. And actually, this is what we're seeing in in vitro models of neurodegenerative diseases as well. So, for instance, if autophagy is not working well.  And we have, let's say, dysfunctional organelles, such as mitochondria—dysfunctional mitochondria that are not working well. Let's say they are depolarised. And there is an excess production of reactive oxygen species going on. Now, if nothing can degrade these dysfunctional mitochondria, you'll keep on having this accumulation of reactive oxygen species, which eventually will lead to DNA damage and deactivation of PARPs. And it's basically a death spiral that will keep on leading the cell towards death.  Lisa: Okay, so what is a PARP? You mentioned PARP there. And just for the listeners, too. So, apoptosis is basically cell death, programmed cell death. So, this is not—what's the other one necrotic or something?  Dr Elena: Necrosis?  Lisa: Yeah, necrosis, where the cell dies for—necrosis. But this is sort of a natural programmed cell death. But we only want that if we're actually renewing the cells and we are wanting new stuff. So, before that, the body tries to do this autophagy process, is that how it works? And then what so what is PARP? What is PARP, because that’s the word again... Dr Elena: PARPs are a class of enzymes, and in order for them to function, they need a molecule called NAD, so nicotinamide adenine dinucleotide. And they're actually competing for NAD in the cell. And whenever we have increased DNA damage, we would have the PARP activation as well. And this would lead to NAD depletion, which kind of brings me to my next point about what other enzymes consume NAD. And one of those enzymes are sirtuins, which are the so-called longevity genes that are basically responsible for multiple processes in the cell, including epigenetic regulation of gene expression.  So, they do—because sirtuins are a class of enzymes that are also dependent on NAD, and they're all the deacetylase enzymes, meaning that they remove acetyl groups from the DNA. And as a result, they control which genes will be expressed in which tissues, which is very crucial for the cellular identity and for the proper function of different cells.  So, sirtuins in a healthy cell, so sirtuin should be upregulated and they should be having this housekeeping gene—housekeeping function where they basically control what's going on with the DNA repair and also with the gene expression as well. And if we do have—when we do start having impaired autophagy, and let's say there is increased reactive oxygen species, because there are increased dysfunctional mitochondria in the cell, you will have in more activation of PARPs, and all of the NAD will start being drained from... And sirtuin will not have enough energy to function. So, those are actually quite an elegant interplay between autophagy and NAD and sirtuins.  Lisa: Okay. Okay, can I just want to like put that back to you, so that we can slow down because we are going technical quite fast. And I think a lot of people might be like, ‘What the heck are they talking about’? So, the sirtuin genes, basically longevity genes, and then one of the jobs is DNA repair. And another of the jobs is to say which genes are actually being activated right now. And these sirtuin genes are also responsible, I think, for cell replication, is that correct? Dr Elena: The sirtuins are responsible for multiple functions, directly or indirectly. So, for instance, the sirtuin 3 gene is also responsible for mitochondrial biogenesis. And it's implicated in the amount of mitochondria that are being produced by the cell, which is related to cell replication eventually, because you do need to have enough ATP levels to replicate. Lisa: Right. Yeah. So, this has definitely to do with ATP production as well and mitochondrial health. So, these are doing all of these jobs, the sirtuin genes, they're very, very crucial genes in our genome. And these are preserved across every species, I believe? Every species on the planet?  Dr Elena: Yeah. Also from yeast to humans, it's also—sirtuin genes are preserved very well. Lisa: And when things are preserved across species, then that gives a scientist an indication that this is probably a very important biological function and we need to have a look at this one because it's—from what I understand.  Okay, so when you have activated PARP because you're not doing autophagy well and there's things going wrong, it's taking the NAD. So NAD is basically like a fuel source that both the sirtuin genes. And when PARP is activated, it's using to fuel its job. And so, this is competition for competing fuel sources. So, like if you imagine, you've only got one tank of fuel for your car, but you've got to go in two different directions and do two different jobs. You go, ‘How am I going to divide up my energy’? So, then it becomes important as to how much NAD we have in the body? So, what is NAD again? That says nicotinamide adenine dinucleotide? But what is that and how does it work?  Dr Elena: Yeah, it does serve as a substrate for all of these enzymes, including sirtuins and PARPS and is basically a master regulator of metabolism. So, it's a very important molecule and it serves as—without NAD, the cell is not able to function properly just because this crucial molecule is implicated in so many different reactions. So, NAD is found in all living cells and organisms. This is also evolutionary conserved across species. And it exists in two forms, NADH and NAD+, which is the reduced and the oxidised form, respectively. And both of them are important. And both of them are implicated in multiple cellular reactions.  Lisa: Is it going backwards and forwards in a cycle, NADH, NAD+, by donating electrons back and forth, sort of thing?  Dr Elena: Yeah. Through electron transport chain in the mitochondria, yeah. So, this is why it's so important. And so, what we're seeing now in the latest advancements in longevity research is that we actually can supplement with different precursors of NAD, such as nicotinamide mononucleotide, for instance, NMN. And this is the supplement that my company...  Lisa: See, you've now got that available on the market because this is such a crucial thing. Dr Elena: Exactly. And I think that it's really interesting to also say that when it comes to the interaction between autophagy and sirtuins, there is also another regulation of autophagy there. So sirtuin 1 is actually responsible for activating some transcription factors such as TFEB and FoxO3 that have to do with initiation of the autophagy process.  So, for this reason, when we do have dropping levels of NAD, decreasing levels of NAD, and there is not enough NAD for sirtuins to do their job. And let's say again—let's talk about that previous example in neurodegeneration when you have increased reactive oxygen species, and you have increased the level of stress and oxidative stress and decreased activity of sirtuins.  And not only the situation is already bad, but because sirtuin 1 doesn't have enough energy to function and to activate the TFEB and the FoxO3 transcription factors to initiate autophagy, now you have all of this dysfunctional mitochondria floating around and autophagy starts being impaired as well because we activated enough. So, it's a negative feedback loop which actually accelerates the scenario where the cell is going towards cell death, basically. Lisa: So that means like, if you don't have enough NAD, then your sirtuin 1 gene is not going to be able to initiate autophagy and clean up the cell and you're going to have dysfunctional mitochondria. Is that independent of the mTOR pathway? Or is that—am I getting confused?  Dr Elena: So, okay. So, good question. So, what happens is there are some molecules that activates sirtuins. So, for instance, sirtuin 1 is activated by resveratrol, and this is something that has been demonstrated many years ago. So, when you have sirtuin 1 dependent activation of autophagy, you will be having it through an mTOR independent pathway. Lisa: So it's a fasting mimetic resveratrol.  Dr Elena: Yeah, yeah. Yeah, absolutely. So, because we now know that the mTOR activity is not affected by intake of resveratrol. And this is quite crucial because actually, even if we want to activate autophagy, we shouldn’t do it through the mTOR pathway, this is not the preferred way, because mTOR is also responsible for growth and translation in the cell. So, this is not—it's also quite a key player in the cell. So it's a serine threonine kinase, and you actually don't want it to be activated at all times because this may lead other conditions. So, what we're focusing on at the moment is to find molecules that can activate autophagy in an mTOR independent manner. Lisa: Okay, so. So if the mTOR—cause MTOR is usually what's for growth it’s anabolic, it's causing growth. So for example, a bodybuilder goes to the gym, they're in an anabolic state, they are in an mTOR growth state. And when you have autophagy, that's sort of the opposite. So, it's a catabolic state where it's starting to eat itself. So, it’s mTOR, most people like do fasting for that reason to activate autophagy? Dr Elena: Yeah, this is another good point there. So, when we're fasting, and there is actually conflicting evidence out there as to when autophagy is fully activated. Usually, people say that around 24 hours, you start having the autophagy activation. There are others that swear by the ketogenic diet, and say that if you don't consume any carbs, you will get autophagy activation anyway. However, from what other researchers have found is that, if you are in a ketogenic diet, and you do consume meat, it depends on what kind of meat you consume that will either activate autophagy or not. And it all has to do with levels of different amino acids in the cell because autophagy is quite sensitive to nutrients and to nutrient starvation to be activated. If you have an abundance of amino acids, again, it will not be activated.  So, for instance, one amino acid that activates autophagy very well is leucine. And if you're eating certain meat that are rich in leucine, this is probably not good for your autophagic state. Something else to keep in mind, and I've heard, I think it was Dave Asprey saying that if you can manage to be on under 15 grams of protein per day, you will probably keep the autophagy going.  Lisa: Because a lot of people on keto think I can eat a lot of protein, which is a mistake, really. It isn't about having—that's interesting, because I had Dr. David Minkoff on my podcast, Pushing the Limits a while ago, and he has a product called PerfectAmino, which is really a 99% usable form of amino acids and combination. And I was interested, ‘Well hang on, if I'm heading there, which is going a lot of good things in the body. But is that going to inhibit my mTOR, or autophagy’? Sorry, because I've got too much leucine in there? Dr Elena: This is a very good point for all of this process food as well. So, for instance, there are some ready meals you can get or some protein bars that claim to have all the low carb and everything. And then they slam a badge on their pack saying that it's vegan as well. But then, why is it vegan if it has all the amino acids because that's one of the selling points when you're actually on a vegan diet, or you have some days where you are on a vegan diet. You want to get yourself in a state of partial amino acid depletion to get this beneficial effect of enhanced autophagy. And on intercellular toxins and so on.  Lisa: Right, so for certain periods of time, you want to do this, and it's a cycling thing, you don't want to be completely deficient of aminos for too long because then your body will start to break down. Dr Elena: This is what I do personally as well. So, during the week, so I am a fan of cattle/carnivore diet. So, this diet is quite comfortable for me and I enjoyed it quite a lot. But then during my week I try to have some days where I'm either vegetarian or vegan, just because I want to have those benefits.  Lisa: Yeah. Up and down. And then this seems to be a theme in biology all the time is that it's not one thing. It's not staying on keto for ever and ever, amen. It's about doing cyclic keto or cyclic vegan and it’s cyclic. And our body loves this push and pull—when there’s recovery and there’s growth and then clean up phase, growth clean up. So autophagy can be activated through fasting. It can also be active through having resveratrol and upregulating the sirtuin 1 gene, how else can we activate autophagy? Dr Elena: So there are different ways, there are different things you can really implement in order to activate autophagy. And I think that it all has to do with how you build your lifestyle in general. So, I think that in order for your body to function properly, you really need to have a kind of a healthy routine in general. And an analogy that I can give you there is that there are people that would buy a couple of supplements, and then they would be so proud of it. And then they would say, ‘Oh, yeah, but I'm taking those supplements now, and I'm so healthy’. And then their biorhythms are all off. They sleep at 5am every day. And they're eating crappy foods or super processed foods.  Lisa: Yeah, it’s not going to work.  Dr Elena: It’s all good. So, I think that when it comes to being healthy and activating your autophagy levels and having a healthy lifestyle in general, you need to start with the basics first.  So, the intermittent fasting is definitely the first step to take in order to become a bit healthier. And from the research that I'm reading, and from the things that I'm implementing, I definitely believe that both anecdotal and scientific evidence point towards the fact that intermittent fasting is actually the way to go. I mean, there are conflicting opinions out there and there are pros and cons in every diet, and so on. And I get that. But I personally believe that with intermittent fasting, if you try to narrow down the window where you're uptaking food, this is very, very good for you. So, this is step number one.  But then again, so either you're trying to raise your NAD levels, or you're trying to activate your autophagy, because those pathways are quite intertwined. And what you eventually want to do is you want to have increased levels of sirtuin, and sirtuin 1 in particular, and sirtuin 3, of course, and so on. And for this reason, in order to preserve this pool of NAD that is available for the sirtuin 1 to activate itself and activate the autophagy pathway.  Another small tip that I can give is to actually avoid sunlight, which is something that people don't really consider. But what happens when we're exposed to sunlight, when our skin is exposed to sunlight for prolonged periods of time, we start getting the DNA damage. And when you get the DNA damage, you have PARP activation, and then again, you NAD pool... Lisa: Wow. I never connected those dots. That's really interesting. So, because—I mean, we need sun. We need sun for vitamin D and for our mood and all that sort of stuff. So, you're not saying don't have any sun.  Dr Elena: Yeah, sure.  Lisa: But because the sun is causing DNA damage, it's going to cause more PARP activation, it’s going to have the sirtuin genes going to repair the DNA, that's going to use up the body's resources is what you're saying.  Okay, wow, that makes sense. Makes sense. And then by the same token, like things like smoking that breaks DNA, like no tomorrow. This is why smoking ages you is because of all the DNA breaks. And this is why, when you're in the sun for hours every day, you get wrinkly skin and you get collagen lost and all the rest of the things that are happening. So, anything that's going to be causing DNA breaks is going to cause you to age quicker.  Dr Elena: Exactly.  Lisa: Using up the resources basically. Wow, okay. Dr Elena: So it's obviously—you don't have to become a vampire and dissipate walk in the sun when you want to go somewhere. But sunbathing for hours is definitely not something you want to do with—to get your body go through, basically. So that's another tip.  And then something else, really, really simple that can be implemented on a daily basis in order to maintain your sirtuin levels, and as a result, your autophagy levels, and your NAD levels is also to take a tablespoon of extra virgin olive oil, which contains oleic acid. And it basically does the same job as resveratrol. And it's interesting—I think that there's been a recent research article out that shows that like oleic acid might even be more efficient than resveratrol, in terms of activating sirtuin 1, which I think it's really, really cool.  Lisa: So yeah. Well, combine the two. I do. Dr Elena: Yeah, absolutely. You can do that. And then, you need to make sure that the extra virgin olive oil is actually of a very good quality because there is a bunch of...  Lisa: There is a bunch of rubbish out there. So, make sure it's from an orchard that you know, it's cold pressed, it's all those extra virgin, it's all that sort of good stuff. And not—how do they do it with solvents and stuff? Or that it's come from multiple orchards and being cut with other oils. It's a really, really important point. And then oleic acid does so much good things in the body. But isn’t that fat, Elena? Like lots of people are like, in their minds are going, ‘But oil is fat. It’s the same with MCT oil. Isn’t that going to make you fat when you eat fat’? Just going to put that around.  Dr Elena: There are good fats and there are bad fats. So, olive oil is good fat. MCT oil is a good fat. Avocado is a good fat. So, not all thoughts are made equal. So, this is definitely something important to keep in mind, especially with a good quality extra virgin olive oil.  Lisa: Because each one of our cells is a membrane that has a phospholipid, isn't it? So we need that,  actually, this building of ourselves into the integrity. Dr Elena: We have a phospholipid layer in the brain as well. And this is why we actually supplement with omega 3 fatty acids, because this is what it does. So, this is what omega 3 fatty acids do. They go into the phospholipid membrane, and then they basically... Lisa: Make the integrity of that membrane better. Dr Elena: Yeah, they contribute to the healthy phospholipid layer in the brain.  Lisa: So that's why it's very important for neurodegeneration to have omega 3s going in and again, people get quality omega 3s. Not your cheap supermarket ones that are perhaps oxidised and have been sitting on the shelves for six months. So really important to get a reputable source here. And omega 3 is of course in fishes as well, and krill, and so on.  Okay, so but is there a downside to fat? Because I studied epigenetics and a lot of people's profiles come back with don't have too many fats. And it's been one of those things in my head is like ‘Why would some people not come back with you shouldn't have too much fat’? I mean, there are things like gall bladders been removed. That's a pretty specific thing. But is there a genetic component? And probably not your wheelhouse, really, but is there a genetic component to your ability to process fat? Dr Elena: There is a genetic component, and I've actually seen this with a family that has a history of very problematic digestion of fat, and so on. Absolutely. But yeah, again, not all fats are made the same. And when you cut off the bad fats from your life, things change and everything changes really. Lisa: Yeah, it really is very satiating, too to have a little bit of fat and that can really help with cravings and blood sugar spikes—we're getting off topic.  So you have a company, NMN Bio, which produces nicotinamide mononucleotide supplement. And you've got a whole range of other stuff coming as well. Why did you decide like, you need to get this out there on the market? Based on your research and your knowledge around this area, why is it important that people take NMN if they're serious about slowing aging? Dr Elena: So first of all, I came across the biology of NAD and NMN during my PhD studies and my research kind of led me into this field because I was studying autophagy neurodegeneration. And actually, I still cannot disclose my research.  Lisa: Yeah, it’s not published yet.  Dr Elena: My research paper from my PhD is not published yet, but hopefully soon, so we're about to submit it quite soon actually. So for this reason, I started studying the biology of NAD and I actually saw how important and how crucial NAD is to the cell and what happens when we have a lack of NAD and depletion of NAD pools in the cell. And I've been supplementing with different kinds of vitamins and supplements my whole life really. So, I was watching closely this space for a while, and I was taking different supplements myself for a while.  And so, when I came across NMN and I realised that actually there is this strategy where we can supplement with a precursor in order to increase our energy levels, I found it really, really interesting. And I thought to give it a go myself and try it out and see the results. And then what shocked me was that the immediate effect of the supplement—so within a few days, you can already feel a difference in your energy levels and your focus. And this comes from the fact that sirtuins are responsible for so many molecular processes in the cell. And this is why you have this effect, including the mitochondrial biogenesis, which gives you basically increased ATP, consequently.  Lisa: You get actually more mitochondria. So, like, if you got heart disease...  Dr Elena: The production of more mitochondria, and then they produce more ATP as a result. And then you have this magic energy, yeah. This is why I thought to bring this product into the market. And the other reason was that there was not enough reliable suppliers on the market, which is crazy, because it's actually quite a popular supplement. It's been on the rise, the interest was rising for the past couple of years, but what we're seeing is there is a lot of white labelling companies that don't offer any certificates of analysis and so on. And also, you have even big companies not offering proper certificates of analysis, which was me like, it was…  Yeah, I don't understand. You have a big company, and you have just the purity report from like, 18 months ago, and you don't have any other analysis, such as heavy metals, or pH or microorganisms. So, the consumer is actually not confident in buying from you. And I wanted to deliver the best quality for myself and my family. And then I said, ‘Wait a minute. This is not done, right’. And this is why I launched the company because I wanted a company that was completely transparent. And I even say it on the website, that if you're interested in finding out who our suppliers are, and so on, and have any questions about our supply chain, just feel free to reach out to me. And I would be happy to disclose all of those things. There are other companies that you can't find any registration number, or who the founder is, and so on. And it's quite confusing, really, because like you— you don't know who you deal with.  Lisa: This is the same with the whole supplement industry. On the one hand, it's good that it's not regulated by the FDA, and whoever else, there are authorities around the world. Because like, then—they are turned into the pharmaceutical industry, which don't get me started. But on the other hand, there's not enough regulation around the quality control.  And one of the things when I was searching for NMNs, searching the world for it, I had to go overseas and import it to friends in America and get it out of there. And this is why I like—was super excited to discover your work. And then, we've since now made it available down here. So, we're going to branch down here in New Zealand for New Zealand, Australia. And I wanted someone who I could trust, who has all the scientific knowledge behind it, there's all lab tests, etc. And that was really important for me for quality.  Just on a side note. So I've been taking NMN now for—I think—so five, close to six months. I've had a massive weight loss and so as my mum. Why would that be? Like, I didn't take it for weight loss. I wasn't overweight, per se. But I had a couple of kilos that I was quite clear to get rid of. And what I've noticed—because I'm an athlete, that's my background—I haven't lost an ounce of muscle, which has been really awesome because most people are struggling to keep muscle mass, lose fat mass. My mum has lost 11 kilos. And she is of a genetic body type that really struggles with weight loss. She's conservation metabolism, from a genetic point of view, very, very hard for her to lose weight. So, I've never seen this in the history of her entire life, since I've been around. The weights just dropped off her.  Is this some sort of upregulation in the metabolic pathways? Is it improving the insulin resistance? What's it doing there to cause such weight loss without muscle loss? Dr Elena: Well, in my study so far, there's definitely evidence that it does improve insulin sensitivity, and it also improves the lipid metabolism profile. So those two are very important. And unfortunately, we don't have those studies in humans yet. But more clinical studies are on the way, and hopefully we'll have very good results this year with the NMN besides the safety studies that we already have in humans.  So in mice, what we're seeing is that there is basically a reverse of type two diabetes, which is really impressive. And if you want to correlate this data into humans somehow, I would say that, obviously, I'm not a medical doctor, and this is not a medical advice, but I would say that it does have to do something with the metabolism, and it basically improves the way your body metabolises everything. And...  Lisa: Worth trying and there's no downside to NMN. There's no, it's a vitamin B derivative, well then you will say to me, ‘Well, can I just take B3 and be done’? and it's like, no, it doesn't work like that, which should be a lot cheaper. Dr Elena: That’s the other impressive thing about this compound is that it actually doesn't have, if any, side effects at all. So even in studies with mice, where the dosage that they use in mice is actually much higher than it is in the one that we usually have in humans. So, for instance, if someone would take 500 mg, or one gram of NMN per day in humans. And then in mice studies, they use something like 200 mg per kilogram of weight, which is much, much more, and it still doesn't have any side effects. Lisa: Does it mean that we need higher dosages? Like in the human, or has it only been tested to one gram and why has it not been tested higher, if that's the case?  Dr Elena: No, I think that there are studies underway for this as well. So eventually, we will find what is the ideal dosage for humans. I think that from anecdotal evidence, people can already see results from 500 mg or one gram and so on. There are people that take more. So, some biohackers say that they take two grams or four grams, and is still very well tolerated. But yeah, so far, it does not produce any side effects in terms of… Lisa: Any downside. Dr Elena: Basically. And, for instance, for myself, my stomach is quite sensitive. So, when I'm on an empty stomach, I can't take vitamin C or caffeine and I get nauseous and so on. And this is not the case with an NMN. So, I can take it first. It is very well tolerated on an empty stomach, very mild. I really love it. There’s so many reasons to love it.  Lisa: Yeah, yeah, yeah, I have my morning and night. So, I'm on a gram a day. And is there any reason not to take it at night? So I split the dose—reasoning, thinking, keeping the levels up?  Dr Elena: I mean, I would probably take it all in the morning, I think. There's been a study out that it can affect the circadian rhythms as well. And interestingly, it actually affects NMN—sorry—NAD levels affects the circadian rhythm. But it's not the other way around. So, NAD actually dictates the circadian rhythm in the body. So, for this reason, I would suggest to take it in the morning because then your whole body synchronise, then you wake up and you tell to your body that look, it's the morning now, and we're going to have increased NAD level. Lisa: Increase. Ohh okay. So, okay, I got that wrong. I haven't noticed that I've had worse sleep or anything like that, or any rhythm has been out. But I would definitely swap to doing—my thinking process around that was keeping the tissue saturated over a 24-hour period, as opposed to all at once and then perhaps dropping, but I don't know. What is the half-life of it? Do you know? Is there any sort of evidence around that? Dr Elena: I actually, not sure. No, no.  Lisa: There’s no evidence yet. And so yeah, there's a ton of studies still being done that are currently, like this year, like going to be coming out, which is going to be really exciting. So that we're going to get more evidence. I mean, there's this stuff that I've been reading around fertility in animal studies, and they're starting to do human studies, which I personally am very interested in, in reversing aging of the ovaries and even with... I mean, the mice study was incredible around fertility, where the mice were postmenopausal, they actually knocked off any existing eggs with chemotherapy. And then gave them NMN and the mice went on to have babies. And there was a whole study. Dr Elena: This is why I get so excited about NMN and this is why it's my first product because frankly speaking as a scientist, I've never seen results like that with a natural compound.  Lisa: No? Dr Elena: Because there is a bunch of natural compounds out there, there is a bunch of other supplements. And what we're talking about spermidine the other day...  Lisa: Yeah, yeah, it's interesting.  Dr Elena: ...another autophagy activator. Quite an interesting supplement, yes. By the way, it's also an mTOR, independent autophagy activator, which is good. Lisa: Another very good reason to take that as well. And we were looking into that aren’t we, Elena about adding that?  Dr Elena: Yeah, absolutely. We will look into this, but again, you don't see results, like the ones that you see with NMN in multiple studies from other compounds, it's really fascinating. Lisa: Wow, so yeah, so there are other products that are going to... And this is a super exciting thing, like were our grandparents or our parents even didn't get the chance, like, with aging was aging, and there was nothing that you really could do to influence how fast you aged. They weren't aware of it. And later on, it's become well, if you eat better and you exercise a little bit more and you stop smoking and, and stuff, you’ll age slower. But now we're taking exponential leaps in our knowledge. I mean, I fell into this realm when I was reading Dr David Sinclair's book, who is a very prominent scientist at Harvard Medical School, and made his book, Lifespan, which I totally recommend people reading. I was just like, ‘Oh my gosh, if I can stay healthy now’, because I'm 52, ‘if I can stay like, really, in top shape for another 10 years, by then we're going to have stuff that will help me live really long’. And that really excites me. And not just live long, but live healthier.  Dr Elena: That’s the important part. The important part is not to just increase your age, it’s to increase your health span. So, the time that you're spending being healthy. And what you're referring to is actually called the aging escape velocity, where basically we’ll have more advanced research coming in every year of our lives. And this will eventually expand our lifespan, which is amazing. And I also think that if we preserve ourselves well, we might as well see this in our lifetimes, which will be amazing.  Lisa: Absolutely. And I want another few decades, please. Listening to Dave Asprey, who by far, got... Dr Elena: I want another like, few hundreds.  Lisa: Yeah, well, I mean, I know it sounds ridiculous right now. But if you listen to Dave Asprey saying conservatively, and Dr. David Sinclair, too, like, conservatively, we could live to 150, 180, and beyond. Then once they crack the code, and they're actually able to turn the cells back to which they are working on right now. And which they can actually go in the petri dish, from what I understand like with skin cells and make them immortal. And they can't do it in humans because it's too risky, they could turn you into a tumour and stuff. But with the Yamanaka factors that were discovered a decade or so ago, they're actually able to turn the clock back to the point of you being a 20-year-old again. And this is like, ‘Wow, this is pretty exciting. Being able to regrow nerves, spinal injuries, people who have gone blind from macular degeneration’ — all of these things are coming down the line. This is very, very exciting.  Dr Elena: There are several advancements in this field. So, as I said, my PhD is also in stem cell biology. So, I was working with human embryonic stem cells in the lab, and what they can do on a dish is just mind blowing. Because what I was able to do was to take human embryonic stem cells, and then dictate their fate, basically, with different growth factors, and then differentiate them into neural precursors at first. And then to push them further in order to become terminally differentiated neurons. And like four weeks later, you basically have a human brain in a dish and it's a primary human cells. And it's an amazing, physiological irrelevant human platform as well to study disease. And this is what I was doing during my PhD.  So, I’ve seen it with my own eyes. And every time I would do, I would go through this process, I would differentiate the human embryonic stem cells into neurons. It would be as exciting as the first time because of what it represents, because it does represent the progress that we've made so far. And I personally started human embryonic stem cells for the sake of drug discovery. So, I wasn't interested—my project was not focusing on different therapeutic applications. However, I know that there are many advancements in this field as well. So, we do have clinics in America, where you can have a total body rejuvenation, stem cells, and so on. And this technology is definitely advancing.  And I've been actually thinking about the application of this for myself. So as you know, I recently had a dental injury. This is something to keep in mind for the future. So perhaps in the near future, I can just inject myself with a bit of a stem cells there...  Lisa: And that’s already happening to a degree. I mean, I've got a doctor friend up north, who's doing stem cell replacement for joints, and so on, for degenerative joints. Because stem cells, basically, for people who don't understand why this is important. The stem cell is the original like cell, but before it decides, ‘Am I going to become a skin cell, or a neuron or a liver cell’, it differentiates. So, it's a pluripotent stem cell, it can become anything. And so, in the lab setting, you're going to be able to say, ‘Well I want your cell to become a liver cell’. Will we eventually be able to grow organs that can be used for transplantation? Is that sort of one of the end goals?  Dr Elena: Absolutely. And it's already been done with some organs. So for instance, I've heard that there is a research group that basically 3D-printed a functional thyroid gland from stem cells.  Lisa: Wow. 3D-printed. So, the printer gets these differentiated cells somehow, and then makes it into a functioning organ that they will eventually—they're going to be able to actually transplant this into people and save the whole organ donation, horrific troubles that we have currently.  Dr Elena: Yeah, exactly and I think that we're not too far away from this from whole organs being recreated in the lab. We already are able to actually do a 3D culture in the lab and create the so called organoids. So for instance, from stem cells, you can do a brain organoid, where you have a liposphere and it basically consists of different kinds of cells that you see in the brain. So it would have neurons, it would have glial, it will have astrocytes, and then it would have this brain organoid and then you can study it.  So, we're already getting there. We’re close, we’re much closer than we thought we were 20 years ago. And I think that we're not far away from having different kinds of organs being grown in the lab for transplants and so on.  Lisa: Hopefully not our brains because it's the seed of who we are. Honestly reading Dr Sinclair's book, I was like, ‘Am I in a Star Trek movie or something’? because it is pretty, pretty amazing. But when you do this, you also ask that to understand the whole process and how the whole thing functions, and then you can actually really slow down neurodegeneration and optimise things.  And so the NMN that we're talking about right now is the beginning of this really exciting road, which we're going to be staying abreast of. And hopefully adding to what we have available to the consumer right now for prices that are not moon money, that it's out of anybody's reach, but actually what you can do today so that you can preserve your health. So that in 10 years’ time, when the real crazy stuff starts coming on line, you'll be able to live longer and healthier lives. And that's the whole goal of it.  So before we just wrap up, I just wanted to reiterate again, so how is autophagy—can you just put that—how is autophagy related to NAD and sirtuin genes? Can you just put that two pieces together again, just repeat that a little bit? Dr Elena: Sure. So basically, what happens is that you do need autophagy to recycle different damaged organelles in the cell when something goes wrong. So, and this is quite prominent in neurodegeneration because the reason we have—let's say, aggregate from proteins in neurons and dysfunctional mitochondria and so on is because neurons are terminally differentiated cells. This means that they don't divide anymore. So, they rely on autophagy in order to have their housekeeping function because they can't divide the junk away. Okay. So that's the reason why autophagy is important in terminally differentiated cells such as neurons.  Lisa: So there's no hay flick limit for a neuron. There is just only one—when a neuron becomes a neuron, that's a neuron. Okay. Dr Elena: Yeah, yeah. And then that's it. And what happens with the activation of autophagy, one of the signals is—comes through sirtuin 1, which basically can activate the transcription factors that are related to autophagy activation, which is the TFEB transcription factor, EB and FOXO, which are basically influenced the activation of autophagy. And more specifically, the mitophagy as well. So, mitophagy is the arm of autophagy that is responsible for the mitochondrial clearance in the cell. Lisa: Yep, so mitochondria, just for people, are the powerhouses of the cell. This is where a lot of—so all of the energy is produced, if you like. And so, this is why mitophagy, as opposed to autophagy, so mitophagy is doing the same process, but within the mitochondria to keep your mitochondria healthy. And if your mitochondria are not healthy, and they're dying, and you're not having enough mitochondria in your cells, then you are going to be sick. And that could be heart disease, it could be neurodegeneration, that could be anything. So, keeping your mitochondria healthy is the basis of all bloody disease, blatantly.  Dr Elena: Yeah, exactly. So then, if you have impaired autophagy in the cell, and then you also have some sort of DNA damage going on, such as the one from reactive oxygen species, for example. And then what you have is the activation of the PARP enzymes. And PARP enzymes heavily rely on NAD levels in the cell in order to function. And NAD is also a substrate for the sirtuin genes that are responsible for also regulating a bunch of very healthy, a bunch of processes in the healthy cell. And for this reason, if you do have increased activation of PARPS, you will eventually get this NAD drain out of the cell. And this will not be enough in order for the sirtuins to function properly. And this will also deplete your autophagy. So, both NAD levels and autophagy are important to the cell. And fortunately for us, we can actually replenish the levels of NAD by supplementing with an ad precursor such as an NMN. Lisa: Okay, and so NMN has been proven to be by most of our bio available, because there's also like nicotinamide riboside which is used in a number of supplement companies that I know have nicotinamide riboside, but not many, there are some now, but have nicotinamide mononucleotide. Nicotinamide riboside is also a great molecule, but it's two steps away from becoming NAD. As long as it’s available.  Dr Elena: Yeah, so nicotinamide riboside needs to be phosphorylated and fast converted to nicotinamide mononucleotide first. And then this will enter the cell and then this will increase the levels of NAD in the cell. And for this reason—so first, this area of research was focusing on the NR molecule, the nicotinamide riboside. But then when they started studying NMN, they actually saw that there is increased bioavailability and there is increased levels of energy that come after supplementation with NMN. Lisa: Can you take—because NAD is a molecule, you cannot just take it as a capsule, and then it's all good to go. Can you take it as an infusion because I have heard of NAD infusions. I mean, it’s not available here.  Dr Elena: Well, and I'm curious myself about this, and I haven't done it, I haven't tested it. And from what I've seen—so the concentration of NAD in those intravenous injections is quite low. And I think that the same way that we have many opportunistic companies in the supplement field, we also have many opportunistic clinics that offer this kind of treatments. So, again, this is not something that I have studied in depth, and I actually don't know how much will it help. But yeah, I mean, this is another way to boost NAD, I guess, and you can try it out.  But with oral administration of NMN, we do have evidence that it can boost the levels of NAD in the tissue and in liver tissue and muscle tissue, and so on. And also, it's much easier to do and it's obviously much cheaper because those injections cost a lot. Lisa: Yes, yeah. Just one last question in relation to antioxidants, because I mean 10 years ago or so we used to think our reactive oxygen species ,oxidative stress happens through the electron transport chain. When we're metabolising, and so on, we get all these oxidative stresses and free radicals running around. And if we take antioxidants, we're going to be counterbalancing that. Does supplementing with antioxidants, like vitamin D, like glutathione, like vitamin C, and so on, alpha lipoic acid, is that going to contribute, too, to the slowing of aging, because it's going to down regulate the PARP enzymes? Dr Elena: People were very optimistic about antioxidants, something like 20 years ago. And everyone was talking about it and so on. But actually, the big studies that have been done, have shown that by taking antioxidants, you actually do not suppress aging. And there are some biomarkers that might have changed in those studies. But most of the biomarkers that they measure stay the same. Basically, saying that antioxidant is not the... Lisa: Not the holy grail. Dr Elena: ...that everyone was thinking about.  Lisa: Was hoping, yeah. Not to say that antioxidants don't have their place because they definitely do. Especially if you have a lot of oxidative stress, and you need to, like with vitamin C, if you're infected, or—I've done a whole series on vitamin C. But then it's not the holy grail for stopping the aging process, but it probably does help with not having so much PARP activation. I don't know, as a non-scientific brain, I'm just connecting dots.  Okay, so I think it's probably we've— so from a lifestyle intervention, apart from taking NMN and resveratrol, and oleic acid or olive oil, intermittent fasting, is there anything else that we can add to our anti-aging regime on a lifestyle intervention side?  Dr Elena: Intermittent fasting, and then avoid exposure to sunlight, as we said. And sirtuin genes are being activated from any kind of stress. And what we can do is we can also induce some sort of an artificial stress, which could be done, let's say with cryotherapy. This is what cryotherapy does. When you're exposed to cold, you also have this stress signal that activates sirtuins, or the other way around, so you can try out a sauna. And this will also have the same effect. So, I think this is also something to keep in mind.  Lisa: Breathing, breathing. So, sort of tumour breathing, or, like what one half does all of that sort of stuff. So, there’s hormetic stressors, there’s exercise obviously, that cause a cascade of changes and make you stronger. And yeah, it's sort of a balancing act. You don't want to be doing exercise for Africa or really freezing yourself to death, but you just want to have a little stress to cause a change in the body. So these hormetic stressors can be very, very helpful.  Okay, well, I think we've covered a very, very, very complex topic and I hope we didn't lose everybody on the way. But at the end of the day, take NMN, take resveratrol, take olive oil, do your exercise, get in the sauna, if you have a chance to do cold therapy, do that as well. Get your exercise, get your antioxidants in there as well, to a certain degree and you're going to be able to live long enough but until other things come online, and you'll be able to improve everything.  Dr Elena: Sounds good.  Lisa: Brilliant. So Dr. Elena, thank you very much. Dr. Elena has been on the show, NMN Bio. So we have nmnbio.co.uk in UK and in Europe, and nmnbio.nz if you're down at this end of the world. We'd love to help you over the air. If you've got any other questions, please reach out to us. And thanks very much for being here today. It's been really exciting. Dr Elena: Thank you, Lisa, thank you so much for having me. That's it this week for Pushing the Limits. Be sure to

Marta Pecina MD PhD. is Assistant Professor of Psychiatry, Director of the Translational Neuroscience and Neuroimaging Lab of the Department of Psychiatry and the UPMC Western Psychiatric Hospital. This Podcast focuses on the Neurobiological basis of placebo effects. Placebos have great power. We explain how both expectation and conditioning generate strong placebo effects relevant to research and their therapeutic use. Ethical issues about placebo use are furthermore addressed.

Dr. Yasmin Hurd is Professor of Psychiatry, Neuroscience and Pharmacology and Systems Therapeutics as well as the Ward-Coleman Chair in Translational Neuroscience at the Icahn School of Medicine in New York. She is also Director of the Center for Addictive Disorders in the Mount Sinai Behavioral Health System. Yasmin studies the brain and addiction. She wants to know how drugs impact the brain, as well as how genetics and other characteristics shape disease vulnerability. Her work also has applications for developing new therapeutic treatments for substance abuse. Outside of work, Yasmin loves cooking, including the challenge of assembling meals from the random ingredients in her pantry and hosting elaborate dinners for her friends. She has also developed a passion for painting. She received her PhD in Medical Science from the Karolinska Institute in Sweden and spent time as a Pharmacology Research Associate Fellow with the NIH and Staff Fellow at the National Institute of Mental Health. Afterward, Yasmin returned to the Karolinska Institute where she remained as a faculty member for 13 years before coming to Mount Sinai. She is also a member of the American Society for Neuroscience, New York Academy of Sciences, and the College on Problems of Drug Dependence. Yasmin shares more about her journey through life and science in this interview.

Aging is a gradual process of cell deterioration, but while it is a natural process, there are ways to hack its biological mechanisms. Certain supplements paired with sirtuin enzymes can lead to better well-being and suppress the effects of aging. In this episode, Dr Elena Seranova talks about the role of sirtuins in maintaining cell health. She also discusses how several supplements, including NMN and resveratrol, work to enhance the beneficial action of sirtuin. Listen to this episode to learn how to promote longevity and overall health.   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health program all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. You can also join their free live webinar on epigenetics.   Online Coaching for Runners Go to www.runninghotcoaching.com for our online run training coaching.   Consult with Me If you would like to work with me one to one on anything from your mindset, to head injuries,  to biohacking your health, to optimal performance or executive coaching, please book a consultation here: https://shop.lisatamati.com/collections/consultations   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within 3 years. Get your copy here: http://relentlessbook.lisatamati.com/ For my other two best-selling books Running Hot and Running to Extremes chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   My Jewellery Collection For my gorgeous and inspiring sports jewellery collection ‘Fierce’, go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Here are three reasons why you should listen to the full episode: Find out how sirtuins play essential roles in promoting longevity. Learn how NAD influences sirtuin activity and how several compounds can increase NAD levels in the body. Discover the best methods for taking resveratrol supplements.   Resources Dr Elena's study on stem cell models of neurodegeneration for studying autophagy Study on NAD supplementation by Dr Elena's collaborator Research paper on the benefits of trehalose by Lisa's supervisor   Episode Highlights [03:24] Elena's Background Originally a psychologist, Elena ventured into neuroscience through her work on a neurofeedback device for patients with psychological and neurological diseases. She eventually pursued a master's degree in translational neuroscience and joined a biotech startup. She continued her studies through a PhD focusing on the molecular pathways of autophagy. [09:41] Sirtuins and Gene Expression Sirtuins are enzymes arising from various genes found across multiple species. They play crucial roles in evolution. Sirtuins assist in epigenetic regulation, where different cells have different active genes. Events such as taking a sauna or engaging in exercise change the environment of your cells. Evoking changes in gene expression helps you adapt to these conditions. [19:09] Longevity Impacts of Sirtuins Sirtuin 1 is heavily involved in repairing DNA damage, while sirtuin 3 contributes towards mitochondrial health. The enzymes coming from both sirtuin genes require the molecule NAD for proper function. With insufficient NAD, sirtuin enzymes might be unable to fix DNA and mitochondrial damage sufficiently. [25:59] NAD Boosters NR and NMN are two promising energy booster supplements that might boost NAD+ levels. NMN shows higher bioavailability and more positive effects on aging mice. Elena herself experienced improved energy levels when she started taking NMN supplements during her PhD years. [37:05] Resveratrol and Sirtuins Resveratrol activates sirtuins, allowing them to function. It works well with NMN — resveratrol handles activation, while NMN provides energy. To increase the bioavailability of resveratrol, consume the supplement with dairy products or food items with oil. [40:01] Apigenin, Sirtuins and NADases Several enzymes compete with sirtuins for NAD. These NADases mean that sirtuins cannot function without a large NAD supply. Apigenin, which is present in parsley, blocks a certain NADase and leads to increased NAD levels.   7 Powerful Quotes from This Episode ‘We'll be having different sets of genes being activated, and this will be in response to different external stimuli, environmental stimuli, amino acids, even availability of nutrients’. ‘What sirtuins do is they upregulate many physiological processes in order to deal with potential danger’. ‘[Sirtuins] do need a molecule called NAD, nicotinamide adenine dinucleotide, and without this molecule, they cannot perform its functions. And what's happening when we age is unfortunately we do have reduced levels of this molecule as we age’. ‘From anecdotal evidence from myself and people that I know that have supplemented themselves with both, everyone just pretty much mentioned to me that they do like NMN much more than NR and they can see the effect and this is the reason why I ended up supplementing with NMN myself’. ‘So within three, four days, I actually felt a different “different”. I felt different energy levels, I felt an increase in my energy levels and I felt an increase in my focus’. ‘Basically what activates the sirtuins is the resveratrol molecule, but in order for them to function properly, you do need the NMN because this is what they consume in order to function, and so this is why it's such a good synergy’. ‘Besides sirtuins, there are different other enzymes called NADases that also consume NAD and if they do that consistently there is not enough NAD for sirtuins to do their job’.   About Dr Elena Dr Elena Seranova started her ventures into medicine through psychology. She established her private practice as a wellness centre, where she encountered neurofeedback therapy and decided to pursue neuroscience studies. She took up her MSc in Translational Neuroscience at the University of Sheffield, followed by a PhD in Stem Cell Biology & Autophagy at the University of Birmingham. Her work focuses on the molecular pathways involved in autophagy. Dr Elena is also a serial entrepreneur. Aside from her wellness centre, she also co-founded a biotech startup before her PhD studies. She is the founder of NMN Bio, a company focused on NMN and other anti-aging supplements. To learn more about Dr Elena and her work, reach out through her website.   Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can include more amino acids in protein in their diet. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa   Full Transcript of The Podcast! Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Well, hello everyone and welcome back to Pushing the Limits. Super excited to have you again with me. Today I have Dr Elena Seranova, who is a molecular biologist to guest on the show. And really exciting. We’re going to be having Dr Elena on regularly to talk different aspects of longevity and anti-aging. And today we're talking about longevity. We're talking about sirtuin genes. You might be thinking, ‘What the hell are sirtuin genes’? but you're about to find out. And why it's important and what you can do to upregulate and support these genes, these anti-aging genes or longevity genes.  So before we get over to the show, just want to remind you. If you are wanting help with any sort of health journey that you're on, if you want some one on one coaching and please reach out to me at lisa@lisatamati.com. If you're looking for help with gene testing, epigenetics, anything of that nature as we've spoken about before on this podcast, you can also reach out to me there, or check out the programme via our website, at lisatamati.com. Everything in health now is about personalizing everything to your genetics. So that's the nutrition, your timings of the day when you eat when you exercise, what parts of your brain you use the most, what your dominant hormones, your personality traits, because of your genetics, all of these aspects are covered in our epigenetics programme. So I'd love you to go and get that.  And for all you runners out there, come and join us at Running Hot Coaching, that's our online run training system. We'd love to coach you. We have personalized customized training plans specifically made for you for your specific goal, along with side video analysis, and you also get a one on one session with me. So go and check that all out at runninghotcoaching.com. That's all for data today.  I am really stoked to have you back. I hope that 2021 is going well for you, that you've had a good break over the last few weeks. And if you're in the southern hemisphere, you're enjoying our beautiful summer. So without further ado, Dr Elena Seranova over in Dubai.  Well, hi everyone and welcome back to Pushing The Limits. I'm super excited. I'm jumping out of my skin. I have an amazing lady with me, Dr Elena Seranova. Hello Dr Elena, how are you doing? Dr Elena Seranova: Hello, hello, it's really nice to be here today. Thank you for the invitation!  Lisa: It is super exciting. So Dr Elena is sitting in Dubai, and we're going to be having a really in depth conversation today. And it will get a little bit scientific but hang in there with us people because this is all about longevity and anti-aging and who isn't into that?  So Dr Elena is a molecular biologist. And she's going to be sharing today some really critical information about the sirtuin genes. you’d be going, ‘What the heck is a sirtuin genes and what do they do? And why do I need to know about them?’ But these are really important things.  But before we get into that, the nitty gritty of the science, Dr Elena, can you give us a little bit of background on you and where you've come from? And what you've done in a nutshell, so to speak?  Dr Elena: Absolutely, yes, so I'm actually an interdisciplinary scientist. So I started my studies in the field of psychology. And then I opened my private practice. So that was my first business that grew into a wellness centre and was in operation for five years. I had two branches. That was back in my home country in Greece.  And I ended up working with a neurofeedback device that was basically retraining the nervous system of different patients with psychological and neurological diseases. And this is how I got interested in neuroscience. And I started studying it myself. I took a couple of those online courses. And I realized that this is such an amazing field.  And in order to understand the symptoms that I see my patients, I actually need to understand the proper science behind it.  And when I started digging deeper, I realized that it's actually the genetic component that is the crucial part that produces all the symptoms. So then I found this amazing master's degree in neuroscience and genetics, and specifically in translational neuroscience in the UK. And back in the days, in 2015, the Greek crisis was bad. So I couldn't grow my business as much as I'd like.  So I decided to move to the UK to do this master's degree. And after this, I ended up, co-founded a biotech start-up that also had to do with the biochemical assays that were aimed at elucidating gene to gene regulatory networks.  And with that, I also realized that I'm even more fascinated by the science, and I really want to stay in biotech. And my co-founders were making fun of me because I was the only person in the office not having a PhD. Yes, that was a traumatic experience. And at the same time, they were surprised when I said that I'm leaving the start-up to do my PhD.  Lisa: They shouldn’t have said so.  Dr Elena: Yes, exactly. So yes, this is how I continued my studies. And my research was focused on the molecular pathway of autophagy. And I was using human physiological cellular platforms of neurodegeneration, utilizing human embryonic stem cells and induced pluripotent stem cells to model neurodegeneration, which was very, very interesting.  And I actually have a review in the Journal of molecular biology that got out a few months ago, in April 2020, on the modelling of neurodegenerative diseases and studying autophagy in those models in human pluripotent stem cells. For anyone interested, you can go check it out. It has an open access.  Lisa: We’ll put the link in. Well done. Congratulations, that’s pretty amazing. And that brings me to a point I'll have to have a separate conversation with you about neurodegeneration and what we can do for the elderly. I've got a vested interest in that one. So we'll definitely put that on our calendar because Dr Elena is going to be coming on the show actually quite regularly in the next few months. So we're going to be doing a bit of a series because I think the information that Dr Elena has is just going to be crucial for you guys out there listening. So really, really excited. But today's subject is all around sirtuin genes. Now these are—I'm going to try and explain it because I've been deep in this research too. So what tipped me down to this path and longevity and anti-aging, obviously, I've been in that space for a while. I listened to Dr David Sinclair on a podcast and subsequently read his book Lifespan, which I recommend everybody go out and buy. It's called Lifespan: How We Age—And Why We Don't Need To.  And Dr David Sinclair is a very, very prominent scientist at Harvard Medical School. And he has his own lab and he’s been studying anti-aging and longevity for decades now. And he was actually the one of the scientists who discovered resveratrol, which we're going to get into today and what resveratrol does, and it's very pertinent to the conversation. But it is also in this book, really giving me an eye opener into what's coming down the pipeline as far as longevity and being able to turn the clock, actually literally back to when you—so, our cells become young.  It sounds almost science fiction-y, some of the stuff that he's talking about that is just around the corner. It is like absolutely amazing stuff that we are going to be able to live longer, healthier lives. And for me, it is about health span, as well as like I obviously want to live long, but most importantly, I want to live healthy till the end. And I think that's probably the priority for everybody. Rather than having the typical degenerative, long, slow, drawn out process.  So anything that I can do to help my friends, my followers, my family live healthier lifespans, I'm into that research. So Doctor Sinclair is an expert on sirtuin genes, this is an area that he studied. And Dr Elena knows all about this. So Dr Elena, can you just tell us, for starters, where do we start on this big subject of longevity genes? And what they do in the body? That might be a good place to start.  Dr Elena: Yes, sure. So sirtuins are enzymes, basically. And it's a group of genes that is quite well conserved across multiple organisms, which means that they play a very important role in evolution and in our biology. And what they basically do is they control the epigenetic regulation in ourselves. And this means that when—in different tissues, there are different genes being activated at a different time. So we'll be having different sets of genes being activated, and this will be in response to different external stimuli, environmental stimuli, amino acids, even availability of nutrients, things like that. And what they really do is they control that all of the important regulatory pathways in the cell are functioning as needed, and they are quite responsive to external stimuli.  So for instance, you mentioned resveratrol, which is a molecule that is found in grapes and in other berries and different plant sources. So, resveratrol is actually found when the plants are stressed. So when there is some sort of either fungal infection in the plants, or there is no water and so on, resveratrol is the molecule that is being secreted. And what's happening is that sirtuins can sense this molecule, and as a result they do get upregulated.  And the reason for this — I guess this evolved from a revolutionary stand point of view is that, so you would have let's say, some small animals running around and consuming different plants, things like that. So the small animals cannot really distinguish consciously between danger, different dangers or lack of foods and things like that. So this process had to somehow be automated. So for this reason, again, resveratrol is like a signal that says to the little animal that there is some sort of danger in the environment. And then what's sirtuins do is they upregulate many physiological processes in order to deal with potential danger.  And there are different stimuli like that in our environment, and we can actually artificially activate sirtuins. So for example, with the use of sauna. We do have this heat shock response, where there is a stress signal from the environment, and then again sirtuins get activated because there is some sort of stressor coming into the body. Another one is exercise. So what happens? And actually not any kind of exercise. But let's say if you're just going for a walk for 20 minutes, you won’t get sirtuin activation. But if you're going for a run, and you start being out of breath, so that your body goes into slight hypoxia. And this is the signal that activates the sirtuin. So for all of the healthy living enthusiasts, don’t just go for a run. Absolutely.  Lisa: So just to recap on that, so this sirtuin genes which code for this enzyme. This enzyme is really important, and we'll get into a little bit more than nuts and bolts of this enzyme, but it does some very important activations on the genome, which is what we want.  Dr Elena: It basically regulates which genes will be switched on and which genes will be switched off. So it allows for a very tight control, for a very tight regulation of the functionality of different genes in the cell. Lisa: Right. And then so sauna, which produces heat shock proteins, I've just bought a sauna recently for that reason. Yes, yes. Well, I heard about heat shock proteins, what sauna can do, how beneficial it is for so many things. I didn't make the connection to that and sirtuin genes. So that's really something I've learned today.  I did know about the exercise, and this is why like high intensity interval training, in moderation people — not like go and do this every day, please, but in moderation. It has a longevity benefit, has an improved actual VO2 max and endurance. And all of these great cardiovascular benefits is partly in relation to the sirtuin genes.  And just going back to the resveratrol, this is a xenohormesis, isn't it? So a stressor that the body goes, ‘Oh, where our environment—is there's something wrong in our environment. So we need to hunker down and get ready for battle’, rather than going forth and multiplying and everything's easy and happy.  So we want to push and pull in regards to all of these things like exercise, like sauna, like resveratrol, you want times of actually pushing things and in times of recovery, so it's not just going in one direction, is it? It is like balance.  Dr Elena: Definitely. Definitely. And then yes. And then another trigger for the sirtuins phase, caloric restriction. And this again comes from what we just described about the animal being hungry, potentially in the near future. So the sirtuins get activated. So it’s the same when you're on a calorie restriction and you're doing intermittent fasting, you will get this reaction again.  And this is tied up to autophagy as well, which has been activated. So you actually need to be fasted for several hours for autophagy to be activated. And research suggests it could be around 18 to 20 hours or more in humans. So I'm personally trying to do this on a daily basis. I'm having a very narrow window where I consume food probably three, four hours a day. I mean, it's not possible, always, especially when you're traveling around like I do at the moment. It might be challenging because I also want to eat high quality food. So I don’t want to be eating junk at the airport. Lisa: Pretty hard, isn’t it?  Dr Elena: Yes. I mean, sometimes this actually pushes me to fasting even longer. Lisa: Great discipline. I can't—I struggle to go over the 16 hour. And I think partly with autophagy—so autophagy, people, this is when the body basically, there is a pathway called mTOR, which we're going to probably do another episode on. And this is a growth regulation pathway where we are actually—if we are activating there's a lot of amino acids, a lot of proteins in the body and a lot of nutrients in the body sort of goes into growth mode. So like bodybuilders want  this growth mode for example.  And when you go hypocaloric for a while and you restrict the calorie intake, then the body goes into a state of autophagy, which is where it's basically eating and recycling it's old cells that actually need to be gotten rid of. And these cells are called senescent cells. So these cells are alive, and they're putting out inflammatory chemicals or cytokines, and then not actually replicating, and that causes problems in the body. And as we get older, we eat more senescent cells.  So you don't want to be in a state of starving all the time. That's not what we're saying here. This is why it's intermittent fasting. And you don't have to do this every day, people. I know, I don't. I'm not as disciplined as Elena. But doing this on, I think something like five days may be normal and a couple of days, where it's sort of a longer fasting period. And just giving your body that change. If you go hypocaloric for weeks on end, you're going to down regulate your metabolism. So that's not where we want to go. And then you're going to have nutrient deficiencies and so on from that point of view. What we're trying to get is this seesaw, the body seems to—like in all of the studies that I've done, it seems to like the seesaw, like cycling. It likes going up and down, up and down. And that actually helps it keep its ideal balance, putting it very bluntly and simply.  So autophagy is something that we want. So fasting, mimicking sauna, exercise, all of these things are going to upregulate the sirtuin genes and these sirtuin genes. Now can you tell us—there are seven sirtuin genes in the human genome, can you just go briefly over what one up to seven does? Dr Elena: Yes, I mean, there are quite a few functions that those genes have. So I don't think we'll have time to go through all of them. The important ones for our subject today for sports and longevity, and so on, is sirtuin 1 for sure, which is a very important protein that can be found both in the nucleus and the cytoplasm. And actually, its expression is different in different kinds of tissues and it also depends on its necessity and its function. And it's actually what we’ve seen is that sirtuin 1 is one of the first genes that would go onto the side of a double stranded DNA break to recover it. So it is heavily involved with DNA repair, very important gene.  And then sirtuin 3 would be the other very important for longevity, which has to do with mitochondrial health and mitochondrial function. So those two, they both are enzymes that in order to function, they do need a molecule called NAD, nicotinamide adenine dinucleotide. And without this molecule, they cannot perform its functions. And what's happening, when we age is unfortunately we do have a reduced levels of this molecule as we age, of NAD. And it just keeps on decreasing and decreasing, basically leading into death but a literal death spiral, where you don't have this beneficial effect of the sirtuin genes repairing your genome, repairing your DNA. And the epigenetic regulation becomes basically loose. So this is what is directing the loss of cellular identity as well. So this is one of the hallmarks of aging, where the cells are losing their identity. And then everything that is happening in the cell, all of the functions, they’re being so tightly regulated. So this is what's happening there.  And then NAD, it's worth mentioning that it exists in two forms and both forms are important. So NAD+, which is the oxidized form and NADH, which is the reduced form. So the reduced form, it's actually something that not many people talk about in the aging space and the supplement space, so they barely know NADH and NAD+. And NADH is actually important for the maintenance of mitochondrial membrane potential. So if you don't have enough NADH, your mitochondrial membrane potential will not be preserved as needed. And this would also lead to decreased mitochondrial function. And decreased mitochondrial function means that you will have a less ATP production and less energy as a result.  And the reason why this is so important for neurodegeneration, as you mentioned previously, because actually, the central nervous system is perhaps the first one that is being affected as we age. So it's very important. And the reason for this is that the postmitotic neurons that we have in the brain, they are heavily relying on massive ATP production in order to function. Lisa: So let's stop there, Elena because your brain is so big. We might have lost a few people on the way there, we might have to backtrack a little bit. So NAD, nicotinamide adenine dinucleotide plus or NADH. So is this a little bit like oxidized, like vitamin C oxidizes and then reduces, oxidizes and reduces. And electrons can be donated backwards and forwards. Is that the same thing, sort of pathways?  Dr Elena: Yes, yes. Yes. That’s right. So NADH gains two electrons.  Lisa: And that is recycled through? Dr Elena: Yes, this is happening through electron transport chain in the mitochondria. And we need both of those molecules in order to maintain proper cellular function. And so this would bring us to our next subject, which is what we can do in order to fix this decline of NAD.   Lisa: Before we go there, let’s just hang on a tiny bit on this NAD, because — so NAD, I know Dr David Sinclair said, arguably the most important molecule. So people, note this name, NAD, NAD+, or NADH. This is the most important molecule in our body next to ATP, and ATP is our energy production. So without energy we’re dead in 30 seconds, and without NAD, we're dead in 30 seconds as well. So either or we're both pretty much up the creek if we don't have either. As we age, the NAD levels go down. And one of the things that regulates the NAD, or needs NAD sorry, is the sirtuin genes to do their job of DNA repair, is one of their jobs. There are many jobs that it does. And if the NAD is being used by the sirtuin genes to repair DNA, then it's not doing its other jobs. And as we get older, like we have something like 2 trillion DNA breaks, it can be wrong, per minute or something ridiculous. Dr Sinclair said, every minute in our body — so, these enzymes are running around trillions of times in our body doing the DNA repair. And also we need to replicate ourselves and do all of this sort of work.  So if the sirtuin enzymes are busy doing one thing, they're not doing another thing. So we want to have more of these enzymes available for all of these jobs. And especially as we get older, and we need more support. So that's just a bit of  how that sort of explained what the NAD is.  Now, we should go on to the next part of the equation. So like there was an NAD salvage pathway, the body needs grams of it every day and we don't necessarily just get it by our food. But there is NAD boosters. What can we do to increase our NAD levels in the body? Dr Elena: Yes, so yes, this is exactly where energy booster supplements come in. And there are various supplements out there. and recent evidence points towards two particular molecules that are being researched. One is an NR, nicotinamide riboside and then the second one is NMN, which is nicotinamide mononucleotide.  So now the NR molecule, in order to boost the NAD levels it needs to be converted into NMN first. And for this reason, scientists are focusing predominantly on NM. And I would say now there is increased interest in the NMN molecule at the moment because it looks like it has increased bioavailability, is being absorbed better. And in tests in mice, it does have a better effect on NR in terms of boosting NAD, but also in terms of the—in terms of improving the phenotype of aging mice with different studies that we've seen that have come out in the past couple of years, from gene expression to energy metabolism, lipid metabolism, insulin sensitivity. A bunch of other markers being improved in my supplemented with NMN. And I have to be honest with you I haven't looked in depth into the research for NR, however the evidence from NMN studies so far is quite overwhelming for me. Lisa: Exactly, wonderful with all the research, too.  Dr Elena: Yes. I mean we would need to have more comparisons but from anecdotal evidence from myself and people that I know that have supplemented themselves with both, everyone just pretty much mentions to me that they do like NMN much more than NR, and they can see the effect. And this is the reason why I ended up supplementing with NMN myself.  So basically, I started studying NAD biology in block during my PhD. And unfortunately, my research paper is not published yet, so I won't be able to share that out. Perhaps next year hopefully I'll be able to share my data with you.  There is a paper from our collaborators lab though that is on bio archive already. And it's from Viktor Korolchuk in Newcastle. And they showed there how basically functional autophagy can maintain NADH pools, which is quite an interesting paper. And it does intertwine a bit with my work. But unfortunately, I can't share right now.  Lisa: Yes, you have to keep zip right now until it's published. So we can link to the bio archive, the one you mentioned there, at least, do some research and also I’ll also link to Dr David Sinclair's work, in his book, obviously. Because it does put it in in a way that people can understand, which is really, really important.  Okay, so NMN, nicotinamide mononucleotide is one of the in NAD boosters, and we need the in NAD to... Dr Elena: Yes. And it's the only direct precursor of NAD. So this is the beauty of it. So from NMN, it converts straight away to NAD. So this is why it has such an enhanced bioavailability. This is why it has those effects because NAD is quite a large molecule by itself. So it's actually hard to—if you supplement orally with NAD. The absorption of the—it will not be high, because of how big the molecule is. So this is why it's called dinucleotide because it has two nucleotides that would need to penetrate the cell. But NMN is a mono nucleotide. And this is why it absorbs better Lisa: It's actually made there—it's put together in the cell. So the nicotinamide mononucleotide enters through the membrane into the cell, from what I'm understanding, and then it becomes a dinucleotide. So it's a phosphorus molecule, I think or something that's added to the NMN. And then it's an NAD.  Dr Elena: So yes, so basically it's NMN is a phosphorylated NR molecule basically.  Lisa: Okay, phosphorylated NR molecule, okay, and then when it goes to NAD... Dr Elena: And that’s the reason why NMN is actually a bit more expensive than other supplements. Because in comparison to other supplements that are just, let's say, plant extracts or something like this, there is quite a lot of biology implicated in the production of NMN. So there are several steps it would need to go through. And it's quite complex and laborious to produce. And this is why it's a bit higher in terms of price.  But from my personal experience again, so I started supplementing with NMN over a year ago, while I was still doing my PhD. And at that point—when I found NMN, I already had a burnout. So, which is something that a lot of PhD students experience and my project was quite, quite challenging. And human embryonic stem cells require quite a lot of cell culture in order to just survive, let alone to expand them and do experiments on them.  So yes, at some point during my PhD, I literally was doing 18 hours, from 6am till midnight. With eight or ten hours of cell culture during that day, let alone the experiments I had to do. So yes, quite challenging. However, it was a priceless experience. I learned a lot. And I think that it was definitely worth it.  So yes, back in the day, so while I was experiencing this burnout, I found out about NMN. And I thought to give it a go. And it was basically amazing the fact because I've been supplementing with different supplements for the past 15 years or so. And I'm a biohacker myself.  Lisa: Yes, yes. Like me. Dr Elena: I transfer with different supplements and stuff. And this was the supplement that I felt the effect of within a few days of taking it and I've never experienced that before with any other supplements. So within three, four days, I actually felt different. I felt the different energy levels. I felt an increase in my energy levels and I felt an increase in my focus. And I remember my partner calling me at some point in the evening at 8 or 9pm, something like that. And we were talking on the phone and he just said ‘Oh, so you're not tired yet’. And I’m like, ‘No, I'm not tired. I actually feel great’. Lisa: ‘This stuff's working’. Dr Elena: Absolutely. Yes. And this is how my current business was born. And this is how NMN Bio was born. And I was so excited to actually have a product in the market that is pure, potent and I know that it is what it is. And because I have been struggling to find a good supplier of NMN for quite some time.  Lisa: Tell me about it.  Dr Elena: Yes, because of its price, I think that there are quite a lot of opportunistic companies out there that just white label the NMN powder, and they don't even have a certificate of analysis and you don't even know what's in there and things like that. And they just totally diluted with niacin or something else. Lisa: Exactly. Yes, this is a danger and this is why having a significant analysis and having it scientifically backed in every batch tested and stuff is really important. I've been on—prior to meeting Dr Elena—I've been on in NMN for maybe five, six months now. And I've had my mom and my brother on it and my husband on it. But I had to go through, jump through all of these loops to get it out of America. Get it sent to someone there. Get it shipped over here and it's not been available down the scene of the world. And finding a reputable source is absolutely key with this molecule.  I remember David Sinclair saying, when you do get your NMN do keep it in a cool, dry place. So don't stick it in a hot place under the sun somewhere. Ideally, probably in the fridge if you can, to give it an extended shelf life and for it to do its job properly.  So you've founded a company NMN Bio, at the UK, and I'm really excited to be working with Dr Elena and I'm going to be importing it down to Australasia. Dr Elena: I'm super excited about this too. Lisa: Yes, me too. Like it's just super exciting for me. Because I'm spending a fortune a month, giving this to my family anyway. And I could never test what I was doing. And now I have a place where I can trust that it's coming from a good source.  So nicotinamide mononucleotide is the one aspect but that's not the end of it all. Is it though? That's not—so resveratrol we mentioned before. This work in combination—and on that point, it should be trans-resveratrol that you take, if you're taking resveratrol with it. Dr Elena: Yes, absolutely. Lisa: And we don't have this yet in the cater of products. But this is in the pipeline, isn't it, Dr Elena?  Dr Elena: Absolutely. Yes, this is coming in 2021. Super excited about it. Hopefully we'll have it on the market in the next few months. Lisa: In the next months.  And but resveratrol, trans-resveratrol you want to be taking that in combination with nicotinamide mononucleotide. So an analogy that Dr Sinclair said was resveratrol is like the accelerator pedal and nicotinamide is the fuel. I think that’s the way around.  Dr Elena: Yes, absolutely. That's correct, because basically what activates the sirtuin is the resveratrol molecule. But in order for them to function properly, you do need the NMN because this is what they consume in order to function. And so this is why it's such a good synergy. And as you said, trans-resveratrol is absorbed much more. And also in order to increase the bioavailability of resveratrol, it's good to take it with some sort of full fat dairy. So for instance, a yogurt. David Sinclair says that he does take it in the morning with a full fat yogurt. Lisa: With some fat, yes.. Dr Elena: In fats, or you could you could do some cheese, probably. I do yogurt as well.  Lisa: Does it have to be dairy? I've been taking it with oil, is that okay?  Dr Elena: Yes, this could work as well. So yes, absolutely. There are a few people doing olive oil for this type. Lisa: So it just needs a fat in order for it to be bioavailable, because it’s a dry powder. And so the oil in the fat helps. Because it's a very insoluble molecule. Dr Elena: And then what I do for my personal anti-aging cocktail... Lisa: Which is obviously working, because Dr Elena is actually 110 years old.  Dr Elena: No, just 32.  Lisa: She’s just 32 but looks like—honestly, I thought, seriously 32? I would have thought you were 22. So something's working. The good diet. It can't be that overworked because you've been definitely overworking for the past few years. And this is obviously helping.  And I'm 52. So I'm old enough to be your mom. And I'm definitely super excited about anything that's coming down the pathway that's going to slow down the degeneration. Because over the years, and after smashing the crap out of my body, I've definitely got some repair work to do. And my mom is 79 years old, she's in the corner over there, taking her NMN as we speak, and her resveratrol, along with their hemp seed oil and all the other supplements and a big green smoothie of broccoli juice. So she's like going, ‘ugh’, it'd be quite funny for you to see her face right now.  Dr Elena: You should also add apigenin to her cocktails. So, this is another molecule which is very interesting. And perhaps in a later podcast, we can also talk about a couple of different things that have to do with raising your NAD levels in different ways. So, basically, what happens, besides sirtuins, there are different other enzymes called NADases that also consume NAD. And if they do that, consistently, there is not enough NAD for sirtuins to do their job. So such enzymes are called parks, which are activated when there are some stress signals in the body. So, for instance, one such signals when let's say your mitochondria are going bad and there is some sort of stress related to mitochondrial function, you will get a secretion of cytochrome c from mitochondria. And then as a result, you will get some sort of activation of the park enzymes and they also consume NAD. Another NADase is CD38. So, this is an enzyme that is activated when there is increased inflammation in the body. So, as we age, CD38 levels increase. And what has been demonstrated very beautifully in a recent study in mice was that CD38 actually controls the functions of sirtuin 3 in an NAD dependent manner. Because they did quite an elegant experiment, where they did have CD38 knockout mice, and the wild type mice or regular mice. And in the CD38 knockout mice the levels of sirtuin are two and a half times higher. And then when they put a saturating amount of NAD in the wild type mice, what happened is basically the function of sirtuin is also increased. And it was similar with the function of surgeries in CD38 knockout mice. So this means that if CD38 is absent, then sirtuin3 in this instance is upregulated and is working much more. But when CD38 is present, it consumes all of NAD and then there is not enough NAD for sirtuins.  Lisa: And this is so this is why we need a bigger pool of NAD, basically for all of these problems as we age.  Dr Elena: So this is one point and then the second point I was going to do there is that apigenin, so the supplement that I mentioned to you, which is actually present in parsley and predominantly in dried parsley. So you can actually get it for cheap.  Lisa: Yes.  Dr Elena: Have a teaspoon of dried parsley every day. So apigenin is a molecule that actually blocks CD38. So this means that it can also increase the levels of your NAD and make it available for your sirtuins. Lisa: Wow. I'm off to get some parsley. I just ripped my parsley plants out of the garden. Bugger. I will get seeds, so I'll have to plant some more. And you do need to dry it in order for it to intensify. Dr Elena: If you dry it, it will have even apigenin. So, the bioavailability increases somehow, I'm not entirely sure of the mechanism. But yes, dried parsley.  Lisa: Yes. Sorry. There's a noise in the background with my mum washing out a broccoli. Dr Elena: No worries. Lisa: Yes, yes, yes, this is my podcast life. Real.  So activated immune cells. So like I've had an infection for the last couple of weeks. So I've been under a hell of a lot of stress in the last year, like really—losing my father and so on, a hell of a lot of stress. And the day before Christmas, I stopped working and I started to relax and my immune system then went, ‘Okay, cortisol levels are now going down. We're going to make you sick. We’re going to do some repair work’.  Dr Elena: That’s how it’s usually done.  Lisa: Yes, yes. That's what happens when you relax. So my whole Christmas period was spent with a head cold and a chest cold. Now, when my immune system is activated like that, I'm going to need a lot more NAD because of this in NADases. You call them, NADases? And the CD38 would have been one of those things that was probably more active when I was sick. Would that be right? Okay, so we need to increase that in order to help our immune system.  So does this—random thought—does this help with other autoimmune diseases as well? Like, does it help deep down regulate some of the inflammatory pathways?  Dr Elena: I don't know, this is not my area of expertise. Wouldn’t be able to comment on top of my head on this. Lisa: Yes, just me connecting the dots going—that would make sense but okay. So all right, so we've covered quite a lot of ground today. And I think we'll probably wrap it up there, Dr Elena. And we'll go on to mTOR and autophagy and other things in subsequent podcasts, and so on.  So we're going to put all the links. If you guys want to get some NMN, and in a few months, we will have resveratrol as well. I'm going to put the links in the show notes to the new website. And we're going to be importing it down to here to New Zealand and Australasia. And I'm really excited about that. Because there is one other company that has it here and it's not got any certificate of analysis, there's no sort of thing. So you want to make sure that you know where you're getting this information from all your supplements from, and you want to know who's behind it.  So I'm really, really excited about working with your Dr Elena. I think this is brilliant. I know we've got a whole lot of products that are in the pipeline that are going to be coming down in the next year or so. Other things—so we will be covering those in future episodes. Things like, I don't know epistane...  Dr Elena: We should definitely talk about senescent cells and what we can do in order to combat them. And then of course, the subject of my PhD, which was around autophagy. So, this is definitely a very nice subject for discussion, because as you mentioned, mTOR is not something that you want to mess with on a regular basis. And actually, the good news are that there is the mTOR- dependent activation of autophagy and mTOR independent activation of autophagy. So my PhD supervisor was the one that discovered during his PhD probably 20 years ago, 15 years ago, the mTOR- independent regulation of autophagy and different molecules that value also can work and activate autophagy in an mTOR-independent manner. So one such molecule is already on the market as a natural sweetener. It's called trehalose.  Lisa: Trehalose.  Dr Elena: If you want to supplement your... Lisa: How do you spell that?  Dr Elena: Trehalose. T-R-E-H-A-L-O-S-E. This is what I use for my coffee. Lisa: Oh, trehalose. So that will help you increase your autophagy?  Dr Elena: Trehalose has been shown to activate autophagy in an mTOR-independent manner. Yes. Lisa: Wow. So I don't need to starve myself in order to activate...  Dr Elena: I mean, there is not that much data in humans yet on this particular molecule, to be honest. I actually don't know what is the dose that you would need to have this effect, but I still prefer it over sugar. Lisa: Yes, absolutely. And anything that supports that pathway anyway and getting rid of these senescent cells. So senescent cells just for those wondering what the hell we're talking about. Senescent cells are basically cells that are still alive, but they're no longer replicating. They're not doing the job properly. And they're sending out inflammatory signals into the body. So they attract cytokines that cause inflammatory responses.  And so what we want to do is we want to knock these cells off them to have their autophagy, meaning their cell death. And when we recycle the parts of the cells for the new job, and that's what we want to happen. As we get older, we get more and more senescent cells and there's actually literally ways our body down and stops and increases inflammation and causes a lot of the effects of aging, if you like. So that's definitely a subject for next time. But Dr Elena, you've been fabulous today. Thank you so much for the work you do, for the patient you bring to the project. I'm super excited about our collaboration and helping lots of people stay younger for longer. I think that will be. Dr Elena: Absolutely, that’s the goal. Lisa: Yes, absolutely. Have a wonderful evening because it’s around midnight in Dubai. So thank you very much for staying up late for me over in Dubai. It's probably too much.  Dr Elena: My pleasure. Lisa: And we'll see you again soon. Thanks Dr Elena. Dr Elena: Okay, thank you. Bye bye. That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends. And head over and visit Lisa and her team at lisatamati.com.

Join us for a discussion on the RAPID-EC Study that's shaping the national conversation about the pandemic's effects!  The Rapid Assessment of Pandemic Impact on Development - Early Childhood Study (RAPID-EC) is an ongoing survey of nationally representative households with children ages 0-5 that gathers essential information on the needs, health promoting behaviors, and well-being of children and their families during this COVID-19 pandemic. These results can provide actionable data to key stakeholders to inform immediate and long-term policy decisions. We will hear from RAPID-EC Project Director, Dr. Phil Fisher, and renowned Policy Advisor and Scholar, Dr. Joan Lombardi.  Dr. Philip Fisher is the Philip H. Knight Chair and Professor of Psychology at the University of Oregon, where he serves as Founding Director of the Center for Translational Neuroscience. He is also a Senior Fellow at the Center on the Developing Child and a member of the National Scientific Council on the Developing Child, both based at Harvard University. Philip's research focuses on developing and evaluating early childhood interventions in socially and economically marginalized communities. Dr. Joan Lombardi is a Senior Scholar at the Center for Child and Human Development at Georgetown University, focusing on global child development issues. She has been a policy advisor to organizations such as UNICEF, WHO, The World Bank and countless others. She also served as the first Deputy Assistant Secretary for Early Childhood during the Obama Administration 2009-2011, and as the first Director of Child Care and the Deputy Assistant Secretary for Policy and External Affairs in the Administration for Children and Families during the Clinton Administration (l993-98).

Contentgroup CEO David Pembroke learns everything you need to know about the brain and how to train the brain from Professor Bartlett. Founder and CEO of contentgroup. Adviser to Eddie Jones, Head coach, England Rugby teamDavid and Anna Pembroke knew that Australians value content and that is the best way to reach them.Today, they lead a team of highly-regarded veterans and digital-savvy creatives who are experts in multimedia communication, specialising in helping government and the public sector engage with citizens.contentgroup’s skills and knowledge in media, marketing, public relations, politics and private industry set us apart. We are used to working in environments where the pace of change is fast and the challenges significant.While our head office is in the heart of the National Capital, we are also connected to communities across the country through a network of clever consultants and suppliers.From Federal Government departments and agencies to Local Government councils, we have a track record for delivering best practice strategic communication and stakeholder engagement services, backed by quality content, advice and training.That is contentgroup’s ‘swim lane’ and we are proud to be recognised as industry leaders – who are also easy to work with!In addition to her aforementioned role, Professor Bartlett is a Group Leader in Translational Neuroscience and has been awarded the Lawrie Austin Award for her contributions to Neuroscience by the Australian Neuroscience Society in 2019.Professor Bartlett is also the CEO and Founder of MiGFiT Inc, a start-up company spun out her research lab that is focused on brain training for resilience, fitness and to reduce addiction and obesity.She has won the Outstanding Achievement Award and the Biotech Research Award and was an Ambassador for the Women in Technology organisation. Professor Bartlett recently launched three books to raise awareness about the brain health and to make neuroscience neuroplasticity actionable. Additionally, she has presented a TEDx talk about the brain fitness and neuroplasticity revolution underway focused on neuroplasticity for brain health.Discussed in this episode:The evolution of the brain and how it affects us nowHow you can train your brainPrevention vs Treatment to improve mental healthMental health in the workplaceDoomscrollingSupport the show (https://www.patreon.com/selenab)

This week on GovComms, we speak with Professor Selena Bartlett who is a Research Capacity Building Professor in the School of Clinical Sciences, Faculty of Health at the Queensland University of Technology. Contentgroup CEO David Pembroke learns everything you need to know about the brain and how to train the brain from Professor Bartlett. In addition to her aforementioned role, Professor Bartlett is a Group Leader in Translational Neuroscience and has been awarded the Lawrie Austin Award for her contributions to Neuroscience by the Australian Neuroscience Society in 2019. Professor Bartlett is also the CEO and Founder of MiGFiT Inc, a start-up company spun out her research lab that is focused on brain training for resilience, fitness and to reduce addiction and obesity. She has won the Outstanding Achievement Award and the Biotech Research Award and was an Ambassador for the Women in Technology organisation. Professor Bartlett recently launched three books to raise awareness about the brain health and to make neuroscience neuroplasticity actionable. Additionally, she has presented a TEDx talk about the brain fitness and neuroplasticity revolution underway focused on neuroplasticity for brain health. Discussed in this episode: The evolution of the brain and how it affects us now How you can train your brain Prevention vs Treatment to improve mental health Mental health in the workplace Doomscrolling Hosted on Acast. See acast.com/privacy for more information.

This week on GovComms, we speak with Professor Selena Bartlett who is a Research Capacity Building Professor in the School of Clinical Sciences, Faculty of Health at the Queensland University of Technology. Contentgroup CEO David Pembroke learns everything you need to know about the brain and how to train the brain from Professor Bartlett. In addition to her aforementioned role, Professor Bartlett is a Group Leader in Translational Neuroscience and has been awarded the Lawrie Austin Award for her contributions to Neuroscience by the Australian Neuroscience Society in 2019. Professor Bartlett is also the CEO and Founder of MiGFiT Inc, a start-up company spun out her research lab that is focused on brain training for resilience, fitness and to reduce addiction and obesity. She has won the Outstanding Achievement Award and the Biotech Research Award and was an Ambassador for the Women in Technology organisation. Professor Bartlett recently launched three books to raise awareness about the brain health and to make neuroscience neuroplasticity actionable. Additionally, she has presented a TEDx talk about the brain fitness and neuroplasticity revolution underway focused on neuroplasticity for brain health. Discussed in this episode: The evolution of the brain and how it affects us now How you can train your brain Prevention vs Treatment to improve mental health Mental health in the workplace Doomscrolling

Tune in to The College Neuro Network's first Yale episode where we chat with Dr. John Krystal, Jr. Professor of Translational Research and Professor of Psychiatry and Neuroscience at Yale University, Co-Director of the Yale Center for Clinical Investigation, Chairman of the Department of Psychiatry, and the Director of the NIAAA Center for Translational Neuroscience of Alcoholism at the Yale School of Medicine. The College Neuro Network seeks to gain insight into the neuroscience department and opportunities at the most prestigious universities in the nation by talking with both undergraduate students as well as professors of neuroscience. In today's episode, learn about neuroscience at Yale directly from an inspirational professor! Episode Hosts and Editors: Sasha Tunsiricharoengul and Sarah Mirsaidi

Dr. John Krystal is the Chair of the Department of Psychiatry and the Robert L. McNeil, Jr Professor of Translational Research at the Yale University School of Medicine. He received his BA in behavioral sciences at the University of Chicago. He received his MD and completed his residency at Yale. He is the Chief of Psychiatry at Yale-New Haven Hospital. He is the Director of the NIAAA Center for the Translational Neuroscience of Alcoholism and the Clinical Neuroscience Division of he VA National Center for PTSD. Some of his awards include the ACNP Joel Elle's Award, the Anna-Monika Foundation Depression Research Prize, and the Paul Hoch Research Award among others. He has published over 500 papers and reviews on schizophrenia, alcoholism, PTSD, and depression. Dr. Krystal and his colleagues discovered a new treatment for depression named Spravato, an esketamine drug that modulates the neurotransmitter glutamate. Tune in for our in depth discussion on clinical depression.

What is "serve and return"? What does it mean to have a "responsive relationship" with a child? How do responsive relationships support healthy brain development? And what can parents and caregivers do in their day-to-day lives to build these sorts of relationships? This episode of The Brain Architects podcast addresses all these questions and more! Contents Podcast Panelists Additional Resources Transcript Fortunately, there are many quick, easy, and free ways to create responsive relationships with children of any age. To kick off this episode, Center Director Dr. Jack Shonkoff describes the science behind how these interactions—known as "serve and return"—work. This is followed by a discussion among a panel of scientists and practitioners including Dr. Phil Fisher, the Philip H. Knight Chair and Professor of Psychology at the University of Oregon, and director of the Center for Translational Neuroscience; Patricia Marinho, founder and CEO of Tempojunto and co-founder of Programa BEM; and Sarah Ryan, director of Life Skills at Julie's Family Learning Program. The panelists discuss what it looks like to serve and return with children on a daily basis, and how to encourage these interactions. Panelists Dr. Phil Fisher Patricia Marinho Sarah Ryan Additional Resources Resources from the Center on the Developing Child Working Paper 1: Young Children Develop in an Environment of Relationships Serve & Return Interaction Shapes Brain Circuitry 5 Steps for Brain-Building Serve and Return How-to Video: 5 Steps for Brain-Building Serve and Return Play in Early Childhood: The Role of Play in Any Setting Building Babies' Brains Through Play: Mini Parenting Master Class FIND: Filming Interactions to Nurture Development Articles Beecher, Michael D. & Burt, John M. (2004). The role of social interaction in bird song learning. Current Directions in Psychological Science, 13(6), 224-228. Kok, R., Thijssen, S., Bakermans-Kranenburg, M. et al. (2015). Normal variation in early parental sensitivity predicts child structural brain development. Journal of the American Academy of Child and Adolescent Psychiatry, 54(10), 824–831. Kuhl, P.K., Ramírez, R.R., Bosseler, A., Lin, J.L. & Imada, T. (2014). Infants' brain responses to speech suggest analysis by synthesis. Proceedings of the National Academy of Sciences. 111(31), 11238-11245. Levy, J., Goldstein, A. & Feldman, R. (2019). The neural development of empathy is sensitive to caregiving and early trauma. Nature Communications, 10, 1905. Marler, Peter (1970). Birdsong and speech development: Could there be parallels?. American Scientist, 58(6), 669-673. Ramírez-Esparza, N., García-Sierra, A. & Kuhl, P.K. (2014). Look who's talking: Speech style and social context in language input to infants is linked to concurrent and future speech development. In press: Developmental Science, 17(6), 880-91. Rifkin-Graboi, A., Kong, L., Sim, L.W. et al. (2015). Maternal sensitivity, infant limbic structure volume and functional connectivity: A preliminary study. Translational Psychiatry, 5, e668. Romeo, R.R., Leonard, J.A., Robinson, S.T., et al. (2018). Beyond the 30-million-word gap: Children's conversational exposure is associated with language-related brain function. Psychological Science, 29(5), 700-710. Sethna, V., Pote, I., Wang, S. et al. (2017). Mother–infant interactions and regional brain volumes in infancy: An MRI study. Brain Structure and Function, 222, 2379–2388. Yu, C. & Smith, L.B. (2013). Joint attention without gaze following: Human infants and their parents coordinate visual attention to objects through eye-hand coordination. PLoS One, 8(11), e79659. Resources from Our Panelists Dr. Phil Fisher The FIND Program Patricia Marinho Tempojunto (in Portuguese) Progama BEM (video in Portuguese with English subtitles) Transcript Sally: Welcome to The Brain Architects,

Dr. Vincent P. Clark is an expert in Neuropsychology.  With an interest in brain stimulation for neuroenhancement and brain stimulation for the treatment of chronic pain, addiction, schizophrenia, Parkinson's disease, and motor illness, Dr. Clark and his team are making a real difference in the way that we use science to heal.  Join us as we explore thoughts and ideas of how to harness the power of our brains with this week’s scientist. Show Notes Dr. Vincent P. Clark, Professor of Translational Neuroscience, has worked with the Mind Research Network (MRN) as Director of Neuroscience, then as Scientific Director recruiting scientists and helping MRN to increase its grant portfolio by expanding into new areas of research such as addiction, accelerated learning, and multimodal imaging.  In association with the Department of Psychology at the University of New Mexico where he is Founding Director of the new Clinical Neuroscience Center, he and his associates investigate the relationship between mind and brain. Mind Research Network Dr. Vincent Clark 2019 BrainSTIM Meeting   Contact: vclark@mrn.org vclark@unm.edu brainstimunm@gmail.com) – also use for volunteers for research studies

Dr. Vincent P. Clark is an expert in Neuropsychology.  With an interest in brain stimulation for neuroenhancement and brain stimulation for the treatment of chronic pain, addiction, schizophrenia, Parkinson's disease, and motor illness, Dr. Clark and his team are making a real difference in the way that we use science to heal.  Join us as we explore thoughts and ideas of how to harness the power of our brains with this week’s scientist. Show Notes Dr. Vincent P. Clark, Professor of Translational Neuroscience, has worked with the Mind Research Network (MRN) as Director of Neuroscience, then as Scientific Director recruiting scientists and helping MRN to increase its grant portfolio by expanding into new areas of research such as addiction, accelerated learning, and multimodal imaging.  In association with the Department of Psychology at the University of New Mexico where he is Founding Director of the new Clinical Neuroscience Center, he and his associates investigate the relationship between mind and brain. Mind Research Network Dr. Vincent Clark 2019 BrainSTIM Meeting   Contact: vclark@mrn.org vclark@unm.edu brainstimunm@gmail.com) – also use for volunteers for research studies

No. Seriously. What IS translational neuroscience? Dr Leighton Hinkley, PhD at the University of California, San Francisco talks with Austin about the last "black box" of the medical sciences - the brain. Dr Hinley's brand of neuroscience is a fascinating blend of artistry and hard science. It's really illuminating. And of course - brrrrraaaaaiiiiiiiinnnnnnnnnnssssss... Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

In this episode we talk with Dr. Edgar Garcia-Rill, Director of the Center for Translational Neuroscience, a Professor of Neurobiology and Developmental Sciences, and Professor of Psychiatry at the University of Arkansas for Medical Sciences, about why we sleep, the stages of sleep, disorders that can manifest due to poor quality of sleep and much more

Whilst at the Alzheimer’s Society Annual Conference (22–23 May, London, UK), we had the pleasure of speaking to Simon Lovestone, a Professor of Translational Neuroscience at the University of Oxford (UK), to hear more about his talk on ‘Dementia – Big problem; Big Data – Big solution?’ In this #NCTalks podcast recorded at the event, Sharon Salt (Editor) speaks to Simon to find out more about big data in dementia, including an overview of the talk given and how scientists can do more big data research. Listen to our podcast below to find out more. View more podcasts, news and exclusive interviews at www.neuro-central.com

Dr. Mark Yarborough, Dean's Professor of Bioethics from UC Davis, joins us to talk about the bioethics of clinical trials--the question of whether new practices in biological research are both moral and ethical. This topic has a huge impact on research currently being done on Huntington's disease. He'll also talk about the challenges of doing clinical trials for Juvenile Huntington's disease. IRBs (Institutional Review Boards) make decisions about whether proposed clinical trials are ethical and whether enough research has been done to minimize the risk to human participants. They also determine whether potential benefits outweigh the risks and help determine the informed consent process for clinical trials. The ultimate goal is to make sure that science is done the "right" way. Mark recently helped plan and co-hosted Herrenhausen Conference: “Lost in the Maze? Navigating Evidence and Ethics in Translational Neuroscience”, February 14 – 16, 2018, Herrenhausen Palace, Hanover, Germany.

My guest today, Dr. Eliott Berkman, is a tenured Associate Professor of Psychology at the University of Oregon, where he directs the Social and Effective Neuroscience Laboratory and conducts field-leading, federally-funded research on goals, motivation, and behavior change. He's also the Associate Director of the Center for Translational Neuroscience, and an author who writes about psychology and neuroscience for lay audiences, including in Psychology Today. We talk about the concept of the will and the way of goal pursuing, where the way is the set of cognitive skills, capacities, and ability that we collectively call the executive function, and the will is the motivational factors that propel the behavior. We also talk about how to increase our motivation and influence other people's behavior, the idea of flow states, and how that applies to achieving goals.

Watch as Alejandro uses volunteers from the audience to help describe his research into Motor Neurone Disease (MND/ALS).

Dr. David Beversdorf is an Associate Professor of Radiology, Neurology, and Psychological Sciences and holds the William and Nancy Thompson Chair of Radiology at the University of Missouri. In addition, David is the Director of the Cognitive Neuroscience Laboratory at the MU Thompson Center, Director of the Center for Translational Neuroscience and Director of Graduate Studies for the Interdisciplinary Neuroscience Program there. He received his M.D. from Indiana University School of Medicine and completed a Neurology residency at Dartmouth. David then completed a fellowship in Behavioral Neurology at the University of Florida and served on the faculty at Ohio State University before joining the faculty at the University of Missouri where he is today. David is here with us today to tell us all about his journey through life and science.

Nuffield Department of Clinical Neurosciences Seminar

Kathryn interviews neuroscientist Dr. Frances E. Jensen, author of the book “The Teenage Brain: A Neuroscientist's Survival Guide to Raising Adolescents and Young Adults”. Dr. Jensen discusses how aspects of the teenage brain – from learning and memory to gender differences – are changed once a person experiences a head trauma. Dr. Jensen is Chair of the Department of Neurology at the University of Pennsylvania and was Director of Translational Neuroscience at Harvard Medical School. Kathryn also interviews breast cancer survivor Stephanie Hosford about her book “Bald, Fat & Crazy: How I Beat Cancer While Pregnant with One Daughter and Adopting Another”. Having a baby is a monumental experience, and so is adopting a child; being diagnosed with cancer comes with its own emotional and physical entanglements. Now, imagine what it would be like to experience all three at once. “Bald, Fat & Crazy” is Hosford's heartfelt and humorous memoir chronicling her unique circumstances.

Kathryn interviews neuroscientist Dr. Frances E. Jensen, author of the book “The Teenage Brain: A Neuroscientist's Survival Guide to Raising Adolescents and Young Adults”. Dr. Jensen discusses how aspects of the teenage brain – from learning and memory to gender differences – are changed once a person experiences a head trauma. Dr. Jensen is Chair of the Department of Neurology at the University of Pennsylvania and was Director of Translational Neuroscience at Harvard Medical School. Kathryn also interviews breast cancer survivor Stephanie Hosford about her book “Bald, Fat & Crazy: How I Beat Cancer While Pregnant with One Daughter and Adopting Another”. Having a baby is a monumental experience, and so is adopting a child; being diagnosed with cancer comes with its own emotional and physical entanglements. Now, imagine what it would be like to experience all three at once. “Bald, Fat & Crazy” is Hosford's heartfelt and humorous memoir chronicling her unique circumstances.

Dr. Yasmin Hurd is Professor of Psychiatry, Neuroscience and Pharmacology and Systems Therapeutics as well as the Ward-Coleman Chair in Translational Neuroscience at the Icahn School of Medicine in New York. She is also Director of the Center for Addictive Disorders in the Mount Sinai Behavioral Health System. She received her PhD in Medical Science from the Karolinska Institute in Sweden and spent time as a Pharmacology Research Associate Fellow with the NIH and Staff Fellow at the National Institute of Mental Health. Afterward, Yasmin returned to the Karolinska Institute where she remained as a faculty member for 13 years before coming to Mount Sinai. She is also a member of the American Society for Neuroscience, New York Academy of Sciences, and the College on Problems of Drug Dependence. Yasmin is with us today to tell us all about her journey through life and science.

Mimoun Azzouz, Professor of Translational Neuroscience, discusses and demonstrates the gene-based therapy for Motor Neurone Disease (MND) being carried out at the Institute.

Professor Malcolm Macleod Personal, Chair in Neurology and Translational Neuroscience, delivers his inaugural lecture entitled, "Rigour Mortis: How Bad Research is Killing Science".Recorded on 26 May 2014 at the University of Edinburgh's Chancellor's Building.

We're seeing definitive moves toward the legalization of marijuana for recreational use. As the use of pot becomes normalized, what will be the impact on teens and what should parents say to their teens about its use. Follow: @rrlamourelle @bamradionetwork Yasmin Hurd is the Director MD/PhD Program, Professor in Psychiatry, Neuroscience and Pharmacology and Systems Therapeutics at the Friedman Brain Institute at the Icahn School of medicine. Dr. Matthew Smith has a Ph.D. in Social Work with Post-Doctoral Training in Psychiatric Epidemiology and Translational Neuroscience. His research interests cover the influence of alcohol and illicit substances on brain anatomy.

What do we mean when we say we "put our mind inside our body" when we meditate, do qigong, or Tai Chi? Dr. Cathy Kerr helps us understand this question from the perspective of modern neuroscience. In addition to being a Tai Chi practitioner, Cathy is the Director of Translational Neuroscience at Contemplative Studies Initiative and an Assistant Professor in the Department of Family Medicine at Brown University. Drawing on a growing body of research from mindfulness meditation, her own work on sensory processes, and ancient texts, Cathy explains these Eastern practices develop your Western brain in areas that span physical health as well as mental and emotional well-being.

Video PodcastAired date: 6/13/2011 12:00:00 PM Eastern Time

Audio PodcastAired date: 6/13/2011 12:00:00 PM Eastern Time