Podcasts about Silbert

Dr. Suzanne Silbert, Microbiology Director for Tampa General Hospital, presents this introductory talk on the basics of the microbiology lab for 2025. Dr. Silbert begins with an overview of clinical microbiology, and then reviews the basic classification standards for bacterial organisms, viruses and fungi. She then goes on to discuss culture cultivation techniques, including the use of liquid, solid, or semi-solid media. The speaker then covers identification systems for bacterial organisms, including MALDI-TOF, Disk-Diffusion, and molecular diagnostic techniques.

Vascular cognitive impairment is a common and often underrecognized contributor to cognitive impairment in older individuals, with heterogeneous etiologies requiring individualized treatment strategies.  In this episode, Katie Grouse, MD, FAAN speaks with Lisa C. Silbert, MD, MCR, FAAN, an author of the article “Vascular Cognitive Impairment,” in the Continuum December 2024 Dementia issue. Dr. Grouse is a Continuum® Audio interviewer and a clinical assistant professor at the University of California San Francisco in San Francisco, California. Dr. Silbert is is co-director at Oregon Alzheimer's Disease Research Center, a Gibbs Family Endowed professor of neurology, a professor of neurology at Oregon Health & Science University, a staff neurologist, director of Cognitive Care Clinic, and director of the Geriatric Neurology Fellowship Program at Portland Veterans Affairs Health Care System in Portland, Oregon. Additional Resources Read the article: Vascular Cognitive Impairment Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Full transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum Journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Grouse: This is Dr Katie Grouse. Today I'm interviewing Dr Lisa Silbert about her article on vascular cognitive impairment, which is part of the December 2024 Continuum issue on dementia. Welcome to the podcast and please introduce yourself to our audience.  Dr Silbert: Hi Katie. Thanks for having me here today. Like you mentioned, my name is Lisa Silbert. I am a behavioral neurologist at Oregon Health and Science University and my research focus is in the area of vascular contributions to cognitive impairment and dementia. Dr Grouse: It's such a pleasure to have you and I really enjoyed reading your article. Just incredibly relevant, I think, to most practicing general neurologists, and really to any subspecialty. I'd like to start by asking, what do you think is the main takeaway point of your article for our listeners?  Dr Silbert: Yeah. I think, you know, the field of vascular cognitive impairment has changed and evolved over the last several decades. And I would say the main take-home message is that vascular cognitive impairment or vascular dementia is no longer a diagnosis that is only considered in someone who's had acute decline following a clinical stroke. That we have to expand our awareness of vascular contributions to cognitive impairment and consider other forms of the disease that can cause a more subacute or slowly progressive form of cognitive impairment. And there are many, many forms of vascular cognitive impairment that present in a more slowly progressive manner. The other thing I would say as a major take-home message is that we know that cerebrovascular disease is a very common copathology with other forms of dementia and that it lowers one 's threshold for manifesting cognitive impairment in the context of multiple pathologies. And so, in this way, vascular cognitive impairment should be considered as a contributing and potentially modifiable factor in any dementia.  Dr Grouse: I found that last point just really, really fascinating. And also, you know, the reminder that a combination of pathologies are more common than any one. To your initial point, I'm actually curious, could you kind of outline for us how you approach diagnosing vascular cognitive impairment?  Dr Silbert: Yeah. So with everything in neurology, a lot of it comes down to the initial history taking. And so part of the work up always includes a very detailed history of the presentation of cognitive impairment. Any time there is an acute change in cognition, vascular contribution should be considered, particularly if it's in the context of a clinical stroke or some kind of event that might have lowered cerebral blood flow to the brain. And then having said that, I already mentioned there are many forms of vascular cognitive impairment that can mimic neurodegenerative disease in terms of its course. So being more slowly progressive. And so because of that neuroimaging, and in particular MRI, has become an extremely valuable tool in the workup of anyone who presents with cognitive impairment in order to evaluate contributions from cerebral vascular disease. And so, MRI is a really helpful tool when it comes to teasing out what may be contributing to a patient's clinical syndrome, as well as their other comorbid medical issues, including stroke risk factors and other kind of medical conditions that might contribute to reduce cerebral blood flow. Dr Grouse: I'd love to talk a little bit more about that. You know, as is often the case with neurologic disease associated with vascular pathology, the importance of prevention, you know, focusing on prevention of vascular diseases is so important. What are some things that we can make sure to focus on with our patients and, you know, particularly anything new to be aware of in counseling them? Dr Silbert: Yeah, I'm really glad you asked me that question because like I mentioned, you know, cerebral vascular disease is so common, it lowers one's threshold for cognitive impairment in the face of other age-related brain pathologies. And so, it's really important for all of us to focus on preserving our cognitive health, even starting in midlife. And so, there are a number of areas that I counsel my patients on when it comes to preserving cerebral health and maximizing cerebrovascular health. And so, these stem from the American Heart Association's Life's Essential 8 because we know that preserving cardiovascular health is likely going to also preserve cerebral vascular health. And so, some of the things that I'm very commonly discussing with my patients are controlling stroke risk factors such as blood pressure, blood sugars and cholesterol, maintaining a healthy weight, and then also working towards a lifestyle that includes a healthy diet, no smoking, regular exercise. And then new within the last couple years is also the recommendation that people get adequate sleep, which is something that hasn't been focused on previously. Dr Grouse: I was really interested in reading your article to learn about enlarged perivascular spaces and the role as a mediating factor in the interaction between through a vascular dysfunction and development and progression of neurodegenerative pathology. Can you elaborate on this further? Dr Silbert: So, this is an area that's still largely unknown in the field, and it's an area where there's a lot of emerging work being done. The short answer is, we really don't know with great certainty how it directly connects with accumulating Alzheimer's pathology. But there is some evidence to suggest that the perivascular space is involved in the clearance of toxic solutes from the brain, including Alzheimer's disease pathology. And so there's a lot of work looking at how potentially cerebrovascular risk factors might affect the clearance of those toxic solutes through the perivascular space, including pulse pressure changes that might occur with accumulating cerebrovascular disease and other potential contributors. But one thing I can say with more certainty is that the, you know, location of perivascular spaces is thought to help distinguish those who might have cognitive symptoms due to cerebrovascular disease versus due to cerebral amyloid angiopathy. Or I guess I should say location is helpful in terms of recognizing vascular contributions to cognitive impairment that's due to arteriolosclerosis versus that due to cerebral amyloid angiopathy. In so much that… when we see a lot of perivascular spaces in the basal ganglia in the subcortical structures, that is thought to be more associated with arteriolosclerosis and hypertension type related vascular cognitive impairment. Whereas when we see multiple perivascular spaces within the centrum semiovale, that tends to be more associated with cerebral amyloid angiopathy. Dr Grouse: That's so interesting. And on the topic ofcerebral amyloid angiopathy, you did go into this a good deal. And you know, I think I encourage everybody to revisit the article to remind themselves about, you know, the findings that can increase the suspicion of tribal amyloid angiopathy. However, you also talked about transient focal neurologic episodes, which I think is just a great reminder that, you know, these can occur in this setting and definitely not to miss. Tell us more about what to look for with these types of episodes.  Dr Silbert: Transit focal neurologic episodes can be very difficult to tease apart from a transient ischemic attack. And these transient focal neurologic episodes due to CAA can present in a number of different ways. And I think the important take home message for that is that in people who have neuroimaging evidence of CAA to inform them that they are at increased risk for having these focal neurologic episodes and that if they do present to a hospital or an emergency department with any kind of neurologic event, that those treating them are aware that they have evidence of CAA on their neuroimaging because the treatment of course is quite different. So, it's someone presenting with ATIA who has transient neurologic symptoms might be considered urgently to get a thrombolytic or, you know, TPA, whereas someone who has known cerebral amyloid angiopathy or suspected CAA, they likely already have microbleeds on their neuroimaging and in those cases thrombolytics and TPA would be contraindicated and not helpful in terms of the etiology of their neurologic symptoms. Dr Grouse: That's a really good point to make. And I think also in your article you mentioned the use of aspirin if you're suspecting ATIA versus a, you know, a transient amyloid related focal neurologic episode. You know, one you would treat with aspirin and the other one you wouldn't.  Dr Silbert: That's right.  Dr Grouse: Another sort of interesting topic you delved into was cerebral microinfarct and how this can also contribute to vascular impairment. Could you elaborate a little more on that? Dr Silbert: Yeah. So cerebral microinfarcts are kind of the hidden cause of or a hidden cause of vascular cognitive impairment. And it's extremely challenging because by definition they are not visible on routine clinical neuroimaging. It's something that we are more aware of based on pathological studies and neuroimaging studies that have been done at ultra-high field strength like 7T MRI. And so, we are just learning more about how prevalent they are in certain conditions and how we can only look at these after death when we're looking at brain tissue and then go back and realize that these play a significant role in cognitive decline when someone is alive. It's important to understand that we're probably only appreciating kind of the tip of the iceberg when we're evaluating a patient and looking at their neuroimaging. That what we're actually seeing on MRI are only the things that are actually quite relatively big and obvious. And that a lot of these neuroimaging features of vascular cognitive impairment are actually associated with pathologic features that we're missing such as microinfarcts. But the hope is that by treating all individuals, particularly those who already have signs of vascular cognitive impairment, by modulating their stroke risk factors and focusing on maintaining brain health, that those will, interventions will also reduce the incidence of microinfarcts. Dr Grouse: What do you think is the greatest inequity or disparity you see in treating patients with vascular cognitive impairment? Dr Silbert: I think the greatest disparity is- really starts way before I treat a patient. That relates to really focusing on healthy lifestyle factors early in life and being able to, you know, afford fruits and vegetables, and having the advantages of being able to exercise regularly, and just being aware that all of these things are extremely important before older age. So, these are things that, you know, I think more education and awareness and greater access to healthcare will definitely improve access to. Even preventative healthcare is a disparity and not available across all of the population and geographic locations. So, I think of the- all the dementias, vascular cognitive impairment probably has the greatest association with health and social disparities in terms of primary prevention and access to care.  Dr Grouse: All really important things to consider. I have to say when, you know, reading your article, dare I say I came away with a little bit of hope thinking, you know, even with, you know, how little we still, you know, or how much we still need to do to really learn how to fight Alzheimer's and, you know, prevent it and, and, you know, help with its progression. The idea that in so many cases, even just doing what we can to prevent the vascular or cognitive impairment can really help any type of dementia. That was really a strong message for me. Do you mind elaborating on that a little more?  Dr Silbert: No, not at all. I agree. I really am hopeful about the prevention and treatment of dementias and through the treatment and prevention of cerebrovascular disease. I think that is a true reality, just like, you know, as we were discussing before, the treatment and prevention of cerebrovascular disease really should be a part of the treatment of any type of cognitive impairment and recommendations for prevention of cognitive impairment. This is the, you know, one thing we know is largely modifiable and preventable in most cases. I think the, really the key thing is just education and making sure that people understand that these are things that really need to be, they need to be engaged in in midlife and that it's much harder to reverse these- the damages once you have them in later life. Having said that, I do think that there's greater awareness of maintaining healthy lifestyle and maintaining awareness of stroke risk factors. And I think we're already starting to see a reduction in dementia worldwide in several large population-based studies, and probably that is due to more attention to the modifying stroke risk factors. So, I agree with you, it's very encouraging.  Dr Grouse: Is there anything exciting on the horizon that you can tell us about that we should all be keeping our eyes out for? Dr Silbert: Yeah. So, you know, I'm really interested in this connection between vascular cognitive impairment and Alzheimer's disease. And it's a real area of exciting new research. And so I think we're going to have more answers as to how, whether and how, cerebrovascular disease is directly linked to accumulating neurodegenerative disease or neurodegenerative pathologies. The other area that's, I think, really exciting, that's moving forward, is the in the area of blood-based biomarkers for vascular cognitive impairment. As these emerge, we'll be able to really identify those at greatest risk for vascular cognitive impairment, but also identify novel mechanisms that lead to VCI that can be targeted for therapeutic intervention. Dr Grouse: Well, I'm really excited to see what's coming down the pipeline and what more we'll learn in this area. So, thank you so much for everything you've done to contribute to this field. Dr Silbert: Yeah.  Dr Grouse: I wanted to ask a little bit more about you. What drew you to this work?  Dr Silbert: Well, actually, so my very first published manuscript in medical school was a case report and review on MELAS, which is mitochondrial encephalopathy with lactic acidosis and strokelike syndrome. And so, I was really fortunate to have Dr Jose Biller, who is a renowned expert in stroke and cerebrovascular disorders, as my mentor for that paper. And so, that got me really interested in neuroimaging findings of cerebral vascular disease. And so when I was a fellow at Oregon Health and Science University, I was then really fortunate to  be able to work with Jeffrey Kaye's oldest old population. And in working with that population, I really became interested in their neuroimaging findings of these white matter lesions and just realizing how prevalent they were in that population, you know, it just led me to start investigating their clinical significance and etiology, which kind of led me along this path. Dr Grouse: You know, Lisa, thank you so much. I really learned a lot from your article, and I think our listeners will definitely find that it was very helpful for their practice. Thank you so much for joining us. Dr Silbert: Thank you so much, Katie. It's been really fun.  Dr Grouse: Again, today I've been interviewing Dr Lisa Silbert, whose article on vascular cognitive impairment appears in the most recent issue of Continuum on dementia. Be sure to check out Continuum audio episodes from this and other issues. And thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/AudioCME. Thank you for listening to Continuum Audio.

Die Schritte von Esel und Teddy hallten gedämpft durch Raum 2700 des Harvard Art Museums. Fünfzig Jahre Freundschaft hatten sich in ihren leicht gebeugten Körpern eingegraben, in den Falten um ihre Augen, in der Art, wie sie sich bewegten - synchron und doch unterschiedlich. Ihre Podcast-Jahre hatten ihnen mehr als nur eine Rente eingebracht: Sie hatten sich ein Ritual geschaffen – das Bereisen der bedeutendsten Museen der Welt, ein stummes Bekenntnis ihrer noch immer wachen Intelligenz. Vom Logan Airport aus, diesem architektonischen Ungetüm, das Boston wie eine industrielle Lunge durchatmet – grau, präzise, unbarmherzig – waren sie am Morgen gelandet. Sie spürten noch den kalten Dezembertag, als sie vor Whistlers Nocturne standen. Der bläulich-silberne Nachthimmel schien nicht nur das Gemälde zu durchdringen, sondern auch ihre Erinnerungen – vage, geheimnisvoll, mit verborgenen Nuancen. Esel räusperte sich. Ein Geräusch, das wie ein angefangener Satz klang. "Weißt du noch", begann er, und Teddy wusste sofort, worauf er anspielte, "wie wir damals dieses Quiz gegen Johannes und Stefan verloren haben?" Teddy nickte. Sein berühmtes Lachen – einst so präsent wie sein Atmen, dass es beinahe Teil seiner Physiologie gewesen war – es existierte nicht mehr. Es war an jenem Tag gestorben, an dem mehr als nur ein Spiel verloren ging. Ein Lachen, das früher jede Bemerkung, jeden Gedanken durchdrang, war nun eine Leerstelle, ein stummes Trauma. Der Podcast ihrer Gegner – seinen Namen hatten sie längst vergessen. "Vermutlich etwas total Sinnloses oder irgendwas mit Piraten", murmelte Esel und versuchte, die Schwere des Moments zu brechen. Aber Teddy blieb stumm, sein Blick fest auf die changierenden Blau- und Silbertöne geheftet. Die Niederlage war mehr als ein intellektueller Moment gewesen. Es war eine Häutung, ein Prozess, bei dem etwas Wesentliches von ihnen abfiel. Eine Demütigung, die sich wie ein chronischer Schmerz eingenistet hatte – mal pochend, mal unterschwellig, aber immer präsent. "Wir haben nicht nur ein Spiel verloren", flüsterte Teddy, und seine Stimme war so leise, dass sie fast im Rauschen der Museumsstille unterging, "sondern unsere Selbstachtung." Esel nickte. Die Erinnerung war wie dieses Bild – scheinbar klar, aber voller verborgener Schichten, Nuancen, die sich dem ersten Blick entzogen. Johannes und Stefan – Namen, die nun wie Geister durch ihre gemeinsame Geschichte schwebten. Seit diesem Tag hatten sie nie wieder Kontakt aufgenommen. "Glaubst du, sie denken noch an uns?" fragte Esel. Teddy zuckte kaum merklich mit den Schultern – eine Bewegung, die mehr Resignation als Gleichgültigkeit ausdrückte. "Ich schätze, nicht mehr als wir an sie." Das Bild pulsierte plötzlich, schien zu atmen – ein stummer Zeuge ihrer jahrzehntelangen, unausgesprochenen Trauer. Ein Dokument des intellektuellen Versagens, festgehalten in Blau und Silber. Draußen begann die Dämmerung, blau und silbern – genau wie Whistlers Nocturne. https://www.nytimes.com/interactive/2024/07/20/upshot/attention-experiment.html

In this episode, Lyell K. Jones Jr, MD, FAAN, speaks with Lisa C. Silbert, MD, MCR, FAAN, who served as a guest editor of the Continuum® December 2024 Dementia issue. They provide a preview of the issue, which publishes on December 2, 2024. Dr. Jones is the editor-in-chief of Continuum: Lifelong Learning in Neurology® and is a professor of neurology at Mayo Clinic in Rochester, Minnesota. Dr. Silbert is co-director at Oregon Alzheimer's Disease Research Center, a Gibbs Family Endowed professor of neurology, a professor of neurology at Oregon Health & Science University, a staff neurologist, director of Cognitive Care Clinic, and director of the Geriatric Neurology Fellowship Program at Portland Veterans Affairs Health Care System in Portland, Oregon. Additional Resources Continuum website: ContinuumJournal.com Subscribe to Continuum: shop.lww.com/Continuum More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @LyellJ Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology, clinical review and CME journal from the American Academy of Neurology.  Thank you for joining us on Continuum Audio, a companion podcast to the journal.  Continuum Audio features conversations with the guest editors and authors of Continuum who are the leading experts in their fields. Subscribers to the Continuum Journal have access to exclusive audio content not featured on the podcast. If you're not already a subscriber, we encourage you to become one. For more information, please visit the link in the show notes.  Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum: Lifelong Learning in Neurology. Today I'm interviewing Dr Lisa Silbert, who recently served as Continuum's co-guest editor for our latest issue on dementia alongside Dr Lianna Apostolova. Dr Silbert is a professor in the Department of Neurology at Oregon Health and Science University of the School of Medicine in Portland, Oregon, where she's also the director of the Neuroimaging Core and now the co-director of the Alzheimer's Disease Research Center. She also serves as director of the dementia clinic at the VA Portland Healthcare System. Which, Dr Silbert, sounds like a lot of work? Anyway, welcome. I really appreciate you taking the time to join us today and co-guest editing this issue. Why don't you introduce yourself a little bit to our listeners?  Dr Silbert: Well, thank you so much for interviewing with me today and for inviting me to be the guest, co-guest editor of this issue. It's a really exciting time for dementia care and dementia research. As you already said, my name is Lisa Silbert. I'm in Oregon Health and Science University in Portland, Oregon. I've been involved in caring for dementia patients and their families for over twenty years now and been involved in a lot of really exciting research during that time. But I would say now is probably the most dynamic time in dementia research and care that I've seen. So, it's really, really exciting to be here.   Dr Jones: It really is an interesting time. So, I look back  in our last issue of Continuum focusing on dementia came out in 2022, which doesn't sound like that long ago, but a lot has changed, right? With the anti-amyloid monoclonals for Alzheimer's disease, new biomarkers and so on. And as the guest editor, you have this unique view, Dr Silbert, of the issue and the whole topic of dementia. As you were reading these really outstanding articles, what was the biggest “aha” moment for you or the biggest change in practice that you saw that's come up over the last couple of years?     Dr Silbert: I think, you know, in reading through the different manuscripts or chapters in this issue, it really struck home the advances that have been made throughout all the different areas of dementia. Not just- so, we hear a lot about Alzheimer's biomarkers and Alzheimer's treatments on the horizon, which is really exciting, but this is happening across other dementias as well. There's biomarkers on the horizon for a Lewy body disease and potentially for some of the frontaotemporal dementias. And so that to me really struck home as this is really, across the board, a change in the entire field that we're looking at.  Dr Jones: That is exciting. And I'd like to come back to some of those biomarker developments because I think that's an area where we've really been lacking in neurology as a specific way to diagnose those disorders. I think a topic which you just alluded to that a lot of our listeners and readers are thinking about are those antiamyloid monoclonal therapies for Alzheimer's disease. So, addicanumab, lecanumab and most recently the approval of donanemab. For these drugs specifically, how are you using them in your practice and how should our listeners be thinking about these drugs?  Dr Silbert: These are, you know, relatively new, really exciting new and emerging therapies for Alzheimer's disease. They are shown to remove amyloid from the brain. Patients who have clinical manifestations of Alzheimer's disease, and that is those in the stages of mild cognitive impairment or mild dementia. We are using lecanemab at Oregon Health and Science University through our therapeutics and clinical units. It's a really exciting time and it's a time where we have to be, also, cautious about who undergoes these therapies. So being really informed about the use, who's appropriate to undergo these therapies, what kind of safety tests need to be undergone, how do you assess risk in individual patients so that you can counsel them.  So, all of these factors need to be weighed in when you're making a decision about whether or not to treat a patient with a monoclonal antibody therapy. And specifically, we do neuroimaging to assess whether there are already the presence of microhemorrhages in the brain. We do genetic testing to look for APOE 4 genotypes that can increase the risk of Aria, which is amyloid-related imaging abnormalities. And all of these factors go into how we counsel patients and discuss whether or not to pursue treatment with monoclonal antibodies.    Dr Jones: So certainly a complex patient selection process and drug administration and monitoring of therapy for those patients.  And that- it brings to mind for me how we already have too few neurologists in the US. And now for a really prevalent disorder, Alzheimer's disease, we're making it a lot more complicated to deliver these new disease-modifying therapies. What do you think or what do you see as the role of the neurologists in caring for patients with dementia? And do these developments change that role?  Dr Silbert: For now, I think these developments make it even more important in a way that neurologists are involved in making a very specific clinical diagnosis of which dementia is playing a factor in the patient 's clinical presentation. I think one thing to note is with these emerging biomarkers, a lot of them can be positive before there are clinical symptoms and multiple etiologies are also very prevalent. And so just having one positive biomarker, it doesn't necessarily tell you what's going on with an individual patient. You need to take the whole picture into consideration. So, I think a really detailed evaluation by the neurologist, especially with these emerging therapies that have potential risks, is extremely important right now. Just getting a test is really not sufficient. You really have to take the entire clinical picture into account and know the ins and outs of the risks involved in these disease-modifying therapies.  Dr Jones: Which brings us back to something you mentioned earlier, right? Which is good news. We have on the horizon new potential biomarkers for other neurodegenerative causes of dementia. I can foresee and maybe I'm, you know, being an alarmist here, Dr Silbert, but if we have sensitive biomarkers for other neurodegenerative conditions, we know patients often have copathologies. Is that going to help clarify things? Is it going to confuse us? How is that going to work?  Dr Silbert: Well, I think ultimately, it's going to help clarify things. Because there are multiple pathologies that are common in age related cognitive impairment, any kind of additional specific input that we can get with different biomarkers is going to be helpful in putting the pieces together to come up with what's happening clinically with each individual patient. Ultimately, I think these biomarkers, they're not- any one biomarker isn't going to be a solution to diagnosis, but putting them together to help improve early and accurate diagnosis is really the goal here. Having a very early diagnosis, having a very accurate diagnosis will improve our ability to give prognosis and also improve effective treatment strategies moving forward. I think that these biomarkers have the promise in facilitating that for us.  Dr Jones: And progress is always a good thing. We just have to learn how to adapt and use the evidence appropriately. There have been and I think most of our listeners will be familiar with some of the controversies related to these, these new disease-modifying drugs for Alzheimer's disease. Do you want to walk us through a couple of those, and what are your thoughts about those controversies?  Dr Silbert: Yeah, these new therapies, they're very exciting for everyone in the field, but they, like you mentioned, they're not without their controversies. I think one controversy or one potential downside to these therapies is access to them. Like you already mentioned there, there's really not enough neurologists out there. There's not enough behavioral neurologists out there. There's limitations to infusion centers, sites and prescribers. Access to these therapies is is significantly limited. They are requiring infusions quite frequently. So, if you're not living near specialty care, you're not really able to feasibly undergo these kinds of treatments. Another controversy is the fact that the treatment effects are considered by some to be fairly modest when looking at the clinical data and in association with that, there are risks involved. Like I already mentioned, there's the amyloid-related imaging abnormalities, which sounds kind of like a benign thing, but they really consist of microhemorrhages that can lead to bigger hemorrhages and edema in the brain. These risks are relatively small - they are seeing more commonly in those who have a specific genotype, an APOE E 4 genotype - but they're risks nonetheless.  And so, there's controversy about the risk-benefit ratio and access to care with these new therapies.  Dr Jones: It's very exciting, but we should be cautious, right? I recall a few years ago as a program director, a neurology residency program director, interest in different areas of neurology would often follow developments in those areas, right? Lots of interest in autoimmune neurology when those developments would proceed in neuro oncology, etc. And I wonder if the therapeutic advances in in behavioral neurology and neurodegenerative cognitive disorders, I wonder if that's going to stimulate interest among our trainees to pursue behavioral neurology? Do you have a view on that or have you seen much change in interest in in this field?  Dr Silbert: You know, we are seeing a lot more interest in our trainees. The residents are very interested in these new therapies and how to apply them. And I'm really excited about that.  I'm hopeful that this will stimulate interest in the field. And we need those specialists, we need those sub specialists to undergo fellowship training in behavioral neurology and geriatric neurology so that we have more access to the subspecialty care and delivering these new therapies. So, I agree with you, I'm hopeful about it and I am seeing new interest in our trainees about these new therapies.  Dr Jones: We can hope so. And all the other fellowship directors will be anxious if neurology residents start leaving to go into behavioral neurology. But there's certainly demand. And I know that under the best of circumstances, dementia is so common. It's something that we have to care for in partnership with primary care and community resources. And these disease-modifying therapies capture a lot of attention, but it's really a small part of the continuum of care of these patients. And Dr Silbert as an expert, you know, if we put that disease-modifying therapy to the side for a second and just said, well, what are the biggest gaps in the care for patients with dementia? What do you see as those biggest gaps and, and what can we do to fix them at not just a neurology level, but at a societal level?  Dr Silbert: That's a big question. And you know, what I see almost every day are gaps in the support mechanisms for families who are caring for patients with dementia. These caregivers are under a lot of stress and oftentimes they just don't have the resources to take care of somebody who at some point will often need twenty-four hour care and supervision. Caregivers are older, usually of older age themselves and have their medical issues as well. And then we're just not doing a good job as a nation in in supporting patients and their families with like supportive care and respite care that's really needed. So, you know, I'm not just seeing and treating patients with dementia, but I'm seeing and I'm really trying to support and care for those who are taking care of patients with dementia. To me, that's the biggest gap in our system. Dr Jones: Yeah. And as I look through this issue of Continuum, we touched on not only the conventional topics in dementia and behavioral neurology. I'm really happy in hindsight that we have invited some discussion of the psychiatric symptoms in dementia, which I think are really important and often underrecognized and maybe undermanaged or mismanaged, and really also focusing on the caregiver burden and support services. We do have an article dedicated to that as well, and I think that'll be useful to our readers and listeners when we when we publish those podcasts. We we've heard this year especially a lot of public conversation about cognitive impairment and dementia. I sometimes wonder if that public attention is helpful and constructive for the population of patients with dementia. Sometimes I wonder if that conversation is counterproductive. What's your take on that?  Dr Silbert: You know, I think it's- it can be a mixed bag, but ultimately, it's in the conversation. We're talking about it. And I think that's only a good thing. There's more public awareness of it.  There is more interest in therapies. So, I think at the end of the day, talking about it, making it more prevalent in the ether, it stimulates the conversation and discussion. And even if there's controversies about it, we're talking about it. And I think that's kind of the first step in acknowledging that we need more support, we need more therapies.  Dr Jones: Yeah, I agree. And I think often patients with neurologic disorders and their caregivers and families often appreciate being seen.   Dr Silbert: Yeah, no, absolutely true. So, I'd say in regards to the monoclonal antibody treatments, you know, despite the controversies with these new treatments, I think there's a real promise and a real hope and a real excitement across a lot of behavioral neurologists, including myself, that this is just the beginning. That even if these first line, first generation therapies maybe have downsides, that there'll be second generation and third generation variations on these kinds of treatments that are going to be more accessible, have less side effects and hopefully be more clinically effective. And, and down the line, the other real hope for the field is that these maybe second generation therapies will actually delay the onset or prevent clinical manifestation of the disease. And that's the real goal here.  Dr Jones: And that's a great segue to the to the next thing I wanted to ask you about and you, you may have already answered the question. We talked about how we have and will have new biomarkers which will help us with diagnosis. We have hopefully the first phase in increasingly effective disease modifying therapies for Alzheimer, maybe prevent Alzheimer's disease. Wouldn't that be great? Are there any other things on the horizon that you see maybe for other neurodegenerative disorders from a therapeutic perspective? What do you, what do you think the next big thing will be in that area?  Dr Silbert: Well, that's a great question. I think, you know, there's a lot of exciting research in Lewy body dementia and targeting alpha synuclein pathologies. We really need biomarkers.  So, we're ways off from therapeutics, but I think there's a lot of exciting progress in that area.  Dr Jones: So, like many areas of neurology, there are rewarding and challenging aspects to the care of these patients. What  do you- what's the most rewarding aspect of your practice, Dr Silbert?   Dr Silbert: You know, a lot of… I hear from trainees over the years that, you know, they can't imagine or it's difficult for them to think about caring for patients who have a neurodegenerative disease that has no cure. But I feel like that's a lot of what neurologists do. We don't necessarily cure all diseases, but we treat the patient throughout their disease process. And to me that is extremely satisfying. You know, I enjoy listening to patients' stories and hearing about what they have been through over the years. And I really feel, like, appreciated for the care that I provide in giving not just an accurate diagnosis, which a lot of people come in lacking, but talking about future planning and, really, treatment throughout the course of the disease. And I was in clinic yesterday and talking to one of my patients' caregivers, and we were talking about a particularly difficult behavioral manifestation that her husband was going through. And we were talking through how to manage it. And she said to me, you know, Dr Silbert, I really feel like I have a partner in going through this disease. And you know, that's kind of what it's all about for me. So, to me, it's extremely rewarding field. It's also a very exciting field, especially right now with all these new biomarkers and treatments. So, I just think there isn't a better area of neurology to be involved in right now.   Dr Jones: What a great place to land and end the interview. And I hope our listeners and our readers really do enjoy this issue. It's really a fantastic, not just an update, but a survey of a very dynamic aspect of the field of neurology. And Dr Silbert, I want to thank you for joining us and thank you for such a thorough and fascinating discussion on caring for patients with dementia.    Dr Silbert: It was my pleasure. Thank you.    Dr Jones: Again, we've been speaking with Dr Lisa Silbert, co-guest editor, alongside Dr Leanna Apostolova for Continuum 's most recent issue on dementia. Please check it out, and thank you to our listeners for joining us today.  Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. Thank you for listening to Continuum Audio. 

Mit Mark, Philipp und unserem heutigen Gast Martin Silbert, haben wir einen Kunden, zwei Wohnmobil-Händler und drei Camping-Youtuber bei Inside Camping! Während Philipp mit GÜMA hauptsächlich im Bereich Neufahrzeuge tätig ist, kommt Martin mit seiner Firma Wohnmobil Silbert, ausschließlich aus dem Gebrauchtfahrzeugmarkt. Es geht unter anderem um die verrückte Idee sich in jungen Jahren selbständig zu machen, den An- und Verkauf von gebrauchten Wohnmobilen, das generelle Marktgeschehen aus zwei bzw. drei interessanten Perspektiven und vieles, vieles mehr! Viel Spaß beim Anhören!

Das haben wir ja schon ganz lange nicht mehr gemacht - ein Pflanzenportrait. Carla meinte, dass müsse unbedingt mal wieder sein.

Host Helene Braun breaks down the latest news in the crypto industry from the $400 million leverage flush out to New York Attorney General Letitia James' pushback against DCG, Silbert's motions to dismiss the fraud case.To get the show every day, follow the podcast here."CoinDesk Daily" host Helene Braun breaks down the biggest headlines impacting the crypto industry today, including bitcoin and ether's reaction to the $400 million leverage flush out. Plus, Fidelity International has selected JPMorgan's Onyx Digital Assets blockchain to tokenize a money market fund and New York Attorney General Letitia James pushed back against DCG, Silbert's motions to dismiss the fraud case.-This episode was hosted by Helene Braun. “First Mover” is produced by Jennifer Sanasie and Melissa Montañez and edited by Victor Chen.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome back to Progressively Incorrect. My name is Dr. Zach Groshell and this week I am excited to be bringing you the 2nd episode of my series on Direct Instruction, this time with Linda Carnine, Susie Andrist, and Jerry Silbert. They are going to be talking about what it was like to be on the … Continue reading S310: Linda Carnine, Susie Andrist, and Jerry Silbert on What Was Project Follow Through?

Welcome back Zig fans, my name is Dr. Zach Groshell. I am a teacher, a parent, and the host of this show, the Direct Instruction podcast. The DI podcast is brought to you by NIFDI, which stands for the National Institute for Direct Instruction, and today we are going to be talking about Project Follow […]

Assine o Café BVrasil em https://canalcafebrasil.com.br  Link para o livro: https://livrariacafebrasil.com.br/psicopatas-domesticos No episódio de hoje trazemos Renata Silbert, que tem uma carreira profissional diversificada, de executiva em grandes empresas a profissional do mercado financeiro. Sentindo que precisava complementar sua experiência profissional com questões ligadas à gente, Renata decide cursar psicologia aos 47 anos, passando a clinicar. Essa experiência a colocou em contato com histórias impressionantes, que acabaram por inspirar o livro Psicopatas Domésticos. Uma conversa fascinante sobre o psicopata que está na sala ao lado. Ou ao seu lado. Ou dentro de você.  See omnystudio.com/listener for privacy information.

Assine o Café BVrasil em https://canalcafebrasil.com.br  Link para o livro: https://livrariacafebrasil.com.br/psicopatas-domesticos No episódio de hoje trazemos Renata Silbert, que tem uma carreira profissional diversificada, de executiva em grandes empresas a profissional do mercado financeiro. Sentindo que precisava complementar sua experiência profissional com questões ligadas à gente, Renata decide cursar psicologia aos 47 anos, passando a clinicar. Essa experiência a colocou em contato com histórias impressionantes, que acabaram por inspirar o livro Psicopatas Domésticos. Uma conversa fascinante sobre o psicopata que está na sala ao lado. Ou ao seu lado. Ou dentro de você.  See omnystudio.com/listener for privacy information.

Huckleberry Youth, the non-profit providing care and housing for underserved youth, celebrated 50 years back in 2017. In Part 1 of this episode, we meet Huckleberry consultant/advisor Denise Coleman and the organization's CEO/executive director, Doug Styles.   Denise was born at what is now Kaiser's French Campus on Geary. Denise, who is Black, shares the story of the hospital making her dad pay cash for their labor and delivery services, while it was obvious that white folks were allowed to make installment payments.   Born and raised in the 1950s and Sixties, Denise and her family lived in the Haight/Ashbury neighborhood, as it was known then (now we call it Cole Valley) on Belvedere Street. She has three sisters and a brother, her dad worked two jobs usually, and her mom stayed home. She describes a childhood that was fun, filled with activities like roller skating, skateboarding, and homemade roller coasters.   Denise was a teenager during the Vietnam War and took part in protests. She describes a history of friction with her mom. When Denise was 16, one of her sisters OD'd on drugs. Still, despite the trauma that came with that, she graduated high school from St. Mary's in 1973. At this point in the podcast, Denise rattles off the San Francisco schools she went to.   After high school, she joined some of her cousins and attended the College of San Mateo. Denise never thought about or wanted to leave the Bay Area, she says. In an apartment on the Peninsula, she and her cousins had "the best time." After obtaining a two-year associate's degree, Denise says she wanted to go to SF State, but didn't connect with it, and so she started working instead. For two years, she flew as a flight attendant for the now-defunct Western Airlines. After that, she collected debt for a jewelry store, then worked as a credit authorizer for Levitz Furniture in South San Francisco.   Denise says she got hung up in the crack epidemic in the Eighties. She started with cocaine, and that led to crack. She was an addict for eight years. She got herself into a rehabilitation program at Delancey Street and stayed in the program for seven years. Her time started in SF, then took her to Santa Monica, North Carolina, and New York state.   In 1998, Denise decided to leave Delancey Street. She got a call from Mimi Silbert, the Delancey founder, with an offer to work at their new juvenile justice program in San Francisco. Denise said no at first, partly because she wanted to stay in North Carolina. But after some persistence from Silbert, in 1999, she said yes and came back to her hometown. After seven years away, The City had changed.   And so Denise helped to establish Delancey Street's Community Assessment and Referral Center (CARC). After its first year, the organization realized that they didn't have the capacity to run the program. Delancey Street asked Huckleberry Youth to take it over, and this is how Denise ended up at Huckleberry.   Doug Styles was born and raised in the Richmond District. He was too young to remember the 1960s and mostly grew up in the Seventies. Doug says he had a lot of fun as a kid, describing riding his bike to the beach and back by himself. He shares the story of going to a late movie in the Mission, so late that when he got out, there were no buses. And so he walked home through the Mission, through the Fillmore, to his home in the Richmond.   He also rattles off San Francisco schools he went to, including Lowell. Doug was in school when the SLA kidnapped Patty Hearst. He was at Everett Middle School when Dan White assassinated George Moscone and Harvey Milk. He speaks to tensions in The City around this time, and Denise joins in to talk about the day of the assassinations.   Doug graduated high school in 1983 and went to UC Santa Cruz, where he majored in theater. He moved to Massachusetts, where he found work in a theater. After a short time out east, he came back to San Francisco and tried unsuccessfully to get into grad school. So he enrolled in a masters program at CIIS for drama therapy. Following that degree, Doug went back east, this time to Connecticut to work at the VA's National Center for PTSD.   After another return to the Bay Area, he got his doctorate in clinical psychology. At the VA, Doug had worked with adults, but the jobs he found here had him working with youth. He had a job on the Peninsula for 10 years, during which time he became a father to two kids, which he says changed him more than anything else.   One day he saw that the Huckleberry Youth executive director was retiring. Doug applied and got the job, and has been with the non-profit ever since.   Check back next week for Part 2 and more on the history of Huckleberry Youth.   Photography by Jeff Hunt   We recorded this podcast in December 2023 at Huckleberry Youth's administrative offices on Geary.

NLW recaps the biggest stories from the last week and a half, including Barry Silbert resigning from the board at Grayscale (clearing the path to an ETF conversion?) as well as the dubious DOJ decision to not pursue campaign finance charges against Sam Bankman-Fried. Today's Sponsor: Kraken Kraken: See what crypto can be - https://kraken.com/TheBreakdown Enjoying this content? SUBSCRIBE to the Podcast: https://pod.link/1438693620 Watch on YouTube: https://www.youtube.com/nathanielwhittemorecrypto Subscribe to the newsletter: https://breakdown.beehiiv.com/ Join the discussion: https://discord.gg/VrKRrfKCz8 Follow on Twitter: NLW: https://twitter.com/nlw Breakdown: https://twitter.com/BreakdownNLW

When the value of a product is eclipsed by the value of its branding, the propaganda becomes the vehicle of self-expression. Social media, the ultimate tool of self-expression, is dominated by personal brands. But a brand doesn't have a “self” — it answers only to sales. In a world where market dynamics dictate the entire human experience, where does this trajectory ultimately lead us? Featuring brands like Liquid Death, MSCHF, and Mattel. BRINK is a creative agency dedicated to reshaping the advertising industry through expanding awareness of our impact on the collective conscience and adopting a more humanist approach. Learn more about our work at brink.com   Website: thisispropaganda.show Email: propaganda@brink.com Instagram: instagram.com/thisispropagandashow YouTube: youtube.com/@thisispropagandashow Slack: bit.ly/propaganda-slack Reddit: reddit.com/r/thisispropaganda   Cohosts: Josh Belhumeur and Malcolm Critcher Producers: Jaclyn Hubersberger and Reed Chandler Story Editor: Matt Decker Additional Audio Engineering: Paul Injeti Original music: Josh Belhumeur   “Big Red Boot.” MSCHF. https://mschf.com/shop/big-red-boot/ “Black Panther (soundtrack).” Wikipedia. https://en.wikipedia.org/wiki/Black_Panther_(soundtrack) Bradley, Bill. 2022. “US Advertising Sales Projected to Pass $300 Billion for First Time Ever in 2022.” Adweek. https://www.adweek.com/convergent-tv/us-advertising-sales-projected-to-pass-300-billion-for-first-time-ever-in-2022/ Ferere, Cassell. 2021. “Brand Blasphemy? What Nike's Move To Sue MSCHF For Lil Nas X ‘Satan Shoes' Tells Us About Pop Culture.” Forbes. https://www.forbes.com/sites/cassellferere/2021/03/30/nikes-move-to-sue-mschf-for-its-lil-nas-x-satan-shoes-tells-us-about-pop-culture/?sh=58f905dc55fc Huddleston Jr., Tom, and Zachary Green. 2022. “Liquid Death CEO Mike Cessario: We chose 'the dumbest possible name' for water.” CNBC. https://www.cnbc.com/2022/11/26/liquid-death-ceo-mike-cessario-we-chose-the-dumbest-possible-name-for-water.html Museum of Broadcast Communications Encyclopedia of Television. 1997. “Colgate Comedy Hour, The.” Television Academy Interviews. https://interviews.televisionacademy.com/shows/colgate-comedy-hour-the Silbert, Jake. 2021. “MSCHF's At All Costs Clothing Line Plays With Prices.” Highsnobiety. https://www.highsnobiety.com/p/mschf-at-all-costs-clothing-line/ Silbert, Jake. 2021. “MSCHF's Guns 2 Swords took The Met Gala, Thanks to Grimes.” Highsnobiety. https://www.highsnobiety.com/p/mschf-guns-2-swords/ Suess, Jeff. 2017. “Our history: P&G put the 'soap' in 'soap opera.'” Cincinnati Enquirer. https://www.cincinnati.com/story/news/2017/10/04/our-history-p-g-put-soap-soap-opera/732149001/ Whitten, Sarah. 2023. “Barbie is highest-grossing domestic film release in 2023.” CNBC. https://www.cnbc.com/2023/08/24/barbie-is-highest-grossing-domestic-film-release-in-2023.html “Your Hit Parade.”  Wikipedia. https://en.wikipedia.org/wiki/Your_Hit_Parade

In a Tuesday, December 26, SEC filing, Grayscale Investments announced that Barry Silbert, the CEO of Digital Currency Group (DCG), the parent company of Grayscale, is resigning from Grayscale's board of directors as of January 1, 2024. According to reports, the SEC is finally warming up to Bitcoin Spot ETF proposals and is expected to make a historic decision by January 10, 2024. The SEC instructed at least two firms to submit final changes by the end of this business week on December 29. ~This episode is sponsored by iTrust Capital~iTrustCapital | Get $100 Funding Reward + No Monthly Fees when you sign up using our custom link! ➜ https://bit.ly/iTrustPaul00:00 Intro00:21 Sponsor: iTrust Capital00:56 BTC Chart01:43 ETF filing deadline03:51 Barry Silbert steps down06:18 Cathie Wood GBTC holdings07:09 SEC's mindset changed08:45 Crypto election year10:47 Crypto "a new category"13:04 When ETH ETF?14:34 Institutions prepping for 202416:59 Crypto has never seen money like this before20:43 Outro#Bitcoin #Crypto #Ethereum~Bitcoin ETF Wave 1 Incoming!

In a rare interview, two Genesis creditors discuss their dealings with the lender and DCG, including the sales pitch that got them to give Genesis new loans after the 3AC debacle. Two Genesis creditors, BJ and Branden, who prefer to use pseudonyms for security reasons, spoke with Unchained about the alleged fraud by the crypto lender and its parent company, Digital Currency Group (DCG). The discussion is one of the first times Genesis creditors have spoken with a media organization about the situation. BJ and Branden explain how they gave more loans to Genesis after it took a $1.1 billion hit from the liquidation of Three Arrows Capital and how they then came to be members of the ad hoc group, a collective of Genesis customers who came together to try and save the company from bankruptcy. They talk about how they now want DCG to pay back the $1.1 billion it owes over a shorter timeframe and to pay back any Bitcoin in actual Bitcoin. The discussion with Unchained followed shortly after New York Attorney General Leticia James filed a lawsuit against Genesis, along with its parent company Digital Currency Group, and Gemini Trust. Listen to the episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Stitcher, Castbox, Google Podcasts, Amazon Music, or on your favorite podcast platform.Show highlights | What NYAG Letitia James alleged in the lawsuit against Gemini, DCG, and GenesisHow BJ and Branden became creditors of GenesisHow Genesis claimed it got into what it called a “liquidity mismatch”How, after the Three Arrows Capital collapse, BJ and Branden were reassured that Genesis had "no issues" and "was back to business" Whether the trading and lending units of Genesis were all part of the same company and why that distinction is important.What the difference is between the ad hoc group and an unsecured creditors committeeWhat the creditors are proposing in order to get their assets backWhy the creditors want to be paid in crypto, not in USDWhether the case will go to litigation and what Silbert can do to avoid itThank you to our sponsors! | Crypto.com | Arbitrum Foundation | Phemex| Popcorn NetworkGuests| Branden, Creditor of GenesisBJ, Creditor of GenesisLinks | Previous coverage of Unchained on Genesis and DCG:Genesis May Be Facing Bankruptcy. Could It Take DCG Down With It?Gemini vs. DCG Is Heating Up. Could Gemini Force Genesis Into Bankruptcy?$630M Due Next Week: Is DCG at Default Risk?NYAG LawsuitUnchained: NY Attorney General Sues Crypto Firms Gemini, Genesis, and DCG for Over $1 Billion FraudThe Block:DCG says it was 'blind sided' by NYAG suit in third quarter shareholder letterGenesis, Gemini, DCG disputesUnchained: Gemini Says DCG Missed $630 Million Payment Last WeekCameron Winklevoss Threatens to Sue DCG and Barry Silbert Over Delays in Genesis ResolutionDCG Calls Gemini Lawsuit a ‘Publicity Stunt' From Cameron WinklevossDCG Calls Gemini's Complaint a PR Campaign in Motion to Dismiss LawsuitFTX and Genesis Reach $175 Million Settlement, Resolving Complex DisputeDCG and Genesis Reach In-Principle Deal With CreditorsGemini and Genesis Creditor Groups Object to In-Principle Deal to Resolve BankruptcyGenesis Winds Down its US Spot Crypto Trading OperationGenesis Sues Parent Company DCG, Seeks Repayment of $600 MillionDCG Proposes Remuneration Plan That Could Enable Gemini Earn Users to Be Made WholeGenesis Winds Down All Crypto Trading Services: ReportGemini Pushes Back on DCG's Remuneration Proposal, Calling it an ‘Attempt to Bait' Earn UsersDisclaimer: Genesis and CoinDesk are both owned by DCG.Unchained Podcast is Produced by Laura Shin Media, LLC. Distributed by CoinDesk. Senior Producer is Michele Musso and Executive Producer is Jared Schwartz. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Two Genesis creditors, BJ and Branden, who prefer to use pseudonyms for security reasons, spoke with Unchained about the alleged fraud by the crypto lender and its parent company, Digital Currency Group (DCG). The discussion is one of the first times Genesis creditors have spoken with a media organization about the situation.   BJ and Branden explain how they gave more loans to Genesis after it took a $1.1 billion hit from the liquidation of Three Arrows Capital and how they then came to be members of the ad hoc group, a collective of Genesis customers who came together to try and save the company from bankruptcy.   They talk about how they now want DCG to pay back the $1.1 billion it owes over a shorter timeframe and to pay back any Bitcoin in actual Bitcoin. The discussion with Unchained followed shortly after New York Attorney General Letitia James filed a lawsuit against Genesis, along with its parent company Digital Currency Group, and Gemini Trust. Listen to the episode on Apple Podcasts, Spotify, Overcast, Podcast Addict, Pocket Casts, Stitcher, Castbox, Google Podcasts, Amazon Music, or on your favorite podcast platform. Show highlights: what NYAG Letitia James alleged in the lawsuit against Gemini, DCG, and Genesis how BJ and Branden became creditors of Genesis, including the role of the influence of MicroStrategy's Michael Saylor how Genesis claimed it got into what it called a “liquidity mismatch” how, after the Three Arrows Capital collapse, BJ and Branden were reassured that Genesis had "no issues" and "was back to business" whether the trading and lending units of Genesis were all part of the same company and why that distinction is important what the difference is between the ad hoc group and an unsecured creditors committee what the creditors are proposing in order to get their assets back why the creditors want to be paid in crypto, not in USD whether the case will go to litigation and what Silbert can do to avoid it   Thank you to our sponsors! Crypto.com Arbitrum Foundation Phemex Popcorn Network Guests: Branden, Creditor of Genesis BJ, Creditor of Genesis Links Previous coverage of Unchained on Genesis and DCG: ​​Genesis May Be Facing Bankruptcy. Could It Take DCG Down With It? Gemini vs. DCG Is Heating Up. Could Gemini Force Genesis Into Bankruptcy? $630M Due Next Week: Is DCG at Default Risk? NYAG Lawsuit Unchained: NY Attorney General Sues Crypto Firms Gemini, Genesis, and DCG for Over $1 Billion Fraud The Block: DCG says it was 'blind sided' by NYAG suit in third quarter shareholder letter Genesis, Gemini, DCG disputes Unchained: Gemini Says DCG Missed $630 Million Payment Last Week Cameron Winklevoss Threatens to Sue DCG and Barry Silbert Over Delays in Genesis Resolution DCG Calls Gemini Lawsuit a ‘Publicity Stunt' From Cameron Winklevoss DCG Calls Gemini's Complaint a PR Campaign in Motion to Dismiss Lawsuit FTX and Genesis Reach $175 Million Settlement, Resolving Complex Dispute DCG and Genesis Reach In-Principle Deal With Creditors Gemini and Genesis Creditor Groups Object to In-Principle Deal to Resolve Bankruptcy Genesis Winds Down its US Spot Crypto Trading Operation Genesis Sues Parent Company DCG, Seeks Repayment of $600 Million DCG Proposes Remuneration Plan That Could Enable Gemini Earn Users to Be Made Whole Genesis Winds Down All Crypto Trading Services: Report Gemini Pushes Back on DCG's Remuneration Proposal, Calling it an ‘Attempt to Bait' Earn Users   Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Suzanne Silbert, Microbiology Director for Tampa General Hospital, presents this introductory talk on the basics of the microbiology lab. Dr. Silbert begins with an overview of clinical microbiology, and then reviews the basic classification standards for bacterial organisms, viruses and fungi. She then goes on to discuss culture cultivation techniques, including the use of liquid, solid, or semi-solid media. The speaker then covers identification systems for bacterial organisms, including MALDI-TOF, Disk-Diffusion, and molecular diagnostic techniques. A robust question and answer session concludes the session

Welcome to Episode 26 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 26 of “The 2 View” – Save time charting & code accurately, dementia, PE in pregnancy, and the PCN shortage. PCN Shortage Ault, A. FDA Drug Shortages. Current and Resolved Drug Shortages and Discontinuations Reported to FDA. FDA issues new rule on drug shortages. Community Oncology, 9(1), 34. U.S. Food & Drug. Published April 26, 2023. Accessed May 9, 2023. https://doi.org/10.1016/j.cmonc.2011.12.003 Bendix, A. Shortage of penicillin limits access to the go-to drug for syphilis. NBC News. Published April 27, 2023. Accessed May 9, 2023. https://www.nbcnews.com/health/health-news/shortage-penicillin-limits-access-go-drug-syphilis-rcna81777 Global shortages of penicillin. Shortages of benzathine penicillin. Global Sexually Transmitted Infections Programme. World Health Organization. Who.int. Accessed May 9, 2023. https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/stis/treatment/shortages-of-penicillin Dementia Alzheimer's Disease Fact Sheet. Alzheimer's Disease and Related Dementias: Basics of Alzheimer's Disease and Dementia. National Institute on Aging. Accessed May 9, 2023. https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet Home. Alzheimer's Disease and Dementia. Alzheimer's Association. Accessed May 9, 2023. https://www.alz.org/ Silbert, L, Erten-Lyons, D. Memory Loss, Confusion in a 51-Year-Old Fired From Her Job. Medscape. Published March 2, 2023. Accessed May 9, 2023. https://reference.medscape.com/viewarticle/850363 PE in Pregnancy Negaard M. YEARS Algorithm for pulmonary embolism (PE). MDCalc. Accessed May 9, 2023. https://www.mdcalc.com/calc/4067/years-algorithm-for-pulmonary-embolism-pe Stals MAM, Moumneh T, Ainle FN, et al. Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data. J Thromb Haemost. 2023;21(3):606-615. NIH: National Library of Medicine: National Center for Biotechnology Information. PubMed. Published December 22, 2022. Accessed May 9, 2023. https://pubmed.ncbi.nlm.nih.gov/36696189/ Thromboembolism in Pregnancy. ACOG: The American College of Obstetricians and Gynecologists. Acog.org. Practice Bulletin, Number 196. Published July 2018. Accessed May 9, 2023. https://www.acog.org/clinical/clinical-guidance/practice-bulletin/articles/2018/07/thromboembolism-in-pregnancy Charting & Coding 2023 Emergency Department Evaluation and Management Guidelines. ACEP: American College of Emergency Physicians. Acep.org. Last Updated: October 2022. Accessed May 9, 2023. https://www.acep.org/administration/reimbursement/reimbursement-faqs/2023-ed-em-guidelines-faqs American Medical Association. 2023 Emergency Medicine Coding Guide. MDCalc. Accessed May 9, 2023. https://www.mdcalc.com/calc/10454/2023-emergency-medicine-coding-guide CPT Evaluation and Management (E/M) Code and Guideline Changes. AMA: American Medical Association. Ama-assn.org. Accessed May 9, 2023. https://www.ama-assn.org/system/files/2023-e-m-descriptors-guidelines.pdf ICD-10-CM Coding for Social Determinants of Health. AHA: American Hospital Association – Advancing Health in America. Aha.org. Published January 2022. Accessed May 9, 2023. https://www.aha.org/system/files/2018-04/value-initiative-icd-10-code-social-determinants-of-health.pdf Level of MDM (based on 2 of 3 elements of MDM) number and complexity of problems addressed. ACEP: American College of Emergency Physicians – Advancing Emergency Care. ERCODER. Acep.org. Accessed May 9, 2023. https://www.acep.org/siteassets/sites/acep/media/reimbursement/acep---2023-ed-mdm-grid.pdf Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Today Al chats with the co-writers of the OGN, Allincaes: Orphans, Luke Lieberman (Red Sonja) and Ryan Silbert. Tune in to learn all about this new universe and its connection to the legendary, Stan Lee and more… Synopsis – Alliances: Orphans Orphans blasts readers into the heart of our galaxy alongside William Ackerson, a man lost in space on a quest to find the source of his uncanny abilities. As gravity waves ripple across reality, warping time and space, he meets the Orphans. They are each the last of their kind, all their kin having been wiped out by the alien Hive: Little Boy, their giant childlike leader; Haze, a caustic creature of pure vapor; Rascal, a self-loathing zealot with dark secrets; and Critter, a being that's equal parts monster and puppy. This ragtag group find themselves in over their heads when their space-heist is hijacked. They have a stowaway with her own agenda: Samsi, the fearsome survivor of a civilization that once ruled the galaxy. Orphans is a fast-paced, intergalactic treasure hunt that explodes the Alliances universe into the cosmos. It introduces an extraordinary band of lone survivors, that must become a family to save the very fabric of reality. Thank You for Watching / Listening! We appreciate your support! Episode 266 in an unlimited series! Host: Al Mega Follow on: Twitter | Instagram | Facebook): @TheRealAlMega / @ComicCrusaders Make sure to Like/Share/Subscribe if you haven't yet: https://www.youtube.com/c/comiccrusadersworld Twitch: https://www.twitch.tv/comiccrusaders Visit the official Comic Crusaders Comic Book Shop: comiccrusaders.shop Visit the OFFICIAL Comic Crusaders Swag Shop at: comiccrusaders.us Main Site: https://www.comiccrusaders.com/​​​​ Sister Site: http://www.undercovercapes.com​​​​ Pick up official Undercover Capes Podcast Network merchandise exclusively on RedBubble.com: bit.ly/UCPNMerch Streamyard is the platform of choice used by Comic Crusaders and The Undercover Capes Podcast Network to stream! Check out their premium plans for this amazing and versatile tool, sign up now: https://bit.ly/ComicCrusadersStreamyard * Edited/Produced/Directed by Al Mega

Show Notes: Sarah's passion is creative writing and teaching it in ways that inspire and delight others. Today she works as a writing professor at a community college and offers creative writing workshops in hospitals, libraries, alternative education programs and more. Yet Sarah considers her real work to be caring for her three children and their rural homestead through the various challenges and opportunities that come their way. Sarah Silbert, a member of the Harvard and Radcliffe class of 1992, speaks about her journey since graduating from Harvard. She explained that she had been passionate about two areas while at Harvard - social service and community service, and creative writing. She went on to explain that Harvard ran its own homeless shelter, just two blocks from Adam's House, and that this had been the start of her journey and passion for social service. Since then, she has gone on to work around the country to help those needing shelter and support with a focus on teenage runaways. In the late 90's, she became a professor at a community college where she continues to teach about the importance of civic engagement, community service, and self-awareness where she is able to use her knowledge and experience to help students make a difference in the world.   Inspired by Stories of Runaways Inspired by an anthology of creative writing collected by a reporter tracking teenage runaways, Sarah started teaching creative writing workshops in libraries, hospitals, treatment centers, and other places for troubled youth. The teens in these workshops often wrote about the idea of home, and always linked it with a yearning for belonging. Sarah's work with them over led her to reflect on her own desire for a home and to ask herself what “belonging” might mean to her.” Eventually, she realized that she wanted to live in a countryside setting and decided to pursue that goal. Building a Cabin in Vermont She applied for a series of creative writing fellowships which allowed her to stay in cabins in various locations. During her stay in the MacDowell cabin, which was once occupied by James Baldwin, she was inspired to find her own land and build a cabin. She took a house building course in Maine and looked for land in Wyoming and Eastern Washington. She wanted to create a space for young people who didn't have access to artist colonies. She was living out her teenage dream of building a cabin in Vermont. She had been given the land at a rock bottom price, but it had no water, power or road. Then, the electrical company offered her a large sum of money to put a power line across her property, which gave her the power she needed.    Coping with Illness and Grief Unfortunately, her boyfriend was diagnosed with leukemia, and they were in and out of hospitals for seven years. She was 25 or 26 at the time and had to give up her dreams of family and children to take care of him. Sarah felt a spiritual calling to be in this situation, spending many days in the hospital sleeping in a cot by his bed. Despite the hardship, it was an experience that she believes brought her closer to Jeff and taught her to appreciate life. To cope with the grief of Jeff passing,  Sarah decided to jump into a new idea of life and family. She took a year off from college to work for Mother Teresa, which she believes helped her get through the tough time.    Building a Village A few years later she was hired as a teacher at a community college, and started taking in tenants to help with the house and kids. Eventually, her tenants became her fairy godmothers, helping with the house and kids, and her neighbors and godparent also came in to help. Now, six years later, Sarah and her kids are living for their dreams. Sarah Silbert  has traveled the world and seen many different kinds of families. She has found a way to raise her three children without a spouse, but still loves having another adult around to help her with her children. To her, family means having both mom, dad and kids, but she also has a tribe of people who love and support her and her children. She is proud of her physical strength and her mental strength, which she is developing further in a leadership program. The program's motto is “how to be an island of calm in a storm”, which she applies to her own life and the lives of those around her. Harvard courses and professors who influenced Sarah include Susan Dodd, creative writing instructor, and Ed Cohen, founder of The Echoing Green Fellowship.   Timestamps: 12:20: The hardships of living off grid 17:41 Caring for a Loved One with Leukemia  22:42 The Meaning of Family and Personal Accomplishments  26:13: The dynamic tribe 32:30 Combining Physical Endurance with Mental Clarity and Stewarding Kids in Unforeseen Craziness 34:48 Taking a Year Off to Work with Mother Teresa  41:17 Exploring Adventure and Opportunity  Links: https://echoinggreen.org/ “The River We Call Ourselves” in the Sun “Fighting in the Zendo”in the Sun “The Land” in Ploughshares CONTACT INFO: https://www.linkedin.com/in/sarah-silbert-97909111/  

Coach and Eddie Garrison kick off the show by talking to Paul Condry who covered several games tonight including Bethel. Brian Sullivan joins the show to talk about Corydon's 63-54 win over Scottsburg for WNAS. Keith Myers join the show to talk about Mt. Vernon's 53 36 win over New Palestine. Brad Silbert joins to talk about Fishers' 58-54 win over Hamilton Southeastern.See omnystudio.com/listener for privacy information.

It's the start of hour number two here on Network Indiana's Indiana Sports Talk, and Coach Bob Lovell and Brendan King are joined by John Herrick from the IU Radio Network. John joins Coach in talking the big story of the historic rivalry that is IU and Purdue, and what to expect in tomorrow's firework matchup of two of the best teams in the country. Next on IST, Coach Mike Armstrong from Franklin Community joins the show to talk the Grizzly Cub's win over Whiteland 66-43 in the girl's sectional tonight. Next, Brian Sullivan from WNAS New Albany joins Coach to talks couple games from the 2A sectional, first Brownstown 30-28 winners over Providence, and secondly, Austin gets a 54-49 win over South Western of Hanover. The Commissioner of the IHSAA, Paul Neidig joins IST to talk with Coach for a few minutes about what this week of girl's sectional basketball means for the State of Indiana. The calls continue to flow in, joining the show next is David Eha with Ball State Radio to talk an exciting game today for the Cardinals coming away with a 91-90 win in Overtime over Eastern Michigan. Next up, Walt Ferber from WITZ Radio talks Wood Memorial getting a 37-35 win over Northeast Dubois. After that to close the 10 o'clock hour here on IST, Brad Silbert from Hamilton County Television has a couple games from Sectional 8. First, an amazing game where Noblesville has a 67-64 win in double overtime over Fishers. The second game was Hamilton Southeastern coming out on top with a 46-42 win over Zionsville. See omnystudio.com/listener for privacy information.

20230123 - Catching The Crypto Wave With INX & Alan Silbert by Kevin McCullough Radio

In this week's episode of Fostering Change, Rob Scheer talks with Dave Silbert, Co-Founder & Executive Director of So What Else. For as long as he can remember, Dave has always wanted to help people and serve his community in whatever way he could. As a young adult, Dave gained extensive experience working with people as the Assistant Director of an in-patient rehabilitation facility in California. After returning to the East Coast, he started his own personal training and sports coaching business, learning the in's and out's of running one's own business and the joy in working with kids.In 2009, a life-changing service trip to the lower 9th Ward in New Orleans changed the course of his life, and the emotional impact of taking part in this kind of philanthropic activism inspired him and Bob to organize their own community's efforts in a local nonprofit to stimulate volunteerism in their own community; from this simple trip, So What Else was born. Dave has four kids and lives in Montgomery County, Maryland.Story Key Notes:

The Securities and Exchange Commission today charged Genesis Global Capital, LLC and Gemini Trust Company, LLC for the unregistered offer and sale of securities to retail investors through the Gemini Earn crypto asset lending program. Notably, this action comes at the peak of Gemini and Genesis' public fallout. The commission has reportedly been investigating lending offerings since early 2022. Moreover, the focus, then too, was on whether or not these offerings can be considered securities offerings.~This episode is sponsored by iTrust Capital~iTrustCapital | Get $100 Funding Reward + No Monthly Fees when you sign up using our custom link! ➜ https://bit.ly/iTrustPaul

New El Salvador law passed, allowing for Bitcoin Volcano bonds to be created while simultaneously labeling altcoins as securities. Nigeria declares war on cash, Silbert accused of fraud and MUCH MORE on today's show!

Crypto 2023 – like Crypto 2022, but angrier. This week, Gemini co-CEO Cameron Winklevoss accused Genesis, DCG and DCG CEO Barry Silbert of fraud in a major escalation of their fight over frozen funds. Silbert and DCG, CoinDesk's parent, responded with their own letter and Q&A arguing that Genesis and DCG are fundamentally different entities. NLW covers the war of words and the community's response to it.  - Join the most important conversation in crypto and Web3 at Consensus 2023, happening April 26–28 in Austin, Texas. Come and immerse yourself in all that Web3, crypto, blockchain and the metaverse have to offer. Use code BREAKDOWN to get 15% off your pass. Visit consensus.coindesk.com. - “The Breakdown” is written, produced by and features Nathaniel Whittemore aka NLW, with editing by Rob Mitchell and research by Scott Hill. Jared Schwartz is our executive producer and our theme music is “Countdown” by Neon Beach. Music behind our sponsor today is “Swoon” by Falls. Image credit: rudall30/Getty Images, modified by CoinDesk. Join the discussion at discord.gg/VrKRrfKCz8.

Vorige week hadden we het over de open brief die Cameron Winklevoss (CEO Gemini) stuurde naar Barry Silbert (CEO DCG). Die brief heeft blijkbaar niet genoeg impact gemaakt, want Cameron stuurde deze week nog een brief. In deze brief was hij nog bozer dan in de vorige. Bitvavo is, net als Gemini, een schuldeiser van Genesis. Ook bij het Nederlandse bedrijf kwam deze week een update naar buiten over de status van de zaak. We bespreken nog wat andere brokstukken (FTX hearing, Coinbase ontslagen, Binance en Voyager) voordat we overgaan op iets leukers: bitcoin mining in Afrika. Het FD (ja, echt) had deze week een erg interessant artikel over het gebruik van micro-waterkrachtcentrales om bitcoin te minen in Kenia. Satoshi Radio wordt mede mogelijk gemaakt door: Anycoin Direct, Bitvavo, Watson Law, Litebit, Coinmerce, BLOX en BTC Direct (00:00:00) - Opening (00:04:00) - Hoe was de week (00:15:00) - Marktupdate (01:00:00) - De polemiek tussen Silbert en Winklevoss (01:19:00) - Bitvavo update (01:22:00) - FTX bankruptcy hearing (01:40:00) - Bitcoin minen in Kenia (02:06:34) - Afsluiting

In his second open letter in as many weeks, Gemini Co-CEO Cameron Winklevoss ratchets up the rhetoric. Crypto 2023 – like Crypto 2022, but angrier. This week, Gemini co-CEO Cameron Winklevoss accused Genesis, DCG and DCG CEO Barry Silbert of fraud in a major escalation of their fight over frozen funds. Silbert and DCG, CoinDesk's parent, responded with their own letter and Q&A arguing that Genesis and DCG are fundamentally different entities. NLW covers the war of words and the community's response to it. -Join the most important conversation in crypto and Web3 at Consensus 2023, happening April 26–28 in Austin, Texas. Come and immerse yourself in all that Web3, crypto, blockchain and the metaverse have to offer. Use code BREAKDOWN to get 15% off your pass. Visit consensus.coindesk.com.-“The Breakdown” is written, produced by and features Nathaniel Whittemore aka NLW, with editing by Rob Mitchell and research by Scott Hill. Jared Schwartz is our executive producer and our theme music is “Countdown” by Neon Beach. Music behind our sponsor today is “Swoon” by Falls. Image credit: rudall30/Getty Images, modified by CoinDesk. Join the discussion at discord.gg/VrKRrfKCz8.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week, Eoin Fitzgerald and Pete Townsend riff on the latest on Sam Bankman-Fried, dive into fintech and web3 predictions for 2023, and then they do an experimental walk-through of the AI bot ChatGPT. They finish up with a look at some of the January leadership changes in fintech and crypto and an update on the Techstars Web3 accelerator. This episode of MoneyNeverSleeps is sponsored by SecuriCentrix. SecuriCentrix is a trusted cyber security company with offices in Dublin, Cape Town and London. SecuriCentrix provides expert advisory services, primarily in the finance and fintech industries, with tailored security solutions to fit your specific needs and regulatory challenges. STORIES COVERED Sam Bankman-Fried's Lawyers Ask Court to Conceal Identities of $250M Bail Co-Signers (CoinDesk, 3-Jan-23) Is Binance in Trouble? (Forbes, 14-Dec-22) Gemini's Winklevoss accuses crypto mogul Silbert of ‘bad faith stalling tactics' over frozen funds (CNBC, 4-Jan-23) What's in store for European fintech and predictions for 2023? (Sifted, 3-Jan-23) Web3 predictions in 2023 (Life in Color Blog, 2-Jan-23) This is what the future holds for cryptocurrencies (World Economic Forum Davos blog, 2-Jan-23) In a banking industry first, neobank Cogni adds noncustodial Web3 wallet (Yahoo Finance, 22-Dec-22) ChatGPT is Coming for Crypto (Forbes (via CoinDesk) paywalled, 28-Dec-22) Goldman Sachs' consumer banking unit head steps down (Reuters, 3-Jan-23) Zodia Custody Appoints Crypto Exchange Bitstamp's Julian Sawyer as CEO (CoinDesk, 3-Jan-23) Techstars Web3 accelerator investment thesis 2.0 (Techstars Newsroom, 26-Nov-22) LINKS Leave a review and subscribe on Apple Podcasts | Spotify Check out our MoneyNeverSleeps website and get in touch via info@moneyneversleeps.ie Follow us on Twitter: MoneyNeverSleeps | Eoin Fitzgerald | Pete Townsend

This week, Eoin Fitzgerald and Pete Townsend riff on the latest on Sam Bankman-Fried before diving into a few of the fintech and web3 predictions for 2023 published recently, then we do an experimental walk-through of the AI bot ChatGPT. We finish up with a look at some of the January leadership changes in fintech and crypto and an update on the Techstars Web3 accelerator. This episode of MoneyNeverSleeps is sponsored by SecuriCentrix. SecuriCentrix is a trusted cyber security company with offices in Dublin, Cape Town and London. SecuriCentrix provides expert advisory services, primarily in the finance and fintech industries, with tailored security solutions to fit your specific needs and regulatory challenges. STORIES COVERED What's in store for European fintech in 2023? (Sifted, 3-Jan-23) Web3 in 2023 (Life in Color Blog, 2-Jan-23) Is Binance in Trouble? (Forbes, 14-Dec-22) Gemini's Winklevoss accuses crypto mogul Silbert of ‘bad faith stalling tactics' over frozen funds (CNBC, 4-Jan-23) This is what the future holds for cryptocurrencies (World Economic Forum Davos blog, 2-Jan-23) In a banking industry first, neobank Cogni adds noncustodial Web3 wallet (Yahoo Finance, 22-Dec-22) ChatGPT is Coming for Crypto (Forbes (via CoinDesk), 28-Dec-22) Goldman Sachs' consumer banking unit head steps down (Reuters, 3-Jan-23) Zodia Custody Appoints Crypto Exchange Bitstamp's Julian Sawyer as CEO (CoinDesk, 3-Jan-23) Techstars Web3 accelerator investment thesis 2.0 (Techstars Newsroom, 26-Nov-22) LINKS Leave a review and subscribe on Apple Podcasts | Spotify Check out our MoneyNeverSleeps website and email us at info@moneyneversleeps.ie Follow us on Twitter: MoneyNeverSleeps | Eoin Fitzgerald | Pete Townsend --- Support this podcast: https://anchor.fm/moneyneversleeps/support

This week on The Marvelists, we are joined with Luke Lieberman and Ryan Silbert as we talk about their brand new graphic novel, Alliances: Orphans. We talk to Luke and Ryan about the creation of the project as well as the involvement of the Man - Stan Lee! Follow The Marvelists on social media: Twitter/Instagram: @TheMarvelists Subscribe to The Marvelists on YouTube: https://www.youtube.com/channel/UCGe72jbm8J5IXsINZvrJAhg Support the show on Patreon: http://www.Patreon.com/themarvelists Buy our t-shirt: http://www.belowthecollar.com/themarvelists

Het drama rond Genesis en de Digital Currency Group (DCG) duurt voort. Nu hebben de broertjes Winklevoss, bekend van cryptobeurs Gemini, een open brief gestuurd aan Barry Silbert, directeur van DCG. Cameron Winklevoss spreekt in de brief van een gat van 1,6 miljard dollar, waarbij Genesis in gebreke is. Moederbedrijf DCG zou dat geld namelijk oneigenlijk gebruikt hebben. Silbert blijft ontkennen. En dit heeft natuurlijk ook weer gevolgen voor de Nederlandse exchange Bitvavo.  Deze week in de Cryptocast Een gesprek met Marnix Schoorel, oprichter van de podcast Beginnen met Bitcoin en Znip. Dat laatste bedrijf helpt klanten met het opzetten van hun eigen bitcoinopslag. Dat is wel zo handig, in tijden van FTX en Celsius. Co-host is Krijn Soeteman.  Links De open brief van Cameron Winklevoss Statement van Bitvavo over de DCG-situatie Core Scientific en Celsius in de clinch Een beschouwing van proof of reserves Met Herbert Blankesteijn bespreken we elke week de toestand van de crypto. Luister live donderdagochtend rond 9:20 in De Ochtendspits, of wanneer je wilt via bnr.nl/podcast/cryptocastSee omnystudio.com/listener for privacy information.

Mike Broomhead spoke to Col. Silbert about retiring from his DPS Director role.See omnystudio.com/listener for privacy information.

Today's blockchain and cryptocurrency news Bitcoin is up slightly at $16,723 Ethereum is up .5% at $1,216 Binance Coin is down .5% at $245 Pax Dollar, up 16% Bahamas SEC claps back at new FTX Execs. Winklevoss & Silbert feud hits Twitter. SushiSwap to sunset Kashi & Miso Zodia Custody appoints Julian Sawyer to CEO spot. Learn more about your ad choices. Visit megaphone.fm/adchoices

Andrea Silbert's longtime mission has been to advance gender equity and women's economic prosperity. That explains, in part, why Silbert, president of the EoS Foundation, has been named a 2022 Power 50 Movement Maker by the Boston Business Journal, her second time on the BBJ's list of distinguished recipients. Silbert launched her professional life in the field of finance after earning a degree from Harvard Business School. Still, Silbert says, “civil service was a big part of my upbringing.”In this episode of C-Speak, Silbert shares more about her “circuitous” career journey, the “feminization of poverty” she witnessed while traveling throughout Latin America, the opening of the Center for Women in Enterprise (she calls it her best professional moment) and her dedication to a life of service. Powered by PNC Bank.Subscribe to C-Speak so you never miss an episode. Click here to listen on iTunes, Spotify and Stitcher.Download a transcript of the podcast.

Stan Lee's 100th birthday is next month, and we're getting a jump on the celebrations. Joining us on the show this week are comic creators Luke Lieberman, Ryan Silbert, and Bill Sienkiewicz, discussing their collaboration on Alliances: Orphans. The new graphic novel from Dynamite Entertainment springs from Lee's imagination and is further shaped into reality by Lieberman and Silbert. The comic is a cosmic adventure following the Orphans, a ragtag band of desperados who found each other after the alien Hive eradicated their families. After rescuing an earthling named William Ackerson, they discover an equally bizarre and unique stowaway. Together, these heroes challenge the universe and, in the process, save it from blinking out of existence. Alliances: Orphans recalls the grand ideas and characters that shaped the Marvel Universe while never falling into poisonous nostalgia. Lieberman, Silbert, and Sienkiewicz (with additional artist Szymon Kudranski) are extremely aware of the legacy they're shepherding. They want to live up to Stan Lee's mythology, and part of that is knowing when not to be precious. They'll kill an idea as quickly as they come up with it. They learned from the best. We begin our conversation with these artists by celebrating Stan Lee. From there, we dig into their collaboration's early days and how Alliances: Orphans is unlike any other project they've worked on. We get philosophical; we get vulnerable. It's a proper Comic Book Couples Counseling session. Alliances: Orphans is currently available from Dynamite Entertainment. You can find Luke Lieberman on Twitter and Instagram. You can find Ryan Silbert on Twitter, Instagram, and the Origin Story Website. You can find Bill Sienkiewicz on Twitter, Instagram, and his Website. Don't forget! We're screening Howard the Duck on the big screen at the Alamo Drafthouse in Winchester, Virginia. Done in collaboration with the Four Color Fantasies comic book shop. Get your tickets HERE. And, of course, follow Comic Book Couples Counseling on Facebook, on Instagram, and on Twitter @CBCCPodcast, and you can follow hosts Brad Gullickson @MouthDork & Lisa Gullickson @sidewalksiren. Send us your Words of Affirmation by leaving us a 5-Star Review on Apple Podcasts. SUPPORT THE PODCAST BY JOINING OUR PATREON COMMUNITY. Continue your conversation with CBCC by hopping over to our website where we have reviews, essays, and numerous interviews with comic book creators. Podcast logo by Aaron Prescott @acoolhandfluke, podcast banner art by @Karen_XmenFan.

Pub Date is a podcast dedicated to the love of books, and the authors who bring them into the world! In today's episode, Copper Director of Communications, Alex Hudgens, sits down with our first graphic novel creators on the show– Ryan Silbert and Luke Lieberman! Buckle up, because you're in for a fun ride. From the mind of legendary comics creator Stan Lee, the architect of the Marvel Universe, comes Alliances: Orphans, a brand-new original graphic novel set in the New York Times best-selling Alliances universe, co-written by Lee with Luke Lieberman (Red Sonja) and Ryan Silbert (The Coldest Case). Orphans is a fast-paced adventure, and a moving story of found-family that explodes onto the page through brilliant images and the sharp, smart writing that we've grown accustomed to when it comes to the Marvel universe. Listen in to hear Luke and Ryan talk about the writing process when there are multiple collaborators, working with Stan Lee, and how to find the best creative partners for your project. This dynamic duo also dives into the work ethic required to become an ‘overnight success' and how that notion has played out in their careers. Today's episode is certainly for you if you're an aspiring graphic novelist, but there are so many nuggets of wisdom in this conversation for any aspiring author! Marvel fans will enjoy hearing about working with the legendary Stan Lee, especially since Luke and Ryan give us an insider's peek into his creative process. This conversation will also inspire and encourage you to get into community as you create, and remind you that you're never alone. You can get your copy of Ryan and Luke's new book here, and you can connect with Luke and Ryan @alliancesuniverse on Instagram. Learn more about Copper Books by clicking here, and follow @copper.books and your hosts @alliebridge and @a_hudge on Instagram!

Earl Silbert was known for his role as the first prosecutor in Watergate and he served as President of the College from 2000 to 2001. Host Dave Paul talks with Earl about the Watergate “scandal” and his extraordinary career in private practice.

Today's guests are Alan Silbert, North America CEO of INX, and Itai Avneri, COO of INX. INX aims to offer a fully-licensed and regulated cryptocurrency, security token, and derivatives trading platform. They also endeavor to be a leader in the regulated security token platform space. INX announced in January 2018 its submission of a confidentially-filed draft registration statement to the US Securities and Exchange Commission (SEC) for an initial public offering of the INX Token. INX is one of the leading platforms from a regulatory and compliance perspective; they are a broker-dealer, have various alternative trading system licenses, and a cash fund to safeguard platform capital. Alan Silbert, CEO North America of INX. He joined the Company in March 2018 as Executive Managing Director. Since joining INX, Alan has been responsible for facilitating the build-out of the director and advisor team, raising capital, growing operations and infrastructure for North American operations, and leading the regulatory processes for broker-dealers and money transmitter licenses. Alan's career in finance spans almost 25 years, where he has held executive positions in various large banks. He also founded, in 2013, Bitcoin luxury marketplace BitPremier, which in 2014 brokered one of the first bitcoin real estate transactions in history. Itai has launched multiple financial services and products in Europe and South Africa, among other regulated jurisdictions. He designed and built advanced information systems specializing in trading, BI & CRM solutions, marketing, KYC automation, and payments and integration hubs. We discuss various topics, including INX, Security Tokens, Regulation, and much more. We began our conversation by discussing how INX started and how the organization has been leading the charge in pushing regulation forward and regulatory clarity since the company's inception. Alan and Itai describe the current state of the INX platform and the various functionalities open to accredited investors. Our following conversation topic centers around the benefits of security tokens and why security tokens will revolutionize how capital markets are structured. We discuss the views of various regulatory jurisdictions on digital assets. We discuss how regulators could distinguish between security tokens and cryptocurrencies. We discuss the crypto industry's positive progress within American society from a regulatory and cultural perspective. Our final discussion topic centered around how INX is helping companies navigate the regulatory waters by advising them and publishing a book that will share the best practices for navigating the regulatory hurdles that crypto companies face. Please enjoy my conversation with Alan Silbert and Itai Avneri. -- SafePal is a Singapore-based Binance labs backed company that provides secure and easy-to-use wallet solutions for the crypto masses. With the mission to make crypto secure and simple for everyone, SafePal has built comprehensive crypto asset management solutions, including hardware wallet, mobile wallet, extension wallet, cross-chain swap, trading service, and more. SafePal has supports 48 blockchains and 15 languages, and serves more than 6 million users global-wide. Use code charlie for 10% off SafePal's S1 wallet at https://store.safepal.io/safepal-s1-h... Download the SafePal App and SafePal extension wallet at https://untoldstories.link/safepal -- This podcast is powered by Blockworks. For exclusive content and events that provide insights into the crypto and blockchain space, visit them at https://blockworks.co

There's more to life than your job.  It's something people say, but don't really internalize until tragedy or crisis strikes.  What if we could reach that realization, sans crisis?  Jen's on a mission to get women off the hamster wheel and into a life that lights their soul.Jen Silbert is sharing her wisdom as a life coach, confidence coach and all around adventure seeking bad ass.  It was a lot of fun to hear the back story of my internet friend and her army counter intelligence that I had no clue about.In this episode, we chat about:1. Learning to celebrate our achievements and ourselves.2. Recognizing our conditioning3.  Creating a life for yourself outside your job.Go here for full show notes and links!Resources:  Want to know 7 things you can do today to make leaving corporate easier?  Grab it here! Follow me on:InstagramWebsite LinkedIn Twitter YouTube Loved this episode?

Col. Silbert talked about the uptick in violence against law enforcement & his meeting with Governor Ducey about what's happening at the border.  See omnystudio.com/listener for privacy information.

Tim Slocum joins us to talk about his paper, Features of Direct Instruction: Content Analysis Show Notes Remember to join us on Facebook to suggest articles to review and questions for authors. https://www.facebook.com/BApractice Acknowledgments Host and Executive Producer: Cody Morris, Ph.D., BCBA-D, LBA https://salve.edu/users/dr-cody-morris Assistant Producers Elizabeth Narvaez Jesse Perrin Production Assistants for this Episode Chloe Calkins Organizational Support ABAI https://www.abainternational.org/welcome.aspx Behavior Analysis in Practice Editor, Stephanie Peterson, Ph.D., BCBA-D, LBA https://www.abainternational.org/journals/bap.aspx Music Cruising Altitude by Jim Carr and his band New Latitude http://www.newlatitudemusic.com Link to Article https://link.springer.com/article/10.1007/s40617-021-00617-0 Links from Talk Morningside https://morningsideacademy.org/ BAP Special Issue: Direct Instruction https://link.springer.com/journal/40617/volumes-and-issues/14-3 Story Champs https://www.languagedynamicsgroup.com/story-champs-2/story-champs-about/ References Carnine, D. W., Silbert, J., Kame'eanui, E. J., Slocum, T. A., & Travers, P. A. (2016). Direct Instruction Reading (6th Edition). Pearson Education. https://www.pearson.com/us/higher-education/program/Carnine-Direct-Instruction-Reading-Enhanced-Pearson-e-Text-Access-Card-6th-Edition/PGM2490335.html Stein, M., Kinder, D., Silbert, J., Carnine, D. W., & Rolf, K. (2017). Direct Instruction Mathematics (5th Edition). Pearson Education. https://www.pearson.com/store/p/direct-instruction-mathematics/P100000110708/9780134711225?creative=544666367026&keyword=&matchtype=&network=u&device=c&gclid=Cj0KCQjw5-WRBhCKARIsAAId9FnUH_nNQTVO3EuGmojnQNz3Wf7r8Ax_fM5GPlmr0UZ3ALJXxI_VuVEaApllEALw_wcB&gclsrc=aw.ds Engelmann, S., & Carnine, D. (2017). Theory of Instruction: Principles and Applications. NFDI Press. https://www.researchgate.net/publication/303721842_Theory_of_Instruction_Principles_and_Applications

Andrea Silbert, President at Eos Foundation, speaks with CEO Bonnie Hagemann about her life and career journey. Andrea shares insight into how she got where she is today as a female executive. You do not want to miss her story. Please make sure to like, rate and subscribe to the Real Life Real Leaders podcast.

Hey friends!  In this episode, I did something a little bit different. I actually did a live podcast over on my Instagram, @JamieRiene  and I think it's gonna be something that I might try going forward.  It was actually kind of fun, it was a way for me to step outside of my comfort zone, which as you will hear in this episode, my new motto is basically just to run towards the fear because that is where my edges are. And I am all about growth in this season, and this was an interesting conversation, my friend Jen Silbert, was able to hop on, and we really just had a conversation about the various ways that we have made money, and people are making money online, and kind of what is out there. Not only that but really what it takes to make money whenever you leave corporate and put yourself out there because it's not necessarily what you think there's a whole lot of mental ninja shit that you're gonna have to overcome. And so this is just a real honest conversation about some of those things. To learn more about Jen you can go to her website or on Instagram @JenSilbertCoaching.  Please take a screenshot of this episode and tag us over on Instagram and help spread the word.  Resources:  Want to know 7 things you can do today to make leaving corporate easier?  Grab it here! Let's connect!  Come join the Breaking Up with Corporate Facebook Community

“Everybody needs a passion. That's what keeps life interesting. If you live without passion, you can go through life without leaving any footprints.” (Betty White) Do you know what your passion is? Today we are talking with Andrea Silbert, President of the Eos Foundation. Andrea has been a mentor of mine for over 18 years. I was drawn to her because of her mission to support women. When we met, she was the CEO of the Center for Women Enterprise and also the mama of 3 kids. Andrea went to Harvard for both undergrad and business school and had a career in banking, then moved to non-profit. To create change on the policy level, she ran for Lieutenant Governor of Massachusetts. Today, she is the President of the Eos Foundation, where they are doing research on the power gap and glass ceiling that still exists today. Throughout the years, I've asked her a lot of advice - on how to choose career paths, how to lead as a woman, and most definitely how to balance work and life.  In Boss Mamas, we talk about the importance of leaning into your own power, believing in yourself, and not letting others hold you back. Andrea is a great example of finding her passion and going for it. She also shares the importance of finding the right partner and that both parties should have a fulfilling career outside of the home. Get full show notes and more information here: https://analizawolf.com/ep-21-find-your-passion-with-andrea-silbert    

On this week's live show, guests Max Allan Collins ("Fancy Anders Goes to War," "Road to Perdition") + Ryan Silbert and Luke Lieberman ("Stan Lee's Alliance: A New Reality")! SUBSCRIBE ON RSS, ITUNES, ANDROID, SPOTIFY, STITCHER OR THE APP OF YOUR CHOICE. FOLLOW US ON TWITTER, INSTAGRAM AND FACEBOOK. SUPPORT OUR SHOWS ON PATREON. Don't forget to go to https://www.Manscaped.com and use the promo code FANSIDED20 to get 20% OFF YOUR ORDER AND FREE SHIPPING! Support the show: https://www.patreon.com/comicbookclub See omnystudio.com/listener for privacy information.

Location: Squadcast Date: Monday 31st August Company: INX, Casa, Blockstream Role: Executive Managing Director, CTO, Chief Strategy Officer Last week INX launched their token offering, a first of its kind,  a security token approved by the US Securities and Exchange Commission.  INX is a trading platform bringing regulated and digital asset opportunities to institutions and retail investors. Their token offering allows investors to gain pro rata distributions from the companies cumulative adjusted operating cash flow. Controversially the token was launched on the Ethereum blockchain. The project already has its detractors and critics, with the advisory board catching direct criticism with accusations of hypocrisy, specifically Jameson Lopp and Samson Mow. While many Bitcoiners have expressed their opinions against the project, others have thrown their support behind it, believing that INX is a legitimate use of a token. In this interview, I talk to Alan Silbert, Jameson Lopp and Samson Mow about the launch of INX. We discuss why they chose to tokenise on Ethereum, what makes something a shitcoin and the key criticisms directed towards them.