Podcasts about Refresh

Introducing Instagram's Visual Refresh (Instagram Blog) How To Turn Captions On and Off in Instagram (The Verge) The Instagram Stories is sponsored by Hashtag Slayer! Register at HashtagSlayer.com and use code IGStories for a free month. Want to support the show? Buy Me a Coffee Leave a Review: Apple Podcasts --- Send in a voice message: https://anchor.fm/danielhillmedia/message

wikifoliotrader Marco Schai setzt in seinem Wikifolio Refresh auf Geschwindigkeit und auf Sondersituationen. Anlagehorizont ist oft kurz bis sehr kurz. ( https://go.brn-ag.de/140 ) Die Performance allerdings seit Start im Sommer 2018 - so gut wie nichts mehr. Das ist insofern bitter, denn die Performance stand im November 2021 noch bei knackigen 50 %. "Da kamen zwei Dinge zusammen: Der Markt war schwach und die Techwerte durch Lieferketten und Zinsthematik gebeutelt. Da konnte ich mich nicht entziehen. Aber ich denke, dass wir den Boden erreicht haben." Momentan ist Marco wieder voll investiert. "Es ist nicht mein Job Cash zu halten, das kann man auch auf der Bank machen." Besprochene Aktien unter anderem. Tonie (da gibt es offensichtlich einen Markt!), Fiverr (unterbewertet), All4One, DFV,...

I neglected to mention the significance of 4-20 so please forgive me. I DO share a Doobie with you. Isn't that worth something? This time I also share the electric violin of Jean Luc Ponty, Doobies and Little River Band from my LPs and more. How about the 23rd love letter from a 17 year old, in song? Spooky Tooth is here too. Spring is in full bloom now. Suddenly, the leaves have popped out on our maples and it's all so green! Be sure to vote May 3rd! Coming up Wednesday the 27th at 5 central time on RadioFreeNashville.org and at 103.7 and 107.1 in Nashville, Tales Vinyl Tells plays Badfinger, Peace and Quiet (they're NOT), Mose Allison, Jimmie Spheeris and a few more. Refresh your memory and your senses when you join me! And please consider donating to community radio with money or even your old auto. Check RadioFreeNashville. Thanks!

Are sales hard for you as you're trying to start a business? Maybe you feel weird selling things in general or maybe you just don't know how to authentically sell the products you know others will benefit from. You have this business idea and want it to be successful, but where and how to sell your products seems to the thing that's getting in the way and keeping you from success in your business. Well today, we're talking all about sales. In this interview, you'll be hearing the conversation I had eith Ashley Meyer from the MOMpire Network.  She has a heart for moms and helping them run successful businesses - online and off. In this episode, you'll hear us talk about:  Creating authentic relationships to build a network  How moms can support other moms growing businesses while they grow their own How referrals can be a game changer in your business  And more!  More about Ashley Meyer As an attorney, wife, mom of 3, law firm owner, MOMpire founder, and serial entrepreneur, Ashley's passion in life is showing other moms that they can build a business they love without sacrificing themselves or their family.  She started MOMpire on a whim when she was kicked out of a Mom Facebook group because business didn't belong there. She knew there were other moms who longed to love motherhood, but still do business. She created a home for moms to build deep connections, true friendships, and authentic referral partnerships, leading to profitability without exhaustion. Ashley truly believes that community is the best, most sustainable way to grow a business that you love while supporting the life you dream about.   Instagram: https://www.instagram.com/themompire/ Website: http://themompire.com/ Email: hello@the-mompire.com Get a 30 Day free trial to the MOMpire Network here: https://joinmompire.com/   How to Enter the Refresh and Recharge Mom giveaway (includes a copy of Mom You're Amazing by Sandy Cooper, a lovely prayer journal, and Panera gift card): Leave a review on Apple Podcasts about the show. Take a screenshot before hitting submit and then send that to me either on Instagram @mamawithacalling or via email at alexia@mamawithacalling.com .   If you're already left a review before, then send me a screenshot so I'll know you want to enter this drawing.  For an extra entry, share your favorite episode, something you like about the Mama With A Calling podcast, etc. in your stories and tag me @mamawithacalling (If you don't tag me, I won't see it so it won't count) That's it!  Enter by May 27, 2022 to be eligible. (No purchase necessary to enter or win.)

Chriselle Lim is a fashion stylist, content creator, and entrepreneur—and she's here to help us all get out of our collective post-pandemic fashion and beauty rut. She's also the force behind spring's blockbuster fragrance hit: Phlur Missing Person. We discuss how she became the owner and creative director of Phlur; the evolution of fashion and beauty content online; how her divorce inspired Missing Person (and caused her to change her own style); her best fashion and beauty tips; and products she's obsessed with—including the $25 hot tool she uses to style her signature bob.Shop the products mentioned on Ep. 405: shopmyshelf.us/collections/51026Episode recap, links, and sponsor promo codes: fatmascara.com/blogPrivate Facebook Group: Fat Mascara Raising a WandSocial media: @fatmascara, @jessicamatlin, @jenn_editSubmit a "Raise A Wand" product recommendation and be featured on the show: email info@fatmascara.com or leave a voicemail at 646-481-8182 See acast.com/privacy for privacy and opt-out information. Become a member at https://plus.acast.com/s/fatmascara.

We're only one weekend away from our big Pan Dulce Life party in San Diego on Memorial Day Weekend, so we're gearing up with a brand new, high-energy episode of the mixshow! As always, hosted by DJ Refresh and Murcielago Mayor.Kicking us off today is resident PDL mixer DJ Zay, who drops 30 minutes of house, guaracha, reggaeton, and more! Zay is a mixer on Fuego 101.9 FM and resident at Faces Nightclub in Sacramento.And keeping our Los Angeles DJ month edition going is special guest mixer, DJ K-Nasty. His set consists of Latin-influenced house music, dembow, and reggaeton. K-Nasty is a resident at Conga Room in LA and at Onyx Nightclub in SD every second Saturday of the month.As always, thank you for your support y Saca Las Conchas! Hit us with a follow and share the show with a friend!Follow Refreshwww.instagram.com/djrefreshsdFollow Murcielagowww.instagram.com/14cabezonFollow Zaywww.instagram.com/djzayFollow K-Nastyhttps://www.instagram.com/djk.nasty See acast.com/privacy for privacy and opt-out information.

En este episodio César Tánchez junto a Mario López conversan sobre la situación macro económica mundial y cómo nos afecta, sino proporcionarnos consejos para afrontarlos de mejor forma en nuestra economía personal. Se parte de nuestra comunidad enviando tu nombre al WhatsApp: https://wa.me/message/PS6UMWDCZBORM1

Welcome to Season 4 of the She Hit Refresh podcast. A podcast for women age 30 and up who want to break free from routine and start a life of travel. Specifically women who want to move abroad or travel the world long-term. I sit down with women who have made their refresh dreams come true and discuss how and why they moved abroad or hit the road to travel. In this episode I speak with Jessica Ellerbrock who is 45 years young and originally from Ohio. Jessica moved up the ranks in retail buying working for large corporations like The Men's Warehouse and Sears but when she was unexpectedly let go after a 10 year run she not only lost her job but also her identity. So she did what any refresher would do in times of uncertainty, she hit the road to travel! Travel has taken Jessica all over the world and has led her to find her purpose and passion. Listen in as Jessica tells us how her road of refreshes led her to London where she currently works as a Sales & Operations Manager for a social enterprise that employs women in creative arts. What we discuss How losing a job in corporate America led to a loss of identity The healing process of Walking the Camino de Santiago Losing her mom at 27 to breast cancer and how (and when) she dealt with the loss How hitting brought awareness to her trauma and allowed her to seek help How a Kiva fellowship to Rwanda in microfinance set her on a whole different path Her subscription box Wanderkarma Doing a masters at age 41 and changing careers How she went to volunteer in Greece at a refugee camp and ended up getting a job in London How she found her passion from her refresh journey What helped keep her moving forward during the uncertainty and more! About Jessica Jessica always had wanderlust, but never had time. At 38 she lost her job in Corporate America and immediately took a refresh backpacking trip through Europe. She spent 2 months in Spain - 1 of those months was spent walking the Camino de Santiago. This journey showed her that she had a lot of work to do on healing from the death of her mother. Since then, the journey continues from volunteering in microfinance in Rwanda, going back for her masters, and to now working with a social enterprise employing refugee women in creative products. Her passion is her own small business - Wanderkarma, which is a subscription travel box supporting local artists in a new country each month. Connect with Jessica on her website, at Wanderkarma, and follow her on Instagram. Looking to move to Europe? Get your copy of I'm Outta Here! An American's Ultimate Visa Guide to Living in Europe. Join our She Hit Refresh Facebook Group, get more tips and advice on how to hit refresh on our blog and follow us on on Instagram and Twitter. Check out our Forbes feature: How Americans Can Move To Europe (It's Easier Than You Think)!

Continuing last week's conversation: if I only have $100 but want to do a living room re-fresh, is it better to save and wait or are there things I can change now within this budget? Part 2...what if my budget was $200? $200...not much more than last week's $100, but definitely an improvement! But when you're wanting BIG CHANGE in your living room and you have a tiny budget to start with, even with an extra $100 to spend it's not going to bring about big change...right? WRONG! In today's episode I share two options for re-freshing your living room with a $200 budget. Option 1: a continuation of what we did for Sarah, last week. If you missed that episode, listen here:  Option 2: spending $200 at once. What are good options for a living room re-fresh when you're working with that budget? * Paint: but you need to start with a color palette (listen here for how to create one) * Lighting: enhance the mood with some ambient lighting and ditch the builder grade overhead light fixtures to bring in lighting with your personality * Small Anchor Pieces: not sure what those are? Go back and listen to the episode where I flip BUDGET on its head, making it not only imaginable but fully possible for you to create a home you love with the budget you have. Listen here. // Links mentioned in show: // * Feeling BRAVE? Post a picture of YOUR living room in the Facebook Community with the caption $200 and I'll suggest budget-friendly change specific to you (*I will do this for the first 5 people who comment with a picture. Offer expires 6/1/2022). https://bit.ly/design101group * Work with me: www.figandfarmathome.com * Email: figandfarmathome@gmail.com   Happy Styling! xo, dani    

Terry is joined by Vicky Deere-Bunnell, Monument Square Districts Board President, to discuss the many exciting renovations in downtown Urbana that will uplift the city's look and feel. tags: MM, terry ceyler, Vicky Deere-Bunnell, urban, renovations, downtown, community, champaign county, refresh, city, history

Sydney Steinaker is an amateur pickleball player with aspirations of going pro, an influencer and is the host of The Basic Dink pickleball-themed podcast. On various social platforms like Instagram and TikTok Sydney comments on and builds awareness for the sport through her journey in the fastest growing sport in North America. Her unique approach to social media and her take on the sport is exposing the sport to a whole new audience and demographic.   In this episode Sydney and Jamie talk about how her online platform is connecting with a younger generation of players and people looking to try the sport, how she is navigating her new-found influence in the sport and how she works to balance her training, tournaments, her job in cyber security and her podcast.  Be sure to tell Sydney and Jamie what you think about this episode by leaving a review and rating.  It helps us get the message out there!                 Refresh and plan!   Find out more   https://linktr.ee/bigideabigmoves             Follow us on Instagram @bigidea_bigmoves          Facebook www.facebook.com/bigideabigmoves               For amazing Lifestyle Clothing epitomesportswear.com Our listeners get 20% off with the code BIBM       For Human Resources and Talent help contact www.epitomeHR.com Take their free assessment            Talk to us about partnerships    https://beacon.by/epitome-hr-inc/bibm-sponsoship-packages        Follow Sydney on IG at @sydneysteinaker  on TikTok @sydneysteinaker YouTube @Sydney Steinaker  

REFRESH es ... La Frescura del Sonido DANCE del Recuerdo...Todo un viaje por las Décadas de los 90s & 2000s. Un Radioshow semanal que se emite TODOS LOS DOMINGOS DE 19 a 21h en LA FRESCA FM. Presentado por todo un Locutor de Éxito ... JAVIER CALVO, te ayudará en éste viaje para que lo único que hagas sea BAILAR y DIVERTIRTE. Si te has perdido alguno de los programas anteriores, visita la web javiercalvodj.es/Refresh-La-Fresca o sigue REFRESH en Spotify y Mixcloud SPOTIFY: open.spotify.com/show/2xQdSVCs...8aead6d25bb4b74 MIXCLOUD:mixcloud.com/javiercalvo_dj

Welcome back, sleepyheads. Tonight, we'll take a peaceful walk through forestry, leading to a beautiful shoreline, all in the company of Jo and her happy pet dog, Charlie.

A refresh of each of the current 7 commits for the 2023 class for the Minnesota Golden Gophers football program. We touch on the strengths of each commit's game as well as who they chose the Gophers over. Where the Gophers football recruiting class stands both nationally and within the Big Ten conference. Plus where the Gophers could realistically finish when it's all said and done. Touching base on how many offers the Gophers have out at each position in the 2023 recruiting class. While discussing the number of offers by position we also bring up some names to watch that seemingly have higher interest in Minnesota. On today's Locked On Golden Gophers, host Kane Rob, former collegiate football video coordinator and recruiting assistant, discusses a quick refresh no the Gophers 2023 recruiting class as it currently stands. Kane then discusses where we rank both nationally and within the Big Ten conference and where we could realistically finish in those areas. Finally we talk about the number of offers extended to each position and which prospects could have a stronger interest in the Gophers Football program. Follow Us: Kane Rob Locked On Golden Gophers   Email: LockedonGoldenGophers@gmail.com   Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Athletic Greens Athletic Greens is going to give you a FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase. All you have to do is visit athleticgreens.com/COLLEGE.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

enjoy the ride

In the first of this two-parter, I invite you into a conversation about becoming or rediscovering hope and eagerness about dating. Join me for this deep dive into how becoming “pro dating” and a pro at dating means could radically shift your perspective on dating and creating long term relationships. Tune in to hear…What it means to be Pro-Relationship rather than Pro-SelfHow to approach dating like you would in a relationshipThe 5 characteristics of “Secure Functioning Dating”Developing a Pre and Pro-Dating MindsetIdeas for meeting dating partners IRL rather than relying solely on appsResourcesCheck out Wired for Dating by Dr. Stan Tatkin for more detail on secure functioning dating. Want to share your thoughts? Have ideas for episodes? Leave a message on the Phone Line at 512.808.0849 .Learn more about me and how I help gay, bi and queer men – and allies too - live, love and lead powerfully by visiting www.buckdodson.com and Gay Men's Life Lab on Facebook. If you found this episode helpful, please ‘gay it forward' by subscribing and leaving a quick review and rating. This helps more gay men find Gay Men's Life Lab! Thanks!Buck

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Josh refreshes his edible water feature.

When in doubt don't throw it out. Refresh, by discarding half of it, and especially any of the smelly, colorful chunks-then just add about the same amount of volume of flour and water. Your starter is stronger than you think, just got to help the good bacteria out by getting rid of the bad bacteria. Happy baking! For more information about House of Bread, please visit www.houseofbread.com. To purchase the House of Bread recipe book, please visit https://houseofbread.com/recipe-book/ To take an on line class, please visit https://houseofbread.com/product-category/online-baking-class/ If you'd like more information about the franchise opportunity with House of Bread, please visit www.houseofbreadfranchise.com. For our Utube channel, please go here https://m.youtube.com/channel/UCXH5NgT8vpnAuSuZN5AxEQQ. --- Send in a voice message: https://anchor.fm/house-of-bread/message

This week Nikki joins us for a Design Refresh! Nikki recently moved into a new home with her family and is looking to spruce up the first room you see when entering the house, which includes her office space. We talk through some of the pieces she wants to put in this space, what's already there, and what else she could add to create a more welcoming and fun environment. Using the principles of Feng Shui, I give her some tips to start improving the space. Featured in this Episode Featured candle: Beeswax candle fromhttps://www.mithrascandle.com/ ( Mithras Candle) Featured brew: https://novakombucha.com/product/pink-guava-mint/ (Nova Kombucha - Guava Mint) Featured deck: https://shop-laluli.com/ (La Flora Tarot) Episode Highlights 03:16 - Card pull from La Flora Tarot 04:41 - What is home for Nikki 05:55 - Nikki tells us about the space she wants to redesign 08:11 - Nikki's vision/inspiration for the space 09:01 - Rachel pulls up photos and gives suggestions for the space 23:15 - Rachel recommends some paces Nikki can shop for some of the suggested items Are you looking for advice on the design of your space? Rachel is hosting Design Refresh episodes on the the podcast. This is perfect if you have that one room that you aren't sure what to use it for or what to do with it. This is your opportunity to get one on one advice from a holistic interior designer. These are booked on a first come first serve basis. You can book your session https://calendly.com/rachellarraine/refresh?month=2022-03 (here). Receive your copy of the first Zine https://www.bewitchingthehome.com/zine (here. ) Connect with Rachel Larraine: https://my.captivate.fm/www.bewitchingthehome.com (Podcast Website) https://www.instagram.com/rachellarraine/ (Instagram) https://www.patreon.com/Bewitching (Patreon) https://my.captivate.fm/www.crawfordpallini.com (Interior Design Website Crawford Pallini)

In 2019, the brand went through TBWA's Chiat Day's “Disruption” planning process, which attempted to realign enterprise-wide activities around a refreshed expression of the brand's platform. This is the strategy story. 

Any SaaS founder can tell you that implementing feature requests can be a major drain on their resources. But they are a great way to nurture your relationship with your users. Jessica will walk you through the build of a feature request (our MicroConf Connect wiki!), how it can be quickly build and deployed, and how you can use the tools to build MVP’s for your most requested features. - https://microconf.squarespace.com/s/MicroConf-Remote-30-building-internal-tools-with-no-code-1.pdf Links from this podcast: Jessica Malnik Get the slide deck Tickets for our next MicroConf Local:London on May 18 are on sale

Pick Another Date #158. Within Brim's Skin -- Brimstone is joined by his wing man Alex DaPonte as they discuss lots of things involving Brim's recent fail of an attempt to get an MRI and the guys bring back the coveted word of the day Brim discusses his distaste for Ready Refresh and explains why they've given him such a bad taste in his mouth. Brim tells Alex all about how he did a couple of his own records and announces a couple of upcoming appearances. Essentially - he explains what gets Within Brim's Skin.

Pick Another Date #158. Within Brim's Skin -- Brimstone is joined by his wing man Alex DaPonte as they discuss lots of things involving Brim's recent fail of an attempt to get an MRI and the guys bring back the coveted word of the day Brim discusses his distaste for Ready Refresh and explains why they've given him such a bad taste in his mouth. Brim tells Alex all about how he did a couple of his own records and announces a couple of upcoming appearances. Essentially - he explains what gets Within Brim's Skin.

This week's episode is dedicated to knowing that everything happens timely with divine precision.   Lauren Wilson is adept at marketing. She is also well-versed in the arts and luxury goods.  Her resume reads like an illustrious fashion and luxury wish list.  She is currently the founder of Dora Maar, a luxury pre-owned resale site.  Prior to becoming her own boss, she was the business development manager at Moda Operandi; a marketing coordinator at Christie's auction house; the Entertainment Industry Relations Assistant at Gucci, a PR associate at Ralph Lauren; an editorial intern at Vogue; a fashion and shopping intern at Elle; and a press office intern at Jimmy Choo. But wait, there's more.       Her formal education took place at the University of Southern CA, NYU, and the University Paris Sorbonne.  She's major.  Brains, beauty, and style.   Catch the latest episode of the Forever F.A.B. podcast on Apple podcasts, Spotify, YouTube, iheartradio, Podbean, and wherever you listen to your favorite podcasts.  For past episodes featuring guest star interviews, beauty product reviews and innovations in plastic surgery, visit ForeverFABpodcast.com.     Dr. Shirley Madhere is a NYC-based plastic surgeon and Founder of Holistic Plastic Surgery.  This philosophy is based on a whole-body, mind, and spirit approach to beauty and incorporates wellness, integrative nutrition, functional aesthetics, and complementary medicine.   Dr. Madhere's approach to optimal outcomes in plastic surgery is through a lens of wellness, and is grounded in science and backed by ivy league medical study, research, and extensive surgical training.  View her menu of services at ElementsandGraces.com.  Consultations are available in-office, virtually, and online via Click-lift.com.   Coming soon: Dr. Madhere offers beauty on call services through Jet Set Beauty Rx, a mobile medical aesthetics unit delivering beauty in the privacy of your own home.  Reserve at JetSetBeautyRx.com.   As a creative outlet and means to broaden the perspective on the “spectrum of beauty,”  Dr. Madhere created Forever F.A.B., a podcast dedicated to Fashion, the Art of living well (i.e., wellness), and all things Beauty.  Visit ForeverFABpodcast.com for past and new episodes.     If you enjoy listening to the Forever F.A.B. podcast, get more audio and visuals with a membership through Patreon.  Choose the Gold, Platinum, or Diamond tier for premium added content, special co-hosts, lifestyle videos, branded merchandise, and private access to Dr. Shirley's Clubhouse by visiting patreon.com/ForeverFAB.   Catch the latest episode of the Forever F.A.B. podcast on Apple podcasts, Spotify, YouTube, iheartradio, Podbean, Amazon podcasts, and wherever you listen to your favorite podcasts.  For past episodes featuring guest star interviews, beauty product reviews and innovations in plastic surgery, visit ForeverFABpodcast.com.   The F.A.B. Five according to Lauren Wilson:  Recommendations/The F.A.B. Five according to Lauren Wilson: Take weekends off. Recommendations/The F.A.B. Five according to Lauren Wilson: Don't take things or yourself so seriously. Recommendations/The F.A.B. Five according to Lauren Wilson: Build your support network. Recommendations/The F.A.B. Five according to Lauren Wilson: “If it's not going to matter in five years, don't spend more than five minutes worrying about it.” (Anon) Recommendations/The F.A.B. Five according to Lauren Wilson: Always have a “lippy;” never leave home without a good lip! If you want to be a Muse, check out the archival luxury fashion at Dora-Maar.com. Also check it out on social: @shopdoramaar. ***** As always, if you liked this episode of the Forever FAB podcast, please share it and subscribe to the feed. Listen to past episodes or check out who's coming up next on foreverfabpodcast.com.   If you enjoy listening to the Forever F.A.B. podcast, get more audio and visuals with a membership through Patreon.  Choose the Gold, Platinum, or Diamond tier for premium added content, special co-hosts, lifestyle videos, branded merchandise, and private access to my Clubhouse by visiting patreon.com/ForeverFAB.   If you are the Founder of or represent a beauty brand and want to be featured on an episode of the Forever FAB podcast segment of Fifteen Minutes of FAB, send me some stuff.  Visit ForeverFABpodcast.com and fill out the Contact form.   For general holistic beauty tips or to set up an appointment with me to discuss your personalized options for leveling up your beauty, go to ElementsandGraces.com and sign up for my newsletter.   And for an online e-consultation on time, anytime and on your time, visit Click-Lift.com for your wellness, plastic surgery, and beauty questions on the go. And… if you don't want to go anywhere or leave your home, look out for Jet Set Beauty Rx offering mobile aesthetic medical services, such as injectable fillers and multi-vitamin facial treatments.  Jet Set Beauty Rx is coming to your neighborhood soon.   Credits: Video backdrop: custom by Anyvoo Fashion: tank top by Ports 1961; jumper by Tracy Reese Beauty: skincare by Wonderskin Purevoc Makeup: n/a   Produced by www.oneofoneproductions.com Recorded, mixed, edited and original music by www.23dbproductions.com   Podcast Medical Disclaimer The purpose of this podcast is to educate and inform. It is no substitute for professional care by your doctor or your own qualified healthcare professional. Never disregard professional medical advice or delay in seeking it because of something you have read on this podcast or in any linked materials. Guests who speak on this podcast express their own opinions, experience and conclusions, and Dr. Shirley Madhere neither endorses nor opposes any particular opinion discussed in this podcast. The views expressed on this podcast have no relation to those of any academic, hospital, practice, institution or other entity with which Dr. Shirley Madhere may be affiliated.

It's a little late but we got one recorded! Bayern Munich have played their penultimate game of the season and the transfer rumors are in full swing. We have news about Serge Gnabry, Noussair Mazraoui, Ryan Gravenberch, and the surprise news that Liverpool's Sadio Mane is Brazzo's dream target for this summer (yeah right). Plenty to talk about, so give it a listen! In this episode, Samrin and INNN discuss: A review of Bayern Munich's draw to Stuttgart, because we couldn't do one on Sunday because of scheduling conflicts. Nagelsmann's reluctance to use younger and fringe players since clinching the title. Why fans should cut Tanguy Nianzou some slack. How Niklas Sule leaving puts Bayern's long term defensive planning into flux. Switching gears to transfers — does the Sadio Mane rumor make any sense? Why it would be better for Nagelsmann to not get any big expensive signings this summer. Parallels between Kovac, Ancelotti, and Nagelsmann. An unscheduled interruption — thanks Zoom! INNN defends Nagelsmann for a second (very rare!). One final announcement for our regular listeners. As always, thanks for your support and let us know what you think! Be sure to stay tuned to Bavarian Podcast Works for all of your up to date coverage on Bayern Munich and Germany. Follow us on Twitter @BavarianFBWorks, @jeffersonfenner, @TheBarrelBlog, @tommyadams71, @bfwinnn, and more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Have you ever found yourself just going through the motions? Stuck in the same old, same old routine? Well Queen, you're not alone! The spring season is here to refresh and illuminate your next level. Can you feel it? If you, like myself, are ready to clear out the old and make space for the new, then tune into this episode.EPISODE RESOURCESApply for my elite 6-month mastermind La Dolce Vita here (applications due by May 20, 2022)Join my social network, The Q Club, hereSay hi on Instagram @ginadevee Purchase my book The Audacity to be Queen hereADDITIONAL RESOURCES⭐ I'd love to hear your big takeaways! Screenshot this episode and tag me on Instagram at @ginadevee.⭐Be sure to follow the Divine Living Podcast, leave a review, and tune in every week for new episodes.⭐ Purchase my book, The Audacity to be Queen, and receive the FREE companion e-course at https://www.divineliving.com/audacity⭐ Desire Queenhood + community at your fingertips? Download the Q Club app for access to my exclusive social network for women globally: https://www.divineliving.com/tryqclub 

Jessica Brodie and Lori Hatcher discuss Hatcher's book Refresh Your Prayers: Uncommon Devotions to Restore Power and Praise.

Michael Kubacki, Owner and CEO of Armas Environmental Services, joins me to discuss: -What made you decide to get into this business? -What steps do you take with our team to meet with the sellers to make sure they understand the process? -What are the most common upgrades made to a home prior to listing? -Was there one specific upgrade that stood out in your mind as really beneficial to the seller? -How much less than normal contractor pricing do you think Gaddis Group clients get because they are working with you and us?

II. The 5 r's of leadership 1. We must begin by determining responsibilities       A. Essentials or       B. Additional 2. Next we must determine to restrain our involvement. 3. Refresh and retreat 4. Relinquish the additional(s) that drain us 5. Do not be afraid to recruit more help

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The practice of Christian Meditation helps us live with the peace of Christ. Relax to the sounds of beautiful music. How is God renewing your sight? Meditate on Acts 22:12-13. Find peace and rest during this guided meditation for mind and body with deep breathing, prayer, and scripture. Use these meditations as a bible study in the morning to center yourself on the truth in God's word. For more Bible meditations, download the Abide app: https://abide.co/awesome

Your front porch is the first impression someone gets when they visit your home and we learned waaaaaay back in middle school that first impressions matter...a lot! Often times your front porch acts as a preview for what your guests will find inside and now that winter's over, it's time to pay a little more attention to the first impression.  When you design outside with the same attention to detail and intention as you do inside, you can create the atmosphere that you want. Playful, cozy, inviting, whimsical. Whatever you want your home's design to say, you can allude to it by giving your guests a peek-a-boo as to what's to come once they open the front door.  5 ways to refresh your front porch this weekend: 1. Start with a blank slate: clearing everything off the front porch so you can start with a blank slate allows you to do two things - deep clean and think creatively. 2. Choose a color formula: YES, even outside - choose a color formula you want to work with in your outdoor area. Sometimes it can be a replica of what's happening inside. Other times you may want to treat it as its own mini-design habitat. Choosing a color formula helps you make intentional choices when you begin gathering your items. 3. Work from bottom to top: think in layers starting at the foundation - your porch's floor. Layer, add height, texture and depth. And be sure to check for repetition...are design elements (colors, woods, metals, etc.) repeating themselves throughout the front porch design in an effort to create a cohesive look? 4. Design with your senses: Look around at your from porch's design...do you see elements that add to the overall experience? Do you have a variety of textures you can touch, smells you can smell, elements you can hear, like wind chimes. Leaving out the sense of taste but replacing it with feeling - ask yourself how your front porch feels.  5. Add whimsical touches: In this small area, don't be afraid to play! Experiment with design and have fun. Think vertically as well as in layers. Can you hang things on the siding or from the eaves? Think about ambience - do you have lighting other than the overhead porch light? Think 'out of the box' ideas - like teacups as planters, birdcages as vestibules for holding plants. Take risks and have fun!   // Links mentioned in show: // Facebook community: https://bit.ly/design101group Website: www.figandfarmathome.com Work with me: www.figandfarmathome.com/book-a-call   Happy styling! xo, dani        

Rylie Matthews is a developmental bobsled brakeman for Team USA and has successfully competed in the North America Cup as part of that journey. Before jumping into bobsled, Rylie was a NJCAA Division 1 All-American in javelin, and NCAA Division 1 track and field athlete.  After her collegiate career finished she set her sights on bobsleigh and the Olympics. She is a Strength and Conditioning Coach, has a Master's in Professional Communication and is a Certified Performance Enhancement Specialist. In this episode Rylie and podcast host Jamie Allison talk about her development journey with USA Bobsled, her scary first experience in a sled, her transition out of collegiate sports to find her next passion and coaching and helping other athletes.  Be sure to tell Rylie and Jamie what you think about this episode by leaving a review and rating.  It helps us get the message out there!                Refresh and plan!   Find out more   https://linktr.ee/bigideabigmoves           Follow us on Instagram @bigidea_bigmoves        Facebook www.facebook.com/bigideabigmoves             For amazing Lifestyle Clothing epitomesportswear.com Our listeners get 20% off with the code BIBM     For Human Resources and Talent help contact www.epitomeHR.com Take their free assessment          Talk to us about partnerships    https://beacon.by/epitome-hr-inc/bibm-sponsoship-packages      Follow Rylie on IG at @rhyno_ and on Twitter @RHYNO_  

This week's episode is dedicated to knowing that everything happens timely with divine precision.   Lauren Wilson is adept at marketing. She is also well-versed in the arts and luxury goods.  Her resume reads like an illustrious fashion and luxury wish list.  She is currently the founder of Dora Maar, a luxury pre-owned resale site.  Prior to becoming her own boss, she was the business development manager at Moda Operandi; a marketing coordinator at Christie's auction house; the Entertainment Industry Relations Assistant at Gucci, a PR associate at Ralph Lauren; an editorial intern at Vogue; a fashion and shopping intern at Elle; and a press office intern at Jimmy Choo. But wait, there's more.       Her formal education took place at the University of Southern CA, NYU, and the University Paris Sorbonne.  She's major.  Brains, beauty, and style.   Catch the latest episode of the Forever F.A.B. podcast on Apple podcasts, Spotify, YouTube, iheartradio, Podbean, and wherever you listen to your favorite podcasts.  For past episodes featuring guest star interviews, beauty product reviews and innovations in plastic surgery, visit ForeverFABpodcast.com.     Dr. Shirley Madhere is a NYC-based plastic surgeon and Founder of Holistic Plastic Surgery.  This philosophy is based on a whole-body, mind, and spirit approach to beauty and incorporates wellness, integrative nutrition, functional aesthetics, and complementary medicine.   Dr. Madhere's approach to optimal outcomes in plastic surgery is through a lens of wellness, and is grounded in science and backed by ivy league medical study, research, and extensive surgical training.  View her menu of services at ElementsandGraces.com.  Consultations are available in-office, virtually, and online via Click-lift.com.   Coming soon: Dr. Madhere offers beauty on call services through Jet Set Beauty Rx, a mobile medical aesthetics unit delivering beauty in the privacy of your own home.  Reserve at JetSetBeautyRx.com.   As a creative outlet and means to broaden the perspective on the “spectrum of beauty,”  Dr. Madhere created Forever F.A.B., a podcast dedicated to Fashion, the Art of living well (i.e., wellness), and all things Beauty.  Visit ForeverFABpodcast.com for past and new episodes.     If you enjoy listening to the Forever F.A.B. podcast, get more audio and visuals with a membership through Patreon.  Choose the Gold, Platinum, or Diamond tier for premium added content, special co-hosts, lifestyle videos, branded merchandise, and private access to Dr. Shirley's Clubhouse by visiting patreon.com/ForeverFAB.   Catch the latest episode of the Forever F.A.B. podcast on Apple podcasts, Spotify, YouTube, iheartradio, Podbean, Amazon podcasts, and wherever you listen to your favorite podcasts.  For past episodes featuring guest star interviews, beauty product reviews and innovations in plastic surgery, visit ForeverFABpodcast.com.   The F.A.B. Five according to Lauren Wilson:  Recommendations/The F.A.B. Five according to Lauren Wilson: Take weekends off. Recommendations/The F.A.B. Five according to Lauren Wilson: Don't take things or yourself so seriously. Recommendations/The F.A.B. Five according to Lauren Wilson: Build your support network. Recommendations/The F.A.B. Five according to Lauren Wilson: “If it's not going to matter in five years, don't spend more than five minutes worrying about it.” (Anon) Recommendations/The F.A.B. Five according to Lauren Wilson: Always have a “lippy;” never leave home without a good lip! If you want to be a Muse, check out the archival luxury fashion at Dora-Maar.com. Also check it out on social: @shopdoramaar. ***** As always, if you liked this episode of the Forever FAB podcast, please share it and subscribe to the feed. Listen to past episodes or check out who's coming up next on foreverfabpodcast.com.   If you enjoy listening to the Forever F.A.B. podcast, get more audio and visuals with a membership through Patreon.  Choose the Gold, Platinum, or Diamond tier for premium added content, special co-hosts, lifestyle videos, branded merchandise, and private access to my Clubhouse by visiting patreon.com/ForeverFAB.   If you are the Founder of or represent a beauty brand and want to be featured on an episode of the Forever FAB podcast segment of Fifteen Minutes of FAB, send me some stuff.  Visit ForeverFABpodcast.com and fill out the Contact form.   For general holistic beauty tips or to set up an appointment with me to discuss your personalized options for leveling up your beauty, go to ElementsandGraces.com and sign up for my newsletter.   And for an online e-consultation on time, anytime and on your time, visit Click-Lift.com for your wellness, plastic surgery, and beauty questions on the go. And… if you don't want to go anywhere or leave your home, look out for Jet Set Beauty Rx offering mobile aesthetic medical services, such as injectable fillers and multi-vitamin facial treatments.  Jet Set Beauty Rx is coming to your neighborhood soon.   Credits: Video backdrop: custom by Anyvoo Fashion: tank top by Ports 1961; jumper by Tracy Reese Beauty: skincare by Wonderskin Purevoc Makeup: n/a   Produced by www.oneofoneproductions.com Recorded, mixed, edited and original music by www.23dbproductions.com   Podcast Medical Disclaimer The purpose of this podcast is to educate and inform. It is no substitute for professional care by your doctor or your own qualified healthcare professional. Never disregard professional medical advice or delay in seeking it because of something you have read on this podcast or in any linked materials. Guests who speak on this podcast express their own opinions, experience and conclusions, and Dr. Shirley Madhere neither endorses nor opposes any particular opinion discussed in this podcast. The views expressed on this podcast have no relation to those of any academic, hospital, practice, institution or other entity with which Dr. Shirley Madhere may be affiliated.

You can do it all. You're not doing enough. Motherhood isn't enough, you need something else. You're doing too much, you need to be more present. We are constantly bombarded with tons of messages about mom life and it's so confusing. Let's tackle some mom life lies and shine a light on God's truth. What does God say about our role as women, as wives, and as moms? What does God's Word say about these motherhood myths? Press play and let's combat lies together and instead embrace God's truth for motherhood! This is Day 3 of this NEW MOTHERHOOD SERIES. Xoxo Stephanie // EMAIL STEPH —> 500secondstojoy@gmail.com + GET ON THE MONTHLY HAPPY MAIL LIST —> bit.ly/monthlyhappymail // Now here are those Bible verses I refer to in today's episode: Galatians 5:16-24, Ephesians 3:20-21, Romans 5:3-5, James 1:2-4, Luke 9:23-25, Matthew 19:26. Then 1 Peter 5:7-11 and 1 Corinthians 13:7 are the two scriptures we are diving more deeply into in this episode.

This week, please join author Guest Host Mercedes Carnethon, Author Brian Bergmark, and Associate Editor Parag Joshi as they discuss the article “Effect of Vupanorsen on Non–High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70.” Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-host. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center in Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Well Carolyn, this week's feature, non-high density lipoprotein cholesterol levels in statin treated patients with elevated cholesterol. We're going to hear from the TRANSLATE-TIMI 70 study. But before we get to that, how about we grab a cup of coffee and discuss some of the other articles in the issue? Would you like to go first? Dr. Carolyn Lam: I would. And by the way, that feature is going to be all exciting. It was discussed at the American College of Cardiology. But okay, how about from cholesterol to vitamins? Let's start with the Greg quiz. Greg, which vitamins have been associated with arterial calcification? Is it A, B, C, D, E? Dr. Greg Hundley: I'm going to pick E and K. Dr. Carolyn Lam: You're smart. Indeed. Vitamin K2, also known as menaquinone-7 is the most effective co-factor for the carboxylation of proteins involved in the inhibition of arterial calcification. Furthermore, combined low vitamin K and low vitamin D have been associated with increased all-cause mortality risk. And so, today's paper is from Dr. Diederichsen from Odense University Hospital in Denmark and colleagues really present the first double-blind, randomized controlled trial to test whether vitamin K2, a drug-targeting processes of calcification in addition to vitamin D, could slow the progression of aortic valve calcification and stenosis. So, in a randomized double-blind multicenter trial, men from the community with an aortic valve calcium score above 300 arbitrary units on cardiac non-contrast CT were randomized to daily treatment with 720 micrograms of vitamin K2 plus 25 micrograms of vitamin D or matching placebo for 24 months. And the primary outcome was the change in aortic valve calcium score. Dr. Greg Hundley: Carolyn, so menaquinone-7 and aortic valve score. So, what were the results? Dr. Carolyn Lam: Menaquinone-7 had no major effect on the progression of aortic valve calcification as assessed by CT or echo. High-dose menaquinone-7 was, however, safe and well tolerated. Now, some limitations is that this external validity is limited to men aged 65 to 74 with aortic valve calcification scores of greater or equals to 300 arbitrary units. Thus, caution is needed if we extrapolate these findings and other pathways need to be explored in order to identify an effective therapy for this unmet clinical need. Dr. Greg Hundley: Wow, very nice Carolyn. Well, my first article comes to us from Dr. Michael Laflamme from the University Health Network. And Carolyn, human pluripotent stem cell-derived cardiomyocytes or hPSC-CMs exhibit promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. So Carolyn, this research team hypothesized that large scale manufacturing of mature hPSC-CMs could be achieved via culture on polydimethylsiloxane, and we're going to call that PDMS, lined roller bottles and that the transplantation of these cells would mediate better structural and functional outcomes then with conventional immature hPSC-CMs populations. Dr. Carolyn Lam: Oh, that's neat, Greg. So, what did they find? Dr. Greg Hundley: Right, Carolyn. So, these authors demonstrated the economic generation of greater than one times 10 to the eighth mature hPSC-CMs per PDMS line roller bottle. And compared to their counterparts, PDMS matured hPSC-CMs exhibited increased cardiac gene expression and more mature structural and functional properties in vitro. More importantly, intracardiac graphs formed with PDMS matured myocytes showed greatly enhanced structured alignment, better host graft electromechanical integration, less pro arrhythmic behavior, and greater beneficial effects on contractile function. So in summary, Carolyn, this team describes practical methods for the scale generation of mature human pluripotent stem cell-derived cardiomyocytes and provide the first evidence that the transplantation of more mature cardiomyocytes yields better outcomes in vivo. And there's a wonderful editorial by Professor Murray entitled Flexing Their Muscles: Maturation of Stems Cell-Derived Cardiomyocytes on Elastomeric Substrates to Enhance Cardiac Repair. Dr. Carolyn Lam: Wow! That's really significant. Thank you, Greg. Well, the next paper is the largest genome-wide association meta-analysis of plasma ACE2 levels in over 28,000 individuals. And this is from Dr. Xia Chen from Fudan University and Dr. James Wilson from University of Edinburgh in UK, and their colleagues. And guess what, it focuses on severe acute respiratory syndrome coronavirus 2, the etiologic agent of COVID 19. And we know that that enters human cells using the ACE2 protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart, respiratory and gastrointestinal tracts, playing important regulatory roles in the cardiovascular and other biologic systems. Dr. Greg Hundley: Wow, Carolyn. ACE2, and also a very important topic here with SARS-COVID-2. So, what did they find? Dr. Carolyn Lam: First, the overall heritability of ACE2 level is 16% of which 30% can be explained by 10 protein quantitative trait loci identified in this study. ACE2 level is genetically correlated with both COVID-19 and cardiovascular. Elevated ACE2 levels show a causal relationship with COVID-19 severity, hospitalization and infection as shown by Mendelian randomization analyses. ACE2 regulatory variants are enriched on DNA methylation sites in immune cells. Dr. Greg Hundley: Wow, Carolyn. So, elevated ACE2 and a causal relationship with COVID-19 severity. So tell us, what are the clinical applications of this really nice study? Dr. Carolyn Lam: The causal evidence of ACE2 suggests that pharmacological inhibition of circulating ACE2 may be a promising approach for treating COVID-19 or its comorbidities. Transcription factors that play essential roles in ACE2 generation could provide alternative paths to pharmacological modulation of ACE2 plasma levels. The genetic correlations between ACE2 and both COVID-19 and cardiovascular disease imply that the cardiovascular complications seen in COVID-19 patients may be intrinsic to the disease and mechanically or/and mechanistically-driven by ACE2. Isn't that neat? Dr. Greg Hundley: You bet, Carolyn. Boy, what an exciting issue. And we've got other articles in this issue. Dr. Carolyn Lam: Yeah. Now, let me start this time. There's an exchange of letters between Drs. Duan and Chang regarding the article “Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy in Vivo.” There's a Perspective piece by Dr. Morris, “The Updated Heart Failure Guidelines: Time for a Refresh.” Love that piece! There's an AHA Update piece (AHA President's Page) by Dr. Elkin on The Road to Equity in Brain Health, and ECG challenge by Dr. Kolominsky, Electrical Extremists in a Critically ill Patient, and an On My Mind Paper by Dr. Paulus entitled “Border Disputes Between Heart Failure Phenotypes.” Dr. Greg Hundley: Wow, Carolyn. And I've got two Research Letters. The first from Professor Groeneveld entitled “Prevalence of Short-Coupled Ventricular Fibrillation in a Large Cohort of Dutch Idiopathic Ventricular Fibrillation Patients.” And then a second Research Letter from Professor Yamashita entitled “Single Cell RNA Sequence Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome.” Well Carolyn, now, we get to go onto our feature, vupanorsen on non-high-density lipoprotein cholesterol levels and catching up with TIMI 70. Dr. Carolyn Lam: Let's go. Dr. Mercedes Carnethon: So, good morning listeners. I'm really pleased to invite you to this episode of our Circulation on the Run podcast. For those of you who don't hear me often, I'm stepping in as a guest host today. My name is Mercedes Carnahan from the Northwestern University Feinberg School of Medicine. And I'm really excited to be joined today by Dr. Brian Bergmark, and associate editor, Dr. Parag Joshi. And we will have today Dr. Bergmark discussing his new article published with us on the effects of vupanorsen on non-HDL cholesterol levels in the TRANSLATE-TIMI 70 trial. We're really thrilled to have you with us here today, Brian, to talk about the really important findings coming from this trial. So to start us off, just tell us, what did you find? Dr. Brian Bergmark: Great. Thank you so much. It's really a pleasure to be here and I'm grateful for the opportunity. So, in the big picture, despite numerous agents to reduce lipid-mediated cardiovascular risk, obviously, residual risk remains and there are novel targets to address that risk. One of them is angiopoietin-like 3, which is a protein made in the liver. Angiopoietin-like 3 or ANGPTL3 inhibits lipoprotein lipases among other lipases, and thereby interferes with metabolism of triglyceride-rich lipoproteins. And so, the idea here was that if ANGPTL3 could be inhibited that LPL or lipoprotein lipase function could be augmented and metabolism of these lipoproteins could be augmented. And so, what we did is we took patients with an elevated non-HDL cholesterol, at least 100 milligrams per deciliter, and elevated triglycerides, 150 to 500 milligrams per deciliter, and randomized them to placebo or one of seven doses of vupanorsen, which is an antisense oligonucleotide, which inhibits the synthesis of ANGPTL3 in the liver. We then follow them to see what the impact was on their non-HDL cholesterol, as well as other lipid parameters through 24 weeks. Dr. Mercedes Carnethon: Thank you so much. It's a wonderful design, and I'm really excited to hear a little bit more about what you found. Dr. Brian Bergmark: Great. So, the primary endpoint was the change in non-HDL cholesterol from baseline to 24 weeks. And we did find that all vupanorsen regimens reduced non-HDL cholesterol in a statistically significant manner. The magnitude of that effect was up to 27.7% in one of the dose arms or about 28%. We also saw a statistically significant reductions in the target ANGPTL3 up to about a 95% reduction in the highest dose arm, as well as statistically significant reductions in triglycerides at all of the dose regimens. The effect on LDL cholesterol and on apolipoprotein B or apo B was variable across regimens and only statistically significant in a few of the dose arms. We also found several safety signals. One, there appeared to be higher rates of injection site reactions in the skin at higher total monthly doses. We also found higher rates of elevation in liver enzymes, AST and ALT at higher total monthly doses. And we also found significant increases in hepatic fat fraction or the fat content of the liver at higher total monthly doses. Dr. Brian Bergmark: In the end, we found that while statistically significant, the magnitude of the reduction in non-HDL cholesterol was modest as was the reduction in apo B. And so, the goal here was to find a dose that might have a reduction of a magnitude that would be clinically meaningful for cardiovascular risk reduction. We were underwhelmed by the magnitude of that reduction, and then it was paired with these safety signals, which if there's interest, we could get into more detail in our thinking about why those occurred, what the implications are, but suffice it to say that there were medically meaningful safety concerns paired with a modest reduction in non-HDL cholesterol. Dr. Mercedes Carnethon: Thank you for that excellent summary. Before I turn it over to the associate editor, I read this with great interest, and in particular, looking at one of the first figures in the paper, which is demonstrating the adjusted change at 24 weeks across different doses and based on how frequently the doses were given the four week as compared with the two week. And one thing that really stood out to me was the clear dose response with the four week regimens with the higher doses appearing to demonstrate the greatest reductions but a less clear signal with the two week regimens. Do you have any hypotheses about why these patterns appeared so different? Dr. Brian Bergmark: Yeah. It's a great question. So, the responsiveness of this is something of interest here I think. So, if you look at the effect of the drug on its target, ANGPTL3, there is a very clear dose response, so there's no doubt that higher doses were impacting the target ANGPTL3 to a greater extent. So, one of the most direct effects would be on triglycerides, one of the most direct lipid effects, and that appears pretty close to a dose response relationship within each of these frequencies of administration. But once you start getting to non-HDL cholesterol, it starts to break down a bit. And is it simply because of random chance or is there actually something distinct going on with how the lipids are being metabolized? Dr. Brian Bergmark: That is something we are diving into. So, the hope would be that we actually reduce apo B, the number of these actually circulating lipoproteins as has been demonstrated with the monoclonal antibody. It's possible that with this other different mechanism in the antibody, this antisense oligonucleotide, perhaps, we're simply shifting the content of these lipoprotein molecules and decreasing the triglyceride content but not actually meaningfully modifying the amount of apo B, LDL cholesterol. And that might be part of what we're seeing with the more muted relationship between dose and the effect on non-HDL cholesterol. I don't know for certain we are diving into this a bit more with other lipid fractions, et cetera. Dr. Mercedes Carnethon: Oh, well, thank you so much for that explanation. I know that a number of people, this was extremely well received when shared at the recent American College of Cardiology meetings, and so I was really thrilled to find that this was appearing in the journal circulation. So Parag, I'm really interested in hearing your perspectives on why we knew that this was certainly a priority paper for us. Dr. Parag Joshi: Yeah. Let me first start, Brian, congratulations. Fantastic work. And we were excited to receive the paper. I think really hard to pull off trials right now or in the last couple years, so kudos to you. And I echo the sentiments from Mercedes. This is great work. Really important space, the residual risk space I think is very important of course and is critical to moving forward with improving cardiovascular health. So, one of the big picture questions and as we get to this triglyceride-rich lipoprotein lowering space, certainly, there's strong associations with residual risk, but can we impact that risk? And here, we're starting to explore that. And I think when you think of the lipoprotein space, many of us are interested in what is the effect on these lipoproteins as opposed to the cholesterol content or the triglyceride content. And non-HDL cholesterol or apo B, clearly, the better, stronger markers for that risk, so we were really excited to see this paper.   Dr. Parag Joshi: And as Brian mentioned, unfortunately, not the strongest impact here on those measures. And I want to dive into that a little more because I think that carries significant implications for the space, and I'd love to hear your thoughts on that. But overall, really fantastic work. I think my first question really is around the apo B aspect of this and the less than anticipated lowering of those levels. You hinted at this in terms of, is this shuffling cholesterol and triglycerides across particles, or do you think this could be the mechanism by which this happens through ANGPTL3? You do inhibit the levels quite a bit. Did we just miss that... Is this not the right target? What do you think? Dr. Brian Bergmark: Yeah, it's a great question. I do think the target itself holds great promise. Obviously, a monoclonal antibody against this same target results in major reductions in apo B, LDL cholesterol, and the latter through a mechanism that is not really known but is not dependent on the LDL receptor, and therefore has real clinical utility that's approved for people with familial homozygous hypercholesterolemia. Beyond that, of course, in genetic studies, there's a clear association with loss of function in the ANGPTL3 gene and lower levels of all of these lipids, lower rates of coronary artery disease, et cetera. Dr. Brian Bergmark: So, I think it's not that this pathway is not promising and actually already being taken advantage of, I think it's that this particular agent acting through this mechanism was not able to achieve a necessary efficacy with reasonable safety. Some genetic data suggests that there is not actually a dose response between a reduction or loss of function in ANGPTL3 and reduction in apo B or lower levels of apo B and non-HDL cholesterol, but it really requires your complete elimination of ANGPTL3 function, which is probably, likely achieved with the monoclonal antibody. And so, even though we had quite large reductions with the antisense oligonucleotide, perhaps, we just didn't cross that threshold that's needed to modify the lipid panel in the way that would've been clinically meaningful. Dr. Parag Joshi: Yeah. I think that's fantastic as you allude to with evolocumab and the impact that has on apo B levels. I didn't think of it as a threshold effect, but that makes a lot of sense as maybe that just getting to that tipping point is where the issue is here. In terms of the liver signal, what were your thoughts on that? And is that something that we should expect to see in ASOs or do you think it's specific to this compound? Dr. Brian Bergmark: Yeah, I don't know. That was unexpected. Right, there are two liver signals and it's unclear how related they are. One is the inflammation of the liver as indicated by the elevation in enzymes, and then the other is the fat accumulation. So with respect to the fact, if anything, genetic data suggests perhaps loss of function in ANGPTL3 might result in lower rates of hepatic steatosis. In animal models, the antisense oligonucleotide reduces liver fat, and so there's, there was promise going into this that this could actually be beneficial for non-alcoholic fatty liver disease. And additionally, there's not data to suggest that the monoclonal antibody increases liver fat. So, there's not a lot to support this as being an on-target effect that by inhibiting ANGPTL3, by that pathway, the liver fat was increased. So, I think a reasonable person might wonder whether this was an off-target effect of the drug. Dr. Brian Bergmark: By what mechanism that occurred, I don't know, what the implications would be for other related agents, I don't know. And then similarly, the liver enzyme elevations, is that related to this? I'm not exactly sure, but also unexpected and I think off-target. But that sort of intrinsic to this mechanism of hepatic targeting, is this something we need to be worried about for other agents in this class or not? I don't know. Obviously, we can't answer that from this single study. We are going to dive into it a bit more to try to overlay patients with hepatic fat accumulation, liver enzymes, et cetera. Of course, both of those happen more at higher doses. How much we can really parse this? I'm not sure yet. Dr. Parag Joshi: Yeah. That's really fascinating. I think the appeal of this paper to the circulation audience is that you have a really exciting novel target and pathway to explore here but somewhat divergent results from what's existing in this space. And I think that raises a lot of questions, really interesting questions going forward for this space. For the ANGPTL3 pathway, what do you see there coming down the line or what are your thoughts on that going forward for this target and ways to approach risk related to it? Dr. Brian Bergmark: Yeah. Great. Thank you. Yeah. No, so I agree. I think moving into this other end of the spectrum of triglyceride-rich lipoproteins, et cetera, I think this is where we're headed and this is why we do the trial. We weren't expecting these things that's why you do this experiment, and this is what we found. So now, where do we go from here? So there are, of course, other ways beyond the monoclonal antibody of targeting ANGPTL3 specifically. There's siRNA, there is gene therapy being investigated. So, I think all of them hold an great promise. And of course, we will need to see as those therapies move along what the actual trials show. And then there are, of course, other pathways that are of interest, APOC3, for instance. So, I think there's a lot more in this space that's coming down the line. Dr. Parag Joshi: Yeah, absolutely. I think it's a really exciting space, and we're really happy to get this paper as one piece of that whole puzzle. So, thank you. Dr. Mercedes Carnethon: Yes. And I echo that as well. And as a methodologist myself, I'm always really pleased to see such well-designed studies. I think this was sophisticated in many aspects in testing different dosing and different timing of the dosing. And also, I'm really impressed by your inclusion criteria, particularly when I noted that 44% of the participants were female, and that you reported those stratum-specific effects. I just had a final question as we wrap up. You acknowledge a nominally significant interaction by sex and I see, for example, that it appears that the magnitude is larger possibly in the relatively smaller subset of females as compared with males. Is this something to pay attention to or do you think this is just some type of an artifact related to greater variability because the group is smaller? Dr. Brian Bergmark: Yeah, it's a good question. So, this is the burning question. We had no a priority reason to suspect that biologically and we are not adjusting for multiple testing in the key value of 0.04. So just to put my money down, I would say, I would guess it's random chance. We found it. It's worthy of looking into a bit more. There were, of course, the important implications for other drugs, et cetera. So, I think it's worth diving into as we will, but are we likely to uncover some biological difference? I doubt it. I wouldn't guess. There are other subgroups where I think at least upfront, you might expect there could be a difference. So, there are thoughts about insulin's effect on LPL. Could diabetes status have an interaction with the drug? I think though not statistically significant, it's also something worth looking into that group and the subfractions of the lipid panel and all of that stuff. So, I think it's all worth looking into but cautiously with the constraints. Dr. Mercedes Carnethon: Well, thank you so much for that explanation. And I've really enjoyed this discussion with you today, Brian, and you, Parag. I've certainly learned a lot and I'm really excited to see this excellent work coming out in the journal circulation. So, thank you very much for your time this morning and thank you to our listeners. Wrapping up this episode of Circulation on the Run. Dr. Greg Hundley: This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

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Kris Rugloski is an elite obstacle course racer completing over 40 of them and racking up more than 30 podium finishes. After not participating in sports throughout high school or college like most of her peers, she is now enjoying being a true hybrid athlete. She has completed nine 100 mile ultra runs and is quickly becoming a HYROX World Competition favorite.  She was a competitor on the Rock's The Titan Games and went up against some of the top athletes in her sports on the recently released Spartan Games 2. In this episode she talks with host Jamie Allison about how she has developed her mental resilience through taking on tough challenges, how she is enjoying her best life right now by integrating her work, sports and social life, and she talks about her experience on Spartan Games 2. Be sure to tell Kris and Jamie what you think about this episode by leaving a review and rating.  It helps us get the message out there!               Refresh and plan!   Find out more   https://linktr.ee/bigideabigmoves          Follow us on Instagram @bigidea_bigmoves        Facebook www.facebook.com/bigideabigmoves            For amazing Lifestyle Clothing epitomesportswear.com Our listeners get 20% off with the code BIBM    For Human Resources and Talent help contact www.epitomeHR.com Take their free assessment         Talk to us about partnerships    https://beacon.by/epitome-hr-inc/bibm-sponsoship-packages     Follow Kris on IG at @krisrugloski 

Hey Friend! In today's episode, I am doing a podcast refresh session with one of my prior students and clients, Emily Nichols From the Self Transformed Podcast. I help Emily dig into her podcast SEO, keywords, description, and review titles with her to make sure that her 100K download show keeps flourishing and moving towards that 1 Million mark. If you have podcasting on your heart, or already have one - this episode is a must-listen! Revising and revamping your show annually helps you continue to niche into who your listener is, and find out what they want. Serving them well is our #1 objective. I pray this blesses you! Xo, Stef   All the things -> www.stefaniegass.com   Free Female Christian Entrepreneur Community-> www.stefgasscommunity.com Ready to get clear on your calling so you can start an online business? Join my Free, 4-Step Clarity Framework Workshop! Instant access at-> www.freeclarityworkshop.com Need a step-by-step blueprint on how to start your online business? Download a Free, 14-Step Biz Blueprint Checklist!-> www.completebusinessblueprint.com Wondering if you should start a podcast? Take this quiz and find out! -> www.startapodcastquiz.com   Wanna work together, friend!? Step 1: Get Clear on Your God-led Calling so You Can Start an Online Business-> www.clarifyyourcallingcourse.com Step 2: Grow an Organic, Evergreen Audience using Podcasting-> www.podcastprouniversity.com  Step 3: Monetize & Scale your Podcast Using Courses and Coaching-> www.podcasttoprofitmastermind.com    Contact us at-> support@stefaniegass.com

Craig and Sean welcome Troy Terry of the Anaheim Ducks to discuss the up and coming Ducks, playing and learning from the legendary Ryan Getzlaf, skilling it up, Tyson Nash, Auston Matthews and keeping up with multi talented line-mate Trevor Zegras. Gentille and Custance take a look at the NHL's schedule and the playoff format and share their frustration with how the NHL has handled both and that change to both is long overdue. In the only good segment on the show, the Tuesday boys answer your comments including who won the Pacioretty/Suzuki trade, the Jekyll and Hyde Dallas Stars, who the current most underrated American born player is and what dog breed exudes the essence of American hero Phil Kessel? Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome back, sleepyheads. Tonight is the first in a magical two-part series set in a curious world hidden away in the woods. The original idea for these tales came from one of our wonderful, creative listeners. Check back here on Wednesday for part two. We hope you enjoy it!

With family: Numbers 2; Psalm 36 Numbers 2 (Listen) Arrangement of the Camp 2 The LORD spoke to Moses and Aaron, saying, 2 “The people of Israel shall camp each by his own standard, with the banners of their fathers' houses. They shall camp facing the tent of meeting on every side. 3 Those to camp on the east side toward the sunrise shall be of the standard of the camp of Judah by their companies, the chief of the people of Judah being Nahshon the son of Amminadab, 4 his company as listed being 74,600. 5 Those to camp next to him shall be the tribe of Issachar, the chief of the people of Issachar being Nethanel the son of Zuar, 6 his company as listed being 54,400. 7 Then the tribe of Zebulun, the chief of the people of Zebulun being Eliab the son of Helon, 8 his company as listed being 57,400. 9 All those listed of the camp of Judah, by their companies, were 186,400. They shall set out first on the march. 10 “On the south side shall be the standard of the camp of Reuben by their companies, the chief of the people of Reuben being Elizur the son of Shedeur, 11 his company as listed being 46,500. 12 And those to camp next to him shall be the tribe of Simeon, the chief of the people of Simeon being Shelumiel the son of Zurishaddai, 13 his company as listed being 59,300. 14 Then the tribe of Gad, the chief of the people of Gad being Eliasaph the son of Reuel, 15 his company as listed being 45,650. 16 All those listed of the camp of Reuben, by their companies, were 151,450. They shall set out second. 17 “Then the tent of meeting shall set out, with the camp of the Levites in the midst of the camps; as they camp, so shall they set out, each in position, standard by standard. 18 “On the west side shall be the standard of the camp of Ephraim by their companies, the chief of the people of Ephraim being Elishama the son of Ammihud, 19 his company as listed being 40,500. 20 And next to him shall be the tribe of Manasseh, the chief of the people of Manasseh being Gamaliel the son of Pedahzur, 21 his company as listed being 32,200. 22 Then the tribe of Benjamin, the chief of the people of Benjamin being Abidan the son of Gideoni, 23 his company as listed being 35,400. 24 All those listed of the camp of Ephraim, by their companies, were 108,100. They shall set out third on the march. 25 “On the north side shall be the standard of the camp of Dan by their companies, the chief of the people of Dan being Ahiezer the son of Ammishaddai, 26 his company as listed being 62,700. 27 And those to camp next to him shall be the tribe of Asher, the chief of the people of Asher being Pagiel the son of Ochran, 28 his company as listed being 41,500. 29 Then the tribe of Naphtali, the chief of the people of Naphtali being Ahira the son of Enan, 30 his company as listed being 53,400. 31 All those listed of the camp of Dan were 157,600. They shall set out last, standard by standard.” 32 These are the people of Israel as listed by their fathers' houses. All those listed in the camps by their companies were 603,550. 33 But the Levites were not listed among the people of Israel, as the LORD commanded Moses. 34 Thus did the people of Israel. According to all that the LORD commanded Moses, so they camped by their standards, and so they set out, each one in his clan, according to his fathers' house. (ESV) Psalm 36 (Listen) How Precious Is Your Steadfast Love To the choirmaster. Of David, the servant of the LORD. 36   Transgression speaks to the wicked    deep in his heart;1  there is no fear of God    before his eyes.2   For he flatters himself in his own eyes    that his iniquity cannot be found out and hated.3   The words of his mouth are trouble and deceit;    he has ceased to act wisely and do good.4   He plots trouble while on his bed;    he sets himself in a way that is not good;    he does not reject evil. 5   Your steadfast love, O LORD, extends to the heavens,    your faithfulness to the clouds.6   Your righteousness is like the mountains of God;    your judgments are like the great deep;    man and beast you save, O LORD. 7   How precious is your steadfast love, O God!    The children of mankind take refuge in the shadow of your wings.8   They feast on the abundance of your house,    and you give them drink from the river of your delights.9   For with you is the fountain of life;    in your light do we see light. 10   Oh, continue your steadfast love to those who know you,    and your righteousness to the upright of heart!11   Let not the foot of arrogance come upon me,    nor the hand of the wicked drive me away.12   There the evildoers lie fallen;    they are thrust down, unable to rise. Footnotes [1] 36:1 Some Hebrew manuscripts, Syriac, Jerome (compare Septuagint); most Hebrew manuscripts in my heart (ESV) In private: Ecclesiastes 12; Philemon Ecclesiastes 12 (Listen) Remember Your Creator in Your Youth 12 Remember also your Creator in the days of your youth, before the evil days come and the years draw near of which you will say, “I have no pleasure in them”; 2 before the sun and the light and the moon and the stars are darkened and the clouds return after the rain, 3 in the day when the keepers of the house tremble, and the strong men are bent, and the grinders cease because they are few, and those who look through the windows are dimmed, 4 and the doors on the street are shut—when the sound of the grinding is low, and one rises up at the sound of a bird, and all the daughters of song are brought low—5 they are afraid also of what is high, and terrors are in the way; the almond tree blossoms, the grasshopper drags itself along,1 and desire fails, because man is going to his eternal home, and the mourners go about the streets—6 before the silver cord is snapped, or the golden bowl is broken, or the pitcher is shattered at the fountain, or the wheel broken at the cistern, 7 and the dust returns to the earth as it was, and the spirit returns to God who gave it. 8 Vanity2 of vanities, says the Preacher; all is vanity. Fear God and Keep His Commandments 9 Besides being wise, the Preacher also taught the people knowledge, weighing and studying and arranging many proverbs with great care. 10 The Preacher sought to find words of delight, and uprightly he wrote words of truth. 11 The words of the wise are like goads, and like nails firmly fixed are the collected sayings; they are given by one Shepherd. 12 My son, beware of anything beyond these. Of making many books there is no end, and much study is a weariness of the flesh. 13 The end of the matter; all has been heard. Fear God and keep his commandments, for this is the whole duty of man.3 14 For God will bring every deed into judgment, with4 every secret thing, whether good or evil. Footnotes [1] 12:5 Or is a burden [2] 12:8 The Hebrew term hebel can refer to a “vapor” or “mere breath” (three times in this verse); see note on 1:2 [3] 12:13 Or the duty of all mankind [4] 12:14 Or into the judgment on (ESV) Philemon (Listen) Greeting 1 Paul, a prisoner for Christ Jesus, and Timothy our brother, To Philemon our beloved fellow worker 2 and Apphia our sister and Archippus our fellow soldier, and the church in your house: 3 Grace to you and peace from God our Father and the Lord Jesus Christ. Philemon's Love and Faith 4 I thank my God always when I remember you in my prayers, 5 because I hear of your love and of the faith that you have toward the Lord Jesus and for all the saints, 6 and I pray that the sharing of your faith may become effective for the full knowledge of every good thing that is in us for the sake of Christ.1 7 For I have derived much joy and comfort from your love, my brother, because the hearts of the saints have been refreshed through you. Paul's Plea for Onesimus 8 Accordingly, though I am bold enough in Christ to command you to do what is required, 9 yet for love's sake I prefer to appeal to you—I, Paul, an old man and now a prisoner also for Christ Jesus—10 I appeal to you for my child, Onesimus,2 whose father I became in my imprisonment. 11 (Formerly he was useless to you, but now he is indeed useful to you and to me.) 12 I am sending him back to you, sending my very heart. 13 I would have been glad to keep him with me, in order that he might serve me on your behalf during my imprisonment for the gospel, 14 but I preferred to do nothing without your consent in order that your goodness might not be by compulsion but of your own accord. 15 For this perhaps is why he was parted from you for a while, that you might have him back forever, 16 no longer as a bondservant3 but more than a bondservant, as a beloved brother—especially to me, but how much more to you, both in the flesh and in the Lord. 17 So if you consider me your partner, receive him as you would receive me. 18 If he has wronged you at all, or owes you anything, charge that to my account. 19 I, Paul, write this with my own hand: I will repay it—to say nothing of your owing me even your own self. 20 Yes, brother, I want some benefit from you in the Lord. Refresh my heart in Christ. 21 Confident of your obedience, I write to you, knowing that you will do even more than I say. 22 At the same time, prepare a guest room for me, for I am hoping that through your prayers I will be graciously given to you. Final Greetings 23 Epaphras, my fellow prisoner in Christ Jesus, sends greetings to you, 24 and so do Mark, Aristarchus, Demas, and Luke, my fellow workers. 25 The grace of the Lord Jesus Christ be with your spirit. Footnotes [1] 1:6 Or for Christ's service [2] 1:10 Onesimus means useful (see verse 11) or beneficial (see verse 20) [3] 1:16 For the contextual rendering of the Greek word doulos, see Preface; twice in this verse (ESV)

Self care can be described as the active process of making your body, mind, and even your living space a pleasant place to inhabit.  We hope today's episode leaves you feeling inspired and perhaps with a few ideas to tackle some home projects or face-lifts that will leave you feeling productive, refreshed, and loving your humble abode! Patreon | Love what you're hearing? Help fund ongoing episodes through donations as little as $1/month. Learn more here! Leave a review | When you leave a five star iTunes review, it helps others with similar interests and passions find us when they're looking for new content. Thank you in advance! Resources and Show Notes storage baskets from Wayfair Foundstone™ Gwen 46'' Console Table & Reviews | Wayfair Cat Wall Instagram - GYST Organized  

Welcome to the latest Bat Area-month edition of "The Pan Dulce Life Mixshow!" Yup, you read that right! To honor our co-host Murcielago Mayor aka Fruit Bat's birthday, the Bay Area is now the Bat Area!

Catch us every morning, 5 days a week, for our Daily Drop-In live series at 7:00am Eeastern. Join us for interviews with educators from all around the world, valuable resources, motivation, inspiration, and a whole lot of fun! For more visit www.teachbetter.com --- Send in a voice message: https://anchor.fm/teach-better-talk/message

Taking time to enjoy nature and thank God for all of it renews our souls. Reflect his beauty back to him by making time to explore the world he has created and praise him for it.