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Andy and Jeff talk about all of the moves in the NBA that the title contenders have made this off season and wonder if the reason the Cavaliers haven't made any big moves is because they're expecting LeBron to return to Cleveland.
A. Indictment of Idolatry B. Incoming Judgment C. Indication of Hope
How should prostate biopsy be performed in the MRI era, and what impact does biopsy strategy have on treatment planning?In this episode, Prof. Francesco Sanguedolce is joined by Prof. Francesco Giganti, Prof. Gianluca Giannarini and Prof. Lars Budäus to discuss the latest expert recommendations on prostate biopsy.The conversation explores the importance of high-quality MRI, targeted and perilesional biopsy strategies, the role of emerging imaging technologies and the ongoing debate surrounding systematic biopsy.The faculty also discuss how biopsy findings can influence decisions on focal therapy, nerve-sparing surgery and lymph node dissection, while highlighting current areas of consensus and the questions that still remain in clinical practice.ProBIOPSY: A Multidisciplinary International Consensus on Standards for Prostate Biopsy, European Urology, article in press. Doi.org/10.1016/j.eururo.2026.06.012)This podcast is brought to you in collaboration with the EAU Section of Urological Imaging.For more EAU podcasts, please go to your favourite podcast app and subscribe to our podcast channel for regular updates: Apple Podcasts, Spotify, EAU YouTube channel.
Le pagne baoulé est l'un des symboles du patrimoine culturel ivoirien. Mais derrière ces étoffes colorées se cache un savoir-faire ancestral transmis de génération en génération. À Bomizambo, localité située à une trentaine de kilomètres de Yamoussoukro, les métiers à tisser résonnent encore grâce à des artisans qui refusent de laisser disparaître cet héritage, malgré les difficultés qu'ils rencontrent. De notre envoyé spécial à Bomizambo, Victorien Kouamé actionne les pédales pour faire se croiser les fils, puis il fait glisser la navette d'un côté à l'autre avant de resserrer la trame avec le peigne : bande après bande, le pagne baoulé prend forme. À plus de cinquante ans, Victorien pratique cet art depuis l'école primaire. Un savoir-faire transmis par son père : « Au CM2 après l'école, c'est lui qui m'a appris le tissage, raconte-t-il. Et des parents m'ont aussi aidé à apprendre les motifs. Je sais comment tisser le pagne baoulé. Je connais toutes les qualités de pagnes baoulé ». Chaque pagne est entièrement tissé à la main. Un travail minutieux qui constitue aussi la principale source de revenus de nombreux artisans, même si le tissage ne suffit pas toujours à faire vivre une famille, reconnaît cet artisan : « Notre activité principale, c'est le tissage. Après le tissage, on peut ensuite aller au champ. Je peux prendre cinq jours pour tisser parce que c'est ça qui me procure l'argent. Puis, on se débrouille pour aller au champ, y chercher à manger ». Mais les tisserands de Bomizambo font face à de nombreux défis : le coût élevé des matières premières, et surtout la concurrence, qu'ils jugent déloyale, des tissus industriels. « Les gens produisent ces pagnes en masse, sous forme de tissus avec les photos de nos motifs. Lorsque de loin tu aperçois ces tissus portés, tu peux te dire que c'est un pagne baoulé que la personne a. Or, de près tu vois que c'est un tissu simple. Celaa nous fatigue beaucoup », déplore Richard Kouassi, à la tête d'une coopérative qui compte plus de 300 membres. Autre défi : la transmission de ce savoir-faire ancestral. Sur le site, quelques jeunes tentent malgré tout de s'y intéresser. Parmi eux, Martial, qui après un échec au baccalauréat, s'est tourné vers la confection du pagne baoulé. Une aubaine pour lui : « Moi, je m'en sors. Parce que quand tu t'organises bien, dans ce métier, tu peux t'en sortir. Dans le mois, je peux gagner la somme de 150 000 francs CFA », soit environ 228 euros. Le pagne baoulé bénéficie depuis 2023 d'un label Indication géographique protégée, délivré par l'Organisation africaine de la propriété intellectuelle. Une reconnaissance qui vise à valoriser le savoir-faire des tisserands ivoiriens et à lutter contre la contrefaçon.
durée : 00:02:29 - Labellisation à laquelle travaillent les producteurs et transformateurs insulaires en cours... La chimie de nos immortelles insulaires est particulière bien que plurielle. Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France
In this first part of a special two-episode series of TOGA's Conversations in Lung Cancer Research podcast, A/Prof Deme Karikios, a Medical Oncologist at the Nepean Hospital in NSW, is joined by Prof Ken O'Byrne, a Consultant and Professor in Medical Oncology at the Princess Alexandra Hospital and the Queensland University of Technology, and A/Prof Rachel Roberts-Thomson, a Medical Oncologist at The Queen Elizabeth Hospital and Cancer Care Adelaide. The panel discusses the recent, groundbreaking broad PBS listing of certain immunotherapy agents in Australia, including the removal of 'once in a life time' rule. This major structural shift moves oncology prescribing away from rigid, indication-specific silos and toward clinician discretion guided by a patient's individual biology and the best available clinical evidence. This episode also covers what this means for advanced and metastatic thoracic malignancies, the biological rationale behind single versus doublet immunotherapy, and the practicalities of managing these clinical decisions. Podcast Sponsor Note: This podcast was proudly sponsored by Bristol Myers Squibb. All development and editorial decisions were made independently by the speakers. Resource Links: CM816 https://www.nejm.org/doi/full/10.1056/NEJMoa2202170 CM9LA https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30641-0/abstract CM227-https://www.nejm.org/doi/full/10.1056/NEJMoa1910231 CM227 was a clinical trial that examined ipi/nivo, nivo alone or chemotherapy in pts with NSCLC with PD-L1 expression level of 1% (00:00) Welcome and Acknowledgement (02:00) New PBS Listing Explained (04:18) Defining Advanced and Sensitive (07:18) Dual vs Single Immunotherapy (12:27) Early Stage and Recurrence (14:26) Duration Stopping and Restarting (20:57) Other Thoracic Cancers (23:55) System Impact and Wrap Up Support TOGAThank you for listening to Conversations in Lung Cancer Research. If you enjoyed this episode, please rate and review us on Apple Podcasts or Spotify.---------------Connect with TOGAAttend an Event: https://thoraciconcology.org.au/events/Become a Member: Join the TOGA community at https://thoraciconcology.org.au/membership/Donate: Support our research and treatment initiatives at https://thoraciconcology.org.au/support-us/donate/Follow UsLinkedIn: https://www.linkedin.com/company/thoracic-oncology-group-of-australasia/X (Twitter): https://x.com/TOGAANZInstagram: https://www.instagram.com/togaanz/YouTube: https://www.youtube.com/@Thoracic_Oncology---------------Acknowledgement of CountryThe Thoracic Oncology Group of Australasia Limited acknowledges Traditional Owners of Country throughout Australia and recognises the continuing connection to lands, waters and communities. We pay our respect to Aboriginal and Torres Strait cultures; and to Elders past and present.
New treatment approved for adults with complicated urinary tract infections; Xocova approved for COVID-19 postexposure prophylaxis; investigational diabetic macular edema eye drop fails to meet trial endpoint; Afrezza expanded for pediatric use; obefazimod looks promising for ulcerative colitis.
New triple hormone receptor agonist shows significant weight loss; hepatitis delta virus treatment gains accelerated approval; acne gel gains OTC designation; constipation treatment expanded to include younger patients; and the FDA extends review for camizestrant in advanced breast cancer.
US News and World Report releases their annual best over-the-counter products list; new guidance for drug safety evaluation during pregnancy; gMG indication broadened for efgartigimod; Beqalzi gains accelerated approval for MCL; and a novel treatment fast tracked for ALS.
In this compelling fourth lecture of the series, Acharya das reframes well-being through the lens of timeless wisdom, drawing from sources like the Bhagavad Gita to reveal a powerful three-dimensional model: body, mind, and the often-overlooked spiritual self. With precision and clarity, the talk exposes a universal truth—no amount of success, relationships, or material gain can resolve the subtle but persistent sense of emptiness that many experience. This is not a personal failure or circumstantial issue; it is a signal pointing toward something deeper.The Bhagavad- gītā verse quoted in this talk:In this world, there is nothing so sublime and pure as transcendental knowledge. Such knowledge is the mature fruit of all mysticism. And one who has achieved this enjoys the self within himself in due course of time. - Bhagavad-gītā 4.38Such a liberated person is not attracted to material sense pleasure or external objects but is always in trance, enjoying the pleasure within. In this way the self-realized person enjoys unlimited happiness, for he concentrates on the Supreme. - Bhagavad-gītā 5.21One whose happiness is within, who is active within, who rejoices within and is illumined within, is actually the perfect mystic. He is liberated in the Supreme, and ultimately he attains the Supreme. - Bhagavad-gītā 5.24Chapters00:00:00 Introduction and Three-Dimensional Well-being Paradigm 00:02:22 The Universal Experience of Emptiness and Advertising Manipulation 00:04:38 Personal Counseling Example: Fear of Being Alone 00:06:44 Behavioral Patterns of Avoiding Emptiness 00:08:38 Life Clutter and Hidden Loneliness 00:11:19 Emptiness as Spiritual Protection and Indication 00:13:18 Material Wealth and Relationship Status Don't Eliminate Emptiness 00:15:01 The Inadequacy of the Material World 00:16:37 A Woman's Honest Blog About Emptiness 00:23:47 Attraction to Beauty, Happiness, and Love 00:27:00 The Ice Cream Sundae Metaphor 00:28:52 Spiritual Malnourishment and the Fish Out of Water Metaphor 00:30:31 The Inward Journey and Purpose of Human Life 00:33:07 Bhagavad Gita Verses on Transcendental Knowledge 00:35:56 Liberation Through Spiritual Understanding 00:37:59 The Self-Realized Person's Experience 00:39:30 The Perfect Mystic and Spiritual Attainment 00:41:08 Two Simple Practices: Yoga Wisdom and Meditation 00:42:16 Spiritual Sound and Its Purifying Effects 00:44:15 The Signal of Inner Longing 00:45:41 The Futility of Material Investment 00:46:55 Invitation to Kirtan Practice
Cory talks about how the Carney government would rather sink Canadians further into debt than address the issues hampering the economy.
Two-drug, single-tablet approved to replace current antiretroviral regimen; Dupixent approved for pediatric CSU; novel treatment significantly improves survival in metastatic pancreatic cancer; oral semaglutide for adolescents; GLP-1 Fast Tracked for knee osteoarthritis.
Medicus Pharma CEO Dr Raza Bokhari joined Steve Darling from Proactive to announce that the company has submitted an Orphan Drug Designation application to the U.S. Food and Drug Administration for SkinJect® as a treatment for basal cell carcinoma in patients with Gorlin Syndrome. Bokhari explained that the submission represents a strategic expansion of the SkinJect program into a high unmet-need orphan indication, where current treatment options are limited and often require repeated surgical procedures that can lead to cumulative morbidity and disfigurement. Gorlin Syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare inherited disorder typically caused by mutations in the PTCH1 gene. This leads to dysregulation of the Hedgehog signaling pathway and the development of multiple, recurring skin cancers. Patients may develop dozens to more than 1,000 basal cell carcinomas over their lifetime, often beginning in childhood, creating a significant physical and psychological burden. Currently, there are no FDA-approved therapies specifically for basal cell carcinoma in patients with Gorlin Syndrome, with treatment largely reliant on surgical excision or Mohs surgery. Medicus believes SkinJect® could address this gap through a localized, repeatable, and non-surgical approach. The therapy is a doxorubicin-based dissolvable microneedle array designed for direct intradermal delivery into basal cell carcinoma lesions, targeting tumors at the site while minimizing systemic exposure. The company sees this program as an opportunity to provide a more patient-friendly treatment option for a population with significant unmet medical need. Medicus also noted it has sufficient financial runway into next year to support continued advancement of its clinical programs and key development milestones. #proactiveinvestors #nasdaq #mdcx #tsxv #mdcx #pharma #SkinJect #OrphanDrug #RareDisease #GorlinSyndrome #BasalCellCarcinoma #SkinCancer #Biotech #DrugDevelopment #FDA #Oncology #MedicalInnovation #Healthcare #Microneedle #PatientCare
Join me for look at the orthodontic -periodontal interface, the latest evidence looking at the effects of orthodontic tooth movement as well what periodontal surgery can offer in recession management. This podcast is a summary of Christos Kassaro and Anton Spurrier's excellent lecture, as part of the AngleNet Webinar Series. Timestamp0:44 – At 1-year recession risks of orthodontics 2:30 – At 15-year recession risks of orthodontics4:37 – Retainer relapse: "X" & "Twist" effects5:13 – Biomechanics: Using mixed bracket slots for torque6:17 – Perio surgery principles & donor sites7:54 – Flap designs: Full vs. split-thickness8:14 – Surgical techniques: MCAT vs. LCT9:27 – Timing: Surgery before vs. after ortho?10:33 – Surgical adjuncts: Hyaluronic acid Orthodonticaetiology at 2 time points:1. During active orthodonticmovement 2. During retention phase Kloukos2025 1year follow up study of adult orthodontic patients Vs control · 1 year post debond of non-extractiontreatment at 67% greater incidence of recession within the orthodontic group (IRR = 1.67,95% CI: 1.05, 2.67, P = 0.03). Five main findings:1. Recessionlocation: canines and first premolars, 2. Proclination:incisor proclination of 6.35o with no recession3. Recessionin control group: increased but less than orthodonticgroup4. Recessionquantity: Generally small at 1 mm 5. Reductionin recession for some: Both groups showedsome patients had a reversal of their recession Long term though what do we see?· Gebistorf 2018 Swiss group· At 15 years 77% of orthodonticpatients had 1-14 areas of recession, · Control group who had 62%.· Greater recession on lingual aspectthan labial · 2.73 x more recession with crossbitescorrected (95% CI, 0.28-5.17; P = 0.029) · Crowding in controls: 3 mm = 3.29 x more recessions (95% CI, 0.73-5.68; P =0.012) Orthodontics onaverage does not compromise long term health or function, but may compromise aesthetics Fixed Braided Retainers ‘X'effect (torque) or twist effect (proclination) unwanted movement from wire activation· Not relapsed as new movement · Occurrence: 2.7% (n=221 patients) –Renkema 2011 Treatment‘X' effect 1- Differentialslot side i. Affectedtooth - .18 slot with -17 degrees of torque ii. Remainingteeth.22 slot with 0 torque iii. Sideeffect of intrusion of incisor, due to slot differences Periodontal Surgery concepts:Indication: inadequate gingiva =
He was born in Siberia in 1797 to a clerical family, and became a married parish priest in Irkutsk. A devout explorer, John Kriukov, told him of the great spiritual needs among the Russian and native peoples in Alaska, then Russian territory. Moved to serve Christ in this very difficult environment, he and his family arrived in Alaska in 1824. He quickly learned the Aleut language and worked humbly and tirelessly among the Aleuts. His spiritual classic, An Indication of the Way to the Kingdom of Heaven, was originally written in Aleut and later translated into many languages. While he was visiting Russia in 1838, his wife died; one year later he was tonsured a monk and given the name of Innocent (he had been Fr John Veniaminov). Almost immediately after his tonsuring he was, without warning, raised to the rank of Bishop of all Eastern Siberia and Russian America, probably the largest diocese in the world at that time. Returning to Alaska, he continued his missionary work with vigor, often traveling among Aleut and Tlingit settlements in his own kayak. Wherever he went, he found the Alaskan people hungry for the faith, and his labors bore rich fruit which is still obvious today: Alaska has more Orthodox churches per capita than any other state. In old age he was made Metropolitan of Moscow, head of the entire Russian Orthodox Church. His concern for Christian mission was undiminished, and as Metropolitan he created the Orthodox Missionary Society. He reposed on Holy Saturday of 1879.
A federal court blocks changes to the childhood immunization schedule by the recently appointed vaccine advisory committee; higher dose Wegovy injection gets green light; Cosentyx expanded to include pediatric hidradenitis suppurativa; investigative triple hormone therapy shows significant weight reduction in diabetes.
Pathologists at the inquest into the death of 14-year-old Noah Donohoe have agreed that his cause of death was drowning, with no indication of assault. All three pathologists agreed there was “no positive evidence” of toxicological contribution to Noah's death, but this could not be excluded because of the limitations on toxicological analysis. Liam Tunney joins Olivia Peden. Hosted on Acast. See acast.com/privacy for more information.
Become a YouTube Member and get exclusive Pittsburgh Steelers intel and access to our Discord. Plus much more! https://www.youtube.com/@AllSteelersTalk/membership Join our Patreon for even more Steelers! https://www.patreon.com/cw/NoahStrackbein The Best Steelers Shirts On the Internet! https://blackandgoldapparel.myshopify.com/ Review Our Podcast (Please!): Spotify: https://open.spotify.com/show/4w67Psucw757d4pdH4jBDD?utm_medium=share&utm_source=linktree Apple: https://podcasts.apple.com/podcast/id1627248534?ign-itscg=30200&ign-itsct=lt_p Google: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vc3RlZWxlcnMtdG8tZ28 Everywhere else: https://linktr.ee/allsteelerstalk Follow Our Socials: TikTok: https://www.tiktok.com/@allsteelerstalk?lang=en Instagram: https://www.instagram.com/allsteelerstalk/ Twitter: https://twitter.com/AllSteelersFN Facebook: https://www.facebook.com/AllSteelers Learn more about your ad choices. Visit megaphone.fm/adchoices
Become a YouTube Member and get exclusive Pittsburgh Steelers intel and access to our Discord. Plus much more! https://www.youtube.com/@AllSteelersTalk/membership Join our Patreon for even more Steelers! https://www.patreon.com/cw/NoahStrackbein The Best Steelers Shirts On the Internet! https://blackandgoldapparel.myshopify.com/ Review Our Podcast (Please!): Spotify: https://open.spotify.com/show/4w67Psucw757d4pdH4jBDD?utm_medium=share&utm_source=linktree Apple: https://podcasts.apple.com/podcast/id1627248534?ign-itscg=30200&ign-itsct=lt_p Google: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vc3RlZWxlcnMtdG8tZ28 Everywhere else: https://linktr.ee/allsteelerstalk Follow Our Socials: TikTok: https://www.tiktok.com/@allsteelerstalk?lang=en Instagram: https://www.instagram.com/allsteelerstalk/ Twitter: https://twitter.com/AllSteelersFN Facebook: https://www.facebook.com/AllSteelers Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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Five articles from the February 2026 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles this month are: Intraoperative Zoledronic Acid for Arthroscopic Rotator Cuff Repair: Short-Term Results From a Prospective, Randomized, Placebo-Controlled Phase II Trial Dermal Allograft Augmentation for Open Gluteus Medius Repair: A Case Series at 2-Year Follow-up Prediction of Contralateral Patellar Instability After Ipsilateral Medial Patellofemoral Ligament Reconstruction Arthroscopic Primary Labral Reconstruction in the Hip: Minimum 10-Year Outcomes With a Nested Propensity-Matched Control Using a Residual Pivot Shift as the Indication to Perform a Lateral Extra-articular Tenodesis During ACL Reconstruction Using Autologous Hamstring Grafts Is Associated With Improved Surgical Outcomes: A Retrospective Review of 4755 Cases Click here to read the articles.
Few surgeons in the world combine the depth of clinical experience and academic rigor that Dr. Waldemar Polido brings. A Professor and practicing Oral Maxillofacial Surgeon in Indianapolis, he began his dentistry education in Brazil and has since built a career at the forefront of complex implant surgery. In this conversation, Dr. Polido shares his three-part implant philosophy, systematic surgical approach, and the evolution of solutions for patients with severe maxillary atrophy. We also explore common surgical complications, strategies for prevention, grafting techniques, and the post-operative processes that ensure long-term success. Packed with insights from a highly experienced and knowledgeable guest, this episode is essential listening for oral maxillofacial surgeons seeking to expand their mastery of zygomatic implants.Key Points From This Episode:Dr. Polido's education, surgical residency, and academic background.His three-part philosophy on implantology as influenced by Brånemark. Four systematic concepts that support his approach to long-lasting implants. How Dr. Polido's approach towards determining which solution to use has evolved. Reducing complications during zygomatic implant surgery.Where grafting typically comes in during the implant process.Post-op processes for pain control and follow-up. Foreseeing and addressing complications during surgery. Advice on how oral maxillofacial surgeons can learn more about zygomatic implants.Predictions for the next 15 years of implant dentistry.Rapid fire questions: Dr. Polido's best read of the past year and more. Links Mentioned in Today's Episode:Dr. Waldemar Polido on LinkedIn — https://www.linkedin.com/in/waldemardpolido/ Dr. Waldemar Polido on Instagram — https://www.instagram.com/prof.waldemarpolido/ Dr. Waldemar Polido Email — wdpolido@iu.edu Dr. Per-Ingvat Brånemark — https://www.branemark.se/branemarklegacy Indiana University School of Dentistry — https://www.dentistry.iu.edu/ The SAC Classification in Implant Dentistry — https://www.iti.org/the-sac-classification-in-implant-dentistry ZAGA Centers — https://zagacenters.com/ Dr. Carlos Aparicio — https://www.apariciozygomatic.com/ E. Armand Bedrossian on LinkedIn — https://www.linkedin.com/in/e-armand-bedrossian-dds-msd-facp-7752b8184/ Pikos Institute — https://www.pikosinstitute.com/ Complexitiez — https://www.complexitiez.com/ AAOMS — https://aaoms.org/ All Physicians Lead — https://www.amazon.com/All-Physicians-Lead-Redefining-Leadership/dp/B0CN2RG5F7 Do You Feel Like I Do? — https://www.amazon.com/Do-You-Feel-Like-Memoir/dp/0316425311 Landman — https://www.imdb.com/title/tt14186672/F1: The Movie — https://www.imdb.com/title/tt16311594/ Adolescence —
From ginger shots and lentil crisps to sparkling bone broth and cinnamon water, the hosts hit the floor at 2026 Winter FancyFaire* in San Diego to sample what's next in food and beverage. The hosts discuss standout brands, innovative concepts, smart packaging and evolving brand strategies that reveal where wellness, snacking and functional drinks are headed. Show notes: 0:25: Toll Booth. Talk On Camera. Ginger Boost. Cravable Crisps. New Jerk. Bone Broth What? Chips & Cherries. – At the Taste Radio booth at the 2026 Winter FancyFaire* in San Diego, the hosts highlight Elevator Talk interviews recorded at the show and praise the event's energy, accessibility, and balance of early-stage and established brands. They also spotlight trends like functional wellness, clean-label snacks, and innovative packaging. They sip on Solti's turmeric and ginger shots, before snacking on Paro's new lentil crisps and discussing the brand's move into more mainstream offerings. The hosts also sample Pulpito's new fruit bars, and Morro's unconventional sparkling bone broth. They also feature standouts products, from a portable squeeze-pack peanut butter and Indian-inspired coffee drinks to better-for-you popsicles, cinnamon-infused water, and a variety of functional and indulgent snacks. Brands in this episode: Solti, Starbucks, Paro, Maazah, Masala Bliss, Pulpito, Solely, Marro, By Nutz, Yeri, Dew Dropper, Rabbit Foods, Tru Cinnamon, Burlap & Barrel, Bitchin' Sauce, The Coconut Cult, Tart, Cheribundi, Todo, Date Better, Baba's, Habiza, Dirty Saint
Midweek Check-in.
KMOX Religion Editor Fred Bodimer chats with Pew Senior Researcher Greg Smith about religion and young people in the United States.
In this episode of K9's Talking Scents, Cameron Ford sits down with world-renowned trainer Michael Ellis for one of the most in-depth conversations ever recorded on reinforcement theory, over-arousal, odor commitment, reward schedules, and why many detection dog programs unintentionally create false alerts.Together they break down the problems behind “reward-rich” training systems, how reinforcement can become punishing, why omission matters, and how to build dogs who persist, stay committed to odor, and search with accuracy — even in operational environments where rewards rarely come.This episode covers:• Why dogs become toy-obsessed instead of odor-committed• How handlers accidentally create false alerts• Why “continuous reinforcement” destroys operational reliability• Rewarding search vs rewarding finds• The science of frustration, dopamine, and over-performance• The difference between learning behavior and maintaining behavior• Why real-world deployments MUST be represented during training• How to introduce blanks, variable schedules, and expectation violation• "Satan's Infinite Loop" and how trainers build bad habits into dogs• Why many dogs don't indicate because they want the search to continue• How to build persistent, reliable, stable detection dogsIf you're a detection dog handler, trainer, supervisor, or K9 program manager, this is a masterclass.CHAPTERS00:00 — Intro & catching up01:00 — Online education & training libraries02:00 — Are rewards harming performance?05:00 — Reinforcement vs intrinsic motivation07:00 — Over-arousal in detection dogs08:30 — Searching for toys vs searching for odor10:00 — False alerts & frustration12:00 — The “cheat code” problem14:30 — Reward-rich environments vs real deployments17:00 — Continuous vs variable reinforcement19:00 — Training that mirrors real-world operations21:30 — Expectation violation & handler discomfort23:00 — Why easy training creates weak dogs26:00 — Dogs that quit vs dogs that persist28:00 — Reducing rewards without breaking the dog30:30 — Reading search behavior correctly32:00 — Consistency in training fundamentals35:00 — Foundation errors that create future problems38:00 — When to introduce blanks41:00 — Reinforcing end-of-search behaviors44:00 — Fixing continuously rewarded dogs47:00 — Why dogs miss the first odor49:00 — Over-arousal & compensation behaviors52:00 — Indication obsession & unintended consequences54:00 — Odor recognition vs sit/down behavior57:00 — Natural indications & reading the dog59:00 — Satan's Infinite Loop explained________________________________________
AMJ Podcast | Episode 4 Capivasertib in the Clinic: Strategies to Manage Adverse Events This content was funded by AstraZeneca, and is intended for US Healthcare Professionals. Expert opinions are shared in this program and may differ from the approved capivasertib (TRUQAP®) labeling. Please see full Prescribing Information, including Patient Information when making treatment decisions. Indication and Usage Capivasertib (TRUQAP®) in combination with fulvestrant is indicated for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN alteration as detected by an FDA-approved test following progression on at least one endocrine-based regimen in the metastatic setting or recurrence on or within 12 months of completing adjuvant therapy. Description In this practical, case-based discussion, a breast oncology pharmacist and nurse practitioner walk through how they anticipate and manage the most common adverse events seen with capivasertib in HR-positive/HER2-negative advanced breast cancer. Drawing on real-world clinic workflows, they share stepwise approaches to counseling, prophylaxis, and early intervention for diarrhea, rash, and hyperglycemia, including when to escalate monitoring or treatment and how to coordinate roles across the care team. You'll hear communication scripts, tips for using tools such as stool diaries and home glucometers, and strategies to keep patients on therapy safely and confidently. Chapters 00:00 – 03:24 | Introduction 03:24 – 05:18 | When to consider capivasertib 05:18 – 08:51 | Introducing adverse events 08:51 – 16:18 | Diarrhea management 16:18 – 20:35 | Rash management 20:35 – 25:07 | Hyperglycemia management 25:07 – 27:31 | Care team best practices 27:31 – 31:18 | Top Tips & Takeaways Speakers: Heather Moore – Breast Oncology Pharmacist, Duke University Medical Center Sarah Donohue – Breast Oncology Nurse Practitioner, UCSF Health Breast Care Center Select Safety Information About capivasertib (TRUQAP®) tablets TRUQAP is contraindicated in patients with severe hypersensitivity to TRUQAP or any of its components. Serious adverse reactions include hyperglycemia, including diabetic ketoacidosis and fatal outcomes; diarrhea; and cutaneous adverse reactions. Monitor fasting glucose and hemoglobin A1C levels regularly. May cause fetal harm when administered to a pregnant woman. Among the 355 patients who received TRUQAP in CAPItello-291, the most common (≥20%) adverse reactions, including laboratory abnormalities, were diarrhea (72%), cutaneous adverse reactions (58%), increased random glucose (57%), decreased lymphocytes (47%), decreased hemoglobin (45%), increased fasting glucose (37%), nausea and fatigue (35% each), decreased leukocytes (32%), increased triglycerides (27%), decreased neutrophils (23%), increased creatinine (22%), vomiting (21%), and stomatitis (20%). Please see full Prescribing Information, including Patient Information for TRUQAP.
Modi's Big Indication - Action on Mu$lims & Isl@m to Begin | Amit Shah in Action Mode |Sanjay Dixit
The FDA requests boxed warnings be removed from HRT product labels; Caplyta approved for MDD; Darzalex Faspro gains new indication; investigational MS treatment looks promising; trial investigates simplified HIV regimen.
TJ Lateef's first game as a starting QB was excellent----he really didn't look rattled at any time, and led 4 TD scoring drives, plus the impressive drive to close the game out. 13/15 passing , 205 yards, 3 TDs (no INTs or fumbles); 5 carries, 31 yards You can't say after one game that he's the guy of the future---what you can say is that he goes to Penn State and wins and is a big reason why and they beat Iowa as well…then it HAS to get interesting at that spot. That's drama that should be welcomed. Show Sponsored by MIDWEST BANKOur Sponsors:* Check out Avocado Green Mattress: https://avocadogreenmattress.com* Check out Hims: https://hims.com/EARLYBREAK* Check out Infinite Epigenetics: https://infiniteepigenetics.com/EARLYBREAK* Check out Uncommon Goods: https://uncommongoods.com/EARLYBREAK* Check out Washington Red Raspberries: https://redrazz.orgAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Dr. Francis Marchlinski, Deputy Editor of JACC: Clinical Electrophysiology, discusses Electrode Thermal Profile During Ventricular RF Ablation: A novel indication to potentially inform energy delivery.
Our Browns beat reporter Daryl Ruiter joined "Baskin and Phelps" Thursday, and gives the state of the Browns with the Steelers game in Pittsburgh coming up in three days, along with why talks of a "fire sale" coming in Cleveland is not the case.
Welcome to this special episode of the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. For major FDA decisions in the field of neurology, we release short special episodes to offer a snapshot of the news, including the main takeaways for the clinical community, as well as highlights of the efficacy and safety profile of the agent in question. In this special edition of Mind Moments, Patricia Pozo-Rosich, MD, PhD, head of the neurology department at Vall d'Hebron University Hospital, discussed the recent FDA approval of fremanezumab (Ajovy) for pediatric migraine prevention. As a study author on the pivotal phase 3 SPACE trial (NCT03539393), Dr. Pozo-Rosich reflected on the significance of having a proven therapeutic option in a population where placebo responses and lack of evidence have long complicated care. She provided insights on how the trial was designed and the challenges of running pediatric studies, particularly in adolescents. Additionally, she highlighted broader implications for migraine research, including efforts to reduce placebo effects, the role of CGRP pathway inhibition in younger patients, and the future promise of emerging targets such as PACAP antagonists and new toxin formulations. For more of NeurologyLive's coverage of fremanezumab's expanded indication in pediatric migraine, head here: FDA Approves Fremanezumab as First Anti-CGRP Preventive Therapy for Pediatric Episodic Migraine Episode Breakdown: 1:10 – Initial reaction to fremanezumab approval and significant for pediatric migraine care 6:05 – Major clinical insights and takeaways from phase 3 SPACE trial 10:20 – Challenges in pediatric migraine trials and addressing high placebo responses 15:10 – Future directions in migraine therapy, including PACAP-targeting drugs and novel approaches Thanks for listening to the NeurologyLive Mind Moments podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
"McElroy & Cubelic In The Morning" airs 7am-10am weekdays on WJOX-94.5!See omnystudio.com/listener for privacy information.
Listen to a conversation with Durand Jones, Aaron Frazer and Blake Rhein of the soul band Durand Jones and The Indications. They joined WFYI's Kyle Long for an in-depth discussion of their roots in Bloomington, Indiana and how projects including the IU Soul Revue and Charlie Patton's War brought the band together. The Indications' latest album is titled “Flowers”, and they'll be performing in Indianapolis on September 30 at the Hi-Fi Annex. Durand Jones and the Indications formed in Bloomington in 2012, while its members were studying at Indiana University. The band's sound was built around a mutual love for classic soul, funk and R&B. Their reputation spread beyond Bloomington in 2016, when Ohio's Colemine Records issued their debut album. The Indication's second album “American Love Call” was issued in 2019 and praised by critics for its lush arrangements and socially conscious lyrics, earning comparisons to The Impressions and The Delfonics. Two years later, their album “Private Space” debuted in the Top 10 of Billboard's Emerging Artists chart. Their latest album “Flowers” builds on the band's distinct blend of vintage soul sounds and contemporary production techniques. Since launching in Bloomington over a decade ago, The Indications have grown into an international force, racking up millions of streams online, and touring across North America and Europe.
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Hear Christopher McKim's journey with moderate to severe plaque psoriasis and the latest clinical trial results from dermatologist, Dr. Christine Cornejo. Join this discussion with moderator Archie Franklin as Christopher McKim, a BMS employee living with moderate to severe plaque psoriasis, and Dr. Christine Cornejo, Director and US Medical Engagement Lead for Dermatology and Rheumatology at BMS, offer a patient and physician's perspective on treating plaque psoriasis from the inside. Listen as Chris presents his journey along with Dr. Cornejo addressing effectiveness and safety information with clinical trial results for a prescription oral treatment option. The intent of this episode is to encourage those who have moderate to severe plaque psoriasis to work with their health care provider to find a treatment option that is right for them. This episode is sponsored by Bristol Myers Squibb. For more information view Full Prescribing Information and Medication Guide . · (0:00) Intro to Psoriasis Uncovered and guest welcome to Bristol Myers Squibb employee and patient Christopher McKim and Dr. Christine Cornejo, Director and US Medical Engagement Lead for Dermatology and Rheumatology at Bristol Myers Squibb. · (2:15) Where the journey to finding the right treatment option for Chris and his moderate to severe plaque psoriasis began. · (3:09) The decision by Chris and his provider to try an oral systemic medication. · (3:28) The effects and impact of an oral systemic treatment for Chris and his plaque psoriasis. · (4:09) Dr. Cornejo addresses efficacy and clinical trials results. · (5:58) Common side effects and safety concerns for the treatment Chris and his health care provider decided to try. · (6:28) Health considerations patients and providers should discuss prior to using a systemic treatment. · (6:54) What to do should side effects occur. · (7:10) How Chris feels with clearer skin after making a change in treatment. · (8:14) Indication and Important Safety Information. Key Takeaways: · Moderate to severe plaque psoriasis is a systemic disease. · If you're ready to treat from the inside there is a treatment option that may help. · Work with a health care provider to find the right treatment for moderate to severe plaque psoriasis. · Be proactive by taking steps to learn about treatment options including effectiveness, side effects, safety concerns, and what should be discussed with a health care provider before beginning a new treatment for plaque psoriasis. Guest Bios: Christopher (Chris) McKim joined BMS in June of 2022. In his current role he is a Regional Marketer for the dermatology division, prior to that he provided support for 9 Therapeutic Area Specialists for the Pacific South District in the GI division. Prior to joining BMS, Chris worked at Sanofi, J&J, Leo Pharma, and Sun Pharma in various field and home office roles. Chris resides in beautiful San Diego with his family Susan (wife), Morgan 18, Maddy 16, Mason 14 and two Golden Retrievers and enjoys traveling, cooking and anything associated with the ocean (Deep Sea Fishing, S.C.U.B.A. diving, snorkeling, and boogie boarding). Dr. Christine Cornejo joined Bristol Myers Squibb in 2024 as Director, Medical Engagement Lead for Dermatology and Rheumatology. Prior to joining BMS, she practiced dermatology at Brigham and Women's Hospital and Dana-Farber Cancer Institute in Boston, MA, where she specialized in melanoma and high-risk skin cancer management and served as the Director of Confocal Microscopy. She also served as an Instructor at Harvard Medical School and led the Immunology and Infectious Diseases course for 1st year medical students. Resources: Current Oral Systemic Treatments For additional questions about treatment options contact the NPF Patient Navigation Center
Mike Johnson, Beau Morgan, and Ali Mac continue the final hour by spending some time with 92.9 The Game's own Braves insider and reporter, Grant McAuley! Beau, Mike, Ali, and Grant discuss if Grant thinks the Braves could trade Sean Murphy at the trade deadline, what Grant expects from the Braves after the All-Star break, how Grant felt about Spencer Strider's start last night, Grant Holmes putting together a really good 2025 season, Grant Holmes not getting any run support this season, what Grant is most excited about for All-Star Weekend here in Atlanta, and who Grant is looking forward to talking to the most out of all of the 2025 MLB All-Stars.
Matthew 25:31–46
Phil Steele top 60 has Utah at #18 and BYU at #53 60 in 60 Watchlist - Broc Lane - USU TE | Good, Bad & Ugly Whole World News
We are less than two weeks away from the start of Thom's Australia visit. We have a range of tour events scheduled, including free introductory talks and a learn to meditate course for those who are new to Vedic Meditation. If you've completed a qualified Vedic Meditation course, we invite you to join Tom for knowledge sessions, group meditations and a one-day retreat he has scheduled in Sydney. Thom is also offering a five-day four-night retreat in Gerringong, south of Sydney, as well as private mentoring sessions throughout the month. You can find out more about all of these offerings at thomknoles.com/sydney. Detachment is frequently sold as a necessary step for spiritual progress. We're taught that attachment is often the root of our suffering, so it stands to reason therefore, that detachment will bring about the opposite of suffering.But as Thom explains in this podcast episode, it's an understandable yet inaccurate conclusion that actually causes more suffering.Thom brings clarity to the subject, using the Vedic concept of vairagya, a state of being that allows us to fully enjoy the fruits of life, without the bondage of attachment.Episode Highlights[00:45] Maharishi Patanjali's Yoga Sutras[02:56] Siddhis - Developing Extraordinary Human Capabilities[05:36] A Spontaneous State of Non-attachment[09:48] A Witnessing Phenomenon[12:55] A Consequence of the Practice of Vedic Meditation[16:23] An Indication of Cosmic Consciousness[19:08] The Freedom of Spontaneous Non-attachmentUseful Linksinfo@thomknoles.com https://thomknoles.com/https://www.instagram.com/thethomknoleshttps://www.facebook.com/thethomknoleshttps://www.youtube.com/c/thomknoleshttps://thomknoles.com/ask-thom-anything/
Sources are telling CNN that authorities have executed as many as three search warrants in New York as part of their investigation into the killing of UnitedHealthcare CEO Brian Thompson. At least two of the warrants include the backpack found in Central Park and the burner phone found near where the shooting occurred, according to a law enforcement source with knowledge of the investigation. Anderson shares what we have learned so far, and what we still don't know about the suspect. Plus, what the White House said today about the mysterious drones flying at nighttime over many parts of New Jersey. Learn more about your ad choices. Visit podcastchoices.com/adchoices