Podcasts about Adiponectin

It seems like almost everyone is taking GLP-1 medications these days to lose weight. Now a couple years after they've been used for this purpose, what do we know? How do we interpret all the headlines about them? Despite how the news makes it sound and what your doctor may have told you, you have options! Tune in to understand more about GLP-1 medications, what Jenn does as a health coach for her clients who are taking them, and how you can naturally support your own GLP-1, empowering you with knowledge and control over your health.Welcome to Salad with a Side of Fries! In today's episode, Jenn dives into the impact of GLP-1 medications on metabolic health. She begins by explaining what GLP-1 is and addresses some of the controversy surrounding celebrities who don't admit to using it for their weight loss. Jenn also uncovers how the secondary benefits of GLP-1 often mislead the public and explores its short term side effects and potential long lasting impacts. She discusses the concept of fat cells having memory, what people can do to support true metabolic health while taking these meds, and shares practical tips for naturally supporting your body's own GLP-1 for long term metabolic health. The Salad With a Side of Fries podcast is hosted by Jenn Trepeck, discussing wellness and weight loss for real life, clearing up the myths, misinformation, bad science & marketing surrounding our nutrition knowledge and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store. IN THIS EPISODE: (00:00) Jenn talks about GLP-1 meds, metabolic health and weight loss(05:07) Defining GLP-1 and how it works in the body(12:05) How the public is misled by the secondary benefits of taking the medication and discussion of side effects(21:08) Being cautious and a discussion of the gut brain connection and malnutrition(26:50) Fat cells have memory, BMI as a metric, and an example of how the Healthy Vibe Tribe brought down blood sugar 70 points for a client(35:10) How to naturally support your GLP-1 and metabolic health(43:53) What about insulinKEY TAKEAWAYS: GLP-1 medications are more openly discussed with more people openly admitting they're taking them. This shift contrasts with the early days when celebrities falsely claimed weight loss was solely due to light exercise, misleading the public and creating unrealistic expectations for weight loss.Jenn criticizes the Super Bowl ad from Hers, which she believes "weaponized diet culture" to promote its version of a GLP-1 medication. She expresses frustration with how marketing continues to exploit societal insecurities around weight, comparing it to the more positive and empowering approaches taken by brands like Dove.While GLP-1 medications can be life-transforming in the short term—reducing weight and alleviating joint pain—there are concerns about their long-term impact. Issues like bone density loss, muscle deterioration, and potential joint problems down the line should be considered. This highlights the importance of being proactive and responsible for your long-term healthWhile taking the medications may seem like the “easy button,” there are other considerations to ensure true health, like the nutrition you provide your body when you do eat and the role supplementation can play. There are nutrition and supplementation choices that can support the body's own GLP-1 production.QUOTES: (04:55) “GLP stands for Glucagon Like Peptide. Glucagon Like Peptide 1 comes from the large bowel, or the colon. It stimulates insulin secretion, suppresses glucagon, supporting blood sugar regulation.” Jenn Trepeck(17:21) “Protein and fiber at every meal makes removing fat, no big deal.” Jenn Trepeck(34:54) “Sometimes while we think this is the easy button, it requires an even more significant commitment to protein, fiber, quality fat, strength training, and a multivitamin to get your micronutrients.” Jenn Trepeck.(40:23) “When we start to understand low glycemic impact nutrition, we're focusing on nutrient dense foods and less processed foods.” Jenn Trepeck(42:35) “ Exercise, sleep, water, food. Those are your responsibilities. ” Jenn TrepeckRESOURCES:Jenn's GLP-1 Support SupplementsBecome A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nugget: Ozempic Your Fat Cells Have Memory, A New Study Finds (feat. Ferdinand von Meyenn) BMI Is BSNutrition Nugget: ButterThe Ultimate BiohackTop 5 Tips for Digesting Nutrition News

Do you struggle to lose weight and keep it off? It turns out, fat cells actually have a memory that can keep weight off after rapid weight loss!In this episode of Salad with a Side of Fries, Jenn Trepeck sits down with Professor Dr. Ferdinand von Meyenn, assistant professor at the Institute of Food, Nutrition, and Health at ETH Zurich, to explore his study with the intriguing finding that fat cells encode a memory which influences the ability to maintain weight loss and therefore impacts metabolic health. They delve into his groundbreaking research on bariatric patients and mice, uncovering how fat cells retain memory and can continue to impact the body long after weight loss. Dr. von Meyenn breaks down the role of epigenetics, why GLP-1 medications don't provide long-term effects, and the importance of proper nutrition and lifestyle when losing weight and keeping it off. They also discuss the hip-to-waist ratio versus BMI and why prevention is the most powerful tool for long-term well-being. The Salad With a Side of Fries podcast is hosted by Jenn Trepeck, discussing wellness and weight loss for real life, clearing up the myths, misinformation, bad science & marketing surrounding our nutrition knowledge and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store. IN THIS EPISODE: (05:27) Ferdinand's research on fat cell memory and metabolic health(09:21) Research findings on bariatric patients and experiments on mice(17:28) Ferdinand defines epigenetics and GLP's don't give long-lasting effects(26:06) Losing weight too quickly and the set point concept(35:00) Weight loss is good, but proper nutrition is critical and discussion of adiponectin(38:27) Excess energy and body fat, the hip to waist ratio, and being overweight, and the long-term consequencesKEY TAKEAWAYS: Even after significant weight loss, an individuals' fat cells retain molecular changes (altered RNA and epigenetic markers) associated with their previous obese state. These long-lasting molecular markers in the fat cells predispose the body to regain weight as it responds more readily to an obesogenic environment.Weight loss significantly improves health, whether in humans or mice. However, fat cells have a form of memory, meaning that even after weight loss, some molecular changes persist. While these changes do not necessarily drive disease, they highlight the importance of sustained weight management strategies.Rapid weight loss, especially with methods like GLP-1 medications, can lead to muscle loss, negatively impacting metabolism and overall health. Since muscles play a key role in energy expenditure and physical stability (especially with aging), preserving muscle mass during weight loss is crucial for long-term success and well-being.QUOTES:         (06:59) “Many times people get bariatric surgery, and despite that being a very significant intervention that restricts how much food you take in, people lose weight for a while, and yet some recover some of that body weight.” Ferdinand von Meyenn(13:46) “The cell predisposes these people to regain weight because their cells are signaling for the obesogenic environment that they became used to.” Jenn Trepeck(24:53) “I think this is connected to the set point idea that people have heard of how we go about ‘losing the weight'. That might play into this too.” Jenn Trepeck.(26:08) “If weight loss is too quick, it is also loss of protein mass, basically of muscle mass and that is really problematic.” Ferdinand von Meyenn(32:43) “If we build lean muscle mass over time, removing fat over time, giving the body time to adapt to this metabolically healthier environment, there's the possibility of easier maintenance.” Jenn TrepeckRESOURCES:Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nugget: Minnesota Starvation ExperimentGUEST RESOURCESLaboratory of Nutrition and Metabolic Epigenetics - WebsitevonMeyenn BlueSky - Social MediavonMeyenn Lab BlueSky - Social MediaMeyenn lab -  XFerdinand - XFerdinand von Meyenn - LinkedInGUEST BIOGRAPHY: Ferdinand von Meyenn has been Assistant Professor of the Institute of Food Nutrition and Health at the ETH Zurich since January 2019.Ferdinand studied Biochemistry at the TU Müchnen, Germany, before moving to ETH Zürich for his PhD to study metabolism and type-2 diabetes. After graduating, he joined Prof Wolf Reik at the Babraham Institute in Cambridge, UK, investigating epigenetic mechanisms during development and ageing. In 2017 he joined King's College London as a Group leader and Research Fellow. Then, in 2019, he moved to ETH Zurich, where he was appointed Assistant Professor of Nutrition and Metabolic Epigenetics. His research focuses on the relationship between nutrition, metabolism and the epigenome, aiming to contribute to developing novel strategies to combat obesity and metabolic disease.

Imagine being able to foresee and address metabolic health risks before they manifest into chronic diseases. In this episode, Dr. Ritamarie explores how genetic testing can be helpful in identifying potential metabolic imbalances, from insulin resistance to carbohydrate sensitivity and use these to personalize healthful eating plans. Discover how specific genetic SNPs influence blood sugar regulation, insulin sensitivity, and fat metabolism. Whether you're a health practitioner or a self-healer, this episode will revolutionize the way you approach personalized health care.What's Inside This Episode?Genetics as a Predictive Tool: How understanding certain SNPs can reveal hidden metabolic risks and be used to personalize plans.Practical Applications: How to integrate genetic insights with lab testing for personalized dietary and lifestyle strategies.The Sweet Tooth Gene and Beyond: Explore key SNPs affecting blood sugar, insulin resistance, and weight management.Fasting Protocols: The role of fasting mimicking diets in optimizing metabolic health safely and effectively.Actionable Lab Testing Tips: What markers to test for a comprehensive metabolic health assessment.Links & ResourcesDownload our FREE Guide to Using Genetic Testing to Optimize Patient OutcomesReferences to GLUT2 gene?Video for Adiponectin?Find out more about our Insulin Resistance Mastery Program for Practitioners here.Join the Next-Level Health Practitioner Facebook Group for free resources and community support.Get the replay and slides from our most recent summit for practitioners, ReInvent 2025 here, a deep dive into the impact of the microbiome, lab Visit INEMethod.com for advanced practitioner training and tools to elevate your clinical skills.Learn more about The Lab Testing Gaps That Are Sabotaging Your Client's Health found in this episode.

What if a little-known plant protein held the key to longevity, metabolic health, and neuroprotection? In this eye-opening episode of Super Life, Darin Olien dives deep into the groundbreaking science of Osmotin and Adiponectin, two compounds that play a critical role in energy balance, fat metabolism, and overall cellular health. You may have never heard of these before, but they could be the missing link to optimizing your body's natural healing mechanisms. Darin breaks down how these molecules function, their role in insulin sensitivity, inflammation reduction, and cognitive function, and why they are essential for anti-aging and disease prevention. If you care about longevity, fat loss, and brain health, this episode is a must-listen! We Also Discuss: (00:00:00) Introduction – What You Need to Know About Osmotin & Adiponectin (00:02:31) Why Haven't You Heard of These Powerful Compounds? (00:03:09) How Plants Produce Osmotin and Why It Matters for Human Health (00:05:03) Adiponectin's Role in Fat Burning, Insulin Sensitivity, and Energy Balance (00:07:17) The Shocking Link Between Osmotin and Longevity (00:09:40) Why Adiponectin Levels Decline as You Age—And How to Fix It (00:12:13) The Connection Between Osmotin, Metabolism, and Weight Management (00:14:52) How Osmotin and Adiponectin Influence Brain Health & Neuroprotection (00:17:36) The Anti-Inflammatory & Cardiovascular Benefits of These Compounds (00:20:19) How Whole Foods Boost Adiponectin and Improve Your Metabolism (00:22:48) Practical Ways to Increase These Longevity Compounds Naturally (00:25:35) Final Takeaways & How to Implement This Knowledge Today Thank You to Our Sponsors: Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Tru Niagen: Backed by Nobel Prize-winning science, this NAD+ booster is essential for aging well. Use code DARIN20 for 20% off at truniagen.com. Find More From Darin: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Key Takeaway: "Science is finally catching up with nature. Osmotin and Adiponectin are proof that what we eat and how we live can unlock the body's most powerful healing pathways."

Today, Dr. O'Mara is the only physician in the world specializing in health and performance optimization. He works with individuals and corporations interested in the biological optimization of humans through innovation and safe, natural lifestyle strategies shown to be more effective than medications. He especially enjoys working with exceptionally motivated individuals such as business executives, professional performers, and athletes whose livelihoods are predicated upon performance. In 2016, he was awarded a $1.2 million grant from the National Science Foundation for research on reversing chronic disease using innovative biomarkers such as visceral and pericardial fat. Instagram: https://www.instagram.com/drseanomara Twitter: https://x.com/DrSeanOMara YouTube: https://youtube.com/@drseanomara Other: https://www.growingbetternotolder.com/links Website: https://drseanomara.com/ Timestamps: 00:00 Trailer. 00:53 Introduction. 04:21 Visceral fat as a better marker. 08:08 Abdominal diameter indicates visceral fat. 12:03 Adiponectin benefits health but hides six-packs. 15:36 Facial changes and fat. 17:53 Facial indicators of health. 22:15 Visceral fat reduction improved health outcomes. 23:08 Epicardial and visceral fat increase risks of AFib. 28:18 Visceral fat is bad. 29:03 Grass-fed beef has higher omega-3 content. 33:28 Sprinting reduces visceral fat. 38:05 Sprinting safety. 43:42 Hills improve sprinting technique and safety. 46:29 Intense exercise and stress elimination reduce fat. 48:36 Heart fat reduces fastest, then visceral fat. 51:47 Where to find Sean. See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation   #humanfood #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree  ‪

Episode 179: Impact of intermittent fasting Impact on T2DMFuture Dr. Carlisle explains the physiology of fasting and how it can help revert type 2 diabetes. Dr. Arreaza adds details on how to do intermittent fasting. Written by Cameron Carlisle, MSIV, Ross University School of Medicine. Comments and edits by Hector Arreaza, MD, FAAFP.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.What is type 2 Diabetes Mellitus (T2DM)?-Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and impaired glucose regulation. -This impaired regulation can lead to hyperglycemia, contributing to complications in a myriad of organs: heart, kidneys, eyes, nerves, etc. (target organs). According to the CDC, more than 38 million Americans have T2DM (about 1/10 people). -Multiple mechanisms are believed to contribute to insulin resistance in obese patients with T2DM, such as increased lipid deposition throughout the body and systemic inflammation.What is Intermittent Fasting (IF)? Intermittent fasting (IF) has recently gained popularity as a dietary approach for health benefits, but it has been around for thousands of years. IF is an eating pattern that alternates between eating and fasting (no calories consumed) over a specific period of time. When you are fasting, you are allowed and encouraged to keep drinking water and non-caloric drinks, like coffee, tea, and even homemade bone broth.-According to the International Food Information Council Foundation (IFIC), 10% of Americans engage in IF daily. -According to Mark Mattson, a neuroscientist and IF expert for over 25 years, a mechanism called “metabolic switching” is seen with IF. This is when your body runs out of glucose and starts burning fat (i.e., fatty oxidation). These metabolic changes can help protect your organs and reduce the risk of chronic conditions, like T2DM. Common IF methods: Time-restricted eating: Most common method, involves eating within a specific time frame (e.g., the 16:8, 18:6, 12:12 method is also common.  [16:8 means you have 16 hours of fasting and 8 hours of eating.]Alternate-day fasting: Alternating between fasting days and normal eating days.  [Find more info in The Complete Guide to Fasting, by Jason Fung, who is a nephrologist, he explains that alternate-day is basically eating every other day, which would give 36 hours of fasting, but if you are a beginner you can try a 24 hours fasting, in short, not eating breakfast any day of the week and having lunch 4 days a week, and dinner every night.]5:2 diet (aka periodic fasting): Maintaining a normal diet for 5 days, with 2 days (usually non-consecutive) of caloric restriction (25% of normal caloric intake; e.g., 500 calorie meal). IF is strongly believed to improve metabolic health in individuals with T2DM by reducing insulin resistance via increasing insulin sensitivity, promoting weight loss (patients with obesity and DM… AKA patients with diabesity), and enhancing lipolysis via fat oxidation.While fasting, the body goes through several phases that affect how energy is metabolized. Between 0 and 4 hours after eating, the body enters a feeding state, using glucose as its main energy source. After fasting for 12-16 hours, the body enters ketosis and starts to use fat for energy. Within 24-36 hours, autophagy begins, a process that recycles damaged cells and allows for cellular repair. This process can have great benefits for people with T2DM, such as improved insulin sensitivity and glucose regulation. Pathophysiology of Implementing IF in T2DM. -IF is thought to increase insulin sensitivity by decreasing fatty tissue in the body (i.e., visceral adipose tissue), which is correlated to insulin resistance. Insulin resistance is defined as higher than normal circulating insulin levels needed for a glucose lower response, which is thought to be the culprit for the generation of T2DM. It means you need high levels of insulin to keep glucose normal. -Obesity is an important risk factor for T2DM. Visceral adipose tissue functions as an organ via the secretion of adipokines (cytokines or cellular messengers produced by adipose tissue): leptin and adiponectin. Leptin: proinflammatory, leading to chronic inflammation. Patients with higher BMI levels and increased insulin resistance were found to have increased leptin levels.[Leptin is a good hormone at normal levels, but there is leptin resistance] Adiponectin: anti-inflammatory and antidiabetic effects. Higher adiponectin levels result in decreased hepatic gluconeogenesis, enhanced glucose absorption, and enhanced skeletal muscle and hepatic fatty acid oxidation. Levels drop as visceral fat increases. -Dr. López-Jaramillo, a Colombian endocrinologist and researcher, and colleagues published a review in 2014 examining the imbalance in the levels of leptin and adiponectin in individuals with metabolic syndrome. This imbalance (increase in leptin and decrease in adiponectin) is linked to obesity and insulin resistance, which has been shown to increase the risk of T2DM. It has been shown that IF has resulted in the reduction of leptin levels and increased levels of adiponectin, which leads to decreased insulin resistance and increased insulin sensitivity. -IF allows pancreatic beta-cells to rest by not having to secrete insulin constantly. This allows the beta-cells of the pancreas to improve in function over time. In addition, IF has been shown to lead to noticeable weight loss and loss in body fat, both of which play an important contribution in managing T2DM. Research demonstrates that this weight loss increases insulin sensitivity and decreases the need for insulin therapy, making IF a powerful approach for improving metabolic health. AMP-Activated Protein Kinase (AMPK) and Its Role in IF and T2DM Recent research has highlighted an important enzyme seen in IF, AMP-activated protein kinase (AMPK), which plays a vital role as an important energy sensor in cells. It is activated when cellular energy levels are low, such as during IF. A 2020 research study in Nature Reviews Endocrinology explains that activation of AMPK aids in suppressing gluconeogenesis and stimulates fatty acid oxidation, leading to optimal energy balance and reduction of visceral adipose tissue accumulation, a major contributor to insulin resistance and T2DM progression. AMPK is upregulated during fasting, which enhances glucose metabolism and reduces insulin resistance. This is imperative in managing T2DM, as it counters the effects of insulin resistance associated with T2DM.Exercise, which also promotes AMPK activation, complements IF and can promote a synergistic effect in improving insulin sensitivity and promoting fat burning, New Research Findings on IF and T2DM -The EARLY (Exploration of Treatment of Newly Diagnosed Overweight/Obese Type 2 Diabetes Mellitus) study is a randomized clinical trial published in JAMA Network Open (2024). Findings In this randomized clinical trial study found that a time-restricted eating window significantly improved fasting glucose levels and HbA1c levels in individuals with T2DM. The study examined the effect of a 16-week 5:2 meal replacement (5:2 MR) fasting plan that consisted of five days of normal eating and 2 days, nonconsecutive of restricted diet (500-600 calories). This group was examined alongside a group of patients who took metformin 0.5 g BID and empagliflozin 10 mg QD. The study wanted to investigate the changes in HbA1c in Chinese adults with early T2DM.-The study was a randomized clinical trial of 405 adults, and a study showed that the 5:2 MR approach led to better glycemic control at 16 weeks compared to the counter treatments with metformin and empagliflozin. The 5:2 MR group had the greatest reduction in HbA1c (-1.9%), followed by metformin (-1.6%), and empagliflozin (-1.5%). The 5:2 MR plan also revealed the greatest weight loss (-9.7 kg), followed by empagliflozin (-5.8 kg), and metformin (-5.5 kg). -This research suggests IF, such as 5:2 MR, can be a powerful tool in the management of T2DM and improving metabolic health. This study can potentially open doors for healthcare providers to provide the 5:2 MR approach for individuals as an effective initial lifestyle intervention. However, follow-up studies are needed to assess the effectiveness and durability of the 5:2 MR.Safety and Risks of IF in T2DM. -IF when combined with glucose-lowering medications (e.g., insulin, sulfonylureas, GLP-1 agonists) can increase the risk of hypoglycemia. Also, prolonged fasting can lead to nutrient deficiencies if not planned carefully. Patients should be counseled on maintaining a balanced, nutritious diet during non-fasting days. -IF is not suitable for everyone. Children under the age of 18 should not try IF due to needing proper calories for adequate development and proper growth. Also, it is recommended that pregnant or breastfeeding women do not undergo IF. It is advised that people with eating disorders should not try IF. -Individuals with certain medical conditions, such as kidney stones or gastroesophageal disease should speak with their doctor before trying IF. Also, patients on insulin or other glucose-lowering medications should adjust their dose and talk with their healthcare providers to prevent hypoglycemia during fasting. It is recommended that each person speak with their doctor to discuss the safety and risks of IF and see if it would benefit the individual before starting IF. -Many studies have explored the benefits of IF at the micro level revealing its cellular benefits and on a macro level of the body as a whole. However, more research is needed to confirm the long-term effects of IF on glycemic control and its sustainability as a therapeutic approach for T2DM. Conclusion:-IF shows potential for improving glycemic control, promoting weight loss, and enhancing metabolic health in individuals with T2DM. Despite its benefits, IF may present with risks, such as hypoglycemia, nutrition deficiencies, or dehydration in certain patients. Therefore, it may not be suitable for all individuals. It's important to monitor patients who engage in IF, especially for patients with T2DM. Patients should follow up with their doctor for individualized IF plans in patients with T2DM. ______________This week we thank Hector Arreaza and Cameron Carlisle. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Albosta, Michael, and Jesse Bakke. “Intermittent Fasting: Is There a Role in the Treatment of Diabetes? A Review of the Literature and Guide for Primary Care Physicians - Clinical Diabetes and Endocrinology.” BioMed Central, BioMed Central, 3 Feb. 2021, doi.org/10.1186/s40842-020-00116-1.Blumberg, Jack, et al. “Intermittent Fasting: Consider the Risks of Disordered Eating for Your Patient - Clinical Diabetes and Endocrinology.” BioMed Central, BioMed Central, 21 Oct. 2023, https://clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-023-00152-7.De Cabo, Rafael, and Mark P. Mattson. “Effects of intermittent fasting on health, aging, and disease.” New England Journal of Medicine, vol. 381, no. 26, 26 Dec. 2019, pp. 2541–2551, https://doi.org/10.1056/nejmra1905136.Guo, Lixin, et al. “A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes.” JAMA Network Open, vol. 7, no. 6, 21 June 2024, https://doi.org/10.1001/jamanetworkopen.2024.16786.Herz, Daniel, et al. “Efficacy of Fasting in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review.” Nutrients, U.S. National Library of Medicine, 10 Aug. 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10459496/. Herzig, S., & Shaw, R. J. (2018). AMPK: Guardian of metabolism and mitochondrial homeostasis. Nature Reviews Molecular Cell Biology, 19(2), 121-135.Longo, V. D., & Mattson, M. P. (2014). Fasting: Molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-192. https://doi.org/10.1016/j.cmet.2013.12.008López-Jaramillo P, Gómez-Arbeláez D, López-López J, et al. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes. Hormone Molecular Biology and Clinical Investigation. 2014;18(1):37–45.Mattson, Mark P., et al. “Impact of intermittent fasting on health and disease processes.” Ageing Research Reviews, vol. 39, Oct. 2017, pp. 46–58, https://doi.org/10.1016/j.arr.2016.10.005. Patikorn, Chanthawat, et al. “Intermittent fasting and obesity-related health outcomes.” JAMA Network Open, vol. 4, no. 12, 17 Dec. 2021, https://doi.org/10.1001/jamanetworkopen.2021.39558.Sharma, Suresh K, et al. “Effect of Intermittent Fasting on Glycaemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” TouchREVIEWS in Endocrinology, U.S. National Library of Medicine, May 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10258621/#:~:text=In%20IF%2C%20eating%20habits%20are,the%20risk%20of%20developing%20T2DM.Xiaoyu, Wen, et al. “The effects of different intermittent fasting regimens in people with type 2 diabetes: A network meta-analysis.” Frontiers in Nutrition, vol. 11, 25 Jan. 2024, https://doi.org/10.3389/fnut.2024.1325894. Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

We had author Joel Greene on the podcast early in 2024, but we enjoyed that conversation so much we invited him back--this time in the studio (all the way from California!). This is the first of two conversations we had with Joel about God, health...and how to thrive!Joel is the creator of the VEEP Nutrition System… He is a featured author, speaker, and guest in top tier publications and his system has been featured on the Dr. Phil Show (among other shows), where it has delivered astounding life-changing results.He is the author of books such as The Immunity Code and his new book, “The Way: The Immunity Code Diet.”Visit his site at www.veepnutrition.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science for a fascinating exploration of what your fat is truly telling you. Delve into the role of hormones like leptin and adiponectin and their amazing influences on metabolism, appetite, and even fertility. Dr. Cooper explains why chronic dieting can make it harder to lose weight and how environmental toxins can disrupt hormone production. Discover the differences between brown and white fat, and why aiming for a specific body fat percentage should be done with caution and professional advice. Key Takeaways: -Hormones like leptin play a crucial role in communicating the body's energy status to the brain. -Chronic dieting can suppress leptin levels, leading to slowed metabolism and increased hunger. -Adiponectin has anti-inflammatory effects and helps regulate blood sugar and insulin sensitivity. - Environmental toxins like BPA can adversely affect hormone production and increase health risks. -Focus on balanced lifestyle choices rather than trendy supplements to maintain healthy hormone levels. Resources from the episode: Learn more about Fat Science here.  Connect with Dr. Emily Cooper on LinkedIn.  Connect with Andrea Taylor on LinkedIn.  Connect with Mark Wright on LinkedIn.  Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice. If you have a show idea, feedback, or just want to connect, email Mark Wright at mark@beatsworking.show.

Welcome to the latest episode of The Hormone Prescription Podcast, where empowerment at midlife isn't just a dream—it's your reality! In this enriching episode, we're thrilled to bring you insights from the esteemed Dr. William Li. Dr. Li isn't just any guest; he's a life-changing force in the world of medicine. From the prestigious stages of TED Talks to the informative panels of top news programs, Dr. Li has become the voice that's reshaping our understanding of health. His revolutionary insights have contributed to more than 40 medical treatments for diseases making waves in the waters of wellness. But that's just the tip of the iceberg... In today's discussion titled Eat to Beat Disease: The New Science of How Your Body Can Heal Itself, Dr. Li picks apart the essence of his New York Times bestseller which dives deep into the healing powers of food. This isn't a conversation about fad diets; it's a masterclass in how everyday nutrition can be your most powerful medication. Imagine navigating midlife with a treasure map that leads to vitality and longevity. Thanks to Dr. Li, you won't have to imagine much longer as he reveals the inner workings of how the food you eat can help you combat illness, not just survive, but thrive. For all you seekers of wellness and warriors of well-being, this episode is a beacon of hope, guiding you towards a life where diet isn't just about your waistline, but about staying one step ahead of disease. It's time to get inspired and learn how to: Burn fat without starving yourself Heal your metabolism for good Use food scientifically proven to fuel longevity Dr. Li's message is tailored not just for the health-conscious but for anyone who's yearning for control over their body's destiny. And for midlife women, this might just be the Hormone Prescription you've been waiting for. Prepare yourself for a conversation that's loaded with practical advice, backed by rigorous science, and imbued with a dash of culinary magic. Are you ready to transform your midlife experience? Then grab a comfy spot, tune in, and get ready to Eat to Beat Disease! --- Featured in This Episode: Why your kitchen holds the key to disease prevention Dr. Li's groundbreaking research that's revolutionizing the medical community Strategies to nourish your body at the cellular level for lasting health A peek into Dr. Li's latest literary masterpiece   Dr. Kyrin Dunston (00:00): Natural forces within us are the true healers of disease. Hippocrates, stay tuned and find out your most powerful tool when it comes to mastering your metabolism at midlife with Dr. William Li. Dr. Kyrin Dunston (00:15): So the big question is, how do women over 40 like us, keep weight off, have great energy, balance our hormones and our moods, feel sexy and confident, and master midlife? If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself Again. As an OB GYN, I had to discover for myself the truth about what creates a rock solid metabolism, lasting weight loss, and supercharged energy after 40, in order to lose a hundred pounds and fix my fatigue, now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results and to give you clarity on the answers to your midlife metabolism challenges. Join me for tangible, natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston. Welcome to the Hormone Prescription Podcast. Dr. Kyrin Dunston (01:08): Hi everybody. Welcome back to another episode of The Hormone Prescription with Dr. Kyrin. Thank you so much for joining me as we dive in with Dr. William Li to talk about eating to Beat disease. Eat to Beat Disease is the name of his New York Times bestselling book on the new Science of How Your Body Can Heal Itself. He also has another book, Eat to Beat Your Diet, burn fat, heal your Metabolism, and live longer. Needless to say, he is an expert when it comes to what to eat, how to eat when it comes to improving your health, and he is super passionate about food. He loves to cook like I do. So we had a really great conversation I think you're going to enjoy. He is gonna talk a little bit about the quote from Hippocrates that I shared with you in the teaser, and also another one from Bruce Li and another one about what discovery actually consists of and how it can help you when it comes to creating great health. Dr. Kyrin Dunston (02:14): I'll tell you a little bit about Dr. Li and then we'll get started. Dr. William Li is a medical doctor and internationally renowned physician scientists and author of the New York Times bestseller Eat to Beat Disease. His groundbreaking research has led to the development of more than 40 new medical treatments that impact care for more than 70 diseases, including diabetes, blindness, heart disease, and obesity. His TED Talk, can we eat to starve? Cancer has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, C-N-N-C-N-B-C, Rachel Ray, and live with Kelly and Ryan. He's been featured in USA Today Time Magazine, the Atlantic O Magazine and more. He is president and medical director of the Angiogenesis Foundation and he's leading global initiatives on food as medicine. And he has a new book, New York Times bestseller, Eat to Beat Your Diet about burning fat, healing your Metabolism of living longer. And it was released in March of 2023. This is a super fan girl moment for me because Dr. William Li is amazing, personable, and passionate. I think you're gonna love him as much as I do. Please help me welcome Dr. William Li to the show. Dr. William Li (03:29): Well, thank you very much Dr. Dun, it's a real pleasure. Yes, it's Dr. Kyrin Dunston (03:32): A pleasure to have you here. I heard you speak at a conference a few years ago and I thought to myself, oh, I wanna have him on the podcast. That would be amazing. And you're very in demand. So I think it took me this long to be able to get you on the show, but I'm super honored to have you here. Your books have transformed so many people's lives and really helped to move forward people's level of understanding about their diet, what they're putting in their mouths and their health, the outcomes they're getting. So I'm very curious, as a traditionally trained physician trained, how did you come to become so passionate and knowledgeable about eating to beat disease? Dr. William Li (04:21): Well, you know, those of us who trained in traditional medicine know how little nutrition actually is taught in medical school or during training, and that's certainly true in my own education. I had some secret sauce that I brought into the equation before I went to med school. I studied biochemistry in college and afterwards I took a gap year. And during my gap year before going to medical school, I traveled to the Mediterranean. I lived in Italy and I lived in Greece. And my interest all the way back then was in studying the interconnections between diet, culture and health. And what really interested me, and this is again, long before I went to med school, I was curious about how these cultures in Italy and Greece developed their food traditions and the seasonal eating that they did using whole plant-based foods, primarily long before these terms became popular and how much it meant to them culturally. Dr. William Li (05:26): In other words, people are eating, the children are eating what the parents are eating, who cooked what the Nonas or the grandmas are eating. And they passed these traditions and recipes down and it's been going on for hundreds of years. And, and that was really interesting to me because of my own background being Asian American. I grew up with cultural legacies that came from my own family and we saw lots of things mixing together, but I was always very curious about that link. And of course, being in the Mediterranean, I got to see people viewing food not outta fear, which is what we so often encounter. Oh, I don't know what I should eat. Should I be afraid of saturated fat? Should I be fearing dairy? Should I be fearing soy? I saw something completely different. And what I saw was people approaching food with joy. Dr. William Li (06:16): When people in the Mediterranean sat down for a meal, they usually sat down with company. And when they were, and the conversation they had inevitably when they were eating together was about the food that was placed in front of them and its tastes and the seasonality and how their mothers prepared or how their spouses would prepare the foods at home. And it made me realize as I then, you know, later went to medical school by contrast, how absent the idea of food and health in our culture and American culture was, and so I could never forget that. And as I memorized bugs and drugs, as you know, from medical training, my, you know, my, and as I observed all the terrible, crappy food and lifestyle, the diet, lifestyle of the medical student and the resident was just so terrible. I started to realize that there clearly was a missing piece of what modern doctors are trained on. Dr. William Li (07:17): And I think that the tide is changing a little bit, but here, hear me out for a second. What was missing was really the toolbox of the medical community. Before 1930, we had no antibiotics, we had no fancy drugs. You know, doctors going back in the beginning of the 19 hundreds and going back thousands of years really only had what was in the natural world and food and lifestyle as our only tools. And somehow in those last, you know, let's say 90 years, a hundred years or so, we lost sight of the fact that food is a tool in our toolbox. And so we have, we're training doctors to practice with inventions, medications surgery and radiation and all this other kind of stuff. And we've forgotten our roots and the roots of the food being a tool in the toolbox is so important because we now have the science. Dr. William Li (08:13): And I'm a scientist, I'm an internal medicine doctor trained for, for, you know, young and old men and women, healthy and sick. And I realized the huge wonderful opportunity was for people who had the scientific knowledge like me to dive, to do the deep dive, kind of like the, I could dive into the mosh pit of food using the same scientific rigor that we use for drug development to try to understand why foods are good for us, we know they taste good, now we have a better understanding of why they're actually beneficial as well. So I'm all about what foods to add and the new knowledge coming out of that rather than what foods to avoid. Although obviously there are some foods that one should avoid as well. Yes, Dr. Kyrin Dunston (08:55): Thank you so much for sharing that. You know, as you were speaking, a couple things came to mind. I recently watched a British series that I think took place in the 1800s. And whenever somebody felt ill, they gave them bone broth. They didn't call it bone broth, but they called it broth. Yeah. And so exactly what you're saying is something that I've observed and, you know, chicken soup, where does that come from? It's broth. Well, it's bone broth and then what you shared about traveling to Italy. And I have the pleasure of traveling to France with Walter Willette from Harvard. I think he's the author of, is it The French Dr. William Li (09:34): Paradigm? Yeah, I know Walter. Yes. Very good. Dr. Kyrin Dunston (09:36): Yeah. And to study why they don't have the, the cardiac and other diseases that we have based on their diet. And so that was really fascinating. So you just said that picking your food from a joyful place versus a fearful place, which I love. And really focusing on what foods to add. So what has been most surprising to you in the research that you've done in terms of what foods to add? Dr. William Li (10:05): Okay, so the wonderful thing about being a scientist is that we're always surprised because we're at, you know, as a scientist, most people think that researchers, scientists spend all their time getting together and dishing brainiac rocket science on each other. But in fact, that's not what real scientists do. When we get together with other scientists, we spend all of our time talking about questions that we don't know the answers to. And so we don't actually talk about what we know. We talk about what we don't know. And so for me, the opportunity to do research on food as medicine is a wonderful opportunity to continuously being surprised by what we're actually discovering. Give you some examples. All right. We know that berries are healthy, right? I mean, colorful berries eat the rainbow. I love strawberries, I love blueberries, I love blackberries. They're, they're good for us. Dr. William Li (10:58): They're anti-inflammatory. I think most people would actually know that. Okay, well, when I first dove into this food as medicine world, one of the things that I did with colleagues at the National US National Cancer Institute, this, my colleagues were actually doing drug discovery, trying to find new cancer drugs. And so in that process you have, as a researcher, you're not aware of what you're testing. So they call it blinded or masked. So you have no idea what you're testing to be objective. And you would throw these chemical powders or liquids into a test system to see if they would starve cancer by cutting off the blood supply. All right? That's what this project was all about. And what I did in a, what was considered daring back then, I decided to sneak about 20 different food extracts into the system. So maybe there were 50 drugs to test, and I snuck 20 extras. Dr. William Li (11:51): So there were 70 site things to test, and literally we were testing food versus drugs head to head in the same system for cancer discovery and drug development. Okay? Cancer drug treatment. I was so surprised to discover that strawberry extracts contain something called ACH acid. So you don't have to be a chemist, a chemist, but just know that people that are doing the research, we're beginning to figure out what these substances are. Allergic acid is a powerful anti-cancer substance because it cuts off the blood supply that's actually growing that could feed a cancer cell. And we validated and tested this head-to-head with cancer drugs. Okay? Now that was a big surprise. Fast forward to just a couple of weeks ago, I was surprised yet again that other researchers have been studying strawberries looking at the same types of substances, the IC acid. And now we know there's another group of compounds called pro anthocyanins. Dr. William Li (12:49): And guess what they've been shown to do in clinical studies. This is a study from the University of Cincinnati where they looked at about 30 men and 30 people with mild cognitive deficits. So not full on dementia, but heading in that direction. And they found that one cup worth of strawberries per day over the course of six weeks could improve memory and cognitive performance. Amazing. Now, and that's the same substance. So here it is, you know, strawberries have activity in the Cancer Drug Act along the lines of a cancer drug. Strawberries have activities and a clinical study along the lines of helping people who are having cognitive difficulties. If that's not foodist medicine, if that's not real research being conducted, I don't know what is. And these are the kinds of surprises that I literally get out of bed, right? Roll out of bed, and I've got like one foot in the past, you know, the same stuff that you and I trained on Dr. Dr. William Li (13:49): Dunson, you know, the bugs and drugs as I call them. Okay? Right. And, and, and the other foot in the future, because this is what we're discovering how the mother nature's pharmacy, pharmacy with the f not a pH, the mother's nature's pharmacy, is more incredible than we ever imagined. And so this is why I think I'm surprised by tea. Green tea is good for you, but so is a super fermented tea called P or tea. Guess what? P or tea is even a probiotic tea that improves metabolism studied in human trials. Amazing. And so every day I am surprised by something and it makes me smile. And it makes me happy to realize that we are able to lean into the foods that we should be adding to our system and learning more about that and not just vilifying foods, which has been really kind of like the cave we've crawled outta. Dr. Kyrin Dunston (14:44): Yes. You know, you mentioned poo or tea and I call it dirt tea because it has a different taste, so you have to get used to it. But because of the health benefits, I remember when I first tried it, I didn't care for it, but I said, I'm gonna learn to like it because it's good for me. And now I love it. So I think that what are a lot of people's objections to eating in ways that are healthy? You know, I don't know anybody listening when's the last time they ate a fresh strawberry or a fresh green green or had something like a poo or tea. But people say it's expensive. They say it's time consuming. It's not convenient. They say it doesn't taste good. So how do you, you've done this beautiful research and really shown that these foods can help and bring them into your diet. These other foods maybe you wanna eat less of, but the practicalities of those cost in terms of time, financial expense, and then also the dislike. How do you help people get past those? Dr. William Li (15:55): Sure. Okay. So I wrote two books that became New York Times Best Sellers. Yeah. Eat to Beat Disease and Eat to Beat Your Diet. And one of the things that I did as I wrote each book is I created tables and charts of foods that have been scientifically and clinically shown to be beneficial to help boost your body's health defenses. These foods make you healthier, okay? And the evidence and the science proves it. Okay? So, but I took all the, I did all the heavy lifting for my readers. And so the tables and charts are there. What I tell people to do is if you take, if you crap go of my books and you just take a photograph, screenshot of the tables and charts, and please take a sharpie or pencil or, or whatever you're writing with highlighter and circle the foods among those 300 that you already like, you know, maybe some people don't like green beans or Brussels sprouts, but maybe they like peaches or maybe like berries. Dr. William Li (16:51): You know, if you start circling these things, I always say I have not found anybody over the last four years. I've been challenged that couldn't find something, some foods, in some cases, many foods, but they're circling like crazy. And I said, guess what? You have just won the lottery, the food and health lottery because you've circled the foods that are already good for you and you like them. You've said that you like them. So if you start eating healthy foods that you already like, you are way ahead of the game. 'cause You're, you already like the foods that are good for you, start with that. Go to the grocery store. And, and so that's one way of actually addressing the like versus dislike. I'm starting with you and I'm trying to find out in a very personal way, what are your taste preferences? Everyone's different. Everyone's got their comfort foods. Dr. William Li (17:35): Everyone, you know, everyone can remember something that mom cooked when we were kids that we actually really resonate with. That's cool because you're almost certainly going to find something good, and you're gonna find something that's healthy. Now, that's one thing. What about the cost? Look, there was once this idea that you have to eat organic and you have to eat local and you have to eat fancy stuff. Turns out that the research is showing that the dirt cheap stuff, not just dirt tea, but dirt cheap foods is actually good for you. Yeah. Nuts and seeds, you know, walnuts, pecans, almonds, all those kinds of things you can buy in bulk. You know, go to one of those big discount stores and buy them in bulk. Great for our gut health, which then improves our metabolism, helps our fat hormones, helps all kinds of other aspects in our lives. Lowers cholesterol. It doesn't have to be expensive. Dr. William Li (18:26): One of the least expensive things I can think of that I actually like and I, and I put into my own shopping cart is not fancy pants at all. I love navy beans. All right, Navy beans. You go to the middle aisle and you just get a can of this stuff. They're pretty inexpensive. Navy beans have lignins, they've got great soluble fiber. They eat super fast, super cheap, crack a pan, the crack thing over there, rinse 'em out. Okay? I rinse all that cloudy stuff away from it. All right? Stick 'em in a pot. Heat 'em up, throw some inexpensive herbs that you can get outta your pantry to light it up a little bit. And you got yourself a gut healthy meal that's good for your gut microbiome, shown by evidence that it's not only inexpensive, it actually works to improve your metabolic health. Dr. William Li (19:16): So I think that, you know, if you take a look at healthy food, it's not only for the 1%. I think in fact the elemental foods, the things that used to be widely available to everyone are, can actually be really, really healthy, including dried foods, which tend to be healthy. You can store them longer, you can buy them in bulk. And that's totally fun. Here's something a lot of people don't realize. I know that it's true that eating mostly vegetarian, all vegetarian, you don't have to be vegan, but a mostly vegetarian diet is gonna be healthier for you. But if you eat seafood, okay, you don't have to go to the fancy fish market to buy expensive line cuts, whatever. Okay? If you go to the middle of the grocery store and you just carefully look for little tins of fish, I'm not talking about cat food. Dr. William Li (20:06): Don't go, don't go to the pet food section , okay? I used to think canned tuna was cat food because it smelled exactly like what we'd feed a cat. But there is a, in the Mediterranean, there's a long history of tinned foods, tinned sardines, tinned mackerel, tin tuna. They put a little extra virgin olive oil and they added some spices and herbs. They might put some like piquillo peppers or something in, you can find these in a grocery store and they're not expensive. You can buy a big pack of them, you can put 'em in a pantry. And man, do they make a tasty Omega-3 healthy oil final. Not only the Omega-3 fats, but also olive oil when they're cooked with that, you can just put that with a piece of crusty sourdough bread and have some raw carrots and you put yourself a real snack. Dr. William Li (20:53): And you know, wherever the girls, the girls dinner or the girls meal, like they talk about something like that, can be inexpensive and incredibly tasty and healthy for you as well. So I always tell people, don't let price be the obstacle. There's lots of things that are inexpensive that anyone can actually afford. Okay? And then the other issue about convenience, all right? I think that if you look on the internet today, you pick an ingredient, beans, kale, tomatoes, what have you, nuts, tree nuts. And if you want to actually find something, a simple way to do it, you don't need to bust open that old yellowed thick book that your mom used to keep around as a cookbook, right? passed around for generation, you, you know what I'm talking about, right? Yeah. All you gotta do is to go on a Google type ingredient, you know, collars or kale and type a recipe and type simple, how about 15 minutes, alright? Dr. William Li (21:48): 20 minutes and hit search and type, click on the video and watch somebody show you how to do it. All right? It's easy to do. And so I think that we should, and by the way, there, I, I have to tell you, as somebody who enjoys cooking, I'm not only a scientist and a doctor, I actually love cooking. But to me it's joyful. It's relaxing. I get some time by myself, I'm creating something. Listen, if that actually fits your personality as well, there's nothing better than knowing that you're eating and feeding your loved ones, then your friends and family as something that you put together. And you know everything that you put into it, and you can make those decisions for other people and it tastes great. So again, I hear you point out the exact same things that lots of people talk about as obstacles to healthy eating. And from my perspective, they're not really obstacles at all. You just have to look at them in a different way. Dr. Kyrin Dunston (22:41): I love that answer and I wholeheartedly agree. I was blessed to be raised by a mother who actually was a trained chef. She trained with Anne-Marie Colman at the Natural Gourmet Cookery School in New York. And Anne-Marie was one of the pioneers in teaching people how to cook mostly. I don't think she dealt with meat at all, actually. It was vegetarian, healthy, tasty meals. So I learned at a young age how to cook healthy food. Of course, I went off to medical school and I came back and told my mother, ' we heal with steel mother . 'cause I thought I knew better. It wasn't until I had my own health challenges that I went back to her and then really started to pay attention to how she cook healthy food that is delicious with healthy ingredients and, and really learns how to do it in an efficient, cost effective manner. Yeah. So I think it's something, it's a skill that anyone can learn. And abso you described beautifully. Dr. William Li (23:42): Absolutely. And you know, listen, if you know how to change a tire in your car or put in or change your oil in your engine, if you know how to fix the gutter or the, or, or the, the drain sink, if you know how to plunge a toilet, you can actually, you're, you're smart enough to know how to actually cook something tasty. And I like them. I I love the idea. I don't know, I, I don't know if you're saying healing with steel, it refers to cookware, but like, you know, but oh, . But, that's another way to think about it. You know, like, look, you don't have to go to the hospital and sit in the waiting room, you know, to be called by the nurse. I think that there are, look, I'm, I, we're both doctors and so I'm quite confident that we're on the same page. Dr. William Li (24:26): There are medical issues that you must go to your doctor for and communicate with your doctor for, and that only your doctor can really solve for you because it's not something you can really tackle at home. But on the other hand, healthcare, and I think you'll agree with me as well, it doesn't happen in the doctor's office or the hospital. Healthcare is what we, what people deliver for themselves between visits to the doctor's office, between visits to the ER, to the hospital or the infusion clinic or wherever you're going. You care for yourself. We do medical interventions, you know, in a doctor's office, we can do assessments, but the care for your health is what we do for, to all of ourselves at home. And, and food is just, you know, one of the several important things, because obviously we can't just think about this over simply. Dr. William Li (25:14): I mean, you've got exercise, you've got stress management, you've got sLip socialization, all things that are part of self-care. And, and look, everybody out there is in the world now, you know, in this new era of self-care, right? Where we know not to overwork ourselves, we know not to overload ourselves at work. Self-Care is really sort of a new era where we are taking responsibility for the amount of stress that that either we put in ourselves or other people, people put in ourselves. I think nutrition and eating well, and importantly, eating the things that you like that are healthy, all right? It's gotta taste good. That's how our, and it's just another thing to really think about and cultivate for yourself. Dr. Kyrin Dunston (25:59): Yes, I am saying that 2024 is the new self-love and self-care. It's like the next level. It's time to bump it up a notch and really make self-love an action word. It's a verb. And really meeting your needs and your wants and your desires to a high level, including your diet. I do know that a lot of women listening are dealing with what I call midlife metabolic mayhem. The 60 plus symptoms that women start experiencing over 40, the top two being fatigue and weight gain. So they're gonna wanna hear something from you about your second book, eat to beat your diet, how you heal your metabolism, burn fat, and live longer. So can you talk a little bit about the challenges for all of us, but maybe particularly for women over 40 with their metabolism and what's happening there and how they can work with their diet to assist them? Dr. William Li (26:58): Yeah, well listen you know, if you're a woman in your, in a, in the middle of your life and you're struggling with the actual issues or the questions about weight gain, weight management, fatigue, you know, all the things that, well, I think most people recognize, dread and maybe even accept that they're gonna have to contend with as they get into their forties and fifties and, and later in their lives. I have some good news. First of all, my book, Eat to Beat Your Diet, is not a diet book. That's a trick title. It's an anti-D diet book. I wrote a book about how you don't need to go on these intense, crazy diets that might actually help you lose a few pounds or maybe even more than a few pounds, but you can't stick to them. But how you can instead use the latest thinking about human metabolism, about body fat and the connections to our hormones or to our energy levels, to our ability to live rich, fulfilling lives in a way that we didn't recognize before. Dr. William Li (28:01): And let me explain this in a way that I think people can understand. All of us probably do something pretty similar, right? You get up in the morning, roll out of bed, take a shower, come out of the shower, and you're drying off and you probably got a mirror in the bathroom and out of the corner of your eye, you probably see on your naked body a lump or a bump that you are not happy with. It doesn't matter if you're a big person or a small body person. We all see this stuff, right? And then what's the thing you do? You go cur you curse. Like, ugh, I don't wanna see that. Then the next thing you do is what? Step on the bathroom scale. And that number that comes up isn't the one that you are hoping for you to curse again, all right? Dr. William Li (28:38): First thing in the morning, you've cursed yourself twice, right? And if this sounds like a familiar story, and I'm exaggerating a little bit, but I think most people resonate with it. 'cause I do the same thing. I used to do the same thing. We kind of associate our weight with our health. We associate body fat with something very negative. And we always talk about negativity and body fat. Look, we're, so, it's maybe part of our human nature. I don't care if you're a vegan or not, but if you actually go to a grocery store and you're wheeling, you're pushing your cart around and you're gonna be pushing it by the meat section, a butcher section, and you see that gigantic t-bone steak that's got like a thick rind of white fat around it. I don't care if you're like a, if you're, if you're like the, the biggest meat eater in town, everyone goes, Ugh, I hope nobody eats that. Dr. William Li (29:25): Right? So we're conditioned to think about body fat and the word fat in very negative ways. But what I wanna tell people in their middle age is that we don't always think about it, we don't always think about fat negatively. There's one situation I can tell you, everyone sees fat and smiles and you know what that circumstance is? That's when we see a baby or we see a pudgy baby. Mm-Hmm, you know, newborn, 1-year-old, big fat cheeks, double chin, rollie, polly tummy, , you know, big fat arms and legs. You're smiling right now, right? I'm, I'm not smiling saying it, right? We, that's one situation in which fat makes us feel happy. So think about what that means. Somewhere in our brain, we recognize that body fat is actually a good thing. In fact, if you saw a baby that was long and thin, like a fashion model, like a runway model with thin thighs and thin arms, like, like sharp chiseled cheekbones, , you'd be freaked out. Dr. William Li (30:22): You'd be freaked out, right? You go, you would, you would, you would run the other way. You would say, there is something seriously wrong with that baby, and you'd be completely right. Okay? So to understand body fat and metabolism and hormones in middle age, it's really helpful to do, to go, go way back and realize what body fat does for us when we're younger. Now, a lot of people don't know this, but our body fat and our hormones are really tightly interconnected. And our body fat and our health meaning good health, beneficial health, are tight, tightly, tightly tied together. All right? Now I gotta explain this. Most people don't know this, but if you go back, Dr. Duston back to med school, you remember we were sitting in embryology class and they were teaching us about how humans from dad sperm meets, meets mom egg, mom's egg and AEB of cells. Dr. William Li (31:13): And we had to memorize all the things that actually happened. Well, when the organs form, all right, one of the first organs that form are blood vessels. And that makes sense because every organ's gonna need blood flow to remain alive. The next tissue that really forms are nerves. 'cause That's the electrical system of the house of your body. And we all need electrical wires to power up our organs. All right? A third tissue organ that forms is body fat. Body fat is one of the early first organs that form. And by the way, at this point in our lives, we don't have waste lines. We don't actually have chins yet. We're still kind of forming our overall shape as humans. And you know where the body fat forms is as a ring around blood vessels. So when body fat starts forming, it forms as a cushion around our blood vessels. Dr. William Li (32:07): And you go, why would that be? Why is body fat forming on blood vessels? Well, it turns out, and we now know this, that our body fat, which is sometimes called adipocytes, adipocytes, adipose tissue, so we know, call fat tissue, these adipocytes the cells of fat around are living around blood vessels because each of these fat cells, adipocytes, are actually fuel tanks for the energy that we need to run our body. And where does the fuel get loaded? Into the fuel tank from our blood vessels? Because the food that we eat goes into the fuel, goes into the blood vessel, and the blood vessel loads them into the storage tank, which is our fat cells. And that's why fat starts forming around the blood vessel. So all around our blood vessels, all throughout our body, there's fat that actually starts forming. Now obviously the fat forms elsewhere as well, but it shows you just how important body fat is. Dr. William Li (32:58): Now, later in life, as we develop as teenagers, I mean, look, little boys and girls, five year olds, seven year olds, pretty much they look all the same, right? They're, they, they have the same body type, but later during adolescence, puberty, hips form, breast form, chests form, you know, facial features start reforming as well. That's where the future adult us begins. We start to look like the future adult who we're gonna be. And our body composition changes and fat starts moving in different places to where it needs to go. And we've got three kinds of fat that form, all right? And I'm telling you this because people who are middle age need to understand fat didn't form because you had too much to eat over Thanksgiving dinner, okay? Or that you went to that restaurant and you had, you know, you had too much on your plate. Dr. William Li (33:43): This is actually fat that is healthy fat. I'm talking about three types of fat that form, even when we're young teenagers and into young adults, you know, kind of the best shape of our lives. We've got subcutaneous fat that's under the skin sub under cutaneous skin fat. That's kinda like a wetsuit that protects us, that's healthy, helps to shape us. Then you've got visceral fat, which is gut fat, visceral meaning gut packed inside the tube of our body. So if you think about it, you could have a thin tube or you could have a big tube. People with large bodies have big tubes, but even people who are thin, who are thin, have thin tubes. And when, and the visceral fat can, it grows inside the middle of the tube of the body, you can't see in the mirror. All right? Dr. William Li (34:28): It's not the muffin top, it's not the double chin. It doesn't wobble under your arm. It's deep inside your gut. All right? And you need some of that. And then there's brown fat. And this is something that I think is really interesting is that brown fat, which we used to only think was in animals and babies, is a thin layer of fat. We're not talking about wiggly jiggly wobbly fat. That's not under your arms. Brown fat is quite different. It's paper thin, wafer thin, and it's pressed not close to the skin, but close to the bone deep in our tissues. We got some of it behind our breast bone. We got some of it around our neck. We got some of it a little bit in our belly, some of it behind between our shoulder blades. Brown fat is like an engine, like the stove top in your kitchen that uses gas. Dr. William Li (35:16): You want to blow some water. What do you do? You turn the crank, it goes click, click, click, click whoosh, you get the flame going on. That's what brown fat does. Brown fat metabolically whooshes fires up to create heat, right? For our body, and it draws that energy from our white fat, starting with a visceral fat, which so that you, so we, our fat controls fat. Now what happens? And there's all kinds of hormones that a fat is normally producing. This fat, healthy fat produces at least 15 different kinds of hormones. Adiponectin is one, is one that even helps our body absorb insulin and, and helps us release insulin and draw in our glucose so we have energy. So I'm bringing this up because people complain about not having enough energy. All adiponectin gives us our energy because it takes the food that we're eating and stores that energy into our fat cells. Dr. William Li (36:09): All right? And then we burn off that fat cell when we move around, and that's what gives us energy in our brain, in our muscles, everything. Okay? Now what happens is that if you actually overload the body's fat stores, if you overeat, you put too much fuel in your body, your body, like unlike a car where if you put too much fuel and it just splashes right out of the fuel tank, what does it do? Run down the side of your car, around the tires, and pool around your shoes. Now you're standing in a dangerous, toxic, flammable mess, right? In a gas station in your body, if we actually overload fuel, okay? By overeating, we just make more fuel tanks, those fuel tanks being fat cells. And so we, the more we eat, the more fuel we store, the more fuel we store, the more fuel tanks we need, the more body fat we need to make. Dr. William Li (36:54): And that's really why over consumption of food, good or bad actually will lead to more body fat being created. And the body fat that gets created, you can see it in the mirror, okay? Those are the lumpy, bumpy things, or they can actually grow in the center of your body around visceral fat. This is the fat that wraps around all your organs, because when you overeat and you have too much fuel and you've got too much fat wrapped on your organs, that fat becomes starved of oxygen. It becomes inflamed. It's like a forest fire that gets ignited inside your belly, you can't even see it. It's steep inside. And that inflammation rushes out throughout your body. And what it, one thing it does is it inflames fat upsets the, it derails the hormones like the fat hormones, like adipokines adiponectin. When that hormone gets derailed, you can't use it, you can't absorb your fuel. Dr. William Li (37:48): Well, and guess what? Now even though you have, you're loaded with a lot of fuel, you're not using a lot of fuel, you are tired, you're fatigued. So gaining too much weight leads to fatigue, inflammation accompanies it. All right? So overeating is one of these things that we need to really be careful about. Now, the other thing that happens in middle age, people go, oh, my metabolism's gonna slow down. There's something I can do about it. It's my fate, right? And indeed, people's bodies change. Women and men, but especially women, I think they notice it a lot more when your body shape changes, when you hit your mid forties and into your fifties you know, I don't know what I can do and I'm looking just like my mom did. All right? So the fact of the matter, it used to say, I've gained too much weight because my metabolism has slowed down. Dr. William Li (38:31): Nothing I can do about it. Right? Wrong. We used to think slow metabolism causes excess body fat, but in fact, it's the other way around. Too much body fat slows down your metabolism. And we know this from a seminal research study that was conducted just in 2021, published in the Journal of Science, one of the most credible journals in the world, where they found that all humans only undergo four phases of metabolism in their life and in the middle phase of metabolism. All right? So when you're born, everyone's born with the same metabolism. One year old, it shoots straight up from one 8-year-old to 20 years old. Your metabolism comes down to adult level. And then from 20 to 60, this is exactly where middle age occurs. 40, 45, 50, 55. Human metabolism is designed to be rock stable. It is not hardwired to go down. We are not programmed from birth to have a slow metabolism. Dr. William Li (39:28): We hit our middle age. And so anybody listening to this, you gotta realize everything that we thought has just been the story has been changed because we now realize that we are, our bodies are hardwired. It's our birthright to have a normal stable metabolism in middle age only at age 60, 60 to 90 slows down a little bit, okay? But not huge. It slows down a little bit. Now, what happens is that if you gain extra body fat, if you have extra fuel consumed, all right, and you're not moving, and that extra fat causes the inflammation disrupts the hormones, the fat hormones we're talking about here, you know, dip, pectin, ghrelin, I mean, these are all kinds of lectin. These are all hormones that are affected by, that are needed and healthy for us when we have the right amount of body fat and energy. Dr. William Li (40:14): But when we have too much of it, not only does that slow down our metabolism, but the excess inflammatory fat derails our hormones. When you derail these hormones, it's literally taking a train, okay? And just chucking it off the rails. Now it all, all heck breaks loose. And now you don't know if you're hungry or not hungry. Well, maybe I'll just eat some more. No, you know, you're eating more food now, you're eating more fuel. It's making everything worse. And then it, and the excess body fat slows down your metabolism. So the explanation for people who are middle reaching, middle age to say, I'm fatigued. I'm gaining weight. I don't know what to do, I don't think I have a choice. One of the things that modern research is showing us is that number one, you can actually try to restore your body's metabolic setpoint. Dr. William Li (41:01): It might take time to do it, but one thing to do is actually to burn down excess body fat. And to do that, you want to eat less e even intermittently fast and be a good way of doing it. Second, you wanna eat good quality food. 'cause You don't wanna be eating food that's just gonna blow up that inflammatory fat. You wanna eat good quality food, less of it, stay away from the ultra processed stuff, the added sugars, the added, you know, carbs. Then what you wanna do is exercise. You wanna stay physically active. You know, a body in motion stays in motion as the old law of thermodynamics or physics. And so you wanna actually stay in motion walking exercising. You don't need a trainer. You just need to stay active. You're gonna be burning down some of that extra fuel. You need good quality sLip because our metabolism burns down extra fuel when we're in REM sLip. Good quality sLip. All right? Now, why, by the way, why is all this not happening to us? Why is it so difficult to do this when we are in our mid forties, for women watching this? Think about it, how complicated our lives are at middle age when you are 20. You know, you might be struggling with various things, ideas, but you might have seen something like a mountain, but really a mold hill compared to what you're dealing with in your 40 bucks, all right? Yes. Dr. Kyrin Dunston (42:15): Right? Dr. William Li (42:16): Okay. So back then you were working out, you were looking good, you were fitting into whatever clothes you wanted, and you had plenty of energy and you know, you could do whatever you wanted and you didn't seem to gain weight, but you're active, all right? Now, fast forward the decades, and now you're in your mid forties. We got so much going on, all right? And I'm just trying to talk to people like, you know, who are listening, like, like real people, right? I mean, look, you got your spouse to worry about. You got stressors with your family life. You got your kids to worry about, you got your mortgage, you got your job to worry about, your boss worried. You get your car payments. And then, oh, by the way, if you follow anything in the news, we're worried about the election, worried about the war, worried about, you know, what kind of sickness is going on. Dr. William Li (42:58): Look, there's a lot of stressors going on, okay? And those stressors make it really hard for us to focus on making good decisions about the food. We choose quality food. Those distractions make it very difficult to eat smaller quantities, smaller portions. In fact, they're so distressed, so stressed out, we eat a lot. Those distractions make it hard to exercise and stay active. Those stresses prevent us from getting good quality sLip, which interferes with metabolism. So it's not that our fate is hardwired in our body, and when you hit 45, that's it, baby, you're screwed. No, the reality is that we got a lot going on. So we have to sort of tease apart some of the things that are gone and start to just calm down a little bit and make the, some of the good decisions, starting one by one that can help our body reset to the metabolism, to the fat, to the hormonal interactions that our body needs to give us energy, to give us the shape that we want to have, and to be able to allow us to live and thrive as we get older. Dr. Kyrin Dunston (44:01): Yes, thank you for that very comprehensive, detailed explanation. I think everybody probably got a lot out of that. And really the way you're describing it is that the communication has completely gone offline because of your current metabolic condition. And there are things that you can do to restore proper communication, right? I always say hormones are the communicators and you can get them reestablished. I loved inter, I love intermittent fasting and exercise and many of the other things that you've shared. Thank you so much for sharing this wisdom with everyone. You make it sound very approachable and doable by almost anyone, which it is. And so I love that. We'll definitely have links to your books in the show notes. You have a wonderful Dr. Li's Friday five handout, which we'll have a link to in the show notes. You wanna tell them a little bit about that and where else they can find you online? Dr. William Li (44:59): Yeah. Well, listen, my mission is to get good information about people's bodies and how food interacts with them in a joyful way. That's my mission, is to really impact as many lives as possible. So I have a website, Dr DR William Li l i.com. Please come to visit my website, take a look at the information that's on it. My books Eat to Beat Disease. You can buy them anywhere books are sold. You can order them online very, very easily. I do courses, I have online courses you can find on my website. I run them every month. And this is a deep dive into your body and the foods that can activate your body in ways that are delicious and effective so that you don't have to fear your food. You can love your food and love your health at the same time. And I'm, and I put out newsletters. Dr. William Li (45:44): These are free newsletters that you, or just contain facts and information. And you know, I'm inundated with information all the time. I just wanna get, I wanna do the heavy lifting for the public. For you guys who are listening, I'll, I'll try to, you know, bury the stuff that's BS and I'll try to surface the stuff that's really useful that you should know. The difference between medical research involving drug development and biotech and pharmaceuticals is that, you know, even if you hear about that stuff, you can't do anything about it. Most of the people in the public, but if you, for food is medicine research, when there's something important there is immediacy. I told you that eating, you might be surprised. Soy foods, like at a Mame or tofu can lower the risk of breast cancer, or tomatoes can lower the risk of prostate cancer if you're a man. Hey, guess what? That is something that after you hear that you can make a decision right away lickety split to add something good to your health. And so please know, I welcome people to my community. I've been teaching these online courses. We've got thousands of people from more than 80 countries that have taken my course. And so I, I just love the idea of trying to create as much impact as possible. And thank you for having me on. Well, thank Dr. Kyrin Dunston (46:58): Thank you for being here, and thank you for listening to another episode of The Hormone Prescription with Dr. Kyrin. I know you have loved today's episode. I know you're gonna add strawberries to your diet. I know you're gonna add tomatoes. I know you're gonna look at Dr. Li's books and read them and get some powerful information. Maybe join one of his courses. And really, your most powerful tool when it comes to your health and your hormones is the food that you put in your mouth. I cannot say that you literally are what you eat. Your hormones are what you eat, you are what you eat. So this is the most powerful tool that you have at your disposal to make powerful changes in your health for this year. Like I said, 2024 is the year of self-love. So do it right, make it an action. It is a verb. Take the actions that will get you where you want to be. Thanks so much for joining us, and until next week, peace, love, and hormones, y'all. Dr. Kyrin Dunston (48:00): Thank you so much for listening. I know that incredible vitality occurs for women over 40 when we learn to speak hormones and balance these vital regulators to create the health and the life that we deserve. If you're enjoying this podcast, I'd love it if you give me a review and subscribe. It really does help this podcast out so much. You can visit the hormone prescription.com where we have some free gifts for you, and you can sign up to have a hormone evaluation with me on the podcast to gain clarity into your personal situation. Until next time, remember, take small steps each day to balance your hormones and watch the wonderful changes in your health that begin to unfold for you. Talk to you soon.   ► Get Dr. Li's Friday 5! Top science-backed recommendations, including healing foods, studies, podcasts, supplements, and more. Sign up now to get this FREE newsletter weekly. CLICK HERE.   ► Are you tired of feeling like you're losing control at midlife? Weight gain, low energy, and a decrease in sex drive are all too common. But it doesn't have to be that way. With our Hormone Balance Bliss Challenge, you can reclaim your youth and feel as amazing as you did in college. Our proven system is designed specifically for women at midlife who want to balance their hormones, reset their metabolism, and start seeing real results. Imagine waking up with more energy than ever before. Feeling confident and sexy in your own body. No more mood swings or uncontrollable weight gain – just pure blissful balance throughout menopause. Sign up now for our 7-day challenge and start seeing incredible results within days! Attend daily interactive Q&As with our experts, take assessments to track your progress, and learn the exact steps needed to achieve hormonal harmony. You deserve this – don't wait any longer! CLICK HERE to sign up NOW!   ► Feeling tired? Can't seem to lose weight, no matter how hard you try? It might be time to check your hormones. Most people don't even know that their hormones could be the culprit behind their problems. But at Her Hormone Club, we specialize in hormone testing and treatment. We can help you figure out what's going on with your hormones and get you back on track. We offer advanced hormone testing and treatment from Board Certified Practitioners, so you can feel confident that you're getting the best possible care. Plus, our convenient online consultation process makes it easy to get started. Try Her Hormone Club for 30 days and see how it can help you feel better than before. CLICK HERE.

In this episode of the metabolic classroom, Dr. Ben Bikman takes the helm to explore the multifaceted role of fat tissue as an endocrine organ. He begins by challenging the conventional view of fat tissue as merely a storage depot for energy, emphasizing its crucial role in hormone production and regulation.Dr. Bikman introduces the concept of endocrine organs and highlights the often overlooked status of fat tissue as one such organ. He discusses how fat tissue releases hormones into the bloodstream, exerting significant metabolic effects throughout the body.The lecture delves into sex-specific differences in fat distribution and hormone production, with a focus on the influence of estrogen on fat storage and hormone levels in women. Dr. Bikman further explores the impact of menopause on fat tissue and hormonal changes, shedding light on how shifts in hormone production affect metabolism and fertility.Leptin, the first discovered fat-derived hormone, is dissected in detail by Dr. Bikman, who elucidates its role in appetite regulation, metabolic processes, and fertility. He discusses how excess fat can lead to leptin resistance, compromising its effectiveness in metabolic regulation.Other hormones such as adiponectin, estrogen, TNF alpha, plasminogen activator inhibitor 1 (PAI-1), and T3 are also explored for their metabolic effects and their association with fat cell size.The lecture concludes with a focus on brown adipose tissue and its production of T3, highlighting its role in regulating metabolic rate, particularly in response to stimuli like cold exposure.In summary, Dr. Bikman provides a comprehensive overview of the endocrine functions of adipose tissue, emphasizing the intricate relationship between fat cells and hormone regulation, with implications for metabolism, inflammation, and overall health.00:01 - Introduction to Adipose Tissue as an Endocrine Organ01:07 - Sex-Specific Differences in Fat Distribution03:21 - Impact of Menopause on Fat Tissue and Hormone Production05:45 - Endocrine Effects of Fat Distribution07:58 - Role of Fat Tissue in Aromatization and Estrogen Production10:13 - Impact of Fat Cell Size on Hormone Production12:24 - Detailed Exploration of Leptin14:45 - Examination of Adiponectin and its Metabolic Effects18:17 - TNF Alpha and its Impact on Inflammation and Insulin Resistance21:05 - Plasminogen Activator Inhibitor 1 (PAI-1) and its Implications for Clotting22:16 - Brown Adipose Tissue and its Production of T324:30 - Conclusion and Summary#insulinresistance #metabolicsyndrome #metabolichealth #type2diabetes #type1diabetes #weightloss #intermittentfasting #intermittantfasting #fasting #lowcarb Learn more at: https://www.insuliniq.com Hosted on Acast. See acast.com/privacy for more information.

What is Aged Garlic Extract (A.G.E.) and how is it different from the garlic we eat? Can this one thing actually lower cholesterol, improve insulin resistance, keep bones strong, boost immunity and detoxification, and prevent dementia? We tend to compartmentalize our bodily systems, but they are all connected and the cardiovascular system is at the head of them all. Learn the science behind how A.G.E. can impact all of our systems, how to take it, how much to take, and what the research actually shows, on this episode of Vitality Radio, where Jared interviews Dr. Jim LaValle all about Kyolic Aged Garlic Extract. You'll learn its many benefits and how to use it to improve your overall health. Dr. Jim LaValle is an internationally recognized clinical pharmacist, author, and board-certified clinical nutritionist, with over 40 years of clinical experience. He is considered a renowned expert in his field.Products:Kyolic Aged Garlic ProductsAdditional Information:#278: The Incredible Benefits of Aged Garlic ExtractLipid tests discussed: NMR LipoProfile® TestCardio IQ®Visit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Join Dr. Ernst as he discusses the 5 hormones that you must pay attention to if you want to lose weight – Adiponectin, Ghrelin, Insulin, Leptin & Cortisol.  When balanced these shut off food cravings, engage energy and fat burning. When imbalanced – you guessed it – cravings, fatigue & weight gain! Learn 5 simple steps to balance your hormones and burn fat fast.  See omnystudio.com/listener for privacy information.

References Nutrients. 2021 Feb; 13(2): 413. Advances in Clinical ChemistryVolume 64, 2014, Pages 117-177. Front Physiol. 2020; 11: 796. Int J Mol Sci. 2023 Sep; 24(18): 13942. J Diabetes Investig. 2023. Oct;14(10):1148-1156. Nutrients. 2022 Jun 12;14(12):2438 RNA Biol. 2023; 20(1): 737–749. Clinica Chimica ActaVolume 508, Pages 61-68 Kirwan, Danny. 1971. "Sands of Time" Fleetwood Mac Lp Future Games https://youtu.be/1Jkp34jMeEw?si=fRzdAiA525bHRX5k --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Episode 156: Obesity, Fertility, and PregnancyFuture Dr. Hamilton defines obesity and explains the pathophysiology of obesity and its effects on fertility and pregnancy. Dr. Arreaza adds some input about the impact of epigenetics on newborn babies.  Written by Shelby Hamilton, MS3, American University of the Caribbean School of Medicine. Editing by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition of obesityObesity is a multifactorial chronic disease that is increasing in prevalence across the globe. It can be defined as a body mass index (or BMI) greater than 30 kg/m2. According to the CDC from 2017-March 2020, the prevalence of obesity in United States adults was 41.9%.Classification of obesity by BMI.Obesity can further be divided into three classes: class I which is a BMI between 30-34.9; class II which is a BMI between 35-39.5; and class III which is a BMI greater than 40. We recommend avoiding the term “morbid obesity” because of the negative connotation of the word “morbid.” Class III or severe are better terms in those cases. This classification is based on the individual risk of cardiovascular disease. One of the greatest health consequences affecting individuals with obesity is the cardiovascular effects including hypertension, dyslipidemia, and coronary artery disease. Other effects include insulin resistance and diabetes, cholelithiasis, non-alcoholic fatty liver disease, osteoarthritis, and even depression.How Does Obesity Affect Fertility?Obesity can have an extensive effect on the overall health of an individual. In addition to these commonly discussed effects, obesity can also influence a person's fertility. This is especially observed in women with polycystic Ovary Syndrome (PCOS) who have a greater BMI and also have symptoms of anovulation. Excess adipose tissue plays a role in the effects that obesity has on fertility. White adipose tissue can secrete a specific group of cytokines known as ‘adipokines'. These adipokines include leptin, ghrelin, resistin, visfatin, chemerin, omentin, and adiponectin. With a greater percentage of adipose tissue, there are higher rates of hypothalamic gonadotropin hormonal dysregulation, which can be combined with insulin-related disorders, low sex hormone binding proteins, and high levels of androgens. The combination of these factors can result in decreased ovarian follicle development and decreased progesterone levels.Hormonal changesObesity is an endocrine disorder. One specific adipokine that affects the hypothalamic-gonadotropin axis is chemerin. Chemerin impairs the release of follicle-stimulating hormone (FSH) from the pituitary gland. This reduction in FSH release consequently leads to anovulation, meaning that no egg will be released from an ovarian follicle, contributing to infertility. Shelby: Another adipokine affecting fertility is adiponectin. The receptors of adiponectin are predominantly expressed in reproductive tissues, including the ovaries and endometrium. In individuals with a greater BMI, a decrease in adiponectin secretion has been observed, resulting in decreased stimulation of its receptors, especially in the endometrium, which has been linked to recurrent implantation failure. Adiponectin has also been shown to affect glucose uptake in the liver. With reduced adiponectin levels, there is reduced hepatic glucose uptake, leading to insulin resistance. As tissues become less sensitive to insulin, the body compensates by secreting higher amounts of insulin, leading to hyperinsulinemia. Higher levels of circulating insulin have also been proven to cause hyperandrogenemia in women by blocking the hepatic production of sex hormone-binding globulin. Insulin can also act on the IGF-1 receptors in the theca cells, increasing steroidogenesis, and thus, increasing androgens. With hyperandrogenemia, there is also increased granulosa cell apoptosis as well as increased peripheral conversion of androgens into estrogen. This creates negative feedback to the hypothalamic-pituitary axis to decrease the release of gonadotropins such as FSH which are critical in ovulation.Leptin is another adipokine that is shown to be increased in obesity. Studies on mice have shown that leptin impairs the development of ovarian follicles, resulting in a decrease in ovulation. In these studies, it was also observed that leptin reduces the production of estriol by the granulosa cells in the ovarian follicles as well as increases the rate of apoptosis in granulosa cells, both of which affect ovulation. Leptin decreases hunger, but persons with obesity may be resistant to its effects and that's why they have higher levels than a person with normal weight. They have high levels of leptin but are still hungry because they have leptin resistance.Studies have also shown that the fatty acid composition of follicular fluid found in ovarian follicles also plays a role in fertility. In individuals with a high BMI, this fluid contains high levels of oleic acid, which can cause embryo fragmentation after fertilization occurs. Stearic acid is another fatty acid found in elevated levels in the follicular fluid of women with a greater BMI, which can also affect the quality of the embryo while in the blastomere stage.The bottom line is obesity decreases fertility. It does not mean that patients with obesity will not get pregnant, but it can make it harder to get pregnant. Female patients who are losing weight must be warned about their improved fertility once they start to lose weight.What effect does obesity have on pregnancy?While obesity may make it more difficult for a woman to get pregnant, it is not impossible. However, there are potential risks both to the mother's health as well as the baby's health. Therefore, it is very important to monitor these patients even more carefully.Women who have a greater BMI pre-pregnancy are at a greater risk of developing gestational hypertension. Gestational hypertension is defined as blood pressure greater than 140/90 on more than one reading in the second half of pregnancy. Hypertension during pregnancy can also have serious complications such as kidney failure, stroke, myocardial infarction, or even heart failure. Gestational hypertension can also result in preterm birth or low birth weight.Treatment of mild hypertension in pregnancyRecent studies published in the AFP Journal support the treatment of mild hypertension in pregnancy. It states that “evidence and expert opinion support treating mild chronic hypertension in pregnancy with approved antihypertensives, with a strength of recommendation: B”. There was a randomized control trial with about 2,000 women who were randomized to receive antihypertensive treatment vs no treatment. The treatment group had a lower incidence of preeclampsia with severe features, preterm birth, placental abruption, and neonatal or fetal death. There was not an increase in fetal growth restriction or maternal or neonatal complications. So, it is advisable to treat chronic, mild hypertension in pregnancy, according to the AFP Journal.PreeclampsiaPreeclampsia is another condition that is at a higher risk in women with obesity, which is a more serious manifestation of hypertension in the second half of pregnancy. Along with high blood pressure, there are also effects on the kidneys and liver. Hypertension accompanied by proteinuria is indicative of preeclampsia and should be taken seriously. Preeclampsia can become eclampsia, where the patient also experiences seizures. There is also the risk for stroke, HELLP syndrome, placenta abruption, preterm birth, and fetal growth restriction.Gestational diabetesAnother risk is gestational diabetes. Elevated blood glucose during pregnancy can result in a larger baby and delivery by cesarean. There may also be a greater risk of the mother and child developing diabetes mellitus later on in life.OSAWomen with a greater BMI may also be at risk of developing obstructive sleep apnea during pregnancy. Not only can this result in fatigue but can also contribute to the development of gestational hypertension and preeclampsia.Effect of obesity on the fetusAs mentioned, there are some risks to the fetus in women with a greater pre-pregnancy BMI. There is a greater risk for these babies to be born with birth defects such as congenital heart defects and neural tube defects. Another risk previously discussed is macrosomia, or large for gestational age. Larger babies are also at increased risk for shoulder dystocia during delivery as well as resulting clavicle fractures, brachial plexus injuries, and nerve palsies. Preterm birth is another risk, which also increases the risk of short-term and long-term health complications. Lastly, a higher BMI is directly correlated with the risk of spontaneous abortion or stillbirth.SummaryAs the prevalence of obesity increases, it is important to discuss the health risks that are associated with this disease. In our patients of childbearing age and who may be hoping to conceive, it is even more important to discuss how a higher BMI may affect fertility and pregnancy. While discussing these topics with patients, it is important to try our best to build rapport with the patient so that the discussion is seen more as one of concern and support rather than one of criticism regarding their weight. We may want to help by not only telling patients to “lose weight” or “diet”, but we can also provide them with resources regarding dietary adjustments and ways they can incorporate physical activity into their lives without just telling them to eat less and move more. Stay tuned for our episode on the management of obesity in pregnancy.ConclusionNow we conclude episode number 156, “Obesity, fertility, and pregnancy.” Future Dr. Hamilton explained how obesity affects the hormonal regulation of fertility. She also explained the obstetrical risks associated with obesity. Primary care professionals need to educate our patients about the benefits of preconception weight control. Dr. Arreaza explained that hypertension is a common condition in pregnant patients with obesity and mentioned the benefits of treating mild hypertension in pregnancy. We hope to bring you an episode on the management of obesity in pregnancy soon, so stay tuned! This week we thank Hector Arreaza and Shelby Hamilton. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Gautam, D., Purandare, N., Maxwell, C., Rosser, M., O'Brien, P., Mocanu, E., McKeown, C., Malhotra, J., & McAuliffe, F. (2023) The challenges of obesity for fertility: A FIGO literature review. International Journal of Gynecology & Obstetrics, 160(S1), 50-55. https://doi.org/10.1002/ijgo.14538Pandey, S., Pandey, S., Maheshwari, A., & Bhattacharya, S. (2010). The impact of female obesity on the outcome of fertility treatment. Journal of Human Reproductive Science, 3(2), 62-67. https://doi.org/10.4103/0974-1208.69332.Perreault L. Obesity in adults: Prevalence, screening, and evaluation. In: UpToDate, Pi Sunyer FX (Ed) Wolters Kluwer. https://www.uptodate.com (Accessed on October 6, 2023).Obesity and Pregnancy FAQ, The American College of Obstetricians and Gynecologists (ACOG), https://www.acog.org/womens-health/faqs/obesity-and-pregnancy, Accessed on October 10, 2023.Adult Obesity Facts, Centers for Disease Control and Prevention (CDC), https://www.cdc.gov/obesity/data/adult.html, Accessed on October 7, 2023. Dresang L, Vellardita L. Should Medication Be Prescribed for Mild Chronic Hypertension in Pregnancy?. Am Fam Physician. 2023;108(4):411-412. Royalty-free music used for this episode: "I Think We Have a Chance."  downloaded on November 11, 2023,  from https://www.videvo.net/.

In this podcast, Nurse Doza shares his passion for discussing weight loss and offers helpful tips for those on a weight loss journey. He talks about the importance of finding a supportive community, provides recommendations for supplements and blood work, and highlights the benefits of taking supplements.   TIMESTAMPS: 00:00 START 02:50 Find a supportive weight loss community. 05:29 Importance of community for weight loss. 10:58 Sleep is crucial for weight loss. 19:17 Resveratrol helps regulate insulin. 24:29 Calorie restriction aids weight loss. 34:09 Fasting can help with weight loss and prediabetes. 39:23 Cold exposure promotes weight loss. 44:33 Adiponectin promotes prevention of diseases. 49:26 Supplements for weight loss   Before we dive into today's exciting topic on weight loss strategies, let me introduce you to "Mitochondriac." It's a cutting-edge methylated resveratrol supplement that's gaining popularity for supporting metabolism and cellular health. If you've been on the lookout for a supplement to support your weight loss journey, don't miss out on Mitochondriac! Click the link below to explore more. https://www.mswnutrition.com/products/mitochondriac/?ref=nursedoza   Show Notes: 1. The Importance of Community in Weight Loss Finding a community that supports your weight loss journey can be pivotal for success¹. Reference: Diabetes Journals - Obesity Management¹. 2. The Sleep-Weight Connection Obesity is a significant component contributing to sleep apnea¹. Lifestyle factors, such as diet and exercise, play crucial roles in managing obesity¹. Weight change directly correlates with sleep disordered breathing¹. Short sleep duration and prolonged working hours are linked with obesity in certain demographics¹. Sleep deprivation can alter hunger hormone levels, predisposing individuals to obesity¹. Reference: NCBI - Sleep and Obesity¹. 3. Supplement Spotlight: Resveratrol Resveratrol may improve insulin sensitivity and has potential in diabetes management¹. Resveratrol mimics caloric restriction, promotes energy expenditure, and lowers body fat³. References: PubMed - Resveratrol and Diabetes¹. NCBI - Resveratrol Metabolic Effects². NCBI - Resveratrol Anti-obesity Bioactive³. 4. Diet Recommendation: Caloric Restriction (CR) Diet Caloric restriction has shown to be more effective than fat restriction¹. CR improves lifespan, health span, insulin sensitivity, and reduces inflammation⁴. The benefits of CR are amplified when combined with exercise, especially for active individuals³. References: PubMed - Dietary Fat Restriction vs. Caloric Restriction¹. PubMed - Dietary Restriction for Obesity². Frontiers in Physiology - CR and Exercise³. NCBI - Benefits of Caloric Restriction⁴. 5. Harnessing Brown Fat for Weight Loss Brown adipose tissue (BAT) has potential therapeutic benefits due to its energy-expending properties². Cold exposure activates BAT, leading to increased energy expenditure². Adipokines like Adiponectin and Leptin play roles in obesity and energy balance². References: NCBI - Human Brown Adipose Tissue¹. NCBI - BAT, Adipokines, and Obesity². NCBI - Leptin and Its Role³. Mitochondriac To wrap things up, I want to give a shoutout once again to "Mitochondriac." It's not just another supplement; it's a game-changer. Packed with the power of methylated resveratrol, Mitochondriac is here to support your metabolic health and weight loss efforts. Ready to feel the difference? Click on the link below and give Mitochondriac a try. Your body will thank you! https://www.mswnutrition.com/products/mitochondriac/?ref=nursedoza

In this podcast, Nurse Doza discusses the importance of adiponectin, a hormone produced by fat cells. Adiponectin can provide insights into overall metabolism, heart health, brain health, and protection against diabetes mellitus. The optimal range for adiponectin levels is above 10 for men and above 13 for women. Monitoring adiponectin levels annually is recommended, and there are ways to improve it.  

Many of us think of adipose tissue as just a place to store excess fat to be used for energy. However, adipose tissue is very biologically active and secretes some important hormones and mediators called adipokines. These messengers help regulate glucose and lipid metabolism, control hunger, and affect insulin levels. That being said, ALL of our hormones work together like a symphony – cortisol, thyroid hormones, sex hormones, and don't forget the adipokines. In today's episode, we discuss important bioactive messengers created by our fat tissue (leptin and adiponectin), how they affect us systemically, and strategies to optimize them. Today on The Lab Report: 3:40 Adipose tissue, adipokines, and types of fat 7:40 What are adipokines? 10:25 Adiponectin does great things 13:00 How to increase adiponectin 14:20 Better Know a Biomarker – Leptin! 17:40 Obesity and leptin resistance 19:25 Treating leptin resistance 21:35 Leptin vs. ghrelin 23:15 Adiponectin/leptin ratio Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week's episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don't forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Drs Michael S. Saag and Roger Bedimo discuss weight gain after starting antiretroviral therapy, including risk factors, long-term outcomes, and patients' well-being. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986507). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Weight Gain on INSTI-Based HIV Antiretrovirals https://www.medscape.com/viewarticle/916095#vp_2 Lipodystrophy in HIV Clinical Presentation https://emedicine.medscape.com/article/1082199-clinical Protease Inhibitors' Metabolic Side Effects: Cholesterol, Triglycerides, Blood Sugar, and 'Crix Belly.' Interview With Lisa Capaldini, MD. Interview by John S. James https://pubmed.ncbi.nlm.nih.gov/11364559/ Reduced Survival After Serious Non-AIDS Complications https://www.medscape.com/viewarticle/721773 HIV Protease Inhibitor-Related Lipodystrophy Syndrome https://pubmed.ncbi.nlm.nih.gov/10860898/ Antiretroviral Therapy for HIV Infection https://emedicine.medscape.com/article/1533218-overview Integrase Strand Transfer Inhibitor (INSTI) https://clinicalinfo.hiv.gov/en/glossary/integrase-strand-transfer-inhibitor-insti Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) https://clinicalinfo.hiv.gov/en/glossary/non-nucleoside-reverse-transcriptase-inhibitor-nnrti Strategies to Prevent Weight Gain Among Adults https://pubmed.ncbi.nlm.nih.gov/23638485/ Tenofovir Alafenamide (TAF) Clinical Pharmacology https://pubmed.ncbi.nlm.nih.gov/35146360/ Associations Between Integrase Strand-Transfer Inhibitors and Cardiovascular Disease in People Living With HIV: A Multicentre Prospective Study From the RESPOND Cohort Consortium https://pubmed.ncbi.nlm.nih.gov/35688166/ Adipokines, Weight Gain and Metabolic and Inflammatory Markers After Antiretroviral Therapy Initiation: AIDS Clinical Trials Group (ACTG) A5260s https://pubmed.ncbi.nlm.nih.gov/34117756/ Is Tenofovir Disoproxil Fumarate Associated With Weight Loss? https://pubmed.ncbi.nlm.nih.gov/34848586/ Switching From Boosted PIs to Dolutegravir Decreases Soluble CD14 and Adiponectin in High Cardiovascular Risk People Living With HIV https://pubmed.ncbi.nlm.nih.gov/34120186/ Adiponectin: A Fat Cell Hormone That Promotes Insulin Sensitivity https://www.medscape.org/viewarticle/438373 Glucagon-like Peptide-1 Analogues: An Overview https://pubmed.ncbi.nlm.nih.gov/23869296/ Dolutegravir Plus Two Different Prodrugs of Tenofovir to Treat HIV https://pubmed.ncbi.nlm.nih.gov/31339677/ Weight and Metabolic Changes After Switching From Tenofovir Alafenamide (TAF)/Emtricitabine (FTC)+Dolutegravir (DTG), Tenofovir Disoproxil Fumarate (TDF)/FTC+DTG and TDF/FTC/Efavirenz (EFV) to TDF/Lamivudine (3TC)/DTG https://pubmed.ncbi.nlm.nih.gov/36519389/ The ADVANCE Study: A Groundbreaking Trial to Evaluate a Candidate Universal Antiretroviral Regimen https://pubmed.ncbi.nlm.nih.gov/28538284/

Cold water therapy is all the rage at the moment, but does it work? Well yes it absolutely does. Evidence shows that cold water therapy can help you to lose weight, burn fat, improve your immune system, reduce autoimmune conditions, help with pain and inflammation, can help to put you into ketosis, and even help to regulate your hormones.The optimum temperature is around 10-15 degrees celsius (50-60 fahrenheiht), and the optimum time to spend in the water is around 2-3 minutes, but you can spend longer if you can tolerate it.Cold water helps to activate brown fat (brown adipose tissue) which can burn calories to produce heat and therefore help to lose weight by burning our fat stores. Cold water therapy also increases the production of a hormone called Adiponectin which helps us to burn fat and stay lean. Cold water therapy can also help to boost our immune system and reduce inflammation.Link to my new health courses: https://drsuresh.teachable.comNew 30 day carnivore challenge - how to start a carnivore diet - out now! Link above._Welcome to The Meat Medic Podcast. I'm your host Dr Suresh Khirwadkar. I'm a GP and Lifestyle Physician and I'm a practicing carnivore. I've had great success myself and with patients by following a carnivore diet, and want to spread the word about how to achieve optimal health through diet, nutrition and lifestyle changes._Time Stamps00:00 Intro02:15 How long to spend in the cold water?03:15 Optimum temperature of the water 04:13 Weight loss and fat burning07:10 Ketosis07:30 Immune function support08:00 Reduce inflammation09:25 The benefit of a hot shower before bedJoin this channel:If you want to join this channel and my podcast for exclusive bonus content, early access, and private support via discord channel, please join as a member or on Patreon.https://themeatmedic.com/memberNewsletter sign up available https://themeatmedic.com/newsletterSocialWebsite and booking info: https://drsuresh.com.auFacebook: @drsureshkhirwadkarTwitter: @themeatmedicInstagram: @themeatmedicYouTube: @themeatmedicTikTok: @drsureshkhirwadkarLink Tree: https://linktr.ee/drsureshkhirwadkar_Do you have a story to share about your health, or success story losing weight or following a low carb / keto / carnivore diet? Please get in touch by social media or book to come on to my podcast at https://themeatmedic.com/booking_DisclaimerAll health advice is general in nature and is not intended to be individualized health advice. Always see your personal doctor if you are concerned about your healthAny reference to drugs or drug taking is strictly for educational purposes only and does not encourage the use of illicit or illegal substances.Hashtags#themeatmedic #drsuresh #medicaladvice #lifestyle #carnivore #lowcarb #keto #fyp #dyor #diet #dietaryadvice #meat #carnivorediet #coldwatertherapy #coldwater #weightloss #burnfat #fatburn #fatburning #howtoloseweight Mentioned in this episode:Post credits

In this episode of ReInvent Healthcare, we will discuss the relationship between lack of sleep and appetite. We go in-depth into the different hormones that are affected by sleep and how these can trigger hunger. We will also discuss the different areas in the brain that can affect appetite.    IN THIS EPISODE: [04:30] Sleep deprivation and increased Ghrelin production resulting in food cravings [05:30] Lower Leptin levels and increased food consumption [7:00] The importance of Adiponectin [9:45] Neuropeptide Y appetite stimulation [12:00] Lack of sleep and the areas in the brain that affect appetite KEY TAKEAWAYS: Children need at least 11 hours of sleep. Studies have shown that those with lack of sleep have a higher risk of obesity.  Sleep deprivation significantly decreases activity in appetite evaluation regions within the frontal cortex and can therefore trigger hunger Lack of sleep can induce high levels of cortisol and can lead to intense cravings, resulting in binge eating   RESOURCES: www.reinventhealthcare.com/sleep Get the Magic Questions www.INEMethod.com IRSPT Program FREE Sleep Resource Guide Food Checklist to Restore Insulin Sensitivity Impact of Sleep Debt on Metabolic Endocrine Function Reference Articles Impact of Food Deprivation on Food Desire Sleep Deprivation and Central Appetite Regulation Sleep Duration Patterns and Overweight/Obesity at age 6 Sleep and Overeating 

Joel Greene har drevet med olympiske løft og styrketrening, han gjorde Keto og periodisk faste på 90 -tallet, er en old school biohacker og har lært konsekvensene av diettene han holdt på med, at de ikke virket og i dag er han spesialisert seg innen immunologi, fettforbrenning og hvordan immunmekanismene påvirker fettforbrenningen og hormoner som styrer hva vi spiser. Joel Greene bor og coacher folk fra hele verden fra San Clemente i California. Hans kunnskap er så avansert og ny for de fleste som forsker på helse, fitness, styrketrening, muskler og fettforbrenning. Dagens episode handler om FATBURN. Joel var selv sprinter og har brukt kroppen sin som eget studie for å forstå hva som virker og ikke virker - "longterm". Key Notes er: When - What and How. Man kan ikke Et av de største problemen ei fitness og slankeverdne er at folk går opp i vekt etter at fettcelnnen mister fett, kroppen reagerer med en overlevelsesmekanisme som gjør at fettceller blir fylt opp igjen. Kroppen lærer at når den er sulten må finne strategier, en immunrespons skjer der cellene blir skadet når man slanker seg, det er lite fokus på hva som skjer etterpå, etter endt slanke periode. Når man gjør for mye av det samme lenge (dietter) så kan det skje en immunrespons, en allergi mot en viss matvare, fordi det negative aspektet ved maten tar plass. Å spise sesongrelatert er bra i forhold til hormoner som også påvirker sult og metthetsfølelse. Vi snakker om kald eksponering, hva skjer og hvordan virker dette når man bader og kulde eksponerer seg for mye? Hva skjer i tarmene? og hvordan påvirker dette for eksempel Akkermansia? Dette er en anti-kalori bakterie som vi trenger for å holde oss slanke, så ikke bade i kulde hver dag. Variasjon er et nøkkelord, mikse det med kulde og sauna. Poenget er at alt virker ikke likt alltid og hele veien, det gjelder medisiner, mat og vaner... Energi gap er postfatloss, du må droppe endel kalorier etter en endt diett, men kroppen vil ha mer, men den trenger ikke mer. Joels program guider deg til hvordan du skal spise for å unngå dette, med mer proteiner og store frokoster med carbs for å dempe sulten til å spise mye etter fatloss og balansere Ghrelin(kortids) og Leptin (langtids). Adiponectin er et fetthormon som har påvirkning på insulin og muskler, denne må stimuleres etter endt diett periode. Man trenger også mat som gir næring til Commensal bakteriene etter en slankeperiode, og immunsystemet må styrkes. Supplementer: Berberine som stimulerer FGF21 som man før tenkte på som et sulthormon, men i dag snakkes det mer om FGF21 som et stresshormonet. sees også når folk spiser mye, altså både faste og spise mye. Dette hormonet vil stimuleres etter en endt fettloss periode. Fatparadox er et tema Joel er opptatt av fordi "slanke" industrien har ikke tatt høyde for hva som skjer etterpå. Mange system i kroppen jobber sammen for at du ikke skal krympe mer fett celler. Og her er paradokset. I episoden lærer dere ellers om hvordan makrofagene virker i cellene og påvirker immunsystemet, betennelser og kroppsfett. Hva er leptin resistance og insulin resistance. Og ikke minst tips om Joels super effektive super sprint trenings 90 dagers Challenge, korte intense intervaller som bygger styrke, muskler og utholdenhet. Denne heter The Young Body Challenge og den finner du på Joels Instagram konto. For tiden studerer Monica med Joel Greene og utdanner seg i hans Immune centric Coach system, men han har mange online kurs og veiledning. Du finner Joel Greene her: https://www.veepnutrition.com Her er hans 30 dagers Immune centric intensive fatburn program: https://www.veepnutrition.com/immune-centric-fat-loss Her finner dere Joel Greene på instagram: @realjoelgreene

Adiponectin is what helps you to burn fat! Find out everything you need to know about this, not talked about, hormone that could be stopping you from losing weight.   Download the podcast Wits & Weights: Strength and Nutrition for Skeptics using your favorite podcast app, or go to witsandweights.com/podcast to listen and get motivated to change your life. Download the FREE"Protein Power Transformation Program" at witsandweights.com. Do you have a question you would like for me to answer in my next Q&A podcast? If so please fill out this form.  Purchase your home Hormone Test Kits here.  Are struggling with perimenopausal symptoms? Hot flashes, weight gain, weight loss resistance, low libido?  Check out the most comprehensive and affordable peri and post-menopause monthly course OnTrack. OnTrack is a group coaching program to help you balance your hormones, lose weight and sail through peri and post-menopause at a fraction of what it costs to work with me privately.   Karen Martel, Certified Hormone Specialist & Transformational Nutrition Coach and weight loss expert.  Visit https://karenmartel.com/  Karen's Facebook Karen's Instagram

Have you ever wondered why it's simple for some people to lose weight while others struggle? Or how some people can eat all the calories they want and never gain a pound… Well, all of this can be clearly explained through the science of metabolism and what causes some people to “get stuck.” On today's #CabralConcept 1286 I want to share with you the 8 ways to boost adiponectin (your fat burning hormone) – Enjoy the show! - - - Show Notes & Resources: http://StephenCabral.com/1286 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Stress, Sleep & Hormones Test (Run your adrenal & hormone levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels)

***JOIN THE FASTING LIFESTYLE CHALLENGE THAT STARTS APRIL 13, 2022! -New to fasting or want to get back on track? -Struggling to break through a plateau? -Ready to finally stop obsessing about your diet? We'll teach you how to finally win for good and use 'fast cycling' to achieve uncommon results! Join us April 13th for the Fasting Lifestyle Challenge!  REGISTER HERE! https://www.thefastingforlife.com/live   In this episode, Dr. Scott and Tommy discuss types of fat, how and why they're important, and why fasting can be an incredible tool to get some pretty amazing results, what is visceral fat and why is it important, ramadan fasting and much more.   Research Links: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473928/ https://pubmed.ncbi.nlm.nih.gov/23687099/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122042/ https://onlinelibrary.wiley.com/doi/10.1038/oby.2002.67 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318440/ https://my.clevelandclinic.org/health/articles/22439-adiponectin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500349/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800358/   Show Transcript: www.thefastingforlife.com/blog   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it makes a difference in helping bring you the best original content each week. We also really enjoy reading them!   Sign up for the Fasting For Life newsletter at www.thefastingforlife.com   Join the Community on Facebook!   Follow Fasting For Life: www.facebook.com/thefastingforlife www.instagram.com/thefastingforlife

Drinking beetroot juice reduces high blood pressure, trial shows Queen Mary University (UK), January 20, 2022   One glass of beetroot juice a day is enough to significantly reduce blood pressure in patients with high blood pressure, conclude researchers who conducted a placebo-controlled trial in dozens of patients.   "This interesting study builds on previous research by this team and finds that a daily glass of beetroot juice can lower blood pressure in people with hypertension - even those whose high blood pressure was not controlled by drug treatment." Beetroot contains high levels of inorganic nitrate. Other leafy vegetables - such as lettuce and cabbage - also have high levels of the compound, which they take up from the soil through their roots. In the human body, inorganic nitrate converts to nitric oxide, which relaxes and dilates blood vessels. The patients in the active supplement group also experienced a 20% or so improvement in blood vessel dilation capacity and their artery stiffness reduced by around 10%. Studies show such changes are linked to reduced risk of heart disease.     Researchers recommend clinical trials for CBD to prevent COVID-19 based on promising animal data University of Chicago Medical Center, January 20 2022 An interdisciplinary team of researchers from the University of Chicago has found evidence that cannabidiol (CBD), a product of the cannabis plant, can inhibit infection by SARS-CoV-2 in human cells and in mice. The study, published on January 20, 2022, in Science Advances, found that CBD showed a significant negative association with SARS-CoV-2 positive tests in a national sample of medical records of patients taking the FDA-approved drug for treating epilepsy. The researchers now say that clinical trials should be done to determine whether CBD could eventually be used as a preventative or early treatment for COVID-19. They caution, however, that the COVID-blocking effects of CBD come only from a high purity, specially formulated dose taken in specific situations. The study's findings do not suggest that consuming commercially available products with CBD additives that vary in potency and quality can prevent COVID-19. "CBD has anti-inflammatory effects, so we thought that maybe it would stop the second phase of COVID infection involving the immune system, the so-called 'cytokine storm.' Surprisingly, it directly inhibited viral replication in lung cells," said Marsha Rosner, Ph.D., Charles B. Huggins Professor in the Ben May Department of Cancer Research and a senior author of the study. To see this effect, the researchers first treated human lung cells with a non-toxic dose of CBD for two hours before exposing the cells to SARS-CoV-2 and monitoring them for the virus and the viral spike protein. They found that above a certain threshold concentration, CBD inhibited the virus's ability to replicate. Further investigation found that CBD had the same effect in two other types of cells and for three variants of SARS-CoV-2 in addition to the original strain. CBD did not affect the ability of SARS-CoV-2 to enter the cell. Instead, CBD was effective at blocking replication early in the infection cycle and six hours after the virus had already infected the cell.   Mediterranean diet associated with a lower risk of mortality in older adults University of Barcelona (Spain), January 20, 2022 A greater adherence to the Mediterranean diet which had been assessed through an index made with biomarkers during a 20-year scientific monitoring is associated with a lower mortality in adults over 65.  The study is based on the InCHIANTI project, conducted in the region of the Italian Tuscany, a study that has been carried out during 20 years in a total of 642 participants (56 percent women) aged over 65 or more and which enabled researchers to obtain complete data on food biomarkers. In the study, researchers chose the reference levels of the following dietary biomarkers in the urine: total polyphenols and resveratrol metabolites (from grape intake) and presents in plasma, plasma carotenoids, selenium, vitamin B12, fatty acids and their proportion of monounsaturated and saturated fatty acids. Using a predictive model, they assessed the associations of the Mediterranean diet index and the food-frequency questionnaire (FFQ) with mortality. Once the models were analyzed, the score of the Mediterranean diet using the biomarkers was inversely associated with all causes of death.   The best way to fix a sad mood: Whatever you think works best Ohio State University, January 20, 2022 What's the best way to improve a sad mood? It may be whatever skill you think you're best at, a new study suggests. Think you're good at mindfulness techniques? Then that may work best for you. Or do you believe a more cognitive approach is your strength? Then use that. Researchers found that people who were in a sad mood improved more quickly when they used a mood-improving method that they were told was their strongest skill. These participants improved more quickly than people asked to use a skill that they were told was a relative weakness. "We only studied mindfulness and cognitive skills here, but there are a variety of approaches to improving mental health," he said. "The ones that you think would work best for you probably will indeed work best."   Tomato Juice Reduces Inflammation and Waist Size In Women Tufts and Boston universities,  January 20, 2022   A daily glass of tomato juice is known to significantly lower cardiovascular disease, cancer and even osteoporosis. A new study is now showing that it also has a direct effect on waist circumference, cholesterol, and markers of inflammation in women.

   Data from 30 women revealed that a daily glass of 280 mL of tomato juice containing 32.5 mg of lycopene was associated with an average reduction in waist circumference of 1.6 cm and more than one pound kg reduction in body weight.   The tomato juice supplements were associated with a 22% decrease in levels of monocyte chemoattractant protein-1 (MCP-1), a potent marker of inflammation, and a 25% increase in adiponectin levels, according to findings published in Nutrition . Adiponectin is a hormone released from fat cells, which plays an important role in the regulation of insulin sensitivity and energy.     Does coffee help protect against endometrial cancer? Chinese Academy of Medical Sciences, January 20, 2022   Higher coffee consumption is linked with a lower risk of endometrial cancer, a type of cancer that begins in the lining of uterus, according to an analysis of relevant studies published to date. Also, caffeinated coffee may provide better protection than decaffeinated coffee. The analysis, which appears in the Journal of Obstetrics and Gynaecology Research, included 24 studies on coffee intake with 9,833 new cases of endometrial cancer occurring in 699,234 individuals. People in the highest category of coffee intake had a 29% lower relative risk of developing endometrial cancer than those in the lowest category.     LETTER RE. WIKIPEDIA To the Victims of Wikipedia's Libel, You are by now fully aware that the online encyclopedia Wikipedia has been exceedingly antagonistic against your careers and your personal stances on many issues that directly affect the principles of democracy, freedom of speech, medical choice and personal well-being. In particular, medical professionals and advocates for natural health have been categorically ridiculed, libeled and their careers canceled. This disturbing trend continues to worsen. Sadly, editors who support globalist agendas and the pharmaceutical industry now far outnumber those trying to make efforts to write opposing views in the spirit of neutrality and objectivity. Repeatedly I hear that efforts to correct the numerous inaccuracies, misinformation, biases and derogatory terms on biographical entries are exercises in futility. The encyclopedia's parent organization, the WikiMedia Foundation, has been habitually unresponsive to demands for corrections and refuses to enforce its volunteer editors to abide by its editorial rules of neutrality when dealing with subjects regarding alternative medicine and the biographies of its advocates. Since Wikipedia is ranked in the top three websites that people turn to for information about current events, medicine and general health, and for biographical information about public figures and contemporary voices, I am convinced that numerous people have been wrongfully misled and dissuaded from seeking reliable information on Wikipedia. The Foundation refuses to assume responsibility and to be held accountable for the abuse being perpetrated by individual editors and groups promoting antagonistic ideologies. The consequence has been that your reputations have been seriously undermined and damaged. Over the years, voluminous complaints have been communicated and/or filed to the Foundation, including lawsuits, about the gross violations in Wikipedia's editorial policies, misinformation and inflammatory and potentially libelous language. Based upon the evidence and my repeated encounters with the Wikimedia Foundation's in-house and outside attorneys it is my belief that the encyclopedia's efforts to advance a globalist and corporate-friendly ideology may be intentional. It is not merely the hundreds of thousands of physicians worldwide who rely on peer-reviewed supported therapies, but Wikipedia's animus has spread far and wide to assure that its users have no objective choice over sound information about personal religious, socio-political or health decisions. Robert Kennedy Jr, Sharyl Attkinsson, Rupert Sheldrake, Abby Martin, Julian Assange and literally hundreds of others who have exemplary careers and who have been repeatedly accurate have had their accomplishments scrubbed and destroyed. Anonymous Wikipedia editors have made it their personal mission to paint them as promoters of misinformation and conspiracy theories should be verbally ostracized.  The Foundation recently hired a new Executive Director, Maryam Iskander. Although I originally hoped this may signal a positive change in Wikipedia's neutrality policies and new efforts would be forthcoming to rein in radical ideological editors, I am no longer optimistic. Ms Iskander happens to be an upcoming leader aligned with the World Economic Forum. I now have every reason to believe that Wikipedia will increasingly steer its editing closer towards the Great Reset agenda.  Despite ours and others' numerous attempts and failures to deal directly with the Foundation's legal department and Board members to have misinformation corrected or biographies eliminated altogether, there are options that can be pursued by those who have been ridiculed, shamed and wrongfully characterized on Wikipedia. Each of us has lost something due to Wikipedia's denial of truth. However, we can continue to record our personal achievements on our websites and through our allies.  Second, we can continue to investigate and write critical essays and analyses exposing Wikipedia's biases, negligence, misinformation, political partisanship, smear campaigns and its financial collaborations with private anti-democratic entities, corporate industries and government agencies.  With the growing consolidation of various neoliberal and globalist Wikipedia editors' presence, including the Skeptics of scientific materialism, into a reactionary movement, this is a critical moment for us to take the upper hand by cooperating together to challenge Wikipedia wherever there is demonstrable proof of ill-will and gross bias. I believe a grassroots national campaign to “Walk Away From Wikipedia” would capture the Foundation's attention. For our part we have written over 70 articles exposing the encyclopedia, its senior editors and the Foundation's corporate relations. Yet there remains much more to uncover and report.    Best regards,   Gary Null, PhD

Effects of strawberries on bone biomarkers in pre- and stage 1-hypertensive postmenopausal women Florida State University Postmenopausal women experience an increase in bone remodeling with the rate of bone resorption superseding the rate of bone formation. This results in a net bone loss with a subsequent increased risk for osteoporosis and fractures. Strawberries are rich in polyphenols, which have been shown to have anti-hypertensive and bone-protective properties. Thus, we examined whether daily intake of strawberries would positively affect biomarkers of bone metabolism in postmenopausal women with pre- and stage 1-hypertension. After eight weeks, osteocalcin increased in the 50 g FDSP group with a large effect size (d = 0.6) when compared to the placebo-control group. Adiponectin increased by 5% and 6% in the 25 g and 50 g FDSP groups, respectively, while it declined in the placebo-control group by 25% (P = 0.03 for time-by-treatment interaction). Our findings suggest that consumption of 25 g FDSP increases IGF-1 in postmenopausal women with pre- and stage 1-hypertension.    Dietary supplement use by individuals living with and beyond cancer University College London, December 20, 2021 New research indicates that many individuals living with and beyond cancer use dietary supplements, often with the belief that the products will reduce the risk of cancer recurrence. Published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings reveal a need for health care professionals to provide advice and clarity to patients about the appropriate use of dietary supplements. To explore factors associated with dietary supplement use in cancer survivors, Rana Conway, PhD, RNutr, of University College London (UCL), and her colleagues studied 1,049 adults who had been diagnosed with breast, prostate, or colorectal cancer in the United Kingdom.  Among the major findings: 40% of participants took dietary supplements. 19% of participants believed that dietary supplements could reduce the risk of cancer recurrence. Women, participants meeting five-a-day fruit and vegetable recommendations, and those believing that dietary supplements were important for reducing the risk of cancer recurrence were more likely to use dietary supplements. Participants with obesity were less likely to use dietary supplements. Fish oils were the most commonly used dietary supplements, taken by 13% of participants. Calcium with or without vitamin D were the supplements most commonly used by individuals with breast cancer, taken by 15%.   Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial Nutrition Research Centre Ireland, December 20, 2021 Accumulating evidence suggests that omega-3 fatty acids (ω-3FAs), carotenoids and vitamin E can improve cognitive performance. However, their collective impact on cognition has not yet been investigated in healthy individuals. This study investigated the combined effect of ω-3FA, carotenoid and vitamin E supplementation on the cognitive performance of older adults. Methods Cognitively healthy individuals aged ≥65 years consumed daily 1 g fish oil (of which 430 mg docosahexaenoic acid, 90 mg eicosapentaenoic acid), 22 mg carotenoids (10 mg lutein, 10 mg meso-zeaxanthin, 2 mg zeaxanthin) and 15 mg vitamin E or placebo for 24 months in a double-blind, placebo-controlled, randomised clinical trial. These results support a biologically plausible rationale whereby these nutrients work synergistically, and in a dose-dependent manner, to improve working memory in cognitively healthy older adults. Increasing nutritional intake of carotenoids and ω-3FAs may prove beneficial in reducing cognitive decline and dementia risk in later life.   A high-fiber diet may improve the response of melanoma patients to immunotherapy University of Texas and  National Cancer Institute, December 23, 2021 A diet rich in fiber may help some people being treated for melanoma respond to immunotherapy treatment by influencing the gut microbiome, according to a new study led by researchers at the Center for Cancer Research at the National Cancer Institute (NCI), part of the National Institutes of Health, and the University of Texas MD Anderson Cancer Center.  Among patients with advanced melanoma who underwent immunotherapy with immune checkpoint blockers, those who consumed at least 20 grams a day of dietary fiber survived the longest without their disease progressing. In contrast, use of probiotic supplements appeared to lessen somewhat the effectiveness of immune checkpoint blocker regimens. Probiotics are live microorganisms typically consumed as a supplement to improve gut health. Among the 128 patients whose dietary fiber intake was known, those who reported consuming at least 20 grams of dietary fiber per day (an amount the researchers designated as "sufficient" for the purposes of this study) lived longer without their cancer progressing than those who consumed less dietary fiber. Every 5-gram increase in daily dietary fiber intake corresponded to a 30% lower risk of progression of the disease. Dr. Trinchieri noted that one possible mechanism through which dietary fiber exerts its beneficial effect is by increasing the types of bacteria in the gut, such as Ruminococcaceae, that produce high levels of certain short-chain fatty acids that have an antitumor effect.   Could meditation strengthen your immune system? University of Florida's College of Medicine, December 23, 2021 Meditation done at an intense level may bring a significant boost to the inner workings of your immune system. That analysis suggested that meditation boosted the activity of hundreds of genes known to be directly involved in regulating immune response. But the researchers stressed that their study involved 10-hour daily marathon meditation sessions conducted for eight straight days in total silence. In the real world, most people would be hard-pressed to replicate those methods.  The eight-day retreat provided all participants with vegan cuisine, and all followed a regular sleep schedule. Meditation sessions lasted 10 hours a day and were conducted in silence. The result: Three months after the retreat's conclusion, Chandran and his colleagues found an uptick in activity involving 220 immune-related genes, including 68 genes engaged in so-called "interferon signaling." The study authors pointed out that such signaling can be key to mounting an effective defense against various health conditions—including cancer, multiple sclerosis or even COVID-19—given that interferon proteins effectively act as immune system triggers.  Among seriously ill COVID-19 patients in particular, Chandran noted, insufficient interferon activity has been cited as a problem.  He explained that nearly all (97%) of interferon "response genes" were found to be activated following the mediation retreat. But relying on publicly available gene activity data derived from COVID-19 patients, Chandran and his colleagues reported that figure to be 76% among those with mild COVID illness, and just 31% among the most severe cases. At the same time, the investigators found that while inflammation-signaling gene activity remained stable following in-depth meditation, such signaling shot up among severely ill COVID-19 patients.   Even light-intensity exercise might reduce dementia risk Yonsei University College of Medicine (South Korea), December 22, 2021 In a new study, researchers have identified an association between light-intensity physical exercise in older adults and a reduced risk of dementia. In the present study, researchers investigated whether there was an association between doing light-intensity physical exercise and a reduced risk of developing dementia in older adults. The study involved 62,286 participants who were 65 years or older, did not have a dementia diagnosis, and had medical records in the Korean National Health Insurance Service database.  Researchers gathered data between January 2009 and December 2012 and tracked the participants until the end of December 2013. They completed data analysis from July 2020 to January 2021. After a median follow-up period of 42 months, the researchers noted how many participants developed dementia. They found that insufficiently active participants had a 10% reduced risk of developing dementia compared with inactive participants.  Active participants had a 20% reduced risk, while highly active participants had a 28% reduced risk.   Fast-food consumption linked to lower test score gains in 8th graders The more children ate in 5th grade, the slower their academic growth by 8th grade Ohio State University, December 22, 2021   The amount of fast food children eat may be linked to how well they do in school, a new nationwide study suggests. Researchers found that the more frequently children reported eating fast food in fifth grade, the lower their growth in reading, math, and science test scores by the time they reached eighth grade. Students who ate the most fast food had test score gains that were up to about 20 percent lower than those who didn't eat any fast food, said Kelly Purtell, lead author of the study and assistant professor of human sciences at The Ohio State University. The results remained even after the researchers took into account a wide variety of other factors that may have explained why those with high fast-food consumption might have lower test scores, including how much they exercised, how much television they watched, what other food they ate, their family's socioeconomic status and characteristics of their neighborhood and school. This study included about 11,740 students. They were tested in reading/literacy, mathematics and science in both fifth and eighth grades. They also completed a food consumption questionnaire in fifth grade.Children who ate fast food four to six times per week or every day showed significantly lower gains in all three achievement areas compared to children who did not eat any fast food the week before the survey. However, children who ate fast food just one to three times a week had lower academic growth compared to non-eaters in only one subject, math.

3 Hormones That Prevent Weight Loss Thanks to the modern sedentary lifestyle, obesity is one of the most common public health issues these days. A common complaint from people these days is unstoppable weight gain. Almost 42.4 percent of adults in America are overweight.  From the obese population of the U.S., half of them are at a high risk of developing chronic conditions such as metabolic syndrome, diabetes, and cardiovascular diseases. Along with this, the modern lifestyle has also normalized stress, increased fatigue, and brain fog—conditions people try to live with; till they can't take it anymore.  If you are someone with weight loss issues, facing fatigue and memory loss, wondering why you aren't losing weight, this blog is for you. You will learn about specific hormones that you should get checked first thing while facing weight loss issues, understand their function and dysfunction, and how to resolve it.  In this blog, we'll be delving into three hormones that might be contributing to your weight gain: Leptin  Adiponectin  Cortisol Grab a pen and notebook, and let's get started! Please note that the following hormonal imbalances are not limited to morbidly obese individuals—they can be observed in skinny-fat individuals with a normal BMI too.    Hormone #1: Leptin The first hormone is produced by the fat cells called leptin. The function of this hormone is to signal the brain to regulate appetite. Back-story: The food you eat provides glucose to the cells of your body to produce energy. This glucose in your blood is transported to the cells via a mediator called insulin.  Now, in the modern life of abundance, people tend to eat more than what their cells need, so there's always some extra glucose left in the blood. Insulin stores this extra glucose in the liver and muscles. Even after that, if there's still some excess glucose, new storage called adipocytes (fat cells) is created. These adipocytes also have endocrine functions: the production of the leptin hormone.     What is the function of the leptin hormone? The leptin hormone signal the brain to stop sending the hunger signal to the body when there is excess energy in the cells. Nevertheless, having a lot of leptin is not actually a good thing. Your levels of leptin go up indicating that your fat cells are increasing. When your fat cells increase, they take up most of the glucose from the blood; glucose that the body cells need to produce energy. As the body cells are deprived of glucose, the brain gets the signal to increase the hunger cue; resulting in incessant hunger and overeating.  This turns into a condition called leptin resistance. The most common abnormality with people who gain weight but have normal blood glucose is leptin resistance.  The high levels of leptin not only affect the brain but also the beta cells in the pancreas—increasing fat storage, insulin levels, and insulin resistance.  All of this drives up inflammation.    How do you know if you have leptin resistance? You probably have leptin resistance if you: Wake up with no hunger and go hours without the first pang of hunger hitting you in the middle of the day You feel hungry till bedtime, even after eating. You face a lot of difficulties losing weight.    Ways to resolve Leptin Resistance: Intentional Fasting: This fasting cycle intends to shift your metabolism—shifting the use of energy from glucose or carbohydrates to the utilization of fat through a process called ketosis. As this shift happens, your leptin resistance starts to go down. Leptin resistance can be handled by postponing your first meal and preponing your last meal. To practice Intentional Fasting: Stop eating after dinner.  Avoid bedtime snacks.  Have dinner three hours before bedtime.  If you feel the hunger before bed for the first few weeks, drink a little water.  After waking up, break the fast around midday, but check the ketose level before doing that. Caloric Deficit: Leptin resistance happens when you eat more than your body needs, turn it around by a slight caloric deficit. Track your calories, reduce your caloric intake. Do HIIT workouts: Start small and slowly build up the speed and number of reps. Start with ten squats or wall push-ups. Anything that gets your muscles moving and induces sweating. Consistency is the key.  The next hormone is completely in contrast with leptin as it has all the opposite functions.   Hormone #2: Adiponectin  Adiponectin is a protein hormone secreted by the adipose tissue that regulates glucose levels and aids fatty acid breakdown. As the adiponectin levels go up, fat cells go down, as adiponectin stimulates glucose utilization from fat cells for energy expenditure.  One of the early signs of metabolic syndrome is low levels of adiponectin. Metabolic syndrome is a cluster of conditions that involve: Increased Triglycerides Low HDL cholesterol Increased fibroids High abdominal fat (Men: 40-inch in; Women: 35-inch) High fasting blood glucose   What does adiponectin do? Adiponectin helps in: Reducing inflammation Improving insulin sensitivity Increasing the anti-orthogenic, anti-diabetic, and anti-inflammatory properties of the body Reducing the risk of cardiovascular diseases Improving glucose metabolism  Getting the adiponectin high (in double digits) is what doctors look for when resolving metabolic syndrome.    Ways to increase Adiponectin Levels: Adiponectin cannot be injected to increase its levels in the body. However, some simple lifestyle measures can increase the levels of adiponectin in the body. Follow all the afore-mentioned measures for resolving leptin resistance, and long with these: Add aged garlic to your diet: Increases your adiponectin. Eat monounsaturated fats like avocados, nuts, olives, and olive oil. Consume fiber-rich foods daily.    Hormone #3: Cortisol In the modern lifestyle, with the abundance of stress, people experience a chronic alleviation of stress. Cortisol is a hormone produced by the adrenal gland in this chronic state of stress. The hormonal imbalance is the impairment of the hormonal rhythm of cortisol in the body. When we look at the normal rhythm of cortisol—every hormone in our body has a rhythm—it gets high in the morning and goes down as the day goes by and becomes a little lower at night so you get to sleep. This normal rhythm gets disrupted when a person is stressed at all times, and chronic stress is not sustainable.   (insert a graph showing the hormonal rhythm) Study on Cortisol Rhythm A study was conducted among a group of people about psychosocial stressors. These people were divided into two groups: People with a normal Body Mass Index (BMI) People with a high Body Mass Index (BMI) While performing the interventions, the researchers took 4-point measurements of the levels of cortisol: Morning Midday Late afternoon Night The two specific interventions they did to observe the rhythm of the cortisol were: Measuring the participants' cortisol after eating lunch Measuring the participants' cortisol after giving them dexamethasone (external steroids) The reason behind these interventions was to check the response of cortisol levels to stressors like food or external source of cortisol which should suppress your internal production of cortisol so your body doesn't get an excess of cortisol.    Results:  Group A: The rhythm of cortisol in the people from group A was normal—high in the morning, gradually lowering by the day, low at night. After eating lunch, their cortisol levels would peak. Ingesting dexamethasone would suppress the internal production of cortisol in their body.  Group B:  The cortisol rhythm of people in group B was rigid. It did not have the specific ‘S-shaped curve in the cortisol rhythm. Their brain-adrenal connection had become rigid to all the stressors, stimuli, and suppression. When they had lunch, there was barely a peak in the cortisol levels.  There was no response after the ingestion of dexamethasone. Conclusion: The brain-adrenal connection is an indicator of excellent health. The absence of this connection and the rigidity of hormonal rhythm puts you at a high risk of chronic diseases like metabolic syndrome and cardiovascular disease.    What does cortisol do to the body? Cortisol impacts our health by affecting glucose metabolism. Chronic stress, resulting in high, non-responsive, and rigid cortisol has metabolic implications that promote inflammation and disease. High levels of internal cortisol production result in: Increased blood glucose Increased visceral fat accumulation Increased leptin and insulin resistance Decrease in the sex and growth hormones Increased risk of atherosclerosis (hardening of blood vessels) High blood pressure High risk of cardiovascular diseases   Effect of Cortisol on the Memory When your cortisol levels are persistently high and rigid, it damages the hippocampus—the area responsible for information retention and learning. So, what can be done about this rhythmic impairment?  The rise in cortisol levels and the rhythmic impairment of cortisol are due to chronic stress. People feel stressed when they feel helpless about problems that are not under their control—work problems, issues in relationships, financial stressors, etc. Over time, these stressors build our cortisol because we think the same way every day resulting in chronic stress. Cortisol rhythmic impairments should be addressed by managing stress and clearing the mind:  Right after waking up, shut off all external stimuli by closing your eyes. Spend five minutes listening to calming music or sounds around you, and breathe. Focus on your breath. By doing so, you are changing your physiology and bringing your cortisol levels down. Then, no matter how busy your day gets, you will know how to ground yourself. Hopefully, this information has opened your mind to a different way of thinking and different ways of living. Health is intuitive and it's your business.   Look at your habits and shift them little by little. Our goal is to help people understand that disease is not inevitable by giving you knowledge in bite-size portions about the changes you can potentially make, getting to know your body, and reversing disease with everything that's within your power to change. This blog covers the highlights from the latest episode of Chillin with Dr. Chellam on The Three Hormones That Jeopardize Weight Loss by Dr. Nisha Chellam, Board Certified Internist, and Founder of Holistic ICON. You can check out the full video on our YouTube channel by clicking this link: Hoping this blog was helpful. If you have any other questions related to weight loss and hormonal imbalances, please drop us an email with your question and a brief about yourself at drchellam@holisticicon.com or marinas17@holisticicon.com, and we will get back to you shortly   To learn more about adiponectin and other hormones pertinent to your weight loss journey, listen to this  Chillin with Dr. Chellam and check us out on Youtube.  

A new study finds longer daily fasts were demonstrated to produce more favorable improvements in biomarkers that are associated with metabolic and cardiovascular health as well as inflammation. Let's break it down... Support your fasting lifestyle with Berberine HCl & Alpha Lipoic Acid by by MYOXCIENCE Nutrition: https://bit.ly/berberine-biotin-ala-stack Use code Podcast to save Save 40% off this at-home A1C test by Biocoach: http://bit.ly/BOGO-A1C-test Use code HIH10 Links to notes: https://bit.ly/30WjpeE REF: Moro, T., Tinsley, G., Pacelli, et al. (2021). Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors. Medicine and science in sports and exercise, 53(12), 2577–2585. Time Stamps 0:00 Intro 0:18 New Study 0:08 Testing 16 Hour VS 12 Hour Feeding Windows 0:27 Markers of Inflammation decreased 1:17 Only four hour difference in feeding window 2:22 Study Title: 3:43 Testing your metabolic health 4:42 Berberine & metabolic health 5:50 Feeding Window comparisons 6:43 How Calories were distributed 7:36 Whey protein post workout 7:50 TRF group ate less calories by accident 8:33 Strength and muscle loss between two groups 11:08 Testosterone did decrease 11:53 Insulin, Leptin and Adiponectin 12:44 HDL, Triglycerides and glucose 13:52 Chronic Inflammation 15:11 Trade offs to consider

Aging-US published a Special Collection on Eye Disease which included "Involvement of adiponectin in age-related increases in tear production in mice" which reported that the infiltration of lymphocytes into the lacrimal glands occurs with age, and age-related increases in tear production have also been observed in mice. The mechanisms underlying this increase remain unclear, but these authors show that it is not dependent on body weight gain or systemic conditions, such as insulin resistance, using aged mice and high-fat diet-fed mice. Senescence-associated T (SA-T) cells accumulated in the laceral glands of aged mice, particularly females, and they may represent potential targets for treating dry eyes in humans. Dr. Yosuke Shikama from The National Center for Geriatrics and Gerontology said, "Epidemiological studies have shown that the prevalence of dry eye increases every five years after the age of 50 years, with a higher prevalence being reported in women than in men." Age and female sex have been identified as the greatest risk factors for dry eye, and this is supported by clinical findings of decreased tear production in women through the 6th decade of life. Metabolic disorders, such as diabetes, affect tear production and are associated with dry eye. Adiponectin is a 30-kDa multimeric protein that is mainly secreted by white adipose tissue, and has insulin-sensitizing and anti-atherogenic properties. Adiponectin and adipoR2 mRNA expression levels significantly increased in the lacrimal glands of aged mice, but not in those of high-fat diet-fed mice. These results indicate that these molecules are involved in age-related increases in tear production in mice. The Shikama Research Team concluded in their Aging-US Research Output, "the present results demonstrated the accumulation of SA-T cells in aged mice, which occurred to a greater extent in female than in male mice. Furthermore, increased tear secretion in aged mice appeared to be mediated by PPARγ and adiponectin-mediated signaling. These results may explain the discrepancy in the volume of tears secreted with age between humans and mice." Full Text - https://www.aging-us.com/article/102322/text Correspondence to: Yosuke Shikama email: shikama@ncgg.go.jp Keywords: dry eye, adiponectin, peroxisome proliferator-activated receptor gamma, senescence-associated T cells, aging About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways. To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

In this episode, I continue the series covering my first book, Hormonal Nutrition. This episode covers the hormone adiponectin, and goes into what it does in the body, how body fat percentage and fat mass affects it, as well as how it correlates to fat-free mass and fat-loss. I also cover what activities/lifestyle factors, foods, and supplements have an affect on adiponectin levels and adiponectin function.   Get your copy of Hormonal Nutrition here: https://www.amazon.com/Hormonal-Nutrition-Kevin-Russell-Kuhn/dp/1657097463/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1631277287&sr=8-1

Struggling to lose weight after 50? Watch this video to learn the REAL reasons you can't lose weight after 50. Losing weight after menopause requires a more targeted strategy aimed at two things. First, getting rid of old, outdated weight loss beliefs that will never work. Second, learn how to optimize your diet, exercise, sleep, and stress to live a low insulin lifestyle. Learning how to lower insulin resistance after menopause will help you lose menopause belly fat. Often, stress and the associated increase in cortisol, glucose, and insulin is a culprit commonly overlooked by women over 50 trying to lose weight. Sleep deprivation can also cause your hormones to be thrown “out of whack” with an increase in ghrelin, decrease in leptin and human growth hormone. You'll learn why those are important changes that contribute to weight gain in this video. If you're looking for permanent weight loss, learn what to start living a low insulin lifestyle in this episode. To learn more about the DUTCH test I mention in this video, go to https://dutchtest.com/. CoachingIf you're ready to lose the weight for good, you've come to the right place!Join my online course, Weight Loss for Health, to learn the science behind weight loss and habit change so you can lose weight, get healthy, and prevent disease. Also included with the program are weekly office hours with me and a membership site for encouragement, accountability, and support from other members. To learn more, go to https://www.weightlossforhealth.com/join.Free Weight Loss ResourcesWeight Loss Masterclass to Lower Insulin Resistance & InflammationThe 5% Mindset | How to Win at Weight LossThe Ultimate Food Guide | What to Eat to Burn FatConnect on Social>> Subscribe to My YouTube Channel>> Like My Facebook Page>> Follow Me on Instagram>> Connect on LinkedIn>> View My WebsiteSubscribe & Review in Apple PodcastsAre you subscribed to my podcast? If you're not, I want to encourage you to do that today. I don't want you to miss an episode. Click here to subscribe in Apple Podcasts.Now if you're feeling extra loving, I would be really grateful if you left me a review over on Apple Podcasts, too. Those reviews help other people find my podcast and they're also fun for me to go in and read. Just click here to review, select “Ratings and Reviews” and “Write a Review” and let me know what your favorite part of the podcast is. Thank you!

In this episode about insulin resistance in midlife belly fat weight gain I’m going to address the #1 complaint of women in menopause: belly fat. (followed closely by fatigue) Things I’ll cover: Insulin’s role in metabolism and at menopause Insulin’s integrated relationship with other hormones How insulin relates to menopause belly fat Lifestyle factors that change insulin’s effects Effects of exercise in menopause on insulin sensitivity What does insulin do? Insulin helps control blood sugar levels (glucose levels) by signaling the liver and muscle and fat cells to take in glucose from the blood. Insulin therefore helps cells to take in glucose to be used for energy. If the body has sufficient energy, insulin signals the liver to take up glucose and store it as glycogen. When the body doesn’t convert enough glucose, blood sugar levels remain high. Where's the Fat? Women have a different response to midlife weight gain that occurs in response to hormone changes. While men have both subcutaneous and visceral fat deposits, women have more visceral fat storage. Thus, the “menopot” as Dr. Pamela Peeke once coined it. Hence, midlife belly fat weight gain.  Insulin Resistance in Midlife Weight Gain? But I won’t leave you there. Because I’ve shared with you the ACOG 2019 study of over 1 million women showing no correlation between weight gain and menopause. I know if you are one woman who has experience belly fat gain this is no consolation. That’s why we’re here. To understand the role of various hormones in weight gain and belly fat. [Previously I published a podcast and recording for our Flipping 50 membership on cortisol that would also be a good review.] At midlife, a cascade of hormone shifts mean it takes more and more insulin to get glucose into the cells. If you're "doing the same thing and it's not working," you have a clear answer why. Midlife belly fat weight gain is common, not mandatory.  The stabilization of blood sugar occurs through hormones insulin and glucagon. Insulin reduces blood sugar (by helping cells absorb glucose) and glucagon is released (by the liver) when blood sugar levels are too low. Glucagon instructs the liver to release stored glucose, which causes a blood sugar rise. Other Roles of Insulin Insulin also helps healing after injury by delivering amino acids to muscles. As you know it is the amino acids that help build the protein in muscle tissue, so when insulin is low muscles may not heal properly. This cycle of insulin and glucagon support even blood sugar. The balance provides energy to cells while preventing nerve damage that can result from high levels of blood sugars. Insulin inhibits fat burning (lipolysis), even while other circulating hormones are active at the same time stimulating fat burning. Glucagon Epinephrine Norepinephrine Growth hormone Cortisol Also, at the same time insulin stimulates fat storage, other active hormones inhibit it: Leptin, growth hormone, acute increases in cortisol.  It’s not simple. Insulin has an impact on blood sugar and fat storage and fat burning but it’s tempered by many other factors. Insulin itself doesn’t cause weight gain. You need to expend more calories than you eat. (** I typed that incorrectly/inversely the first time.. let's hope I didn't SAY it incorrectly or if I did YOU caught it!) And yet not have too great a deficit and cause stress.  If you have lower insulin spikes after meals, they don’t last as long, and your body is able to burn fat again in a few hours. (That’s why enjoying meals without snacks aids fat burning). Remember though that blood sugar levels can spike if you eat too little, consume artificial sweeteners, and during menopause other hormone changes, will cause a change in the amount of insulin required to get glucose into cells for energy or liver and muscle for storage as glycogen. Menopause symptoms often improve or don’t because of insulin.That includes midlife belly fat weight gain. Because insulin has a cascading effect on other hormones, we’ve got to start by looking at it.  Reversible risk factors for insulin resistance: (lifestyle habits) Diet high in refined carbohydrates Sedentary lifestyle Anxiety and suppressed emotions Sedentary Women If you’re sedentary, intermittent fasting beyond the basics good for everybody can help. Those basics are eat regular meals, avoid snacks and close the kitchen after dinner so you have at least a 12-hour fast overnight. [MORE, is NOT always better though. I see you out there.] Active, Exercising Women If you’re a midlife woman exercising though, you’ll do better fed than fasted. You need a little something to bring up your blood sugar level in the morning and decrease cortisol. Even a little cream in your coffee prior to exercise, a half a banana with a smear of nut butter, or a simple protein shake will work. Then follow with a full high protein low carb meal. Research shows intermittent fasting is more likely to cause impaired glucose intolerance in women, but not men. If you’re an active midlife woman, it’s important to rethink your level and timing of intermittent fasting. If you’re trying but not losing weight, belly fat, and not experiencing more energy, you may want to reconsider your schedule. Take 10 Days to Ditch Exercise Mistakes That Lead to Older, Sicker, Fatter for those that leave you Rested, Recovered, and Recharged.  What Else You Can Do to Support Insulin Levels Check Your Cortisol Levels: If you’re low in the morning and high later, or high then crash, try to avoid over-caffeinating which will drive more cortisol issues. Consider adaptogens like Maca or Ashwaganda. Exercise with moderate amounts of low and high intensity exercise. (unless you’re in adrenal fatigue when you should leave out the HIIT until you’re more restored). Calorie restriction puts increased stress on your body and when you are menopausal it can backfire. It can increase cortisol and insulin, and decrease thyroid function causing you to gain weight. This is especially true if you are restricting calories and exercising more. Remember, “Eat Less and Exercise More”?  Burn it. Tune into your emotions. Somewhere is that girl who used to run around the house with a cape thinking she could do anything. But often we lose the same body confidence and self-esteem we once had. Then try some of the old habits mentioned earlier (undereat, eat and drink foods that don’t serve us, over exercise or do none at all) that make our bodies do the opposite of what we wanted (store fat and drain us of energy). If you’re tolerating things in your life, living angry or in fear, you want to look at how to change that and deal with what you can’t change. Happy people living lives they love have less midlife belly fat weight gain. Have you noticed? (and are not compulsively exercising or rigid in their food and behavior) Other Integrated Hormones: Adiponectin Menopause coincides with an increase in several co-morbidities, which include insulin resistance. The accumulation of the central abdominal fat in women at this time is associated with a decline in the production of a protein called adiponectin. Adiponectin, which is produced by fat, is important for the metabolism of glucose and fatty acids. Let me restate that: a protein produced by fat helps you burn fat. In short, it makes the cells in the body, particularly the muscle and liver cells, more sensitive to the actions of insulin. Low serum adiponectin levels are associated with insulin resistance and the metabolic syndrome, such that the decline in adiponectin with the intra-abdominal weight gain at menopause is believed to play an important role in the development of insulin resistance after menopause Adiponectin and Belly Fat The tendency toward accumulation of abdominal fat – called visceral fat - in women in menopause is associated with a decline in circulating adiponectin. Adiponectin, produced by fat, increases insulin sensitivity by promoting fat oxidation distally in liver and muscle. Low serum adiponectin levels are associated with insulin resistance (IR) and the metabolic syndrome such that the decline in adiponectin with intra-abdominal weight gain at menopause is believed to have an important role in the development of IR after menopause. Many women do, but as many don’t, experience midlife belly fat weight changes. Many women are able to mitigate it. I’ll offer some ways to do that here. The list I’m about to give you is nothing crazy. These are habits you have heard me suggest to you before, things you very likely do already or will realize it’s time to get back to them. Most all of them are good for health for many reasons and adiponectin levels are just one. Ways to Increase Adiponectin Daily intake of oily fish or Omega-3 (I take Nordic Naturals) Monosaturated fats like avocados, nuts, olives, and olive oil Fiber (as if you didn’t need it anyway for toxins, excess estrogen, satiety, regularity and blood sugar) Avoid or Reduce Caffeine –(choose organic coffee to avoid pesticides or matcha to benefit from the ECGC) Get Cold – cryotherapy, sleeping in a really chilled room (66 F) and shivering (embrace that cold climate) Exercise – yoga, weight training and cardio all improved levels of adiponectin How Does Exercise Influence Insulin Sensitivity? Exercise, specifically high intensity exercise, for postmenopausal women restored insulin sensitivity and skeletal muscle insulin-stimulated glucose uptake, as well as muscle mass to the same extent as premenopause women after 3 months of high intensity exercise training. This particular study included strength training, well-documented for support of blood sugar levels, as well as anxiety. I mention because often we high intensity exercise training and assume this is intervals made of burpees. You neither need to do burpees to do high intensity interval training, nor does high intensity exercise always suggest intervals. Muscular fatigue as a gage of intensity for strength training. In another study, published in Menopause, just six weeks of HIIT reduced effects of menopause and age in both perimenopause and postmenopausal women. Previously shared studies of SIT or sprint interval training for women showed an improvement of overall body fat, visceral fat, and an increase of lean muscle tissue. All results that positively influence insulin sensitivity. The Right Exercise & Intensity Evidence exercise positively influences your insulin sensitivity. It reduces the co-morbidities associated with visceral fat weight gain. Other diet and lifestyle factors that support optimal health also improve your insulin sensitivity. Resources: https://www.monash.edu/medicine/sphpm/units/womenshealth/info-4-health-practitioners/insulin-resistance-in-the-menopause https://pubmed.ncbi.nlm.nih.gov/21967160/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832997/ https://pubmed.ncbi.nlm.nih.gov/29338526/ https://pubmed.ncbi.nlm.nih.gov/28953212/ https://pubmed.ncbi.nlm.nih.gov/22089179/ Another Episode You Might Also Like:  Understanding the Role of Cortisol and Exercise in Menopause  

รายการ Dr.Amp Podcast เรื่องเล่าสุขภาพดี กับ หมอแอมป์ โดย นพ. ตนุพล วิรุฬหการุญ รู้ลึกเรื่องฮอร์โมนไขมัน วิธีพิชิตโรคอ้วน กับหมอแอมป์ ปัจจัยสำคัญที่อาจทำให้เราเข้าสู่ภาวะโรคอ้วนได้ มาทำรู้จักกับฮอร์โมนที่เกี่ยวข้องกับไขมันและภาวะโรคอ้วน 1. Leptin (เลปติน) 2. Adiponectin (อดิโพเนคทิน) 3. Resistin (รีซิสทิน) และมารู้จักกับไขมันทั้ง 2 ชนิด Brown Fat (ไขมันดี) และ White Fat (ไขมันเลว) ที่อยู่ในร่างกายเรา

Summary:Even though every human on the planet has stored body fat of differing amounts, it is surprising how little most people actually know about its functions in life. This may be because the science of body fat is relatively new only gaining real interest since the mid-'90s. Fat is so much more than a wobbly store of excess calories, it interacts, communicates, and even supports healthy body processes. Dr Sylvia Tara, the author of The Secret Life of Fat, kickstarts season 3 with a great interview. Guest biography:Sylvia Tara holds a PhD in biochemistry from The University of California, San Diego and an MBA from the Wharton School of the University of Pennsylvania. She was a healthcare management consultant with McKinsey & Company and has worked for the world’s largest biotechnology companies.After an extended battle with her own body fat, Dr Tara became fascinated with its resiliency and embarked on a mission to better understand it. Her book, The Secret Life of Fat, is the culmination of years of research and interviews with physicians, patients and leading scientists.You can learn more about Dr Tara by visiting her personal website.Episode content:This episode is essential listening for anyone who has struggled with their own body fat levels, or for anyone who coaches others to manage their body fat more effectively. Great insights and helpful coaching tips. 1:56 Why listen to this episode4:33 The major roles of body fat in human physiology and health7:07 The recommended level of body fat in males and females to maintain health10:52 The obesity paradox16:30 Different coloured body fat and its purposes19:24 Hormonal factors produced by body fat22:50 A story of how genetic leptin defects interfere with health and hunger27:26 Weight loss and the role of willpower and calories30:44 The impact of obesity on coronavirus pandemic33:04 Suggested strategies for effectively managing body fat levelsRate the show:If you enjoyed this episode, then please rate the show, give a short review, and share it with your friends so they can benefit from this free expert information. Your comments and feedback are always welcome. Please subscribe to the podcast on iTunes or the video series on YouTube so you will receive each update immediately upon release. It also helps the show rank higher and reach more people.For other great episodes and expert guests on the Fit to Succeed show, visit our podcast library at www.nordicfitnesseducation.com

The Gary Null Show is here to inform you on the best news in health, healing, the environment. Intense light may boost heart health A novel use of intense light therapy may help decrease the tissue damage experienced during heart attacks, reveals new research in mice.  University of Colorado, August 19, 2020 The study, out of the University of Colorado and appearing in the journal Cell Reports, shows that exposing lab mice to intense light for a week improved their outcomes after heart attacks. The research also suggests that this procedure could benefit humans, and the researchers outline the reason why. “We already knew that intense light can protect against heart attacks, but now we have found the mechanism behind it,” says the study's senior author Dr. Tobias Eckle, professor of anesthesiology at the University of Colorado School of Medicine in Aurora. Boosting specific gene protects heart In the study, the researchers discovered that intense light influences the functions of the PER2gene, which is expressed by a part of the brain that controls circadian rhythms. By boosting this gene through intense light therapy, the researchers discovered that the mice's heart tissue received extra protection when it experienced issues with oxygen, such as during a heart attack. Additionally, this intense light also heightened cardiac adenosine, which is a specialized chemical that helps with blood flow regulation. In concert, both benefits helped protect heart health. Also, when they studied the mice, the researchers found that being able to physically perceive light was vital, as blind mice experienced no benefits from the intense light. Humans had similar benefits The next step was to see if humans could benefit from light therapy. The researchers worked with healthy human volunteers and exposed them to 30 minutes of intense light. On five consecutive mornings, the researchers exposed the participants to 10,000 lumens of light and drew blood several times. The researchers found that PER2 levels increased in response to light therapy in the human participants as it did in the mice. They also reported that the human volunteers saw a decreased level of plasma triglycerides and improved metabolism.  Dr. Eckle explained that light plays an essential part in human health, not only in regulating the circadian rhythm but in cardiovascular health as well. He adds that according to prior studies, more people throughout the U.S. experience heart attacks during the darker months of winter, even in states that traditionally get more sunshine, such as Hawaii and Arizona.   Study: Supplementation with curcumin offers benefits for patients with metabolic syndrome Coventry University (UK) and Tehran University of Medical Sciences (Iran), August 19, 2020   A study published in the journal Diabetes and Metabolic Syndrome: Clinical Research and Review found that curcumin supplementation can help increase adiponectin levels. Adiponectin is said to help reduce the risk of cardiometabolic disease. According to researchers from the United Kingdom and Iran, people with metabolic syndrome and metabolic disorders can benefit from taking curcumin supplements regularly. Curcumin is the main active component of turmeric, an herb that offers plenty of health benefits. Increased levels of adiponectin through curcumin supplementation Adiponectin is a hormone produced exclusively by adipocytes, or fat cells. It plays a role in insulin response and has anti-inflammatory effects. In fact, low blood levels of adiponectin are linked to cardiovascular diseases, insulin resistance, obesity and dyslipidemia — a condition characterized by abnormal levels of lipids in the blood. In the study, the researchers examined the effect of curcumin on blood adiponectin levels. They reviewed six randomized clinical trials on curcumin, in which 652 participants were included. Data analysis revealed that, compared with a placebo, curcumin supplementation significantly raised adiponectin levels. In trials that lasted longer, the researchers observed greater effects on adiponectin. “We were able to confirm the veracity of a number of independent studies, highlighting that curcumin supplementation, particularly when consumed for less than 10 weeks, may significantly increase adiponectin levels, even when controlling for numerous biological and sociological variables,” wrote the researchers. People with metabolic syndrome, in particular, will find curcumin supplementation useful. Metabolic syndrome refers to a cluster of diseases such as diabetes, hypertension and obesity.      Study finds physical activity is beneficial for health, and more intense activity is better Cambridge University, August 18, 2020 Physical activity of any intensity is beneficial for health, but more intense activity has greater benefits, according to a new study published today in Nature Medicine. In the largest study to date of accelerometer-measured physical activity, a team led by researchers at the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge analyzed data from more than 96,000 UK Biobank participants. Current physical activity guidelines from the UK Chief Medical Officers recommend that adults should aim to be active every day, and also that adults should undertake 150 minutes of moderate intensity activity (equivalent to a brisk walk) or 75 minutes of vigorous intensity activity (such as running) every week. Previous research has shown that moderate and vigorous intensity activity confers greater health benefits than light intensity activity, but it has not been clear if this is because it makes a greater contribution to the total amount of physical activity, or if it has additional health benefits beyond this. A challenge facing researchers has been that the low intensity, incidental movement that accumulates in the course of everyday activities is very hard to recall accurately, and consequently difficult to measure using questionnaires. Wearable devices have enabled better detection of this type of movement that makes up the majority of our daily physical activity, but until now have not been used on a large enough scale to determine if more intense activity makes a contribution to health, distinct from increasing total volume.  The researchers used data from 96,476 middle-aged adults in Great Britain to investigate whether activity of moderate intensity or above contributed to a lower risk of death over and above its contribution to total volume of activity. These individuals wore a research-grade activity tracker on their dominant wrist for a week as part of their participation in the UK Biobank study. The researchers used the data on the duration and intensity of movement collected to calculate the total volume of activity, expressed as physical activity energy expenditure (PAEE). The researchers also determined the percentage of that volume that was achieved through moderate and vigorous intensity activity. The UK Biobank participants had an average PAEE of 40 kJ/kg/day, a third of which was from activity of at least moderate intensity, again on average. Owing to the large scale of the study, there was much variation in the underlying intensity contributions to similar volume levels. The researchers examined if physical activity levels were associated with the risk of death in the follow-up period of on average 3.1 years. During this time 732 of the 96, 476 participants died, though the researchers excluded those who died within the first year from their analysis, and took existing conditions such diabetes, heart disease, and cancer into account as these might reduce physical activity. Expending more energy of any intensity was strongly associated with a lower risk of death over the following three years. Participants who accumulated 20 kJ/kg/day through physical activity were a third less likely to die compared to those who accumulated 15 kJ/kg/day, when the proportion from at least moderate intensity activity was 10% in both cases. The additional activity is the equivalent to a 35-minute stroll, with an extra two minutes at a brisker pace. Those who accumulated 30 kJ/kg/day were about half as likely to die in the follow-up period compared to those who accumulated 15 kJ/kg/day, when the proportion from at least moderate intensity activity was 10% in both cases. However, if this volume of 30 kJ/kg/day included 30% from at least moderate intensity activity, then they were only about a quarter as likely to die. The difference between this scenario and the reference of 15 kJ/kg/day and 10% is equivalent to an hour's stroll plus 35 minutes at a brisker pace. Dr. Tessa Strain of the MRC Epidemiology Unit, and lead author on the paper, said: "Our results show that doing more activity of any intensity is beneficial, but that expending those calories in more intense activity is better still. By gradually building up the intensity of physical activity we do each day we can improve our future health." Dr. Søren Brage, also at the MRC Epidemiology Unit and senior author on the paper, added: "Our research shows how the use of wearable devices capable of measuring physical activity in large cohorts can help disentangle the roles of volume and intensity of activity in influencing future health. The availability of data from nearly 100,000 participants in UK Biobank, backed up by a series of validation studies, allowed us to compare the impact of activity intensity in groups with similar overall volumes of physical activity, and demonstrate that more intense physical activity has health benefits beyond just contributing to total activity volume. Our results also show that activity volumes accumulated almost exclusively through light activity could still halve the mortality risk. Taken together, this means that there are several different pathways to maintain good health and people can choose the path that works best for them."   High blood pressure during pregnancy may mean worse hot flashes during menopause Mayo Clinic, August 19, 2020   Women with a history of high blood pressure disorders during pregnancy are more likely to experience bothersome menopausal symptoms such as hot flashes and night sweats, according to a study published Wednesday, Aug. 19, in Menopause: The Journal of the North American Menopause Society. "We already know that women with high blood pressure during pregnancy or those who experience menopause symptoms such as hot flashes and night sweats have a higher risk of developing heart disease. Our research discovered that women who experienced high blood pressure during pregnancy were much more likely to experience bothersome menopausal symptoms, including hot flashes and night sweats during menopause," says Stephanie Faubion, M.D., the study's lead author. Dr. Faubion is the Penny and Bill George Director for Mayo Clinic's Center for Women's Health. Researchers analyzed the medical records of 2,684 women ages 40 to 65 who were seen for specialty menopause or sexual health consultations at women's health clinics at Mayo Clinic in Rochester, Minnesota, and Mayo Clinic in Scottsdale, Arizona, between May 2015 and September 2019. All study participants completed a questionnaire in which they self-reported their menopause symptoms and effects of these symptoms on their quality of life. Study participants also completed questionnaires that documented whether they experienced high blood pressure disorders during pregnancy, such as preeclampsia or gestational hypertension. Researchers discovered a significant association between women with a history of high blood pressure disorders during pregnancy who reported more bothersome menopausal symptoms. Women with this high blood pressure history using hormone therapy also reported more menopausal symptoms, compared to women with no history of high blood pressure disorders during pregnancy. Dr. Faubion says more research is needed to understand why there is a link between high blood pressure disorders during pregnancy and more severe menopausal symptoms. But one thing is clear: Physicians need to do a better job monitoring women who experience high blood pressuring during pregnancy after they give birth. "We know medical providers have historically done a lousy job identifying and following women with histories of high blood pressure disorders during pregnancy, despite knowing that they have a higher heart disease risk," says Dr. Faubion. "This study is another reminder that these women are different. It is important that they not only receive education with regard to what they may experience during menopause, but also that they undergo routine screenings and counseling on how they can reduce their risk for heart disease."   Oxidative stress a significant contributor to COPD and idiopathic pulmonary fibrosis Justus-Liebig University (Germany), August 17, 2020   According to news reporting originating from Giessen, Germany, research stated, “Healthy ageing of the lung involves structural changes but also numerous cell-intrinsic and cell-extrinsic alterations. Among them are the age-related decline in central cellular quality control mechanisms such as redox and protein homeostasis.” Our news editors obtained a quote from the research from Justus-Liebig-University Giessen, “In this review, we would like to provide a conceptual framework of how impaired stress responses in the ageing lung, as exemplified by dysfunctional redox and protein homeostasis, may contribute to onset and progression of COPD and idiopathic pulmonary fibrosis (IPF). We propose that age-related imbalanced redox and protein homeostasis acts, amongst others (e.g. cellular senescence), as a ‘first hit' that challenges the adaptive stress-response pathways of the cell, increases the level of oxidative stress and renders the lung susceptible to subsequent injury and disease. In both COPD and IPF, additional environmental insults such as smoking, air pollution and/or infections then serve as ‘second hits' which contribute to persistently elevated oxidative stress that overwhelms the already weakened adaptive defence and repair pathways in the elderly towards non-adaptive, irremediable stress thereby promoting development and progression of respiratory diseases.” According to the news editors, the research concluded: “COPD and IPF are thus distinct horns of the same devil, ‘lung ageing.”     Citrus fruits could help prevent obesity-related heart disease, liver disease, diabetes Universidade Estadual Paulista  (Brazil), August 11, 2020    Oranges and other citrus fruits are good for you—they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy. Now a group of researchers reports that these fruits also help prevent harmful effects of obesity in mice fed a Western-style, high-fat diet.   The researchers are presenting their work today at the 252nd National Meeting & Exposition of the American Chemical Society (ACS). ACS, the world's largest scientific society, is holding the meeting here through Thursday. It features more than 9,000 presentations on a wide range of science topics.   "Our results indicate that in the future we can use citrus flavanones, a class of antioxidants, to prevent or delay chronic diseases caused by obesity in humans," says Paula S. Ferreira, a graduate student with the research team.   More than one-third of all adults in the U.S. are obese, according to the U.S. Centers for Disease Control and Prevention. Being obese increases the risk of developing heart disease, liver disease and diabetes, most likely because of oxidative stress and inflammation, Ferreira says. When humans consume a high-fat diet, they accumulate fat in their bodies. Fat cells produce excessive reactive oxygen species, which can damage cells in a process called oxidative stress. The body can usually fight off the molecules with antioxidants. But obese patients have very enlarged fat cells, which can lead to even higher levels of reactive oxygen species that overwhelm the body's ability to counteract them.   Citrus fruits contain large amounts of antioxidants, a class of which are called flavanones. Previous studies linked citrus flavanones to lowering oxidative stress in vitro and in animal models. These researchers wanted to observe the effects of citrus flavanones for the first time on mice with no genetic modifications and that were fed a high-fat diet.   The team, at Universidade Estadual Paulista (UNESP) in Brazil, conducted an experiment with 50 mice, treating them with flavanones found in oranges, limes and lemons. The flavanones they focused on were hesperidin, eriocitrin and eriodictyol. For one month, researchers gave groups either a standard diet, a high-fat diet, a high-fat diet plus hesperidin, a high-fat diet plus eriocitrin or a high-fat diet plus eriodictyol.   The high-fat diet without the flavanones increased the levels of cell-damage markers called thiobarbituric acid reactive substances (TBARS) by 80 percent in the blood and 57 percent in the liver compared to mice on a standard diet. But hesperidin, eriocitrin and eriodictyol decreased the TBARS levels in the liver by 50 percent, 57 percent and 64 percent, respectively, compared with mice fed a high-fat diet but not given flavanones. Eriocitrin and eriodictyol also reduced TBARS levels in the blood by 48 percent and 47 percent, respectively, in these mice. In addition, mice treated with hesperidin and eriodictyol had reduced fat accumulation and damage in the liver.   "Our studies did not show any weight loss due to the citrus flavanones," says Thais B. Cesar, Ph.D., who leads the team. "However, even without helping the mice lose weight, they made them healthier with lower oxidative stress, less liver damage, lower blood lipids and lower blood glucose." Ferreira adds, "This study also suggests that consuming citrus fruits probably could have beneficial effects for people who are not obese, but have diets rich in fats, putting them at risk of developing cardiovascular disease, insulin resistance and abdominal obesity."   Next, the team will explore how best to administer these flavanones, whether in citrus juice, by consuming the fruit or developing a pill with these antioxidants. In addition, the team plans to conduct studies involving humans, Cesar says.     Researchers find link between gut microbiome and cancer treatment outcomes Study highlights positive impact of microbial diversity on immunotherapy response and suggests that cancer patients should eat a high-fiber diet with fruits, vegetables and grains with resistant starches. City of Hope Hospital, August 19, 2020   Physicians at City of Hope, working in collaboration with scientists at Translational Genomics Research Institute (TGen), have found that greater gut microbial diversity in patients with metastatic kidney cancer is associated with better treatment outcomes on Food and Drug Administration-approved immunotherapy regimens. Their findings are outlined in a study published today in the journal European Urology. "We also reported the changes over time in the gut microbiome that occur during the course of therapy -- the cumulative findings from our report open the door to therapies directed at the microbiome," said Sumanta Pal, M.D., one of the study's senior authors and co-director of the Kidney Cancer Program at City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases. The gut microbiome is composed of microbes like bacteria and viruses that reside in the gastrointestinal tract. In recent years, an increase in knowledge about the microbiome in relation to general health has led to deeper explorations of its role in disease states, as well as how the organisms may interact with treatments.  "Previous studies have suggested a relationship between the gut microbiome and response to immunotherapy in solid tumors, including metastatic kidney cancer," said Nicholas Salgia, B.Sc., a clinical research assistant at City of Hope and the paper's lead author. "The results from our study build on earlier findings and reaffirm that the diversity and composition of patients' microbiomes are associated with clinical responses to anti-cancer therapies."  The study, which collected data from 31 people with metastatic kidney cancer, features the first reports of comparing microbiome sequencing at different time points in cancer patients. Participants were asked to provide up to three stool samples: at baseline, four weeks into therapy and 12 weeks into therapy.  Using the clinical trial results, the team was able to identify changes in the microbiome over time in kidney cancer patients receiving immunotherapy. The findings found that a greater variety of organisms was associated with a benefit to the patients, and also suggested that modulating the gut microbiome during the course of treatment may impact responses to therapy.  "The patients with the highest benefit from cancer treatment were those with more microbial diversity, but also those with a higher abundance of a specific bacterium known as Akkermansia muciniphila," said Sarah Highlander, Ph.D., a research professor in TGen's Pathogen and Microbiome Division and one of the study's senior authors. "This organism has been associated with benefit in other immunotherapy studies."  Highlander says one potential takeaway is that oncologists might encourage patients to pay attention to their gut microbiome by eating a high-fiber diet, including fruits and vegetables high in fructo-oligosaccharides such as bananas, dried fruit, onions, leeks, garlic, asparagus and artichokes, as well as grains with resistant starches such as barley or uncooked potato starch, for example. Highlander says that next steps should include expanding the relatively small study to a much larger group of patients that are followed over a longer time period. At City of Hope, researchers have already embarked on a clinical trial to further explore the idea that modulating the microbiome during therapy could have an impact on clinical outcomes.  "We have randomized patients with metastatic kidney cancer to receive a probiotic supplement in addition to an FDA-approved immunotherapy regimen or the immunotherapy alone," explained Salgia. "This work provided a strong framework for such a study."  The collaborations between clinical experts at City of Hope and basic science colleagues at TGen have contributed to advancements in the understanding of not just the microbiome, but also in cancer biology and clinical outcomes at large.  "Our strong relationship with the microbiome team at TGen has fruitfully produced novel insights into the clinical implications of the microbiome in kidney cancer, among other cancer types," said Pal, who is an internationally recognized leader in the area of genitourinary cancers.  Just last month, City of Hope and TGen launched a project to use one of the world's most comprehensive genomic analysis tools to map out personalized treatment plans for metastatic kidney cancer patients. "This current study is a further testament to the collaborative research structure we've developed between the affiliate institutions," said Pal. "Through these collaborations we can implement both a bench-to-bedside and bedside-to-bench research model that will lead to better patient care at City of Hope through access to clinical trials and precision medicine approaches."     Antiapoptotic effects of carotenoids in neurodegeneration University of Alabama, August 17, 2020 According to news reporting out of the University of Alabama research stated, “Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral ischemia, Parkinson's, and Alzheimer's disease.” Our news journalists obtained a quote from the research from University of Alabama: “Apoptosis begins with activation of pro-death proteins Bax and Bak, release of cytochrome c and activation of caspases, loss of membrane integrity of intracellular organelles, and ultimately cell death. Approaches that block apoptotic pathways may prevent or delay neurodegenerative processes. Carotenoids are a group of pigments found in fruits, vegetables, and seaweeds that possess antioxidant properties. Over the last several decades, an increasing number of studies have demonstrated a protective role of carotenoids in neurodegenerative disease. In this review, we describe functions of commonly consumed carotenoids including lycopene, b-carotene, lutein, astaxanthin, and fucoxanthin and their roles in neurodegenerative disease models.” According to the news reporters, the research concluded: “We also discuss the underlying cellular mechanisms of carotenoid-mediated neuroprotection, including their antioxidant properties, role as signaling molecules, and as gene regulators that alleviate apoptosis-associated brain cell death.”

In this episode, Jeff Cyr dives deep into his story. In 1977, Jeff was rushed to the emergency room for back surgery. He ended up getting a diagnosis of severe lumbar spinal stenosis. Jeff had a hard time walking because of his permanent nerve damage. Most of the day, Jeff would sit in his La-Z-Boy. At 330 pounds, Jeff would need to use his cane to get out of the chair. In 2005, Jeff went to the doctor for hernia surgery. After routine blood work, the doctor said his fasting blood sugar was 300, and he had an A1C of 12.0. Officially, Jeff was diagnosed with type 2 diabetes. They gave Jeff a nutritionist who told him to eat a high-carb diet of whole grains and fruits. In 2008, Jeff finally stopped feeling sorry for himself, and he knew something had to change. So, Jeff stopped smoking cold turkey. After a few months, Jeff quit oral morphine cold turkey. Again, a few months later, Jeff started exercising at Planet Fitness. On the first day of exercising, Jeff rode the bike for two minutes. Each day, Jeff would increase the time on his bike. Over the course of sixteen months, Jeff lost 163 pounds. In 2011, Jeff went to the hospital for a liver biopsy. The doctor called Jeff in for some news. He was diagnosed with an auto-immune fatal liver disease called primary sclerosing cholangitis. Basically, it attacks the bile ducts of the liver. What ends up happening is the bile ducts become large and inflamed. Eventually, it will cause cirrhosis of the liver. When that happens, you need a liver transplant. In 2012, Jeff started his low carbohydrate diet. It took eighteen months, and Jeff’s liver enzymes began to ratchet downwards. Eventually, the liver enzymes were almost healthy. Jeff’s doctor didn’t know what to say. Later, we talk about adiponectin – a protein hormone that is extremely important in regard to type 2 diabetes. It’s an anti-inflammatory hormone, and it reduces cardiovascular risks. Here is a shortlist of what adiponectin does in the human body: Increases fatty acid oxidation. Adiponectin is what makes you insulin sensitive. It preserves pancreatic beta cells. Prevents beta cell death. Promotes uptakes of fatty acids. Increases glucose uptake and fat storage. Jeff explains how to protect your adiponectin levels: Lose weight. Omega 3 fish oil. Any form of exercise. Grapeseed extract in high doses. Normal glucose and normal insulin levels. Stay tuned as we talk about the difference between eating fat and producing fat. Plus, Jeff explains why butter and eggs are not the saturated fats that will cause insulin resistance. Lastly, Jeff says he wants people to stop feeling sorry for themselves, and he recommends reading Dr. Bernstein’s Diabetes Solution. Key Takeaways: [ 3:00 ] Jeff Cyr tells his story [ 24:55 ] The contributors to Jeff’s liver disease   [ 29:30 ] All about producing beta cells [ 33:00 ] Educating ourselves about type 2 diabetes   [ 38:15 ] About adiponectin   [ 48:00 ] The drivers for insulin resistance and diabetes   [ 56:10 ] How to protect your adiponectin levels [ 65:30 ] The most important part of adiponectin [ 79:30 ] Eating fat vs. producing and storing fat [ 89:45 ] Jeff’s final advice for people with diabetes  Mentioned in this Episode: Jeff’s Facebook: https://www.facebook.com/jeff.cyr.589 Dr. Bernstein’s Diabetes Solution: http://www.diabetes-book.com Enjoyed the Podcast? Subscribe on iTunes and leave a review! For more Dr. Mowll, check out his  website drmowll.com For Dr. Mowll's high quality nutritional supplements visit https://sweetlifenutritionals.com/ For more information on this week’s episode, visit: Mastering Blood Sugar Podcast

Go to https://drlindseyberkson.com/bigger-belly-fat-smaller-brain-size-shocking-link-mindfulness-15-sophisticated-action-steps/ for an in-depth article on this topic. When it’s fat or real estate, it’s all about location, location, location! Where your fat is located on your body, affects your overall health, your brain structure and function, and even your ability to be mindful… or not.   In this show you learn plenty of facts and fiction about fat cells.   Fat has more functions than we thought. Fat stores excess calories so you can mobilize the fat stores for energy when you need them. Fat releases hormones that control metabolism (metabolism refers to how you burn calories as energy, or store calories as fat). Fat protects organs. Fat acts like Jekyll and Hyde depending on where it lives, what type of fat it is and how many of them are there. Hormone altering chemicals love fat.  Pollutants that mascaraed as hormones, can hide inside fats cells making them act physiologically nasty. Dr. Bruce Blumberg has labeled these endocrine disruptors that especially make for unhealthy fat cells, obesogens. Fat cares about location.   Not all fat is created equal. Where your fat “lives” modifies it’s function. Visceral fat lives inside your gut surrounding your organs. Subcutaneous fat lies under your skin.   Mounting evidence shows that fat lying deep within the abdomen is more perilous than the fat you can pinch with your fingers on your underarm, inner thigh and even on your belly just under your skin. Fat that lives right underneath your skin, that feels relatively soft and that you can pinch between your fingers, is called subcutaneous fat. In a healthy person, you should have a bit of fat under your skin that makes up a bout 90% of your fat stores. The remaining 10% — called visceral or intra-abdominal fat —lies outside of your easy reach, beneath your firm abdominal wall. This fat fills the spaces surrounding abdominal organs like your liver, intestines, spleen and others. Visceral fact can also be found inside your omentum. This is an apron-like flap of tissue that lies under the belly muscles and blankets the intestines. The omentum gets harder and thicker as it fills with fat. As women approach middle years, their proportion of fat to body weight increases often more than this happens in males.  Their belly enlarges. Fat storage starts to thicken the torso, fill up under the armpits, and thicken the waist, especially in the back.     Even if you don't actually gain weight, your waistline can grow by inches as visceral fat pushes out against the abdominal wall.   Fat is biologically active. It releases hormones that affect our health. Subcutaneous fat releases healthy hormones. Subcutaneous fat releases the hormone leptin. When leptin is released in optimal amounts, it acts on the brain to suppress appetite (to help you not over eat) and even helps burn stored fat throughout the body so you don’t get fat. Subcutaneous fat also releases adiponectin. Adiponectin protects the body against diabetes and heart disease by regulating how the body processes fats and sugars. Adiponectin also is a powerful anti-inflammatory molecule, especially protecting the linings of blood vessels. Adiponectin is made a bit by visceral fat, too, as long as there isn’t too much of it. But adiponectin production falls severely as visceral fat volume increases. As people become fatter, they make less adiponectin. This increases their risk of diabetes, heart disease, dementia and the list keeps growing. Visceral fat cells, in comparison, secrete unhealthy molecules and hormones. Visceral produces proteins called cytokines. These can trigger and maintain low-levels of unhealthy inflammation. Excessive inflammation is an independent risk factor for heart disease, type 2 diabetes, dementias and other serious chronic conditions. Visceral fat also produces a precursor to angiotensin, a protein that causes blood vessels to constrict, blood pressure to rise, and increases the risk of stroke. Visceral fat sets the scene for insulin resistance, another risk factor for many diseases as well as symptoms like fatigue, insomnia, out of control hunger and brain fog.     How to tell if you have too much bad visceral fat? If you have a pot belly you most like have excess visceral fat. If you gut protrudes past your breasts. If a woman’s waist is over 35 inches. If a man’s wait is over 40 inches. Your belly/your brain. One study followed 6,500 members of Kaiser Permanente of Northern California, a large HMO (health maintenance organization), for an average of 36 years, from the time they were in their 40s until they were in their 70s. They tracked who got dementia, and compared this to their belly fat. Those with the biggest bellies had the higher risk of dementia compared to people with smaller bellies. The link was true even for people with excess belly fat but overall of normal weight. How does belly fat cause brain damage? Leptin: Excess belly fat can cause leptin malfunction. This can cause issues with cognition, memory and hunger control. RBP4: Researchers at Harvard have discovered that, compared with subcutaneous fat, visceral fat secretes larger amounts of retinol-binding protein 4 (RBP4). Excesses of this molecule increase insulin resistance. As the volume of visceral fat increases, so do levels of RBP4. This connection is so predictable, researchers are developing a blood test for RBP4 as a way for physicians to accurately measure an individual's amount of visceral fat. Belly fat can be confusing. It can be both visceral and subcutaneous. It’s not easy to know exactly how much of your gut fat is killing your brain and your future. At the moment, the only way to determine which of your belly fat is subcutaneous or visceral, is by CT scan. This is expensive. And creates huge radiation exposure .So the test of RBP4  mentioned above, is promising, but not yet available Did you know there are 3 types of fat cells: white, brown and brite (beige). White fat. This is stored energy. When you cut calories, you tend to loose white fat cells. When you add more exercise expenditure to smaller portions, you tend to loose more white fat cells. Most of visceral fat is white fat cells. Brown fat. Brown fat is now thought to be more like muscle than like white fat. When activated, brown fat burns white fat. Brown adipose tissue contributes to your body’s core temperature maintenance through a process called non-shivering thermogenesis. Lean people have more brown fat and more non-shivering thermogenesis. Children have more brown fat than adults and it helps keep them warm. Cold weather promotes brown fat synthesis. Studies show that in Boston in the wintertime, brown fat is more active, and this stimulates metabolism and burning of calories. Brite (beige fat) is brow fat marbled within white fat. Brite fat regulates energy expenditure and fights against obesity. Interchangeable: White fat can turn beige. Beige fat can revert back to white fat. Conversion factors depend upon how you eat, move and the balance of all your hormone family members. For example, underactive thyroid or testosterone can be tamping down your metabolism and play a role into your types of fat cells. Obesity = occurs when you have more white fat than the other types of fat, from consuming more energy than you use, or having unhealthy hormones and nutrient status (hormone depend on nutrients to keep you health). You can fight obesity = by eating less, moving more, and eating more fishmeals or taking essential fatty acid fish supplements. Why? Fish oil helps you make more brown and brite fat, which ups your ability to burn calories. The “Browning of White Fat” (white fat turning beige). Exercise promotes the release of an exercise hormone called Irisin. In 2012, Bruce Spiegelman, PhD, a cell biologist at Dana-Farber Cancer Institute in Boston, dubbed this exercise hormone as "Irisin," after Iris, the Greek messenger goddess. Spiegelman said that exercise “signals” your body to maintain healthier weight. You make the choice to exercise. As you exercise, your activated muscles produce and release irisin. Irisin promotes brown fat cell production within white fat cells. This is browning of white fat, by exercise through the middleman of irisin. More browned white fat means your metabolism increase. You burn more calories. It’s less difficult to maintain a healthier weight. Irisin has multiple benefits. Promotes white fat browning. Triggers neurogenesis (the growth of new neurons), especially within your brain. Increases the expression of BDNF(brain-derived neurotrophic factor). Activates genes involved in learning and memory. Lengthens telomeres (tips of DNA). The longer your telomeres, the more you fight off disease, aging and premature death. In-depth article at Berkson’s Blog:  https://drlindseyberkson.com/bigger-belly-fat-smaller-brain-size-shocking-link-mindfulness-15-sophisticated-action-steps/

Have you ever wondered why it’s simple for some people to lose weight while others struggle? Or how some people can eat all the calories they want and never gain a pound... Well, all of this can be clearly explained through the science of metabolism and what causes some people to “get stuck.” On today’s #CabralConcept 1286 I want to share with you the 8 ways to boost adiponectin (your fat burning hormone) - Enjoy the show! - - -   Show Notes & Resources: http://StephenCabral.com/1286 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)

What is cold thermogenesis and what are its benefits? Let’s talk about the reasons why you should consider doing it. Visit https://www.bodyshotperformance.com/podcasts-blog for the complete show notes of every podcast episode. Topics Discussed in this Episode: What is cold thermogenesis 5 reasons why you should consider doing cold thermogenesis Brown fat activation Improved immune function Improved mood and increased resilience Increased levels of glutathione Reduced levels of uric acid Key Takeaways: Brown fat is a type of fat typically found in the upper back, the shoulders, the sternum, and the collarbones. It’s usually associated with people with a slimmer build and it generates heat by burning the white fat on the stomach, the rump, the hips, and the legs. In other words, it activates the burning of white fat, which is what we normally want to burn. Cold therapy increases the activation of brown adipose tissue by up to 15 times. Cold exposure increases your level of how immune system cells fight disease and infection. Studies show that individuals taking daily cold showers show an increase in white blood cells and shivering increases the body’s metabolic rate. Cold exposure triggers a hormone called adiponectin, burns fat and increases metabolism, but not hunger. The primary function of glutathione is to alleviate oxidative stress and is found in almost every cell of the body. Action Steps: Have a glass of cold water in the morning. Start your day by splashing cold water onto your face, When you take a shower, turn on the tap to cold for the last 30 seconds or less. Just see what you can tolerate. Then graduate to alternating between hot and cold for 30 seconds each. And gradually increase the amount of cold over hot over time and get yourself up to a full-on 5-minute cold shower if you can do it. Leanne said: “A usual method of burning white fat is to exercise or calorie deficit, but we can’t choose the moment we want to start burning fat.” “Adiponectin also increases mitochondrial density, and mitochondria are the powerhouses of our cells, they’re vital for energy production and movement amongst other things. And we need mitochondria in big numbers to help us stay in optimal health.” Thanks for listening! If you’re interested in finding out what your health IQ is, take the Health IQ test to find out, and get a free 39-page report built around our six signals, which are sleep, mental health, energy, body composition, digestion, and fitness. If you’ve enjoyed what you’ve heard on this episode and it’s added value to you, share the episode with someone you think could benefit from it. And don’t forget to leave a rating or a review and subscribe on Apple Podcasts. Links to things mentioned in the show: Oura Ring - use discount code BODYSHOT for €50 off Previous episodes mentioned that you shouldn’t miss: Why we sleep and how to get the sleep you need with Sleep Expert James Wilson The Links Between Sleep and Body Composition: The Secret to Unlocking Weight Loss with Sleep Scientist Dr. Greg Potter More from Leanne Spencer: Bodyshot Performance Bodyshot Performance Limited Facebook page Remove the Guesswork BOOK by Leanne SpencerRise and Shine BOOK by Leanne Spencer   Leanne’s Email

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started! Carla: I have PCOS, and possibly endometriosis & some type of thyroid dysfunction (these two haven't officially been diagnosed, but I have symptoms that have lead me to think I may have them). As I learn more about my condition and how to heal myself through lifestyle & supplements, I also try to get rid of toxins, do detoxes, eat well & exercise. However, I've worked with fire resistant garments for almost 15 years of my life and recently I learned that fire retardants are endocrine disruptors. I'm not able to immediately leave that field of work. Is there a way I can protect myself? I recently started wearing gloves (but they are plastic which is possibly not ideal either) and a cotton mask to keep from breathing in the fibers. What would you recommend? I'm not sure exactly HOW bad it is to continue working like this or if it's something I definitely need to get away from as soon as possible. Thank you for any guidance! Kate: Hi Dr Cabral, I had my gallbladder removed 10 years ago but didn't drastically alter my diet until about 3 years. I eat a mainly paleo lifestyle (with occasional legumes), and I've discovered through recent bloodwork that I have deficiencies in a number of areas. Specifically with Vitamin D and also with my thyroid (I am well outside the "optimal" range but technically still "normal"). I take 3000 IU Vitamin D each day but after researching saw that having no gall bladder can lead to the inability to absorb fat-soluble vitamins as well as possibly affect thyroid and even cholesterol. Is there a way to overcome this? If I were to start taking your daily digestive enzymes, could that help my vitamin absorption? Thank you! Julie: Dear Dr. Stephen Cabral, A friend of mine suggested your podcast last week and I have binged listened ever since. I have dealt with different issues such as Candida and fatigue. I overcame Candida with an elimination diet. Or maybe so I have thought… I have had my thyroid tested and it is normal. All my markers are normal except they found that I have Kidney disease. They were not able to find the root cause of it… My glomerular filtration rate is currently at 46 mL/min. The nephrologist stated that since I am an athletic build that is why. I am currently dealing with mood and fatigue. So if you can point me in the right direction of testing and why, that would be very helpful. Thank you! Julie Johnson  Jill: Hi Dr. Cabral, I have a friend who has achalasia. She has had the balloon dilation procedure done 2-3 times. It often works for a time and then she has difficulty getting food down her esophagus. I'd love to hear your thoughts on diet info related to achalasia, the possibility of overcoming it, and any steps she could take to find health/healing. My understanding is that it's an autoimmune disease ... and can't be "cured" ... ? But I know you overcame Addison's. Any help/direction would be so amazing! Thank you so much for these house calls!!! Claude: Hi! Don't know if you've already talked about this on your podcast: "Elderley's falls" (sarcopenia)?Is there anything i can do for my 93 years old dad?Thank you from Quebec.Canada Elizabeth: Dear Dr. Cabral - I found your podcast about 6-8 months ago after you appeared on EOFire. My daughter was "cured" from her gut, thyroid, chronic EBV through holistic/funcational/naturopathy and it literally gave her a life again! (She lives in Florida and we live in the middle of the country. )So thankful! But today, I'm writing about my husband. Genetically he is challenged. By that I mean that everyone in his family is/was obese. His 2 brothers died in their 50's, (one from a PE and one from untreated diabetes) His two living sisters are in their late-50's and early 60's. One is riddled with fibromyalgia, chronic fatigue and both are overweight. His father died of Lymphoma at 72 and his mother from congestive heart failure at 82. At 40 my husband was diagnosed with prostate cancer, but considered cured from that. At 46, he developed progressive hip pain and the joint was so eroded that he had to undergo a hp replacement at 47. All the nsaids and steroids that he took for that and for years prior to that for a football (knee) injury lead to acute renal failure before the replacement was done. His knee was replaced about a year ago. He has a stressful job and works about 7 days a week. He was also diagnosed with osteopenia at 46 and used Forteo for about 6 months, but I just wasn't comfortable with him continuing that. Since then he has been on Prolea. Uses supplements from the Shalkee Corporation. Daily vitamin, D3, Calcium, Iron and CoQ10. About 2-3 years ago he began gaining weight and becoming more and more fatigued. But our diet had not changed and in fact has gotten cleaner and healthier due to my desire to feel my family whole foods For 25 years he maintained a weight of 165 +/- 3 pounds. He's gained about 35 pounds; mostly around his umbilical area, but also in his groin area. He is tired ALL the time, cold, his eyes are puffy every morning, decreased libido, frequent nose bleeds, (but only after blowing his nose) decreased muscle mass and seems to catch every cold virus that comes around. He's always had periodic bouts of HSV II which seem to be worse with increased stress. He had extensive lab testing done last fall through Veridia Diagnostics. I would be happy to send these to you. Cardiac inflammation is a little high with hs-CRP 2.1 and Homocysteine (10). Food Allergies (IgE) were all negative, but IgA was not done. Lipid; Total Cholesterol 217 Triglycerides 100, HDL 70, LDL 141, Apo B 104. Fasting glucose 97, Insulin 7, A1C 5.3, Cortisol 11.2, Adiponectin 25.6, Leptin 13.9 Ferritin 156, Vitamin D 66, Magnesium 2.2, Creatine 1.3 Cystatin C 1.07 TSH 2.0, T4 5.3, Free T4 1.0, T3 1.23, Free T3 3.0, Thyrodglobuin antibody 10.6, Thyroid peroxidase antibody 12.93, Testosterone 640.6, FTI 31.7, SHBG 70.2, Estadiol 29.6 I think we have a thyroid problem, even though his labs are "normal". What should we do next? Sorry this got so long, but I really value your opinion. He would like to feel more like himself again and lose the weight. I would like to have a more energetic husband. Thank you in advance, Dr. Cabral! Lizzie: Hello! My husband has had a persistent rash on his face that seemed to come out of no where. In January it started. It looks like small tiny pimples and red dots. Forhead, nose, cheeks. Subsides slightly and always comes back. His face is not itchy and it is most prominent when out of shower. Then in Feb his stomach started becoming itcy, more patches of dry skin, not rash-like on his face. He also has had toe-fungus for years, from sports in college. What could be causing this rash and how can he work to get rid of it? He eats very little protein, when he does, crappy chicken. Lots of veggies and he does have a massive sweet tooth. He is 37 yo. he is also going through a job transition. thank you! Terri: I just purchased your digestive enzyme. Do I take this 15 min before each meal or only the first meal of the morning? It then works all day with just taking in the morning? Thank you  Catherine: Hi Stephen, I regularly listen to your podcasts and would love it if you could help me out. Here’s a bit of information about myself, I’m 24, came off the pill just over 2 years ago and got quite bad acne all over my face (got worse and worse over time). Previous to coming off the pill, roughly about 1-2 years before, I became intolerant to dairy. In the past year I have been getting reoccurring yeast infections ("lady regions"). I have just completed a 3 month parasite cleanse, saw lots come out in my poop and I feel much better for doing it. However I am still getting yeast infections, I have figured out I have candida / gut issues. Would you recommend any other tests apart from the acids test? I’m not sure if my hormones could still be imbalanced? I have cut out a lot of foods that I used to eat such as bread, refined sugar etc but it’s not enough to kill whatever yeast/bacteria is inside me. Thank you Annie:  Hello, I have been suffering with halitosis for around 15 years. I have been to every specialist that there is. I have even had my stomach biopsy and I have been to several dentist and gum specialist to rule out oral health care and everyone tells me I am fine and they cannot find anything wrong. My breath smells like feces and I didn't know what else to do? Please tell me where to start. Do you except health insurance? Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Specific Show Notes & Resources: http://StephenCabral.com/884 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)

When it’s fat or real estate, it’s all about location, location, location! Where your fat is located on your body, affects your overall health, your brain structure and function, and even your ability to be mindful… or not. In this show you learn plenty of facts and fiction about fat cells. Fat has more functions than we thought. Fat stores excess calories so you can mobilize the fat stores for energy when you need them. Fat releases hormones that control metabolism (metabolism refers to how you burn calories as energy, or store calories as fat). Fat protects organs. Fat acts like Jekyll and Hyde depending on where it lives, what type of fat it is and how many of them are there. Hormone altering chemicals love fat.  Pollutants that mascaraed as hormones, can hide inside fats cells making them act physiologically nasty. Dr. Bruce Blumberg has labeled these endocrine disruptors that especially make for unhealthy fat cells, obesogens. Fat cares about location. Not all fat is created equal. Where your fat “lives” modifies it’s function. Visceral fat lives inside your gut surrounding your organs. Subcutaneous fat lies under your skin. Mounting evidence shows that fat lying deep within the abdomen is more perilous than the fat you can pinch with your fingers on your underarm, inner thigh and even on your belly just under your skin. Fat that lives right underneath your skin, that feels relatively soft and that you can pinch between your fingers, is called subcutaneous fat. In a healthy person, you should have a bit of fat under your skin that makes up a bout 90% of your fat stores. The remaining 10% — called visceral or intra-abdominal fat —lies outside of your easy reach, beneath your firm abdominal wall. This fat fills the spaces surrounding abdominal organs like your liver, intestines, spleen and others. Visceral fact can also be found inside your omentum. This is an apron-like flap of tissue that lies under the belly muscles and blankets the intestines. The omentum gets harder and thicker as it fills with fat. As women approach middle years, their proportion of fat to body weight increases often more than this happens in males.  Their belly enlarges. Fat storage starts to thicken the torso, fill up under the armpits, and thicken the waist, especially in the back.   Even if you don't actually gain weight, your waistline can grow by inches as visceral fat pushes out against the abdominal wall. Fat is biologically active. It releases hormones that affect our health. Subcutaneous fat releases healthy hormones. Subcutaneous fat releases the hormone leptin. When leptin is released in optimal amounts, it acts on the brain to suppress appetite (to help you not over eat) and even helps burn stored fat throughout the body so you don’t get fat. Subcutaneous fat also releases adiponectin. Adiponectin protects the body against diabetes and heart disease by regulating how the body processes fats and sugars. Adiponectin also is a powerful anti-inflammatory molecule, especially protecting the linings of blood vessels. Adiponectin is made a bit by visceral fat, too, as long as there isn’t too much of it. But adiponectin production falls severely as visceral fat volume increases. As people become fatter, they make less adiponectin. This increases their risk of diabetes, heart disease, dementia and the list keeps growing. Visceral fat cells, in comparison, secrete unhealthy molecules and hormones. Visceral produces proteins called cytokines. These can trigger and maintain low-levels of unhealthy inflammation. Excessive inflammation is an independent risk factor for heart disease, type 2 diabetes, dementias and other serious chronic conditions. Visceral fat also produces a precursor to angiotensin, a protein that causes blood vessels to constrict, blood pressure to rise, and increases the risk of stroke. Visceral fat sets the scene for insulin resistance, another risk factor for many diseases as well as symptoms like fatigue, insomnia, out of control hunger and brain fog. How to tell if you have too much bad visceral fat? If you have a pot belly you most like have excess visceral fat. If you gut protrudes past your breasts. If a woman’s waist is over 35 inches. If a man’s waist is over 40 inches. Your belly/your brain. One study followed 6,500 members of Kaiser Permanente of Northern California, a large HMO (health maintenance organization), for an average of 36 years, from the time they were in their 40s until they were in their 70s. They tracked who got dementia, and compared this to their belly fat. Those with the biggest bellies had the higher risk of dementia compared to people with smaller bellies. The link was true even for people with excess belly fat but overall of normal weight. How does belly fat cause brain damage? Leptin: Excess belly fat can cause leptin malfunction. This can cause issues with cognition, memory and hunger control. RBP4: Researchers at Harvard have discovered that, compared with subcutaneous fat, visceral fat secretes larger amounts of retinol-binding protein 4 (RBP4). Excesses of this molecule increase insulin resistance. As the volume of visceral fat increases, so do levels of RBP4. This connection is so predictable, researchers are developing a blood test for RBP4 as a way for physicians to accurately measure an individual's amount of visceral fat. Belly fat can be confusing. It can be both visceral and subcutaneous. It’s not easy to know exactly how much of your gut fat is killing your brain and your future. At the moment, the only way to determine which of your belly fat is subcutaneous or visceral, is by CT scan. This is expensive. And creates huge radiation exposure .So the test of RBP4  mentioned above, is promising, but not yet available Did you know there are 3 types of fat cells: white, brown and brite (beige). White fat. This is stored energy. When you cut calories, you tend to loose white fat cells. When you add more exercise expenditure to smaller portions, you tend to loose more white fat cells. Most of visceral fat is white fat cells. Brown fat. Brown fat is now thought to be more like muscle than like white fat. When activated, brown fat burns white fat. Brown adipose tissue contributes to your body’s core temperature maintenance through a process called non-shivering thermogenesis. Lean people have more brown fat and more non-shivering thermogenesis. Children have more brown fat than adults and it helps keep them warm. Cold weather promotes brown fat synthesis. Studies show that in Boston in the wintertime, brown fat is more active, and this stimulates metabolism and burning of calories. Brite (beige fat) is brow fat marbled within white fat. Brite fat regulates energy expenditure and fights against obesity. Interchangeable: White fat can turn beige. Beige fat can revert back to white fat. Conversion factors depend upon how you eat, move and the balance of all your hormone family members. For example, underactive thyroid or testosterone can be tamping down your metabolism and play a role into your types of fat cells. Obesity = occurs when you have more white fat than the other types of fat, from consuming more energy than you use, or having unhealthy hormones and nutrient status (hormone depend on nutrients to keep you health). You can fight obesity = by eating less, moving more, and eating more fishmeals or taking essential fatty acid fish supplements. Why? Fish oil helps you make more brown and brite fat, which ups your ability to burn calories. The “Browning of White Fat” (white fat turning beige). Exercise promotes the release of an exercise hormone called Irisin. In 2012, Bruce Spiegelman, PhD, a cell biologist at Dana-Farber Cancer Institute in Boston, dubbed this exercise hormone as "Irisin," after Iris, the Greek messenger goddess. Spiegelman said that exercise “signals” your body to maintain healthier weight. You make the choice to exercise. As you exercise, your activated muscles produce and release irisin. Irisin promotes brown fat cell production within white fat cells. This is browning of white fat, by exercise through the middleman of irisin. More browned white fat means your metabolism increase. You burn more calories. It’s less difficult to maintain a healthier weight. Irisin has multiple benefits. Promotes white fat browning. Triggers neurogenesis (the growth of new neurons), especially within your brain. Increases the expression of BDNF(brain-derived neurotrophic factor). Activates genes involved in learning and memory. Lengthens telomeres (tips of DNA). The longer your telomeres, the more you fight off disease, aging and premature death. In-depth article at Berkson’s Blog: https://drlindseyberkson.com/bigger-belly-fat-smaller-brain-size-shocking-link-mindfulness-15-sophisticated-action-steps/ 

We all know about hormones and how much they affect us. This segment is ALL about how they affect one specific area of our health: weight loss. You'll learn the top most critical hormones when it comes to weight loss, what creates imbalance, and some simple steps you can take to ensure they're working for you—rather than against you! Next, we have my very special guest Sarah Ribner who is an entrepreneur and co-founder of Piper Wai. Sarah's success story on Shark Tank has been seen on Forbes, Shape, QVC, HSN, Self Magazine. Listen in as Sarah shares what inspired her to get into the field of Natural Deodorants and what we should be aware of as consumers when it comes to taking care of our health and overall wellbeing. [BULLETS] Tony shares what hormones are and what they actually do in our body's... How fiber-rich, nutrient-dense, plant-based and Beauty Detox diet help with hormones across the board... We break down what leptins, ghrelins, adiponectin, cortisol, and insulin are and how they affect the body... Ways to affect hormones positively...   Sarah shares what inspired her to want to get into the field of Natural Deodorants and how she got started... We discuss why it is important to balance the PH of the underarm...   Why Underarm Cleanses are gaining popularity and how we feel about them... What Activated Charcoal is and how it has the power to bind to and eliminate poisons from the body... We discuss how PiperWai has been able to navigate the waters of going up against big pharmaceuticals in this 18 Billion dollar industry when conventional deodorants have such harmful chemicals in them... How to overcome the biggest complaints about natural deodorants and how to overcome these pitfalls...     [FEATURED GUESTS] About Sarah Ribner It all started when Jess Edelstein decided she'd had enough of the struggle with harsh, chemical ingredients in typical deodorants that irritated her sensitive skin. There had to be better way to stay dry and odor free. So she set out to invent her own formula from completely natural ingredients that aren't "powder fresh" and wouldn't burn or rash. She found the answer in her own kitchen mixer, using activated charcoal, essential oils, and natural moisturizers. To test it out, she shared it with her best friend Sarah Ribner who took it on a trip to South America. It held up trekking through the hot and humid weather, and by the end of her trip, Sarah was a believer. The co-founders, Sarah and Jess (both finalist in Forbes 30 under 30), first became business partners in elementary school at their lemonade stand. Since airing on ABC's Shark Tank they are making headway into the health and wellness field and have been seen on FORBES, Shape, QVC, HSN, Inc, Self, and many other outlets. About Anthony Flores, or "T" as Kimberly affectionately refers to him: He is a long-time friend of hers who, after graduating from Stanford University, began researching and writing professionally in the health space full-time. He has a passion for natural health, especially Beauty Detox, and loves to share exciting new studies and insights he learns with Kimberly and the community! He can be found writing spiritual/inspirational words on Instagram @poetrybyanthony. [RESOURCES / INFORMATION] Leptin:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430504/   Adiponectin: https://www.ncbi.nlm.nih.gov/pubmed/20814416 Ghrelin:  https://www.precisionnutrition.com/leptin-ghrelin-weight-loss Cortisol:  https://www.ncbi.nlm.nih.gov/pubmed/16353426 Insulin: https://idmprogram.com/insulin-causes-weight-gain-hormonal-obesity-iv/ 5 Sneaky Hormones that Could be Sabotaging Your Weight Loss!:https://kimberlysnyder.com/blog/2015/01/28/5-sneaky-hormones-that-could-be-sabotaging-your-weight-loss/ 3 Ways To Treat THIS Invisible Cause Of Weight Gain!:https://kimberlysnyder.com/blog/2017/01/25/3-ways-to-treat-this-invisible-cause-of-weight-gain/...

In unserer aktuellen Podcastfolge geht es um das Thema Koffein. Ist es wirklich so ungesund und macht es uns kaputt oder ist es doch ungefährlich? Dieser Frage und dem Nutzen von Koffein gehen wir auf den Grund. Quellen: Bhaktha, G., Nayak, B. S., Mayya, S. & Shantaram, M., 2015. Relationship of Caffeine with Adiponectin and Blood Sugar Levels in Subjects with and without Diabetes. Journal of Clinical and Diagnostic Research, January, 9(1), pp. BC01-BC03. Daly, J. W., Holmen, J. & Fredholm, B. B., 1998. Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine.. Lakartidningen, 16 December, 95(51-52), pp. 5878-83. Ding, M. et al., 2014. Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis. Diabetes Care, February, 37(2), pp. 569-586. Floegel, A. et al., 2012. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study.. American Journal of Clinical Nutrition, April, 95(4), pp. 901-8. Hogervorst, E. et al., 2008. Caffeine improves physical and cognitive performance during exhaustive exercise.. Medicine and Science in Sports and Exercise, October, 40(10), pp. 1841-51. Imatoh, T. et al., 2011. Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males. European Journal of Nutrition, June, 50(4), pp. 279-84. Kempf, K. et al., 2010. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial.. American Journal of Clinical Nutrition, April, 91(4), pp. 950-7. Li, S., Shin, H. J., Ding, E. L. & van Dam, R. M., 2009. Adiponectin Levels and Risk of Type 2 Diabetes - A Systematic Review and Meta-analysis. JAMA, 8 July, 302(2), pp. 179-188. Nurminen, M. L., Nittynen, L., Korpela, R. & Vapaatalo, H., 1999. Coffee, caffeine and blood pressure: a critical review.. European Journal of Clinical Nutrition, November, 53(11), pp. 831-9. Satel, S., 2006. Is caffeine addictive? - a review of the literature.. American Journal of Drug and Alcohol Abuse, 32(4), pp. 493-502.

Tara Thorne is a clinical nutritionist living in Canada & in this episode she is going to talk about functional medicine approach to weight loss. We'll also talk about intermittent fasting and supplements. Here's what you'll hear:  Min 02:30 Introduction to Tara Thorne Min 04:00 Health effects of extra fat tissue Min 07:00 Loving your body Min 07:55 Mindset for health Min 09:25 Adiponectin Hormone Min 12:30 Stress, cortisol, insulin & weight connection Min 16:35 Why cortisol increases with age Min 19:20 Gut health & weight management Min 24:40 Nutrition for weight loss Min 28:30 Protein and weight loss Min 31:00 Intermittent fasting Min 36:40 Supplements for weight loss, sugar cravings & boosting Adiponectin Min 45:15 Tara's coaching program & resources   To learn more about Tara Thorne, visit her website here and follow her on social media: Facebook Instagram Pinterest   Tara Thorne's Resources:  Consultations   Sign Up For Our Newsletter  If you have not yet joined our community, be sure to grab our hidden Hormone stressors quiz here, and come on board! Restore Your Radiance Program Click here to learn about our Restore Your Radiance Program.    Thanks for listening, Bridgit Danner, Founder of Women's Wellness Collaborative

Ep. 226: The Perfect Plate? In this episode, Stacy and Sarah discuss whether different foods should never be eaten together. Click the picture above to be taken to iTunes   If you enjoy the show, please review it in iTunes! The Paleo View (TPV), Episode 226: The Perfect Plate? Intro (0:00) News and Views (0:40) Stacy is feeling better, but Sarah is catching up from taking care of a sick kid! Sarah now has a real Christmas tree, following in Stacy's footsteps. Stacy and Matt have a tradition of cutting their own tree with the boys, now 11 years strong! Sarah's philosophy is "Do what feels good to you, with guidance from scientific research," words we can all live by! This week's topic: Food combining! (10:04) A 14 year old girl has asked this question about food combining, an idea from other alternative diet communities about not eating some food with other foods. We had Mira and Jayson Calton on our show, and they have ideas about food combining as well. In particular, Stacy remembers Mira talking about spinach being high in oxalic acid, and therefore counteracting all the nutrients in the meal you are eating. Oxalates and Phytates are antinutrients that bind to other nutrients, rendering them unable to be processed in the body. A healthy gut microbiome can liberate those nutrients later. But it's only the acid that is able to bind to minerals. Usually in foods these compounds are already bound up, and therefore unable to bind to nutrients in other components of your meal. Our question is about ideas like only eating eating fruit by itself and building a "proper plate". Caroline (14 years old) asks, "What do you think about properly combined meals? Meaning no more than one concentrated food per meal which is anything other than fruit or vegetable. And only eating fruit on an empty stomach, raw? And what about about egg yolks. Said that eggs should only be eaten raw... And that scrambling was the worst way to have them; that would damage their cholesterol?" (17:21) We encourage people to look at the source of information, including us! Examine where they're getting their ideas and why because anyone can type anything on the internet. There are a lot of signaling hormones in the digestive system that lead you to believe that meals are best with a variety of foods: Digestion is a process of breaking food down into smaller and smaller pieces until you get to small molecules the body can use. It starts in the mouth with chewing, which is mechanical digestion, and saliva, which has enzymes like salivary amylase to begin the chemical digestion Food then goes to the stomach where stomach acid and enzymes that break down protein The small intestine receives this chyme, which activates signals to various organs to do their work, like the pancreas and gall bladder. The small intestine has three parts: Duodenum, Jejunum, and Ileum The large intestine has most of the gut bacteria and is where fermentation happens. Everything that is unable to be digested forms stool Hunger hormones are released all along the way. Adiponectin lets the brain know how much energy stores there are, as does leptin and insulin Cholecystokinin increases when we eat fats. It's the fastest hormone that tells the brain to stop eating. This is why eating fat helps with satiety. It also slows digestion to give enzymes time to work. It signals for release enzymes to be released that break down all macronutrients. And because its a problem when protein enzymes have no protein to break down, it seems like pairing fat and protein is a great idea. Oxyntomodulin supresses hunger when eating in the presence of protein and carbohydrates and slows digestions Peptide YY signals to the pancreas to stop producing enzymes and reduces hunger while helping the colon to absorb water and electrolytes. Glucagon-like Peptide 1 tells the brain to stop eating in response to fat, protein and carbohydrates from the last part of the intestine. Ghrelin is the most famous hunger hormone. When it is high, it signals the body to eat. It is secreted by the stomach when it is empty. It is kind of the opposite of leptin. Glucose, protein and fiber have the biggest signalling effect on ghrelin. For more on hunger hormones, see Sarah's post here. Because these all work in tandem, it seems that a diverse and balanced meal is the best way to go. There is no special "fruit-only" system at all. And often some detrimental effects are found to disappear when other foods are also consumed. Like the link between red meat and cancer. See Sarah's post on this here. Liz Wolfe talked about synergystically using food to be nutrient sufficient. Some vitamins need fat to be absorbed so your fat free salad dressing isn't helping. Because of Stacy's lack of gallbladder, she gets indications that eating some single foods alone don't work for her. Especially for breakfast. The other part of the question is about cooking food. Does cooking destroy things? Microwaves don't break down nutrients any more than other cooking methods do. See Sarah's post on microwaves. While some nutrients are degraded by cooking, other nutrients are formed. Plus, cooking begins digestion and is helpful to you. Humans started using fire about 1.5 million years ago and by 800,000 years ago, most food was being cooked. Evolutionary biologists tend to believe that cooking was the important adaptation that allowed us to become modern humans because it gave us extra energy stores to grow big brains and improve tool use. Cooking unravels proteins so the digestion doesn't have to. This is very useful for the body and allows more nutrient absorption. The only thing the body can't reform is Vitamin C, but cooking only breaks down about 10% of the Vitamin C Protein is best cooked most of the time. Fat does break down at very high heat, and only when isolated, i.e. cooking flax oil will oxidize it. Cooking flax seeds won't oxidize at the same heat.) Browning on meat isn't carcinogens, but char is carcinogenic. But eating vegetables will usually eliminate the carcinogenic effect. Eating a lot of vegetables helps to make sure the carcinogens are eliminated and your immune system working to take out cancer cells. Make sure you get Vitamin D, get enough sleep, reduce stress, and eat veggies to stay health. Have we mentioned how much Sarah is into vegetables? Science now saying that perhaps we should be eating up to 8 servings of vegetables a day. Fiber is the best, by the way, and it's also high in veggies. It's especially important for keeping your gut microbiome healthy. Be mindful to put things back into your diet to take care of the nutrients you are eliminating from your diet. There are a lot of pseudoscience whackadoos out there that will sell you something for their own gain, not because they actually think their odd ideas will help you. Be careful out there! Outro (58:07)     Support us by shopping through links on our sidebars, please!

If you are restricting calories orlimiting your diet but not seeing results, hormones may be to blame! Hormonescan impact your ability to use calories, balance blood sugar, boost metabolism,burn belly fat, and gain satisfaction from foods. In this episode, Ali Millerwill share 5 hormones that may be making you fat and share a recipe that canhelp get things on track! Hormones covered in this episode include Leptin(plays a role with satiety or feeling of satisfaction), Estrogen (a sexhormonethat pays a role in belly fat but also in emotions and supple skin) Cortisol(primary stress hormone released during fight-or-flight), Adiponectin (made inthe body’s fat stores and plays a role with how efficient the body is atmetabolizing calories) and Dopamine (a neurohormone that plays a role in rewardseeking or cravings). Learn more about all 5, which foods can increase ordecrease their production, and more!   Also covered in thisepisode: ●     A recipe that address all 5hormones with Food-As-Medicine ●     What labs you may want torun to assess hormones ●     Important Vitamins,Minerals, and Supplements to consider ●     The relationship betweenfat and hormones 

Endotheliale Vorläuferzellen bei Patienten mit Diabetes mellitus sind dysfunktional. Bisher fehlen jedoch wirkungsvolle Therapien, um diese Funktionsstörung zu rekonstituieren. Da Adiponectin positive Effekte auf die Endothelfunktion hat, wurden in der vorliegenden Arbeit die funktionellen Auswirkungen einer Behandlung von endothelialen koloniebildenden Zellen (endothelial colony-forming cells; ECFC) mit globulärem Adiponectin (gAcrp), der aktiven Domäne des Adiponectins, untersucht. ECFC wurden aus Peripherblut von Patienten mit Diabetes mellitus Typ 2 (dmECFC) isoliert und mit ECFC von jungen, gesunden Probanden (yECFC) sowie gleichaltrigen Probanden ohne Diabetes mellitus (hECFC) verglichen. Die Zellen wurden über 48 Stunden mit gAcrp behandelt und anschließend hinsichtlich Zellzahl, Zellzyklus und Migrationsfähigkeit untersucht. Zur Evaluation in vivo wurden menschliche ECFC in normoglykämische, athyme NMRI nu/nu Mäuse, sowie in Mäuse mit Streptozotocin-induzierter Hyperglykämie injiziert, die zuvor einer einseitigen Hinterlaufischämieoperation unterzogen wurden. Während dmECFC im Vergleich zu yECFC und hECFC eine funktionelle Beeinträchtigung zeigten, verbesserte gAcrp deren Proliferation und Migration signifikant. Diese Effekte waren allerdings bei hECFC ausgeprägter als bei dmECFC und sind über den Cyclooxygenase-2- Weg vermittelt. Besonders hervorzuheben ist jedoch, dass eine deutliche und anhaltende Verbesserung der in vivo-Neovaskularisation im Vergleich zu unbehandelten dmECFC beobachtet werden konnte, wenn die Tiere mit gAcrp-vorbehandelten Zellen behandelt wurden. Dieser Behandlungserfolg stellte sich sowohl unter normoglykämischen, als auch unter hyperglykämischen Bedingungen ein. Zusammenfassend konnte gezeigt werden, dass eine Vorbehandlung von ECFC mit gAcrp deren Funktionalität in vitro und in vivo unter normoglykämischen, wie auch unter hyperglykämischen Bedingungen verbessert. Eine Zelloptimierung mittels gAcrp vor Zelltherapie könnte also ein neuartiger Ansatz sein, um der funktionellen Beeinträchtigung von ECFC bei Diabetikern zu begegnen.

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5 x 10(-8)-1.2 x 10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p

The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms ( SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P

Atherosclerosis is the primary cause of coronary artery disease (CAD). There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary syndrome (ACS). The impact of adiponectin on lesion composition still remains to be determined. We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified. In bivariate analysis adiponectin levels were inversely correlated with total coronary plaque burden (r = -0.21, p = 0.0004), mixed (r = -0.20, p = 0.0007) and non-calcified plaques (r = -0.18, p = 0.003). No correlation was seen with calcified plaques (r = -0.05, p = 0.39). In a fully adjusted multivariate model adiponectin levels remained predictive of total plaque burden (estimate: -0.036, 95%CI: -0.052 to -0.020, p

Introduction Inflammatory stimuli are causative for insulin resistance in obesity as well as in acute inflammatory reactions. Ongoing research has identified a variety of secreted proteins that are released from immune cells and adipocytes as mediators of insulin resistance; however, knowledge about their relevance for acute inflammatory insulin resistance remains limited. In this study we aimed for a clarification of the relevance of different insulin resistance mediating factors in an acute inflammatory situation. Methods Insulin resistance was measured in a cohort of 37 nondiabetic patients undergoing cardiac surgery by assessment of insulin requirement to maintain euglycaemia and repeated measurements of an insulin glycaemic index. The kinetics of cortisol, interleukin 6 (IL6), tumour necrosis factor alpha (TNF alpha), resistin, leptin and adiponectin were assessed by repeated measurements in a period of 48 h. Results Insulin resistance increased during the observation period and peaked 22 h after the beginning of the operation. IL6 and TNF alpha displayed an early increase with peak concentrations at the 4-h time point. Serum levels of cortisol, resistin and leptin increased more slowly and peaked at the 22-h time point, while adiponectin declined, reaching a base at the 22-h time point. Model assessment identified cortisol as the best predictor of insulin resistance, followed by IL6, leptin and adiponectin. No additional information was gained by modelling for TNF alpha, resistin, catecholamine infusion rate, sex, age, body mass index (BMI), operation time or medication. Conclusions Serum cortisol levels are the best predictor for inflammatory insulin resistance followed by IL6, leptin and adiponectin. TNF alpha, and resistin have minor relevance as predictors of stress dependent insulin resistance.

Background: Adiponectin acts as an antidiabetic, antiinflammatory and antiatherogenic adipokine. These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR1 and AdipoR2. Aim: The purpose of this study was to determine whether variations in the AdipoR1 and AdipoR2 genes may contribute to insulin resistance, dyslipidemia and inflammation. Methods: We sequenced all seven coding exons of both genes in 20 unrelated German subjects with metabolic syndrome and tested genetic variants for association with glucose, lipid and inflammatory parameters. Results: We identified three AdipoR2 variants (+795G/ A, +870C/A and +963C/T) in perfect linkage disequilibrium (r(2) = 1) with a minor allele frequency of 0.125. This haplotype was associated with higher plasma adiponectin levels and decreased fasting triglyceride, VLDL-triglyceride and VLDL-cholesterol levels. No association, however, was observed between the AdipoR2 SNP cluster and glucose metabolism. Conclusion: To our knowledge, this is the first study to identify an association between genetic variants of the adiponectin receptor genes and plasma adiponectin levels. Furthermore, our data suggest that AdipoR2 may play an important role in triglyceride/VLDL metabolism.

*This show covers an incredibly rich and informative article on* *DrJackKruse.com* ( https://jackkruse.com/ ) *dealing with how our circadian clock affects our hormone function and all aspects of our biology. We’ll travel around the 24-hour clock and enjoy 21 different insights about hormone and metabolic function from extreme biohacker and anti-aging expert Dr. Jack Kruse.* This guy is WAY out there at the extreme edge of health and that’s what makes him someone worth checking into. I understand that he has his critics and second guessers, but he is clearly highly advanced in his thinking, scientific research and life experience as a neurosurgeon. In this episode, he shares how his life turned in 2007 when he injured his knee surgery at 357 lbs and decided to get healthy. He started studying like crazy, reading through thousands of research articles, and landed in the area that claimed, “Obesity is not the result of too many calories, not enough exercise or living a slothful existence. Obesity begins in the eye because of an altered spectrum of light.” No one understands how *artificial light is the driving force behind modern neolithic diseases tied to mitochondrial dysfunction.* That is Dr. Kruse’s sole focus now: he aims to teach people the world of quantum biology. Dr. Kruse lost 133 pounds in one year and started curing patients at his Nashville clinic to eventually develop his “Leptin Rx Reset,” *a protocol that acts as a brain surgery without ever using a blade* , completely *rewiring the hypothalamus* by aligning with our natural circadian rhythms and mastering the “timing” of our evolutionary blueprint. His findings include: * The timing of when you eat is more important than what you eat: seeing sunlight in the morning is critical, * Snacking or eating “small meals” every 2-3 hours as commonly advocated by conventional medicine all but guarantees life-long obesity. * Anyone can lose massive amounts of weight without ever counting a calorie. * Rigorous cardio exercises (like long distance running or chronic cardio routines) leads to stem cell reduction and shaves years off the end of your life. * Eating fats, which conventional medicine told us to shun, is ideal for Optimal Health. We will have to work through a ton of scientific terms and concepts, but my goal is to do my best to distill the message into *simple and actionable takeaways that can improve your health* as I go through 21 separate insights from this comprehensive article published at Dr. Jack Kruse’s longevity-focused website ( https://jackkruse.com/cold-thermogenesis-7/ ) , taking you through a 24-hour day. *First, ask yourself: How does your day begin, and how does it evolve?* Here goes the story of the modern “warm adapted” human circadian cycle. Oh yeah, Dr. Kruse is a huge cold exposure enthusiast and takes his ice baths for up to an hour! We’ll learn about how cold therapy can positively impact metabolism and health, especially for post-menopausal women who feel like they’ve been tripping out! You will hear a lot about a couple of hormones, so I want to define them right out the gate: *Leptin* , a hormone released from the fat cells located in adipose tissues, sends signals to the hypothalamus in the brain. This particular hormone helps regulate and alter long-term food intake and energy expenditure, not just from one meal to the next. *Prolactin* is most commonly known as what prompts manuf of breast milk, but has a number of other important metab functions. It also regulates behavior, the immune system, metabolism, reproductive systems, and many different bodily fluids. This makes it a crucial hormone for overall health and well-being, for both men and women. Production of prolactin is controlled by two main hormones: *dopamine and estrogen.* These hormones send a message to the pituitary gland primarily indicating whether to begin or cease the production of prolactin. Dopamine restrains the production of prolactin, while estrogen increases it. Our brain wakes up with a morning surge of *cortisol*. That is what turns our brain on at 6am. *VIP* (vasoactive intestinal peptide) helps do this in long light cycles. VIP is highest at 6am, and lowest at 6pm. *Ghrelin* is also highest in the morning. Ghrelin is a prominent hunger hormone made in the stomach that has a half-life of one hour. Ghrelin sends a signal directly to our pituitary gland and it influences our metabolism. This is why the circadian cycle in the stomach in the morning is critical to optimal health. Kruse talks about the Leptin Rx reset protocol ( https://jackkruse.com/my-leptin-prescription/ ) on his blog. You’ll hear about *leptin* a lot in this story. It’s the prominent satiety, fat-storage hormone, and its main role is to prime you for reproductive fitness — our most basic and important biological drive. When leptin signaling is efficient between the brain and digestive system, you eat an optimal amount of calories. When leptin signaling is compromised due to assorted adverse lifestyle practices, you don’t get the satiety signal and you tend to store fat rather than burn it. I say ‘signaling’ rather than ‘low and high’ because it’s more nuanced than low and high. *Melatonin* secretion increases after four hours of darkness. This allows plasma leptin to enter the hypothalamus, if you are sensitive to its receptor. But, if you are leptin-resistant, this process can no longer occur. Now, onto the 24-hour tour of our circadian rhythm: *1.* Circadian cycles for the obese are dramatically altered compared to non-obese individuals in the morning. For non-obese people, ghrelin is high when cortisol is highest in the early morning. Ghrelin drops fast when food is eaten, too. But for the obese, ghrelin is much lower than expected in the morning. Moreover, once they eat food, ghrelin will stay elevated for an extended amount of time. *This is why* *obesity is an inflammatory brain disorder causing hormonal imbalance*. This happens because of the inflammation associated with the higher leptin levels in the morning in the obese. Melatonin is known to acutely decrease ghrelin (which is great for when you want to go to sleep). *2.* At 6:45am, we will expect to see the sharpest rise in blood pressure in the entire day. This is due to many activated systems in the body getting us ready to fully supply blood to all vital areas to get us motivated to begin our day and search for food. *This period of rapid blood pressure rise is why we see so many cardiac deaths occur in early morning sleep or early wakefulness.* This happens when cortisol is highest. *3.* Sun hits the retina at daybreak, and the photic stimulus begins to shut off the secretion of melatonin from the pineal gland in the brain. Morning sunlight contains mostly IR light at daybreak and as we approach noon, UV light frequencies appear on the skin. When morning sunlight hits your retina and receptors in skin cells throughout your body, the signal travels through the optic nerve to other regions of the brain, including the pineal gland. *The light cue prompts melatonin levels to fall and serotonin and cortisol to spike within 30 minutes of waking.* Adenosine levels decrease steadily as you sleep, and are low when you awaken, increasing alertness. *The adenosine-cortisol-serotonin effect is most effective closest to dawn* , another reason to try to rise with the light of day! *4.* At 7:30AM, usually after an hour of light, melatonin is completely shut off in the brain. *5.* At 8:30AM, the gut has been awakened and peristalsis becomes more vigorous and bowel movements getting rid of yesterday’s food are very likely. This happens as protons flow to move serotonin sulfated (that means snuffed out, like a battery) by the light of the gut microbiome to get to get to the brainstem to become sulfated melatonin (serotonin converts to melatonin in the evening). Bowel movement is stimulated if food is eaten around this time as well. This is called the *gastrocolic reflex*. Cortisol, aldosterone, and ghrelin are all raised at this time to drive activity, increase our blood pressure and stimulate feeding. This is all yoked to AM sunlight stimulus. It is blocked when we wear clothes or at work in the AM. *6.* Around 9-10AM, we have the highest secretions of the sex steroid hormones in humans and these pulsatile crescendos lead to our highest alertness at around 10AM in our day to allow us to explore our environment. So who knew the VIP time for sex was morning delight? *7.* Our ideal muscle coordination occurs at 2:30PM, which adapts us best to hunt for dinner at this time. An hour later, we see our fastest reaction times develop from our motor systems in our CNS. *8.* At 5PM, humans exhibit their greatest cardiovascular efficiency allowing for maximal exercising or hunting. This also occurs during a period of time when we have our best rates of protein synthesis in our body. *This is why exercise should be optimally done in this window.* *9.* As the sun falls at 6PM, we begin to see a major change in the cardiovascular system about a half hour later. *10.* At 6:30PM, we see our highest blood pressures due to changes in atrial natriuretic factor and antidiuretic hormone (ANF, ADH) in the renin-aldosterone axis. *11.* Once this occurs over the next 30 minutes (7PM), we begin to see a gradual rise in our body temperature as leptin (and IL-6) is released from our fat stores, with agouti’s help, slowly after dinner is eaten to signal the brain about our fat mass and inflammatory status. *Agouti* is a furry little rodent but also a *neuropeptide produced in the brain that has a powerful signaling effect to increase appetite, decrease metabolism and energy expenditure* , which is why it is known as one of the most potent and long lasting appetite stimulators. *12.* For the next two to three hours, leptin levels slowly rise as insulin levels fall. Adiponectin levels also fall during this time frame. These fat hormone signals are what activate the adenosine system in our bodies. Adenosine is created over the course of the day; you start in the AM with low levels, and as they build, high levels of adenosine lead to sleepiness. *13.* Adenosine peaks at 10PM ,and then the circadian clock allows for melatonin secretion after 3-4 hours of total darkness. Serum leptin is rising quickly now (with agouti’s help) as it is released from the fat cells to enter the brain. Agouti is highest at this time of the day, even in a normal person. *14.* As these trends continue, the GI tract is slowly shut down by the circadian clocks and around 11:30PM, bowel movements are shut down for the night. This means that the vagus nerve is quiet. *15.* At midnight, leptin begins to enter the hypothalamus to bind to its receptor - it signals energy reserves (you burn stored energy during the night). In diurnal animals, sleepiness occurs as the circadian element causes the release of the hormone melatonin and a gradual decrease in core body temperature. This drop in temperature is the stimulus to change sulfated serotonin to sulfated melatonin.  This timing is affected by one’s chronotype. *16. It is the circadian rhythm that determines the ideal timing of a correctly structured and restorative sleep episode*. Melatonin, the hormone from the pineal gland, called the “darkness hormone ” is of great importance in the functioning of the SCN - that’s the suprachiasmatic nucleus - located in the hypothalamus. Hypothalamus is the control tower for all hormonal and metabolic functions in the body, regulating body temperature, hunger, important aspects of parenting and attachment behaviours, thirst, fatigue, sleep, and circadian rhythms. SCN is the main arbiter of circadian rhythm in the body. Sunlight hits SCN and the hormonal cascades are kick started. The most important target of melatonin in humans appears to be the SCN, as the SCN contains the highest density for melatonin receptors. A double effect of melatonin in the SCN, namely, an immediate effect and long-term effect, has encouraged its worldwide use against the ill effects of jet lag. This may not be wise to do. As an immediate effect, melatonin is found to suppress neuronal SCN activity toward night time levels. During the daytime, the SCN neurons must run faster than normal.  This is possible because the retina has more DHA in it than the brain.  In terms of long-term effect, melatonin can phase shift and amplify circadian rhythmicity of the SCN. Melatonin application has been found to be useful in synchronizing the endogenous circadian rhythms not only in people who suffer from jet lag, but also in blind individuals, patients with dementia, and in shift workers. *17.* After the 4 hours of darkness, melatonin secretion increases and this allows plasma leptin to enter the hypothalamus, if we are sensitive to its receptor. *If we are leptin resistant, this process can no longer occur.* *18.* Once leptin enters and binds to its receptors, it affects the lateral hypothalamic tracts to immediately send a second messenger signal to the thyroid to signal it to up-regulate thyroid function and efficiency. This is how we can raise our basal metabolic rate when we are leptin sensitive. These coupled events, matched with leptin’s actions peripherally in muscles, occur at the UCP3 sites (these are mitochondrial uncoupling proteins) to burn fat as we sleep at a higher basal metabolic rate. This means electron chain transport does not make ATP as usual. When leptin allows this uncoupling to occur, we make heat (and not energy) from normal metabolism. This means we will burn off our excess calories as pure heat. *This is one reason why the whole ‘calories in and calories out’ argument makes no biological sense once you understand how leptin works.* *Humans are built to burn fat at night, as we sleep to lose excess weight we don’t need.* *19.* The timing of the leptin action is also critical. It usually occurs between 12-3AM, and *is tied to when you last ate and how much darkness your retina (SCN) have seen.* This generally occurs soon after our hypothalamus releases another hormone called prolactin, from our pituitary gland in the brain. *20. The surge of Prolactin* is normally quite large in normal darkness, but is significantly diminished in artificially lit environments after sunset. *The reason is that prolactin release is coordinated with sleep cycles where autophagy is at its highest efficiency and where Growth Hormone is released.* If this is diminished, we generally see lower DHEA levels clinically and higher IL-6 levels on cytokine arrays. This is a measure of uncoupling of sleep from normal metabolism. *I base every bio hack I do on this step in circadian biology because it is the most important.* *21.* *The normal large circadian prolactin surge we should see at around midnight after leptin enters the brain, does not happen if the patient has leptin resistance, sleep apnea, or has eaten food too close (within 3-4 hours) to bedtime.* This blocks leptin’s ability to enter the brain because of insulin spikes. As mentioned above, *this step is usually impaired if you are a post-menopausal female as well.* This is often why older women sleep badly and gain weight they can not seem to lose in the gym, even with a good paleo template and good habits.This is another reason *I am a big advocate for bioidentical hormone optimization in women.* This need is also greatest in women who are warm-adapted. *The need is lowest in the cold-adapted females* because their leptin levels are already low due to the cold. Post-menopausal women who are cold-adapted tend to do amazingly well clinically in most disease parameters in my clinical experience. The main problem they face is that their vanity and dogma keep them from using the cold pathways to become rockstars as they age. Thanks for listening to this journey around the circadian clock, and stay tuned for part 2! *TIMESTAMPS:* In this podcast, Brad talks about the work of Dr. Jack Kruse who believes that obesity is not caused by eating too many calories and not exercising enough. [01:23] Obesity begins in the eye…because of an altered spectrum light. [03:28] The timing of when you eat is more important than what you eat. [04:42] Snacking or eating small meals every two or three hours all but guarantees lifelong obesity. [05:31] People can lose massive amounts of weight without ever counting a calorie. [6:38] Processed carbohydrates are the true culprit and disease driver of the modern diet. [07:37] Leptin is a hormone released from fat cells located in the adipose tissues that sends signals to the brain. [09:42] Prolactin is the prompter of manufacturing breast milk but does much more. [10:49] Our brain wakes up in the morning with a surge of cortisol, the fight or flight hormone. Another hormone that is high in the morning is ghrelin, the appetite signal. [12:00] Leptin signaling is compromised by lifestyle practices, like too much artificial light after dark. [14:10] In the obese, ghrelin is much lower in the morning than expected and when food is eaten, it stays elevated. [15:34] As Brad goes through explaining the circadian rhythm process, we see that about 6:45 a.m. is when the blood pressure has the sharpest rise. [16:15] Around 7:30 a.m., usually after an hour of sunlight, melatonin is completely shut off. [19:00] The morning sunlight stimulus gets the other hormones going to increase activity. [20:45] Although we are primed to consume calories in the morning, it is really popular these days to try fasting. [21:30] Proceeding through the morning’s body rhythm, Brad points out that around 10:00 a.m. we have the highest secretion of sex steroid hormones. Ideal muscle coordination occurs at 2:30 p.m. [23:08] Around 5:00 p.m. is the best time for exercise. [24:54] It is important to have three or four hours of darkness in the evening. [27:03] At midnight, your body is still hard at work. [30:41] Having artificial lights on so that it doesn’t get dark is a huge health hazard. [32:56] If you don’t have a healthy metabolic function, you will not be burning fat as you sleep. [36:07] The timing of leptin is critical. It usually occurs between 12 and 3:00 a.m. [37:10] Post-menopausal women often find the timing of this evening meal impacts their ability to sleep well and they also gain weight regardless of their exercise and diet regimen. [39:07] There are many ways you can become cold-adapted. [40:10] *LINKS:* * Brad’s Shopping Page ( http://www.bradkearns.com/shop/ ) * Dr. Jack Kruse ( https://jackkruse.com/about-dr-jack-kruse/ ) * Jack Kruse Circadian Clock ( https://jackkruse.com/cold-thermogenesis-7/ ) * The Obesity Code ( https://www.amazon.com/Obesity-Code-Unlocking-Secrets-Weight/dp/1536682187 ) * Leptin RX Reset Protocol ( https://jackkruse.com/rewiring-the-leptin-rx-reset/ ) * Dr. Panda ( https://www.salk.edu/scientist/satchidananda-panda/ ) * Dr. Cate Shanahan ( https://drcate.com/ ) * Brad’s Cold Therapy ( https://www.youtube.com/watch?t=2s&v=AF6d9ngxnDo ) * Ghrelin ( https://www.google.com/search?aqs=chrome..69i57j0l7.3577j0j1&ie=UTF-8&oq=ghrelin&q=ghrelin&sourceid=chrome ) * Prolactin information ( https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/prolactin ) *QUOTES:* * "Obesity is not the result of too many calories, not enough exercise or living a slothful existence." * "The timing of when you eat is more important than what you eat." *Follow me on social media for more great content!* Instagram: @bradkearns1 ( https://www.instagram.com/bradkearns1/ ) Facebook: @bradkearnsjumphigh ( https://www.facebook.com/bradkearnsjumphigh ) Twitter: @bradleykearns ( https://twitter.com/bradleykearns ) *Sponsors* Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. 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