Podcasts about Ikaros

[Sign up to unlock the full episode and gain access to another 28 exclusive premium episodes! You will also help to make sure that I can expand my farming production and provide rice for the seniors in my village where the aisles are already empty of that staple food even though sowing has just begun and harvest is months away and the agricultural minister was fired this week. There is no famine in Japan, I'm not saying that, but it is ominous]Here we are once again. Back to the heart of the matter, the Biological Peace and Warfare stuff, which I hope was the reason you first came here? Well if not, so may this be, such a reason. We are going deep, deep down the Mines of Moria like you have never done before. A patreon exclusive dive in to the Holodomor. I've never felt more like Ikaros flying much too close to the Stalinist Tankie Sun, but I nonetheless do believe I survived and that I'm the wiser for it! Hope you listen, that you enjoy and that once you have enjoyed, that you tell me about it and others who need to know!

Mijal Schmidt is a licensed clinical psychologist with over 15 years of experience who's background is as diverse as the people she works with. Mijal blends her knowledge from different types of clinical settings and approaches with a structured traditional perspective around ethnobotanical elements. She sees psychedelics as a therapeutic means to access the unconscious while at the same time deciphering how consciousness can reflect and refract what it perceives and how that creates reality. This awareness is what led her to study the healing power of sound through Ikaros. In addition to individual sessions, Mijal offers lectures, courses, and workshops that explore the clinical aspects of psychedelic therapy and their profound therapeutic potential. She also trains, supervises and mentors teams and organizations to deliver ethical, responsible and professional practices while carefully understanding passionate and expansive plant work   Link: https://www.mijalschmidt.com/  

Why You Should Listen:  In this episode, you will learn about the use of GENIE testing in Chronic Inflammatory Response Syndrome. About My Guest: My guest for this episode is Dr. Ritchie Shoemaker.  Ritchie Shoemaker, MD is a recognized leader in patient care, research, and an education pioneer in the field of biotoxin related illness.  While illness acquired following exposure to the interior environment of water-damaged buildings (WDB) comprises the bulk of Dr. Shoemaker's daily practice, other illnesses caused by exposure to biologically-produced toxins are quite similar in their “final common pathway.”  What this means is that while the illness might begin acutely with exposure to fungi, spirochetes, apicomplexans, dinoflagellates and cyanobacteria, for example, in its chronic form, each of these illnesses has similar symptoms, lab findings, and Visual Contrast Sensitivity (VCS) findings.  Taken together the inflammatory illness from each of these diverse sources is known as  Chronic Inflammatory Response Syndrome. Key Takeaways: What is GENIE? Is HLA-DR still relevant? What are the common triggers of CIRS?  Actinobacteria?  Endotoxins?  Mold and mycotoxins? What is hypometabolism? How does CIRS impact insulin and blood sugar? What is apoptosis? What is the role of coagulation in CIRS? Are upregulated cytokines seen in CIRS? Can GENIE identify those that may have Lyme? What are defensins? What is Ikaros? What is the role of MAP kinases in CIRS? What do Toll receptors tell us? How are B and T cells involved in CIRS? How many CIRS markers are needed in GENIE to suggest CIRS? What is the PTSD gene? How often is histamine involved? What are the cytoskeleton and microtubules?  What can be determined around the function of Treg cells? What are the recent additions to GENIE in the realm of Parkinson's disease? What has GENIE told us about MARCoNS? Connect With My Guest:  http://SurvivingMold.com Interview Date: September 11, 2024 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode205. Additional Information: To learn more, visit https://BetterHealthGuy.com. Disclaimer:  The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority. 

Lars Lilliestam bygger sin forskning i musikvetenskap på långa intervjuer om hur och varför folk lyssnar på musik. Och hur musiken påverkar dem. Det har han forskat om i decennier och precis skrivit en ny bok. Lyssna på alla avsnitt i Sveriges Radio Play. ”Musik och människor - vad vi gör med musik och varför” heter hans bok, som sammanfattar både hans och andras forskning, som han stött på under alla de år han forskat och undervisat vid Göteborgs universitet. Han har skrivit den ”för vanligt folk” för att det är viktigt att forskning når utanför universitetsvärlden, säger han.I boken berättar han om kvinnan som haft Björn Afzelius sorgliga låt ”Ikaros” som följeslagare, killen som tog hjälp av Bruce Springsteens munspel när morfar hade dött och hur han själv fick gåshud och började gråta i bilen på väg till återvinningen bara för att en viss låt spelades på radio.Programmet sändes första gången den 19 juni.Lena Nordlundlena.nordlund@sverigesradio.se

Veckans gäst är författaren Chris Berg. Till vardags jobbar han som läkare, men när han inte agerar vardagshjälte så är det spänningsromaner med tung, nervig action som står på schemat.Det blir en intressant diskussion om vägen till författarskapet, inspirationen bakom böckerna och vikten av research. Chris är aktuell med Ikaros, som släpptes i våras. Det... Continue Reading →

Lars Lilliestam bygger sin forskning i musikvetenskap på långa intervjuer om hur och varför folk lyssnar på musik. Och hur musiken påverkar dem. Det har han forskat om i decennier och precis skrivit en ny bok. Lyssna på alla avsnitt i Sveriges Radio Play. ”Musik och människor - vad vi gör med musik och varför” heter hans bok, som sammanfattar både hans och andras forskning, som han stött på under alla de år han forskat och undervisat vid Göteborgs universitet. Han har skrivit den ”för vanligt folk” för att det är viktigt att forskning når utanför universitetsvärlden, säger han.I boken berättar han om kvinnan som haft Björn Afzelius sorgliga låt ”Ikaros” som följeslagare, killen som tog hjälp av Bruce Springsteens munspel när morfar hade dött och hur han själv fick gåshud och började gråta i bilen på väg till återvinningen bara för att en viss låt spelades på radio.Lena Nordlundlena.nordlund@sverigesradio.se

For personalized guidance, I'm offering podcast listeners a free 20-minute Thriving Mama Glow Assessment call. We'll evaluate your situation and, even if I'm not the right fit for you, I'll provide useful resources and support to help you on your journey.You can access the first 3 chapters of The Master Plant Experience and to learn more about the Quantum Drops you can check them out through Dr. Maya Shetreat's affiliate link.In this captivating episode of "The Thriving Mama," host Stephanie Davis dives deep with guest Dr. Maya Shetreat, exploring the transformative power of nature and using Quantum Drops in motherhood. Maya, a pediatric neurologist and plant medicine guru, navigates us through sensory experiences, community connections, and life transitions. All the while sharing her profound insights on healing, embracing the feminine, and nurturing our children. Stephanie opens up about her journey with Quantum Drops and reveals the profound impact they had. Join us on this enlightening journey to harmonize with nature, empower our intuition, and ultimately thrive as mothers. Dr. Maya Shetreat, MD, is a neurologist, herbalist, urban farmer, ceremonialist, and author of The Dirt Cure and the newly released The Master Plant Experience: The Science, Safety and Sacred Ceremony of Psychedelics. She has been featured in the New York Times, The Telegraph, NPR, Sky News, The Dr. Oz Show and more. Dr. Maya created Quantum Drops, a vibrational Master Plant product that is safe, legal, and deeply transformative. She is also the founder of the Terrain Institute, where she offers training for psychedelic-informed practitioners as well as an upcoming Quantum Practitioner Certification.Key Topics Discussed:Quantum drops and their integration into daily lifeNature's healing powers and plant medicineImportance of community in motherhoodEmbracing holistic approaches in healthcareRole of master plants in transformationTimestamps:10:03 Food is important for the immune system.16:09 Professional and personal journeys are nonlinear and unpredictable.17:05 Challenging societal norms to advocate for balance and truthfulness.21:04 Psychedelic plants are considered masters and grown for their reciprocity.24:10 Questioning doing something? Then discover a profound shift with Ayahuasca songs.33:16 Grief and loss held in collective consciousness.40:00 Supporting transition, integrating change, and connecting in the community.45:41 Using altered brainwaves for emotional and trauma work with plant-based ceremonies.48:07 Practicing intuition to stay centred as a mother.Guest Socials:Dr. Maya Shetreat | WebsiteQuantum Drops | Website

Lagom till jul har Emma bjudit in teologiprofessorn och prästen Petra Carlsson Redell till ARTpodden för ett samtal om kristendomens möjligheter att fungera vägledande i omställningen. Kan tron bidra med kraft till förändring och kan andlig närvaro öppna dörrar till mer omtänksamma förhållningssätt till det mer än mänskliga? I sin bok Gråstensteologi förespråkar Petra en glokal teologi där tro och andlighet utgår från marken snarare än himlen, från gossen Gråsten och fröken Granbuske, snarare än Ikaros. Hur kan vår kultur, djupt präglad av kristna läror och högtider, lära sig att landa innan vi bränner ut oss själva och planeten vi bebor? Det pratar vi om i årets sista avsnitt.

“Kinosaade” on taskuhääling, kus kino Artis programmijuht Ra Ragnar Novod, Forum Cinemas programmispetsialist Henryk Johan Novod ning kultuurikriitik Raiko Puust võtavad igal nädalal läbi uued filmid ja seriaalid ning ka olulisemad filmiuudised. Hakka meie toetajaks läbi Patreoni: www.patreon.com/kinosaade “Kinosaate” 217. saates arutavad Ragnar, Henryk ja Raiko nende filmide ja seriaalide üle, mida on nad vahepeal koduste vahendite (Amazon Prime Video, Netflix, Apple TV+ jne) abil vaadanud (Loki, The Fall of the House of Usher, Lupin, Futurama, Rick and Morty, Estonia jpm!) Lisaks anname ülevaate uutest kinofilmidest: Tähtsad ninad, Saag 10, Leo, Vaalamaailm, Ikaros ja Minotaurus, Lillekuu tapjad, Kohtumõistmise öö Vaata seda episood i Youtube'is: https://www.youtube.com/watch?v=ChPYiqxxXG0&ab_channel=Kinosaade Sisukord: 0:00 Sissejuhatus 6:09 Mida on Raiko kinos vaadanud? Eesti film "Tähtsad ninad" ja India film "Leo" 1:06:29 Mis filme ja seriaale on Henryk ja Ragnar kodus vaadanud? Ragnar: Estonia (2023 - ), Loki (2021– ), The Fall of the House of Usher (2023), Rick and Morty (2013– ) Henryk: Loki (2021– ), The Fall of the House of Usher (2023), Lupin (2021– ), Futurama (1999– ), Rick and Morty (2013– ), Storm Boy (2019) 2:02:23 Anname ülevaate uutest kinofilmidest: Saag 10, Leo, Vaalamaailm, Ikaros ja Minotaurus, Lillekuu tapjad, Kohtumõistmise öö 2:59:50 Mida saab uuel nädalal kinodes näha? Kõik saated on leitavad ka Kinosaade.ee, Apple Podcasts, Spotify ja kõikides teistes podcasti rakendustes. Lisaks leiab meid veel Facebookist, YouTubest ja Twitchist Kinosaade nime alt. Facebook: www.facebook.com/kinosaade YouTube: www.youtube.com/channel/UCeBOcl_yALcrk-U7Ou5BQCw Twitch: www.twitch.tv/kinosaade Kodulehekülg: kinosaade.ee/ Discord: discord.gg/B2zbCWPCc3 Patreon: www.patreon.com/kinosaade

Wagner-gruppens leder, Jevgenij Prigosjin, fløj for tæt på solen og styrtede – formentlig på Vladimir Putins foranledning – til jorden med et brag. Vi ser nærmere på, hvad det betyder for Wagner-gruppen fremover, inden vi runder slagmarken Ukraine, hvor et ukrainsk gennembrud kan være på vej. Til sidst forklarer forfatter til bogen ”Kampen om Taiwan” Jonas Parello-Plesner, hvorfor striden mellem kinesere og taiwanesere kommer os ved. Oversigt: - Usikkerhed om Wagner-gruppens rolle efter Prigosjins død - Er Ukraines sommeroffensiv ved at lykkes? - Forsvarsministeriet venter stadig på ny departementschef - ”Kampen om Taiwan” Vært og tilrettelægger: Peter Ernstved Rasmussen. Tilrettelægger: Kasper Junge Wester Medvirkende: Niklas Rendboe (projektforsker, Forsvarsakademiet), Kenneth Øhlenschlæger Buhl (militæranalytiker, Forsvarsakademiet), Hans Engell (politisk kommentator) og Jonas Parello-Plesner (forfatter og direktør for Alliance of Democracies)See omnystudio.com/listener for privacy information.

UPPLÄSNING: Johan Svensson DIKTSAMLING: Ikaros Död ( FIB:s Lyrikklubb 2001)MUSIK: Ballaké Sissoko: Kalanso EXEKUTÖR: Ballaké Sissoko, kora

Max Verstappen närmar sig solen, som han, med sina Red Bull-vingar, flugit närmare och närmare. Max radiotrafik rör upp jämförelser med den grekiska mytologin. Utöver att snacka Belgiens GP, Spa och sprintupplägg så lyssnar vi på Hans G Lindskog, på Mupparna och på George Russels regnsamtal med Toto Wolff. Andra snackpunkter från racehelgen är Ottmar Szafnauer-effekten, Sainz+Ferrari, och sen krävs en vända till kring Sergio Perez efter att Dr Marko uttalat sig i frågan. Häng med oss in i F1:s sommaruppehåll.

Support this show http://supporter.acast.com/gott-snack-med-fredrik-soderholm. Hosted on Acast. See acast.com/privacy for more information.

"Självbiografi" är en av poeten Sonja Åkessons mest kända dikter, som börjar "Jag lever ett lugnt liv i närheten av tunnelbanan". Man ska dock inte se den som en hemmafrus självbiografi. Lyssna på alla avsnitt i Sveriges Radio Play. Den skrevs som replik till den amerikanske poeten Lawrence Ferlinghettis långa dikt femtiotalsdikt "Autobiography" men istället för en man som likt Ikaros flyger för nära solen har vi här en kvinna som skyndar hem för att inte bränna vid potatisen.Ur radioarkivet bland andra Sonja Åkesson, Ingrid Hiort af Ornäs och Carl Magnus von Seth.

Wir sehen die Helden der letzten Folgen sterben und verfolgen weiter die Reisen des Theseus. Athen steigt wie ein Phönix aus der Asche, die Amazonen rächen sich, Phädra verliebt sich in ihren Stiefsohn Hippolythos und Theseus geht mit einem Freund in die Unterwelt. Kommt er zurück? Mit: Minos, Daidalos, Theseus, Ikaros, Kokalos und seine Töchter, Kreta, Naukrate, Minotaur, Aigeus, Athen, Attika, Lykos, Nisos, Pallas und seine 50 Söhne, Marathon, Herakles, Mykene, Sparta, Arkadien, Isthmus, der kretische Stier, Phönix, Amazonen, das schwarze Meer, Hippolyte, Antiope, Ariadne, Phädra, Deukalion, Hippolytos, Pitteus, Troizen, Aphrodite, Euripides, Racine, Peirithoos, Helena, Kentauren, Hippodameia, Persephone, Hades, Okeanos, Charon, Kerberus, Herakles, Styx, Dioskuren, Aithra, Menestheus, Lykomedes, Skyros. Instagram: @chaos.kinder Spende über PAYPAL: https://www.paypal.com/donate/?hosted_button_id=VB2QKC88H9NYJ#

In dieser Folge mache ich dem Namen des Podcasts alle Ehre: SO viele unterschiedliche Figuren! Wer war noch mal wer? Hier eine kleine Übersicht: KRETA Minos + Pasiphae, Ariadne (Tochter), Androgeus (Sohn), Minotauros (Sohn von Pasiphae+Stier) Daidalos (Erfinder), Ikaros (Sohn) ATTIKA Aigeus, Theseus (Sohn mit Aitra), Medos (Sohn mit Medea) TROIZEN Pitteus (Freund von Aigeus), Aitra (Tochter)

Interview with SpaceX Crew-5 JAXA astronaut, Dr. Koichi Wakata (re-release interview from 2020).  Dr. Koichi Wakata has accumulated more than 350 days in space spanning five missions, setting a record in Japanese human space flight history for the longest stay in space. He has flown on three space shuttle missions, and a Soyuz mission, and became the first Japanese Commander of the International Space Station. Dr. Wakata has held several key positions with JAXA, the Japan Aerospace Exploration Agency, including serving as JAXA Vice President and Senior Advisor.With the Crew 5 mission, Dr. Wakata made his fifth trip to space and now that he's aboard the International Space Station, he will serve as a flight engineer for Expedition 68. Dragon was the third different type of spacecraft Dr. Wakata has flown to space. In this interview (from 2020), we discuss how Dr. Wakata became an astronaut, plus JAXA missions such as Hayabusa2, IKAROS, JUICE (Jupiter Icy Moons Explorer) and MMX (Martian Moons Exploration). For more information, visit https://global.jaxa.jp/ 

Wenn man durchs All fliegen will, braucht man Raketen. Ja, aber es ginge auch anders. Und zwar mit "Weltraumsegelschiffen" die durch Licht getrieben werden. Wie das geht erfahrt ihr in der neuen Folge der Sternengeschichten. Wer den Podcast finanziell unterstützen möchte, kann das hier tun: Mit PayPal (https://www.paypal.me/florianfreistetter), Patreon (https://www.patreon.com/sternengeschichten) oder Steady (https://steadyhq.com/sternengeschichten)

Varje vecka väljer en medarbetare på kulturredaktionen ett ord som på något sätt ringar in vår samtid. Denna vecka är det Mattias Berg som väljer "himmelsfärd". Kristi Himmelsfärd har firats sedan år 375. Samma år som hunnerna visade sig för första gången och Kejsar Gratianus inledde sin systematiska förföljelse av hedningar.Helgen ersatte den tidigare hedniska högtiden "Betessläppningen" - som dock märks än i dag ungefär vid den här tiden. Men då kallas det oftast "Kosläpp". Sedan Ikaros och André har de flesta av oss gjort en sorts himmelsfärder, i flygmaskin, och fått se molnen ovanifrån. En del har till och med rest upp i rymden och fått se hela jorden uppifrån. Jag får googla den här helgen, på samma sätt som nästan varje år. Kristi Himmelsfärd. Den högtid vi i vårt sekulariserade samhälle enligt vissa undersökningar det allra minst troende i världen ändå firar så grundligt. Det vill säga genom att ta helt ledigt om det går. Gärna med en så kallad klämdag efter, på fredagen, om vi kan. Som väl är det enda sätt som vi i vårt till stora delar icke-troende samhälle verkligen firar en religiös helgdag på.Detta alltså för vad som kallas Kristi Himmelsfärd. Eller Kristi Him, som vi brukar säga med vardaglig förkortning av helgen. Som ändå behåller det högtidliga genitivet: Kristi, det vill säga Kristus, himmelsfärd ett kasus som nästan inga andra uttryck har kvar i dagens svenska. Även när helgen ännu mer vardagligt kallas Kristi Flygare.Och det är här någonstans jag börjar googla.Läser att Kristi Himmelsfärd har firats ända sedan år 375.Samma år som hunnerna till exempel visade sig i Sydryssland, som ett varsel om vad som komma skulle: om den citat mörka medeltiden.Och samma år som den romerske kejsaren Gratianus, vilket väl också var ett slags varsel, påbörjade den systematiska förföljelsen av hedningar. Alltså vad som i modernt managementspråk kallas implementering av den nya kristna läran.Det är också efter den vi firar den här helgdagen. För att högtidlighålla att Jesus efter Uppståndelsen fördes upp till himlen och lämnade oss människor kvar med bara oss själva här på jorden. I själens obotliga ensamhet, som Hjalmar Söderberg skrev.Jag går ut, tittar upp bland molnen och smakar på ordet Himmelsfärd. Tänker på andra med högtflygande planer. På den antika mytens Ikaros, där vingarnas vax smälte när han kom alltför nära solen, och på vår egen Ingenjör Andrée med sin ungefär lika misslyckade luftfärd. På att nog de flesta av oss människor sedan dess fått se molnen även ovanifrån när vi flyger och en utvald skara kommit långt ut i universum: då till och med fått se hela jorden ovanifrån.Är det också en himmelsfärd, kan man undra. För var himlen börjar har vi nog diffust klart för oss där uppe någonstans men var slutar den egentligen? Jag går in igen, läser vidare. Om att Kristi Him ersatte en tidigare högtid i det hedniska samhället, innan implementeringen av kristendomen av Gratianus och andra alltså tog sin början. Den högtiden kallades Betessläppningen. Av bokstavligen naturliga skäl: eftersom det helt enkelt var då man släppte ut korna på grönbete igen.Detta sker förstås än i dag, ungefär nu. Dock utan tillhörande högtid mer formellt även om det fortfarande kallas Kosläpp och arrangeras inför inbjuden publik lite här och var.När barnen hade det med skolan minns jag att de fick med sig hem en vacker, yster upplevelse av djur i nästan frihet. Plus varsitt mjölkglas med en ko utanpå från det stora mejeriföretaget.Det är väl också ett sätt att högtidlighålla något i ett delvis så sekulariserat samhälle. Där naturen ofta får ta religionens plats, i våra hjärtan om än inte i själva almanackan längre.

I gush over and play Project Ikaros: a super-slim, self-contained, lo-fi sci-fi RPG about elite agents pursuing rogue psychics that belongs to the modular 2400 series of micro-rpgs. Riley as Agent Burke Support this show further on patreon: https://www.patreon.com/idegoanddice?fan_landing=true Follow us on instagram! https://www.instagram.com/idegodice/ 

Morgan ospite in diretta, al telefono, di Tatiana Fabbrizio e Boris Sollazzo durante “Gagarin”, per presentare i nuovi episodi di “Ikaros”: podcast condotto e ideato dal cantautore, già leader dei Bluvertigo, dedicato agli artisti “bruciati troppo in fretta”. Podcast del 19 gennaio 2022.

Ο Skive, παραγωγός, mix engineer, επικεφαλής και συνιδριτής της Capital Music, ενός από τα πιο επιτυχημένα ελληνικά music labels της τελευταίας δεκαετίας, έρχεται στο Rap Cafe. Ο ανταγωνισμός, το ραπ, το τραπ, η άνοδος της εγχώριας μουσικής βιομηχανίας αλλά και ο ρόλος του Mad Clip, σε μια πλήρη συζήτηση που δημοσιεύεται σε δυο μέρη.Τo part 2 τώρα διαθέσιμο. Do you want FREE pizza? : https://bit.ly/2JYhQUZMore Links: https://bit.ly/36pq8MP  Location: Red Light StudioFilmed by: Damian AronidisEdit by: Giannis Stasinopoulos Find us here:Legal Pizza: https://www.instagram.com/legalpizza.gr​Ανδρέας: https://www.instagram.com/andreasperiklesΓιάννης: https://www.instagram.com/giannis.redlightΚώστας: https://www.instagram.com/karus_ikaros​Skive: https://www.instagram.com/skivebeentrillRap Cafe #18 - Skive (Part 2) #RapCafe​ #18 #Skive

Ο Skive, παραγωγός, mix engineer, επικεφαλής και συνιδριτής της Capital Music, ενός από τα πιο επιτυχημένα ελληνικά music labels της τελευταίας δεκαετίας, έρχεται στο Rap Cafe. Ο ανταγωνισμός, το ραπ, το τραπ, η άνοδος της εγχώριας μουσικής βιομηχανίας αλλά και ο ρόλος του Mad Clip, σε μια πλήρη συζήτηση που δημοσιεύεται σε δυο μέρη.Τo part 1 τώρα διαθέσιμο. Do you want FREE pizza? : https://bit.ly/2JYhQUZMore Links: https://bit.ly/36pq8MP  Location: Red Light StudioFilmed by: Damian AronidisEdit by: Giannis Stasinopoulos Find us here:Legal Pizza: https://www.instagram.com/legalpizza.gr​Ανδρέας: https://www.instagram.com/andreasperiklesΓιάννης: https://www.instagram.com/giannis.redlightΚώστας: https://www.instagram.com/karus_ikaros​Skive: https://www.instagram.com/skivebeentrillRap Cafe #18 - Skive (Part 1) #RapCafe​ #18 #Skive 

Kapteinen på Titanic trodde han hadde kommandoen over et skip som ikke kunne synke. Isfjell var ikke noe å bry seg om. Bak det grønne skiftet ligger en tro på teknologisk overlegenhet som minner om både Titanic og lenger tilbake – Ikaros – som fløy for nær solen. Menneskets hybris er gammel som historien, men selv historien har vi frigjort oss fra. Vi tror ikke den gjelder oss. Sannhetens øyeblikk slo inn med brutal kraft: De høye strømprisene og elbiler etterlatt langs norske og svenske veier er vitnesbyrd om en sivilisasjon som tror den kan trosse, ikke bare økonomisk tyngdekraft, men logikk og sunn fornuft. At det finnes et Norge skyldes at våre forgjengere respekterte livets lover, kampen for tilværelsen og visse grunnleggende sannheter. Ordspråkene viser at det er gammel kunnskap: Du kan ikke få noe ut av ingenting. Men det mente våre politikere. De ville avvikle industrisamfunnet og ga seg til å spille hasard med folks energitilførsel. Nå blør hele Europa. Samtidig har de satt i gang en befolkningsutskiftning som alle har kunnet observere i årtier, men som heller ikke må kalles ved sitt rette navn. Denne koster astronomiske summer og vil aldri bli lønnsom. Likevel fortsetter medier og politikere å messe om dens velsignelser. Et isfjell kan anta mange former. Lag en konto på Odysee her! – Odysee vil da gi oss poeng som hjelper oss å klatre i algoritmene! Følg oss på Rumble. Følg oss også på PodBean, iTunes og alle steder der podcasts finnes. Husk å rate oss med 5 stjerner, så flere likesinnede sannhetssøkere finner oss der! Kjøp Alf R. Jacobsens politiske bombe «Stalins svøpe: KGB, AP og kommunismens medløpere» her!

Ο νεαρός filmmaker και φωτογράφος από τη Θεσσαλονίκη παρουσιάζει αγαπημένους Έλληνες rappers μέσα από τη σειρά "Raps On The Run". Η ιστορία του όμως δεν τελειώνει εκεί. Μέχρι τα 22 του έχει προλάβει να ταξιδέψει τον κόσμο φωτογραφίζοντας μεγάλα events και φτάνοντας να συνεργάζεται με τον Cordae σε tour.Γνωρίστε τον άνθρωπο πίσω από τα μονόλεπτα rap music videos στο νέο επεισόδιο Rap Cafe. Do you want FREE pizza? : https://bit.ly/2JYhQUZMore Links: https://bit.ly/36pq8MP  Location: Red Light StudioFilmed by: Damian AronidisEdit by: Giannis Stasinopoulos Find us here:Legal Pizza: https://www.instagram.com/legalpizza.gr​Ανδρέας: https://www.instagram.com/andreasperiklesΓιάννης: https://www.instagram.com/giannis.redlightΚώστας: https://www.instagram.com/karus_ikaros​Nikos On The Run: https://www.instagram.com/nikosontherun Rap Cafe #17 - - Ο Nikos On The Run γυρίζει τον κόσμο για το πάθος του #RapCafe​ #17 #RapsOnTheRun 

Λίγες μέρες πριν το κυκλοφορία του νέου mixtape του με τίτλο DFFRNT και ενώ το single Blockstar μαζί με τον Thug Slime τρέχει στις τάσεις, καθίσαμε και συζητήσαμε με τον Gio Melody για όλα αυτά που τον έφεραν στο σήμερα. Η ζωή στη Γερμανία, η εφηβεία στη Χαλκίδα, η μετάβαση στην Αθήνα και ο συνεχής αγώνας για καθιέρωση. Do you want FREE pizza? : https://bit.ly/2JYhQUZMore Links: https://bit.ly/36pq8MP Location: Red Light StudioFilmed by: Damian AronidisEdit by: Giannis Stasinopoulos Find us here:Legal Pizza: https://www.instagram.com/legalpizza.gr​Ανδρέας: https://www.instagram.com/andreasperiklesΓιάννης: https://www.instagram.com/giannis.redlightΚώστας: https://www.instagram.com/karus_ikaros​Gio Melody: https://www.instagram.com/darkrnbgoat Rap Cafe #16 - Ο Gio Melody ήξερε πάντα ότι είναι DFFRNT#RapCafe​ #16 #GioMelody

After starting out as an investment banker in London, Daniel quickly figured that he didn't want to be just another cog in the machine. Always having had an analytical streak, the convergence of marketing, analytics, product and many more disciplines into “growth” turned out to make growth marketing the perfect fit for him.Having worked as Head of Growth and Data Insights at Sellable, a Sydney prop-tech start-up, Daniel decided it was time to start out himself and build ikaros, a now-established boutique growth marketing and analytics consultancy leveraging data to deliver high-performance growth strategies for scale-ups and SMEs. What you will learn in this episode:Two factors analytics helps with for any early stage businessGoing beyond knowing the customer's first name for marketing personalisationHow to use pirate metrics and acquisition elements  to map out your customer journeyHow to apply cohort analysisHow to start collecting  data in a realm of “data-geddon”How to monitor the right KPIsDaniel's documenting and process behind growth experimentsWhy doing things that don't scale is importantHow Daniel drastically improved a direct marketing campaignHow to monitor the effectiveness of offline marketing strategiesPicking the right marketing channelPrioritising your ideasThe “7 friends in ten days”  frameworkAt the end of the episode, Daniel's weekly challenge for your growth team. Resources mentioned:ikarosRocket InternetDeutsche Bahn “No need to fly” campaign Pirate metricsSegmentHeapSellableTwilio Autopilot VeroStripe founder Patrick CollisonEtsyThe 80/20 ruleLean startup principleICE framework7 friends in ten days Reading recommendations:Andrew Chen's blogs What business would you build on Mars?I'm thinking about luxury items. Think about plant-based items...If you're taking seeds for example, it's like very little mass that you need to take to Mars, which obviously, mass is really valuable for you. If you can,  successfully grow something even if it's just in your bank or so on Mars and sell that maybe back on earth, that's going to be like a novelty,  really unique, luxury item. So it's obviously going to command a massive markup. Reach Daniel here:on Linkedin

In ihrem Mythologie Podcast für Kulturbanausen reden Steffi und Sarah heute erneut über eine Geschichte aus der griechischen Mythologie. Sarah erläutert Steffi und allen Zuhörenden sehr eindrucksvoll am Beispiel der Geschichte des griechischen Erfinders Daidalos und dessen Sohn Ikaros, warum ihnen ihr derzeitiger Höhenflug voraussichtlich nicht besonders gut bekommen wird.

It's another week and the guys have on the incredible Ethan Gallardo. You might have heard Ethan as Manual in My Hero Academia or even Ikaros and Senor Pink in One Piece! The guys are talking all about Ethan's career with Funimation, filming movies in another country and over dubbing Japanese live action. Be ready to laugh and have a blast and learn all about Ethan and his life. As always make sure you support the podcast by rating and subscribing to us on Apple Podcast, it really helps us out in the algorithms, you can also listen on all podcast platforms. You can find those by clicking the link below:https://pod.link/levelingupbanksAlso, make sure you subscribe to the YouTube channel where we post a brand new video everyday and upload the video portion of this episode on Friday. You can find that by clicking the link below:https://www.youtube.com/c/LevelingUpwithBenjaminBanksSupport the show (https://www.patreon.com/LevelingUpBanks)

Welcome to Episode 36 of the Damn Dude Podcast!Part 6 of The Journey to Inner Peace!Ayahuasca Ceremonies, going into the 4th ceremony!Ikaros really take you on the journeys that you need to go on.Living through the worst pain ever imaginable, having to experience the deaths of loved ones all at one time, equaled 2 days of the worst misery ever found.Visiting loved ones in their dreams and having memorable conversations that we were able to actually go back and discuss and recall!It actually changed real life relationship with parents!Maestro became a Totem Pole.Maestro physically Stomped through the floor during ceremony.Healing self to the point of being able to help heal others through energy and music!Throwing green energy, evolving thinking, habits, and thoughts.Headed to the Discoteka and meeting Abraham Lincoln in the amazon Jungle....Part 7, Next! Remember to say 3 things you're Gratful for every morning and every night!- Available on all major platforms!IG/FB: @DamnDudePodcasatAvailable on all major platforms: https://damndudepodcast.buzzsprout.com/- Apple Podcasts- Buzzspout- Spotify- Google Podcasts- Amazon Music- iTunes- Stitcher- iHeart Radio- TuneIn + Alexa- Podcast Addict- PodChaser- Pocket Casts- Deezer- Listen Notes- Player Fm- Podcast Index- Overcast- Castro- Castbox- Podfriend- YouTubeDaaaaaaamn Duuuuuude!!!!!Be sure to leave a 5 Star written review on Apple Podcast/Listen Notes! :)If you'd love and support the show, please feel free to make a donation to the Damn Dude Podcast!(link below)Anything and everything is Appreciated! :) Much Love, Love All.Support the show (https://paypal.me/DamnDudePodcast?locale.x=en_US)

Diskussionen om vad en dikt ska vara - och inte - har pågått åtminstone sedan antiken. En viktig fråga är hur dikten ska förhålla sig till verkligheten. Teodor Stig-Matz synar oenigheten i denna fråga bland några av 1900-talets stora poeter. ESSÄ: Detta är en text där skribenten reflekterar över ett ämne eller ett verk. Åsikter som uttrycks är skribentens egna. Är du för eller emot verkligheten? Det kanske låter som en märklig fråga ingenting att bråka om; verkligheten är ju verkligheten, den bara är men för flera av 1900-talets stora poeter var den både infekterad och central. Ta till exempel svensken Werner Aspenström. En av hans mest älskade dikter, Ikaros och gossen Gråsten från 1956, inleds så här: Efter att ha läst 73 (förträffliga) dikter om Ikaros önskar jag lägga ett ord för hans lantlige kusin, gossen Gråsten, kvarlämnad på ängen. Det är en hyllning av det jordnära kontra det mytiska, det fysiska kontra det metafysiska, det småskaliga kontra det storslagna. Är du för eller emot verkligheten? Vissa såg gossen Gråsten som ett direkt svar på Erik Lindegrens dikt Ikaros från 1954. Inte särskilt konstigt; dels känns Aspenströms användande av just Ikaros som exempel som en diss hemmahörande mer bland nutida rappare än de svenska fyrtiotalisterna dels skriver Lindegren i sin dikt om att störta den verklighet som Aspenström håller så mycket av. Aspenström själv menade att dikten inte hade något med Lindegren att göra. Men icke-konflikten väcker ändå intressanta frågor om poesin i stort: Vilka ämnen ska den behandla? För vem är den till, de breda folkmassorna eller de som redan på förhand kan sin litteraturhistoria? Ska den sikta mot stjärnorna eller stanna kvar på jorden? Ungefär 30 år tidigare verkade två amerikanska poeter, T.S. Eliot och William Carlos Williams, på varsin sida av just dessa skiljelinjer. Båda var modernister starkt influerade av Ezra Pounds imagism, men där den förstnämndes diktning är akademisk och refererande har den andres en kärlek till allt som har med naturen och det folkliga att göra. Och precis som i fallet Aspenström/Lindegren illustreras det skilda synsättet mellan dem bäst med två dikter: Eliots Det öde landet och Williams Paterson. Det öde landet har kallats för ett av 1900-talets viktigaste litterära verk. På 434 rader uppdelade i fem delar trycker Eliot ur sig bilder som är lika knivskarpa som de är kryptiska, lika domedagsdoftande som de är vackra. Framför allt är det en dikt som känns som att gå in på sin lokala pizzeria och be om extra allt. Här finns och det är bara en bråkdel av alla hundratals referenser myten om den heliga graal och bilder av första världskrigets fasor. Här finns hinduismen, kristendomen och buddhismen. Här finns referenser till Shakespeare och Dante, Ovidius och Augustinus, Baudelaire och Verlaine, Richard Wagner och barnvisan London Bridge is Falling Down. Dessutom använder sig Eliot av inte mindre än sex språk förutom engelskan: latin, grekiska, italienska, tyska, franska och sanskrit. William Carlos Williams avskydde Det öde landet William Carlos Williams avskydde Det öde landet och, till skillnad från Aspenström, var han helt öppen med sitt ogillande. I sin självbiografi kallar Williams dikten en katastrof för litteraturen. Den kritik han själv tar upp handlar om att Eliot med sitt överflöd av referenser, sitt bitvisa användande av versmått och sina språkbyten förde poesin tillbaka till akademin. Williams menade att den amerikanska lyriken sedan Walt Whitman, på andra sidan sekelskiftet, hade rört sig i en mer folklig riktning, med ett språk som gemene man kunde förstå. Detta var han nu rädd att Eliot skulle sätta stopp för. Men Williams hat gentemot Det öde landet skulle också kunna förklaras med vilka de båda poeterna var som personer, och hur detta i sin tur formade deras diktning. Williams hade förvisso en mångkulturell bakgrund hans mamma var från Puerto Rico och i barndomshemmet pratades det spanska men någon kosmopolit var han knappast. Amerika, och speciellt miljöerna runt hemstaden Rutherford i delstaten New Jersey, var det han höll närmast hjärtat. Hela sitt vuxna liv arbetade han som läkare där, och kontakten med patienterna utgjorde, tillsammans med den lokala naturen, de stora inspirationskällorna. Eliot däremot var en riktig världsmedborgare. Efter att ha tagit examen från Harvard drog han till Paris och pluggade filosofi. Som 25-åring flyttade han till Storbritannien och han sa senare upp sitt amerikanska medborgarskap. Kosmopolitismen märks av på flera ställen i Det öde landet, bland annat i denna passage: vad är det för stad över bergen störtar och formas om och brister i luftens lila torn som faller Jerusalem, Aten, Alexandria, Wien, London overkliga. Det är enkelt att föreställa sig att Williams inte tyckte om dessa rader. Dels har vi det globala: fem metropoler nämns på två rader, dels har vi det faktum att Eliot kallar städerna overkliga och dessutom kryddar på med bilder av fallande lila torn. Overkligheten var det sista Willams var intresserad av för honom var det i människorna och tingen som allt det viktiga och vackra fanns att hämta. Eposet Paterson, som av många setts som ett svar till Det öde landet, innehåller de främsta exemplen på denna världsåskådning. Williams dikt är precis som Eliots skriven i fem delar.  Men där den senare är relativt kort det tar inte mer än 15 minuter att läsa Det öde landet i normal takt är Paterson med sina 250 sidor betydligt maffigare. Bortsett från sidantalet är dock allt med Williams dikt mindre än Det öde landet. Där Eliot rör sig fritt över världen, mellan meter och fri vers, fantasi och verklighet, är Williams lågmält betraktande och skildrar bara en enda plats. Den lilla staden Paterson, där eposet nästan uteslutande utspelar sig och från vilken den fått sitt namn, ligger en kort stund från Williams hemort. Han brukade åka dit på hembesök i sin yrkesroll som läkare och fascinerades av byggnaderna, människorna, och av det väldiga vattenfall från vilket stadens gryende industri hämtade sin energi. Paterson blev en ram för dikten, men inte bara det: staden fungerar även som en levande organism, som en metafor för Williams själv och för livet i stort. I vissa passager är Paterson en stad, i andra en man sin livskraft hämtar han alltid från vattenfallet och floden i vilken det störtar ner. Dikt blandas med små prosastycken innehållande berättelser från stadens historia, och hela tiden strävar poeten efter att hålla fast vid den metod han sammanfattar i eposets inledning: Säg det: inga idéer utom i tingen ingenting utom husens tomma ansikten och cylindriska träd böjda, kluvna av fördom och slump splittrade, fårade, skrynklade, fläckade hemliga ända in till ljusets kropp! Så, vem hade rätt, Williams eller Eliot, Aspenström eller Lindegren? Ska vi vända oss till gossen Gråsten eller till Ikaros till den samlade världslitteraturens kunskap eller till det vackra i en liten blomma när vi söker svar på livets gåtor via poesin? Är du för eller emot verkligheten? Du kan så klart ha en åsikt i frågan det hade trots allt poeterna själva men du behöver inte heller välja. För att citera Louise Glück, 2020 års Nobelpristagare i litteratur, om Elliot och Williams: Jag älskar båda de här poeterna, hela tiden. Teodor Stig-Matz

Die Flamme der Kerze erlischt im geschmolzenen Wachs - ein erneutes Anzünden bleibt erfolglos. Der einzige Weg, die Kerzenreste vor dem Gang zur Mülltonne zu bewahren, ist die eigenen vier Wände in eine kleine DIY-Werkstatt zu verwandeln und sich beim Kerzenziehen auszuprobieren. Aber Achtung: Das heiße, flüssige Wachs ist tückischer als es aussieht... Das haben laut den alten Griechen auch Daidalos und Ikaros am eigenen Leib zu spüren bekommen. Georgia Tsonis liest euch diese mündlich überlieferte griechische Sage vor. Das ist der Link zum Text: https://www.projekt-gutenberg.org/antholog/s-griechen/chap003.html

Hi, I am here with Greg Lawrence, He is a Psychedelic Integration and Transformational Coach, Energy Worker, and active member of the Southern California psychedelic community.CHECK THIS AMAZING WEBSITE BY GREG TO LEARN MORE:https://psychedelicintegrationspecial...JOIN NOW!! AND BE PART OF MASTERMIND PROGRAMlearn how to activate yourself for a better future!https://createanewtomorrow.com/master...CHECK THIS LINK FOR A FREE GIFT FOR YOU!https://www.createanewtomorrow.com/giftDO YOU WANT TO BE OUR NEXT SPECIAL GUEST?Book an appointment now and let's create a new world together!https://booking.builderall.com/calend...CHECK THIS OTHER WEBSITE FOR MORE INFORMATION!https://www.CreateAnewtomorrow.comhttps://www.Achievehealthusa.comCreate a fundamental change in the global community from a strictly reactive system of medicine that focuses on symptom and emergency treatment to a proactive system based on whole-being health as well as illness and injury prevention. Personally teach and influence at least one million people.We are a multifaceted Health and Wellness company that specializes in Corporate Wellness and Culture Consulting, Industry Speaking engagements and Continuing education for the industry.We Help corporations by solving the most costly problems they have with Productivity and Health Care while creating a culture that thrives on accomplishment and community.We help organizations think outside of the box and gain tools that allow them to be nimble and strong as tides and markets shift.We Up level the skills and tools of other practitioners by providing them continuing education that actually leads to greater success and standing in the business community.++++++++++++++++++++++++++++++++++++++++++++++++++++Ari Gronich 0:00  Has it occurred to you that the systems we live by are not designed to get results? We pay for procedures instead of outcomes, focusing on emergencies rather than preventing disease and living a healthy lifestyle. For over 25 years, I've taken care of Olympians Paralympians a list actors in fortune 1000 companies, if I do not get results, they do not get results. I realized that while powerful people who control the system want to keep the status quo, if I were to educate the masses, you would demand change. So I'm taking the gloves off and going after the systems as they are. Join me on my mission to create a new tomorrow as I chat with industry experts, elite athletes, thought leaders and government officials about how we activate our vision for a better world. We may agree and we may disagree, but I'm not backing down. I'm Ari Gronich. And this is create a new tomorrow podcast.Welcome back to another episode of create a new tomorrow. I'm your host, Ari Gronich and I have with me, Greg Lawrence, and Greg is a psychedelic integration and transformational coach. He's talks about clinical research, micro dosing, the importance of preparation and integration. What would you, Greg, you know, like to share about how you got into this field, and what about it is makes it so passionate for you?Greg Lawrence 1:36  Wow. Well, I mean, I got into it through experience about six years ago. Well, I should back up and say that I use psychedelics in my late teens through my late 20s. And unfortunately, in my late 20s, I also got mixed up with hard drugs, my life spiraled out of control pretty quickly. So I managed to scrape myself off of the bottom of the barrel and quit drugs, cold turkey, everything except cannabis cannabis, which I've used for many years after that, when I moved away from where I was, I stopped using everything but cannabis, and I live basically a suburban lifestyle for about 25 years. And about six years ago, my life got turned upside down through personal tragedy. I realized at that time, I had a lot of unresolved childhood trauma I hadn't dealt with, and I basically been hiding for a long time. So I started working with a psychotherapist, personal coach, and somewhere in there where I was smoking cigarettes and trying to quit, and my coach said, I think soul assignment helps with that. So I got some magic mushrooms and took them and had some epiphanies about what was going on in my life and the causes of the misery I was experiencing. And I thought, okay, now that I know where that came from, everything is going to change. And in about four or five weeks or so everything was just the same as it was. That happened a couple more times, then I stumbled across the concept of integration, and started going to integration groups, integration circles. And that's where we take the lesson from the experience, we try to integrate it into our lives by making some sort of shift or change in our lives. And I became fascinated with this. So I started studying it, I began leading the integration circles, I started working with people one on one, I eventually got certified as a psychedelic integration coach. And I've been a full time coach for almost three years now. But it was because it was something that was very helpful to me, you know, I was able to take the experiences that I had, and make some changes and shifts in my life, don't get me to where I am now, which is about 180 degrees from where I was six years ago, is a very angry, impatient person who wasn't very good in relationships, all that's changed for me. So it's a personal passion. And, you know, it is my passion to help pass this on to other people. I think this can be life changing.Ari Gronich 3:48  That's awesome. So, you know, tell me, what's the difference between the recreational use of psilocybin or other psychedelics and the, the therapy side of utilizing these medicines for taking care of emotional trauma and releasing, and so on, because, like you, I was a child doing certain things and and I find that as an adult, those experiences are much richer and greater and create more of a permanent change for me. So talk to us a little bit about the difference between the recreational side and the therapeutic side.Greg Lawrence 4:40  Well, I first want to say that I you know, there are a large part of the psychedelic community that uses the word recreational sort of a pejorative, like that's not the way you're supposed to do it. I don't believe that there should be any shoulds around psychedelic and I realized I use the word should to say that but Once you are safe and responsible, which means that you are not bringing harm to yourself or another person, I think if you want to experience a museum, a movie, some movie, or some food and other person's body nature, whatever you want through the lens of a psychedelic, I think that that's fantastic. People should be free to explore their consciousness in the world in a way that they want. But there is sometimes a thin line between recreational use and intentional use, I'll call it and maybe a little bit thicker line between intentional use and therapeutic use. So unintentional use, we spend a lot of time setting intentions, we try to pay attention to what's going on during the experience, and we try to integrate it afterwards. And therapeutic use, it might go a little bit deeper, we might actually use eyeshades and headphones with carefully curated music, we make sure that the person is prepared ahead of time for the experience, and especially prepared for any possibly disturbing images or memories, or anything that might scare or upset them. Because that's a very important part of the process for them to understand that that is part of the process. And it's something to be experienced, not something to run from. And I would say in therapeutic use when you talk about things like the clinical studies that are going on with places like maps, and in places like NYU, Johns Hopkins, and so forth. There is a significant therapeutic component on each side of each experience. So you will have therapy beforehand, to prepare you sort of explore what's going on with you and see what your issues are a lot of therapy after the experience to help integrate that experience.Ari Gronich 6:35  What about therapy during the experience, that'sGreg Lawrence 6:38  known as psycholytic therapy. And that's not something that's done very much. There are a few places in Europe that do this with MDMA. It's not something that's done much with psychedelics like LSD or psilocybin. They don't really lend themselves to therapy. And really, there is a theory that there's an inner healer within, you know, within you, that knows the issues better than anyone else could try to guess. So sometimes I started with MDMA, but in the vast majority of experiences, people have an internal experience, and then they do the therapy before afterwards. And before.Ari Gronich 7:11  Got it. So one of the things that I utilize in my practice has been psychedelic therapy with bodywork and deep emotional release breathwork. And I've, I've always found that the issues are in the tissues. And when you combine those two things, you can really, really get permanent clearing of the issues that are in the tissues, because you're breathing it out, the body's being moved through it, the places where the traumas are, are being literally touched. So there's like a spotlight on those places. And then the medicine does its work of allowing those things and those traumas to release. Have you ever experienced that or heard of that kindGreg Lawrence 8:10  of work? Yeah, I do energy work myself, I practice personally trauma release exercises. So I realize there is both a psychological and a somatic component to the issues that people are facing. And that trauma is held in the body. So in the work that I do with people in preparing them or helping them to work with these medicines, because what I do is I work with people before and after, as an integration coach, I help prepare them for any experience. And I help them integrate the experience the middle part they do on their own or with someone else. So in my preparation, sometimes I try to determine which mode which would be better for a particular person. Because there is a way from disconnecting from the story in your head, and just experiencing what's happening in your body as issues come up. There is a way of diving deeper into the story in your head to see what kind of resolution you can get. And there's a combination of the two where you can be experiencing something and your body will you know, you can experience the past in your body while you're in the present in your head. So all those can be very helpful. But yeah, there's a significant somatic component. I think, too, especially trauma.Ari Gronich 9:18  Absolutely. I've I think Burning Man was my first experience with psilocybin in a therapeutic healing, you know, manner. And I think I was about 2627 at the time. And we had somebody who couldn't hear out of her ear since she was like five years old, and about a two and a half, three hour session. We were done. She could hear out of her ear. It was really fascinating. And that's what interested me originally in psilocybin and psychedelics as therapeutic healing tools. What about micro dosing? And I know this is becoming especially within like the Silicon Valley crowd, it's becoming a pretty regular thing to do micro dosing of these, these things, what are the effects? What are the side effects? if any? What is it that you're experiencing with a micro dose of a psychedelic?Greg Lawrence 10:27  Well, I just first want to say that micro dosing has exploded outside of Silicon Valley. So I take monitor and take part in a lot of online groups, and a lot of Facebook groups and online forums that are specifically about micro dosing. And there are people coming to these groups every day, dealing with issues like anxiety, depression, OCD, traumatic brain injury, you know, childhood trauma. And these are people who aren't even considering using psychedelics in the classic sense, they just want to take advantage of the effects of micro dosing. And I also want to say that there is scant scientific evidence that micro dosing actually has an effect just because there's been almost no research done on it. It's still in process. But you know, for all we know, a lot of these things are the placebo or placebo effect, if they are fantastic. Yay, placebo, I say. But micro dosing is the consumption of sub perceptual amounts of generally, LSD or psilocybin, people microdose all kinds of substances, but we're generally talking about LSD or psilocybin, when someone says micro dosing, the effects are generally not felt. And that's kind of the idea. You know, psychedelics are sort of a cathartic experience, they do what therapy does, they bring the unconscious to the conscious, so difficult emotional and psychological material surfaces very gradually in therapy, and eventually, we feel kind of crappy, we process these things, and we feel our feelings, we get it out of us. psychedelics want to do this very quickly. Micro dosing does this very gradually in the background, so there's not too much for some people. It's very comparable to taking a nootropic or a smart drug, where you just feel kind of sharp, on together, it's very easy to forget that you've microdose when you're doing classic micro dosing, you might just feel good, I'm just having a great day. And then oh, yeah, I did a micro dose this morning, you might just feel good, better or not as bad. Some people see pretty immediate relief from things like anxiety and depression, symptoms of OCD. And some people you know, conditions like bipolar, usually contraindications for using psychedelics, but people with bipolar disorder, or micro dosing and getting some benefit from it. I want to say that people with those disorders should use caution when they're micro dosing, you should always do always do plenty of research and find out what the risks are. But so far, as far as drugs go, physiologically, psilocybin is one of the safest substances you can take. You know, I've seen a chart when they show the relative safety of different drugs based on things like emergency room visits, 911 calls, psilocybin is at the bottom, it's underneath aspirin and tobacco, it's one of the safest things physiologically that you can take. So taking in minute quantities. So far hasn't been shown to have any ill effects physiologically. Now, micro dosing can do things like bring emotions close to the surface. Some of these things are dose dependent. So some cautions I give people is that if you do a little bit extra, if you go somewhere between a micro dose and a regular dose, you could get stuck in a sort of an uncomfortable space where things are starting to come up. But you never get to that place where they start processing. So you can just be sort of jittery, anxious, nervous, sweaty, just uncomfortable in general, emotions can be close to the surface. So in these forums, I regularly see people saying things like, you know, expected micro dosing to be sort of calming to me, but I find that I'm very irritable, I'm crying for no reason, I'm angry at my children having trouble controlling myself. I'm sweating a lot. I'm not comfortable, I'm not sleeping, I'm too tired. Many of the times I see these things are dose dependent, people are just taking too much. So it's generally advisable to take about one 10th of a normal dose that is, in general, somewhere around 10 micrograms of LSD, although people do less or more, and it's somewhere around 100 or 200 milligrams of psilocybin, although people do less or more, it's got a lot to do with tolerance, your specific conditions, your environment, etc. There's no standard microdose just like there's no standard dose of psychedelics,Ari Gronich 14:35  right, is it is this kind of a medicine weight reliance, like if somebody is heavier or lighter, or does that not matter muchGreg Lawrence 14:47  psychedelics have very little to do with body mass, weight, height, etc. They're sort of like psychotropic drugs like antidepressants. There's a standard dosage but you know, three grams of mushrooms can really send a 300 pound person into the sky and do nothing for 100 pound person depends on the person's receptors, their own tolerance, etc.Ari Gronich 15:09  Okay, so what is the chemistry that happens in your brain when you are micro dosing and when you're macro dosing,Greg Lawrence 15:17  micro dosing, we don't have as much evidence about exactly what happens when you take the medicine. But for a standard dose of say serotonergic, psychedelics, LSD, psilocybin, mescaline. They are serotonin agonists. So they will latch on to your serotonin receptors. serotonin is known as the feel good neurotransmitter, it's the feel good chemical. These substances don't release more serotonin into your system, they just kind of mimic serotonin. Once they grab onto that receptor and start mimicking serotonin, what happens on the other side is not exactly clear, physiologically. There are a lot of technical things that happen. What basically happens though, is that difficult things start to try to come to the surface for you sort of the opposite of the action of an antidepressant antidepressant takes those difficult feelings and tries to just push them down here, so you don't have to deal with them. psychedelics do the opposite. We try to bring them to the surface so that you'll experience them process them.Ari Gronich 16:17  So it sounds like it's basically turning the light into the dark, you know, like you put a flashlight in where you've been dark. And so all of a sudden, you can see what is going on and spotlight itGreg Lawrence 16:30  correct. Yeah, psychedelics are what are called nonspecific amplifiers of consciousness. So what will often happen is something that is bothering you that you've been suppressing something you didn't realize was important to you. Something that is a problem for you that you've been ignoring, will come to the surface. I'll give you a perfect example of this. young man who who called me he had had a difficult journey on mushrooms. And the following happened to him. He grew up in a small town in the Midwest at the same friends all of his life, went through grade school all the way through high school with them. good looking guy, very athletic, very popular, always had girlfriends ton of friends. He said he never had to try too hard to do anything. The major he wanted to take in college was different than that of his friends. So he ended up going out of state where he knew nobody. Suddenly the guy is 19. And he has no friends and no prospects and doesn't know what to do. He realizes I've never had to make friends from scratch. It just always has been there. And he's kind of lonely and a little bit desperate. Luckily, he finds these three guys were just great. he clicks with them immediately. They like to joke around with him. They include him as part of their gang. And he's hanging out with these guys for a couple of weeks. And they say, Hey, we're going to go to the forest and do mushrooms this weekend, would you like to go? He says, Yeah, I'd like that. He's been hearing about this, he wants to try it. They go to the forest, they find a spot, they take the mushrooms. And about 45 minutes later, while they're all talking, this guy realized this, these are terrible people. They're not joking around with me, they're insulting me and where I'm from. They're racist or misogynist. They're just not the kind of people I want to be with at all. So he spent about three hours being around these people who made him feel very unsafe. That was the bad experience he had. But that just shows you what happens in our everyday consciousness. There are things that bother us every day that we just sort of put to the side, we take these substances, and it says, Hey, this thing is bothering you, you really need to look at it. Because everything looks fine on the surface. But there's a feeling in us that something's just not right, that might be might manifest as anxiety, depression, just a feeling of unease. Being stuck having to deal with procrastination, maybe I'm not getting along in my relationships with people. These all cause issues, but they're things that we're suppressing and putting in the background. psychedelics will bring those things into light for us, as you say.Unknown Speaker 18:55  Awesome. SoAri Gronich 18:57  let's, uh, you know, you're talking about college. So I have kids in college. They obviously have had experiences the kids that I know, with, with psychedelics, with other kinds of things. But as an as a college student, who's experimenting with their minds, what are the precautions other than, like, you kind of brought it up with making sure that the space and the people you're with are safe for you, but what are the other kinds of precautions that you would give to kids that are attempting to experiment with these things and may or may not really know the power of them?Greg Lawrence 19:46  Yeah, firstly, I would say that although I am what I would consider to be a psychedelic advocate psychedelics are not for everyone. So I would advise anyone to do their research and find out if they have any psychological, medical or physical contrary indication. Because they don't work for everyone. if they have any significant psychological issues, they might want to also look up a therapist in case anything difficult comes up so they can work that out with them afterwards, you definitely want to pay attention to a separate setting. So set is my psychological set, how I'm feeling, how things are going for me what kind of problems Am I might have right now. And setting is my physical studying, including the people around me. Now I said psychedelics are amplifiers. If you are going to do psychedelics, if you're going to be around someone that you don't like, just be aware of the fact that that's going to be amplified for you. And that might make things make things very difficult, should always be comfortable with the people you're going to do psychedelics with, if you're going to do them with other people, I would say that you should do them with at least a sitter, if you have not experienced these substances before, in case you need assistance in some way.Ari Gronich 20:55  Kind of like my driver.Greg Lawrence 20:57  I'm sorry, whatAri Gronich 20:58  kind of like a designated driver.Greg Lawrence 21:00  Yeah, should be someone who has experience with psychedelics, preferably, so that they understand what you're going through, who knows what to do and what not to do. Because once having a difficult time, sometimes it should be talked through it and not down or out of it. Sometimes people have to process something. So telling someone that a difficult memory wasn't that bad is not what you should be doing. When something's going on, someone's going through that experience, holding their hand, getting them some water, keeping them safe, all allowable things, but don't try to characterize their experience. But you just want someone who's going to be there in case you need help in some way. And I would also say that intention setting is very important. You know, you don't go in trying to control the experience. But do do think you do think at a very high level. What is it? I'm trying to get from this experience? Where am I going? What am I wanting? Okay, soAri Gronich 21:49  what you're saying, what I'm hearing, is that you want to be really cognizant of what it is that you're doing. And make sure you've researched enough. Make sure that you have somebody here somebody in your space that's safe, and somebody that's in your space that is already done what you're about to do so that you have a guide,Unknown Speaker 22:24  basically,Greg Lawrence 22:24  correct. Yeah, rather than a guide, I would say someone just to be there to make sure that you're safe.Ari Gronich 22:30  Okay. So Iosco is a little bit different you have to have kind of a guide, right? Have you had any experience with Iowa SCA and and what's your take on kind of the differences between the twoGreg Lawrence 22:46  you know, psychedelics end up taking you to sort of the same place in a different way, you know, it's getting to the same location or different vehicle, I have lost could can have a very heavy body load. Meaning I feel it in my body that often causes people to purge in one way or another that made through faith through vomiting, diarrhea, sweating, crying, what have you, but I watched it can be a very difficult experience to have a very difficult substance to work with. But also all the psychedelics can is generally done like you said, in a group setting, under the supervision of a shaman or a facilitator. shaman tends to be an indigenous person who has a lineage she's learned from facilitator, someone who's learned how to work with the medicine. And they generally there's generally live music played in the form of Ikaros. Those are songs that were written by Alaska for I Alaska that have a lot of power can help guide the music through your body or help get you through difficult situations. So I mean, my cautions would be the same as they would with any other psychedelic, make sure it's for you. And there are some physiological considerations with Iosco too. There are certain foods you shouldn't be eating and certain medications you can't be taking before you do Iosco that should all be given to you by a facilitator or shaman before you ever sit with the medicine.Ari Gronich 24:09  Right? me what I guess what I was trying to get two was the chemical difference. I know Iosco is being used quite a lot in some places to get people clean off of heroin and opioids. And so I was just trying to draw out some of the chemical differences between what happens in your brain for when you know, with these different substances, because each one they take you to fairly similar places. However, the chemical storm that happens in your brain might be a little bit shifted.Greg Lawrence 24:48  You know, I uh, wasco is a combination of DMT, a DMT, containing plant dimethyltryptamine and an MA o inhibitor because there's an enzyme in your called mono amine oxidize, and that will kill certain things to keep it from getting into your body, including DMT. So when you take an MA o inhibitor, it allows the DMT to be metabolized by your body. So chemically, it's probably a little bit different, but how it works psychologically, what it does, once you get in you is different for every person. You know, we all have defenses built up against words. So if I don't think that I am deserving of love, literally everyone around me until they tell me that I am, but it just doesn't get through. So psychedelics will do some very novel and unusual things with us, they might play games or simulations, they might make us feel a certain way provoke emotions in us, they might show us stories or metaphors, or myths of some kind. They may show us our own lives from a detached perspective, but they'll do a lot of things to get messages through to us that we wouldn't get otherwise. So what happens when you take a psychedelic of any kind is different for every person every time they take it?Unknown Speaker 26:02  Absolutely. SoAri Gronich 26:04  let's go through some of the different psychedelics and what what you might want to take each one for, like, I know this big trend and combo are frog medicine. You know, you have pod masculine, you know, LSD, MDMA, to CB, the Alexander Shogun medicines. So what is it that each one like if you were to have a menu item, you know, you go into a restaurant and you have menu, and it you know, has all the different kinds and then it would have a description on the, you know, the thing that you might want to take this one for versus this one versus that one.Greg Lawrence 26:50  I don't like assigning a purpose, except that I will say that there is you mentioned, heroin and opioid addiction. So there's a substance called Ibogaine. This is the active ingredient and a root bark from West Africa called Iboga. It's an extremely powerful psychedelic, it may leave someone basically immobilized for 24 to 36 hours. It's very hard on the heart and the liver, people actually have to have an EKG and a liver panel done before they undergo this treatment. But Ibogaine has been shown to be very effective in addressing opioid and heroin addiction, because it goes into resets the receptors and it sort of takes you through a journey that lets you see what happened to get you where you are. And it usually almost eliminates or completely eliminates any desire to the substance once you come out. So that is a very powerful substance that is used for psycho spiritual purposes and in addition to be using for addiction, but it's a very powerful and sometimes dangerous substance, there have been hundreds of deaths from people who should not have been taking that substance due to something like a cardiac condition or medication they were taking or some sort of drug that they were on that they shouldn't have been at the time. There is a substance called Five m e o DMT. That is a substance that is a short acting, you know, 15 to 45 minutes, but in a sufficient dose it it produces an instantaneous ego death. So, the thing that makes me think that I am Greg and not a part of the universe sort of disappears for a while not become one with everything. There is also a danger sometimes of doing too much of that substance, people can become ungrounded unbalanced and, you know, a lot of integration and a lot of care afterwards, you know, having your world sort of taken apart in front of you and then put back together can be difficult to times. I would say the facilitation is key in that you should always work with the skilled experienced facilitator when working with that substance.Ari Gronich 28:51  There is in in DMTGreg Lawrence 28:53  that is another short acting rapid onset psychedelic that you think through vaporizing through smoking basically, and works instantaneously for anywhere from 15 to 45 minutes, and is highly visual and psychedelic. People have reported things like talking to entities or entering into other universes living other lifetimes to very powerful substance. Then I would sort of stack in the classic psychedelics. Oh, excuse me, I should mention MDMA. MDMA is sort of methamphetamine. But it's an pathogen. It's a heart opener. It's what's being used in the in the studies for clinical treatment resistant PTSD for veterans by maps, the multidisciplinary Association for psychological for scientific studies, excuse me, psychedelic studies. Sometimes when people have severe p. e, it's hard for them to even talk about what happened to them without being thrown back into the event. Under the influence of MDMA, MDMA, people are actually able to view their trauma with their fight or flight response. Once down, it slows down the amygdala, lets you see your trauma back then. And you hear and understand that that was then and this is now in your safe now. And helps people rapidly get to the point where they can start working with therapists on the issue once they've spoken about it.Ari Gronich 30:14  So let's say someone that I would, sorry, let's say somebody was, somebody had been sexually abused, right? When they were a child. And now they're, they're experiencing relationship issues and things and, you know, they, they feel like they've gotten over that experience that doesn't necessarily trigger them, they can talk about it, and so on and so forth. But then, they still are having relationship issues, is that something that might be of support for somebody who's experiencing that kind of a trauma over and over and over again, in their minds?Greg Lawrence 30:58  Well, I do want to point out that all of these studies, for instance, with maps, these are called MDMA, it's called MDMA assisted psychotherapy. So it's never a therapy assisted psychedelics and psychedelic assisted therapy, the therapy is a very important component, someone with the kind of issues that you're describing might benefit from working with a coach or a psychotherapist, but certainly a substance like MDMA, or a substance like a classic psychedelic of LSD or psilocybin, something like that could be useful to someone if they're prepared to use it in an intentional way. And sometimes they don't even have to be prepared to use an intention away, sometimes things come to you and those experiences, but it's very important. Once again, to integrate those experiences afterwards, I can be shown the exact moment when my trauma was born, that doesn't necessarily do anything for me to resolve that trauma that doesn't fix the patterns that are resulting from that.Unknown Speaker 31:54  So what doesGreg Lawrence 31:56  psychotherapy does, you know, I work with a combination of I'm not a therapist, I'm a coach, but I work with cognitive behavioral therapy, neuro linguistic programming, and a number of personal and spiritual development disciplines to help people break patterns to make changes in their lives to basically have choices. You know, when something happens to us, we tend to dig a very deep neural pathway that says, This is what I'm going to do when this happens to me, I'm going this way, it just becomes automatic after a while, it's like putting on a seatbelt in the car, you don't think about it anymore. It's just what happens. What we have to do is use the same mechanism that Doug that grew to dig another group, so at least you have some choice sometimes, so that you are more mindful and aware of what you are doing. So that you have another choice besides the automatic choice that used to happen all the time.Ari Gronich 32:43  All right, so do we know if those neural pathways actually atrophy or if they, the trauma, neural pathway atrophies if you create the other, the other?Greg Lawrence 32:56  You know, one of the things that happens in the aftermath of a psychedelic experience is called neuroplasticity, that is the ability to easily form new neural pathways, new habits, patterns, new ways of thinking, being and doing. So if you can take advantage of those and you start using those new neural pathways, yes, after a while the other ones sort of fade and well, sort of atrophy. They're not guaranteed to go away. But that is something that happens in that process.Ari Gronich 33:22  Gotcha. So do you think that it's, I know, you're an advocate. But let's say there's a lot of trauma obviously, going on in the world right now. And, you know, my personal belief is that if more people were to experiment with these kinds of ways of doing therapy, we'd have a lot less problems and a lot more understanding and love and care for, you know, our communities, because we'll have a much broader perspective. So I know it's starting to get a little more mainstream to legalize in some of the liberal states. But you know, what, what is? What is the reason why we would want psychedelics to remain illegal? Because there's got to be at least one reason. And then what are the reasons that making them legal, are going to be beneficial? And then the last part of that is, should the legality be therapeutic only or should it be a combination of recreational and medical?Greg Lawrence 34:42  Well, there is an answer to one of your questions in your question, and that is, what is the problem with them becoming legal? The problem that some people have with them becoming legal is that they are sometimes and so let's take the map studies. If the map the map studies are in phase three, now clinical excuse Using MDMA assisted therapy to treat treatment resistant PTSD. Now, if those studies go well, in phase three, this could be a prescribed herbal treatment in 2021, or 2022. When that happens, that means that MDMA will be available by prescription in a very lengthy protocol, that's probably going to cost somewhere between 15 and $20,000 per round of treatment. Okay, so now we have MDMA, sort of in the public domain, but still not available to me. I'm a very strong believer in cognitive liberty. There is no truth to the assertion that psychedelics have no medical value, that they are highly prone to abuse and all the other reasons that were given to make them schedule one. They were made schedule one for various reasons, but not for the reasons that were stated by the government. I personally believe one of the very big reasons they were taken out of the public domain is because people were walking off the battlefield in Vietnam. In a country that is built on consumerism, a country that is built on capitalism has to have an operating army, and can't have people on mass saying, I am not going to a foreign country to kill people for you. That's one reason they were taken out of the public domain. So I believe in cognitive liberty, I believe that these substances that do not harm me should be available, available to me, with all the usual precautions, and so forth. I mean, the things that I can go and buy right now from a store, I can buy alcohol, as much as I would like to drink myself into a stupor and kill myself with it. It's almost impossible to do that with psychedelics, but those are not available to me. So, this is one problem that people have with legalization as legalization sometimes leads to medicalization, I can get these to a doctor, I can get them through an authority, I can get them through an intermediary. Mushrooms grow in the ground, no one should be able to come between me and a substance that grows on the ground. That helps me to explore my own consciousness. That's my belief. Okay, next part of that question. Next part was, what is the problem with legalization you asked? Right, butAri Gronich 37:10  the medical versus recreational? So I'm asking I get your belief. But I'm asking what are the reasons to go against that belief that you have what what is what is the excuse? What is the reason for keeping that substance away? IsGreg Lawrence 37:31  there a do want me to take the counter position?Ari Gronich 37:33  Is there Yes, I do. Is there a danger of having a psychological break? This is some of the fears that people are having. So yes, I want you to take a contra position to your own position.Greg Lawrence 37:45  The counter position is that psychologically, that psychedelics should be used with caution, they are not for everyone, everyone is not going to be prepared to use them. And things like bad trips usually come from people who shouldn't be taking psychedelics, who has some sort of contrary indication, we're not properly prepared for that experience. They can unbalance people, they can throw them into a state of unease, and they can bring up latent mental illness people. Someone with dormant psychosis can have that activated by a psychedelic experience. So yes, there should be caution education and a big wrapper of harm reduction around these substances.Ari Gronich 38:23  So basically, what I'm hearing is that any of the reasons why you would not want to do something, are for the reason of safety. And most of that safety can be alleviated with education.Greg Lawrence 38:45  I believe that, but I also believe that there's nothing that's forever. So I hear memes, like, you know, all politicians need to take LSD or cops need to do a walk or something like that. That's not how it works. These things are amplifiers of consciousness and of ego. So there are plenty of racist and nationalist who takes psychedelics and it strengthens their worldview. It doesn't automatically fix everything for us. Someone has to want to heal, they have have got to have a desire to change. If you want them to change the use of these substances, they don't automatically change people for the better. There are plenty of people who have their ego strengthened through the use of psychedelics. So they're definitely not a panacea. They're not for everyone. They should not be used universally. Some people just aren't going to like the experience. Some people don't wish to be introspective. Some people like themselves the way they are and they don't want to change or feel that they need to. So these are for people who believe that they might work for them. Okay,Ari Gronich 39:44  so the next question becomes what age should somebody start the process of experimenting? Because I know a lot of kids 16 should do you know 14 1516 in high school, They experiment, yet their brains are not fully developed yet. Is there damage that can be done for the young, developed brain? Or is that just a thing that we can ignore as long as they have the education of what it's for?Greg Lawrence 40:17  Well, I don't think it's a thing we can ignore him. We're a society that already puts age limits on certain substances and certain activities. So I don't think we can just take something that is a as potentially powerful as a psychedelic and take the brakes off of it. I think you're correct, that brains are not fully formed until someone's in their early 20s. Now I'm going against my own experience. I was doing psychedelics when I was 1617 years old, I believe I benefited from that. But since I've already done that, I don't have to prove anymore. No, actually, I would say that there's no definitive proof that there is harm to a person from doing psychedelics of a certain age. But there's no proof that there's not, we don't know what we don't know. So if I were to personally have to make the rules, I would say I would exercise caution in that area. Exactly where I draw that line, it's hard to say,Ari Gronich 41:07  okay, so do you think that your early childhood use of the psychedelics was a gateway to the harder drugs that you started to take afterwards? No, IGreg Lawrence 41:17  think that my trauma was a gateway to the harder drugs I started taking afterwards. And was probably one of the more sensible things that I did, you know, the drugs that I did later on helped me escape from reality. psychedelics helped to illuminate my reality. And for all I know, maybe the fact that I was doing psychedelics, becoming more aware of my issues, and not working through them, sort of tipped me into an area where I wanted to use other drugs. I have no idea.Ari Gronich 41:42  So I said, I want to play this out, because I, you know, the contrary. And the reasons for are as important, each thing is as important, right. So one of the issues that people have with marijuana is they think that it's a gateway drug. I believe that trauma, as you said, is the gateway to all bad behavior in general, trauma equals bad behavior, trauma, this trauma, that trauma and needs really, are the things that lead to the bad behavior, bad, bad results. So that's where the question comes in, is, I want to, I want both sides of the subject to be illuminated, so that if people decide I don't want this show to be a deciding factor for them, to either try or not try, right, I want them to have as much information as possible. But let me ask you this question. Because, you know, we're going through this amazing year. And I believe that, well, there's there's a lot of suicides that are happening, a lot of domestic violence that's happening, a lot of alcohol abuse that's happening during this quarantining and isolating, and I believe that psychedelics would help people who are faced with this isolation and looking for a reason to illuminate their, their traumas, because a lot of people are sitting in their trauma, and not really able to express it outwards, because they're just sitting there isolated and alone. So yeah, that's, that's what I where I want to go with that question.Greg Lawrence 43:40  Well, I would say that there are two sides to that coin. Definitely. So let's say in this, do you have people who are lonely who may not be in an ideal relationship? Um, if I become aware of the fact that there's not an ideal relationship, if that surface, if that is that is spotlighted for me through the psychedelic experience. Now, where am I? I'm not happy in the relationship. I'm going to have to go and be isolated somewhere I've sort of stuck I have limited choices right now. Same thing for someone in an abusive relationship. What do I do now? Now I'm in this time now, and then this restricted time, and I sort of stuck in this relationship. And that's been illuminated for me. I think people have more trouble now getting support for issues that may come up. So yeah, psychedelics may help some people in these situations, they may not be especially helpful in this time when people were restricted, locked down, and sort of stuck in certain situations with limited choices, and limited assistance. I think that's key always with psychedelic experience. Having some having some assistance beforehand, and afterwards, I think is key. That's where everything gets worked out. You can have things shown to you, and you can understand that something's a problem. And you can understand where your trauma came from. All these things can be perfectly obvious to you. But that doesn't change the fact that you we're reacting to what's happening in front of you based on past events. You know, changing those patterns and undoing those triggers is key to that.Ari Gronich 45:09  You know, it's interesting when I was dealing with detoxifying, I have a brain tumor that I've had since I was about seven years old, at least symptom wise, probably since I was born. It's a pituitary tumor. And it triggers all kinds of hormone imbalances and chemical imbalances in my, in my body. And so I was going through a detoxification, I lost about 140 pounds during that detox, even though doctors told me that I would never lose weight. And I would, at home, basically, take a dose of mushrooms, and then put on hypnosis, videos and brain training videos and things that are uplifting. I'd listened to Jim Rohn. And, you know, Les Brown and Tony Robbins while I was in those situations, and, and then I would have whatever explosion in a mirror that I would have for two or three hours of crying and staring in the mirror. And then I'd go back to Okay, let me integrate that a little bit. You know, it was it was an interesting experiment. Because typically, I've, I've not done that as a loan. Alone, you know, medicine, I haven't done the medicine alone. I've been in a group with a therapy, or I've done the therapy on people, but I haven't been in that process of doing it alone. I'm not sure that I would recommend it, but because it is really powerful and, and difficult. And I probably would have preferred to have had a guide or a, you know, somebody there with me that that was making sure I was okay. But, you know, what, what's your take on doing psychedelics alone. Other than microdoseGreg Lawrence 47:21  That's true. I think most of the time when I do psychedelics, I do them alone. You know, there are ceremonial settings where there are other people around, but you know, I often do them alone. I'm used to them, I know their effects. I know all the safety protocols, losing my headphone here. And I will often work with music, I'll listen to something inspirational or something educational, or listen to binary old beats, or solfeggio tones or something like that. So yeah, I do about the same thing. I'll work through my issue. Sometimes it's more fun, sometimes it's more work. But once you know how you're going to react, once you know that you're safe at a certain level, once you're aware of all the risks, and so forth, once you know how to prepare and how to integrate, then, you know, I think working alone is great. And I usually caution people, if you're going to do psychedelics with people, make sure you know who the people are in your comfort level with them. Otherwise, you're going to be projecting things outward, that is going to distract you the whole time, and can make it a very unpleasant experience.Ari Gronich 48:23  So what happens when something comes up, that's really, really hard to process and you're alone in in that,Greg Lawrence 48:30  for me personally, or for someone else,Ari Gronich 48:33  for anybody, if they're in that position of I'm doing this alone, and I'm listening to these things, and then something pops in or comes up that is just like really, really, really hard to handle that it would be nice to have somebody there to help you go through it. Is that where you where you would say, time to call me kind of thing.Greg Lawrence 49:03  Someone can do that. But I would certainly prepare someone beforehand by telling them that there is nothing that happens in the psychedelic experience that happens for any other reason than for your healing. So something difficult may come up. And if it feels like it's too much, that's just your brain telling you that it's too much. The only thing that's going to happen is there's going to be a feeling in your body and a story in your head. That's all that's going to happen. And if it's really, really bad, there's a good chance that you're pushing it away or resisting it. You know, fear of pain is often much worse than the pain would ever be. So what happens is we have a painful experience, most of the time in childhood or when we're small. And then our brainstem center protects us and says you need to stay away from them. That's very, very scary, you know, for for better or worse, our brains think would be a very bad idea for us to change. So they protect these traumas very strongly. And they put all Have guards around them. Sometimes those guards are scary feelings, like it feels like if I start getting angry, if I start getting sad, I'm just going to be carried away somewhere, it's too much. The best thing you can possibly do when it feels like you can't possibly surrender to something that happens in the psychedelic experience is to surrender to it, to let go and to fall into it, you probably didn't take too much, you probably won't be stuck where you are, you're not going to die, you're not going to start stop breathing, you're not going to go crazy. Those are all things your mind wants to tell, might want to tell you to keep you away from this scary thing. But that scary thing is what's haunting you from the inside. It's the reason that you're looking for an answer, it's a reason things don't seem quite right to you. Like there's something that needs to be fixed, why there's just something wrong with me, and I just don't fit in somehow. And I'm always going to be a little bit deficient somehow. Those are the things causing these feelings on us. So there is no such thing as a wrong thought, emotion, memory or image. They can't be wrong, they can't kill you, they can be experienced, one of the best things you can do is feel the feelings that come up. We don't like to be mad, and we don't like to be sad. We have reflexes built up to tell us not to feel these things at any cost. Sometimes, this is what's happening when something very disturbing comes up in the psychedelic experience.Ari Gronich 51:27  So are there any good techniques? So say somebody is alone and and in their? in their journey? And something comes up? Are there any techniques that they can do in order to calm that down? or express it more so that it can be integrated and released? Or is that just an after session kind of thing?Greg Lawrence 51:57  No, I think beforehand, one of the best things you can do is to build a strong mindfulness meditation practice, where you are observing what is happening in your body and in your head. While it's happening while not being attached to it. build up a strength practice like this. And pretty soon you can be watching the changes and shifts and emotions of all kinds that happen to you, without guarding against them, or thinking there's something wrong with them. This in the psychedelic experience can be valuable, because then you can observe a feeling of terror in your body and realize it's just a feeling in your body. That's human emotions, our emotions are stories tied to feelings in our bodies. So if I can get to a place of just experiencing what's going into my body, and realizing there's a story in my head that I don't have to climb into that thought it can be there and it can be okay. But I don't have to be that thought in the moment. That can be very helpful. Saving, save that I would say, breathe deeply, and relax and realize that you're going to be okay. This is happening for you. It's happening for a reason. And you're going to be okay, you're actually resolving something from the past. Breathe deeply and relax and remember that you're going to be okay. And this is going to be over soon. You know, it's like you're going through a tunnel, it may seem dark, but there's light just up the head. Just hang on, you'll be fine.Ari Gronich 53:20  Awesome. So, in, in conclusion, what are the things like the top five things that you want people to get about this medicine or these medicines and how they can be usedGreg Lawrence 53:40  for your good psychedelics can help us enjoy the world. And they can help us realize that really, for the most part, nothing's wrong. What's wrong is the way that we're thinking about things in our head. I mean, that's a common occurrence that people have. It's one of the deepest experiences I ever had was realizing at a very deep level, that right now nothing's wrong. I might feel like I need to do something or something needs to change or something needs to be adjusted. But that's just something that I've got, I have the impression of that's something that happens to me. But right now, nothing's wrong. So they can help us with things like radical acceptance. With realizing that right now, no matter how I feel, the feeling is okay. The problem is when I say Oh, shit, I feel that way. having anxiety is not a big deal. But as soon as I say, Oh my god, how do I get rid of this anxiety? Now I have a problem. Because I'm not feeling the anxiety. I'm not processing my feelings. I'm compounding with these things. I'm creating a neurosis. I'm making levels here. So I try to accept the anxiety if I can't, maybe I think there's a problem. I think I think maybe I can accept the fact that there's a problem with the anxiety. If I can accept that. Maybe I can accept the fact that I can't accept that. It's a process people should be prepared when they start to work with psychedelics, and they shouldn't be prepared to work with them material that comes up afterwards. Now I tend to overconfident about these things, someone might listen to me and say, Oh my God, I've been able a psychological material come up, it's going to be difficult, going to be scared, and then have the most beautiful experience of their life. That's also an option. I'm just here to caution because I think people are under caution. And they hear things like there's no such thing as a bad trip. So I want them to understand that if this happens during your journey, it's not a mistake. It's one of the things that happens to feature on a bug. With micro dosing, I'd like people to know that a lot of the side effects are unpleasant effects that they feel are sometimes dose dependent. So maybe look at your dose, there's a lot of misinformation online about taking as much as you can, or you're supposed to work through your anxiety or do some sort of breathing or listen to binaural beats to calm down. But really, you don't have to feel that way. You don't have to feel the dose microdosing is in the background.Ari Gronich 55:58  societal effects. So what do you think that the benefit to society itself is when people begin to experiment more and heal their traumas more from using psychedelics?Greg Lawrence 56:21  Well, I think it's very much like when people start down a path of personal or spiritual development. So there are two theories, I think you could say about when people start down that path. One is that I have 57 problems. And next week, I have 52. And a few weeks, I have 48. And then I have 37. And pretty soon I have 28 problems. And nothing outside of me has changed. All this changes my perception of what is a problem when I'm making a problem. Now, the other theory is that I still have those 57 problems, it's just not a problem that I have them anymore. But I would say the societal effect is that I stopped perceiving that I have so many problems, Rahm das said, the only thing that I can do for you is work on myself, the only thing that you can do for me is work on yourself. So when I have less problems, and you have less problems, there are two things that happen. The first thing is that there are less problems in the world. Now you and I each have you have 28, and I have 35. But there's not 114 anymore, so there are less problems in the world. The other thing that happens is now I know what kind of things I might want to address, because if I have 57 problems, and I go out trying to solve all of those, I'm trying to solve Phantom problems in there somewhere. I'm trying to solve something that just seems like a problem to me. The more I can cut that down, the more I can focus on what might be real problems outside of myself, what things what kind of things I might want to see change, what kind of things I might want to contribute to what kind of world I want to see. That's the societal. The major one.Ari Gronich 57:54  Very cool, very cool. So at the end of my interviews, I always ask the same question. And that's three to four tips, tricks, actionable steps that somebody can take immediately to create a new tomorrow today for themselves and activate their vision for a better world.Greg Lawrence 58:15  There are two that I would give. One is to be more mindful whenever possible. So think about what you are doing as much as possible and don't be on autopilot. Move the trash can put your keys in a different place, park your car somewhere else take a different route, when you go to the store, do anything you can to wake yourself up, brush your teeth with your non dominant hand, change your habits stop doing things the same way you've always done them because it has you on autopilot, and you are responding to your environment in a particular way, rather than thinking about what you're doing. The second is to cultivate an understanding of the fact that it's okay to feel your feelings that there is no such thing as a wrong thought or emotion. There is no such thing as a wrong thought or emotion. You don't have to act on them. But the fact that you're angry, the fact that you feel hatred towards someone, the fact that you are ashamed of something, all of those things are perfectly welcome. And they will resolve themselves. Trying not to resolve them is what keeps them in us and keeps us tied up. So learning to be mindful, feeling our feelings. untangle both of those things together a good mindfulness meditation practice would be very helpful.Ari Gronich 59:30  That's awesome. Yeah, sometimes I'll play ping pong left handed just to shift my my energy especially when i get i do i do that with tennis also, just when i when i get stuck in that rut, you know of playing and I'm, all of a sudden I'm in this perpetual motion of not doing what I know to do. I'll switch just to reset myself. SoUnknown Speaker 59:55  I love that.Ari Gronich 59:56  I also like you know, writing with both hands At the same time, or getting hands to write with the opposite hand, works the other side of your brain. And those are all very good things. And I never thought of really trying to do that while while in a psychedelic journey, but that might be an interesting experiment, as well as is switching hands while in the journey, because that would trigger that other side of the brain that's maybe been non active or less active or deactivated. So it'd be an interesting experiment as well switch sides and see how well you write with the opposite side. You know, while in that in that space, because maybe cut girl for you,Greg Lawrence 1:00:51  I'd never thought of that. I definitely write better women psychedelics for some reason. My writings more legible. Is it is it? Yeah,Ari Gronich 1:00:59  I have doctor writing so. So you can, I can hardly read my own writing. When I get into doctor mode, and I'm filling out, you know, forms and things like that. But that's it. It's just an interesting thought that that you popped in my head was okay, so what if we switched hands? while experiencing that? Are we going to sweat? Because we're switching sides of brains? When we switch hands? Do we switch thoughts? Do we switch experiences? Do we switch to the things that we're not that are not in that automatic experience of life? You know,Unknown Speaker 1:01:37  I like that,Ari Gronich 1:01:37  how many people here in the audience have have experienced driving somewhere, and all of a sudden, you're on your way to work, but you were going somewhere else. But just that automatic response of I go this way, and I go to work, and all of a sudden you're like, Oh, wait, that's not where I was going? IGreg Lawrence 1:01:57  gotta go, sir. Yeah, or driving for two hours and realize you don't remember it? one bit of driving?Ari Gronich 1:02:04  Yeah, I always I, I've had that experience. I had that experience. Actually, once. When I did a vision quest, I was up on the mountain for four days, no food, no water, sweat lodges on both sides of the sweat. So I was completely dehydrated, and completely into that spirit world. And when I was driving back, I was up in the mountains of Ohio, going back into LA. And if you can imagine the mountains of Ohio, very rural kind of environment, and then you get on the freeway going to LA and it's a very different experience. And it felt to me like I was not driving at all, it felt like I was in the middle of a video game. And everything was coming towards me instead of me going forward. It was really fascinating. And then I was like, how did I? I'm like, I'm almost home. How did I get here? interesting experience. But yeah, I like it. Well, thank you, you know, so much for being on Greg. Is there anything? If anybody wants to get a hold of you? How did they get ahold of you? They want to experience or, or just learn more about this, this adventure of plant medicines.Greg Lawrence 1:03:22  And you can find me at psychedelicintegrationspecialists.com And on Facebook. I'm psychedelic integration specialists. And you can always reach me at Greg@psychedelicintegrationspecialists.com. It's a lot of typing, but it works. Awesome. ThankAri Gronich 1:03:35  you so much for being here. I really appreciate you coming on. And, you know, this is a controversial subject. And it's not something that I actually took lightly when I decided to invite Greg on, I wanted to give you a perspective of what's possible in the world, when we stopped closing our minds and start opening them up to those to those possibilities, and very cautiously and very safely and with a lot of education and research. And I just I wanted I was I was just very sure that I wanted to have Greg on here because I wanted this perspective to to make it to the audience. So thank you so much for being here, Greg. I appreciate you. Remember, we're creating a new tomorrow today, take some actionable steps. Hopefully you have gotten a lot out of this episode. My name is Ari Gronich. I'm your host remember to LIKE subscribe, review rate comments, we want to start conversations about these things. And you know, just expand on the knowledge and expand on the shift. So let's create a new tomorrow today. And I'm your host, Ari Gronich, thank you so

This week on the Renaissance of Men Podcast, I interview the host of the Universe Within Podcast, Jason Grechanik. Jason is a facilitator at the acclaimed Peruvian ayahuasca healing center The Temple of the Way of Light, which is where we met in 2016. Jason also leads his own tobacco healing ceremonies in Peru's Sacred Valley and is an experienced martial artist and yoga practitioner. Naturally we had a lot to talk about. In our engaging three-hour conversation, we discuss: Jason's background, and how he arrived at the Temple of the Way of Light and why he stayed The nature of ayahuasca: what it means, where it comes from, and how best to prepare Being, Identity, and Meaning, and how they combine to produce our experience of reality, as individuals and a species Why it's important to avoid expectations when encountering ayahuasca, and how every person's journey will be unique Personal responsibility when it comes to healing traumas from our lives and our families The fascinating nature of plants, and how many familiar plants embody powerful healing potential   I planned this episode as a gift to the many men I've met that have sincere questions about ayahuasca and the idea of gnosis, or direct spiritual knowledge. But the conversation actually became a gift to me as I got to partake in Jason's wisdom and perspective. Doing so helped me relive some special times in my life, which I look forward to sharing someday. To learn more about the Temple of the Way of Light, click here. To check out The Universe Within, visit the following links: YOUTUBE — INSTAGRAM — APPLE PODCASTS — SPOTIFY To learn more about Jason's tobacco healing ceremonies in Peru, click here To purchase to the full album of Ikaros from the Temple maestros, click here To read Jed McKenna's book "Spiritual Enlightenment: The Damnedest Thing" click here Visit https://renofmen.com to sign up to be notified about exciting upcoming news. Connect with us on Instagram and Twitter.

På sin venstre skulder havde Carstens stedsøn, Raph tatoveret en Ikaros-vinge, inspireret af den græske myte om drengen Ikaros, der flyver for tæt på solen, brænder vingerne, falder ned og dør. Spørgsmålet er om menneskeheden også er fløjet for tæt på, eller om vi stadig kan nå at lime vingerne fast. Tilrettelæggelse og indtaling: Iben Maria Zeuthen. Idé, tilrettelæggelse og redaktør: Mikkel Clausen. Klip og mix: Jacob Heldt. (Sendt første gang 16. september 2020).

I dagens program handler det om, hvorvidt mundbind egentlig kan give problemer, forældres velmenende fejl, belejligt tyveri, brugsanvisninger og løse forhjul. Om et øjeblik bliver mundbind obligatorisk i al kollektiv transport. Flere steder i verden spreder der sig en vis skepsis over for mundbind, og vi efterlyser derfor en dansker, der nægter at bruge mundbind. Christoffer ringer ind, og han kommer FANDEME ikke til at bruge det pis. Vi vil også gerne tale med nogen, der rent faktisk har fået et reelt problem ud af at have noget op foran munden. Helle ringer ind og fortæller om et problem på plejehjem, som vi aldrig selv havde tænkt på. Thomas har også været i mundbindsproblemer, som ramte ham hårdt på et tysk værtshus. Jacob fortsætter med at fortælle dramatiske historier fra græske mytologi. I dag er det myten om Ikaros, der kommer under kærlig behandling, og vi efterlyser andre, der også har modtaget en kæmpe bjørnetjeneste fra deres forældre. Michael har engang fået slået nyren løs af sin mors velmenende råd. Vi trækker en seddel og efterlyser folk, der var virkelig glade for at blive bestjålet. Alexander fik stjålet sin Moncler-jakke til 8000 kroner på skiferien, og heldigvis tjekkede forsikringspengene hurtigt og belejligt ind. Nyhedsbingo sender os i dag jagt efter folk, der har misforstået en brugsanvisning. Stig har en utrolig historie om en svensk misforståelse og en direktør, og Christoffer fik ikke nærlæst bagsiden af en hårfarve. Vi runder af med "Det Værste Jeg Kan Forestille Mig", som i dag skal handle om at tabe forhjulet, mens man kører. Det har Tobias prøvet på sin BMX, og det endte faktisk ok. Værter: Andreas Kousholt og Jacob Weil.

På sin venstre skulder havde Carstens stedsøn, Raph tatoveret en Ikaros-vinge, inspireret af den græske myte om drengen Ikaros, der flyver for tæt på solen, brænder vingerne, falder ned og dør. Spørgsmålet er om menneskeheden også er fløjet for tæt på, eller om vi stadig kan nå at lime vingerne fast. Tilrettelæggelse og indtaling: Iben Maria Zeuthen. Idé, tilrettelæggelse og redaktør: Mikkel Clausen. Klip og mix: Jacob Heldt. (Sendt første gang 16. september 2020).

Sagen des klassischen Altertums geschrieben von Gustav Schwaab "Vom Lesen zum Hören" Podcast ist ein Vorlesepodcast von Ron Härtl. In dem Podcast werden überwiegend Schriftstücke aus dem Projekt Gutenberg vorgelesen. Vorschläge, Anmerkungen können gerne als Kommentar oder via E-Mail an VLZHPodcast@gmail.com gesendet werden. Der Podcast wird produziert von Ron Härtl Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International Lizenz. Links: Wiki: Minotauros Wiki: Europa (Tochter des Agenor)) Wiki: Ikarus Wiki: Ikaria wiki: Leonardo da Vinci Wiki: Gebrüder Montgolfier Wiki: Otto Lilienthal Wiki: Gustav Weißkopf Wiki: Gebrüder Wright Annette Kuhn: Warum sitzt Europa auf dem Stier? Matriarchale Grundlagen von Europa Artikel: Der erste Motorflug der GeschichtWiki: Minotauros Wiki: Europa (Tochter des Agenor)) Wiki: Ikarus Wiki: Ikaria wiki: Leonardo da Vinci Wiki: Gebrüder Montgolfier Wiki: Otto Lilienthal Wiki: Gustav Weißkopf Wiki: Gebrüder Wright Annette Kuhn: Warum sitzt Europa auf dem Stier? Matriarchale Grundlagen von Europa Artikel: Der erste Motorflug der Geschicht Hörempfehlung: Troja Alert Podcast Werbung Bitte nutzen Sie für die Suche im Internet Ecosia, die grüne Suchmaschine, auch im Google Playstore zu finden. Ecosia ist nicht nur CO2-neutral, sonder ist sogar CO2-negativ (weitere Informationen finden Sie hier)

Dr. Mitul Gandhi, a medical oncologist specializing in hematologic malignancies at Virginia Cancer Specialists, which is part of the US Oncology Network, highlights key abstracts from the #ASCO20 Virtual Scientific Program that aim to improve outcomes for patients with multiple myeloma. Transcript ASCO Daily News: Welcome to the ASCO Daily News Podcast. I'm Geraldine Carroll, a reporter for the ASCO Daily News. I'm delighted to welcome Dr. Mitul Gandhi, a medical oncologist with Virginia Cancer Specialists, which is part of the US Oncology Network. Dr. Gandhi's clinical and research focus is in malignant hematology.   Today he will highlight key abstracts featured at the ASCO20 Virtual Scientific Program and discuss the potential of new agents and treatment approaches to improve outcomes for patients with multiple myeloma. Dr. Gandhi reports no financial conflicts of interest relating to the issues discussed in this podcast. Full disclosure is relating to all daily news podcasts can be found on our episode pages.   Dr. Gandhi, welcome to the ASCO Daily News Podcast.   Dr. Mitul Gandhi: Thank you for having me. I really appreciate the opportunity to review the abstracts from this year's meeting.   ASCO Daily News: Can you tell us about the abstracts that will likely support new standards of care?   Dr. Mitul Gandhi: So within the world of multiple myeloma, there were several exciting studies that were conducted with investigational agents that are new, and then repurposing existing agents in different lines of therapy. When reviewing this, while it may not change how we practice tomorrow, it certainly informs what may be in the very near future.   I think a representative abstract is 8500, presented by Dr. Richardson and his colleagues, and involved a novel compound CC-92480 in relapsed refractory myeloma. And this is an interesting compound, which is a Cereblon ligase modulator and a next iteration of agent based on the Revlimid and, rather, lenalidomide and pomalidomide mechanism acting on Cereblon and degrading Ikaros and Aiolos.   And this was a phase I study with a phase II expansion based on the maximally tolerated dose. And what they found were that this agent studied in heavily pretreated myeloma patients, all refractory lenalidomide, pomalidomide in the majority refractory to anti-CD38 antibodies. This drug was still able to achieve a response across several dosing cohorts.   They had a complex study design involving twice daily along with once daily dosing, and a 1.0 milligram-per-day dose was identified as a MTD. And at that dose, they found 48% of patients achieved a response, with correlative studies demonstrating degradation in Ikaros and Aiolos consistent with the mechanism of action.    And so what it tells us is that this mechanism still remains a potent avenue for exploitation in spite of progression on first- and second-rate generation compounds like lenalidomide and pomalidomide. So this informs possible changes in the future, where we would continue to use a compound like CC-92480 in spite of progression on the existing agents.   And we can see itself working in earlier lines of study and complexing with other compounds to the increased response rate. So this is something that we think will be relevant in the future if not relevant tomorrow in terms of standard of care.   ASCO Daily News: There have been substantial improvements in survival for patients with multiple myeloma in recent years, thanks to the introduction and widespread use of multiple novel agents and regimens. Are there new treatment approaches or agents in development that people should be aware of?   Dr. Mitul Gandhi: Absolutely. I think this can be viewed in a few ways. As all the listeners are well aware of and have experience with, the monoclonal antibodies on top of the existing backbone of treatment that has led to significant improvement and outcomes with relapsed refractory patients, both with daratumumab and elotuzumab.   Daratumumab, of course, being in an anti-CD38 antibody and elotuzumab targeting SLAMF7. There are next-generation antibodies on the anti-CD38 backbone, such as isatuximab. And that was studied in abstract 8508 in high-risk multiple myeloma by Dr. Weisel and colleagues from Germany.   So this particular study kind of captures what the goal is, which are moving these monoclonal antibodies higher up in the lines of therapy. So this particular trial looked at higher risk multiple myeloma, defined by chromosomal aberrations, such as deletion 17p, translocation (4;14) or (14;16), or excess copies of 1q21.   These patients received isatuximab on top of the KRd backbone, with an option for pursuing stem cell transplantation. There were 50 patients in the initially presented data -- 46 in the transplant eligible; 4 in the transplant ineligible. And one of the striking things that was identified was a 46% complete response rate in a otherwise high-risk cohort.   So this is emblematic of what the field is moving towards, which is incorporating these novel antibodies on top of an established backbone and seeing better response rate that were initially met. And as an increasing amount of data identifies achieving lower and lower myeloma burden and hopefully MRD negativity, minimal residual disease negativity, earlier on, pretending long-term, better outcomes, incorporation of these novel antibodies is one - exciting, and two - it will hopefully help inform the next generation of therapy.   Notably, these results are still preliminary phase II studies. And longer term follow up will be needed to identify if they are better than the existing outcome. Another study in that same vein is abstract 8507, presented by Dr. Zafar and his colleagues from SWOG, incorporating elotuzumab with the RVd backbone for, again, newly diagnosed, high-risk multiple myeloma.   They define high risk in a similar vein as a German group with translocation (14;16), (14;20), 17 p or gain of 1q21. And they took 103 patients, randomized them to RVd or RVd plus elotuzumab. They found at 53 months median follow up, a relative similarity in the progression-free survival. 31 months for RVd and 34 months for elo RVd with a P value of 0.449.   And there was no overall survival observed, albeit that truncated follow up. Notably, there were higher rates of response with the incorporation of elotuzumab. And so what this study validated is it's certainly using the proteasome inhibitor backbone. But maybe switching the antibody to increase response rates has, at least at this first analysis, there was no improvement in PFS.   Nonetheless, I think it's an important study, as the goal seems to be incorporating novel compounds on top of an existing backbone to improve depth of response. So these are two representative abstracts, which shows where the field is moving. And the patients that are relapsed and refractory, a slew of other studies targeting anti-BCMA are particularly exciting and relevant.   The DREAMM-6 study, abstract 8502, presented by Dr. Nooka,  used belantamab, which is an antibody drug conjugate targeting the BCMA B-cell maturation antigen conjugated to a cytotoxic payload. And in heavily pre-treated penta-refractory patients, they achieved an impressive response rate, with a clinical benefit rate of almost 80%, which is exciting, as these are patients with limited treatment options.   This is a novel mechanism of action with evidence of excellent responses, many that seem to be durable. It did have a unique toxicity profile, which is increasingly being recognized with cutaneous toxicity. So incorporation of opthalmology and identification of mitigation strategies are going to be important as more familiarity is gained.   But there are a number of further studies that are being pursued with belantamab. In context of this, there were three cellular therapy protocols also presented -- abstract 8503 by Dr. Munshi and colleagues, and abstract 8504 by Dr. Mailankody and colleagues, and abstract 8505 by Dr. Berdeja and colleagues. All three were abstracts around cellular therapy using a CAR T construct targeting BCMA with three different compounds.   And all three looked at similar patient populations with heavily pretreated patients. Abstract 8503 by Dr. Munshi looked at 140 patients penta-refractory and triple-class refractory that were treated with this compound in escalating doses. They found at the highest dose cohort at 450 times 10 to the 6 cells, an overall response rate of almost 82%, many of them durable with durability at median of 11 months.   This was associated with cytokine release storm along with some neurotoxicity, both at night, rather, at 96% and 20%, respectively-- but well managed. Similar findings were found on the other cellular products. Orvacabtagene presented by Dr. Mailankody on abstract 8504 and a Juno product in abstract 8505 by Dr. Berdeja. There was evidence of cytokine release and neurotoxicity in both. But again, with significant response rates in heavily treated patients, many of them durable. So altogether, it shows that an  extension beyond what we discussed initially, where there is next generation of compounds on existing mechanism of actions, these series of abstracts are looking at incorporation of monoclonal antibodies, improving on outcomes in first-line therapy, along with targeting BCMA through either an antibody drug conjugate or through cellular therapy, eliciting responses in very heavily pre-treated patients. Many of them are durable. But with a unique set of toxicities ranging from cutaneous to cytokine release storm.   ASCO Daily News: Dr. Gandhi, are there any other clinical trials that really stood out for you this year?   Dr. Mitul Gandhi: So a few other abstracts I think that are worth noting, with respect to the clinical trials question, I think with the data that's been presented in the abstracts we've talked about, they inform the next generation of studies as we build upon the outcomes that were presented for more mature data, longer term data, and novel combinations.   A few other studies that I think were informative -- abstract 8509, presented by Dr. Kumar and colleagues, involving venetoclax plus bortezomib and dexamethasone in relapsed refractory myeloma. This was interesting because we know that venetoclax seems to have preferential sensitivity and rearranged (11;14) patients for BCL-2 high.   And what the study found in a randomized fashion of 291 patients-- 194 to the venetoclax arm and 97 of the placebo-- in the patients that had a rearranged (11;14) translocation were felt to have BCL-2 high, median duration of PFS was not reached compared to 9.9 months in the placebo arm.   So this is an impressive targeted therapy in a subset of patients. It seems to enjoy very long-term responses in spite of being heavily pretreated with venetoclax, which is a drug that's increasingly gaining experience across a wide swath of hematologic malignancies. And so it speaks to the heterogeneity of this disease and perhaps targeting on a more genomically stratified approach with these targeted compounds.   There are a few other studies I think might be relevant for practical matters on a day-to-day basis in the clinic. One of them was 8518, presented by Dr. Ailawadhi and colleagues, regarding the use of RVd in newly diagnosed myeloma with renal impairment. As we know, many of our patients can present with myeloma-associated kidney dysfunction, whether through light-chain deposition disease or a cast nephropathy with high light-chain levels.   And there sometimes is a bit of a trepidation in administering Revlimid in this setting out of concern for toxicity in the setting of depressed GFR. They performed a retrospective analysis and found that even in patients with baseline depressed GFR ranging from less than 30 or between 30 and 60, the incorporation of lenalidomide helped achieve almost equivalent outcomes in patients compared to patients who had a preserved GFR greater than 60.   So in their transplant-ineligible patients, for example, they found a median PFS of 36 months compared to 30 months in people with and without creatinine clearance less than 60. In their transplant-eligible patients, interestingly, they found a PFS of 48 months versus 43 months in the same cohort. So this speaks to the ability to safely administer this drug in achieving nearly equivalent outcomes compared to the people who have baseline intact kidney function.   So with appropriate monitoring, modification of dosing, and attention to myelosuppression, it seems as though we should be using lenalidomide-based induction therapy, which we would otherwise would if the patient's GFR was preserved and still able to achieve long-term durable responses.   A couple of other smaller studies that I think are worth mentioning include abstract 8515, presented by Dr. Cornell and colleagues, regarding bortezomib induction in light-chain amyloidosis prior to autologous stem cell transplant. There has been some question regarding what the best induction strategy is in patients who presented with light-chain amyloid.   And so this was a retrospective analysis of the CIBMTR database. We're looking at patients who had received a bortezomib-based induction versus no induction prior to proceeding with a stem cell transplant using high-dose melphalan. And it was fairly clear in their followup that a bortezomib-based induction was associated with decreased risk of relapse within two years -- 13% in the bortezomib arm versus 22% in the patients that presented directly to transplant -- and translated into overall longer PFS as well.   So this validates the use of bortezomib in patients prior to stem cell transplantation in a niche population with amyloid. Similarly, abstract 8516, presented by Dr. Zhang and colleagues, questioned whether the incorporation of an alkyqlating agent on top of this proteasome inhibitor backbone would help in these patients with light-chain amyloid.   There has been an increased use of cyclophosphamide, bortezomib, dexamethasone induction based on smaller phase II studies. So this group looked at retrospectively a bortezomib plus an alkylating backbone versus one with bortezomib alone. And found that the overall hematologic response rate was fairly similar -- 73% in the patients that received bortezomib plus an alkylator versus 85% that did not, which was not statistically significant.   So it seems as though while there is a temptation to use the alkylator, it may not be necessary. And bortezomib alone may be sufficient. But of course, it would be on a case-by-case basis. But it adds to the body of literature regarding how to treat these patients with amyloid. So I thought those were helpful analyses in a smaller population but which may be relevant tomorrow in clinic.   ASCO Daily News: Well, thank you, Dr. Gandhi, for sharing your valuable insights on these promising developments in this field.   Dr. Mitul Gandhi: Thank you for the opportunity. I appreciate it.   ASCO Daily News: And thank you to our listeners for joining us today. If you're enjoying the content on the podcast, please take a moment to rate and review us on Apple Podcast.   Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

I denne episode har jeg besøg af Thor Wowk Larsen. Thor arbejder til dagligt som konsulent i CMS Denmark. Her hjælper Thor fitnesscentre, crossfit-boxe, PT-studios og trænere med at optimere deres produkt og forretning.Thors vej ind i træningsverdenen kom via. en interesse for crossfit, som senere ledte ham over i vægtløftning.Thor er i dag også Eurosports go-to-guy, når de skal have fat i en kommentator til OL, VM og EM i vægtløftning.Vi fik os en snak om Thors vej ind i træningsverdenen, vægtløftning, doping samt Covid19 og dens påvirkning på fitness-Danmark.Det var en super god snak.God fornøjelse

Managing contracts can be a massive time suck but also an often under-utilised way of mining for gold when it comes to discovering savings opportunities. In this podcast, I speak to Daniel Barnes of Ikaros Consultancy. Daniel is a law graduate and also recently launched his own podcast, World of Procurement. We talk about how the human touch, combined with automation of repetitive tasks, is the best solution when considering how to best manage your supplier contracts. Contract Management – Daniel Barnes from Ikaros Consultancy 2:42 Daniel explains how he landed into the contract management space in the procurement world. 6:30 How Daniel took his experience working on government defence contracts and was able to take these key learnings into the private sector and civilian industries. 7:38 Are there significant differences in approach when considering smaller businesses versus larger corporates? 9:45 How the technology and resources could be different depending on the size of the business and the amount of contracts processed in any given organisation. 11:28 I ask Daniel whether it's better to approach contract management by size of spend basis first and foremost, or by category. The answer he gave was not what I was expecting. 13:20 A funny story of the building with no windows which nonetheless had £100k of invoices for replacement of windows. 16:00 We talk technology, and the advantages and limitations of using tech to be able to make contract management easier. 20:52 Why a digital contract management solution will only work if your organisation is ready to embrace it and your existing systems and processes can support it. 22:40 How to build a business case for a contract management solution. Is it primarily cost avoidance? And if so, how to convince a CFO to part with their budget to implement a solution to successfully manage it? 25:52 Does operational and tactical procurement have a future? Daniel has some pretty strong views on how these roles will likely be eliminated over the coming years. How to connect with Daniel: https://www.linkedin.com/in/danielbarnesgsd/ (Daniel's LinkedIn profile) https://ikaros.uk.com (Ikaros Consultancy website) How to connect with James: https://jamesmeadsconsulting.com/ (James Meads Consulting website) https://linkedin.com/in/james-meads/ (James' LinkedIn profile) https://bookme.name/jamesmeads/lite/initial-consultation (Book a Call with James) https://linkedin.com/showcase/procuretechpodcast (Follow The Procuretech Podcast on LinkedIn)

Fotballen starter opp snart og vi snakker med Sjanten fra Ikaros om tribuneliv, hvordan fotballkamper uten tilskuere kommer til å bli og litt om turene vi kommer til å gå glipp av. Og hva sier du egentlig til sjefen når bussen har knela midt på fjellet og du ikke kommer på jobb mandag?

I got your DMs. I saw your comments. You want to know which Costa Rican Ayahuasca retreats are most worth your time and money. I had way too many messages to respond to each of you with a thorough enough explanation, so I decided to create this detailed analysis of Rythmia and Soltara, offering a side-by-side comparison of my experiences. But let me just get this out of the way first: there is no clear winner here. This is like vanilla vs chocolate, lemons vs limes — they’re just different flavors! The major defining difference is that Rythmia is a resort and Soltara is a retreat center, and I’ll get into how that translates into your experience in the episode. My honest advice would be to flip a coin, then go to both of them if you can! And if you have no idea what I’m talking about, go back and check out the two episodes I released about Soltara on Tuesday and the two episodes I released about Rythmia back in April 2019: Episode 202: Welcome To The Jungle: My Ayahuasca Journey At Rythmia Part One Episode 203: Welcome To The Jungle: My Ayahuasca Journey At Rythmia Part Two Episode 262: Jungle Journeys: My Ayahuasca Awakening At Soltara (Part One) Episode 263: Jungle Journeys: My Ayahuasca Awakening At Soltara (Part Two)   10:15 — Let’s start with the cost: This is based on staying there for 7 nights Rythmia: $3,500 - $5,700 Soltara: $1,750 - $3,750   11:05 — Location, Property, & Travel: The Liberia airport for Rythmia is more chill, closer to the center. It’s about a three-hour shuttle from the airport to Rythmia, so you can fly in the same day and go straight to Rythmia, whereas you need to stay in San Jose when you land and then travel to Soltara the following day. San Jose is a much more hectic city, with a long journey from city to Soltara, including a ferry ride. But that may be a plus if you want to see more of Costa Rica! I rented a car at Soltara, which was great. Soltara is only two hours from Santa Teresa, an amazing surf town. I would rent a car if I went to Rythmia again, to allow for travel. Rythmia allows you to leave the property during your stay, but Soltara does not. Soltara is a much more remote location, so nowhere to go anyway. Soltara right on the beach, with walking access to two beaches. Rythmia is a 10-minute drive to two larger beaches, more space to walk, swim. You can listen to the waves during the ceremony at Soltara. Most epic sunrises ever at Soltara. Steep hill to rooms at Soltara, which is hard to climb on medicine Beautiful grounds with a swimming pool. Soltara does not allow pool use after the ceremony, but Rythmia does. Both spots have super clean, air-conditioned rooms. Soltara rooms are newer and slightly more modern. Both spots have shared room options that are cheaper than solo rooms. Soltara is a smaller more intimate property with fewer buildings, whereas Rythmia is more of a tropical resort vibe with bungalow-style housing, a full medical clinic, a hot tub, a cool plunge (wish it was cold), and a great non-toxic steam room Both places have a gym. The Soltara gym is more modern, with CrossFit, functional movement tools, and free weights. The Rythmia gym is more like a hotel gym with machines. I also had a hard time using the Rythmia gym due to fake news CNN blasting on not one but three TVs in front of the treadmills. Another nice feature at Rythmia is the availability of bodywork and colonic treatments, available for an additional fee. All in all, both properties are beautiful and allow for plenty of space to spend time alone to reflect and relax. I have to say the maloca, which is a gigantic dome structure used at Soltara, added a lot to the experience for me. It’s a magical building and it is just spectacular to experience during ayahuasca. The soundscape of the surrounding wildlife, and even dogs and farm animals, was epic. That said, the ceremony room at Rythmia is also beautiful, just a bit more of a traditional building. One nice touch at Rythmia was the availability of a golf cart ride back to your room if you were unable to walk. I think I had one such night. Another plus at Rythmia was the giant fire pit that was lit each night during the ceremony. When I needed to shift my energy, I would walk outside and sit by the fire and pray. I liked being able to leave the ceremony room to go outside and regroup at Rythmia, while it is required that you stay in the maloca for the entire ceremony at Soltara. But I totally understand, since the property at Soltara sits atop huge ravine, whereas Rythmia is flat, making it harder to screw up. At Soltara, once the official ceremony is over, however, you are free to roam about the main areas of the property, including the insanely beautify sky deck with overlooks the sea and those gorgeous sunrises.   26:40 — Food & Drink: Due to the fact that Soltara follows the Shipibo diet tradition very closely, the food followed those guidelines and, as a result, the food is purposefully bland, without salt, fats or sugar. While the food at mealtimes was very healthy, organic, fresh, and abundant, it was hard to feel ‘full.’ But that's what the diet is all about.  While both Rythmia and Soltara recommend a similar diet for some time before arriving for ceremony and during (no coffee, no sex, no drugs, no red meat, no pork, etc), I was relieved that Rythmia was much looser on the food restrictions once I arrived. They even had coffee available, although I used it very sparingly.  It’s worth noting that there seemed to be a lot more purging going on at Rythmia, which might have something to do with the more lax food rules. There were also more hearty snacks available at Rythmia, which I enjoyed. I personally preferred the looser approach to food at Rythmia. I also very much respect that Soltara follows ancient traditions closely. I also learned my lesson RE: eating food AFTER ceremony at both places, as I did get strong flashbacks when I ignored that advice.   29:10 — Itinerary & Activities: Rythmia offers a very full agenda of activities, talks, and a robust educational curriculum that was spot on in its approach to integrating a new mindset and metaphysical approach via Michael Beckwith’s companion teachings, etc. Some of the talks were mandatory, while others were not. Despite the fact that all of the speakers and activities at Rythmia were top-notch, I did feel I was always on the go, having to be somewhere (keep in mind I was also recording a lot of interviews and such while I was there too). Between the voluntary colonics, spa treatments, and classes, I longed for more time to just chill out and rest at Rythmia. Alternatively, Soltara allows you a grip of free time every day to nap, go to the beach, read, journal, whatever. There were only a couple of mandatory talks, which were very helpful and supportive, as well as offering a way to get to know your fellow ceremony friends. All in all, the general flow is way more laid back and mellow at Soltara, both in ceremony and out. I think the classes and other supportive offerings at each place would be very useful to people, depending on how much personal growth work they had done prior. Rythmia offers such a fully immersive learning experience, and it would be great for someone who’s just getting into spirituality and personal development work.  Soltara gives you a lot of space to do your own work in your own time, which might better support someone who’s had more experience with plant medicine and meditation beforehand. In terms of my fellow attendees’ prior experience with ayahuasca, the majority of people at Soltara were doing it for the first time, with only a couple of us having done it before, while many more people seemed to have had prior experience at Rythmia. That might have been due to the fact that my Rythmia group was 40 people, vs 20 at Soltara. The smaller group at Soltara would be much easier for some people to manage, but I didn’t really have a preference in terms of numbers. Once I'm in a ceremony on the medicine, I couldn’t care less if there were 10 people in the room or 100. I'm doing my own thing.    36:10 — Ceremony & Traditions Each place has a very different approach to ceremony, although they both typically offer four ceremonies in the seven-day packages Soltara follows the Peruvian Shipibo tradition to a T, even down to the two maestros (or healers) that lead the ceremonies. All four nights at Soltara are exactly the same, with the same shaman leading, drinking the same exact batch of medicine brewed by Shipibo people in Peru that was shipped up to the center.  At Soltara, there are two healers supported by the same two facilitators each night. At Rythmia, there are a number of different shamans serving the medicine and facilitating the ceremony each night. There might be 4-6 main healers, with up to a dozen support staff on hand to tend to you.  At both places, I was made to feel completely safe and watched over by the staff, but there were just more of them at Rythmia, likely due to the fact that there was double the number of attendees. One thing I really liked at Soltara was that we had a really nice yin yoga session in the maloca each night leading into the ceremony. This was a great way to slow down and become very present in my body, and become completely relaxed with slow breathing and light stretching. At Rythmia, each night provides a completely different and novel experience.  The brew at Rythmia is from a different country each night, and one night the medicine had been cooked on site. At Soltara, the soundscape is VERY different. The only sound is the sweet Ikaros being sung by our Shapiro healers. There are no instruments played, no pre-recorded music, nothing. This provided its own powerful experience, but generally was MUCH more chill than Rythmia, and the whole scene is more introspective. Stillness pervades the maloca. It is also pitch black with ZERO light at Soltara throughout the entire ceremony. In contrast, on any given moment at Rythmia, someone could be up front dancing or performing songs together. At Rythmia, the music is always changing and goes all night. Countless people perform all varieties of live, traditional music, as well as the presence of almost non-stop recorded music during other times. There are moments of stillness and quiet, but overall there is a very beautiful circus of sounds present from the moment the ceremony begins until the early AM when people tend to wander back to their rooms. I loved the stillness and silence at Soltara, but it could be unnerving to someone who has not spent a lot of time with themselves, so to speak. But the near-constant motion and bells and whistles of the Rythmia experience could also be a bit overstimulating to someone not used to such a multi-sensory experience. I personally liked both styles of ceremony for different reasons. The moments at Soltara when the healers come sit directly in front of you and sing their Ikaro to you is something I will cherish forever, as it is just one of the holiest things you could ever hope to experience. Once the Soltara ceremony officially ends and the healers exit the maloca, there are no more sounds or sights to be had. You are on your own to sit and pray with the medicine. At times, I found this rather alarming, as it’s common for the medicine to hit me during or even after the official ceremony has ended. During the ceremony at Rythmia, it pretty much goes on all night until everyone is done. There is never a dull moment in the Rythmia ceremony. That, of course, depends on who is leading at Rythmia, and what tradition they are following that particular night. Each night is VERY different, whereas at Soltara is always the same.  The sameness at Soltara has its own sweetness, as each progressive night you sort of sink into the ceremony with increasing comfort and familiarity. Another aspect worth noting is the smells! At Soltara, all you smell is the very pleasant odor of mapacho, the sacred tobacco smoked throughout by both the healers and participants alike, along with the faint smell of the Shipibo perfume made of a traditional brew of certain plants, flowers, and essential oils. At Rythmia on the other hand, each night you are overwhelmed with every sacred ceremonial smell imaginable — paulo santo, mapacho, copious amounts of copal incense, and a number of different brews of the perfume mixture. For some reason, I found the perfume smell at Rythmia nauseating, and each night I would pray they didn’t spray it near me. It reminds me of cheap, toxic perfume, like one you might buy at a dollar store. I was assured that it was non-toxic, but whatever it was, I disliked it to the point that I promised myself I would bring a dust mask next time I attended to block the smell from invading my nostrils. Other than that perfume, I loved the variety of smells at Rythmia, as powerful as they were at times. Another minor difference was the abundant use of Rapé or “hape” at Rythmia. it's a mixture of special tobacco and herbs, ground into a fine powder and administered as snuff by a shaman blowing it in your nose. It’s quite jarring to me personally, as I've never been one to snort tobacco. While I see its value and place in ceremony, I personally prefer taking in my tobacco via smoking mapacho at Soltara.   47:38 — Integration While both places offered a lot of advice on how to integrate the experience afterward, Soltara placed a bit more focus on this element by holding talks about it and providing a useful workbook to help you document and integrate the experience both before and after your time there. I think different people will find various ways to integrate based on their lifestyle and support system back home.  If someone has experience with plant medicines and has people in their lives back home who have shared similar experiences, integration could be a bit smoother than for someone new to all of this, with less support back home. This is why I elected to take some time to myself in Santa Teresa after my Soltara visit. I can't imagine getting on an airplane the day after a retreat ended at this point. Taking time in nature to reflect on the experience was critical for me.  That said, most people do in fact hop on a plane and head right home after both places so I'm sure it's quite possible to achieve successful integration that way as well. That's what I did after Rythmia earlier this year, and I lived to tell the tale.   49:50 — Summary In the end, I think each person has to follow their own heart when choosing a center, and between these two you are in such good hands either way.  I would not personally recommend just randomly doing plant medicines with people you don't know in a random ‘hope it all works out’ sort of way. These medicines are incredibly powerful and require the utmost respect from both the practitioners and the participants. Whether you choose either one of these centers, a different one, or something closer to home, please do yourself a favor and do your research to make sure that you’re in good hands and that you are able to feel safe and well looked after, especially if you are new to the world of plant medicines.   More about this episode. Watch it on YouTube.   Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // https://www.instagram.com/lukestorey/ FACEBOOK - https://www.facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // https://twitter.com/MRLUKESTOREY YOUTUBE - https://www.youtube.com/c/LukeStorey HELP SUPPORT THIS SHOW! Love the Show? You’ll really love Luke’s Master Market Online Store!  It’s a win/win! Get direct links to all of Luke’s hand-picked biohacking and health products all in one place, get exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW.   Other ways to support:  SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals   Resources Soltara.co Instagram: instagram.com/soltarahealingcenter Facebook: facebook.com/soltarahealingcenter www.rythmia.com Instagram: www.instagram.com/rythmia_ Facebook: www.facebook.com/rythmia Biohack My Travel online class waitlist: www.lukestorey.com/travel or text BIOHACKMYTRAVEL to 44222 on any US phone   Related Shows Episode 202: Welcome To The Jungle: My Ayahuasca Journey At Rythmia Part One Episode 203: Welcome To The Jungle: My Ayahuasca Journey At Rythmia Part Two Episode 231: The Mexico Show: Farm To Table, Wildlife Preserve Eco-resort W/ Alix Goldsmith Marcaccini Episode 262: Jungle Journeys: My Ayahuasca Awakening At Soltara (Part One) Episode 263: Jungle Journeys: My Ayahuasca Awakening At Soltara (Part Two)

Today’s two-part episode was recorded in the mountainous tropical forest of Costa Rica’s Nicoya Peninsula, featuring a play-by-play account of my eight-day experience at Soltara Healing Center.  These are my raw, intimate, and uncut thoughts after traveling to Costa Rica, dealing with an EMF nightmare of a hotel room, and embarking on four ayahuasca ceremonies, this time in the Peruvian Shipibo tradition — and, to be honest, I had second thoughts about putting these episodes out.  I’m pretty much an open book on this show, don’t get me wrong, but it’s hard to be more vulnerable than the morning after an ayahuasca ceremony. In addition to recounting the first six days of my time in Costa Rica, this episode also features an interview with Melissa Stangl, a Founding Partner and the Chief Operating Officer of Soltara Healing Center. Melissa left Corporate America back in 2015 and has since used her background in engineering, science, and management to help advance the plant medicine and psychedelic movements. She’s helping to bridge the gap between the Western world and the incredible healing potential of plant medicines and holistic health, and the way she combines compassion and science definitely helps you feel safe before embarking on this profound inner journey. In part two of my Jungle Journey, which also releases today, I’ll share what happened on my last two days in Costa Rica, plus an interview with Todd Michael Roberts, the lead facilitator at Soltara, and Daniel Cleland, the co-founder of Soltara. But that’s not all!  As many of you know, this isn’t my first plant medicine retreat in Costa Rica. And when I came back from Soltara, there’s one question I got more than any other: which is better, Soltara or Rythmia? I can tell you now that neither is better or worse than the other, they’re very different experiences, but this Friday I’ll be releasing a detailed side-by-side comparison of the two Costa Rican retreats to help answer any questions you might have.   07:45 — Field Report #1: Hacks for a long flight + EMF-ridden hotel room I was able to meditate for nearly three hours of my flight with help from the NuCalm Plus a one-hour Joe Dispenza meditation to put myself in a great emotional state before arriving I wore earplugs from the moment I got out of my car at LAX to the moment I left the airport in Costa Rica Clear and TSA Precheck will help you get past a lot of the stress and chaos of the airport To deal with the crazy energetics of the plane, I always bring two devices: the Blushield cube and the Somavedic travel unit. Samina pillow for comfort Comrad compression socks Get Lambs EMF-proof beanie and underwear My secret weapon is my KTC Lab EMF sleeping bag (which isn’t commercially available yet, but I’ll let you all know as soon as it is) Vital Reaction hydrogen tabs (four every 90 minutes while flying) Three Quicksilver Scientific supplements: The ONE Mitochondrial Optimizer, Liposomal Glutathione, and Keto Sleep Protocol Magtech Magnesium Complex Quinton Purified Seawater Solution Kratom for back pain Therasage Heating Pad - also for back pain Realizing I’m sleeping immediately under a cell tower and surrendering to it Sometimes surrendering to the moment will yield a sauna Biohack My Travel online class waitlist: www.lukestorey.com/travel or text BIOHACKMYTRAVEL to 44222 on any US phone   24:15 — Field Report #2: Arriving at Soltara Driving up the coast in my janky rental car Taking a ferry over to the Nicoya Peninsula I found some amber incandescent bulbs at a local hardware store Chilling in the maloca, an indigenous Amazonian structure Anticipating tomorrow’s purging ceremony, a part of the Peruvian Shipibo tradition   29:20 — Field Report #3: Before my first ceremony Recorded two hours before my first ceremony Why I ended up appreciating the vomitivo purging ceremony Our 90-minute orientation The crazy equatorial sun Cleansing in a flower bath Meeting our healing guides   34:15 — An interview with Melissa Stangl  Working through shoulder pain during the ceremony It’s so easy to not listen to your body, but it pays to do the work of being grateful for the wisdom of your body The nature of realization on ayahuasca Working to live Vs. living to work Melissa’s first introduction to psychedelics Meeting Daniel Cleland through Reddit Choosing to follow your intuition instead of doing what you feel like you’re supposed to do Letting go of the fear of how you will be perceived Opening up to the possibility that there’s a lot more that we don’t know about life and the nature of existence Why Soltara practices the Peruvian Shipibo tradition Ikaros healing songs As plant medicines grow in popularity around the world, Soltara is trying to preserve a connection to the indigenous tradition The ultimate way to get the most out of your healing is to feel safe first The role of tobacco in ayahuasca ceremonies + the nootropic effect of nicotine The oldest & youngest people that Melissa has seen take the medicine My visual, physical, and emotional experience during our first plant medicine ceremony Nothing is more powerfully personal than what Mother Ayahuasca shows you Drugs Vs. Medicine Ayahuasca and addiction The founder of the 12-Step Program’s history with psychedelic experiences Working with other plant medicines   01:54:30 — Field Report #4: Reflecting on my first ceremony + preparing for my second My first ceremony was more mellow than I expected, counter to my expectations of a very intense experience… and it was kinda my fault But I’m not making the same mistake on my second tonight! My secret stash of cashews The transformative experience of listening to Joe Dispenza after the ceremony   02:01:20 — Field Report #5: Day five, after my second ayahuasca ceremony Consulting with our two maestros, a wonderful couple who has been carrying on the Shipibo tradition An hour of yin yoga, a very gentle yoga practice that was great preparation for the ceremony The use of tobacco in the ceremony The angelic voices of our guides singing the Ikaros My process of psychedelic, introspective inquiry; talking to “them” and getting answers Exploring gratitude, humility, and inferiority Meeting an awesome listener (shout out brother!) Wild shared visions that were too powerful to be coincidences   More about this episode. Watch it on YouTube.   Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // https://www.instagram.com/lukestorey/ FACEBOOK - https://www.facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // https://twitter.com/MRLUKESTOREY YOUTUBE - https://www.youtube.com/c/LukeStorey THIS SHOW IS BROUGHT TO YOU BY: JUST THRIVE. Imagine this: a probiotic that actually does what it is supposed to do! I’ve tried so many different supplements, and when you find the right one — the one that really works — it’s like winning the lottery. So I was psyched when I tried Just Thrive Probiotic, the first and only spore-based probiotics and antioxidants. Their products have been the subject of groundbreaking clinical studies and demonstrated incomparable effects on the gut, even healing leaky gut. It’s super simple and it just works. You can use code ‘luke15’ for 15% off at www.thriveprobiotic.com/luke.   AND...   JOOVV. If you’ve been listening for a while or following Luke on social media, you’ve probably seen him raving about red light therapy, or photobiomodulation. There are over 3000 published clinical papers on light therapy – over 200 being double-blind, randomized, and placebo-controlled – making this arguably the most well-researched bio hack in Luke’s arsenal. Some of the benefits include increased skin health, better muscle recovery, better sexual performance, and reduced joint pain and inflammation. So you can see why Luke is so into it... and why all of his friends keep coming over to use his Joovv device! If you are ready to get your own Joovv device + a FREE gift, head over to Joovv.com/luke and enter the code “LUKE” at checkout.   AND…   SAKARA. The new year is a time to change your habits so that you can be your healthiest self. It can be tough to stick to a resolution, but changing your routine doesn’t have to be difficult. Sakara makes it easy to feel better, look better, and have the energy to accomplish all your goals this year. Their organic, ready-to-eat meals are made with powerful plant-based ingredients, and they are designed to boost your energy, improve your digestion, and get your skin glowing, plus daily wellness essentials like supplements and herbal teas to support your nutrition. You can get 20% off your first order using code LUKE at sakara.com/luke. HELP SUPPORT THIS SHOW! Love the Show? You’ll really love Luke’s Master Market Online Store!  It’s a win/win! Get direct links to all of Luke’s hand-picked biohacking and health products all in one place, get exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW.   Other ways to support:  SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals   Resources Soltara.co Instagram: instagram.com/soltarahealingcenter Facebook: facebook.com/soltarahealingcenter Biohack My Travel online class waitlist: www.lukestorey.com/travel or text BIOHACKMYTRAVEL to 44222 on any US phone   Related Shows: Episode 119: The Psychedelics of Sound & Breath Part One with Elian Zach Episode 120: The Psychedelics of Sound & Breath Part Two with Elian Zach Episode 202: Welcome To The Jungle: My Ayahuasca Journey At Rythmia Part One Episode 203: Welcome To The Jungle: My Ayahuasca Journey At Rythmia Part Two Episode 247: Cancer Cures, 5G EMF Update, & My Next Career Moves Episode 259: The Heart/Mind Connection & Supernatural Healing With Dr. Joe Dispenza

丽莎老师讲机器人之靠阳光航行的卫星欢迎收听丽莎老师讲机器人，想要孩子参加机器人竞赛、创意编程、创客竞赛的辅导，找丽莎老师！欢迎添加微信号：153 5359 2068，或搜索微信公众号：我最爱机器人。行星协会的实验性LightSail 2太阳帆卫星被设计用于在太阳光线下飞行。由于太阳能推动该卫星的大型反光太阳帆，该卫星已成功地绕地球运行。这标志着地球轨道上的航天器首次使用太阳帆来改变其绕行星的路径。自从6月25日SpaceX猎鹰重型火箭携带LightSail 2发射升空以来，该卫星一直处于地球上空的低轨道。该航天器成功地部署了它的“帆” - 一个薄的、方形的聚酯薄膜，大约相当于拳击台的大小。从那以后，行星协会一直在调整该航天器在轨道上的位置，以优化航天器利用来自太阳的光线的能力。到目前为止，这种轨道“舞”已经奏效了。LightSail 2已经将其部分轨道提升了大约1.7公里这种小型卫星可以单独靠光线在太空中推进。光粒子没有质量，但它们带有动量。而这种光实际上可以推动太空中的物体。通过大而薄的反射帆，航天器可以从太阳的光线中捕获足够的这种动量并改变其位置。可以驾驶宇宙飞船 - 可以在太空中获得推进力 - 在阳光下航行真的是非常浪漫的。太空中的太空“帆船”并不是新想法。2010年，一艘名为IKAROS的日本宇宙飞船在前往金星的途中使用了一艘轻帆在太空中推进。然而，行星协会想要证明同样的技术可以用于较小的卫星，特别是CubeSat卫星。对于希望使用易于构建的相对便宜的航天器从太空收集数据的公司、研究人员和更多人来说，CubeSats已经成为一个很好的工具。通过太空操纵像这样的小型卫星很困难。大多数卫星必须依靠推进器进行移动 - 微型发动机燃烧化学推进剂以推动航天器在太空中前行。这对航天器来说可能是一个昂贵的补充，这些推进器所需的推进剂增加了重量，这在从地球上发射物体时是很宝贵的。大多数时候，像CubeSat这样的小型卫星无法容纳推进器，一旦到达太空就无法操纵。这种可展开的太阳帆可以在未来添加到CubeSat中，为这些迷你探测器提供了一个选项，可以在不使用传统化学推进剂的情况下穿越太空。迷你航天器的成本为700万美元 - 大约是该组织用平均尺寸航天器完成此任务的成本的二十分之一。并分享从该任务中收到的数据，以便其他组织可能在未来使用该技术。

Den 30 augusti 2012 försvinner affärsmannen Kjell Gustafsson. Polisen står handfallen. Inte ett spår finns efter Kjell. Först två år senare får gåtan sin lösning. I en liten by i södra Sverige växer två ungdomar upp. Måns och Susanne. En gammal fejd mellan de båda ungdomarnas släkter gör att Susannes pappa Kjell inte har mycket till övers för Måns. Men Susanne trotsar Kjell och väljer att bli tillsammans med Måns. Kjell äger gårdar, skog, fastigheter och företag. När dottern som ska förvalta arvet nu väljer Måns ser Kjell sitt livsverk hotat och motarbetar förhållandet. Under sensommaren 2012 försvinner Kjell. Misstankar riktas snart mot Måns och Susanne, men polisen saknar bevis. Och mordet på Kjell är på väg att bli det perfekta brottet. Alla inblandade och flera av de vi intervjuat nämns inte vid sina riktiga namn. Vi vill varna för obehagliga inslag i dokumentären. Programmet gjordes 2015 av Sigrid Edsenius. Producent Robert Barkman. Sigrid Edsenius är reporter på P4 Kalmar, Sveriges Radio. Hon har tidigare gjort P4 dokumentärerna Mormor tyckte Hitler var tjusig, Pingstpastor Åke Green dömd till framgång och den prisbelönade Högsby ett år efter mordet (Ikaros 2006).

In questa puntata viaggiamo nello spazio sfruttando le vele solari e lo faremo in compagnia di un episodio di Star Trek DS9 in cui si naviga proprio così, sospinti dalla radiazione.

Ikaros var ifølge en græsk myte det første menneske til at flyve. Han blev eftersigende overmodig — og det kostede ham livet. Myten bruges i dag som symbol for janteloven: lad være med at tro, at du er mere end du er. Men måske er myten blevet misforstået? Måske er problemet for nutidens mennesker ikke, at vi er overmodige, men at vi er for bange for at folde os ud og gøre vores bedste? Du er velkommen til at dele dine kommentarer eller boganbefalinger med os, enten på de sociale medier, eller gennem vores hjemmesider. Danni's hjemmeside: liljekrans.com Christian's hjemmeside: christianstaal.com

Co de Kloet is dit jaar natuurlijk ook weer op InJazz te vinden. Amper bijgekomen van het festival hoor je dit weekend twee uitzendingen vol nieuwe muzikale ontdekkingen! Vanavond hoor je o.a. opnames van Jeroen van Vliet, Guy Salamon & Son Swagga en interviews met festivaldirecteur Ikaros van Duppen en kersverse Buma Boy Edgar Prijs-winnaar Jasper Blom. Playlist: Mo van der Does Quartet - August Crisis (InJazz 2019) Guy Salamon Group - Live @ InJazz 2019 Teus Nobel Liberty Group - Actual Proof Marutyri - EC Sun Odelion Orchestra - Won't Be Coming Home (InJazz 2019) Agnes Gosling 4Tet - Lilia (InJazz 2019) Jasper Blom - Homecoming Son Swagga - Dark Magic (InJazz 2019) Son Swagga - Calling All Tribes (InJazz 2019) Maite Hontele - Cuba Linda Jeroen van Vliet Moon Trio - ¾ Groove (InJazz 2019) Kijk voor meer informatie op https://www.nporadio2.nl/soulenjazz/.

Co de Kloet is dit jaar natuurlijk ook weer op InJazz te vinden. Amper bijgekomen van het festival hoor je dit weekend twee uitzendingen vol nieuwe muzikale ontdekkingen! Vanavond hoor je o.a. opnames van Jeroen van Vliet, Guy Salamon & Son Swagga en interviews met festivaldirecteur Ikaros van Duppen en kersverse Buma Boy Edgar Prijs-winnaar Jasper Blom. Playlist: Mo van der Does Quartet - August Crisis (InJazz 2019) Guy Salamon Group - Live @ InJazz 2019 Teus Nobel Liberty Group - Actual Proof Marutyri - EC Sun Odelion Orchestra - Won’t Be Coming Home (InJazz 2019) Agnes Gosling 4Tet - Lilia (InJazz 2019) Jasper Blom - Homecoming Son Swagga - Dark Magic (InJazz 2019) Son Swagga - Calling All Tribes (InJazz 2019) Maite Hontele - Cuba Linda Jeroen van Vliet Moon Trio - ¾ Groove (InJazz 2019) Kijk voor meer informatie op https://www.nporadio2.nl/soulenjazz/.

Je voortbewegen met de lichtdeeltjes van de zon die op je zeil vallen. Het klinkt op aarde absurd, maar in de (bijna lege) ruimte kan het. Je moet er wel lang voor wachten, maar in theorie kunnen de zonnezeilen snelheden van tienduizenden kilometers per seconde halen zonder te moeten steunen op een andere energiebron. Daarom worden ze momenteel gezien als de meest potentiële voertuigen om op zeer lange afstanden (inclusief een reis naar het dichts bijzijnde zonnestelsel) af te leggen. De Japanse ruimtemissie Ikaros toonde in 2011 aan dat reizen met een zonnezeil in de praktijk echt kan. Met de nieuwe missie Lightsail2 wordt er voor het eerst geprobeerd om enkel op zonne-energie een bepaald parcours om onze aarde af te leggen, met daarbij de nodige baanveranderingen en hoogteverschillen (wat nog niet eerder geprobeerd werd). Een Falcoln Heavy racket lanceert Lightsail2 morgenochtend om half 6 (samen met onder meer een speciale atoomklok voor een ander ruimteproject). We praten over de ambities en de werking van de missie met Jeanette Heiligers, astrodynamicus aan de TU Delft.

For our third interview of Anime Central 2019 we got to interview the one of our favorite Voice Actors, Brittney Karbowski! She has worked on a ton of anime including Black Star in Soul Eater, Pride in Fullmetal Alchemist Brotherhood, Ryou in Clannad, Yuri in AngelBeats, Ikaros in Heaven’s Lost Property, Nanami in Chaos Head, Eve in Needless, Yamada in B Gata H Kei: Yamada’s First Time, Chizuru in Hakuoki, Mikoto in A Certain Magical Index, Wendy In Fairytale, Rin in Little Busters,Himiko in Btooom, Manami in Cat Planet Cuties, Arisu in High School of the Dead, Cecilia in Infinite Stratos, Hitch in Attack on Titan, Sanae in Love Chunibyo and Other Delusions, Aria in Akame Ga Kill, Migi in Parasyte the Maxim, Cecil in Wizard Barristers, Vivian in Cross Ange, Cian in Project Itoh Harmony, Lute in Monster Hunter Stories:Ride On!, Ithea in World End, Karen in Gamers, Farin in The Silver Guardian, Popuko in Pop Team Epic, Pochi in Deathmarch to a Paralell World, Hisako in Food Wars, Hitoka Yachi in Haikyuu , Papika in Flip Flappers, Machi in Doreiku, Nanachi in Made in Abyss, Ravel in High School DxD,Karen in Revue Starlight, Metatron in The Seven Heavenly Virtues, Byakko in Release the Spyce, Koyomi in Bloom Into You, Nanachi in Made In Abyss, Rimuru in that Time I got Reincarnated as a Slime, and Camie in My Hero Academia! Our Links!Website: https://getjumped.blogspot.com/Instagram: https://www.instagram.com/bandsgetjumped/Twitter: https://twitter.com/BandSGetJumpedFacebook: https://www.facebook.com/BlakeandSpencerGetJumped/Support the show: https://www.patreon.com/BlakeAndSpencerGetJumpedSupport the show (https://www.patreon.com/BlakeAndSpencerGetJumped)

Uit angst overvleugeld te worden, vermoordt de vermaarde uitvinder Daedalos zijn jonge neef Perdix, die bij hem in de leer is. Veel later zal zijn eigen zoon, Ikaros, een soortgelijke dood sterven.

I detta avsnitt av Fill or Kill: Fastighetsmarknaden, Phukettrader har spaningar Svenska Spel tar bort spelreklam IMF sänker tillväxtprognos Svenska bankerna Tankar om rapportsäsongen på ingång Indextävlingen Tack till IG Markets!

This week in SF history— 24 January, 1978. Kosmos 954 decayed over russia. (wikipedia.org) — This was a Upravlyaemy Sputnik Aktivnyy (Управляемый Спутник Активный) “Controlled Active Satellite” (wikipedia.org) — Wikipedia has a great list of nuclear reactors in space, including their fates (wikipedia.org)Spaceflight news— Chang'e-4 enters Lunar night (spacenews.com) (cnn.com) — Scott Manley made a landing footage analysis video (youtube.com)Short & Sweet— Relativity Space gets a launch pad. (spaceflightnow.com)— Stratolaunch scraps its launch vehicle program. (spacenews.com)— ISRO aims to test reusable rocket technology this summer. (indiatimes.com)Data Relay: Exotic Propulsion— Thanks to Ben McPheron for researching and presenting this topic. — twitter.com/bdmcpheron — benjaminmcpheron.com — youtube.com/DMExplains— Ion drives (wikipedia.org) — Electrostatic (theorbitalmechanics.com) — Electrothermal (PDF: nap.edu) — Electromagnetic (wikipedia.org)— Photonic sails — Proposed mission to use Sol as a gravitational lens (PDF via archive.org: spaceroutes.com) — Related: Magnetic sail (onlinelibrary.wiley.com) (PDF: usra.edu) — IKAROS (esa.int)— Nuclear thermal engines — Open Cycle (projectrho.com) — Pulsed NTR (aiaa.org)— Nuclear fusion (space.com) — PuFF (Pulsed Fission-Fusion) (nasa.gov)— Laser powered Ion Drive (nasa.gov)— Mach Effect drive (nasa.gov)

If you enjoyed this podcast, make sure to subscribe for more weekly education content from ASCO University. We truly value your feedback and suggestions, so please take a moment to leave a review. If you are an oncology professional and interested in contributing to the ASCO University Weekly Podcast, email ascou@asco.org for more information. TRANSCRIPT The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. [MUSIC PLAYING] Hello and welcome to the ASCO Guidelines podcast series. My name is Shannon McKernin and today I'm interviewing Dr. Valerie de Haas from Princess Máxima Center for Pediatric Oncology in the Netherlands, lead author on "Initial Diagnostic Workup of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the CAP and ASH Guideline.” Thank you for being here today, Dr. de Haas. Thank you. So first, can you give us a general overview of what this guideline covers? Well, yes. The laboratory evaluation of patients who are suspected of having acute leukemia is very complex, and it has evolved significantly with the incorporation of advanced laboratory techniques. The traditional backbone of initial workup of AL, of acute leukemia, is composed of ctyomorphology, cytochemistry, immunophenotyping, and molecular cytogenetics. These techniques are the backbone of the initial diagnostic workup of acute leukemia. This is leading to risk stratification and fine tuning of the therapy by molecular signatures. The advanced molecular diagnostics, such as next-generation sequencing, has become more important in the diagnosis and in the risk stratification of acute leukemia. This guideline is meant for both pediatric and adult patients, and it was initially published in 2017. This year, we reviewed this guideline, and we have taken into account two important developments. First, since 2017, we've seen that there are major advances in molecular techniques and also that we can identify and validate new molecular markers. And those two events have contribute to a better risk stratification. And the second development is the effect that the WHO classification was revised in 2017 which also has led to new risk recoveries and refined subclassifications. So what are the key recommendations of this guideline? Well, in total, we have reviewed 27 guideline statements by the ASCO endorsement expert panelists. And discussion points are used to summarize issues that were identified from the updated literature. The ASCO expert panel determined that the recommendations from the guideline as published in 2016 are clear, thorough, and they are based upon the most relevant scientific evidences. We fully endorse the CAP-ASH guideline on initial diagnostic workup of acute leukemia. And we decided to include some discussion points according to clinical practice and according to the updated literature. In fact, we identified four categories of key recommendations. The first one is the initial diagnostics focusing on basic diagnostics and determination of risk parameters. This concerns, in total, about 11 guideline recommendations, and they give an overview of the initial workup varying from the collection of the clinical history of the patient to initial basic diagnostics by cytomorphology, flow cytometry and molecular cytogenetic analysis of peripheral blood, bone marrow, and cerebrospinal fluids. Secondly, the second category were molecular markers and MRD detection, and they were addressed by 10 of the recommendations. And these recommendations give a structural overview of the molecular and cytogenetic workup for acute lymphoblastic leukemia versus acute myeloid leukemia identifying different prognostic markers. Also, the detection of MRD is taken into account in this recommendation. There is a major difference between children and adults, and this part is given most attention in the discussion part as the developments have been major during the past few years. The third one is the context of referral to another institution with expertise in the management of acute leukemia. This is addressed by four recommendations, emphasizing the point that referral to an institution with specific expertise is of major importance for the central workup of acute leukemia. And finally, the final reporting and report keeping is reflected in three recommendations, mainly supporting conclusions from 2017 which were describing the fact that the complete report with basic diagnostics in one central report should be available within 48 to 72 hours. And this should be followed by complete, final, comprehensive report in one or two weeks. So can you tell us about those discussion points that were made and why the panel decided to include these? The discussion points include mostly issues regarding diagnostics that involve flow cytometry and molecular techniques as addressed in part one and two of the guidelines. We think that the cytomorphologic assessment is essential for initial diagnosis of acute leukemia. Multicolor flow cytometry using 8 to 10 colors has led to a better distinction between myeloids, lymphoid, and mixed lineage blast origin. Even when the number of cells are limited, for instance in CNS involvement, fine needle aspirate of extramedullary leukemic infiltration, or skin biopsy for leukemic cutis. Also, it was suggested to better assess the central nervous system involved in leukemia. The expert panel recommends the immunophenotyping studies as an additional detection technique next to the cytomorphological examination of cytospins and particularly for those with a low level involvement of acute leukemia that cannot be well addressed by a morphologic examination only. The TDT immunohistochemistry staining of cytospins has alternatively been used for detection of CNS disease in AML and evaluation of CSF by multicolor flow cytometry has been recently adopted in some centers. Flow cytometry, using at least six, but we now use in some laboratories, even 8 to 10 colors has led to a much more specific in tentative diagnosis. And this has improved the detection of CNS involvement. The use of molecular tools, for instance, polymerase change reaction, PCR, NGS for low-level CSF involvement is still under study, and therefore, we did not recommend this in our discussion. Regarding the molecular markers and MRD detection, the discussion here was mainly based upon the results of translational research supported by better molecular detection techniques. And those molecular diagnoses have been developing in the past few years with the inclusion of many more molecular markers. And they included one of the key diagnostic criteria in the revised WHO classification, which was revised in 2017. And we made substantial changes that have been made in the ASH-CAP guidelines concerning molecular diagnostics. Those newly identified targets by advanced molecular techniques give possibilities for better risk stratification. Some examples of better molecular characterization of acute lymphoblastic leukemia are, for instance, additional testing for MLL translocations. Furthermore, we can look in patients with T-ALL for NOTCH1, and FBXW7 mutations. The Ikaros family zinc finger gene, the IKZF1 gene is frequently deleted in adults as well in children with B-ALL. And it was shown to have an independent prognostic significance and was also associated with poor clinical outcome. In the current text of the current risk that the protocols IKZF1 should be regularly included in the screening panels for all ALL patients. If we look for examples for better characterization of AML, acute myeloid leukemia, we have found an increasing number of additional cytogenetic aberrations, like for instance FLT3 ITD which is associated with poor outcome. Another example is appropriate mutational analysis for kids, which can be detected both in adult patient as pediatric patients with a confirmed core binding factor acute myeloid leukemia. So this is myeloid leukemia with a translocation A21, RUNX1, or inversion 16. This recommendation is very strong in adults, whereas in children, this prognostic fact impact remains unclear. So there have been proven several publications which refer to a similar prognosis for children and others who refer to a poor prognosis in comparison to known mutated genes. So we suggest to test for this mutation in adults, especially, but also in children to learn from it. Finally, emerging evidence supports molecular studies as principle test for monitoring minimal residual disease of acute leukemia. And there are several key molecular markers that are included in the initial workup, which will be carried on for monitoring MRD, for instance, PML- RAR-alpha, RUNX1-RUNXT1, CBFB-MYH11, and NPM1, CEBP-alpha and others. Beside those aforementioned markers, it's very important to screen for other molecular markers that have predictive or prognostic value in the individual. And it is possible to use them for MRD. We have found a recent consensus from the European Leukemia Net MRD Working Group, who was proposing that for detection of molecular MRD, and they refer the RT PCR platform to NGS and digital PCR platforms. Although all those molecular techniques have been developed very quickly and it is very tempting to use them for initial diagnostics, currently, not all laboratories will have all those techniques available. So the expert panel strongly advises understanding to make distinction between diagnostic that are needed in the first phase to start treatment and subsequently, treatment stratification, in contrast to the usual dose findings in a broader research. For instance, available karyotyping, FISH, PCR techniques, if possible, NGS can be used in the initial start of treatment, whereas techniques like whole exome sequencing, whole genome sequencing, RNA sequencing, and epigenomic studies are meant for a broader research. And finally, how will these guideline recommendations affect patients? Well, in the end, the patients will receive better and especially, more personalized treatment. If we have results available within two weeks from diagnosis, it will be possible to better identify which basis will better benefit from more intensified and more personalized treatment, whereas others may need less intensive treatment with less toxicity. If you use traditional techniques to do this supported by molecular techniques like karyotyping, FISH, and PCR techniques, and in the end, following MRD to see which patients are responding to treatment, MRD detection will help to identify these patients and stratify them finally to the best treatment. Great. Thank you for your work on this important guideline, and thank you for your time today, Dr. de Haas. OK. Thanks a lot. And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast series. 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我的科幻广播剧《太阳帆》播出后，收到的最多的问题就是“太阳帆船”到底如何减速呢？在广播剧中，孙教授只是简单说了一句与海上帆船的原理差不多，没有做更多的解释。实际上，在我写小说的第一版中，我是给减速的原理做了大量的解释，但是最后我又删除了。因为毕竟这还是一个科幻小说，不是科普文章，这样大段大段的技术阐述会大大降低广播剧的节奏感，肯定会丢失很多听众，毕竟，真正关心这种技术细节的听众还是少之又少的。所以我最后决定删除，一笔带过。但是在我的听众中，对此好奇的人真的不少，很多人都来私信质疑太阳帆船能够在太空中不借助燃料减速。那么，今天这期问答，我就来详细说说这个问题。在解释这个问题之前，我们要先建立一个基本概念，任何在太阳系中飞行的物体，都会受到太阳的引力牵引，因此，只要物体的飞行速度不超过第三宇宙速度，那么，这个物体的飞行路线最终一定是围绕着太阳的一个闭合的椭圆形，你可以想象成一个长周期彗星的轨道。好了，有了这个基本概念后，你就会理解，太阳帆船在飞向火星的过程中，它走的飞行路线可不是像太阳射出来的光线那样，直指火星。而像是太阳甩出来的一根抛物线逐渐远离太阳，和阳光的方向始终有一个夹角。现在，我们假设有一艘太阳帆船是沿着这样一条路线飞行，你可以点开本期文稿，看一下示意图： 我们姑且把沿着这条路线飞行的太阳帆船称之为沿着“西北”方向飞，这没毛病吧？在宇宙空间中，方向都是对称的，没有什么方向是特殊的，这也好理解吧。那么，现在我们假设有另外一艘太阳帆船是沿着“东北”方向飞的，我也画了一张示意图：这是不是也没有毛病，你总不至于认为太阳帆船只能沿着某一个固定的方向飞吧。好了，下面就是关键点了，请你想象一下，有一艘向着“西北”方向飞的太阳帆船，它把太阳帆与太阳的相对角度调节到与向着“东北”方向飞的那艘太阳帆船一致，会发生什么情况？我也画了一张示意图，帮助你理解，可以点开本期文稿查看：这时候，这艘太阳帆船的速度方向依然是“西北”，但是加速度的方向却逆转成了“东北”，所以，对于这艘太阳帆船来说，实际的效果就是减速。速度和加速度都是一种矢量单位，它们都是有方向的。有些同学在一开始思考这个问题的时候，容易掉进一个很麻烦的坑，就是去画太阳帆的受力方向和运动方向，这当然最终也能得出正确的结论，但是过程会很绕，一不小心就掉进坑里出不来。而用我上面这个思路，你不要去考虑太阳帆朝向哪里，你只思考比这个更基本的原理，这样就容易理解多了。还有一位听众想不通另外一个问题，太阳帆船在太空中飞行的时候，它的动能是始终在增加的，这没有错。如果减速，就意味着动能减少了，那么根据能量守恒定律，这部分动能必定要转移到其他物质上。如果是一艘有燃料的工质飞船，很好理解，飞船的动能转移到了喷射出的工质上了。但是，太阳帆船这些减少的动能跑到哪里去了呢？答案是动能转移到太阳风了，准确地说是转移到太阳吹出来的那些有质量的粒子上去了。另外，我这里需要特别说明的是，太阳帆实际上一个比较模糊的统称，如果按照工作原理来分的话，其实应该分成三种。第一种叫光子帆，它利用光压来驱动；第二种叫电动帆，是利用太阳风中带正电的质子流来驱动；第三种叫做磁化帆，它利用太阳风中的带电粒子流来驱动。这三种帆的工作原理是不同的，能够从太阳光或者风中获得的推力也是不同的。我的这篇小说有意模糊了太阳帆的概念，我隐含的意思是，小说中的太阳帆船可以同时利用这三种效应来驱动，这也是为什么太阳耀斑爆发可以让印度队获得额外动力的原因。当然，现实世界中，不管是日本还是美国的太阳帆实验，都是只能采用其中某一种驱动方式，无法实现混合动力。但科幻嘛，就可以想象的大胆一点了。世界上第一艘成功发射的太阳帆船是日本在 2010 年 5 月发射的伊卡洛斯号（Ikaros），这是一艘光子帆飞船，帆的面积是 200 平方米，飞行速度到达了 100米/秒，也就是时速 360 公里，跟高铁差不多。美国宇航局也在 2010 年底试验了一种太阳帆，代号是纳米帆-D（NanoSail-D）,这个帆就更小了，面积只有大约10平方米，携带的航天器重量大约4千克，是在地球近地轨道上测试的。当时，美国宇航局为了引起公众的注意，还特地举办了一次摄影比赛，奖金 500 美元，鼓励大家在地面上拍摄近地轨道上展开的太阳帆。我给广播剧下集的封面用的就是这张太阳帆的设计图。不知道大家能不能从小说中推算出来我给这次比赛设定的大致时间，其实，我在写这篇小说的背景设定时，我设定的比赛时间是 2049 年，也就是中华人民共和国成立 100 周年的时候，所以，我必须让中国队赢啊。在做今天的这期节目之前，大家在广播剧下面的留言我全部都浏览了一遍。我捡几个有代表性的留言谈谈我作为作者的一些想法。很多人都提到了这篇小说听上去有点主旋律、正能量，似乎有点那种厉害了我的国的味道，这种感觉好像也引起了一些人的不悦。这我完全可以理解，因为我本人其实也比较反感大跃进和放卫星的，有时候看到官媒过分夸大我国的科技成就，也会起些鸡皮疙瘩，因为有科学精神的人都是有求真精神的人，喜欢实事求是。但是，大家别忘了，我这篇小说是一篇科幻小说，描写的是未来的事情，科幻小说只是在展现未来的某种可能性。回想一下 30 年前的中国，我们为什么不敢想 30 年后的中国能够成为科技第一强国呢？换句话说，这篇科幻小说只是代表了我个人的一种美好愿望，并不是在吹捧我国现在的科技实力。还有好几个留言都谈到了最后的着陆似乎不太可能，或者说缺少一些细节。这里我补充一下，在我写第一稿的时候，我在太阳帆折叠以及二次展开方面是花了不少笔墨的。在我的设想中是这样，太阳帆先是收缩折叠成一个圆锥形，就像蚕茧一样包裹住太空船，大头朝着火星，可以绝热，也可以起到部分减速的功能。到了火星上空 2 万米的时候，太阳帆以非常快的速度再次展开成降落伞的形状。我先是把这部分解说放在了孙教授的台词中，但又觉得实在太啰嗦，就又改为了旁白。但是，左看右看，还是觉得这个地方如果出旁白，势必要渐弱背景音乐的音量，这就会让那种高潮的感觉降低，有让听众出戏的风险。因此，最后权衡利弊，还是删除了这块的细节描写，就逼着五月用音效来帮我搞定。最后这段高潮，五月快被我折磨死了，让他一遍一遍地修改，bgm 不知道换了多少首。最后的效果我还是很满意的，很有画面感，我自己听了不下 10 遍，还没听腻呢。顺便说一句，五月的那种执着精神真的也是没谁了，为了给加布洛夫和日尔科夫穿宇航服、减压、打开舱门、出舱这几个动作找合适的音效，五月说单单是一个减压的音效他就找了 3 个小时，才终于找到一个合适的。我记得上一部戏，五月为了一个摔杯子的音效，自己真的摔了三个玻璃杯才满意。还有一位听众说这部小说中，中国不遵守传统规则，重新解释规则，还让原本的规则没得说，这个世界观不高级。对此，我是不太同意这个观点的，首先，小说中至少有两次明确提到，大赛的规则定的是飞船与火星的距离保持恒定算做抵达终点。这个规则用这么绕口的方式来制定，本身就已经说明了，规则的制定者相当于是明确告诉了所有参赛国家，要么泊入火星轨道，要么就着陆，这根本就不存在别人想不到，就中国人想得到的问题，这又不是什么很绕弯子的事情，太容易想到了。在小说中，印度队的阿米尔不暇思索地就说：难道他们想在火星着陆。我写这句话就已经在告诉观众，着陆这个选项是人人都知道有的。并且从大赛规则的制定者来说，还鼓励这种方式。因为这个比赛的最终目的是为了促进人类宇航技术的发展，着陆显然是要比泊入轨道更加困难，也吃力不讨好的行为，要知道火星同步轨道距离火星还有 2 万多公里呢，换句话说，要着陆，不但要冒着坠毁的风险，还要多飞 2 万多公里。这根本不是什么取巧，这是迎难而上。我相信，如果这种事情真的发生，全世界没有人会认为中国人是在取巧，只会为中国取得的科技成就点赞。这就好像马拉多纳明明可以远射破门，但他偏偏选择了绕过守门员，将球带入球门，如果你看到这样的比赛，会苛责马拉多纳是取巧吗？取巧的前提是，你做的那个行为没什么技术含量，我们只要想到了也能做，那才叫取巧，中国队的这个胜利方式那是标标准准的靠实力取胜，何来的巧呢？还有听众留言问，美国人怎么才能把加布洛夫给救上去。限于篇幅，我在小说中就没有详细描写救援过程，只是虚写了一下。实际上，我当时构思小说的时候，也是仔细考虑过救援的过程的。我设想的过程是这样，首先，美国队要精确测定加布洛夫的飞行速度，然后把自己飞船的飞行速度尽可能地控制到比加布洛夫稍快一点点，让飞船相对于加布洛夫缓缓飘过。因为飞船和加布洛夫都没有动力，所以这种营救机会只有一次成功才行，错过了就永远错过了，因此是非常非常困难的。然后，美国队需要有一名宇航员系上缆绳，穿上宇航服，提前出舱，当然，如果把宇航服描写的有一点点动力会好一点，但也可以写成宇航服没有动力装置，这也合理，因为比赛用的太阳帆船要尽可能减少质量。不管怎么说，美国人要提前出舱，张开双臂，在飞船飘过加布洛夫的时候，一把抱住他，然后再拽着缆绳慢慢回去。注意，只有一次机会，假如没抱住，飞船是不可能再掉头了。在太空中可不是在水中，还可以游一把，指尖一旦分开，那就是只能眼睁睁地看着分开了，不论你怎么动都没用的。当然，这里如果想写的戏剧性一点，其实也可以玩一点小花招，比如，让加布洛夫在自己的宇航服上扎一个洞，通过放气来获得一点点动力，让分开的手再次抓住，当然，如果气放光了还没抓住，人也就死了。如果拍电影的话，想让观众屏住呼吸，制造紧张感，就可以这么写，在千钧一发之际，终于回到了飞船船舱。我看还有人质疑说，太阳帆船不可能多设计一个人的座位，怎么能挤进三个人。这个就真的是多虑了，在这种生存还是死亡的极端情况下，飞船中硬挤进一个人不是什么不可以想象的事情。看过冯小刚的电影《手机》吗？一辆五人座的轿车不是硬挤进去 12 个人吗？飞船再怎么节省空间，也不可能一个人的空间也多不出来的。其实，连食物和水都不是什么大问题，2个人的食物分给3个人吃，是饿不死的。真正的大问题 是我在小说中提到的，2个人的氧气3个人用，这才是大问题，因为人类无法控制氧气的消耗量，所以，我才需要让他们去找最近的太空坞寻求救援。好了，不管怎么说，都非常感谢大家提出来的宝贵意见，吐槽和被吐槽其实都是蛮有乐趣的，写科幻就是开脑洞，幻想的本来就不是真实发生过的事情，有槽点我觉得很正常。说实话，我自己还没看过哪篇科幻小说在逻辑性和科学性上都是完美的，总能找到一些槽点的。你们替我找bug，我尽量去补漏，这种攻防是一种很有意思的脑力游戏，我也乐此不疲。同时，你们的这些意见也可以帮助我完善这篇小说，说不定，还真有哪个影视公司看上这篇小说，愿意拍成科幻电影呢，那就更需要在意各种细节了。

我的科幻广播剧《太阳帆》播出后，收到的最多的问题就是“太阳帆船”到底如何减速呢？在广播剧中，孙教授只是简单说了一句与海上帆船的原理差不多，没有做更多的解释。实际上，在我写小说的第一版中，我是给减速的原理做了大量的解释，但是最后我又删除了。因为毕竟这还是一个科幻小说，不是科普文章，这样大段大段的技术阐述会大大降低广播剧的节奏感，肯定会丢失很多听众，毕竟，真正关心这种技术细节的听众还是少之又少的。所以我最后决定删除，一笔带过。但是在我的听众中，对此好奇的人真的不少，很多人都来私信质疑太阳帆船能够在太空中不借助燃料减速。那么，今天这期问答，我就来详细说说这个问题。在解释这个问题之前，我们要先建立一个基本概念，任何在太阳系中飞行的物体，都会受到太阳的引力牵引，因此，只要物体的飞行速度不超过第三宇宙速度，那么，这个物体的飞行路线最终一定是围绕着太阳的一个闭合的椭圆形，你可以想象成一个长周期彗星的轨道。好了，有了这个基本概念后，你就会理解，太阳帆船在飞向火星的过程中，它走的飞行路线可不是像太阳射出来的光线那样，直指火星。而像是太阳甩出来的一根抛物线逐渐远离太阳，和阳光的方向始终有一个夹角。现在，我们假设有一艘太阳帆船是沿着这样一条路线飞行，你可以点开本期文稿，看一下示意图： 我们姑且把沿着这条路线飞行的太阳帆船称之为沿着“西北”方向飞，这没毛病吧？在宇宙空间中，方向都是对称的，没有什么方向是特殊的，这也好理解吧。那么，现在我们假设有另外一艘太阳帆船是沿着“东北”方向飞的，我也画了一张示意图：这是不是也没有毛病，你总不至于认为太阳帆船只能沿着某一个固定的方向飞吧。好了，下面就是关键点了，请你想象一下，有一艘向着“西北”方向飞的太阳帆船，它把太阳帆与太阳的相对角度调节到与向着“东北”方向飞的那艘太阳帆船一致，会发生什么情况？我也画了一张示意图，帮助你理解，可以点开本期文稿查看：这时候，这艘太阳帆船的速度方向依然是“西北”，但是加速度的方向却逆转成了“东北”，所以，对于这艘太阳帆船来说，实际的效果就是减速。速度和加速度都是一种矢量单位，它们都是有方向的。有些同学在一开始思考这个问题的时候，容易掉进一个很麻烦的坑，就是去画太阳帆的受力方向和运动方向，这当然最终也能得出正确的结论，但是过程会很绕，一不小心就掉进坑里出不来。而用我上面这个思路，你不要去考虑太阳帆朝向哪里，你只思考比这个更基本的原理，这样就容易理解多了。还有一位听众想不通另外一个问题，太阳帆船在太空中飞行的时候，它的动能是始终在增加的，这没有错。如果减速，就意味着动能减少了，那么根据能量守恒定律，这部分动能必定要转移到其他物质上。如果是一艘有燃料的工质飞船，很好理解，飞船的动能转移到了喷射出的工质上了。但是，太阳帆船这些减少的动能跑到哪里去了呢？答案是动能转移到太阳风了，准确地说是转移到太阳吹出来的那些有质量的粒子上去了。另外，我这里需要特别说明的是，太阳帆实际上一个比较模糊的统称，如果按照工作原理来分的话，其实应该分成三种。第一种叫光子帆，它利用光压来驱动；第二种叫电动帆，是利用太阳风中带正电的质子流来驱动；第三种叫做磁化帆，它利用太阳风中的带电粒子流来驱动。这三种帆的工作原理是不同的，能够从太阳光或者风中获得的推力也是不同的。我的这篇小说有意模糊了太阳帆的概念，我隐含的意思是，小说中的太阳帆船可以同时利用这三种效应来驱动，这也是为什么太阳耀斑爆发可以让印度队获得额外动力的原因。当然，现实世界中，不管是日本还是美国的太阳帆实验，都是只能采用其中某一种驱动方式，无法实现混合动力。但科幻嘛，就可以想象的大胆一点了。世界上第一艘成功发射的太阳帆船是日本在 2010 年 5 月发射的伊卡洛斯号（Ikaros），这是一艘光子帆飞船，帆的面积是 200 平方米，飞行速度到达了 100米/秒，也就是时速 360 公里，跟高铁差不多。美国宇航局也在 2010 年底试验了一种太阳帆，代号是纳米帆-D（NanoSail-D）,这个帆就更小了，面积只有大约10平方米，携带的航天器重量大约4千克，是在地球近地轨道上测试的。当时，美国宇航局为了引起公众的注意，还特地举办了一次摄影比赛，奖金 500 美元，鼓励大家在地面上拍摄近地轨道上展开的太阳帆。我给广播剧下集的封面用的就是这张太阳帆的设计图。不知道大家能不能从小说中推算出来我给这次比赛设定的大致时间，其实，我在写这篇小说的背景设定时，我设定的比赛时间是 2049 年，也就是中华人民共和国成立 100 周年的时候，所以，我必须让中国队赢啊。在做今天的这期节目之前，大家在广播剧下面的留言我全部都浏览了一遍。我捡几个有代表性的留言谈谈我作为作者的一些想法。很多人都提到了这篇小说听上去有点主旋律、正能量，似乎有点那种厉害了我的国的味道，这种感觉好像也引起了一些人的不悦。这我完全可以理解，因为我本人其实也比较反感大跃进和放卫星的，有时候看到官媒过分夸大我国的科技成就，也会起些鸡皮疙瘩，因为有科学精神的人都是有求真精神的人，喜欢实事求是。但是，大家别忘了，我这篇小说是一篇科幻小说，描写的是未来的事情，科幻小说只是在展现未来的某种可能性。回想一下 30 年前的中国，我们为什么不敢想 30 年后的中国能够成为科技第一强国呢？换句话说，这篇科幻小说只是代表了我个人的一种美好愿望，并不是在吹捧我国现在的科技实力。还有好几个留言都谈到了最后的着陆似乎不太可能，或者说缺少一些细节。这里我补充一下，在我写第一稿的时候，我在太阳帆折叠以及二次展开方面是花了不少笔墨的。在我的设想中是这样，太阳帆先是收缩折叠成一个圆锥形，就像蚕茧一样包裹住太空船，大头朝着火星，可以绝热，也可以起到部分减速的功能。到了火星上空 2 万米的时候，太阳帆以非常快的速度再次展开成降落伞的形状。我先是把这部分解说放在了孙教授的台词中，但又觉得实在太啰嗦，就又改为了旁白。但是，左看右看，还是觉得这个地方如果出旁白，势必要渐弱背景音乐的音量，这就会让那种高潮的感觉降低，有让听众出戏的风险。因此，最后权衡利弊，还是删除了这块的细节描写，就逼着五月用音效来帮我搞定。最后这段高潮，五月快被我折磨死了，让他一遍一遍地修改，bgm 不知道换了多少首。最后的效果我还是很满意的，很有画面感，我自己听了不下 10 遍，还没听腻呢。顺便说一句，五月的那种执着精神真的也是没谁了，为了给加布洛夫和日尔科夫穿宇航服、减压、打开舱门、出舱这几个动作找合适的音效，五月说单单是一个减压的音效他就找了 3 个小时，才终于找到一个合适的。我记得上一部戏，五月为了一个摔杯子的音效，自己真的摔了三个玻璃杯才满意。还有一位听众说这部小说中，中国不遵守传统规则，重新解释规则，还让原本的规则没得说，这个世界观不高级。对此，我是不太同意这个观点的，首先，小说中至少有两次明确提到，大赛的规则定的是飞船与火星的距离保持恒定算做抵达终点。这个规则用这么绕口的方式来制定，本身就已经说明了，规则的制定者相当于是明确告诉了所有参赛国家，要么泊入火星轨道，要么就着陆，这根本就不存在别人想不到，就中国人想得到的问题，这又不是什么很绕弯子的事情，太容易想到了。在小说中，印度队的阿米尔不暇思索地就说：难道他们想在火星着陆。我写这句话就已经在告诉观众，着陆这个选项是人人都知道有的。并且从大赛规则的制定者来说，还鼓励这种方式。因为这个比赛的最终目的是为了促进人类宇航技术的发展，着陆显然是要比泊入轨道更加困难，也吃力不讨好的行为，要知道火星同步轨道距离火星还有 2 万多公里呢，换句话说，要着陆，不但要冒着坠毁的风险，还要多飞 2 万多公里。这根本不是什么取巧，这是迎难而上。我相信，如果这种事情真的发生，全世界没有人会认为中国人是在取巧，只会为中国取得的科技成就点赞。这就好像马拉多纳明明可以远射破门，但他偏偏选择了绕过守门员，将球带入球门，如果你看到这样的比赛，会苛责马拉多纳是取巧吗？取巧的前提是，你做的那个行为没什么技术含量，我们只要想到了也能做，那才叫取巧，中国队的这个胜利方式那是标标准准的靠实力取胜，何来的巧呢？还有听众留言问，美国人怎么才能把加布洛夫给救上去。限于篇幅，我在小说中就没有详细描写救援过程，只是虚写了一下。实际上，我当时构思小说的时候，也是仔细考虑过救援的过程的。我设想的过程是这样，首先，美国队要精确测定加布洛夫的飞行速度，然后把自己飞船的飞行速度尽可能地控制到比加布洛夫稍快一点点，让飞船相对于加布洛夫缓缓飘过。因为飞船和加布洛夫都没有动力，所以这种营救机会只有一次成功才行，错过了就永远错过了，因此是非常非常困难的。然后，美国队需要有一名宇航员系上缆绳，穿上宇航服，提前出舱，当然，如果把宇航服描写的有一点点动力会好一点，但也可以写成宇航服没有动力装置，这也合理，因为比赛用的太阳帆船要尽可能减少质量。不管怎么说，美国人要提前出舱，张开双臂，在飞船飘过加布洛夫的时候，一把抱住他，然后再拽着缆绳慢慢回去。注意，只有一次机会，假如没抱住，飞船是不可能再掉头了。在太空中可不是在水中，还可以游一把，指尖一旦分开，那就是只能眼睁睁地看着分开了，不论你怎么动都没用的。当然，这里如果想写的戏剧性一点，其实也可以玩一点小花招，比如，让加布洛夫在自己的宇航服上扎一个洞，通过放气来获得一点点动力，让分开的手再次抓住，当然，如果气放光了还没抓住，人也就死了。如果拍电影的话，想让观众屏住呼吸，制造紧张感，就可以这么写，在千钧一发之际，终于回到了飞船船舱。我看还有人质疑说，太阳帆船不可能多设计一个人的座位，怎么能挤进三个人。这个就真的是多虑了，在这种生存还是死亡的极端情况下，飞船中硬挤进一个人不是什么不可以想象的事情。看过冯小刚的电影《手机》吗？一辆五人座的轿车不是硬挤进去 12 个人吗？飞船再怎么节省空间，也不可能一个人的空间也多不出来的。其实，连食物和水都不是什么大问题，2个人的食物分给3个人吃，是饿不死的。真正的大问题 是我在小说中提到的，2个人的氧气3个人用，这才是大问题，因为人类无法控制氧气的消耗量，所以，我才需要让他们去找最近的太空坞寻求救援。好了，不管怎么说，都非常感谢大家提出来的宝贵意见，吐槽和被吐槽其实都是蛮有乐趣的，写科幻就是开脑洞，幻想的本来就不是真实发生过的事情，有槽点我觉得很正常。说实话，我自己还没看过哪篇科幻小说在逻辑性和科学性上都是完美的，总能找到一些槽点的。你们替我找bug，我尽量去补漏，这种攻防是一种很有意思的脑力游戏，我也乐此不疲。同时，你们的这些意见也可以帮助我完善这篇小说，说不定，还真有哪个影视公司看上这篇小说，愿意拍成科幻电影呢，那就更需要在意各种细节了。

我的科幻广播剧《太阳帆》播出后，收到的最多的问题就是“太阳帆船”到底如何减速呢？在广播剧中，孙教授只是简单说了一句与海上帆船的原理差不多，没有做更多的解释。实际上，在我写小说的第一版中，我是给减速的原理做了大量的解释，但是最后我又删除了。因为毕竟这还是一个科幻小说，不是科普文章，这样大段大段的技术阐述会大大降低广播剧的节奏感，肯定会丢失很多听众，毕竟，真正关心这种技术细节的听众还是少之又少的。所以我最后决定删除，一笔带过。但是在我的听众中，对此好奇的人真的不少，很多人都来私信质疑太阳帆船能够在太空中不借助燃料减速。那么，今天这期问答，我就来详细说说这个问题。在解释这个问题之前，我们要先建立一个基本概念，任何在太阳系中飞行的物体，都会受到太阳的引力牵引，因此，只要物体的飞行速度不超过第三宇宙速度，那么，这个物体的飞行路线最终一定是围绕着太阳的一个闭合的椭圆形，你可以想象成一个长周期彗星的轨道。好了，有了这个基本概念后，你就会理解，太阳帆船在飞向火星的过程中，它走的飞行路线可不是像太阳射出来的光线那样，直指火星。而像是太阳甩出来的一根抛物线逐渐远离太阳，和阳光的方向始终有一个夹角。现在，我们假设有一艘太阳帆船是沿着这样一条路线飞行，你可以点开本期文稿，看一下示意图： 我们姑且把沿着这条路线飞行的太阳帆船称之为沿着“西北”方向飞，这没毛病吧？在宇宙空间中，方向都是对称的，没有什么方向是特殊的，这也好理解吧。那么，现在我们假设有另外一艘太阳帆船是沿着“东北”方向飞的，我也画了一张示意图：这是不是也没有毛病，你总不至于认为太阳帆船只能沿着某一个固定的方向飞吧。好了，下面就是关键点了，请你想象一下，有一艘向着“西北”方向飞的太阳帆船，它把太阳帆与太阳的相对角度调节到与向着“东北”方向飞的那艘太阳帆船一致，会发生什么情况？我也画了一张示意图，帮助你理解，可以点开本期文稿查看：这时候，这艘太阳帆船的速度方向依然是“西北”，但是加速度的方向却逆转成了“东北”，所以，对于这艘太阳帆船来说，实际的效果就是减速。速度和加速度都是一种矢量单位，它们都是有方向的。有些同学在一开始思考这个问题的时候，容易掉进一个很麻烦的坑，就是去画太阳帆的受力方向和运动方向，这当然最终也能得出正确的结论，但是过程会很绕，一不小心就掉进坑里出不来。而用我上面这个思路，你不要去考虑太阳帆朝向哪里，你只思考比这个更基本的原理，这样就容易理解多了。还有一位听众想不通另外一个问题，太阳帆船在太空中飞行的时候，它的动能是始终在增加的，这没有错。如果减速，就意味着动能减少了，那么根据能量守恒定律，这部分动能必定要转移到其他物质上。如果是一艘有燃料的工质飞船，很好理解，飞船的动能转移到了喷射出的工质上了。但是，太阳帆船这些减少的动能跑到哪里去了呢？答案是动能转移到太阳风了，准确地说是转移到太阳吹出来的那些有质量的粒子上去了。另外，我这里需要特别说明的是，太阳帆实际上一个比较模糊的统称，如果按照工作原理来分的话，其实应该分成三种。第一种叫光子帆，它利用光压来驱动；第二种叫电动帆，是利用太阳风中带正电的质子流来驱动；第三种叫做磁化帆，它利用太阳风中的带电粒子流来驱动。这三种帆的工作原理是不同的，能够从太阳光或者风中获得的推力也是不同的。我的这篇小说有意模糊了太阳帆的概念，我隐含的意思是，小说中的太阳帆船可以同时利用这三种效应来驱动，这也是为什么太阳耀斑爆发可以让印度队获得额外动力的原因。当然，现实世界中，不管是日本还是美国的太阳帆实验，都是只能采用其中某一种驱动方式，无法实现混合动力。但科幻嘛，就可以想象的大胆一点了。世界上第一艘成功发射的太阳帆船是日本在 2010 年 5 月发射的伊卡洛斯号（Ikaros），这是一艘光子帆飞船，帆的面积是 200 平方米，飞行速度到达了 100米/秒，也就是时速 360 公里，跟高铁差不多。美国宇航局也在 2010 年底试验了一种太阳帆，代号是纳米帆-D（NanoSail-D）,这个帆就更小了，面积只有大约10平方米，携带的航天器重量大约4千克，是在地球近地轨道上测试的。当时，美国宇航局为了引起公众的注意，还特地举办了一次摄影比赛，奖金 500 美元，鼓励大家在地面上拍摄近地轨道上展开的太阳帆。我给广播剧下集的封面用的就是这张太阳帆的设计图。不知道大家能不能从小说中推算出来我给这次比赛设定的大致时间，其实，我在写这篇小说的背景设定时，我设定的比赛时间是 2049 年，也就是中华人民共和国成立 100 周年的时候，所以，我必须让中国队赢啊。在做今天的这期节目之前，大家在广播剧下面的留言我全部都浏览了一遍。我捡几个有代表性的留言谈谈我作为作者的一些想法。很多人都提到了这篇小说听上去有点主旋律、正能量，似乎有点那种厉害了我的国的味道，这种感觉好像也引起了一些人的不悦。这我完全可以理解，因为我本人其实也比较反感大跃进和放卫星的，有时候看到官媒过分夸大我国的科技成就，也会起些鸡皮疙瘩，因为有科学精神的人都是有求真精神的人，喜欢实事求是。但是，大家别忘了，我这篇小说是一篇科幻小说，描写的是未来的事情，科幻小说只是在展现未来的某种可能性。回想一下 30 年前的中国，我们为什么不敢想 30 年后的中国能够成为科技第一强国呢？换句话说，这篇科幻小说只是代表了我个人的一种美好愿望，并不是在吹捧我国现在的科技实力。还有好几个留言都谈到了最后的着陆似乎不太可能，或者说缺少一些细节。这里我补充一下，在我写第一稿的时候，我在太阳帆折叠以及二次展开方面是花了不少笔墨的。在我的设想中是这样，太阳帆先是收缩折叠成一个圆锥形，就像蚕茧一样包裹住太空船，大头朝着火星，可以绝热，也可以起到部分减速的功能。到了火星上空 2 万米的时候，太阳帆以非常快的速度再次展开成降落伞的形状。我先是把这部分解说放在了孙教授的台词中，但又觉得实在太啰嗦，就又改为了旁白。但是，左看右看，还是觉得这个地方如果出旁白，势必要渐弱背景音乐的音量，这就会让那种高潮的感觉降低，有让听众出戏的风险。因此，最后权衡利弊，还是删除了这块的细节描写，就逼着五月用音效来帮我搞定。最后这段高潮，五月快被我折磨死了，让他一遍一遍地修改，bgm 不知道换了多少首。最后的效果我还是很满意的，很有画面感，我自己听了不下 10 遍，还没听腻呢。顺便说一句，五月的那种执着精神真的也是没谁了，为了给加布洛夫和日尔科夫穿宇航服、减压、打开舱门、出舱这几个动作找合适的音效，五月说单单是一个减压的音效他就找了 3 个小时，才终于找到一个合适的。我记得上一部戏，五月为了一个摔杯子的音效，自己真的摔了三个玻璃杯才满意。还有一位听众说这部小说中，中国不遵守传统规则，重新解释规则，还让原本的规则没得说，这个世界观不高级。对此，我是不太同意这个观点的，首先，小说中至少有两次明确提到，大赛的规则定的是飞船与火星的距离保持恒定算做抵达终点。这个规则用这么绕口的方式来制定，本身就已经说明了，规则的制定者相当于是明确告诉了所有参赛国家，要么泊入火星轨道，要么就着陆，这根本就不存在别人想不到，就中国人想得到的问题，这又不是什么很绕弯子的事情，太容易想到了。在小说中，印度队的阿米尔不暇思索地就说：难道他们想在火星着陆。我写这句话就已经在告诉观众，着陆这个选项是人人都知道有的。并且从大赛规则的制定者来说，还鼓励这种方式。因为这个比赛的最终目的是为了促进人类宇航技术的发展，着陆显然是要比泊入轨道更加困难，也吃力不讨好的行为，要知道火星同步轨道距离火星还有 2 万多公里呢，换句话说，要着陆，不但要冒着坠毁的风险，还要多飞 2 万多公里。这根本不是什么取巧，这是迎难而上。我相信，如果这种事情真的发生，全世界没有人会认为中国人是在取巧，只会为中国取得的科技成就点赞。这就好像马拉多纳明明可以远射破门，但他偏偏选择了绕过守门员，将球带入球门，如果你看到这样的比赛，会苛责马拉多纳是取巧吗？取巧的前提是，你做的那个行为没什么技术含量，我们只要想到了也能做，那才叫取巧，中国队的这个胜利方式那是标标准准的靠实力取胜，何来的巧呢？还有听众留言问，美国人怎么才能把加布洛夫给救上去。限于篇幅，我在小说中就没有详细描写救援过程，只是虚写了一下。实际上，我当时构思小说的时候，也是仔细考虑过救援的过程的。我设想的过程是这样，首先，美国队要精确测定加布洛夫的飞行速度，然后把自己飞船的飞行速度尽可能地控制到比加布洛夫稍快一点点，让飞船相对于加布洛夫缓缓飘过。因为飞船和加布洛夫都没有动力，所以这种营救机会只有一次成功才行，错过了就永远错过了，因此是非常非常困难的。然后，美国队需要有一名宇航员系上缆绳，穿上宇航服，提前出舱，当然，如果把宇航服描写的有一点点动力会好一点，但也可以写成宇航服没有动力装置，这也合理，因为比赛用的太阳帆船要尽可能减少质量。不管怎么说，美国人要提前出舱，张开双臂，在飞船飘过加布洛夫的时候，一把抱住他，然后再拽着缆绳慢慢回去。注意，只有一次机会，假如没抱住，飞船是不可能再掉头了。在太空中可不是在水中，还可以游一把，指尖一旦分开，那就是只能眼睁睁地看着分开了，不论你怎么动都没用的。当然，这里如果想写的戏剧性一点，其实也可以玩一点小花招，比如，让加布洛夫在自己的宇航服上扎一个洞，通过放气来获得一点点动力，让分开的手再次抓住，当然，如果气放光了还没抓住，人也就死了。如果拍电影的话，想让观众屏住呼吸，制造紧张感，就可以这么写，在千钧一发之际，终于回到了飞船船舱。我看还有人质疑说，太阳帆船不可能多设计一个人的座位，怎么能挤进三个人。这个就真的是多虑了，在这种生存还是死亡的极端情况下，飞船中硬挤进一个人不是什么不可以想象的事情。看过冯小刚的电影《手机》吗？一辆五人座的轿车不是硬挤进去 12 个人吗？飞船再怎么节省空间，也不可能一个人的空间也多不出来的。其实，连食物和水都不是什么大问题，2个人的食物分给3个人吃，是饿不死的。真正的大问题 是我在小说中提到的，2个人的氧气3个人用，这才是大问题，因为人类无法控制氧气的消耗量，所以，我才需要让他们去找最近的太空坞寻求救援。好了，不管怎么说，都非常感谢大家提出来的宝贵意见，吐槽和被吐槽其实都是蛮有乐趣的，写科幻就是开脑洞，幻想的本来就不是真实发生过的事情，有槽点我觉得很正常。说实话，我自己还没看过哪篇科幻小说在逻辑性和科学性上都是完美的，总能找到一些槽点的。你们替我找bug，我尽量去补漏，这种攻防是一种很有意思的脑力游戏，我也乐此不疲。同时，你们的这些意见也可以帮助我完善这篇小说，说不定，还真有哪个影视公司看上这篇小说，愿意拍成科幻电影呢，那就更需要在意各种细节了。

我的科幻广播剧《太阳帆》播出后，收到的最多的问题就是“太阳帆船”到底如何减速呢？在广播剧中，孙教授只是简单说了一句与海上帆船的原理差不多，没有做更多的解释。实际上，在我写小说的第一版中，我是给减速的原理做了大量的解释，但是最后我又删除了。因为毕竟这还是一个科幻小说，不是科普文章，这样大段大段的技术阐述会大大降低广播剧的节奏感，肯定会丢失很多听众，毕竟，真正关心这种技术细节的听众还是少之又少的。所以我最后决定删除，一笔带过。但是在我的听众中，对此好奇的人真的不少，很多人都来私信质疑太阳帆船能够在太空中不借助燃料减速。那么，今天这期问答，我就来详细说说这个问题。在解释这个问题之前，我们要先建立一个基本概念，任何在太阳系中飞行的物体，都会受到太阳的引力牵引，因此，只要物体的飞行速度不超过第三宇宙速度，那么，这个物体的飞行路线最终一定是围绕着太阳的一个闭合的椭圆形，你可以想象成一个长周期彗星的轨道。好了，有了这个基本概念后，你就会理解，太阳帆船在飞向火星的过程中，它走的飞行路线可不是像太阳射出来的光线那样，直指火星。而像是太阳甩出来的一根抛物线逐渐远离太阳，和阳光的方向始终有一个夹角。现在，我们假设有一艘太阳帆船是沿着这样一条路线飞行，你可以点开本期文稿，看一下示意图： 我们姑且把沿着这条路线飞行的太阳帆船称之为沿着“西北”方向飞，这没毛病吧？在宇宙空间中，方向都是对称的，没有什么方向是特殊的，这也好理解吧。那么，现在我们假设有另外一艘太阳帆船是沿着“东北”方向飞的，我也画了一张示意图：这是不是也没有毛病，你总不至于认为太阳帆船只能沿着某一个固定的方向飞吧。好了，下面就是关键点了，请你想象一下，有一艘向着“西北”方向飞的太阳帆船，它把太阳帆与太阳的相对角度调节到与向着“东北”方向飞的那艘太阳帆船一致，会发生什么情况？我也画了一张示意图，帮助你理解，可以点开本期文稿查看：这时候，这艘太阳帆船的速度方向依然是“西北”，但是加速度的方向却逆转成了“东北”，所以，对于这艘太阳帆船来说，实际的效果就是减速。速度和加速度都是一种矢量单位，它们都是有方向的。有些同学在一开始思考这个问题的时候，容易掉进一个很麻烦的坑，就是去画太阳帆的受力方向和运动方向，这当然最终也能得出正确的结论，但是过程会很绕，一不小心就掉进坑里出不来。而用我上面这个思路，你不要去考虑太阳帆朝向哪里，你只思考比这个更基本的原理，这样就容易理解多了。还有一位听众想不通另外一个问题，太阳帆船在太空中飞行的时候，它的动能是始终在增加的，这没有错。如果减速，就意味着动能减少了，那么根据能量守恒定律，这部分动能必定要转移到其他物质上。如果是一艘有燃料的工质飞船，很好理解，飞船的动能转移到了喷射出的工质上了。但是，太阳帆船这些减少的动能跑到哪里去了呢？答案是动能转移到太阳风了，准确地说是转移到太阳吹出来的那些有质量的粒子上去了。另外，我这里需要特别说明的是，太阳帆实际上一个比较模糊的统称，如果按照工作原理来分的话，其实应该分成三种。第一种叫光子帆，它利用光压来驱动；第二种叫电动帆，是利用太阳风中带正电的质子流来驱动；第三种叫做磁化帆，它利用太阳风中的带电粒子流来驱动。这三种帆的工作原理是不同的，能够从太阳光或者风中获得的推力也是不同的。我的这篇小说有意模糊了太阳帆的概念，我隐含的意思是，小说中的太阳帆船可以同时利用这三种效应来驱动，这也是为什么太阳耀斑爆发可以让印度队获得额外动力的原因。当然，现实世界中，不管是日本还是美国的太阳帆实验，都是只能采用其中某一种驱动方式，无法实现混合动力。但科幻嘛，就可以想象的大胆一点了。世界上第一艘成功发射的太阳帆船是日本在 2010 年 5 月发射的伊卡洛斯号（Ikaros），这是一艘光子帆飞船，帆的面积是 200 平方米，飞行速度到达了 100米/秒，也就是时速 360 公里，跟高铁差不多。美国宇航局也在 2010 年底试验了一种太阳帆，代号是纳米帆-D（NanoSail-D）,这个帆就更小了，面积只有大约10平方米，携带的航天器重量大约4千克，是在地球近地轨道上测试的。当时，美国宇航局为了引起公众的注意，还特地举办了一次摄影比赛，奖金 500 美元，鼓励大家在地面上拍摄近地轨道上展开的太阳帆。我给广播剧下集的封面用的就是这张太阳帆的设计图。不知道大家能不能从小说中推算出来我给这次比赛设定的大致时间，其实，我在写这篇小说的背景设定时，我设定的比赛时间是 2049 年，也就是中华人民共和国成立 100 周年的时候，所以，我必须让中国队赢啊。在做今天的这期节目之前，大家在广播剧下面的留言我全部都浏览了一遍。我捡几个有代表性的留言谈谈我作为作者的一些想法。很多人都提到了这篇小说听上去有点主旋律、正能量，似乎有点那种厉害了我的国的味道，这种感觉好像也引起了一些人的不悦。这我完全可以理解，因为我本人其实也比较反感大跃进和放卫星的，有时候看到官媒过分夸大我国的科技成就，也会起些鸡皮疙瘩，因为有科学精神的人都是有求真精神的人，喜欢实事求是。但是，大家别忘了，我这篇小说是一篇科幻小说，描写的是未来的事情，科幻小说只是在展现未来的某种可能性。回想一下 30 年前的中国，我们为什么不敢想 30 年后的中国能够成为科技第一强国呢？换句话说，这篇科幻小说只是代表了我个人的一种美好愿望，并不是在吹捧我国现在的科技实力。还有好几个留言都谈到了最后的着陆似乎不太可能，或者说缺少一些细节。这里我补充一下，在我写第一稿的时候，我在太阳帆折叠以及二次展开方面是花了不少笔墨的。在我的设想中是这样，太阳帆先是收缩折叠成一个圆锥形，就像蚕茧一样包裹住太空船，大头朝着火星，可以绝热，也可以起到部分减速的功能。到了火星上空 2 万米的时候，太阳帆以非常快的速度再次展开成降落伞的形状。我先是把这部分解说放在了孙教授的台词中，但又觉得实在太啰嗦，就又改为了旁白。但是，左看右看，还是觉得这个地方如果出旁白，势必要渐弱背景音乐的音量，这就会让那种高潮的感觉降低，有让听众出戏的风险。因此，最后权衡利弊，还是删除了这块的细节描写，就逼着五月用音效来帮我搞定。最后这段高潮，五月快被我折磨死了，让他一遍一遍地修改，bgm 不知道换了多少首。最后的效果我还是很满意的，很有画面感，我自己听了不下 10 遍，还没听腻呢。顺便说一句，五月的那种执着精神真的也是没谁了，为了给加布洛夫和日尔科夫穿宇航服、减压、打开舱门、出舱这几个动作找合适的音效，五月说单单是一个减压的音效他就找了 3 个小时，才终于找到一个合适的。我记得上一部戏，五月为了一个摔杯子的音效，自己真的摔了三个玻璃杯才满意。还有一位听众说这部小说中，中国不遵守传统规则，重新解释规则，还让原本的规则没得说，这个世界观不高级。对此，我是不太同意这个观点的，首先，小说中至少有两次明确提到，大赛的规则定的是飞船与火星的距离保持恒定算做抵达终点。这个规则用这么绕口的方式来制定，本身就已经说明了，规则的制定者相当于是明确告诉了所有参赛国家，要么泊入火星轨道，要么就着陆，这根本就不存在别人想不到，就中国人想得到的问题，这又不是什么很绕弯子的事情，太容易想到了。在小说中，印度队的阿米尔不暇思索地就说：难道他们想在火星着陆。我写这句话就已经在告诉观众，着陆这个选项是人人都知道有的。并且从大赛规则的制定者来说，还鼓励这种方式。因为这个比赛的最终目的是为了促进人类宇航技术的发展，着陆显然是要比泊入轨道更加困难，也吃力不讨好的行为，要知道火星同步轨道距离火星还有 2 万多公里呢，换句话说，要着陆，不但要冒着坠毁的风险，还要多飞 2 万多公里。这根本不是什么取巧，这是迎难而上。我相信，如果这种事情真的发生，全世界没有人会认为中国人是在取巧，只会为中国取得的科技成就点赞。这就好像马拉多纳明明可以远射破门，但他偏偏选择了绕过守门员，将球带入球门，如果你看到这样的比赛，会苛责马拉多纳是取巧吗？取巧的前提是，你做的那个行为没什么技术含量，我们只要想到了也能做，那才叫取巧，中国队的这个胜利方式那是标标准准的靠实力取胜，何来的巧呢？还有听众留言问，美国人怎么才能把加布洛夫给救上去。限于篇幅，我在小说中就没有详细描写救援过程，只是虚写了一下。实际上，我当时构思小说的时候，也是仔细考虑过救援的过程的。我设想的过程是这样，首先，美国队要精确测定加布洛夫的飞行速度，然后把自己飞船的飞行速度尽可能地控制到比加布洛夫稍快一点点，让飞船相对于加布洛夫缓缓飘过。因为飞船和加布洛夫都没有动力，所以这种营救机会只有一次成功才行，错过了就永远错过了，因此是非常非常困难的。然后，美国队需要有一名宇航员系上缆绳，穿上宇航服，提前出舱，当然，如果把宇航服描写的有一点点动力会好一点，但也可以写成宇航服没有动力装置，这也合理，因为比赛用的太阳帆船要尽可能减少质量。不管怎么说，美国人要提前出舱，张开双臂，在飞船飘过加布洛夫的时候，一把抱住他，然后再拽着缆绳慢慢回去。注意，只有一次机会，假如没抱住，飞船是不可能再掉头了。在太空中可不是在水中，还可以游一把，指尖一旦分开，那就是只能眼睁睁地看着分开了，不论你怎么动都没用的。当然，这里如果想写的戏剧性一点，其实也可以玩一点小花招，比如，让加布洛夫在自己的宇航服上扎一个洞，通过放气来获得一点点动力，让分开的手再次抓住，当然，如果气放光了还没抓住，人也就死了。如果拍电影的话，想让观众屏住呼吸，制造紧张感，就可以这么写，在千钧一发之际，终于回到了飞船船舱。我看还有人质疑说，太阳帆船不可能多设计一个人的座位，怎么能挤进三个人。这个就真的是多虑了，在这种生存还是死亡的极端情况下，飞船中硬挤进一个人不是什么不可以想象的事情。看过冯小刚的电影《手机》吗？一辆五人座的轿车不是硬挤进去 12 个人吗？飞船再怎么节省空间，也不可能一个人的空间也多不出来的。其实，连食物和水都不是什么大问题，2个人的食物分给3个人吃，是饿不死的。真正的大问题 是我在小说中提到的，2个人的氧气3个人用，这才是大问题，因为人类无法控制氧气的消耗量，所以，我才需要让他们去找最近的太空坞寻求救援。好了，不管怎么说，都非常感谢大家提出来的宝贵意见，吐槽和被吐槽其实都是蛮有乐趣的，写科幻就是开脑洞，幻想的本来就不是真实发生过的事情，有槽点我觉得很正常。说实话，我自己还没看过哪篇科幻小说在逻辑性和科学性上都是完美的，总能找到一些槽点的。你们替我找bug，我尽量去补漏，这种攻防是一种很有意思的脑力游戏，我也乐此不疲。同时，你们的这些意见也可以帮助我完善这篇小说，说不定，还真有哪个影视公司看上这篇小说，愿意拍成科幻电影呢，那就更需要在意各种细节了。

The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. [MUSIC PLAYING] Hello and welcome to the ASCO Guidelines podcast series. My name is Shannon McKernin and today I'm interviewing Dr. Valerie de Haas from Princess Máxima Center for Pediatric Oncology in the Netherlands, lead author on "Initial Diagnostic Workup of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the CAP and ASH Guideline.” Thank you for being here today, Dr. de Haas. Thank you. So first, can you give us a general overview of what this guideline covers? Well, yes. The laboratory evaluation of patients who are suspected of having acute leukemia is very complex, and it has evolved significantly with the incorporation of advanced laboratory techniques. The traditional backbone of initial workup of AL, of acute leukemia, is composed of ctyomorphology, cytochemistry, immunophenotyping, and molecular cytogenetics. These techniques are the backbone of the initial diagnostic workup of acute leukemia. This is leading to risk stratification and fine tuning of the therapy by molecular signatures. The advanced molecular diagnostics, such as next-generation sequencing, has become more important in the diagnosis and in the risk stratification of acute leukemia. This guideline is meant for both pediatric and adult patients, and it was initially published in 2017. This year, we reviewed this guideline, and we have taken into account two important developments. First, since 2017, we've seen that there are major advances in molecular techniques and also that we can identify and validate new molecular markers. And those two events have contribute to a better risk stratification. And the second development is the effect that the WHO classification was revised in 2017 which also has led to new risk recoveries and refined subclassifications. So what are the key recommendations of this guideline? Well, in total, we have reviewed 27 guideline statements by the ASCO endorsement expert panelists. And discussion points are used to summarize issues that were identified from the updated literature. The ASCO expert panel determined that the recommendations from the guideline as published in 2016 are clear, thorough, and they are based upon the most relevant scientific evidences. We fully endorse the CAP-ASH guideline on initial diagnostic workup of acute leukemia. And we decided to include some discussion points according to clinical practice and according to the updated literature. In fact, we identified four categories of key recommendations. The first one is the initial diagnostics focusing on basic diagnostics and determination of risk parameters. This concerns, in total, about 11 guideline recommendations, and they give an overview of the initial workup varying from the collection of the clinical history of the patient to initial basic diagnostics by cytomorphology, flow cytometry and molecular cytogenetic analysis of peripheral blood, bone marrow, and cerebrospinal fluids. Secondly, the second category were molecular markers and MRD detection, and they were addressed by 10 of the recommendations. And these recommendations give a structural overview of the molecular and cytogenetic workup for acute lymphoblastic leukemia versus acute myeloid leukemia identifying different prognostic markers. Also, the detection of MRD is taken into account in this recommendation. There is a major difference between children and adults, and this part is given most attention in the discussion part as the developments have been major during the past few years. The third one is the context of referral to another institution with expertise in the management of acute leukemia. This is addressed by four recommendations, emphasizing the point that referral to an institution with specific expertise is of major importance for the central workup of acute leukemia. And finally, the final reporting and report keeping is reflected in three recommendations, mainly supporting conclusions from 2017 which were describing the fact that the complete report with basic diagnostics in one central report should be available within 48 to 72 hours. And this should be followed by complete, final, comprehensive report in one or two weeks. So can you tell us about those discussion points that were made and why the panel decided to include these? The discussion points include mostly issues regarding diagnostics that involve flow cytometry and molecular techniques as addressed in part one and two of the guidelines. We think that the cytomorphologic assessment is essential for initial diagnosis of acute leukemia. Multicolor flow cytometry using 8 to 10 colors has led to a better distinction between myeloids, lymphoid, and mixed lineage blast origin. Even when the number of cells are limited, for instance in CNS involvement, fine needle aspirate of extramedullary leukemic infiltration, or skin biopsy for leukemic cutis. Also, it was suggested to better assess the central nervous system involved in leukemia. The expert panel recommends the immunophenotyping studies as an additional detection technique next to the cytomorphological examination of cytospins and particularly for those with a low level involvement of acute leukemia that cannot be well addressed by a morphologic examination only. The TDT immunohistochemistry staining of cytospins has alternatively been used for detection of CNS disease in AML and evaluation of CSF by multicolor flow cytometry has been recently adopted in some centers. Flow cytometry, using at least six, but we now use in some laboratories, even 8 to 10 colors has led to a much more specific in tentative diagnosis. And this has improved the detection of CNS involvement. The use of molecular tools, for instance, polymerase change reaction, PCR, NGS for low-level CSF involvement is still under study, and therefore, we did not recommend this in our discussion. Regarding the molecular markers and MRD detection, the discussion here was mainly based upon the results of translational research supported by better molecular detection techniques. And those molecular diagnoses have been developing in the past few years with the inclusion of many more molecular markers. And they included one of the key diagnostic criteria in the revised WHO classification, which was revised in 2017. And we made substantial changes that have been made in the ASH-CAP guidelines concerning molecular diagnostics. Those newly identified targets by advanced molecular techniques give possibilities for better risk stratification. Some examples of better molecular characterization of acute lymphoblastic leukemia are, for instance, additional testing for MLL translocations. Furthermore, we can look in patients with T-ALL for NOTCH1, and FBXW7 mutations. The Ikaros family zinc finger gene, the IKZF1 gene is frequently deleted in adults as well in children with B-ALL. And it was shown to have an independent prognostic significance and was also associated with poor clinical outcome. In the current text of the current risk that the protocols IKZF1 should be regularly included in the screening panels for all ALL patients. If we look for examples for better characterization of AML, acute myeloid leukemia, we have found an increasing number of additional cytogenetic aberrations, like for instance FLT3 ITD which is associated with poor outcome. Another example is appropriate mutational analysis for kids, which can be detected both in adult patient as pediatric patients with a confirmed core binding factor acute myeloid leukemia. So this is myeloid leukemia with a translocation A21, RUNX1, or inversion 16. This recommendation is very strong in adults, whereas in children, this prognostic fact impact remains unclear. So there have been proven several publications which refer to a similar prognosis for children and others who refer to a poor prognosis in comparison to known mutated genes. So we suggest to test for this mutation in adults, especially, but also in children to learn from it. Finally, emerging evidence supports molecular studies as principle test for monitoring minimal residual disease of acute leukemia. And there are several key molecular markers that are included in the initial workup, which will be carried on for monitoring MRD, for instance, PML- RAR-alpha, RUNX1-RUNXT1, CBFB-MYH11, and NPM1, CEBP-alpha and others. Beside those aforementioned markers, it's very important to screen for other molecular markers that have predictive or prognostic value in the individual. And it is possible to use them for MRD. We have found a recent consensus from the European Leukemia Net MRD Working Group, who was proposing that for detection of molecular MRD, and they refer the RT PCR platform to NGS and digital PCR platforms. Although all those molecular techniques have been developed very quickly and it is very tempting to use them for initial diagnostics, currently, not all laboratories will have all those techniques available. So the expert panel strongly advises understanding to make distinction between diagnostic that are needed in the first phase to start treatment and subsequently, treatment stratification, in contrast to the usual dose findings in a broader research. For instance, available karyotyping, FISH, PCR techniques, if possible, NGS can be used in the initial start of treatment, whereas techniques like whole exome sequencing, whole genome sequencing, RNA sequencing, and epigenomic studies are meant for a broader research. And finally, how will these guideline recommendations affect patients? Well, in the end, the patients will receive better and especially, more personalized treatment. If we have results available within two weeks from diagnosis, it will be possible to better identify which basis will better benefit from more intensified and more personalized treatment, whereas others may need less intensive treatment with less toxicity. If you use traditional techniques to do this supported by molecular techniques like karyotyping, FISH, and PCR techniques, and in the end, following MRD to see which patients are responding to treatment, MRD detection will help to identify these patients and stratify them finally to the best treatment. Great. Thank you for your work on this important guideline, and thank you for your time today, Dr. de Haas. OK. Thanks a lot. And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast series. If you've enjoyed what you've heard today, please rate and review the podcast and refer this show to a colleague.

De svenskägda spelbolagen på Malta säger sig alla värna om spelmissbrukarna men hur ser det ut i praktiken? Casinomiljarderna granska en skrupulös svensk miljardindustri. Från 2016. Bortanför svensk lagstiftning arbetar över fem tusen svenskar inom spelindustrin i det lilla skatteparadiset Malta, för svenskägda företag som Betsson, Mr Green och LeoVegas. De säger sig alla ha en paradgren: ansvarstagande gentemot de svenskar som har problem att hantera sitt spelande. Allra längst anses Unibet ha kommit de har utvecklat ett avancerat datasystem som kan känna av när spelare är på väg att bli destruktiva.  Så varför blir ingenjören Jonatan uppringd av Unibet när hans spelmissbruk eskalerar? Varför bjuder spelbolaget honom på lyxresa till London? Dokumentären Casinomiljarderna ger sig in i en värld där stenhård marknadsföring och bonussystem satts i system även mot de mest utsatta.   Måns Mosesson har utöver P1 Dokumentär bland annat arbetat för Ekot, gjort P3 Dokumentärer och skrivit för Dagens Nyheter och Sydsvenskan. 2014 vann han Stora journalistpriset för P1 Dokumentär-serien Rädda Sverige och 2012 tilldelades hans P1 Dokumentär Gå till jobbet och dö en Ikaros för Årets bästa reportage samt Susanne Björkman-stipendiet.

This time on Anime Hatewatch! A panty obsessed high school student gets an angel-robot-slave dropped on him from the sky, because anime. The angel-robot-slave can basically grant any wishes, but doesn't have any emotions, and wants to learn what love is. You know, because anime. Listen in as we discuss this hot slave being genre gem in this installment of: ANIME HATEWATCH!   If you like us, please share us with your friends. We do not pay to advertise. Don't forget to subscribe to us on iTunes, and while you're there give us a rating. We really appreciate it!   Check out Bloodletter at the following links: Facebook Bandcamp

A cosa serve la scienza di base? a parte l'ovvia risposta "assolutamente a nulla", le ricadute sono molteplici... ce ne parla Valeria in una intervista a Giovanni Porcellana, che si occupa di trasferimento tecnologico al CERN. Giovanni ci spiega come tecnologie sviluppate per la scienza di base possano trovare applicazioni in campo artistico e in campo medico, come per l'adroterapia o per la recentissima (e bellissima) prima radiografia a colori di un corpo umano. Senza dimenticare che anche il world wide web è nato grazie al CERN...Parliamo poi di stelle, partendo dalla notizia di un pianeta orfano della sua stella, che ci dà lo spunto per raccontare qualcosa sulla dinamica dell'evoluzione stellare e sulla classificazione in base al colore.Chiudiamo rimanendo in argomento astronomico, rispondendo alla domanda di un ascoltatore sulla sonda IKAROS della JAXA: come fa un "veliero solare" come questa piccola sonda ad andare verso il Sole?Navigando di bolina anche noi verso le ferie vi diamo appuntamento al prossimo episodio!

Ett nytt avsnitt av Cinema Celsius är här, som idag bl.a. bjuder på en dos rövarspråk... Men i vanlig ordning snackas det naturligtvis film också och den här gången recenserar vi den omtalade doping-dokumentären "Icarus" (eller "Ikaros" som den kallas på svenska). Vi avslutar sedan med en ordentlig trailerkoll där vi spånar om "The Shape of Water", "Hostiles" och The Greatest Showman". Trevlig lyssning!

Dr Churchman speaks with ecancertv at ASH 2016 about the mutations in IKZF1, or Ikaros, that are associated with worse outcomes for childhood leukaemia. She outlines a suite of heritable mutations which result in a stem-like behaviour, cell adhesion and drug resistance within the bone marrow. Dr Churchman explains how next generation sequencing could help in identifying patients most suited to targeted therapy.

This week's roundtable episode features a (mostly) silent co-host: Ikaros the official Glitch HQ office doge! While not distracted by adorableness, Martha gives a primer on Git and version control best practices, Stephen leads a discussion on art direction, and Mark tries to understand PC gamers. Feedback Form GLITCHCON Celebrates A Weekend Of Gaming - Troy Strand , Tech {dot} MN Version Control 0:03:58 Martha Megarry Category Production Tools Git Martha's Git workshop presentation slides - Martha Megarry A Short History of Git - git SourceTree GItKraken “Merging Unity scenes, prefabs and assets with git” - David Douglas Git for Unity Developers - Alistair Doulin GitHub Bitbucket Heroku "Pushing to multiple git repos" - Alex Armstrong Code School: Learn Git - Paolo Perrotta , Code School Art Direction 0:33:38 Stephen McGregor Category Art In our episode " Bananas from here to eternity" the third topic in the roundtable is on Developer Art "Bananas, from here to eternity." "The Design Bible Behind New York City’s Subway Republished as a Limited-Editio… - Kristin Hohenadel , Slate SPY Fox Series Mini-Games Behind Borderlands' 11th-hour style change - Tor Thorsen Civ V Art Director Explains Art Deco Look - Adam Biessener , Game Informer Animation Bootcamp: Cuphead Process and Philosophy - Jake Clark , GDC Vault Console vs PC Development 0:54:44 Mark LaCroix Category Hardware Book Review: The Art of Game Design - Daniel Cook Valve making big changes to Steam's trading card economy - Derek Strickland , Tweak Town Sony Developer Program Xbox LIVE Creator's program ID@XBOX Becoming a Nintendo Switch indie dev will be tough early on - Kris Graft

Vi snakker om tanker og mindfulness og Ikaros. Tony står tidligt op og Henrik koncentrerer sig kun om sig selv. I baggrunden står Jesus og Svend Brinkmann og kommer med gode råd.

De svenskägda spelbolagen på Malta säger sig alla värna om spelmissbrukarna men hur ser det ut i praktiken? Casinomiljarderna fortsätter att granska en omstridd svensk miljardindustri. Från 2016. Bortanför svensk lagstiftning arbetar över fem tusen svenskar inom spelindustrin i det lilla skatteparadiset Malta, för svenskägda företag som Betsson, Mr Green och LeoVegas.De säger sig alla ha en paradgren: ansvarstagande gentemot de svenskar som har problem att hantera sitt spelande. Allra längst anses Unibet ha kommit de har utvecklat ett avancerat datasystem som kan känna av när spelare är på väg att bli destruktiva. Så varför blir ingenjören Jonatan uppringd av Unibet när hans spelmissbruk eskalerar? Varför bjuder spelbolaget honom på lyxresa till London?Den andra delen av Casinomiljarderna ger sig in i en värld där stenhård marknadsföring och bonussystem satts i system även mot de mest utsatta.  Måns Mosesson har utöver P1 Dokumentär bland annat arbetat för Ekot, gjort P3 Dokumentärer och skrivit för Dagens Nyheter och Sydsvenskan. 2014 vann han Stora journalistpriset för P1 Dokumentär-serien Rädda Sverige och 2012 tilldelades hans P1 Dokumentär Gå till jobbet och dö en Ikaros för Årets bästa reportage samt Susanne Björkman-stipendiet.

Det finns en ny typ av svenska miljardärer som blivit som förmögna på människans dröm om att bli rik. Casinomiljarderna granskar en hemlighetsfull bransch i skatteparadiset Malta. Från 2016. När internet började bli populärt fick travfantasten Anders Ström en idé: den som först erbjuder spel om pengar på nätet kommer att bli mycket framgångsrik och förmögen.Casinomiljarderna är historien om hur han använder sina egna spelvinster från travet till att kringgå det svenska spelmonopolet och rulla igång en svensk miljardindustri i skatteparadiset Malta.Numera är det över fem tusen svenskar som jobbar med spel på den lilla ön i Medelhavet ­ de arbetar för företag som Betsson, Mr. Green, Leovegas och Unibet. Bolag som riktar sig till svenska spelare, men inte omfattas av svensk lag och undkommer svensk skatt.På kundtjänsten hos Casumo jobbar Pavel Ouvin, som har fått syn på hur lättledda och impulsiva människor är ­ nu vill han starta eget och bli nästa svenska casinomiljardär.Reportern Måns Mosesson är flerfaldigt belönad för sina radioreportage. 2014 vann han Stora journalistpriset samt Prix Italia för P1 Dokumentär-serien Rädda Sverige  och 2012 tilldelades hans P1 Dokumentär Gå till jobbet och dö en Ikaros för Årets bästa reportage, samt Susanne Björkman-stipendiet.

Den 30 augusti 2012 försvinner affärsmannen Kjell Gustafsson. Polisen står handfallen. Inte ett spår finns efter Kjell. Först två år senare får gåtan sin lösning. I en liten by i södra Sverige växer två ungdomar upp. Måns och Susanne. En gammal fejd mellan de båda ungdomarnas släkter gör att Susannes pappa Kjell inte har mycket till övers för Måns. Men Susanne trotsar Kjell och väljer att bli tillsammans med Måns.Kjell äger gårdar, skog, fastigheter och företag. När dottern som ska förvalta arvet nu väljer Måns ser Kjell sitt livsverk hotat och motarbetar förhållandet.Under sensommaren 2012 försvinner Kjell. Misstankar riktas snart mot Måns och Susanne, men polisen saknar bevis. Och mordet på Kjell är på väg att bli det perfekta brottet.Alla inblandade och flera av de vi intervjuat nämns inte vid sina riktiga namn.Vi vill varna för obehagliga inslag i dokumentären.Av Sigrid Edsenius.Producent Robert Barkman.Sigrid Edsenius är reporter på P4 Kalmar, Sveriges Radio. Hon har tidigare gjort P4 dokumentärerna Mormor tyckte Hitler var tjusig, Pingstpastor Åke Green dömd till framgång och den prisbelönade Högsby ett år efter mordet (Ikaros 2006).

De svenskägda spelbolagen på Malta säger sig alla värna om spelmissbrukarna men hur ser det ut i praktiken? Casinomiljarderna fortsätter att granska en omstridd svensk miljardindustri. Bortanför svensk lagstiftning arbetar över fem tusen svenskar inom spelindustrin i det lilla skatteparadiset Malta, för svenskägda företag som Betsson, Mr Green och LeoVegas.De säger sig alla ha en paradgren: ansvarstagande gentemot de svenskar som har problem att hantera sitt spelande. Allra längst anses Unibet ha kommit de har utvecklat ett avancerat datasystem som kan känna av när spelare är på väg att bli destruktiva. Så varför blir ingenjören Jonatan uppringd av Unibet när hans spelmissbruk eskalerar? Varför bjuder spelbolaget honom på lyxresa till London?Den andra delen av Casinomiljarderna ger sig in i en värld där stenhård marknadsföring och bonussystem satts i system även mot de mest utsatta.  Måns Mosesson har utöver P1 Dokumentär bland annat arbetat för Ekot, gjort P3 Dokumentärer och skrivit för Dagens Nyheter och Sydsvenskan. 2014 vann han Stora journalistpriset för P1 Dokumentär-serien Rädda Sverige och 2012 tilldelades hans P1 Dokumentär Gå till jobbet och dö en Ikaros för Årets bästa reportage samt Susanne Björkman-stipendiet.

Det finns en ny typ av svenska miljardärer, som blivit som förmögna på människans dröm om att bli rik. Casinomiljarderna granskar en hemlighetsfull bransch som drivs från skatteparadiset Malta. När internet började bli populärt fick travfantasten Anders Ström en idé: den som först erbjuder spel om pengar på nätet kommer att bli mycket framgångsrik och förmögen.Casinomiljarderna är historien om hur han använder sina egna spelvinster från travet till att kringgå det svenska spelmonopolet och rulla igång en svensk miljardindustri i skatteparadiset Malta.Numera är det över fem tusen svenskar som jobbar med spel på den lilla ön i Medelhavet ­ de arbetar för företag som Betsson, Mr. Green, Leovegas och Unibet. Bolag som riktar sig till svenska spelare, men inte omfattas av svensk lag och undkommer svensk skatt.På kundtjänsten hos Casumo jobbar Pavel Ouvin, som har fått syn på hur lättledda och impulsiva människor är ­ nu vill han starta eget och bli nästa svenska casinomiljardär.Reportern Måns Mosesson är flerfaldigt belönad för sina radioreportage. 2014 vann han Stora journalistpriset samt Prix Italia för P1 Dokumentär-serien Rädda Sverige  och 2012 tilldelades hans P1 Dokumentär Gå till jobbet och dö en Ikaros för Årets bästa reportage, samt Susanne Björkman-stipendiet.

Årets Guldspade. I den andra delen av dokumentären fortsätter Katia Wagner och Milan Djelevic berättelsen om Tobias som i tre år kämpat för att få hem sitt barn från ett familjehem i Bollnäs. Det är ett unikt fall, så till vida att sonens placering på ett familjehem inte handlat om att Tobias förmåga att ta hand om ett barn ifrågasatts. Socialtjänsten har bromsat  en överflyttning från det familjehem pojken bor hos, på grund av att pojken är född för tidigt och enligt myndigheten är stresskänslig. Socialtjänsten har menat att hemflytten måste ske gradvis och långsamt. Pernilla Leviner, doktor i offentlig rätt och expert på social barnrätt, har granskat domarna och delar av utredningsmaterialet. Hon menar att det gick fel redan från början. Lagen ställer väldigt tydligt krav på att det ska vara brister i hemförhållanden, det finns fyra olika kriterier, misshandel, brister i omsorgen, otillbörligt utnyttjandet eller annat förhållande i hemmet. Men i det här fallet var det så att barnet var redan placerat, pappan brast inte, utan bristen blir att han gör en annan bedömning än socialtjänsten om huruvida barnet ska hem eller ej, säger Pernilla Leviner. Socialnämnden gjorde fel när man tvångsomhändertog Tobias son.  Hans "... önskemål om regelbundet och frekvent umgänge med sonen, måste ses som både naturligt och befogat..." Det slår hösta förvaltningsdomstolen fast i en dom idag den 17 juni. Kammarrätten borde inte ha gått på socialnämndens linje, menar den högsta instansen och upphäver beslutet om LVU.  Högsta förvaltningsdomstolen tog upp fallet hösten 2014 och idag kom alltså domen. I den står: Högsta Förvaltningsdomstolen finner till skillnad från kammarätten - att vad som lagts Tobias till last inte kan anses utgöra sådana brister i omsorgen som kan grunda vård med stöd av 2 paragrafen LVU (Lagen om vård av unga). Redan av detta skäl har det brustit i förutsättningarna för tvångsvård. Kammarrätten borde därför inte beslutat om att pojken skulle beredas vård med stöd av LVU. Hela domen hittar ni här Programmet sändes först gången i juni 2015.   Milan Djelevic är reporter på Ekot, SverigesRadio, och har i över två decennier jobbat med undersökande journalistik både inom tryckt press och radio. Han har vunnit Guldspaden, och varit nominerad till Ikaros och Röda Korsets journalistpris. Katia Wagner ärfrilansjournalist och författare till böckerna De förlorade barnen och Alexandramannen. Hon har vunnit Guldspaden och fått Wendelapriset för bästa socialreportage. Producent: Håkan Engström.

Den 30 augusti 2012 försvinner affärsmannen Kjell Gustafsson. Polisen står handfallen. Inte ett spår finns efter Kjell. Först två år senare får gåtan sin lösning. I en liten by i södra Sverige växer två ungdomar upp. Måns och Susanne. En gammal fejd mellan de båda ungdomarnas släkter gör att Susannes pappa Kjell inte har mycket till övers för Måns. Men Susanne trotsar Kjell och väljer att bli tillsammans med Måns. Kjell äger gårdar, skog, fastigheter och företag. När dottern som ska förvalta arvet nu väljer Måns ser Kjell sitt livsverk hotat och motarbetar förhållandet. Under sensommaren 2012 försvinner Kjell. Misstankar riktas snart mot Måns och Susanne, men polisen saknar bevis. Och mordet på Kjell är på väg att bli det perfekta brottet. Alla inblandade och flera av de vi intervjuat nämns inte vid sina riktiga namn. Vi vill varna för obehagliga inslag i dokumentären. Sigrid Edsenius är reporter på P4 Kalmar, Sveriges Radio. Hon har tidigare gjort P4 dokumentärerna ”Mormor tyckte Hitler var tjusig”, ”Pingstpastor Åke Green – dömd till framgång” och den prisbelönade ”Högsby – ett år efter mordet” (Ikaros 2006).

2012 fick 40-årige Tobias från Malmö veta att han har en son. Idag, tre år senare, kämpar han fortfarande för att få hem pojken som är tvångsomhändertagen i Bollnäs 80 mil bort. Barnet placerades i familjehem redan innan det stod klart vem pappan var, på grund av brister hos mamman. Istället för att leta upp den andra biologiska föräldern, folkbokförde socialnämnden i Bollnäs barnet hos ett barnlöst par i 25-årsåldern. De fick veta att pojken sannolikt skulle växa upp hos dem. Det var Tobias själv som fick bekräfta faderskapet genom ett dna-test. Då var sonen redan ett halvår gammal. När han tog kontakt med socialnämnden för att ta hand om sitt barn, fick han veta att pojken för tillfället inte kunde flytta hem. Hans hälsa skulle kunna skadas allvarligt, enligt socialnämnden, eftersom barnet är för tidigt fött och påstods vara extremt känsligt. Tobias valde då att lita på myndigheten, men snart stod det klart att myndigheten istället bromsade en överflyttning. Tobias har spelat in samtal och möten han haft med myndigheter, vilket han också varit öppen med. Journalisterna Katia Wagner och Milan Djelevic har följt honom under ett år. I programmet avslöjar Tobias ljud- och bildinspelningar hur socialnämnden bland annat använder sig av obestyrkta uppgifter för att bromsa överflyttningen till Tobias. Socialnämnden gjorde fel när man tvångsomhändertog Tobias son.  Hans "... önskemål om regelbundet och frekvent umgänge med sonen, måste ses som både naturligt och befogat..." Det slår hösta förvaltningsdomstolen fast i en dom idag den 17 juni. Kammarrätten borde inte ha gått på socialnämndens linje, menar den högsta instansen och upphäver beslutet om LVU.  Högsta förvaltningsdomstolen tog upp fallet hösten 2014 och idag kom alltså domen.  I den står: ”Högsta Förvaltningsdomstolen finner – till skillnad från kammarätten - att vad som lagts Tobias till last inte kan anses utgöra sådana brister i omsorgen som kan grunda vård med stöd av 2 paragrafen LVU (Lagen om vård av unga). Redan av detta skäl har det brustit i förutsättningarna för tvångsvård. Kammarrätten borde därför inte beslutat om att pojken skulle beredas vård med stöd av LVU”. Hela domen hittar ni här: http://www.hogstaforvaltningsdomstolen.se/Domstolar/regeringsratten/Avg%c3%b6randen/2015/Juni/6062-14.pdf   Milan Djelevic är reporter på Ekot, Sveriges Radio och har i över två decennier jobbat med undersökande journalistik både inom tryckt press och radio. Han har varit nominerad till Guldspaden, Ikaros och Röda Korsets journalistpris. Katia Wagner är frilansjournalist och författare till böckerna De förlorade barnen och Alexandramannen. Hon har varit guldspadenominerad 3 gånger, och fått Wendelapriset för bästa socialreportage. Producent: Håkan Engström.

Mittelschüler Tomoki Sakurai interessiert sich für Sex, bevorzugt ansonsten aber ein friedliches Leben. Etwas ungewöhnlich sind nur seine immer wiederkehrenden Träume von einem Mädchen, an dessen Gesicht er sich nicht erinnern kann. Eines Tages steigt das Engelsmädchen Ikaros vom Himmel herab, und Tomokis Begegnung mit ihr ändert sein beschauliches Pennälerleben schlagartig.

Det är tidigt 1960-tal. Nya idéer ligger i luften och framtiden är ljus. Men på Kalmar allmänna läroverk går en gammal man omkring i korridorerna. Han är biologilärare och gör allt för att göra livet surt för de elever som inte passar in i hans världsbild. Han tycker inte om judar. Sigrid Edsenius följer spåren bakåt i tiden för att försöka ta reda på hur läraren kunde få fortsätta att undervisa. På resan upptäcker hon fler som inte gjort upp med det förflutna, även i den egna familjen. Sigrid Edsenius arbetar som journalist på P4 Kalmar Sveriges Radio. 2006 fick hon Public Service-klubbens prestigefyllda pris Ikaros för sin dokumentär om mordet på Abbas Rezai. Hon har även gjort P4 Dokumentären Åke Green – dömd till framgång. sigrid.edsenius@sverigesradio.se

Det är tidigt 1960-tal. Nya idéer ligger i luften och framtiden är ljus. Men på Kalmar allmänna läroverk går en gammal man omkring i korridorerna. Han är biologilärare och gör allt för att göra livet surt för de elever som inte passar in i hans världsbild. Han tycker inte om judar. Sigrid Edsenius följer spåren bakåt i tiden för att försöka ta reda på hur läraren kunde få fortsätta att undervisa. På resan upptäcker hon fler som inte gjort upp med det förflutna, även i den egna familjen. Sigrid Edsenius arbetar som journalist på P4 Kalmar Sveriges Radio. 2006 fick hon Public Service-klubbens prestigefyllda pris Ikaros för sin dokumentär om mordet på Abbas Rezai. Hon har även gjort P4 Dokumentären Åke Green - dömd till framgång. sigrid.edsenius@sverigesradio.se

In today’s episode, I talk to Matthew Witkowski, a PhD student at the Walter and Eliza Hall Institute in Melbourne, on his research into the relationship between the Ikaros Gene and Leukemia. We discuss: – Matt’s background – A definition of leukaemia – Matt’s work in his PhD – What is the Ikaros gene? – […]

Ekstramaterialet i dag forflytter seg litt rundt på huset - først i garderoben, så i treningsrommet og deretter gjennom gangene. På veien møter produsenten folk som han må be om tjenester av ulikt slag. Velbekomme.

Måns Moseson vann en Ikaros! "Gå till jobbet och dö" blev Årets reportage 2013:"För en angelägen och högst levande berättelse om den osynliggjorda död som drabbar arbetare i vårt land varje vecka och som gjorde att Magnus bara blev 28 år, nio månader och 13 dagar" Dokumentären är berättelsen om en av de drygt femtio svenskar som varje år dör på sin arbetsplats. 28-årige Magnus Kärnbo var först ut på järnvägsrälsen den där eftermiddagen, han ville visa framfötterna och se till att stolpen vid spår U2 blev jordad i tid. Istället kom tåget. 2012 tilldelades Måns Mosesson Susanne Björkman-stipendiet för Gå till jobbet och dö i samband med dokumentärkvällen på Kägelbannan på Södra teatern i Stockholm den 10 oktober. Motiveringen löd: För ett engagemang som når bortom den personliga sfären, för beskrivningen av en sällan skildrad verklighet, för konsten att lyfta blicken utan att tappa mark under fötterna och för en lågmäld upprördhet som växer i styrka och som inte går att värja sig emot.

Hur kom det sig att en liten teckning på en hembygdsgård i värmlandskogarna kunde få så oväntade och stora konsekvenser - att en ensam amerikansk kvinna kunde bli indragen i planeringen av ett mord på en svensk medborgare? Sommaren 2007 bestämmer sig den lilla hembygdsgården utanför Karlstad för att ta ner Lars Vilks teckning av profeten Muhammed som rondellhund. Några veckor senare bestämmer sig Nerikes Allehanda för att publicera bilden i en ledarkrönika. Rondellhunden blir plötsligt en världsnyhet när demonstrationer bildas utanför tidningen. Svenska flaggor bränns i Afghanistan. I Pakistan får den svenska regeringen motta en officiell protest och under fredagsbönerna i Islamabad får svenska medborgare och svenska företag hot uttalade mot sig. Några veckor senare kommer fatwan från Al-Qaida. Lars Vilks och chefredaktören på Nerikes Allehanda ska halshuggas. Hotet är uttalad. Frågan ärbara - vem kommer att lyssna?                       I USA sitter samtidigt en ensam arbetslös amerikansk kvinna i den lilla staden Pennsburg.  Hon lever ett parallelliv på internet. Som Jihad Jane, en konverterad muslim. Hon får kontakt med en man i sydöstra Asien. Han ger henne ett uppdrag. Att döda Lars Vilks. Martin Johnson har rest i Jihad Janes fotspår: till USA och pojkvännen som blev lurad och vidare till Irland där komplotten fick ett dramatiskt slut.   Programmet gjordes i samarbete med Ciaran Cassidy, irländsk flerfaldigt internationellt prisbelönt radioproducent och Andy Mills, amerikansk frilansjournalist.    Läs också Martin Johnsons reportage ”En hund begraven” i tidskriften senaste nummer där han berättar mer om komplotten att döda Lars Vilks.   Om Martin Johnson Martin Johnsons senaste dokumentär blev shortlisted i Prix Europa 2011, och var nominerad till Ikaros och Stora Radiopriset. 2007 vann hans dokumentär Pappa tar semester Ikarospriset och det internationellt prestigefyllda Prix Italia.

épisode de test et d'introduction au podcast du groupe d'électro Sergents Ikaros.

小惑星探査機「はやぶさ」の旅を振り返るJAXA提供のラジオ番組「JAXAぼくらの宇宙大冒険」。第8章：「IKAROS」は、世界で初めてソーラーセイルによる航行を達成しました。（2011年2月26日、27日放送）

小惑星探査機「はやぶさ」の旅を振り返るJAXA提供のラジオ番組「JAXAぼくらの宇宙大冒険」。第7章：2010年5月21日、太陽光での宇宙航行を実証するため「IKAROS」が打ち上げられました。（2011年2月19日、20日放送）

El 9 de julio de 2010 asistimos a un logro tecnológico sorprendente, más propio de un relato de ciencia ficción. La sonda espacial IKAROS, de la Agencia Espacial Japonesa (JAXA), tras varias semanas de viaje con destino a Venus, fue el primer vehículo espacial en la historia que consiguió desplegar una gran vela solar para propulsarse en el vacío espacial.

Falcon 9 Launch, Another Jupiter Smackdown, IKAROS...and a SurpriseLearn more about your ad choices. Visit megaphone.fm/adchoices

Planetary Society Executive Director Lou Friedman on solar sails IKAROS and LightSail-1Learn more about your ad choices. Visit megaphone.fm/adchoices

宇宙開発の歴史について学ぶJAXA提供のラジオ番組「JAXAスペースアカデミー」。人工衛星と宇宙が、私たちの暮らしをどう支えているのかについて勉強していきましょう。第6回目は、光の圧力を帆で受けて進む、未来型の宇宙船「ソーラーセイル」の実証機「IKAROS」について学びます。（2010年2月13日放送）

Der menschliche Igl-Enhancer besteht aus den drei DNase I-hypersensitiven Regionen HSS-1, -2 und -3, wobei HSS-3 den eigentlichen Enhancer darstellt und HSS-1 und -2 gemeinsam auf HSS-3 synergistisch wirken. Ziel der vorliegenden Arbeit war es, die B-zellspezifische Region HSS-2 näher einzugrenzen und zu charakterisieren. Dazu wurden transiente Transfektionen und In-vivo-Footprinting-Versuche durchgeführt. Die Transfektionsexperimente erfolgten mit den reifen B-Zelllinien MN60 und Daudi. Dazu wurden Luciferasereportergenkonstrukte mit Punktmutationen in den beiden NFkB-Bindungsstellen von HSS-2 oder mit 5’- bzw. 3’-Deletionen in HSS-2 eingesetzt. Die Auswertung der Daten ergab, daß der Transkriptionsfaktor NFkB eine sehr wichtige Rolle in der Regulierung des humanen Igl-Locus spielt. Die Transkriptionskontrolle durch NFkB erfolgt als Bestandteil von Transkriptionskomplexen unter anderem über die Öffnung des Chromatins, womit die DNA auch für andere Faktoren zugänglich wird. Die anschließenden In-vivo-Footprinting-Versuche sollten Aufschluß über die Proteinbedeckung der genomischen DNA von B-Zellen in HSS-2 geben. Für die Untersuchungen wurden die reifen B-Zelllinien Daudi und MN60, die Prä-B-Zelllinie BV173, die T-Zelllinien Jurkat und CCRF-CEM und die myeloische Zelllinie K562 verwendet und zum Teil mit PMA oder TPCK vorbehandelt. Als Nachweismethode diente die LMPCR, als Vergleichs-DNA die freie Plazenta-DNA AF. Den meisten geschützten Sequenzbereichen, deren Anordnung eine Unterteilung von HSS-2 in zwei Teile ermöglicht, konnten mit der Datenbank Transfac bestimmte Faktoren zugeordnet werden. Einige der identifizierten Proteine spielen in der B-Zellentwicklung eine wichtige Rolle. Eine wahrscheinliche Bindung an die Sequenz des HSS-2-Bereichs ist von E47, Ikaros und NFkB anzunehmen. Alle drei stellen Transkriptionsfaktoren dar, die die B-Zellentwicklung und -differenzierung in verschiedenen Stadien steuern. Als Masterfaktor für die Chromatinöffnung im Igl-Locus kommt vermutlich E47 in Frage, die synergistische Wirkung von HSS-2 wird wahrscheinlich durch NFkB, Ikaros und E47 entscheidend beeinflußt.

Der menschliche Igl-Enhancer besteht aus den drei DNase I-hypersensitiven Regionen HSS-1, -2 und -3, wobei HSS-3 den eigentlichen Enhancer darstellt und HSS-1 und -2 gemeinsam auf HSS-3 synergistisch wirken. Ziel der vorliegenden Arbeit war es, die B-zellspezifische Region HSS-2 näher einzugrenzen und zu charakterisieren. Dazu wurden transiente Transfektionen und In-vivo-Footprinting-Versuche durchgeführt. Die Transfektionsexperimente erfolgten mit den reifen B-Zelllinien MN60 und Daudi. Dazu wurden Luciferasereportergenkonstrukte mit Punktmutationen in den beiden NFkB-Bindungsstellen von HSS-2 oder mit 5’- bzw. 3’-Deletionen in HSS-2 eingesetzt. Die Auswertung der Daten ergab, daß der Transkriptionsfaktor NFkB eine sehr wichtige Rolle in der Regulierung des humanen Igl-Locus spielt. Die Transkriptionskontrolle durch NFkB erfolgt als Bestandteil von Transkriptionskomplexen unter anderem über die Öffnung des Chromatins, womit die DNA auch für andere Faktoren zugänglich wird. Die anschließenden In-vivo-Footprinting-Versuche sollten Aufschluß über die Proteinbedeckung der genomischen DNA von B-Zellen in HSS-2 geben. Für die Untersuchungen wurden die reifen B-Zelllinien Daudi und MN60, die Prä-B-Zelllinie BV173, die T-Zelllinien Jurkat und CCRF-CEM und die myeloische Zelllinie K562 verwendet und zum Teil mit PMA oder TPCK vorbehandelt. Als Nachweismethode diente die LMPCR, als Vergleichs-DNA die freie Plazenta-DNA AF. Den meisten geschützten Sequenzbereichen, deren Anordnung eine Unterteilung von HSS-2 in zwei Teile ermöglicht, konnten mit der Datenbank Transfac bestimmte Faktoren zugeordnet werden. Einige der identifizierten Proteine spielen in der B-Zellentwicklung eine wichtige Rolle. Eine wahrscheinliche Bindung an die Sequenz des HSS-2-Bereichs ist von E47, Ikaros und NFkB anzunehmen. Alle drei stellen Transkriptionsfaktoren dar, die die B-Zellentwicklung und -differenzierung in verschiedenen Stadien steuern. Als Masterfaktor für die Chromatinöffnung im Igl-Locus kommt vermutlich E47 in Frage, die synergistische Wirkung von HSS-2 wird wahrscheinlich durch NFkB, Ikaros und E47 entscheidend beeinflußt.