Podcasts about fusobacterium

We're diving into the oral microbiome and how your mouth could be impacting both egg and sperm quality. Could what's happening in your mouth be impacting your fertility? In this episode, we dive into the surprising connection between your oral microbiome and reproductive health. From silent gum inflammation to the role of mouth breathing, you'll learn how your oral health can influence everything from egg quality and implantation to gut balance and sperm DNA. We're breaking down practical steps—like dental cleanings, gentle oral care, and smart toothpaste swaps—that can make a real difference on your fertility journey. If you're trying to conceive and looking for overlooked but powerful strategies, this one's for you. 

Story at-a-glance Rising incidence of early-onset colorectal cancer is linked to changes in the gut microbiome, with specific bacterial strains producing mutagenic chemicals that contribute to cancer risk Global studies are underway to identify mutational signatures associated with gut bacteria, highlighting the significant role of dysbiosis in colorectal carcinogenesis Understanding the influence of gut bacteria on cancer development could lead to innovative therapeutic strategies, offering new avenues for prevention and treatment Research has identified a subtype of E. coli producing colibactin, a mutagen associated with cancer, suggesting that early exposure increases the risk of developing cancer at a younger age Dysbiosis, characterized by an imbalance in gut microbiota, is linked to colorectal cancer through mechanisms like genotoxicity, inflammation and oxidative stress, with specific bacteria such as Streptococcus bovis and Fusobacterium spp. playing a central role

Episode 183: Colorectal Cancer in Young AdultsFuture Dr. Avila and Dr. Arreaza present evidence-based information about the screening and diagnosis of colorectal cancer and explain the increasing incidence among young adult and the importance to screen early in high risk groups.  Written by Jessica Avila, MS4, American University of the Caribbean School of Medicine. Edits and comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.IntroductionJessica: Although traditionally considered a disease only affecting older adults, colorectal cancer (CRC) has increasingly impacted younger adults (defined as those under 50) at an alarming rate. According to the American Cancer Society, CRC is now the leading cause of cancer-related death in men under 50 and the second leading cause in women under 50 (American Cancer Society, 2024). Arreaza: Why were you motivated to talk about CRC in younger patients?Jessica: Because despite advancements in early detection and treatment, younger patients are often diagnosed at later stages, resulting in poorer outcomes. We will discuss possible causes, risk factors, common symptoms, and why early screening and prevention are important. Arreaza: This will be a good reminder for everyone to screen for colorectal cancer because 1 out of every 5 cases of colorectal cancer occur in adults between the ages of 20 and 54. The Case of Chadwick BosemanJessica: Many people know Chadwick Boseman from his role as T'Challa in Black Panther. His story highlights the worrying trend of increasing CRC in young adults. He was diagnosed with stage III colorectal cancer at age 39. This diagnosis was not widely known until he passed away at 43. His case shows how silent and aggressive young-onset CRC can be. Like many young adults with CRC, his symptoms may have been missed or thought to be less serious issues. His death drew widespread attention to the rising burden of CRC among young adults and emphasized the critical need for increased awareness and early screening efforts.Arreaza: Black Panther became a hero not only in the movie, but also in real life, because he raised awareness of the problem in young AND in Black adults. EpidemiologyJessica: While rates of CRC in older populations have decreased since the 1990s, adults under 50 have seen an increase in CRC rates of nearly 50%. (Siegel et al., 2023). Currently, one in five new CRC diagnoses occurs in individuals younger than 55 (American Cancer Society, 2024).Arreaza: What did you learn about the incidence by ethnic groups? Are there any trends? Jessica: Yes, certain ethnic groups are shown to have higher rates of CRC. Black Americans, Native Americans, and Alaskan Natives have the highest incidence and mortality rates from CRC (American Cancer Society, 2024). Black Americans have a 20% higher incidence and a 40% higher mortality rate from CRC compared to White Americans, primarily due to disparities in access to screening, healthcare resources, and early diagnosis. Hispanic and Asian American populations are also experiencing increasing CRC rates, though to a lesser extent.Arreaza: It is important to highlight that Black Americans have the highest rate of both diagnoses and deaths of all groups in the United States. Who gets colorectal cancer?Risk FactorsJessica: Anyone can get colorectal cancer, but some are at higher risk. In most cases, environmental and lifestyle factors are to blame, but early-onset CRC are linked to hereditary conditions. Arreaza: There is so much to learn about colorectal cancer risk factors. Tell us more.Jessica: The following are key risk factors:Modifiable risk factors:Diet and processed foods: A diet high in processed meats, red meat, refined sugars, and low fiber is strongly associated with an increased risk of CRC. Fiber is essential for gut health, and its deficiency has been linked to increased colorectal cancer risk (Dekker et al., 2023).Obesity and sedentary lifestyle: Obesity and physical inactivity contribute to CRC risk by promoting chronic inflammation, insulin resistance, and metabolic disturbances that promote tumor growth (Stoffel & Murphy, 2023).Gut microbiome imbalance: Disruptions in gut microbiota, especially an overgrowth of Fusobacterium nucleatum, have been noted in CRC pathogenesis, potentially causing tumor development and progression (Brennan & Garrett, 2023).Arreaza: As a recap, processed foods, obesity, sedentarism, and gut microbiome. We also have to mention smoking and high alcohol consumption as major risks factors, but the strongest risk factor is a family history of the disease.Non-modifiable risk factors:Genetic predisposition: Although only 20% of early-onset CRC cases are linked to hereditary syndromes such as Lynch syndrome and familial adenomatous polyposis (FAP), individuals with a first-degree relative with CRC are at a significantly higher risk and should undergo earlier and more frequent screening (Stoffel & Murphy, 2023).Arreaza: Also, there is a difference in incidence per gender assigned at birth, which is also not modifiable. The rate in the US was 33% higher in men (41.5 per 100,000) than in women (31.2 per 100,000) during 2015-2019. So, if you are a man, your risk for CRC is slightly higher. Protective factors, according to the ACS, are physical activity (no specification about how much and how often) and dairy consumption (400g/day). Jessica, let's talk about how colon cancer presents in our younger patients.Clinical Presentation and Challenges in DiagnosisJessica: Young-onset CRC is often diagnosed at advanced stages due to delayed recognition of symptoms. Common symptoms include:Rectal bleeding (often mistaken for hemorrhoids)Young individuals may ignore it, believe they do not have time to address it, or lack insurance to cover a comprehensive evaluation.Unexplained weight lossFatigue or weaknessChanges in bowel habits (persistent diarrhea or constipation)This may also be rationalized by dietary habits.Abdominal pain or bloatingIron deficiency anemia.Arreaza: All those symptoms can also be explained by benign conditions, and colorectal cancer can often be present without clear symptoms in its early stages. Jessica: Yes, in young adults, symptoms may be dismissed by healthcare providers as benign conditions such as irritable bowel syndrome (IBS), hemorrhoids, or dietary intolerance, leading to significant diagnostic delays. Arreaza: We must keep a low threshold for ordering a colonoscopy, especially in patients with the risks we mentioned previously. Jessica: We may also be concerned about the risk/benefit of colonoscopy or diagnostic methods in younger adults, given the traditional low likelihood of CRC. Approximately 58% of young CRC patients are diagnosed at stage III or IV, compared to 43% of older adults (American Gastroenterological Association, 2024). Early recognition and prompt evaluation of persistent symptoms are crucial for improving outcomes. Empowering and informing young adults about concerning symptoms is the first step in better recognition and better outcomes for these individuals.Arreaza: This is when the word “follow up” becomes relevant. I recommend you leave the door open for patients to return if their common symptoms worsen or persist. Let's talk about screening. Screening and PreventionJessica: Due to the trend of CRC being identified in younger populations, the U.S. Preventive Services Task Force (USPSTF) lowered the recommended screening age for CRC from 50 to 45 in 2021 (USPSTF, 2021). Off the record, some Gastroenterologists also foresee the USPSTF lowering the age to 40. Arreaza: That is correct, it seems like everyone agrees now that the age to start screening for average-risk adults is 45. It took a while until everyone came to an agreement, but since 2017, the US Multi-Society Task Force had recommended screening at age 45, the American Cancer Society recommended the same age (45) in 2018, and the USPSTF recommended the same age in 2021. This podcast is a reminder that the age of onset has been decreased from 50 to 45, for average-risk patients, according to major medical associations.Jessica: For individuals with additional risk factors, including a family history of CRC or chronic gastrointestinal symptoms, screening starts at age 40 or 10 years before the diagnosis of colon cancer in a first-degree relative. Dr. Arreaza, who has the lowest and the highest rate of screening for CRC in the US? Arreaza: The best rate is in Massachusetts (70%) and the lowest is California (53%). Let's review how to screen:Jessica: Recommended Screening Methods:Colonoscopy: Considered the gold standard for CRC detection and prevention, colonoscopy allows for identifying and removing precancerous polyps.Fecal Immunochemical Test (FIT): A non-invasive stool test that detects hidden blood, recommended annually.Stool DNA Testing (e.g., Cologuard): This test detects genetic mutations associated with CRC and is recommended every three years.Arreaza: Computed tomographic colonography (CTC) is another option, it is less common because it is not covered by all insurance plans, it examines the whole colon, it is quick, with no complications. Conclusion:Colorectal cancer is rapidly emerging as a serious health threat for young adults. The increase in cases over the past three decades highlights the urgent need for increased awareness, early symptom detection, and proactive screening. While healthcare providers must weigh the risk/benefit of testing for CRC in younger adults, patients must also be equipped with knowledge of concerning signs so that they may also advocate for themselves. Early detection remains the most effective tool in preventing and treating CRC, emphasizing the importance of screening and risk factor modification.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:American Cancer Society. (2024). Colorectal Cancer Statistics, 2024. Retrieved fromhttps://www.cancer.orgAmerican Gastroenterological Association. (2024). Delays in Diagnosis of Young-Onset Colorectal Cancer: A Systemic Issue. Gastroenterology Today.Brennan, C. A., & Garrett, W. S. (2023). Gut Microbiota and Colorectal Cancer: Advances and Future Directions. Gastroenterology.Dekker, E., et al. (2023). Colorectal Cancer in Adolescents and Young Adults: A Growing Concern. The Lancet Gastroenterology & Hepatology.Siegel, R. L., et al. (2023). Colorectal Cancer Statistics, 2023. CA: A Cancer Journal for Clinicians.Stoffel, E. M., & Murphy, C. C. (2023). Genetic and Environmental Risk Factors in Young-Onset Colorectal Cancer. JAMA Oncology.U.S. Preventive Services Task Force. (2021). Colorectal Cancer Screening Guidelines.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

On episode #73 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/16/25 – 1/29/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral AGA clinical practice guideline on the prevention and treatment of hepatitis B virus reactivation (Gastroenterology) Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients (Nature Communications) Insect-specific RNA viruses detection in Field-Caught Aedes aegypti mosquitoes from Argentina using NGS technology (PLoS Neglected Tropical Diseases) Bacterial Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis (NEJM) Impact of antibiotic treatment and predictors for subsequent infections in multidrug-resistant Pseudomonas aeruginosa catheter-associated asymptomatic bacteriuria (American Journal of Infection Control) Identification of the skip phenomenon among patients With Staphylococcus lugdunensis infective endocarditis (OFID) Emergence of infective endocarditis due to Serratia spp. (OFID) Reduction of vancomycin-associated acute kidney injury with montelukast (JID) Fungal The Last of US Season 2 (YouTube) Pulmonary co-infection of Pneumocystis jirovecii and Aspergillus species (OFID) Impact of fluconazoleon outcomes of patients with primary pulmonary coccidioidomycosis (CID) Parasitic Comparative outcomes of Babesiosis in immunocompromised and non-immunocompromised hosts (CID) Miscellaneous Hidradenitis suppurativa (LANCET) A severe case associated with mixed infections of Pasteurella multocida, Bacteroides pyogenes and Fusobacterium necrophorum due to a snow leopard bite (CMI: Clinical Microbiology and Infection) INSIDE-OUT: Introduction of speakers at IDWeek events (OFID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Send us a textIn this conversation, Dr. Debbie Ozment and Kevin discuss the critical link between oral health and cognitive function, particularly in relation to dementia and Alzheimer's disease. They explore how periodontal disease and the oral microbiome can influence systemic inflammation and brain health. The discussion emphasizes the importance of maintaining good oral hygiene and its impact on overall well-being, as well as practical tips for individuals to improve their oral health. The conversation also highlights the role of nutrition and lifestyle choices in supporting oral and cognitive health.You can sign up her "Upstream Gut Health" course discussed today and follow her @drdebbieozment and say hi!!takeawaysThe connection between oral health and brain health is significant.Periodontal disease can compromise the blood-brain barrier.C-reactive protein is a key inflammatory marker to monitor.Maintaining a healthy oral microbiome is crucial for overall health.Simple oral care practices can have profound effects on health.Fusobacterium is linked to colorectal tumors and chemotherapy resistance.Chronic bleeding in the mouth should never be ignored.Nitric oxide plays a vital role in brain health.Oral health is often overlooked in discussions about overall health.Curiosity and continuous learning are essential in health care. Prime Health Associates

Dental Detoxification, the Oral Microbiome, and Our Health with Dr. Sanda Moldovan  In this episode of the RWS Clinician's Corner, Margaret Floyd Barry interviews biological periodontist and nutritionist Dr. Sanda Moldovan.    They discuss:    The connection between oral health and systemic health, including the connection between the oral microbiome and diseases such as heart attacks, cancer and Alzheimer's  Considerations and strategies for testing the oral microbiome The health implications of bleeding gums and bacterial migration Strategies for full mouth detoxification How to mitigate receding gums  How nutrition professionals can support their clients before, during, and after dental procedures such as surgeries and the removal of mercury amalgams  How to find a qualified biological dentist Preventative measures for cavities and the role of pH balance in tooth health The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/  Timestamps:  00:00 Dental school led to serious mercury toxicity issues. 09:50 Fusobacterium linked to gut disease and tumors. 15:02 Focus: Eleven microbes and Il-6 marker testing. 16:13 Three-step dental hygiene reduces periodontal issues. 23:31 Removal of infected tooth improved digestion, palpitations. 26:08 Full mouth health crucial; traditional dentistry overlooked this. 36:08 Recommendations for natural, effective teeth whitening? 39:12 Early diet affects jaw development and airway health. 44:19 Podcast promotes clinical training for health practitioners. 51:04 Teeth can remineralize enamel using calcium hydroxyapatite. 55:10 Fotona laser treats sleep apnea more effectively. 01:00:26 Brush gums with recession; collagen supplements help. 01:06:13 Join, follow, review, share, email topic requests Speaker bio:  Dr. Sanda Moldovan is a distinguished periodontist and nutritionist, renowned for pioneering approaches in natural oral health and wellness. She's the owner of Beverly Hills Health and Dental Wellness, she also founded Orasana, an oral health product line. An advocate for microbiome testing and nutritional therapeutics in dentistry, Dr. Sanda educates professionals and the public alike. A popular speaker and media personality, she hosts "The Holistic Dentistry Show Podcast" and authored: Heal Up!: Seven Ways to Faster Healing and Optimum Health, promoting holistic wellness.   Connect with Dr Sanda:  https://orasana.com/  https://www.drsandamoldovan.com/  https://www.beverlyhillsdentalhealth.com/   https://www.youtube.com/user/AskDrSanda  https://podcasts.apple.com/gb/podcast/holistic-dentistry-show-with-dr-sanda/id1680386392 https://www.instagram.com/drsanda/  https://www.linkedin.com/in/dr-sanda-moldovan-2b601b35/ Keywords:  Sleep apnea diagnosis, CPAP machines, dental appliances, Fotona laser, TMJ treatment, TMD treatment, Botox for TMJ, peptide injections, red light therapy, blue light safety, gum recession, collagen supplementation, gum grafting, functional medicine, mercury toxicity, oral microbiome, cardiovascular disease, neurodegenerative diseases, adverse pregnancy outcomes, systemic health, Actinomyces, Porphyromonas gingivalis, leaky gums, microbiome testing, cone beam CT scan, root canal alternatives, BPA-free fillings, remineralization of teeth, sleep and oral health, holistic dentistry Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Dr. Siobhan McCormack interviews James Kinross, a colorectal surgeon and microbiome researcher. James discusses the potential of robotic surgery and its precision, the link between the microbiome and colorectal cancer, and the importance of preserving gut health. They explore probiotics, evidence-based treatments, and the role of Fusobacterium nucleatum in colorectal cancer. James emphasizes the need for microbial conservation for disease prevention and offers practical advice from his book "Dark Matter" on diet and nutrition for a healthier gut microbiome. This conversation highlights the critical impact of microbiome research on the future of healthcare.This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.Disclaimer:The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

Measles outbreak 2024: Why is measles on the rise? Can bacteria in dental plaque cause colon cancer? CDC measles update, new leading causes of death and colon cancer. Our guest is AMA's Vice President of Science, Medicine and Public Health, Andrea Garcia, JD, MPH. American Medical Association CXO Todd Unger hosts.

KSQD 11-22-2023: Supplements and other advice to combat the side effects of the Shingrix vaccine for shingles; Surge in monkeypox during the summer; The many applications of AI in medicine, from drug interaction help to reading mammograms; Are calcium supplements for osteoporosis affecting my Hashimoto's thyroiditis treatment? Using computational science to improve maternal mortalities during childbirth; New research shows how cadmium, an estrogen mimic, contributes to endometriosis; Fusobacterium levels in the uterus are probably another contributing factor for endometriosis; Kombucha drinks lower blood sugar levels, which is good for diabetes; Irregular sleep patterns affects your microbiome; Irregular sleep patterns affects your microbiome and hence health

Timestamps & Summary Dr. Greg Eckerle (01:24)Do we normally call that intestinal acidosis outside of the agricultural university complex?Dr. Greg PennerI think probably the most common term that's used is hindgut acidosis rather than intestinal acidosis. And it probably makes sense given where we think most of that fermentation activity would occur and where the primary reduction in PH would be localized.Dr. Greg Eckerle (02:02)What can we do with the hindgut intestinal acidosis? And how is that having an impact?Dr. Greg PennerFirst of all, one of the things we need to recognize is rumen acidosis and hindgut acidosis often occur simultaneously. And in fact, we probably should reclassify ruminal acidosis to lumenal, so that it encompasses a broader area of the gastrointestinal tract. You're right, from a challenge or mitigating response, it's not easy to deliver compounds that are going to be released to buffer in the large intestine. So, we're really needing to focus more on strategies that promote ruminal digestion efficiently while minimizing or managing the risk of fermentable materials that reach the large intestine.Dr. Greg Eckerle (05:19)Is there any sort of mitigation practices that we could utilize to help keep that intestinal junction and intestinal villi healthy?Dr. Greg PennerCertainly, our data as well as others have shown that if PH is too low for too long, again, we don't have good thresholds characterized for the hindgut, but we do see a leaky gut, or at least increased permeability of the gut. Our work has been able to show that both outside of the animal using ex vivo conditions and also inside the animal using in vivo markers, we actually see greater permeability responses in post-ruminal regions rather than the ruminal region. […]Dr. Greg Eckerle (08:27)What can we utilize and look at when we see animals undergoing a medicinal acid challenge?Dr. Greg PennerI think it's really hard to differentiate ruminal acidosis and hindgut acidosis. And as I mentioned earlier, they often occur simultaneously. I think in many cases, we've looked at indicators of hindgut acidosis as evidence for ruminal acidosis. And so we've probably been looking at it backward. […]Dr. Greg Eckerle (11:56)Do we see an alteration in more pathogenic bacteria or harmful bacteria to the animal which could lead to increased ailments, transition of other things that enterotoxins, and things like that?Dr. Greg PennerThere was some nice work done by Dr. Kees Plaizier at the University of Manitoba where they did some grain versus alfalfa induction protocols for ruminal acidosis. And fortunately, they have both ruminal microbial changes. And in some of those studies, they also have hindgut microbial changes. And if I recall right, I believe E. Coli abundance, I think they stopped at a genre level, but E. Coli abundance was increased. And so certainly we get concerned about E. Coli from a potential contaminant of meat or meat products and not something we want to increase concentration of, recognizing not all E. Coli will be harmful or truly pathogenic. […]Dr. Greg Eckerle (13:48)When we look at the terminal carcass evaluation of these animals, do we see an increase in liver abscess scores from Fusobacterium that may cross this damaged intestinal?Dr. Greg PennerThat's a great question, and that's the hypothesis we have. But unfortunately, I have not seen any data that confirms whether fusobacterium is crossing the rumen, crossing regions of the intestine, or both. […]Dr. Greg Eckerle (16:15)Are there certain production periods for either both beef and dairy that we need to be paying more attention to with those management practices to help reduce those risks?Dr. Greg PennerLet's start on the dairy side. I think probably the greatest risk factor is early in the transition phase. And the reason I say that is there's a number of changes that have likely occurred during that time. […]In terms of feedlot cattle, I think any factor, again, that leads to a reduction in feed intake, even a transient reduction, probably increases risk for rumen and hindgut acidosis. So, these could be things like respiratory disease, it could be heat stress events, they could be transportation events. […]Dr. Greg Eckerle (21:52)What would be three of the main take-home messages that we have for nutritionists, veterinarians, and producers when we want to help mitigate or strategize systems on farms?Dr. Greg PennerI think the first one is […] that what happens in the rumen influences the more distal parts of the gastrointestinal tract. […]The second one is when we look at the responsiveness of the intestinal regions, they're probably regions that are more prone to leakiness. […]The third one goes back to good standard practices, and I think this will never be eliminated from core tasks or core skills of a nutritionist bunk calling. […]

Ruben Dyrhovden er overlege og mikrobiolog som nylig har disputert. Vi snakker om funnene fra doktorgradsarbeidet hans, og munnhulens bakterier. Kanskje er tannhelse viktigere enn vi tror?Referanser:1. Gianos E, Jackson EA, Tejpal A, Aspry K, O'Keefe J, Aggarwal M, et al. Oral health and atherosclerotic cardiovascular disease: A review. Am J Prev Cardiol. 2021;7:100179.2. Labeau SO, Van de Vyver K, Brusselaers N, Vogelaers D, Blot SI. Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Lancet Infect Dis. 2011;11(11):845-54.3. Fischer, L. A., Demerath, E., Bittner-Eddy, P. & Costalonga, M. Placental colonization with periodontal pathogens: the potential missing link. Am J Obstet Gynecol 221, 383-392 e3 (2019).4. Blanc, V. et al. Oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. Oral Dis 21, 905–912 (2015).5. Han, Y. W. et al. Term Stillbirth Caused by Oral Fusobacterium nucleatum. Obstetrics Gynecol 115, 442–445 (2010).6. Fardini, Y., Chung, P., Dumm, R., Joshi, N. & Han, Y. W. Transmission of Diverse Oral Bacteria to Murine Placenta: Evidence for the Oral Microbiome as a Potential Source of Intrauterine Infection▿ †. Infect Immun 78, 1789–1796 (2010).7. Han, Y. W. et al. Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth. Infect Immun 72, 2272–2279 (2004). Hosted on Acast. See acast.com/privacy for more information.

Download our FREE guide — Top 10 Tips to Live Healthier: zoe.com/freeguideMore than 50 systemic health conditions — including Alzheimer's, diabetes, and heart disease — are associated with oral disease. The link between systemic and oral conditions is always microbial, inflammatory, or both. So, how can we look after our gums to improve our health?In today's episode, Jonathan and Prof. Alp Kantarci pose the question: How does the health of your oral cavity shape your general health?Dr. Alp Kantarci is a professor, scientist, dentist, oral health researcher, periodontist, dental implant surgeon, and senior member of staff at the Forsyth Institute, an independent research institute that focuses on the connections between oral health and overall wellness. Dr. Kantarci is also a faculty member at Harvard University School of Dental Medicine. He has published more than 190 articles in peer-reviewed scientific journals and has presented more than 170 talks and posters at dental and medical congresses.Follow ZOE on Instagram.Timecodes:01:35 - Quickfire questions04:11 - What is oral health?08:35 - How is our oral health connected to the health of the rest of our body?11:01 - Oral microbiome18:48 - Why does bad oral health affect the rest of the body?22:47 - How much does the state of our oral health contribute to dementia?25:48 - The link between oral health and diabetes28:31 - The link between oral health and cardiovascular diseases32:41 - What are the key steps to look after our oral health?35:36 - Alp's view on mouthwash37:51 - Oral health & probiotics42:22 - Impact of food on our oral health45:45 - Does sparkling water affect our oral health?50:04 - Summary52:34 - Goodbyes52:41 - OutroMentioned in today's episode: Dementia and the risk of periodontitis: A population-based cohort study from the Journal of Dental Research.Microglial response to experimental periodontitis in a murine model of Alzheimer's disease from Scientific Reports.Fusobacterium nucleatum dissemination by neutrophils from the Journal of Oral Microbiology.Safety and preliminary efficacy of a novel host-modulatory therapy for reducing gingival inflammation from Frontiers in Immunology.Episode transcripts are available here.Is there a nutrition topic you'd like us to explore? Email us at podcast@joinzoe.com, and we'll do our best to cover it.

In this episode, Dr. Mark Hoffman invites Dr. Ted Lee, an OBGYN specializing in MIGS and professor of OBGYN at University of Pittsburgh Medical Center, about the ambulatory workup of endometriosis patients. --- EARN CME Reflect on how this Podcast applies to your day-to-day and earn free AMA PRA Category 1 CMEs: https://earnc.me/bT7a9b --- SHOW NOTES The episode begins with the physicians discussing the difficulties of diagnosing endometriosis, including: the stigma of pelvic pain/not believing women's pain, recognition that pelvic pain is not normal, the discomfort of physicians asking the appropriate questions for pelvic pain, and the hesitancy towards surgery by physicians and patients all play a role. Many patients have been having pain for years that may have been covered up by OCP use or misdiagnosed as IBS or interstitial cystitis. Ted emphasizes the importance of a thorough history in diagnosing endometriosis. Essential information includes age of onset of symptoms, gravidity and parity, prior C-section (abdominal wall endometriosis) and the “3 D's” of dyspareunia, dyschezia, and most importantly dysmenorrhea. A quality physical exam can also elucidate endometriosis. Ted starts by palpating the anterior vaginal wall, then the levator ani muscles and cervix, and finally the rectovaginal exam. Palpation of the uterosacral ligament and posterior cul-de-sac in endometriosis patients causes a visceral reaction, and advanced disease may also have nodules felt. The majority of patients don't require additional imaging since ultrasound is insensitive for stage 1 and 2 endometriosis. Indications for MRI include endometrioma, nodularities felt on exam, and abdominal wall endometriosis. When it comes to surgery, both doctors emphasize the importance of having other surgeons on your team, including colorectal surgery, general surgery, and urology. Ted dives into some surgical tips and techniques from his years of experience. Finally, the physicians end by discussing the future of endometriosis diagnosis. A Japanese study has recently found fusobacterium in the uterine microbiome in endometriosis patients more often than those without. Also, a French study has taken saliva samples and found signature microRNAs for endometriosis. It will be interesting to see how studies like these change the future of endometriosis diagnosis and if it will bring new challenges, such as overtreatment and overdiagnosis. --- RESOURCES Muraoka, A., Suzuki, M., Hamaguchi, T., Watanabe, S., Iijima, K., Murofushi, Y., Shinjo, K., Osuka, S., Hariyama, Y., Ito, M., Ohno, K., Kiyono, T., Kyo, S., Iwase, A., Kikkawa, F., Kajiyama, H., & Kondo, Y. (2023). Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Science translational medicine, 15(700), eadd1531. https://doi.org/10.1126/scitranslmed.add1531 Bendifallah, S., Suisse, S., Puchar, A., Delbos, L., Poilblanc, M., Descamps, P., Golfier, F., Jornea, L., Bouteiller, D., Touboul, C., Dabi, Y., & Daraï, E. (2022). Salivary MicroRNA Signature for Diagnosis of Endometriosis. Journal of clinical medicine, 11(3), 612. https://doi.org/10.3390/jcm11030612

Karinda has a bone to pick with that recent study on Fusobacterium and Endo! Let the sass begin. The original study The article critiquing the study Connect with Julie: ⁠⁠⁠⁠Email⁠⁠⁠⁠ ⁠⁠⁠⁠Instagram⁠⁠⁠⁠ ⁠⁠⁠Book an appointment with Julie⁠⁠⁠ Connect with Karinda: ⁠⁠⁠⁠Email⁠⁠⁠⁠ ⁠⁠⁠⁠Instagram⁠⁠⁠⁠ ⁠⁠⁠⁠Website⁠⁠⁠⁠ (with resources, cycle shop & more) ⁠⁠⁠Book in with Karinda⁠⁠⁠ DISCLAIMER FOR PUBLIC: The contents of this podcast or any information mentioned is not intended to be a substitute for professional medical advice, diagnosis or treatment. If you're seeking assistance with your health, please contact an accredited healthcare professional. If you'd like personalised support with your health, ⁠⁠⁠you can book a session with Julie or Karinda using the links above. DISCLAIMER FOR HEALTH PRACTITIONERS: The content provided is intended for entertainment and educational purposes. The information discussed in this podcast is not a substitute for professional training. While the authors/hosts make every effort to provide the most up-to-date data and evidence on naturopathic information, this content should not necessarily be considered standard of care and may not reflect individual practices within or outside of Australia. The Nuanced Naturopaths Podcast is a friendly conversation between two friends, that's us! Karinda and Julie. we're passionate about finding the nuance in natural health. As degree-qualified naturopaths, we like to ask the questions that need to be asked - about all aspects of health, healing and well-being. We delight in questioning firmly held beliefs and finding the nuance in all subjects health-related and beyond. Sometimes it can get a little technical but hopefully we explain in a way that is accessible to anyone interested in natural health, whether you're a practitioner or someone who wants to learn more and optimise your wellbeing. It's a chat about poop, periods and everything in between - buckle up for a laugh, a cry and for some things you are yet to consider about your health!

Everybody knows someone battling cancer. Fusobacterium nucleatum is an oral anaerobe that trans-locates to other areas of the body. It negatively impacts gut health in a number of ways including contributing to Irritable Bowel Syndrome. Initially it was found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcomes. It is being widely studied and found to be associated with a growing number of cancers. Recent research is showing that this oral pathogen may induce resistance to several chemotherapy drugs.  The good news is that we can test for it and treat it relatively simply. This is information that can increase your vitality, improve your relationships, and take the stress out of being healthy!References:Fusobacterium nucleatum confers chemoresistance by modulating autophagy in esophageal squamous cell carcinoma (December, 2020)https://www.nature.com/articles/s41416-020-01198-5 Fusobacterium nucleatum:  a new player in regulation of cancer development and therapeutic response (May, 2022)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255244/  Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer (January, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327560/ Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression (June, 2020)https://www.nature.com/articles/s41467-020-16967-2 Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer (February, 2023) https://www.cell.com/trends/microbiology/fulltext/S0966-842X(22)00222-0 The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences?  A systematic review  (April, 2021) https://pubmed.ncbi.nlm.nih.gov/33823861/ Could Periodontal Disease through Periopathogen Fusobacterium nucleatum Be an Aggravating Factor for Gastric Cancer?  (December, 2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761398/ More Than Just a Periodontal Pathogen – the Research Progress on Fusobacterium nucleatum (February, 2022) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851061/ 

In this episode of Defiant Health, I interview Oklahoma dentist, health and wellness coach, and advocate of managing the oral microbiome, Dr. Debbie Ozment. I met Dr. Ozment during one of my two-way weekly video meetups on my DrDavisInfiniteHealth.com where she provided a presentation on the oral microbiome. I was impressed with her tremendous command of this area that drives home the message that oral health and the oral microbiome are major determinants of overall health. She discusses, for instance, how the oral microbe Porphyromonas gingivalis plays a role in Alzheimer's dementia, and Fusobacterium from the gums is proving to be a major cause for colon cancer---all factors you are able to address. I believe you will find Dr. Ozment's interview informative and enlightening.About Dr. OzmentA graduate of Oklahoma University College of Dentistry, she served as adjunct faculty there for seven years. Dr. Ozment completed a Masters' degree in Metabolic and Nutritional Medicine from the University of South Florida Morsani College of Medicine and is a Diplomate with the American Academy of Anti-Aging Medicine. Trained at Mayo Clinic, she is a Nationally Board Certified Health and Wellness Coach.Dr. Ozment's websiteDr. Ozment's TED TalkVitality Made Simple Podcast on Apple PodcastsGUM Picks______________________________________________________________________________________Get your Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, and low-carb snack bars:Use the coupon code "Defiant" for an additional 15% discount. Go to this page on the Paleovalley website, enter the code and the discount will be automatically applied to your order.They are currently offering a 12% discount that continues for life for their Wild Pastures grass-fed, grass-finished beef and pastured chicken and pork! Go herefor more information.______________________________________________________________________________________For more information on Dr. Davis' programs:Books:Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose WeightWheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded editionWheat Belly 10-Day Grain DetoxWheat Belly 30-Minute (Or Less!) CookbookUndoctored: Why Health Care Has Failed You and How You Can Become Smarter Than Your DoctorOnline media:Dr. Davis' Infinite Health Blog: www.DrDavisInfiniteHea

Video: Scientist Carl Sagan testifying to the U.S. Senate in 1985 on the greenhouse effect: (2:00) WEF: The Most Evil Business in the World – Samuel Leeds (10:49) Israel caught hiding BOMBSHELL Pfizer   Frequent nut consumption associated with less inflammation Brigham and Women's Hospital, September 1, 2022 In a study of more than 5,000 people, investigators from Brigham and Women's Hospital have found that greater intake of nuts was associated with lower levels of biomarkers of inflammation, a finding that may help explain the healthbenefits of nuts. The results of the study appear in the American Journal of Clinical Nutrition. “Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,” said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH's Channing Division of Network Medicine. “Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.” Previously Bao and her colleagues observed an association between increased nut consumption and reduced risk of major chronic diseases and even death, but few prospective cohort studies had examined the link between nut intake and inflammation. In the current study, the research team performed a cross-sectional analysis of data from the Nurses' Health Study, which includes more than 120,000 female registered nurses, and from the Health Professionals Follow-Up Study, which includes more than 50,000 male health professionals. The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants. They measured three well-established biomarkers of inflammation: C-reactive protein (CRP), interleukin 6 (IL6) and tumor necrosis factor receptor 2 (TNFR2). After adjusting for age, medical history, lifestyle and other variables, they found that participants who had consumed five or more servings of nuts per week had lower levels of CRP and IL6 than those who never or almost never ate nuts. In addition, people who substituted three servings per week of nuts in place of red meat, processed meat, eggs or refined grains had significantly lower levels of CRP and IL6. Peanuts and tree nuts contain a number of healthful components including magnesium, fiber, L-arginine, antioxidants and unsaturated fatty acids such as α-linolenic acid. Researchers have not yet determined which of these components, or if the combination of all of them, may offer protection against inflammation, but Bao and her colleagues are interested in exploring this further through clinical trials that would regulate and monitor diet. “Much remains unknown about how our diet influences inflammation and, in turn, our risk of disease,” said Bao. “But our study supports an overall healthful role for nuts in the diet and suggests reducing inflammation as a potential mechanism that may help explain the benefits of nuts on cardiometabolic diseases.” Blueberry extract could help fight gum disease and reduce antibiotic use Laval University (Quebec), September 2, 2022 Gum disease is a common condition among adults that occurs when bacteria form biofilms or plaques on teeth, and consequently the gums become inflamed. Some severe cases, called periodontitis, call for antibiotics. But now scientists have discovered that wild blueberry extract could help prevent dental plaque formation. Their report in ACS' Journal of Agricultural and Food Chemistry could lead to a new therapy for periodontitis and a reduced need for antibiotics. Many people have had some degree of gum inflammation, or gingivitis, caused by dental plaque. The gums get red and swollen, and they bleed easily. If left unchecked, the condition can progress to periodontitis. The plaque hardens into tartar, and the infection can spread below the gum line and destroy the tissue supporting the teeth. To treat this condition, dentists scrape off the tartar and sometimes have to resort to conventional antibiotics. But recently, researchers have started looking at natural antibacterial compounds to treat gum disease. Daniel Grenier and colleagues wanted to see if blueberry polyphenols, which work against foodborne pathogens, could also help fight Fusobacterium nucleatum, one of the main species of bacteria associated with periodontitis. In the lab, the researchers tested extracts from the wild lowbush blueberry, Vaccinium angustifolium Ait., against F. nucleatum. The polyphenol-rich extracts successfully inhibited the growth of F. nucleatum, as well as its ability to form biofilms. It also blocked a molecular pathway involved in inflammation, a key part of gum disease. The researchers say they're developing an oral device that could slowly release the extract after deep cleaning to help treat periodontitis. Meat consumption contributing to global obesity University of Adelaide, August 11, 2022 Should we be warning consumers about over-consumption of meat as well as sugar? That's the question being raised by a team of researchers from the University of Adelaide, who say meat in the modern diet offers surplus energy, and is contributing to the prevalence of global obesity. “Our findings are likely to be controversial because they suggest that meat contributes to obesity prevalence worldwide at the same extent as sugar,” says Professor Maciej Henneberg. “In the analysis of obesity prevalence across 170 countries, we have found that sugar availability in a nation explains 50% of obesity variation while meat availability another 50%. After correcting for differences in nations' wealth (Gross Domestic Product), calorie consumption, levels of urbanization and of physical inactivity, which are all major contributors to obesity, sugar availability remained an important factor, contributing independently 13%, while meat contributed another 13% to obesity. “While we believe it's important that the public should be alert to the over-consumption of sugar and some fats in their diets, based on our findings we believe meat protein in the human diet is also making a significant contribution to obesity,” Professor Henneberg says. “There is a dogma that fats and carbohydrates, especially fats, are the major factors contributing to obesity,” Mr You says. “Whether we like it or not, fats and carbohydrates in modern diets are supplying enough energy to meet our daily needs. Because meat protein is digested later than fats and carbohydrates, this makes the energy we receive from protein a surplus, which is then converted and stored as fat in the human body.” “Nevertheless, it is important that we show the contribution meat protein is making to obesity so that we can better understand what is happening. In the modern world in which we live, in order to curb obesity it may make sense for dietary guidelines to advise eating less meat, as well as eating less sugar,” he says. Study suggests possible link between artificial sweeteners and heart disease French National Institute for Health and Medical Research, September 7, 2022 A large study of French adults published by The BMJ today suggests a potential direct association between higher artificial sweetener consumption and increased cardiovascular disease risk, including heart attack and stroke. The findings indicate that these food additives, consumed daily by millions of people and present in thousands of foods and drinks, should not be considered a healthy and safe alternative to sugar, in line with the current position of several health agencies. Artificial sweeteners are widely used as no- or low-calorie alternatives to sugar. They represent a $7.2 billion (£5900m; €7000m) global market and are found in thousands of products worldwide, particularly ultra-processed foods such as artificially sweetened drinks, some snacks, and low calorie ready meals. Several studies have linked consumption of artificial sweeteners or artificially sweetened beverages (ASB) to weight gain, high blood pressure, and inflammation. To investigate this further, a team of researchers at the French National Institute for Health and Medical Research (Inserm) and colleagues drew on data for 103,388 participants (average age 42 years; 80% female) of the web-based NutriNet-Santé study, launched in France in 2009 to investigate relations between nutrition and health. Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24-hour dietary records and a range of potentially influential health, lifestyle, and sociodemographic factors were taken into account. A total of 37% of participants consumed artificial sweeteners, with an average intake of 42.46 mg/day, which corresponds to approximately one individual packet of table top sweetener or 100 mL of diet soda. The researchers found that total artificial sweetener intake was associated with an increased risk of cardiovascular disease (absolute rate 346 per 100,000 person years in higher consumers and 314 per 100,000 person years in non-consumers). Artificial sweeteners were more particularly associated with cerebrovascular disease risk (absolute rates 195 and 150 per 100,000 person-years in higher and non-consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (186 and 151 per 100,000 person-years in higher and non-consumers, respectively), while acesulfame potassium and sucralose were associated with increased coronary heart disease risk (acesulfame potassium: 167 and 164 per 100,000 person-years; sucralose: 271 and 161 per 100,000 person-years in higher and non-consumers, respectively). Your soap and toothpaste could be messing with your microbiome University of Chicago, September 2, 2022 Antimicrobial chemicals found in common household products could be wreaking havoc with people's guts, according to a research paper out this week in the journal Science. Triclosan is an antibacterial compound used in soaps, detergent and toothpaste, as well as toys and plastics. It was originally only used in hospitals, but it found its way into homes as Americans became more germ-phobic. (However, recent studies have found it no more effective at killing bacteria than plain soap. ) Now, there are growing concerns about the possible negative effects of the chemical on human health and the environment. According to the US Food and Drug Administration (FDA), animal studies have shown that the chemical can act as a hormone disruptor. A 2008 study found traces of triclosan in the urine of 75% of the participants – some as young as six. The chemical has also been found in more than half of freshwater streams in the US. Disturbing the human microbiome has been “linked to a wide array of diseases and metabolic disorders, including obesity, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and behavioral and metabolic disorders,” wrote the paper's authors, Alyson L Yee and Jack A Gilbert. Yee and Gilbert also suggested that exposure to triclosan could be even more detrimental to the health of developing fetuses and newborns than to adults. A 2014 New York University study found that gut disruptions in early infancy could have lasting negative effects on immune and brain development. Triclosan could also be contributing to antibiotic resistance, which scientists believe is caused by the overuse of antimicrobials in humans and animals. There are partial bans of the chemical in the European Union and in Minnesota, and the FDA says it will continue reviewing the chemical for its safety. Exposure to phthalates could be linked to pregnancy loss Peking University, September 2, 2022 A new study of more than 300 women suggests that exposure to certain phthalates — substances commonly used in food packaging, personal-care and other everyday products — could be associated with miscarriage, mostly between 5 and 13 weeks of pregnancy. The research, appearing in the ACS journal Environmental Science & Technology, is the first epidemiological study on non-work-related exposure to phthalates to provide evidence for the possible link among a general population. Out of concern over the potential health effects of phthalates, the U.S. has banned six of these substances from use in certain products made for young children. But many are still included as ingredients in paints, medical tubes, vinyl flooring, soaps, shampoos and other items. Research on phthalates has shown that long-term exposure to low levels of some of these compounds harms lab animals' health and can increase their risk for pregnancy loss. Additionally, at least one study found that female factory workers exposed to high levels of phthalates through their work were at a higher risk for miscarriage. But there is little epidemiological evidence of phthalates' effects on pregnancy among women with non-occupational exposure. Jianying Hu, Huan Shen and colleagues wanted to find out if there might be a link. The researchers tested urine samples from 132 women who had miscarriages and 172 healthy pregnant women in China. They found pregnancy loss was associated with higher levels of urinary phthalate metabolites from diethyl phthalate (DEP), di-isobutyl phthalate (DiBP) and di-n-butyl phthalate (DnBP). Although this doesn't prove that phthalates cause pregnancy loss, the study suggests an association exists that the researchers say should be studied further.

Welcome to PICU Doc On Call, A Podcast Dedicated to Current and Aspiring Intensivists. I'm Pradip Kamat coming to you from Children's Healthcare of Atlanta/Emory University School of Medicine and I'm Rahul Damania from Cleveland Clinic Children's Hospital and we are two Pediatric ICU physicians passionate about all things MED-ED in the PICU. PICU Doc on Call focuses on interesting PICU cases & management in the acute care pediatric setting so let's get into our episode: Welcome to our Episode an 18 -year old with sore throat, and unilateral L-sided neck pain for ~2 weeks. Here's the case presented by Rahul: An 18-year-old female presents to the ED with cough, fever, fatigue, sore throat, and unilateral L-sided neck pain for ~2 weeks. The patient also has been having non-specific chest pain, weight loss, and decreased appetite for ~ 1 month. Patient has no recent travel h/o, no h/o of vaping or illicit drug use, and there were no sick contacts at home. Vitals revealed an HR 105, BP 116/66, Temp 38.3, and respiratory rate 35, She was 65 Kg and SPO2 on 2L NC was 100%. Physical exam was negative except (L) neck tender to palpation. There was no goiter, lymphadenopathy or hepatosplenomegaly. An initial chest x-ray was significant for possible multi-lobar pneumonia versus metastases. A Chest CT revealed multifocal septic emboli in the lungs. Echo did not show any gross vegetation. She has no rash or any trauma to the neck or difficulty swallowing, no oral ulcers, joint pain, or diarrhea. She had no recent dental work or drinking of unpasteurized milk or eating raw fish or meat. She was admitted to the PICU as she had hypotension requiring fluid boluses, and lab works significant for hyponatremia, rhabdomyolysis, worsening AKI, elevated ferritin, and elevated D-dimer. Her serum uric acid was 9.9, LDH = 230 (normal) ,ESR 78 (normal = 20 or less). Her serum lactate and serum troponin and BNP were all normal. Pertinently, US neck revealed an occlusive thrombus in the (L) IJ vein (done so as to avoid contrast in face of AKI), and blood cultures sent. To summarize key elements from this case, this 18-year-old female presents with fever +cough+sore throat Fatigue + Weight loss (L) neck pain Hypotension with abnormal labs including a concerning WBC with (L) shift, anemia, AKI, elevated uric acid, and ESR Chest CT with possible pulmonary emboli US showing occlusion. All of which brings up a concern for possible malignancy or pulmonary emboli from a septic focus in the neck and a possible diagnosis of Lemierre syndrome This episode will be organized… Definition Diagnosis (physical, laboratory) Management Rahul: What is the definition of Lemierre's syndrome? Lemierre's syndrome, also known as post-anginal septicemia or necrobacillosis, is characterized by bacteremia, internal jugular vein thrombophlebitis, and metastatic septic emboli secondary to acute pharyngeal infections. All of which are seen in our above case presentation. Previously called as the forgotten disease as its incidence was decreasing due to the increasing use of antibiotics especially penicillin for URI. However, recently there is an increase in Lemierre's disease cases with decreased use of antibiotics due to antibiotic stewardship. The recent increase in Lemierre disease due to decreased antibiotic use has not been proven and remain controversial. Rahul what are some of the causative organisms of Lemierre syndrome? The most common causative agent of Lemierre's syndrome is Fusobacterium necrophorum, followed by Fusobacterium nucleatum and anaerobic bacteria such as streptococci, staphylococci, and Klebsiella pneumoniae. Rahul: Can you tell our listeners about the pathophysiology of Lemierre's syndrome? Lemierre syndrome can occur in health adults (more common in males in the age group of 14-24 years). Risk factors include immunocompromised patients, organisms, and environmental conditions. Lipopolysaccharides in F. necrophorum have endotoxic...

Could probiotics restore microbiome imbalance linked to autoimmune disorder? UCLA and Oslo University Probiotics might help restore gut bacterial imbalance in patients with systemic sclerosis, says a new study looking at gastrointestinal bacterial compositions in two geographically-distinct populations suffering from the autoimmune disorder. Systemic sclerosis is an autoimmune disease which impacts the body's connective tissue. It is an uncommon condition that results in hard, thickened areas of skin and sometimes problems with internal organs and blood vessels.The study ran across the US and Norway and found that Norwegians and Americans with systemic sclerosis had higher levels of bacteria which can cause inflammation and lower levels of bacteria which are said to protect against inflammation compared to those not suffering from systemic sclerosis.The study found that those with systemic sclerosis had significantly lower levels of gut bacteria which is thought to protect against inflammation, such as Bacteroides.They were also found to have higher amounts of bacteria which promote inflammation, such as Fusobacterium, in comparison to those without systemic sclerosis.The study suggests that probiotics may aid restoring gut bacterial balance in those suffering from systemic sclerosis.   Caraway extract shows slimming potential for women University of Malaya (Malaysia),  An aqueous extract of caraway seeds may suppress appetite and help slim waistlines and thighs in physically active women, says a new study. Data published in Phytotherapy Research indicated that 90 days of supplementation with the caraway (Carum carvi L.) extract led to significant reductions in waist circumference of 6.2 cm and thigh circumference of 5.4 cm, compared to baseline levels. No significant waist reductions were recorded in the placebo group. “This study showed that the consumption of 30 mL/day CAE [caraway aqueous extract] may result in reasonable anti-obesity effects,” wrote the researchers. “Most likely, this occurs through a combination of four major bioactivities, including anti-microbial, anti-oxidant, and anti-inflammatory properties, together with the appetite-suppressing activity. Scientists from the University of Malaya (Malaysia), Shahid Beheshti University of Medical Sciences (Iran), and Natural Products Inc (USA) recruited 70 aerobically trained, overweight, and obese women to participate in their triple-blind, placebo-controlled, clinical study. The women – who were instructed to not change their diet or physical activity – were randomly assigned to receive either the caraway extract or placebo for 90 days. Results showed that women in the caraway group had significant reductions in both appetite levels and carbohydrate intake compared with the placebo group. Commenting on the potential bioactives compounds responsible for the effects, the researchers note that caraway seed extracts contain volatile compounds such as limonene, gamma-terpinene, trans-carveol, carvone, thymol, and carvacrol. Friends Provide Better Pain Relief Than Morphine, Oxford University Study Reveals Oxford University Recent studies have explored the science behind friendships and discovered that there are actually measurable differences between people who have strong, healthy social networks and those who don't. In particular, people with strong friend connections were found to experience significantly better states of physical and mental health. “People with social support have fewer cardiovascular problems and immune problems, and lower levels of cortisol — a stress hormone,” says Tasha R. Howe, PhD, associate professor of psychology at Humboldt State University. Adding to the growing research on the benefits of friendship, a recent study conducted by researchers at Oxford University established that people with more friends have higher pain tolerance.  The study was designed to use pain tolerance to test the brain's endorphin activity. The researchers theorised that people with larger social networks would, as a result, have higher pain tolerance. The findings of the study supported their theory in that it showed that indeed, strong social connections were correlated with higher pain tolerance. As mentioned in the final statement it is not just the size of our social network that is important to our wellbeing, but the quality of the friendships that matters as well. With the advent of the internet modern society is changing quickly, and our interactions are increasingly occurring online. Even though the internet can be a great way to connect with likeminded people, online friends just aren't the same as those we can actually sit with and look directly in the eye when we communicate–and a digital hug is just nowhere near as good as a real one!  Videos: 1. Pfizer CEO Albert Bourla explains Pfizer's new tech to Davos crowd (0:25) 2. You'll Never See This on Tell Lie Vision (2:19) 3. Jimmy Dore-  TV War “Experts” Revealed As Paid Shills For Weapons Manufacturers  (only first 6:00) 5. SHOCKING! Assad Spills Truth About Ukraine Conflict and NATO by Richard Medhurst (11:50)

What in the world does your Mother-in-Law have in common with a potentially dangerous gut bacterium?  Fusobacterium nucleatum is a hot topic in research literature. This is information that can increase your vitality and take the stress out of being healthy!

Wet weather this spring and summer has certainly created ideal conditions for foot problems in sheep. Nearly continuous exposure to moisture softens the hoof's horny tissues and makes it more vulnerable to irritation, injury, and infection. Those flocks that are affected by classic virulent foot rot (sometimes called contagious foot rot) have likely seen a surge in the number and severity of cases if they have not been attempting to control or eradicate this potentially devastating disease.Those flock owners who have experienced milder forms of lameness in their flocks may assume that they don't have foot rot but have a milder condition called “foot scald” or “scald.” Actually there are really two recognized conditions that are sometimes referred to as “scald.” At first the difference may seem academic, but for some producers, it may be more than that.Virulent, or contagious, foot rot is caused by a synergistic infection with two organisms, Dichelobacter nodosus (formerly Bacteroides nodosus) and Fusobacterium necrophorum. This last organism is in virtually all sheep environments and sets the stage for infection with the organism necessary for foot rot to occur — Dichelobacter nodosus. This organism produces a powerful proteolytic enzyme that dissolves hoof horn and leads to the undermining of the sole, the severe lameness, the foul smell, and the abnormal hoof growth seen with classic virulent foot rot. About 20 different strains of D. nodosus are believed to occur in the US.True foot rot does not occur in the absence of D. nodosus. However, a less persistent and generally milder condition in which only inflammation between the toes and a slight under-running of the hoof horn occurs in some flocks. Both D. nodosus and F. necrophorum can be isolated from these cases, but the strains of D. nodosus isolated seem have a reduced virulence or ability to produce disease. This condition is technically referred to as benign foot rot but has also been called foot “scald.” It is believed that the strains of D. nodosus that are involved are weak enzyme producers and are less able to produce the severe damage seen with virulent foot rot.Another infectious and inflammatory condition which involves only the skin between the claws without significant undermining of the horny tissue has been termed ovine interdigital dermatitis (OID), and it has also been called “scald.” The bacteria associated with this condition are F. necrophorum and Actinomyces pyogenes; both of which tend to be common in typical sheep environments. D. nodosus is not involved. The disease usually only occurs when the weather and other conditions on the farm damage the skin and allow these bacteria to create skin infections.  Because the term “scald” has been applied to both OID and benign foot rot, the use of that term can be misleading.  Both conditions usually cause only mild or temporary lameness that may be obvious only in wet periods of the year. From a practical standpoint, the two conditions are difficult to distinguish from one another, and laboratory capability to isolate and serotype D. nodusus is generally not readily available. Foot baths and soaks with 10% zinc sulfate usually result in improved healing of either condition. Foot “scald” often disappears when the environmental conditions become dry.So if the two conditions called “scald” are not easy to differentiate and they both tend to clear up with foot bathing or dry weather, why even bother to make the distinction? There are two reasons that may be important to some producers. The first is that all the strains of D. nodosus, whether they produce virulent or benign foot rot, are maintained in the flock by sheep that harbor the infection in cracks and crevices on their feet — carrier animals. That means that most likely, unless an attempt at eradication is made, benign foot rot will be back again as soon as the weather conditions favorable for foot softening&

TWiM reviews aspirin modulation of Fusobacterium nucleatum, a microbe that has been associated with colorectal cancer, and Elio tells us ‘What are vaccines’, a talk he recently gave to members of his community. Links for this episode: Elio’s What are Vaccines? (pdf) Jenner Museum Aspirin modulation of Fusobacterium (mBio) Fecal transplant for C. difficile (NEJM) Fecal microbiota transplantation (NEJM) Fecal microbiota transplant for dysbiosis (NEJM) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

O Fusobacterium semella un pasaxeiro inofensivo do noso microbioma que temos na boca, ou na vaxina. Pero malia a súa cara bonita, esta bacteria anda con moi malas compañas e iso agora sabemos que non é casualidade. Circo de Bacterias con Esteban Fernández Moreira.

O Fusobacterium semella un pasaxeiro inofensivo do noso microbioma que temos na boca, ou na vaxina. Pero malia a súa cara bonita, esta bacteria anda con moi malas compañas e iso agora sabemos que non é casualidade. Circo de Bacterias con Esteban Fernández Moreira.

FDA 批准新药用于治疗便秘型肠易激综合征Lancet 溃疡性结肠炎患者患结直肠癌的风险Nature Medicine 循环肿瘤DNA测序在晚期胃肠道肿瘤中的临床应用替那帕诺（tenapanor）替那帕诺（Tenapanor）是一种不被肠道吸收的、胃肠道钠/氢交换蛋白异构体3的小分子抑制剂。2019年9月，被FDA批准用于治疗成人便秘型肠易激综合征。《T3MPO-1研究：替那帕诺治疗便秘型肠易激综合征的3期临床研究》American Journal of Gastroenterology，2020年2月 (1)这项三期试验评估了替那帕诺 50 mg bid治疗便秘型肠易激综合征的有效性和安全性。研究纳入606例患者，随机分为替那帕诺组或安慰剂组，为期12周，然后进入4周的停药期。患者平均年龄45岁，81.4%女性。替那帕诺治疗组有27%的患者6周以上、每周腹痛减轻30%且至少一次自主排便；安慰剂组仅18.7%（P = 0.020）。替那帕诺对腹部症状和整体症状也有改善（P < 0.05）。腹泻是最常见的不良事件，在12周的治疗期间，分别有6.5%和0.7%的接受替那帕诺和安慰剂的患者停药。结论：替那帕诺50 mg bid可改善了便秘型肠易激综合征的症状，总体耐受性良好，为便秘型肠易激综合征患者提供了一个潜在的新的治疗选择。炎症性肠病炎症性肠病（inflammatory bowel disease，IBD）由两大类疾病组成，溃疡性结肠炎（ulcerative colitis，UC）和克罗恩病（Crohn's disease，CD）。溃疡性结肠炎特点是局限于结肠黏膜层的炎症复发与缓解交替出现，几乎均会累及直肠，并且通常向近端以连续性蔓延的方式累及结肠的其他部分。克罗恩病的特征是透壁性炎症和跳跃性病灶，导致管腔纤维化和狭窄，常见梗阻、窦道、穿孔。除了肠道症状外，可伴有口腔溃疡、关节炎、葡萄膜炎等。IBD的发病机制尚不清楚，主要危险因素包括：发病年龄有15-40岁和50-80岁两个高峰期；犹太人中更常见；家族史；吸烟；富含精加工、油炸、含糖食物西方膳食模式；感染和抗生素使用等。《3个前瞻性队列研究：饮食炎症的潜在和克罗恩病和溃疡性结肠炎的风险》Gastroenterology，2020年9月 (2)研究分析了来自3个大型的、前瞻性、队列性研究的数据，目的是评价饮食炎症能对克罗恩病和溃疡性结肠炎的患病风险的影响。研究收集了护士健康研究、护士健康研究II和卫生专业人员随访研究中的、166,903名女性和41,931名男性的数据。累计随访4,949,938人年，记录了328例克罗恩病和428例溃疡性结肠炎。诊断IBD的中位年龄为55岁。与累积平均、实证饮食炎症模式（Empirical dietary inflammatory pattern，EDIP）得分最低的四分位参与者相比，最高四分位的参与者患克罗恩病的风险高出51%（风险比1.51，P=0.01）。与实证饮食炎症模式评分持续较低的参与者相比，那些从低炎症潜能饮食、转变为促炎饮食，或持续摄入促炎饮食的参与者的、患克罗恩病的风险更大（风险比 2.05和 1.77）。相反，饮食中的炎症潜能与发生溃疡性结肠炎的风险无关。结论：在对3个大型前瞻性队列的分析中，我们发现高炎症潜能的饮食模式与克罗恩病风险增加有关，但与溃疡性结肠炎无关。《2项前瞻性队列研究：坚持地中海饮食可降低晚发克罗恩病的风险》Gut，2020年9月 (3)这2项前瞻性队列研究，共有83 147名参与者、年龄范围45-79岁，随访17年。随访中记录了克罗恩病164例，溃疡性结肠炎395例。改良地中海饮食依从性评分越高，克罗恩病风险越低（P=0.03），与溃疡性结肠炎无关。这种相关性不受年龄、性别、教育水平、体重指数或吸烟程度的影响。在研究中，地中海饮食依从性差的参与者患克罗恩率的比例为27%，这意味着患晚发性克罗恩病的人口归因风险为12%。结论：在2项前瞻性研究中，坚持地中海饮食可以显著降低晚发克罗恩病的风险。《前瞻性病例对照研究：抗生素的使用和IBD的发展》Lancet Gastroenterology & Hepatology，2020年11月 (4)早期使用抗生素与儿童IBD有关，但成年人IBD的关系尚不确定调查抗生素治疗和IBD之间的关系，在一个大规模的，以人群为基础的研究。在这项前瞻性病例对照研究中，纳入了新确诊了23 982例IBD患者（15 951例溃疡性结肠炎，7898例克罗恩病，133例未分类IBD），117 827例对照组和28 732同胞兄妹。在调整了几种危险因素后，使用抗生素的患者IBD发病的风险比为1·88，溃疡性肠炎的风险比1·74，克罗恩病的风险比2·27，均有统计学意义。接受1次抗生素、2次抗生素、≥3次抗生素的IBD风险比分别为1.11、1.38和1·55，显著高于没有使用抗生素的患者。使用≥3种抗生素的人群中，溃疡性结肠炎发病风险比1·47，克罗恩病发病风险比1·64，均显著增加。当同胞兄妹作为参照组时，观察到类似的结果，但相关性减弱，≥3种抗生素时风险比1·35。结论：抗生素治疗累积暴露，可能与新发IBD风险增加相关。《基础研究：使用生物标志物识别5年内将发展为克罗恩病的患者》Gastroenterology，2020年7月 (5)研究的目的是鉴定克罗恩病和溃疡性结肠炎的，诊断前即可检测、量化的血清生物标记物。研究人员提取了200例克罗恩病，199例溃疡性结肠炎以及200名健康个体的血清样本，测量了针对微生物的抗体（抗酿酒酵母IgA或IgG、抗大肠杆菌外膜孔蛋白C、抗CBir1、抗鞭毛蛋白2、抗鞭毛蛋白X和核周抗中性粒细胞细胞质抗体）以及1129个蛋白的水平。然后使用功能主成分分析来推导每个标记的时变轨迹，将其用于多变量模型来预测疾病状态，克罗恩病患者血清中上调的生物学途径是根据诊断前不同时期蛋白丰度的变化确定的。研究人员鉴定了一组51个蛋白生物标记物，预测5年内诊断克罗恩病的曲线下面积为0.76，预测1年内诊断克罗恩病的曲线下面积为0.87。结论：我们鉴定了一组血清抗体和蛋白，它们可以预测患者在5年内获得高准确度的克罗恩病诊断。相比之下，我们没有确定与溃疡性结肠炎的未来诊断相关的生物标记物。《基于人群的队列研究：溃疡性结肠炎中的结直肠癌》Lancet，2020年1月(6)研究的目的是比较溃疡性结肠炎患者结直肠癌的发生率和死亡率的风险。这个以人群为基础的队列研究中，纳入48年间、96 447例溃疡性结肠炎患者。溃疡性结肠炎中发生结直肠癌的几率是1·29/1000人年，风险比 1·66。溃疡性结肠炎中死于结直肠癌的几率是0·55/1000人年，风险比 1·59。虽然溃疡性结肠炎患者发现结直肠癌时的分期较早（p

FDA 批准新药用于治疗便秘型肠易激综合征Lancet 溃疡性结肠炎患者患结直肠癌的风险Nature Medicine 循环肿瘤DNA测序在晚期胃肠道肿瘤中的临床应用替那帕诺（tenapanor）替那帕诺（Tenapanor）是一种不被肠道吸收的、胃肠道钠/氢交换蛋白异构体3的小分子抑制剂。2019年9月，被FDA批准用于治疗成人便秘型肠易激综合征。《T3MPO-1研究：替那帕诺治疗便秘型肠易激综合征的3期临床研究》American Journal of Gastroenterology，2020年2月 (1)这项三期试验评估了替那帕诺 50 mg bid治疗便秘型肠易激综合征的有效性和安全性。研究纳入606例患者，随机分为替那帕诺组或安慰剂组，为期12周，然后进入4周的停药期。患者平均年龄45岁，81.4%女性。替那帕诺治疗组有27%的患者6周以上、每周腹痛减轻30%且至少一次自主排便；安慰剂组仅18.7%（P = 0.020）。替那帕诺对腹部症状和整体症状也有改善（P < 0.05）。腹泻是最常见的不良事件，在12周的治疗期间，分别有6.5%和0.7%的接受替那帕诺和安慰剂的患者停药。结论：替那帕诺50 mg bid可改善了便秘型肠易激综合征的症状，总体耐受性良好，为便秘型肠易激综合征患者提供了一个潜在的新的治疗选择。炎症性肠病炎症性肠病（inflammatory bowel disease，IBD）由两大类疾病组成，溃疡性结肠炎（ulcerative colitis，UC）和克罗恩病（Crohn's disease，CD）。溃疡性结肠炎特点是局限于结肠黏膜层的炎症复发与缓解交替出现，几乎均会累及直肠，并且通常向近端以连续性蔓延的方式累及结肠的其他部分。克罗恩病的特征是透壁性炎症和跳跃性病灶，导致管腔纤维化和狭窄，常见梗阻、窦道、穿孔。除了肠道症状外，可伴有口腔溃疡、关节炎、葡萄膜炎等。IBD的发病机制尚不清楚，主要危险因素包括：发病年龄有15-40岁和50-80岁两个高峰期；犹太人中更常见；家族史；吸烟；富含精加工、油炸、含糖食物西方膳食模式；感染和抗生素使用等。《3个前瞻性队列研究：饮食炎症的潜在和克罗恩病和溃疡性结肠炎的风险》Gastroenterology，2020年9月 (2)研究分析了来自3个大型的、前瞻性、队列性研究的数据，目的是评价饮食炎症能对克罗恩病和溃疡性结肠炎的患病风险的影响。研究收集了护士健康研究、护士健康研究II和卫生专业人员随访研究中的、166,903名女性和41,931名男性的数据。累计随访4,949,938人年，记录了328例克罗恩病和428例溃疡性结肠炎。诊断IBD的中位年龄为55岁。与累积平均、实证饮食炎症模式（Empirical dietary inflammatory pattern，EDIP）得分最低的四分位参与者相比，最高四分位的参与者患克罗恩病的风险高出51%（风险比1.51，P=0.01）。与实证饮食炎症模式评分持续较低的参与者相比，那些从低炎症潜能饮食、转变为促炎饮食，或持续摄入促炎饮食的参与者的、患克罗恩病的风险更大（风险比 2.05和 1.77）。相反，饮食中的炎症潜能与发生溃疡性结肠炎的风险无关。结论：在对3个大型前瞻性队列的分析中，我们发现高炎症潜能的饮食模式与克罗恩病风险增加有关，但与溃疡性结肠炎无关。《2项前瞻性队列研究：坚持地中海饮食可降低晚发克罗恩病的风险》Gut，2020年9月 (3)这2项前瞻性队列研究，共有83 147名参与者、年龄范围45-79岁，随访17年。随访中记录了克罗恩病164例，溃疡性结肠炎395例。改良地中海饮食依从性评分越高，克罗恩病风险越低（P=0.03），与溃疡性结肠炎无关。这种相关性不受年龄、性别、教育水平、体重指数或吸烟程度的影响。在研究中，地中海饮食依从性差的参与者患克罗恩率的比例为27%，这意味着患晚发性克罗恩病的人口归因风险为12%。结论：在2项前瞻性研究中，坚持地中海饮食可以显著降低晚发克罗恩病的风险。《前瞻性病例对照研究：抗生素的使用和IBD的发展》Lancet Gastroenterology & Hepatology，2020年11月 (4)早期使用抗生素与儿童IBD有关，但成年人IBD的关系尚不确定调查抗生素治疗和IBD之间的关系，在一个大规模的，以人群为基础的研究。在这项前瞻性病例对照研究中，纳入了新确诊了23 982例IBD患者（15 951例溃疡性结肠炎，7898例克罗恩病，133例未分类IBD），117 827例对照组和28 732同胞兄妹。在调整了几种危险因素后，使用抗生素的患者IBD发病的风险比为1·88，溃疡性肠炎的风险比1·74，克罗恩病的风险比2·27，均有统计学意义。接受1次抗生素、2次抗生素、≥3次抗生素的IBD风险比分别为1.11、1.38和1·55，显著高于没有使用抗生素的患者。使用≥3种抗生素的人群中，溃疡性结肠炎发病风险比1·47，克罗恩病发病风险比1·64，均显著增加。当同胞兄妹作为参照组时，观察到类似的结果，但相关性减弱，≥3种抗生素时风险比1·35。结论：抗生素治疗累积暴露，可能与新发IBD风险增加相关。《基础研究：使用生物标志物识别5年内将发展为克罗恩病的患者》Gastroenterology，2020年7月 (5)研究的目的是鉴定克罗恩病和溃疡性结肠炎的，诊断前即可检测、量化的血清生物标记物。研究人员提取了200例克罗恩病，199例溃疡性结肠炎以及200名健康个体的血清样本，测量了针对微生物的抗体（抗酿酒酵母IgA或IgG、抗大肠杆菌外膜孔蛋白C、抗CBir1、抗鞭毛蛋白2、抗鞭毛蛋白X和核周抗中性粒细胞细胞质抗体）以及1129个蛋白的水平。然后使用功能主成分分析来推导每个标记的时变轨迹，将其用于多变量模型来预测疾病状态，克罗恩病患者血清中上调的生物学途径是根据诊断前不同时期蛋白丰度的变化确定的。研究人员鉴定了一组51个蛋白生物标记物，预测5年内诊断克罗恩病的曲线下面积为0.76，预测1年内诊断克罗恩病的曲线下面积为0.87。结论：我们鉴定了一组血清抗体和蛋白，它们可以预测患者在5年内获得高准确度的克罗恩病诊断。相比之下，我们没有确定与溃疡性结肠炎的未来诊断相关的生物标记物。《基于人群的队列研究：溃疡性结肠炎中的结直肠癌》Lancet，2020年1月(6)研究的目的是比较溃疡性结肠炎患者结直肠癌的发生率和死亡率的风险。这个以人群为基础的队列研究中，纳入48年间、96 447例溃疡性结肠炎患者。溃疡性结肠炎中发生结直肠癌的几率是1·29/1000人年，风险比 1·66。溃疡性结肠炎中死于结直肠癌的几率是0·55/1000人年，风险比 1·59。虽然溃疡性结肠炎患者发现结直肠癌时的分期较早（p

On this week's episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH takes us through orange complex bacteria!   Quotes:    “Fusobacterium nucleatum is the predominant bacteria present in preterm births in humans with periodontal disease and Fusobacterium nucleatum has also demonstrated association with colon cancer and induces tumor growth in colon tissue.”   “These orange complex bacteria, although they are moderate risk bacteria, set the stage, so to speak, for our red complex bacteria.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/  Citations:   Mohanty, R., Asopa, S.J., Joseph, M.D., et al. Red complex: Polymicrobial conglomerate in oral flora: A review. J Family Med Prim Care. 2019; 8(11): 3480-3486. Published 2019 Nov 15. doi:10.4103/jfmpc.jfmpc_759_19   Mohanty, R., Asopa, S. J., Joseph, M. D., Singh, B., Rajguru, J. P., Saidath, K., & Sharma, U. (2019). Red complex: Polymicrobial conglomerate in oral flora: A review. Journal of family medicine and primary care, 8(11), 3480–3486. https://doi.org/10.4103/jfmpc.jfmpc_759_19

On this week’s episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH takes us through orange complex bacteria!   Quotes:    “Fusobacterium nucleatum is the predominant bacteria present in preterm births in humans with periodontal disease and Fusobacterium nucleatum has also demonstrated association with colon cancer and induces tumor growth in colon tissue.”   “These orange complex bacteria, although they are moderate risk bacteria, set the stage, so to speak, for our red complex bacteria.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/  Citations:   Mohanty, R., Asopa, S.J., Joseph, M.D., et al. Red complex: Polymicrobial conglomerate in oral flora: A review. J Family Med Prim Care. 2019; 8(11): 3480-3486. Published 2019 Nov 15. doi:10.4103/jfmpc.jfmpc_759_19   Mohanty, R., Asopa, S. J., Joseph, M. D., Singh, B., Rajguru, J. P., Saidath, K., & Sharma, U. (2019). Red complex: Polymicrobial conglomerate in oral flora: A review. Journal of family medicine and primary care, 8(11), 3480–3486. https://doi.org/10.4103/jfmpc.jfmpc_759_19

Dr. Centor discusses the diagnosis and treatment of pharyngitis in adolescents and young adults with Dr. Jeffrey Linder of Northwestern University.

Hunter Jenkins steps in to tell us about a microbial titan of human dental plaque - Fusobacterium nucleatum. It truly helps nucleate, or organize, the multi-microbial plaque biofilm.

  Summary: Dr. Robert Centor’s Knowledge Food, Part 2!  On this episode of The Curbsiders, we continue our discussion with the legendary Dr. Centor, focusing on pharyngitis and the highly entertaining origin of the Centor Criteria.  Not only do we learn how to dominate pharyngitis, but we also uncover one of Dr. Watto’s knowledge deficits - Lemierre’s Syndrome.  (He owes us a two minute talk on Lemierre’s Syndrome in case you’re wondering. I know I am.) Clinical Pearls: Admit your own limitations!  Many overestimate their skills as a clinical educator. Preadolescents get streptococcal pharyngitis (...or it’s nothing). Adolescents are much more complicated with streptococcus, EBV, CMV, acute HIV, fusobacterium, and multiple other causes. Important: Separate the causes of pharyngitis in preadolescents and adolescents. General rule: Sore throats should not cause rigors; if present then admit patient, obtain blood cultures, and start antibiotics. Do NOT miss a peritonsillar abscess or Lemierre’s Syndrome in acute pharyngitis. Pharyngitis improves within three to five days.  Failure to improve should prompt a more thorough investigation. Lemierre’s Syndrome (1 in 70,000 untreated pharyngitis patients) is septic thrombophlebitis of the internal jugular vein.  The treatment is IV antibiotics and NOT anticoagulation.   Dr. Centor and the IDSA recommends Amoxicillin once daily and, if penicillin allergic, Clindamycin.  The most recent IDSA update recommends a 10-day course of Amoxicillin (50mg/kg up to 1000mg once daily). Dr. Centor’s “Take-Home” Points: Adolescents tend to have more complicated pharyngitis Pharyngitis and rigors?  Admit, obtain cultures, and start antibiotics. Sore throats don’t get worse and, if they do, you need to rethink the case Disclosures: Dr. Centor reports no relevant financial disclosures for this topic. Learning objectives: By the end of this podcast listeners will be able to: Identify the limitations of the Centor Criteria in regards to (a) preadolescents and (b) adolescents, taking special precautions in the adolescent population Understand which acute pharyngitis patients require a more thorough investigation Be able to identify Amoxicillin as the treatment of choice for acute bacterial pharyngitis with Clindamycin as the second-line antibiotics choice. Links from the show: Check our Dr. Centor’s wonderful blog, at http://www.medrants.com or on twitter https://twitter.com/medrants Centor’s Criteria (MDCalc) -- http://www.mdcalc.com/modified-centor-score-for-strep-pharyngitis/ IDSA Guidelines on Diagnosis and Management of Group A Streptococcus Pharyngitis - http://cid.oxfordjournals.org/content/early/2012/09/06/cid.cis629.full.pdf+html Original article using the Centor score for pharyngitis https://www.ncbi.nlm.nih.gov/pubmed/6763125?dopt=abstract Dr. Centor’s article on fusobacterium Centor RM, et al. The clinical presentation of Fusobacterium-positive and streptococcal-positive pharyngitis in a university health clinic: a cross-sectional study. Ann Intern Med. 2015 Feb 17;162(4):241-7. doi: 10.7326/M14-1305.

Summary of the February 17, 2015 issue, including articles on Fusobacterium necrophorum pharyngitis, dietary goals for the metabolic syndrome, systolic blood pressure and chronic kidney disease, risk prediction tools for atherosclerotic cardiovascular disease, opioids and chronic pain, data collection and management for systematic reviews, and clinical documentation in the 21st century, as well as commentaries on Ebola and sharing of clinical trial data.

Überprüfung der Wirksamkeit stallspezifischer Vakzinen zur Bekämpfung der Dermatitis digitalis bei Milchkühen Die Studie wurde als kontrollierter Doppelblindversuch durchgeführt. Die Untersuchungen fanden in einem Milchviehbetrieb in Norddeutschland statt (429 Tiere bei der ersten Untersuchung). Aus den Hautbioptaten typischer DD-Läsionen wurden folgende Erreger im anaeroben Bereich isoliert: Porphyromonas ssp., Porphyromonas levii, Porphyromonas endodonatales, Fusobacterium necrophorum, Bac. stercoris, Prevotella bivis, Peptostreptococcus indolicus, Treponema sp.. Daraus wurden zwei formalininaktivierte Adsorbatvakzinen hergestellt. Die eine enthielt alle Keimarten außer Treponema sp. (Impfgruppe A), die andere alle Keimarten und Treponema sp. (Keimanteil 20 %) aus einer Schüttelkulturvermehrung (Impfgruppe B). Als Placebo wurde die Impflösung ohne Antigen verwendet (Kontrollgruppe). Verabreicht wurden je 5 ml Impfstoff oder Placebo subkutan. Der Klauengesundheitsstatus wurde im Oktober 1998, März 1999, Oktober 1999 und im Januar 2000 im Rahmen der halbjährlich durchgeführten funktionellen Klauenpflege erfasst und die Befunde der Hintergliedmaßen dokumentiert. Die erste Impfung erfolgte im Dezember 1998, die zweite drei Wochen später, die weiteren Impfungen fanden im März 1999 und im November 1999 statt. Zwischen der ersten und vierten Untersuchung durchgeführte Klauen- und Antibiotikabehandlungen wurden vom Betriebsleiter protokolliert. Die Auswertung erbrachte folgende Ergebnisse: 1. Zu keinem der vier Untersuchungszeitpunkte bestanden signifikante Unterschiede bezüglich der Prävalenzen der DD in den zwei Impfgruppen und der Kontrollgruppe. Die Prävalenzen der DD bewegten sich zum Zeitpunkt der vier Untersuchungen um 36 %, 42 %, 51 % und 38 %. 2. An Hintergliedmaßen, die bei der Erstuntersuchung DD-Läsionen aufwiesen, konnten auch bei den Folgeuntersuchungen in den zwei Impfgruppen und der Kontrollgruppe jeweils etwa gleichhäufig derartige Veränderungen diagnostiziert werden. 3. An Hintergliedmaßen, die bei der Erstuntersuchung frei von DD waren, konnten bei den Folgeuntersuchungen in den zwei Impfgruppen und der Kontrollgruppe jeweils etwa gleichhäufig DD-Läsionen diagnostiziert werden. 4. Die Scorewerte (nach DÖPFER, 1994) DD positiver Tiere - als Maßzahl für den Schweregrad der DD-Veränderung - waren zu den vier Untersuchungszeitpunkten in den zwei Impfgruppen und der Kontrollgruppe statistisch nicht signifikant verschieden. 5. Der „maximale gewichtete Flächenindex (max. GFI)“ - als weitere Bewertungsgrundlage für den Schweregrad der DD - war bei den Untersuchungen U2 und U3 in den Impfgruppen und der Kontrollgruppe nicht statistisch signifikant verschieden. Bei U1 war in der Impfgruppe B ein statistisch signifikant höherer Mittelwert (x) festzustellen als in der Kontrollgruppe (x = 82; p = 0,006). Bei U4 war in der Kontrollgruppe ein statistisch signifikant niedrigerer Mittelwert (x) festzustellen als in den Impfgruppen (x = 22,5; p = 0,033). 6. Die Häufigkeit von Klauen- und Antibiotikabehandlungen sowie der Einfluss von DD-Läsionen auf die Abgangsursache waren in den zwei Impfgruppen und der Kontrollgruppe statistisch nicht signifikant verschieden. In der vorliegenden Impfstudie konnte weder eine prophylaktische noch eine therapeutische Wirkung durch die verwendeten stallspezifischen Vakzinen bei der Bekämpfung der Dermatitis digitalis festgestellt werden. Auch das Hinzufügen von Treponema sp. erbrachte keinen Effekt auf die Wirksamkeit des Impfstoffs.