Podcasts about methodsthe

Andrea Donsky, nutritionist, published menopause researcher, menopause educator, and co-founder of WeAreMorphus.com, discusses skincare for women over 40 with Glow Jar Beauty founder Jamie Pereira. They talk about inclusive skincare for all ages, maintaining skin barrier health, the importance of hydration, and streamlining skincare routines.Our podcast has been recognized as the top-ranked menopause podcast worldwide on Feedspot's 2025 list of best Menopause Podcasts and Perimenopause Podcasts.Topics covered:Jamie's journey creating Glow Jar BeautyWhat the skin barrier is and why it's essential for healthy skinHow falling estrogen contributes to dry, crepey skinThe importance of hydration—from the inside out and outside inHow omega-3s and fatty acids support skin healthA guide to auditing your current skincare routine, ingredients, and methodsThe true meaning of “hypoallergenic” and what to know about hormone-disrupting ingredientsNavigating skincare regulations and the clean beauty movementHow to layer products correctly for maximum benefitThe healthy way to exfoliate your face, neck, and chestWhy daily sunscreen use is essential and what to look for in a productProper application of serums and nighttime routinesManaging rosacea and sensitive skinThe role of collagen in skincare—should you take it orally, use it topically, or both?Links:Morphus Omega 3-T https://bit.ly/3rpSFjCNEW Surveys and Men's Perspective of Perimenopause & Menopause: Survey https://bit.ly/4jcVuLhGlow Jar Beauty https://bit.ly/41T4MWiSend us a text ✅ Fill out our surveys

AI isn't just about flashy tools—it's about transforming how AEC firms research, analyze, and make decisions. In this episode of KP Unpacked - the number one Podcast in AEC, Jeff Echols and Frank Lazzaro dive deep into the power of AI research tools and how you can use them to work smarter, not harder.Key takeaways from this episode:Why AI research tools are changing the game for AEC firmsFrank's personal formula for finding 12 minutes of efficiency daily using AIReal-world examples of how AI tools outperform traditional research methodsThe top AI tools you should be using: ChatGPT Deep Research, Storm, and PerplexityHow to avoid AI's common pitfalls in data analysis and research workflowsActionable tips to start using AI research tools in your business todayWe want to tell you about something we've been quietly working on—and now it's live. It's called Catalyst. It's a space built for AEC professionals like you who are designing, building, and reimagining the future. Catalyst is where the sharpest minds in our industry connect, share, and lead what's next. If this sparked something, Catalyst is where we keep the conversation going.This uniquely active space is where the top minds in our industry come together and shape what's next in AEC. Ignite innovation. Join the waitlist at kpreddy.co. Hope to see you there!

In this episode of Agents of Nonprofit, I'm joined by Sharon Lee, a nonprofit leader with over 20 years of experience. With the Canadian Pulmonary Fibrosis Foundation, Sharon challenges outdated industry practices and embraces innovative strategies to increase engagement and funding. Topics We Cover:How Sharon's unexpected career shift led her to nonprofit workThe importance of questioning outdated practices in nonprofit organizationsInnovative fundraising strategies that move beyond traditional methodsThe power of storytelling and advocacy in driving systemic changeOvercoming resistance when introducing new ideas in nonprofitsSustainable community projects and how they empower local populationsServant leadership and its role in creating lasting impactThe future of nonprofit leadership and the importance of ongoing developmentTo Learn More and Connect with Sharon:CPFF.caInfo@CPFF.caSharon Lee on LinkedInSupport the show

Funnel Series #7Quiz funnels have been one of the most profitable tools I've created for clients, and in this episode, we're diving deep into their potential. Joining me is Josh Haynam, CEO and co-founder of Interact, a platform that helps businesses create interactive experiences designed to guide customers toward the right products and services for their unique needs.This conversation builds on what we discussed with Janelle Harlan in episode 228 about segmenting your audience and delivering the right message at the right time. Josh takes it further, sharing how AI is revolutionizing the process by enabling businesses to ask key questions and instantly recommend tailored solutions in real-time.Listen to learn more about:The difference between quiz funnels and chatbots in terms of customer engagement and experienceHow quiz funnels streamline lead generation and customer decision-making compared to traditional marketing methodsThe advantages and potential pitfalls of relying on AI for customer interactions and lead generationHow quizzes and AI chatbots can be more effective by focusing on guiding and understanding customers rather than pushing for sales (and why this approach leads to stronger long-term engagement)This episode is packed with Josh's expert insights into creating interactive experiences that convert. Whether you're working with clients or building your own business, adding quiz funnels to your skill set will help you level up and command premium rates.Sponsored by ActiveCampaign*: Save hours each day by automating your email marketing, allowing you to focus more on growing your business. With AI-powered automations that suggest, personalize, and validate your marketing campaigns, you can streamline your efforts and achieve greater results. Sign up for ActiveCampaign here* with my referral link Links Mentioned in the Show:Take Emily's quiz: Find Your Ideal Marketing Assistant Niche Unlock your potential & find out where your strengths lie and how you can excel in the freelance world.Get started for free with Interact: Use their AI quiz maker to create a beautiful quiz for your brand in a minute.Join The Digital Marketer's Workgroup: Are you already doing marketing work but need more clients and a stronger referral network? Join a tight-knit community of freelancers and get access to behind-the-scenes conversations, support, and troubleshooting that every solo marketer needs. Plus, you'll benefit from advanced trainings, networking opportunities, and exclusive job leads. Apply here!Connect with Josh:Instagram: @tryinteract Facebook:

In this podcast episode, we had the pleasure of speaking with Eric Appelman from Aduro Clean Technologies. Join us to explore how Aduro is revolutionizing plastic recycling with their cutting-edge technology. Key episode highlights:The story behind Aduro Clean Technologies: From Canadian roots to European expansionHow Eric's team is transforming dirty plastic waste into clean, reusable materialsThe advantages of Aduro's low-temperature hydrochemolytic technology over traditional methodsThe role of innovation in driving the circular economyEric's advice for future sustainability professionals: Stay ambitious and optimistic!Don't miss this insightful episode!

How can immigrant entrepreneurs leverage their unique experiences to build generational wealth through real estate?In this episode, Yonah sits down with Bryan Escudero, a first-generation American whose parents immigrated from Colombia. Bryan dives into the challenges and triumphs of navigating the real estate world as a first-generation investor, highlighting the importance of education, strategic partnerships, and the role of cultural background in shaping financial decisions. Bryan's insights offer valuable lessons for anyone looking to make their money work for them, especially those from immigrant backgrounds.[00:01 - 06:08] The Power of Family and CommunityThe quality of relationships, not just financial gainThe importance of a strong family bond for professional achievementsWhat can drive success in business ventures[06:09 - 12:02] First-Generation Success in Real EstateWhy financial education is crucial for first-generation investorsA tangible path to wealth creation beyond traditional savings methodsThe immigrant mindset of hard work[12:03 - 18:12] Balancing a Corporate Career with Real Estate AmbitionsThe freedom to be selective with real estate dealsHow to maintain a fulfilling corporate career while building a real estate portfolioThe role of strategic time management and partnership[18:13 - 24:56] Overcoming Cultural Barriers in Real EstateThe lack of financial information available in languages other than EnglishWhy immigrants face hurdles in accessing reliable investment informationProviding trustworthy resources is crucial for empowering first-gen investors[24:57 - 30:33] Focus and Discipline in Real Estate InvestingAvoiding "shiny object syndrome" is key to long-term success in real estateWhat can help investors focus and achieve investment goalsThe importance of staying true to your mission and goalsConnect with Bryan:Website: www.firstgenfoundations.comLinkedIn: https://www.linkedin.com/in/bryan-escudero/Instagram: https://www.instagram.com/firstgenfoundations/LEAVE A 5-STAR REVIEW by clicking this link.WHERE CAN I LEARN MORE?Be sure to follow me on the below platforms:Subscribe to the podcast on Apple, Spotify, Google, or Stitcher.LinkedInYoutubeExclusive Facebook Groupwww.yonahweiss.comNone of this could be possible without the awesome team at Buzzsprout. They make it easy to get your show listed on every major podcast platform.Tweetable Quotes:"Success means nothing to me if I'm not bringing people along with me." - Bryan Escudero"You don't have to do all the work yourself; learning to delegate and build a strong team is essential." – Bryan EscSupport the Show.

This week's Pathfinder pod features Tony Frazier, LeoLab's newly appointed CEO, to discuss the critical role the company plays in building a living map of orbital activity for space operations. With over $120M of private capital raised, LeoLabs has continued to expand its global network of ground-based radars, currently cataloging over 22,000 objects in LEO. Tony shares his journey from a 13-year career at Maxar to joining LeoLabs, driven by his belief in the company's mission to enhance space safety and security.We explore Tony's background, including his experience managing billion-dollar P&L operations at Maxar and his involvement with Iridium, which shaped his understanding of the risks posed by debris. We also discuss:The founding story of LeoLabsThe unique advantages of ground-based radar network compared to other tracking methodsThe exponential growth in orbital objectsScaling a radar system to meet the demands of a rapidly proliferating LEO environmentThe future of space traffic management and the impact of regulationAnd much, much more… • Chapters •00:00 - Intro00:33 - What is LeoLabs?01:34 - Where is LeoLabs based and how long have they been around?02:42 - How did Tony end up at Leo Labs?04:26 - The mission08:04 - Why LeoLabs hired Tony?09:55 - How important is debris and traffic management?13:52 - The Kessler Syndrome15:48 - LeoLabs' architecture23:08 - Competitor differentiation25:29 - Advantages of a space-based architecture28:14 - Scaling30:09 - 3rd-party data integration32:12 - Current demand for situational awareness and future predictions35:06 - Market catalysts39:38 - How LeoLabs makes money41:41 - Data tracking for the lowest tier subscription44:26 - Government vs commercial bookings44:59 - What makes LeoLabs attractive to investors?48:16 - Is the goal to become a public company?49:26 - Killer asteroids50:07 - Favorite space-related media • Show notes •LeoLab's website — https://leolabs.space/LeoLab's socials — https://twitter.com/LeoLabs_SpaceMo's socials — https://twitter.com/itsmoislamPayload's socials — https://twitter.com/payloadspace / https://www.linkedin.com/company/payloadspacePathfinder archive — Watch: https://www.youtube.com/@payloadspacePathfinder archive — Listen: https://pod.payloadspace.com/episodes • About us •Pathfinder is brought to you by Payload, a modern space media brand built from the ground up for a new age of space exploration and commercialization. We deliver need-to-know news and insights daily to 19,000+ commercial, civil, and military space leaders. Payload is read by decision-makers at every leading new space company, along with c-suite leaders at all of the aerospace & defense primes. We're also read on Capitol Hill, in the Pentagon, and at space agencies around the world.Payload began as a weekly email sent to a few friends and coworkers. Today, we're a team distributed across four time zones and two continents, publishing five media properties across multiple platforms:1) Payload, our flagship daily newsletter, sends M-F @ 9am Eastern2) Pathfinder publishes weekly on Tuesday mornings (pod.payloadspace.com)3) Polaris, our weekly policy briefing, publishes weekly on Tuesdays4) Payload Research, our weekly research and analysis piece,  comes out on WednesdaysYou can sign up for all of our publications here: https://payloadspace.com/subscribe/

In this episode of the Event Tech Podcast, Will Curran and Brandt Krueger dive into the fascinating parallels between the event industry and video games. They explore how concepts from popular games like Fallout can be applied to enhance attendee experiences at events. From the importance of choice and exploration to the potential of gamification, they discuss innovative ideas to keep attendees engaged and satisfied. Plus, they touch on the evolution of event apps and how to gamify actions that truly matter without alienating parts of your audience.Discussions Include:How open-world games like Fallout can inform event designThe balance between too much and too little choice for attendeesThe potential pitfalls of traditional gamification methodsThe importance of meaningful engagement metricsThe future of event apps and wayfinding technologyQuotable Quotes Should You Choose to Share:"I think there's some things that are more metaphorical, more spiritual when it comes to how we design our events. More strategic, there we go- that's maybe a more better, gooder word." - Brandt Krueger"In the same way that we say we want more white space, we want the choice of more white space." - Will Curran"Let's refocus our gamification on the things that actually matter, like networking and engagement with exhibitors." - Will Curran"It's almost worse than not having gamification at all because now I feel deflated." - Brandt Krueger

Since this is one of the topics I get asked the most questions about, I figured it was time to do a whole deep dive episode on birth control. I hope this episode can serve as a non-judgemental, educational, evidence-based resource for you as you navigate making the very personal decision about what type of contraception you choose to use.Listen in to hear me share:The key factors to consider when choosing a birth control methodUnderstanding the ways that different contraceptive devices prevent pregnancyExploring the pros and cons of different hormonal and non hormonal birth control methodsThe impact of hormonal birth control on your mental health, thyroid, nutrient status, fertility, and moreAnswering your most common questions about birth control+ so much more!Connect with LaurenFollow me on Instagram or and head to my website to get 60+ free hormone healthy recipes, download my free Ebook, How to Boost Your Egg Quality, learn about my coaching programs and stay up to date on all my latest workshops and courses!Thank you so much for listening to the About Health and Hormones Podcast! If you loved today's episode, I would love to know! Please leave a rating and review so I can make this podcast even better for you all. I would love to connect with you.I'm so glad you were here today, and I wish you all health and happiness!This episode was edited and produced by Intent Media.

In this special episode, Inventia Life Science Director Sales and Operations, US, Dwayne Dexter, Ph.D., and Thomas & Kipp Gutshall Development Professor Of Chemical & Biomolecular Engineering April Kloxin, Ph.D., join Hannah for a discussion on the current state of 3D cell model challenges and how Inventia's RASTRUM™ Platform is providing solutions. Key Learning Points:The challenges researchers are facing while using 3D models for drug discoveryWhat differentiates 3D printed models from other 3D generative methodsThe solutions Intenvia's RASTRUM™ Platform is providing in this area The future outlook on 3D printed biological modelsAbout  Inventia Life Science:We're Inventia Life Science. We develop solutions to create advanced cell models and help forward-thinking pioneers in the fields of drug discovery and biomedical research to create human tissue for research and therapy.Our machines create advanced cell models which most closely and predictably imitate real human tissue structure and behaviour across a range of disease states. This physiological complexity offers an environment in which world-class research and discovery can occur, right in your own lab.Visit inventia.life to learn more.Stay connected with SLAS:Online at www.slas.orgFacebookTwitter @SLAS_OrgLinkedInInstagram @slas_orgYouTubeAbout SLASSLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building. Upcoming SLAS Events: SLAS Europe 2024 Conference and Exhibition May 27-29, 2024 Barcelona, Spain SLAS 2024 Microscale Innovation in Life Sciences Symposium 11-12 September 2024 Cambridge, United Kingdom SLAS 2024 Sample Management Symposium 16-17 October 2024 Toulouse, France SLAS 2024 Data Sciences and AI Symposium November 12-13, 2024 Cambridge, MA, USA View the full events calendar

There's no ‘one size fits all' approach to divorce, and each separation will take a different path, but how do you decide the best approach to take?When a marriage comes to an end, every choice can feel overwhelming, particularly if children are involved. Whether it's mediation or court, knowing the options that are available to you from the outset can avoid additional cost and time, and ultimately provide better outcomes.Coming together to consider the benefits and drawbacks of each are Zahra Pabani, Clare Wiseman and Claire Filer, Partners in our family law team, and Laura Heaton, Barrister from 29 Bedford Row Chambers. In the podcast they discuss:Navigating the international implications of the divorce processThe increase in alternative dispute resolution methodsThe options available to separating couplesBenefits of court vs mediation cases.

In today's podcast, Simon Gonzalez, a third-generation natural builder, discusses the global potential of natural building using materials like cob and adobe. He introduces the concept of "outposts" for showcasing the potential of these often ancient techniques, emphasises regional education, and addresses logistical challenges in today's world, including legal obstacles. Simon dispels myths about the resilience of natural materials, explores practical applications in urban settings, and promotes a sustainable, pod-style approach to building.We encourage our audience to support this podcast's mission for climate solutions through likes, reviews, and subscriptions!A few takeaways you'll get from this episode:The importance of widespread adoption of natural building methods globallyHow using material alternatives like cob, adobe, and plaster results in more sustainable structures (and benefits health as well!)How people can access education and workshops related to natural building methodsThe concept of "pod style" building - where structures are built incrementally to meet immediate needs and allow for gradual growth over timeOur favourite quote:"Natural buildings are antimicrobial and antifungal. There's a long list of healthy attributes to using these products!" - Simon GonzalezLearn more:Follow Simon on Instagram: @texascobcoVisit Texas Cob Company: www.texascob.comConnect with us on Instagram: @101wayspodVisit our website: www.savetheplanetpodcast.com

In this episode of the Beautiful Business podcast, our host Yiuwin Tsang and Chris Shaw from We Are Atmosphere talk about creating disruption in the consultancy world and overcoming challenges in a saturated market. Chris Shaw highlights the challenges faced by consultancy businesses in the current economic climate, including standing out and identifying pressure points in clients' businesses. Chris and Yiuwin look at ways in which consultancies can develop strategies for business success as well as future-proofing the business through adaptability and creativity.Listen to the podcast now to learn more about: The growing importance of sustainability in business, with a focus on purpose-driven approaches and authenticityFuture-proofing businesses by analysing four areas: society, technology, planet, and ways of workingCreating scenarios to help businesses adapt to rapid change and recognise opportunities, even if change is too fast to predictThe importance of adaptability in business, particularly in the face of existential threats like climate change, economic instability, and geopolitical tensionsThe challenges of disruptive change in business, including a lack of time and energy to focus on the future, and a tendency to prioritise short-term goals over long-term planningHow consultancy leaders should focus on adaptability and being open to new ways of thinking, rather than getting stuck in traditional methodsThe importance of creativity and adaptability in business to stay ahead of new developments and meet sustainability challengesAbout Chris ShawChris is a creative at heart, having spent the last 20 years helping business leaders around the world maximise growth and achieve the results they really want, all against the backdrop of change. During his career, he has built an extensive playbook containing more than 200 unique tools, frameworks and insights all designed to simplify the complex nature of business and facilitate creative thinking.Having successfully built and exited both a management consultancy and a creative agency in the last 10 years, Chris has used his blend of commercial experience and academic insight to accelerate the growth of organisations in a wide range of sectors including SaaS, Finance, Security, Media, Manufacture, Education, Logistics, Marketing, Travel and Professional Services.He has recently ventured into the realm of horror fiction having signed a five-book publishing deal in the young adult space. 

We're back and better than ever! In this episode I share some of the big things I learned in 2023 as a business and agency owner such as:AI is not to be feared, but embraced…strategicallyAutomation can save you countless hours, and is dirt cheapNot everyone is cut out to work remotelyIf you're good at what you do, you'll survive economy downturnsThe best way to differentiate yourself in today's world is to embrace traditional methodsThe agency game is changing. Consolidation, acquisitions and extreme niche'ingDouble down on investing time and effort on your personal brand…it follows and supports you always and foreverNow is the best time in the history of everything to start your own businessLearn more:www.socialistics.comwww.jasonyormark.comwww.antiagencybook.com

It's not easy to sell things. It's even harder to sell to security practitioners and leaders. The Great Security Debate this week covers some angles in security tools (and selling those tools to security teams) that have taken their toll on the trust that needs to exist between those who buy and those who make the products that we use. From the software providers to the VAR (resellers) in the middle to the people and techniques used to market and sell the solutions. Some of the key topics of the discussion include:The challenges of security tool consolidation by non-security vendorsSecurity is not a lock-in tool, and security is not an upsell toolPushing changes to products without telling the customers before they happen or letting those customers have control over the change (and if they take it or not)Security Selling with VARs & Deal Registration What are the motivators when a product is recommended to youYou can still buy direct (and why you might want to)The challenge of selling into the SMBThe power of the “vouch” that flies in the face of some sales methodsThe importance of being genuine in sales communications (aka knock off the programmatic drip campaigns that pretend to be personal)Some of the links in the show notes contain affiliate links that may earn a commission should you choose to make a purchase using these links. Using these links supports The Great Security Debate, so we appreciate it when you use them. We do not make our recommendations based on the availability or benefits of these affiliate links.Thanks for listening!

XR Today's Demond Cureton hosts Seth J Bennett, CMO, Charlotte Hornets, James Kaplan, CEO and Co-Founder, MeetKai, and Weili Dai, Executive Chairwoman and Co-Founder, MeetKai.In our interview, we discuss the following:The impetus for MeetKai and the Charlotte Hornets to collaborate for their virtual sports apparel storeUsing MeetKai's XR solutions to engage sports fans in fresh and innovative waysHow using XR and the Metaverse can lead to greater engagement rates compared to traditional methodsThe rising trend in sports companies leveraging Web3 and Metaverse technologies to boost brand engagementDemocratising immersive experiences for sports fans with interoperable technologies to reach the widest audiences possibleEmerging trends in XR and what could take place in the future

James and the crew sit down to reminisce on the early days of moose hunting and the hard lessons learned through trial and error. Today's discussion includes:SE Alaska wolves saved from ESAFour-wheeler use in the woodsTerrain and hunt methodsThe floating moose

On this week's episode of In The Circle, James asks a question of great concern to many people as they embark on their journey of discovery in recovery—How can a person with religious or relational trauma find their place in modern-day recovery?Together, James and I highlight the plethora of challenges one can encounter on the road to recovery—from cultural misconceptions to financial barriers, why it's crucial for everyone to take their own unique approach to healing and recovery, and the essential pillars of transformation.This episode stands as guidance for others on their recovery journeys, emphasizing the importance of staying true to oneself, embracing open-mindedness, and demonstrating resilience in the face of unique challenges. I believe that consistency and truly honoring one's personal journey are the ultimate keys to freedom.Tommy discusses:The cultural misconceptions of alternate recovery methodsThe essential pillars of transformation The importance of open-mindedness and staying true to oneselfThe fine line between conscious surrender and giving away one's powerWhy community is so important in recoveryHow to find a community that supports you and your own, unique pathConnect with TommyInstagramFacebookTikTokAddiction is part of everyone's journey, but recovery is not. The Recovery 2.0 Membership is a place where you can explore the topics that interest you, find community, and connect with Tommy Rosen on a personal level. It's here that we'll dig into spirituality and union of the mind, body, and spirit, and transform from the inside out. You will learn and grow alongside a community of supportive, conscious, compassionate, and vibrant individuals, like you!Join us at r20.com/welcome to explore how to move beyond addiction and thrive in your life.Come and experience an in-person event or retreat: r20.com/events@Recovery2Point0 on InstagramRecovery 2.0 Facebook GroupIn The Circle is produced by Lovemore Media.

Disclaimer: The information provided in this podcast is not a substitute for professional medical advice. Listeners are encouraged to consult with qualified healthcare providers for personalized recommendations.In today's episode, we are joined by a special guest, Esther Blum, an integrative dietitian and menopause expert and together we dive into the world of menopause and perimenopause, shedding light on this often misunderstood phase of life for women. Here's a breakdown of what you can expect from this insightful conversation:The frustration with conventional medical approaches and seeking alternative methodsThe importance of questioning research sources and understanding biasThe need for transparency and advocating for your healthEmpowering women to take control of their health and question medical recommendationsMonica's personal experience with hormonal imbalance and how it led to the creation of her brand, MareaEsther's journey into the field of menopause and integrative dietetics.The lack of support and focus on menopausal women in conventional medicineAddressing the evolving perspective on menopause and the changing landscape of healthcareRecognizing the signs of perimenopause, including changes in menstrual cycle, weight gain, hot flashes, etcFactors influencing hormone balanceThe impact of trauma on hormone balance and the importance of healing.The misconception around the duration of menopause and addressing symptoms.Differentiating between induced symptoms due to diet changes and genuine perimenopausal symptomsApproaches to raising progesterone levels and managing hormonal changes.The ongoing nature of menopausal symptoms if not addressed properly.The long-term effects of a hysterectomy without proper hormone replacement therapyThe role of vaginal estrogen and treatments for menopausal vaginal healthAnd so much more!Connect with Esther:Website: https://estherblum.com/Instagram: @gorgeousestherAbout Esther Blum:Esther Blum is an Integrative Dietitian and Menopause Expert. In the past 27 years she has helped thousands of women master menopause through nutrition, hormones and self-advocacy.Esther is the bestselling author of See ya later, Ovulator, Cavewomen Don't Get Fat, Eat, Drink and Be Gorgeous, Secrets of Gorgeous, and The Eat, Drink, and Be Gorgeous Project.Learn more about Marea: http://www.mareawellness.com/Connect with The Flow State Podcast Hosts:Norah Candito, registered dietitian: @nutritionwithnorahEmail: nutritionwithnorah@gmail.comWebsite: https://www.nutritionwithnorah.com/Join Norah's group program for personalized support on your hormonal health journey:https://www.nutritionwithnorah.com/harmonizeMonica Grohne, Marea's founder, PMDD warrior and wellness junkie: @monicagrohneWant to connect with other like minded wellness girlies? Join the 

By Peter BowesImagine reconnecting with an old school friend, reminiscing about the good old days, and discovering you share a deep interest in health and longevity? That's exactly what happened when I caught up with Peter Allison, my classmate from the 1970s. We took a trip down memory lane, discussing our school days  - the good, the bad and the ugly - including our knack for avoiding physical education by playing chess. Beyond the nostalgia, Peter and I explored how to optimize our health as we age, and what we've learned so far. This is the first of a regular series of conversations, not so much turning back, but looking forward to the next chapter in our lives. Peter A. is a geology professor, well used to analyzing scientific papers, and together we will be casting our inquisitive but critical eyes over the latest longevity research.Topics covered in this conversation include:Peter Bowes and Peter Allison discuss their school days and memories of their time together, including their shared dislike of physical education and love of learning.Peter A. recounts the encouragement he received to chase his dreams and how aging could impact his physical aspirations moving forward.Peter A. shares his career journey as an academic and geologist, highlighting his passion for ecological research and diving.Challenges with weight and muscle loss as we grow older,The importance of finding a project to focus on during retirement and shared the lessons learned in pursuit of personal growth.Experimenting with fasting methodsThe importance of resistance training and weight lifting, and how it can help us maintain our health as we age.New research: The potential benefits of taurine for extending life and improving health, noting the dosage of taurine required for potential benefits is much higher than would be practical for human consumption. New research: Napping and long life, plus the role genetics play in our sleep sensitivities. DISCOUNTS▸ The aging process affects our cells much earlier than you might think - it leads to a slower metabolism, lower energy and weaker muscles.  The Swiss longevity brand Time-line is offering LLAMA podcast listeners a 10% discount on its Mitopure products - Mitopure Powder, Softgels and Mitopure + Protein. Mitopure supports improvements in mitochondrial function and muscle strength. Use the code LLAMA at checkoutFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifyAffiliation disclosure: This site includes affiliate links from which we derive a small commission, if you click on the product links and use the code LLAMA at checkout. This helps support the channel and allows us to continue sharing conversations like this. LLAMA is available, free of charge, wherever you get your podcasts. Our mission is to explore the science and lifestyle interventions that could help us live longer and better. Thank you for the support!Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.21.537899v1?rss=1 Authors: Khotina, V. A., Kalmykov, V. A., Zhuravlev, A. D., Sinyov, V. V., Sobenin, I., Orekhov, A. N., Sukhorukov, V. N. Abstract: BackgroundIt was assumed that the cause of chronic inflammation in atherosclerosis is a disturbance of the innate immunity response, caused, among other factors, by mitochondrial dysfunctions. It was also suggested that mitochondrial dysfunction may be caused by heteroplasmic mutations in mitochondrial DNA. The aim of this study was to evaluate the effect of the mitochondrial nonsense mutation m.15059G greater than A on cellular functions in atherosclerosis: lipoidosis, pro-inflammatory response, and mitophagy. MethodsThe human monocytic cell line THP-1 and cytoplasmic hybrid cell line TC-HSMAM1 were used. An original approach based on the CRISPR/Cas9 system was developed and used for the elimination of mtDNA copies carrying the m.15059G greater than A mutation in the MT-CYB gene. Using this approach, the Cas9-TC-HSMAM1 cells with an eliminated m.15059G greater than A mutation was obtained. The gene expression levels of genes encoding enzymes related to cholesterol metabolism were analyzed by quantitative RT-PCR. The evaluation of pro-inflammatory cytokine secretion was assessed using ELISA. Mitophagy in cells was detected using confocal microscopy. ResultsIn contrast to intact TC-HSMAM1 cybrids, in Cas9-TC-HSMAM1 cells, incubation with atherogenic LDL led to a decrease in the expression of the gene encoding fatty acid synthase (FASN). It was found that TC-HSMAM1 cybrids are characterized by defective mitophagy and are also unable to reduce the production of pro-inflammatory cytokines (to form immune tolerance) in response to repeated LPS stimulation. Elimination of mtDNA carrying the m.15059G greater than A mutation led to the restoration of immune tolerance and activation of mitophagy in the studied cells. ConclusionsThe m.15059G greater than A mutation was found to be associated with defective mitophagy, immune tolerance, and impaired metabolism of intracellular lipids due to upregulation of the FASN. Thus, this mutation may play an important role in atherogenesis due to its contribution to the chronification of inflammation, which aggravates the progression of atherosclerosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Today's episode features a discussion with Chris Pieta (@chris.pieta), a product photographer and the founder of "Pieta Productions", a company that helps brands stand out online by providing them with authentic and captivating video and photo content. In today's episode, our talk focuses on but isn't limited to:The threats and opportunities with AI and photographyTraining our brains to treat effort as the reward rather than the resultSystemizing and rationally developing our client approach methodsThe dichotomy between attention to detail and procrastinationCreating good healthy habits from the ground upYou can visit Chris's website here: https://www.creativebizlaunch.com/You can find Chris's Youtube here:  https://www.youtube.com/chrispietaYou can download Chris's ChatGPT Cheatsheet here:  https://www.creativebizlaunch.com/chatgpt-cheatsheetThanks to Tamron Americas for sponsoring this episode! You can check out their website below to see their full lineup of camera lenses or visit your nearest photo retailer to purchase their products:https://tamron-americas.com/Thanks to iStorage for sponsoring the a section of this episode!Check out their External Password Encrypted Hard Drives : https://www.istorage-us.com/Use Code "TPM15" for a 15% discount!Make a donation via PayPal for any amount you feel is equal to the value you receive from our podcast episodes! Donations help with the fees related to hosting the show: https://www.paypal.com/donate/?hosted_button_id=Z36E4SCB6D3LWIf you wanted to find out what kind of personality type you are and where some typical strengths and weaknesses of yours may lie you can head over to 16 Personalities and take their test entirely for free: https://www.16personalities.com/Thanks for listening!Go get shooting, go get editing, and stay focused.@sethmacey@mantis_photography@thephotographermindsetSupport the show

Episode Highlights With AaronHis own amazing story with adoption and using functional medicine to help his childrenHow he was able to use these techniques to help his daughter who they were told would never walk or talk or even crawlFascinating therapies he learned about for his daughter that are helpful to many of his other patientsMore reasons to avoid processed foods and vegetable oils and how these foods can affect the brainHis foundational principles of health that are important before considering more advanced methodsThe real data on omega-3 and omega-6 balanceWhat happens when we consume too much omega-6 and how this affects the brainWhy vegetable oils are partially plasticized and how these integrate into the cell membranes and hormonesWhy women actually need more protein per pound of bodyweight than menThe average American is dehydrated and how this impacts health on many levelsHow trace minerals can improve healthWhat peptides are and how he uses them with his children and with patientsHow peptides can tell hormones what to doInsulin was the first peptide we started using at large scaleWhy being hypermobile in kids comes with a 400% increase in chance of spectrum disorders and what to learn from thisHow the body is electric and how to support your body's electrical systemThe science of meditation and how it physically improves health in a profound wayResources We MentionDr. Hartman - websiteEidon trace mineralsMan's Search for Meaning by Viktor E. Frankl

An in-depth look at ancient Greek practices for profound, lasting healing• Explores hidden soul-healing practices including dream incubation and interpretation as well as sacred pilgrimage• Examines how dreams, visions, and other non-normative events reveal the conditions needed to restore the soul and facilitate healing• Includes successful healing techniques, practices, and case studies to reveal how healings are achieved with these methodsThe modern practice of medicine and psychology grew out of the ancient Greek healing tradition, said to be founded by Asklepios, god of healing and dreams. For two thousand years the system spread all over the Mediterranean world and planted the roots of Western medicine and psychology by offering ritual and holistic practices that recognized that healing begins at the soul level. Yet, since that time, the spiritually based practices were cast aside, leaving behind only the scientific medical techniques that dominate health care today.Resurrecting and restoring the sacred, mythological, and cultural origins of medicine and psychotherapy, Edward Tick, Ph.D., explores the soul-healing practices missing in our contemporary health systems. He looks at the dream incubation tradition of Asklepios, sacred theater of Dionysos, oracle gifting of Apollo, special practices of warriors, and their roots in Neolithic shamanism and indigenous traditions. Demonstrating the ritual use of dreams, visions, oracles, synchronicities, and pilgrimage for healing and connecting to the transpersonal and divine, he explains how dream incubation is a technique in which you plant a seed for a specific healing or growth goal.Using both ancient wisdom and modern depth psychology alongside stories of healings from his more than 25 years of guiding Vietnam veterans on Greek pilgrimages, Tick explores how we all can use ancient healing philosophies and practices to achieve holistic healing today. He examines the interaction between mind and body (psyche and soma) and between physical illness and the soul to heal PTSD and trauma. He explains the art of making accurate and holistic interpretations of signs, symbols, and symptoms to determine what they reveal about the soul. Showing how dreams and other transpersonal experiences are essential components of soul medicine, the author reveals how restoration of the soul facilitates true healing.Edward Tick, Ph.D., is a transformational psychotherapist, international pilgrimage guide, educator, author, and poet. A specialist in archetypal psychotherapy and the healing of violent trauma, he is the author of four nonfiction books, including The Practice of Dream Healing and War and the Soul. He lives in central Massachusetts.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.15.528700v1?rss=1 Authors: Stoner, A., Fu, L., Nicholson, L., Zheng, C., Toyonaga, T., Spurrier, J., Laird, W., Cai, Z., Strittmatter, S. M. Abstract: BackgroundCellular prion protein (PrPC) is a high-affinity cell-surface receptor for Amyloid-{beta} oligomers (A{beta}o). In certain overexpression models of Alzheimers Disease (AD), pharmacology and genetics demonstrate its essential role for synaptic plasticity impairment, memory deficits and synapse loss. However, PrPCs role in AD-related phenotypes with endogenous expression levels, its role in tau accumulation and its effect on imaging biomarkers are unknown. The necessity of PrPC for transcriptomic alterations driven by A{beta} across cell types is unexplored. MethodsThe role of PrPC was examined as a function of age in homozygous AppNL-G-F/hMapt double knock-in mice (DKI). Phenotypes of AppNL-G-F/hMapt mice with a deletion of Prnp expression (DKI; Prnp-/-) were compared with DKI mice with intact Prnp, mice with a targeted deletion of Prnp (Prnp-/-), and mice with intact Prnp (WT). Phenotypes examined included behavioral deficits, synapse loss by PET imaging, synapse loss by immunohistology, tau pathology, gliosis, inflammatory markers, and snRNA-seq transcriptomic profiling. ResultsBy 9 months age, DKI mice showed learning and memory impairment, but DKI; Prnp-/- and Prnp-/- groups were indistinguishable from WT. Synapse loss in DKI brain, measured by [18F]SynVesT-1 SV2A PET or anti-SV2A immunohistology, was prevented by Prnp deletion. Accumulation of Tau phosphorylated at aa 217 and 202/205, C1q tagging of synapses, and dystrophic neurites were all increased in DKI mice but each decreased to WT levels with Prnp deletion. In contrast, astrogliosis, microgliosis and A{beta} levels were unchanged between DKI and DKI; Prnp-/- groups. Single-nuclei transcriptomics revealed differential expression in neurons and glia of DKI mice relative to WT. For DKI; Prnp-/- mice, the majority of neuronal genes differentially expressed in DKI mice were no longer significantly altered relative to WT, but most glial DKI-dependent gene expression changes persisted. The DKI-dependent neuronal genes corrected by Prnp deletion associated bioinformatically with synaptic function. Additional genes were uniquely altered only in the Prnp-/-or the DKI; Prnp-/- groups. ConclusionsA functional Prnp gene is required in AppNL-G-F/hMapt double knock-in mice for synapse loss, phospho-tau accumulation and neuronal gene expression. These data support the efficacy of targeting the A{beta}o-PrPC interaction to prevent A{beta}o-neurotoxicity and pathologic tau accumulation in AD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.29.518315v1?rss=1 Authors: Frorup, C., Gerwig, R., Sondergaard Svane, C. A., Mendes Lopes de Melo, J., Floyel, T., Pociot, F., Kaur, S., Storling, J. Abstract: ObjectiveEndoC-{beta}H5 is a newly established human beta-cell model which may be superior to previous models of native human beta cells. Exposure of beta cells to proinflammatory cytokines is a widely used in vitro model of immune-mediated beta-cell failure in type 1 diabetes and we therefore performed an in-depth characterisation of the effects of cytokines on EndoC-{beta}H5 cells. MethodsThe sensitivity profile of EndoC-{beta}H5 cells to the toxic effects of the pro-inflammatory cytokines interleukin-1{beta} (IL-1{beta}), interferon {gamma} (IFN{gamma}) and tumour necrosis factor- (TNF) was examined in titration and time-course experiments. Cell death was evaluated by caspase 3/7 activity, cytotoxicity, viability, TUNEL assay and immunoblotting. Mitochondrial function was evaluated by extracellular flux technology. Activation of signalling pathways and major histocompatibility complex (MHC) class I expression were examined by immunoblotting, immunofluorescence, and real-time quantitative PCR (qPCR). Glucose-stimulated insulin secretion (GSIS) and cytokine-induced chemokine secretion were measured by ELISA and Meso Scale Discovery multiplexing electrochemiluminescence, respectively. Global gene expression was characterised by stranded RNA sequencing. ResultsCytokines increased caspase activity and cytotoxicity in EndoC-{beta}H5 cells in a time- and dose-dependent manner. The proapoptotic effect of cytokines was primarily driven by IFN{gamma}. Cytokine exposure caused impaired mitochondrial function, diminished GSIS, and induced secretion of chemokines. At the signalling level, cytokines increased the phosphorylation of signal transducer and activator of transcription 1 (STAT1) but not c-jun N-terminal kinase (JNK) and did not cause degradation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (I{kappa}B). MHC class I was induced by cytokines. Cytokine exposure caused significant changes to the EndoC-{beta}H5 transcriptome including upregulation of HLA genes, endoplasmic reticulum stress markers, and non-coding RNAs. Among the differentially expressed genes were several type 1 diabetes risk genes. ConclusionsOur study provides detailed insight into the functional and transcriptomic effects of cytokines on EndoC-{beta}H5 cells. This knowledge will be helpful for future investigations studying cytokine effects in this cell model. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

When I see people that are doing extraordinary things in their business, whether it's a membership, coaching program, or course, I want to bring them to you. This is so that we can unpack what they are doing that's working so you can take some tips and apply them to your business. In this episode of Art of Online Business I sat down with Faye Cornhill, one of my Accelerator coaching members, who runs a very successful wedding membership business. She's here to share why her membership works and what sets her business apart from other wedding-based memberships out there. Faye Cornhill is a business coach to the wedding industry. With her signature mix of positivity, motivation and common sense, she specialises in helping aspirational business owners follow their dreams of making it in the world of weddings.Faye has an incredible retention rate and she shares how she makes that happen in this episode. She also shares more about her launch methods and how much she works in her business. In this episode, you'll learn:Why Faye decided to start a membershipHow she prices her programThe importance of having a sounding boardHow she maintains a high retention rateHow she encourages independence in her membersHer launch methodsThe conversion rates she sees with her launchesHow she gets people into an annual membershipThe freedom she gets because of her businessThe charity she started Links & Resources:The Art of Online Business websiteDM me on InstagramVisit my YouTube channelThe Art of Online Business clips on YouTubeFull episodes of The Art of Online Business Podcast on YouTubeThe Art of Online Business Podcast websiteCheck out my Accelerator coaching program*Disclosure: I only recommend products I use and love and all opinions expressed here are my own. This post may contain affiliate links that at no additional cost to you, I may earn a small commission.Faye Cornhill's Links:Visit Faye's websiteFollow Faye on InstagramFull show notes available at www.rickmulready.com/655

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.12.511145v1?rss=1 Authors: Goudswaard, L. J., Williams, C. M., Khalil, J., Burley, K. L., Hamilton, F., Arnold, D., Milne, A., Lewis, P. A., Heesom, K. J., Mundell, S. J., Davidson, A. D., Poole, A. W., Hers, I. Abstract: BackgroundPatients with coronavirus disease-19 (COVID-19) are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality. ObjectivesWe aimed to characterise the mechanism of altered platelet function in COVID-19 patients. MethodsThe platelet proteome, platelet functional responses and platelet-neutrophil aggregates were compared between patients hospitalised with COVID-19 and healthy control subjects using Tandem Mass Tag (TMT) proteomic analysis, Western blotting and flow cytometry. ResultsCOVID-19 patients showed a different profile of platelet protein expression (858 altered out of 5773 quantified). Levels of COVID-19 plasma markers were enhanced in COVID-19 platelets. Gene ontology (GO) pathway analysis demonstrated that levels of granule secretory proteins were raised, whereas some platelet activation proteins, such as the thrombopoietin receptor and PKC, were lowered. Basally, COVID-19 platelets showed enhanced phosphatidylserine (PS) exposure, with unaltered integrin IIb{beta}3 activation and P-selectin expression. Agonist-stimulated integrin IIb{beta}3 activation and PS exposure, but not P-selectin expression, were significantly decreased in COVID-19 patients. COVID-19 patients had high levels of platelet-neutrophil aggregates, even under basal conditions, compared to controls. This interaction was disrupted by blocking P-selectin, demonstrating that platelet P-selectin is critical for the interaction. ConclusionsOverall, our data suggests the presence of two platelet populations in patients with COVID-19: one with circulating platelets with an altered proteome and reduced functional responses and another with P-selectin expressing neutrophil-associated platelets. Platelet driven thromboinflammation may therefore be one of the key factors enhancing the risk of thrombosis in COVID-19 patients. Essentials- COVID-19 patient platelet function and platelet proteins were compared with healthy controls - Proteomic analysis of platelets indicated that COVID-19 decreased platelet activation proteins - Agonist induced PS exposure and integrin IIb{beta}3 activation were impaired in COVID-19 - COVID-19 led to maximal levels of P-selectin dependent platelet-neutrophil aggregates Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

To understand the future of the market research industry, my guest is Tom Smith, Founder and CEO of GWI. Having spent several years working agency side, he recognised a growing demand for global data to better understand the complex online market, coupling the world's largest ongoing study on the digital consumer with powerful analytics. GWI is now the leading provider of digital consumer insights to the global marketing industry.My favourite section of the podcast was where Tom said"People think data is the new oil, and we're all sitting on this very valuable commodity. The better comparison is that data is like sand. Until you do something with the information, it lacks real value. It's the processing it's the presentation, it's the aggregation and millions of people's data aggregated at scale is a highly valuable product."Tom argues that the market research industry has utterly failed the needs of its consumers in today's global marketplace - this is a bold statement and something Tom addresses in detail in this episode.In this episode, we look at:Why Tom started GWIThe changing needs of the market research industryHow traditional market research methods have evolvedWhat problems GWI solvesHow Ad blockers, GDPR and other regulations have changed collection methodologyWhere AI fits into modern market research methodsThe future of market researchBeing an EntrepreneurMore on TomLinkedInTwitterGWI WebsiteYour Host: Actionable Futurist® Andrew GrillFor more on Andrew - what he speaks about and replays of recent talks, please visit ActionableFuturist.comfollow @AndrewGrill on Twitteror @andrew.grill on Instagram.

Not everyone has the willpower to trust their gut instincts. When faced with something significant or something we have never dealt with before, we prefer to trust someone's word over our own instincts. In this episode of Decide It's Your Turn™, Lauren Cunningham joins Christina to discuss why following your gut is crucial to live a life you love. Lauren demonstrates example after example of deciding it's her turn, taking action and never giving up in her life endeavors. Stay tuned and be inspired!In this episode you will learn: Lauren's story that launched her into her own health journeyWhat is crohn's diseaseHow Lauren started incorporating holistic methodsThe power behind mindset and visualization methodHow Lauren began to heal herself Sign up for the Decide It's Your Turn Mastermind! If you enjoyed this episode, make sure and give us a five star rating  and leave us a comment on iTunes, Podcast Addict, Podchaser and Castbox about what you'd like us to talk about that will help you realize that at any moment, any day, you too can decide, it's your turn! Christina Lecuyer's Bio:Christina Lecuyer is a former Professional Golfer, a three-time reality television competitor, Confidence + Mindset Coach, Motivational Speaker, and Founder of Women with C.L.A.S.S. Mastermind, as well as Decide It's Your Turn: Women's Weekend. Christina's mission in life is to empower people to fully live in their purpose, confidently and successfully! Decide It's Your Turn! PodcastResources and Links:Christina Lecuyer's WebsiteFollow us on InstagramFollow us on FacebookLooking for our Tweets?Christina Lecuyer on YouTubeHashtags : #justbe #worthaf #livealifeyoulove     

In this episode of Illuminate Higher Education, your host and CEO at N2N Services, Kiran Kodithala, interviews Mary Beth Marks, Vice President for Admissions and Enrollment Services at The University of New Orleans.In her senior position within enrollment management — and one of the leading voices in higher education — we wanted to know her thoughts around some of the leading trends for admissions from a student and parent perspective, and the future of enrollment and admission management.Discover what measures The University of New Orleans are considering with regards to the Covid crisis, and what type of overall support they offer students.Learn about:What goes into the admission decision processThe role of technology in the changing landscape of the enrollment process, and how to accommodate students using mobile phones or computers in this sphere, instead of the traditional methodsThe new forms of learning and trends in centric learning methodologiesResources Mentioned:NIHKahootNetflixBlackboardCourseraKhan AcademyThis episode is brought to you by N2N’s Illuminate App, The iPaaS for Higher Education. Learn more at https://illuminateapp.com/web/higher-education/Subscribe and listen to more episodes at IlluminateHigherEducation.com

Adam Carswell hosts the first-ever exclusive Next Level State of the Union address in which he discusses interesting and educational topics that audience members want to know about as well as key takeaways he learns from experiences in his everyday life. In this episode, Adam talks about:Key takeaways from Grant Cardone's 10X Growth ConferenceThe value behind “thinking small” that A-Rod sharesWhy being “repulsive” to non-supporters of your aspirations is actually greatThe value of cryptocurrency and BlockFi compared to traditional savings methodsThe trending market for Non-Fungible Tokens (NFTs)Adam would like to give a huge thanks to everyone who tuned in on Facebook Live during this Next Level State of the Union, contributing their most valuable resource—their time.Watch the Youtube replay here: https://youtu.be/84g3wf8Xl4gDream Chasers episodes mentioned:Grant Cardone: Undercover Billionaire Taking it to the Next Level  |  Fundamentals of Cryptocurrency  Timestamped Shownotes:03:35 – Host Adam Carswell introduces what these exclusive State of the Union addresses are all about05:11 – How can people take their presentations to the next level as a “hybrid event”?06:18 – What inspired New York Yankees player Alex Rodriguez's best hitting streak of his career?08:20 – What does it mean to “think small”?10:18 – Why would you want to become “repulsive” to those who don't support your endeavors?11:16 – What powerful entity did Grant Cardone stand up to in his closing keynote speech at 10X Growth Conference 2021?14:05 – What is BlockFi and how does it protect and generate wealth compared to traditional savings accounts that actually devalue your money?16:29 – What are Non-Fungible Tokens (NFTs) and how are they trending in the current market?23:00 – What new pursuit is Adam taking on with Austin Linney, produced by Anthony Vicino?Sponsored by:  High-Rise Capital (Download their free eBook More Doors, More Profits!)Support the show (https://www.patreon.com/dreamchasers_ix)

THE EPIDEMIOLOGICAL AND ECONOMIC IMPACT OF A POTENTIAL OUTBREAK OF FOOT-AND-MOUTH DISEASE IN AUSTRIAIntroductionAn outbreak of foot-and mouth disease (FMD) in an FMD-free country with substantial export volume of livestock and livestock products, such as Austria, would likely have serious consequences on national economy. This could be mitigated by a rapid intervention to control disease spread. The objectives of this study were to assess the epidemiological and economic impact of FMD outbreaks in Austria by simulation studies, to evaluate the effect of various control strategies and to assess the resources that would be required to respond to an FMD outbreak in Austria.Materials and methodsThe multi-country FMD outbreak simulation model EuFMDiS was used to simulate a potential FMD outbreak in Austrian regions with both low and high livestock densities. The consequences on the Austrian economy were evaluated by a model, which combines the economic results from EuFMDiS with our own calculation of costs. Direct costs linked to the implementation of several control strategies under consideration, as well as the indirect costs caused by production losses and international trade restrictions were estimated. A sensitivity analysis was performed on potential influential input parameters. ResultsThe results showed that there is a significant influence of the livestock density of the affected region on the dynamics of the outbreak and its economic impact. Comparison of different control strategies suggested that, from an economic point of view, implementation of additional control measures would be efficient if the epidemic started in an area with high livestock density. Analysis of the simulations demonstrated that success of control measures depends substantially on the adequate availability of resources and the speed of intervention. The vast majority of financial losses associated with an FMD outbreak could be attributed to export losses. Surveillance cost accounted for the largest share of the costs linked to the control strategies. DiscussionThe current study indicates that control of an FMD outbreak may be improved by implementation of a contingency strategy adapted to the affected region and by consideration of a range of factors evaluated in this work. T. Marschik1, I. Kopacka2, S. Stockreiter3, F. Schmoll4, J. Hiesel5, A. Höflechner-Pöltl3, A. Käsbohrer1, B. Pinior11 Institute of Food Safety, Food Technology and Veterinary Public Health, Unit of Veterinary Public Health and Epidemiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria2 Division for Data, Statistics and Risk Assessment, Austrian Agency for Health and Food Safety (AGES), Zinzendorfgasse 27/1, 8010 Graz, Austria3 Department for Animal Health and Animal Disease Control, Federal Ministry of Labour, Social Affairs, Health and Consumer Protection, Radezkystraße 2, 1030 Vienna, Austria4 Division for Animal Health, Austrian Agency for Health and Food Safety (AGES), Robert-Koch-Gasse 17, 2340 Moedling, Austria5 Department of Veterinary Administration, Styrian Provincial Government, Friedrichgasse 9, 8010 Graz, Austria