Podcasts about macroscopic

If you were curating a mixtape that might be heard by aliens billions of years from now - but definitely would be seen by your fellow Earthlings - what would you put on it? In 1977, two Voyager spacecraft launched from Cape Canaveral on a journey that would take them beyond our solar system. Affixed to the side of these two planetary explorers was the Voyager Golden Record — the ultimate mixtape of humanity — containing 27 pieces of music as well as pictures and sounds of Earth. But how did these selections get made? Nearly 50 years later, we're teaming up with our friends at the Smithsonian National Air and Space Museum's podcast, AirSpace, to explore what's on the record, how it got made, and its legacy.Learn more about AirSpace! Airspace Hosts: Matthew Shindell, curator of space history at the Smithsonian's National Air and Space MuseumEmily Martin, planetary geologist at the Smithsonian's National Air and Space MuseumGuests:Ann Druyan, Voyager Golden Record Creative DirectorLawrence Azerrad, Co-founder of Macroscopic

We sit down with Dr Amy Maltry to discuss her roles as an ophthalmic pathologist, cataract surgeon and Minnesota state society President. We appreciated the role of pathology in her ophthalmology practice and residency program. After discussing the microscopic aspect of eyecare we zoomed out to reflect on state societies. Dr Maltry encouraged involvement in our professional societies as we collaborate to advance ocular health and outcomes for patients.   Subscribe to the podcast: https://mayoclinicophthalmology.podbean.com  Follow and reach out to us on IG and X: mayocliniceye 

I will discuss Effective Field Theories that can originate from microscopic unitary theories, and their relation to moment theory. I will show that massive gravity, theories with isolated massive higher-spin particles, and theories with very irrelevant interactions, don't posses healthy UV completions, and I will show how Vector Meson Dominance follows from such first principles.

Dario Amodei is the CEO of Anthropic, the company that created Claude. Amanda Askell is an AI researcher working on Claude's character and personality. Chris Olah is an AI researcher working on mechanistic interpretability. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep452-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https://lexfridman.com/dario-amodei-transcript CONTACT LEX: Feedback - give feedback to Lex: https://lexfridman.com/survey AMA - submit questions, videos or call-in: https://lexfridman.com/ama Hiring - join our team: https://lexfridman.com/hiring Other - other ways to get in touch: https://lexfridman.com/contact EPISODE LINKS: Claude: https://claude.ai Anthropic's X: https://x.com/AnthropicAI Anthropic's Website: https://anthropic.com Dario's X: https://x.com/DarioAmodei Dario's Website: https://darioamodei.com Machines of Loving Grace (Essay): https://darioamodei.com/machines-of-loving-grace Chris's X: https://x.com/ch402 Chris's Blog: https://colah.github.io Amanda's X: https://x.com/AmandaAskell Amanda's Website: https://askell.io SPONSORS: To support this podcast, check out our sponsors & get discounts: Encord: AI tooling for annotation & data management. Go to https://encord.com/lex Notion: Note-taking and team collaboration. Go to https://notion.com/lex Shopify: Sell stuff online. Go to https://shopify.com/lex BetterHelp: Online therapy and counseling. Go to https://betterhelp.com/lex LMNT: Zero-sugar electrolyte drink mix. Go to https://drinkLMNT.com/lex OUTLINE: (00:00) - Introduction (10:19) - Scaling laws (19:25) - Limits of LLM scaling (27:51) - Competition with OpenAI, Google, xAI, Meta (33:14) - Claude (36:50) - Opus 3.5 (41:36) - Sonnet 3.5 (44:56) - Claude 4.0 (49:07) - Criticism of Claude (1:01:54) - AI Safety Levels (1:12:42) - ASL-3 and ASL-4 (1:16:46) - Computer use (1:26:41) - Government regulation of AI (1:45:30) - Hiring a great team (1:54:19) - Post-training (1:59:45) - Constitutional AI (2:05:11) - Machines of Loving Grace (2:24:17) - AGI timeline (2:36:52) - Programming (2:43:52) - Meaning of life (2:49:58) - Amanda Askell - Philosophy (2:52:26) - Programming advice for non-technical people (2:56:15) - Talking to Claude (3:12:47) - Prompt engineering (3:21:21) - Post-training (3:26:00) - Constitutional AI (3:30:53) - System prompts (3:37:00) - Is Claude getting dumber? (3:49:02) - Character training (3:50:01) - Nature of truth (3:54:38) - Optimal rate of failure (4:01:49) - AI consciousness (4:16:20) - AGI (4:24:58) - Chris Olah - Mechanistic Interpretability (4:29:49) - Features, Circuits, Universality (4:47:23) - Superposition (4:58:22) - Monosemanticity (5:05:14) - Scaling Monosemanticity (5:14:02) - Macroscopic behavior of neural networks (5:18:56) - Beauty of neural networks

Can time symmetry in physics, combined with exceptional violations of the 2nd law of thermodynamics, and the “quantum handshake” transactional interpretation of Quantum mechanics, open up main stream physics to the possibility of retro-causation? Could it help to explain the many paradoxes left open in modern physics? and is there experimental evidence for it? Today we have the extraordinary possibility of retro-causation to get our heads around: the apparently impossible phenomenon of events in the present causing changes in the past, or future events having an effect in the present depending on how you want to look at it. Today we'll be approaching this topic via the context of time symmetry in physics. As far back as 1947, French quantum physicist Olivier Costa de Beauregard, began to question the usual interpretation of time in quantum mechanics, intuiting that something was missing from the model for the many paradoxes in Quantum Mechanics to remain unexplained. And then, with others get on board over the years, in the 80's, John G Kramer, agreed that the missing ingredient was found in time symmetry and he proposed a ‘quantum handshake' between the waves passing forward and backward in time at the moment of collapse; in this Transactional Interpretation of quantum mechanics, Kramer claimed he had solved the paradoxes. My guest today has put together this research, a re-interpretation of the 2nd law of thermodynamics based on violations where Entropy exceptionally does not hold, and theorisation about quantum correlates to consciousness to create a new theory of retro-causation, which he thinks can be tested. He is Daniel Sheehan, Author and Professor of Physics at the University of San Diego, specialist in plasma physics, violations of the 2nd Law thermodynamics and Retro-causation. He is the founder the Quantum Retro-causation symposia that met at The University of San Diego. What we discuss: 00:00 Intro. 09:00 Time dilation: the twin paradox. 12:20 Time symmetry: reversible time functions in physics equations. 13:20 Violations of the 2nd Law, the Entropic arrow of time. 18:20 Wheeler's bizarre altered double slit experiment. 23:15 Wheeler's ‘Participatory Universe'. 26:00 The history of retro-causation research. 29:15 Bergmann and Lebowitz ‘Two-State Vector Formalism' theory 1964 31:00 Kramer's “Quantum Handshake” Transactional interpretation of QM. 35:30 Sheehan's theory of retro-causation. 36:45 The assumption of quantum processes acting in the brain. 39:00 Issues with quantum consciousness hypotheses. 42:00 Macroscopic quantum systems. 50:00 Precognitive retro-causation experiments: Graff & Cyrus  51:45 Triple blind experiments - blind ‘even to the universe'. 55:00 Is the subject finding out what actually happened important to the result? 57:00 Emotional charge in the future, influencing the past. 59:00 Are some events in the future already fixed? 01:01:30 Global Consciousness aggregate effects in physical systems. 01:02:30 Time symmetry allows the transmission into the past of important. 01:05:00 Wider science reception of such a paradigm shifting ideas as retro-causation. 01:05:00 Getting over our Second law biology habits. References: Vladislav Capek & Daniel P. Sheehan, “Challenges to The Second Law of Thermodynamics: Theory and Experiment”. Stephen Wolfram, “Computational Foundations for the Second Law of Thermodynamics” John Wheeler - Altered double double slit “Delayed Choice” experiment. Bergmann and Lebowitz ‘Two-State Vector Formalism' theory 1964 John G. Kramer's “Transactional interpretation” of Quantum Mechanics. Dale E Graff, Patricia S. Cyrus, ‘Perceiving the future news: Evidence for retrocausation' Paper Global Consciousness project at Princeton, Roger Nelson. Quotes: “The question is more important than the answer”, author unknown. “Order is a state of mind, not a state of matter” On Entropy, Daniel Sheehan. 

A combination of two checkpoint inhibitors used as neoadjuvant therapy for macroscopic, resectable Stage III melanoma brought a highly statistically significant improvement over the standard of care: surgery followed by checkpoint inhibition (therapeutic lymph node dissection followed by adjuvant therapy with nivolumab, pembrolizumab or, in BRAFmut melanoma, dabrafenib + trametinib). This research was reported from the ASCO 2024 Annual Meeting and highlighted the NADINA trial from the Netherlands. After his session at ASCO, the lead author of NADINA, Christian U. Blank, MD, PhD, from the Netherlands Cancer Institute and Antoni van Leeuwenhook Hospital, Amsterdam, the Netherlands, met up with Oncology Times reporter Peter Goodwin to discuss the findings.

Macroscopic Skin Lesions A thorough skin examination should be performed annually to assess for new or changing macroscopic skin lesions. It is critically important to be able to identify and describe normal and abnormal skin and to note your findings carefully, because a change in an existing skin lesion is the most common sign of skin cancer, including deadly ones like melanoma. In this discussion, we will describe the specific ways in which you document skin lesions, using a vocabulary that other clinicians will understand. After listening to this AudioBrick, you should be able to: Explain the importance of physical examination of the skin. Describe skin lesions, explaining and illustrating each of the following: size, type (eg, vesicle, bulla), color, configuration (eg, annular, targetoid, discoid), arrangement (eg, solitary, grouped, linear, reticular), and distribution and location. You can also check out the original brick on Macroscopic Skin Lesions from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com. You will get 5 days of full access to our Rx360+ program, including Step 1 Qmax, Flash Facts, Express Videos, a digital version of First Aid for the USMLE Step 1, and nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/

今期行星酒馆，邀请到了两位外籍人士 Matt 和 Ling。 他们都曾定居中国，在这里度过大部分成年时光。几年间选择了离开的他们，在过去半年，先后回到中国短暂停留。借着两位朋友的「外宾」视角，我想聊聊重新踏上「故土」时经历的轶事和复杂的心情；也分享他们观察到的、这片土地所上发生的微妙变化。 为了让大家更为舒适地对谈，播客主要用英文录制。访谈的翻译版可在海外《行星酒馆》文字专栏找到。希望未来，我们也可以打破语言的隔阂，用同声传译地方式呈现跨语言的对话。 海外用户可在Patreon支持行星酒馆： https://www.patreon.com/planetspeakeasy 海内用户可在爱发电支持行星酒馆： https://www.afdian.net/a/planetspeakeasy In the 2021/22 academic year, there were a total of 211 American students studying in China. Just five years ago, the number stood at 11,639 — a reduction in scale of over fifty times. The steep decline in the number of U.S. students there is just the tip of the iceberg during this dynamic shift between the world's two superpowers. The departure of foreign companies, a drop of international tourists, and the increasingly polarized discourse about foreigners all contribute to this trend, resulting in an ongoing exodus of expats from a country that once seemed warm to them. Macroscopic consequences aside, there are tangible—and deeply painful—personal costs resulting from this rupture. Many of those in-betweeners were forced to leave behind the lives they had built, the languages they had picked up, the friendships they had forged, the communities they had cultivated, and an entire world they had settled into. On a broader scale, the land has become an increasingly opaque entity to the outside world, as those with firsthand experiences and the patience to navigate its intricacies are becoming growingly marginalized, both physically and culturally. Ironically, the only way to (kind of) start processing what we've lost over these few years is to start talking about our collective loss of understanding. In this inaugural English episode of Planet Speakeasy, two friends who once spent a significant portion of their adult lives in China shared a candid discussion about their recent "homecoming" trip: the familiar, the confusing, the surprising, and the beautiful, chaotic youth in an elusive "home" that we all miss so very much. Support Planet Speakeasy on Patreon: https://www.patreon.com/planetspeakeasy Support Planet Speakeasy on Afdian: https://www.afdian.net/a/planetspeakeasy (02:05)「西安户口」的Matt和疫情中搬家的Ling (03:58) 旅程前的复杂心绪，到刚下飞机的第一印象 (08:37) 微信支付与滴滴，国内方便的不方便 (13:51) 飞盘文化的崛起背后，一些微妙的新现实 (16:41) 失落与悵惘，地方变了还是我们老了？ (20:08) 一个反复被提起的挣扎：“为什么还没出国？” (21:38) 失落的连接背后，中美语境下不同的创作困境 (28:10) 一场酷儿舞会背后的思考 (30:49) 面对断裂，我们还能找到主体性吗？ (40:10) 新冠后，一场百感交集的婚礼 (45:00) 记录这个地方，缺席的情感事实 (47:28) 按摩店里，一场可能不会被记录的对话 (51:59) 差点忘了，疫情间我们都逃进了工作 (57:07) 短视频与直播带货的文化冲击

Bekijk de nieuwe GoudKoorts Gasten aflevering van GoldRepublic met Ab Flipse en Pim van Rijswijk hier: https://youtu.be/L5kFo0nLvrcBekijk de nieuwe Brands & Flipse aflevering van GoldRepublic hier: https://youtu.be/78qdLM4L5Os Bekijk de nieuwe Macroscopic aflevering van GoldRepublic met Arno Wellens hier: https://www.youtube.com/watch?v=kHukiXqYoSw&t=3591s ⚜️ Open een gratis account bij GoldRepublic:

Bekijk de nieuwe Macroscopic aflevering van GoldRepublic met Arno Wellens hier: https://www.youtube.com/watch?v=kHukiXqYoSw&t=3591s

Dear Listeners, We are lucky to have Dr. Kevin back on the podcast. Micro and macroscopic hematurea are common incidental findings in primary care. They are often of a bening nature, but it is important to have a thorough method  in investigating their differential so as not to miss rare but serious causes of bleeding […] The post Podcast 84: Dr. Kevin on Micro and Macroscopic Hematurea appeared first on Primary Medicine Podcast.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.20.521210v1?rss=1 Authors: Bin Khalid, I., Reifenstein, E. T., Auer, N., Kunz, L., Kempter, R. Abstract: Grid cells are neurons in the entorhinal cortex that play a key role in spatial navigation. When subjects navigate through spatial environments, grid cells exhibit firing fields that are arranged in a triangular grid pattern. As direct recordings of grid cells from the human brain are only rarely possible, functional magnetic resonance imaging (fMRI) studies proposed and described an indirect measure of entorhinal grid-cell activity, which is quantified as a hexadirectional modulation of fMRI activity as a function of the subject's movement direction. However, it still remains unclear how the activity of single grid cells is related to the sum activity of a population of grid cells, which may exhibit hexadirectional modulation and thus provide the basis for the hexadirectional modulation of entorhinal cortex activity measured with fMRI. Here, we thus performed numerical simulations and analytical calculations to better understand how the aggregated activity of many grid cells may be hexadirectionally modulated. Our simulations implemented three different hypotheses proposing that the hexadirectional modulation occurs because grid cells show head-direction tuning aligned with the grid axes; are subjected to repetition suppression; or exhibit a bias towards a particular grid phase offset. Our simulations demonstrate that all three hypotheses can, in principle, lead to a hexadirectional modulation of sum grid-cell activity. However, the magnitude of the hexadirectional modulation appears to depend considerably on the subject's navigation pattern and the exact biological properties of grid cells. Our results thus indicate that future fMRI studies could be designed to test which of the three hypotheses most likely accounts for the fMRI measure of grid cells. These findings also underline the importance of quantifying the biological properties of single grid cells in humans to further elucidate how hexadirectional modulations of fMRI activity may emerge. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Do you know what helps coaches to stand out from the crowd and be successful? In this episode, I'll be discussing the importance of putting on macroscopic glasses and how they can help you see the big picture and set you apart from the competition. I touch on why coaches should always look outside of the box and focus on developing their own unique style and approach. I also share what I've learned from many different marketing strategies over the years and how it has helped me to create an extraordinary business. Tune in and pay close attention to my advice on how to discover what other industries are doing! Key Highlights: [00:01 - 02:02] How to Stand Out from the Crowd • An overview of how to stand out from the crowd and be successful • Why you need to see the big picture [02:03 - 04:07] How to Successfully Market Yourself as a Coach • Don't limit yourself based on what the coaches before you have done • You have to look outside of the box and see what other industries are doing • The ideas you can get from looking at other industries and businesses [04:08 - 05:50] Wrapping Up! • Keep an eye out for marketing techniques in different industries • Read books on marketing to increase your knowledge Key Quotes: "Marketing strategies that people are using outside the coaching industry work. So you need to start opening your eyes, looking outside the industry and bringing that information to your business." - Terri Levine Let me help you grow your coaching business: Grab this free training and see my revolutionary process in action! Join me and my Inner Circle Students for a behind-the-scenes Live Group Coaching Call: www.6figsin6months.com  If you want to join me in one of our connect and collaborate sessions. Go to https://calendly.com/heartrepreneur/mcm-live-connect-and-collaborate-session, and select a date & time! If you liked my show, please LEAVE A 5-STAR REVIEW, like, and subscribe!

As the Orlando Magic prepare for free agency, their big move is likely done in acquiring Paolo Banchero. Now they look to use their free-agent tools to shore up their roster and continue growing and building their team ahead of the 2023 season.Support Us By Supporting Our Sponsors!PrizePicksCheck out PrizePicks.com and use promo code: “NBA” or go to your app store and download the app today. PrizePicks is daily fantasy made easy!Built BarBuilt Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order.BetOnlineBetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts!Rock AutoAmazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you.Arcade1upPre-order now from arcade1up.com - that's Arcade, the number 1, Up, dot com - for an estimated early September ship date! They are giving away a NBA JAM Shaq edition to a Locked On listener! Enter for a chance to win a game console for your man-cave at arcade1up.com/lockedon.SakaraSakara is a wellness company anchored in food as medicine, on a mission to nourish. Go to Sakara.com/LOCKEDON20 or Enter Code “LOCKEDON20” for 20% off at checkout. Learn more about your ad choices. Visit podcastchoices.com/adchoices

As the Orlando Magic prepare for free agency, their big move is likely done in acquiring Paolo Banchero. Now they look to use their free-agent tools to shore up their roster and continue growing and building their team ahead of the 2023 season. Support Us By Supporting Our Sponsors! PrizePicks Check out PrizePicks.com and use promo code: “NBA” or go to your app store and download the app today. PrizePicks is daily fantasy made easy! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline BetOnline.net has you covered this season with more props, odds and lines than ever before. BetOnline – Where The Game Starts! Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Arcade1up Pre-order now from arcade1up.com - that's Arcade, the number 1, Up, dot com - for an estimated early September ship date! They are giving away a NBA JAM Shaq edition to a Locked On listener! Enter for a chance to win a game console for your man-cave at arcade1up.com/lockedon. Sakara Sakara is a wellness company anchored in food as medicine, on a mission to nourish. Go to Sakara.com/LOCKEDON20 or Enter Code “LOCKEDON20” for 20% off at checkout. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, I review an article on alternatives to Ibuprofen. This episode is sponsored by McNeese Construction. You can also read this episode on our blog at https://yopistudio.blogspot.com/2022/03/natural-alternatives-for-ibuprofen.html To keep this podcast going please feel free to donate at www.paypal.me/yopistudio If you would like to read more on this topic or any other previous topics, you can do so by checking out our blog at https://yopistudio.blogspot.com/ Feel free to see what we are up to by following us at:  https://twitter.com/Dauricee https://parler.com/profile/Daurice/ https://www.facebook.com/yopistudio/ https://www.facebook.com/LouisianaEntertainmentAssociation/ To listen to the podcast, watch creative videos and skits go to https://www.youtube.com/channel/UCvn6tns6wKUwz9xZw11_vAQ/videos Interested in projects Daurice has worked on in the movie industry you can check it out at www.IMDb.com under Daurice Cummings. Please add us to your RSS Feed, & iTunes, iHeart, Spotify, Stitcher, Google Pod, Sound Cloud, and our favorite Podbean! For comments or questions, you can reach us at yopi@post.com To read more about today's topic check out the references below. References: https://www.forbes.com/2004/12/13/cx_mh_1213faceoftheyear.html?sh=7432b7776d57 https://www.reuters.com/article/us-painkillers-risks/high-doses-of-common-painkillers-increase-heart-attack-risks-idUSBRE94S1FV20130529?feedType=RSS&feedName=healthNews https://www.greenmedinfo.com/blog/ibuprofen-kills-more-pain-so-what-alternatives https://www.greenmedinfo.com/blog/ibuprofen-can-stop-your-heart-31-increase-cardiac-arrest-risk https://www.greenmedinfo.com/blog/ibuprofen-deadly-vioxx https://www.greenmedinfo.com/toxic-ingredient/ibuprofen https://www.greenmedinfo.com/substance/arnica https://www.greenmedinfo.com/article/topical-treatment-arnica-effective-ibuprofen-hand-osteoarthritis https://www.greenmedinfo.com/substance/ginger https://www.greenmedinfo.com/article/ginger-effective-mefenamic-acid-and-ibuprofen-relieving-pain-women-primary-dys https://www.greenmedinfo.com/substance/turmeric https://www.greenmedinfo.com/article/efficacy-and-safety-curcuma-domestica-extracts-compared-ibuprofen-patients-kne https://www.greenmedinfo.com/substance/thyme https://www.greenmedinfo.com/article/thymus-vulgaris-least-effective-ibuprofen-reducing-severity-pain-and-spasm-pri https://www.greenmedinfo.com/substance/omega-3-fatty-acids https://www.greenmedinfo.com/article/omega-3-fatty-acids-are-effective-alternative-ibuprofen-reducing-arthritic-pai https://www.greenmedinfo.com/substance/cinnamon https://www.greenmedinfo.com/blog/cinnamon-beats-ibuprofen-pain-study-reveals-2 https://www.greenmedinfo.com/pharmacological-action/anti-inflammatory-agents https://www.greenmedinfo.com/pharmacological-action/analgesics https://www.greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-1 https://www.greenmedinfo.com/toxic-ingredient/non-steroidal-anti-inflammatory-drugs-nsaids Fitzgerald, G.A. 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Retrieved from here.  Tanne, J.H. (2008). Merck used ghostwriters and selective data in Vioxx publications, JAMA says. British Medical Journal, 336(849). doi: link.  Steenhuysen, J. (2009). Vioxx risks could have been detected earlier: study. Reuters. Retrieved from here. Willson, D. (2011). Merck to Pay $950 Million Over Vioxx. The New York Times. Retrieved from here. The Associated Press. (2010). Supreme Court Allows Investors to Sue Merck Over Vioxx. The New York Times. Retrieved from here.  ConsumerAffairs. (2004). The Food and Drug Administration (FDA) estimates that Vioxx may have contributed to 27,785 heart attacks. Retrieved from here.  Kearney et al. (2006). Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drug increase the risk of atherothrombosis? Meta-analysis of randomised trials. British Medical Journal, 332, 1302-1308.  McGettigan, P., & Henry, D. (2011). Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Medicine, 8, e1001098.  Trelle et al. (2011). Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. British Medical Journal, 342, c7086.  Sostres, C., Gargallo, C.J., & Lanas, A. (2013). Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Research Therapies, 15(Suppl 3), S3.   Marlicz et al. (2014). Nonsteroidal anti-inflammatory drugs, proton pump inhibitors, and gastrointestinal injury: contrasting interactions in the stomach and small intestine. Mayo Clinic Proceedings, 89(12), 1699-1709.  Maiden et al. (2005). A quantitative analysis of NSAID-induced small bowel pathology by capsule endoscopy. Gastroenterology, 128(5), 1172-1178. Goldstein et al. (2005). Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole and placebo. Clinical Gastroenterology and Hepatology, 3(2), 133-141.  Shiotani et al. (2010). Randomized, double-blind pilot study of gnarly geranylacetone versus placebo in patients taking low dose enteric-coated aspirin: low-dose aspirin-induced small bowel damage. Scandinavian Journal of Gastroenterology, 45(3), 292-298.  Caunedo-Alvarez et al. (2010). Macroscopic small bowel mucosal injury caused by chronic non steroidal anti-inflammatory drugs (NSAIDs) use as assessed by capsule endoscopy. Rev Esp Enferm Dig, 102(2), 80-85. Kent, T.H., Cardelli, R.M., & Stamler, F.W. (1969). Small intestinal ulcers and intestinal flora in rats given indomethacin. American Journal of Pathology, 54(2), 237-249. Uejima et al. (1996). Role of intestinal bacteria in ileal ulcer formation in rats treated with a non steroidal anti-inflammatory drug. Microbiology and Immunology, 40(8), 553-560.  Watanbe et al. (2008). Non-steroidal anti-inflammatory drug-induced intestinal damage is Toll like 4 receptor dependent. Gut, 57(2), 181-187. Fasano, A. (2012). Leaky gut and autoimmune disease. Clinical Reviews in Allergy and Immunology, 42(1), 71-78.  Lanza, F.L., Chan, F.K., & Quigley, E.M. (2009). Practice parameters committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology, 104(2), 728-238.  Bhatt et al. (2008). ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of anti platelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation, 118(18), 1894-1909.  American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis and Rheumatology, 46(2), 328-346.  Wallace et al. (2011). Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology, 141(4), 1314-1322.   Endo et al. (2011). Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study. Journal of Gastroenterology, 46(7), 894-905.  Bhala et al. (2013). Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. The Lancet, 382(9894), 769-779.  Montenegro et al. (2014). Non steroidal anti-inflammatory drug induced damage on lower gastro-intestinal tract: is there an involvement of microbiota? Current Drug Safety, 9(3), 196-204. Ozgoli, G., Goli, M., & Moattar, F. (2009). Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. Journal of Alternative and Complementary Medicine, 15(2), 129-132. doi: 10.1089/acm.2008.0311. Salmalian et al. (2014). Comparative effect of thymus vulgaris and ibuprofen on primary dysmenorrhea: A triple-blind clinical study. Caspian Journal of Internal Medicine, 5(2), 82-88.  Levy et al. (2009). Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Nutrition Research, 29(5), 298-304. doi: 10.1016/j.nutres.2009.04.003. Conrozier et al. (2014). A Complex of Three Natural Anti-inflammatory Agents Provides Relief of Osteoarthritis Pain. Alternative Therapies in Health and Medicine, 20(Suppl 1), 32-37.  Chiu et al. (2016). Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician, 19(1), E97-E112. Diener et al. (2005). Efficacy and safety of 6.25 mg tid feverfew CO2‐extract (MIG‐99) in migraine prevention—a randomized, double‐blind, multicentre, Placebo‐controlled study. Cephalalgia, 25(11), 1031–1041. Lipton et al. (2004). Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology, 63(12), 2240-2244.  Shara, M., & Stohs, S.J. (2015). Efficacy and Safety of White Willow Bark (Salix alba) Extracts. Physiotherapy Research, 29(8), 1112-1116. doi: 10.1002/ptr.5377. Vlachojannis, J.E., Cameron, M., & Chrubasik, S. (2009). A systematic review on the effectiveness of willow bark for musculoskeletal pain. Phytotherapy Research, 23(7), 897-900. doi: 10.1002/ptr.2747. Wesolowska et al. (2006). Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. Journal of Ethnopharmacology, 107, 254-258. Gupta, S.K., & Ansari, S.H. (2005). Review on phytochemical and pharmacological aspects of Cichorium intybus L. Asian Journal of Chemistry, 17, 33-36. Tall et al. (2004). Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Brain and Behavior Research, 153(1), 181-188. Seeram et al. (2001). Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine, 8(5), 362-369. Kuehl et al. (2010). Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial. Journal of International Society of Sports Nutrition, 7, 17. doi: 10.1186/1550-2783-7-17. Illich, I. (1974). Medical Nemesis: The Expropriation of Health. New York: Pantheon Books. Capone et al. (2004). Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects.          

Today Tiffany and Katja take a look at the cutting-edge new topic of fascia and pain. Pain is complex and recent research is showing just how relevant the fascial tissue is when we're looking at pain. In this episode, Katja shares the findings of the latest research on changes in fascia that can contribute to pain. The pair discuss the difference between pain in the fascia versus pain in muscle tissues and potential causes of fascial pain. They also touch on how other aspects such as the lymphatic system and lifestyle factors relate to inflammation, pain, and the fascial system. Listen in to learn about the anatomy and physiology of fascia and pain, how it happens, and ways you can potentially intervene. Show Notes: Why it's important to differentiate pain in fascia versus muscle [3:37] Unpacking delayed onset muscle soreness pain [8:45] The complexity of pain [9:52] Causes of fascial pain [12:49] Macroscopic changes in fascia that can contribute to pain [13:37] Microscopic changes in fascia that can contribute to pain [17:42] Role of innervation in fascial pain [24:38] Innervation of fascia and low back pain [25:18] How innervation changes with inflammation [28:37] Vascular and lymphatic system and their role in inflammation and pain [31:40] Causes of hypersensitivity to pain [35:28] Changes in the tension of the fascial system as it relates to pain [38:48] How psychology and lifestyle may affect inflammation [47:51] Links Mentioned: Watch this episode on YouTube Yoga Medicine Podcast Episode 14: Fascia as a Sensory Organ Fascia & Pain Resources Doc Yoga Medicine Online Connect with Katja Bartsch: Facebook | Instagram | Kalamana Yoga You can learn more about this episode, and see the full show notes at www.YogaMedicine.com/podcast-19. And you can find out more about insider tips, online classes or information on our teacher trainings at www.YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.

Veda Austin shares about how she works with water as a crystallographer, and the discoveries she has made through her work. You'll also hear about: The messages Veda has received through communication with water Hydroglyphics and why Veda is working with water to develop a universal language of communication Why anyone can practice CMP and conscious water communication The 4th phase of water ♥♥♥ Join The Earth Speak Collective Membership! Join like-hearted folks in a sacred container and community where you'll: Connect deeply to yourself, others, nature & spirit Learn to trust your intuition Activate your Earth magic Expand your healing & divination skills Put your intuition into practice in everyday life Stop feeling lonely on your spiritual path Embody & express your creative power & truths Experience safe space without agenda or judgment When you join the Collective, you get access to all of our past workshops, any live workshops happening while you're a member, live weekly energetic reset calls, monthly community rituals, all the secret episodes, member-run meetups to explore magical topics, and a lively members-only forum (that's not on FB!). ▶▶▶ Learn more and sign up for the Collective membership here: https://www.earthspeak.love/collective ***** Veda Austin is a water researcher, public speaker, mother, artist, and author. She has dedicated the last 8 years observing and photographing the life of water. She believes that water is fluid intelligence, observing itself through every living organism on the planet and in the Universe.  Her primary area of focus is photographing water in its ‘state of creation', the space between liquid and ice. It is through her remarkable crystallographic photos that water reveals its awareness of not only Creation, but thought and intention through imagery. Learn more about Veda's work at vedaaustin.com. We are excited to share that Veda will be leading a workshop with us, on Interrupting the Wisdom of Water. In this workshop, you will learn a special technique to interact with the ancient intelligence of water through crystallization.    In this episode, we talk about: How the work of Masaru Emoto has influenced Veda Water as a living being and spiritual teacher The importance of inviting the Spirit of water into research and investigation Emojis as the modern hieroglyphs What messages Veda has received through communication with water How Veda discovered that water stores and shares information through imagery The 4th phase of water How Veda developed the technique of CMP to communicate with water Hydroglyphics and the universal language of water Connecting to the energy of plant medicine, through conscious water communication Healing unwell water A message about death, from the Spirit of water On being a researcher outside the realms of conventional science How to change your everyday relationship with water What happened what water was treated like a lab-rat The origins of water on Earth Relating to the world through the lens of animism Nature Spirits and why connecting with nature is so important On sending your consciousness into the unseen places of nature How the water we drink has been through the clouds and the trees and our ancestors On what happened when Veda froze her tears How Veda connected with her mother through water Recording your dreams with water Water as both an observer and an active participant Urine as an offering to the Earth The implications of consciously and unconsciously directing energy How the health of the water reflects the health of the people The story of how the Spirit of water connected Veda to her partner And more! Secret Episodes! Get access to past secret episodes at https://www.earthspeak.love/secret. Links: Join the Earth Speak Collective Membership at https://www.earthspeak.love/collective  Learn more and connect with Jasper Joy @queerconjuer // http://www.instagram.com/queerconjuer    Learn more about Veda's offerings at www.vedaaustin.com  Connect with Veda on Instagram @vedaaustin_water // https://www.instagram.com/vedaaustin_water/   Connect with Veda on Facebook @waterresearcher //  Purchase a one-time pass to the live Interpreting the Wisdom of Water Workshop https://www.earthspeak.love/workshops?loxi_pathname=%2Finterpreting-wisdom-of-water-3112   Or join the Collective to access all past and future workshops at https://www.earthspeak.love/collective  Get the secret episodes at https://www.earthspeak.love/secret  References: Native Land https://native-land.ca/ Kat Lee https://www.empoweredcuriosity.com/ Kat Lee || Episode 67 https://www.earthspeak.love/shows-1/kat-lee-67   Veda workshop https://www.earthspeak.love/interpreting-the-wisdom-of-water Connect with Jasper Joy at http://www.instagram.com/queerconjuer    Olaf the Black https://en.wikipedia.org/wiki/Olaf_the_Black Masaru Emoto https://en.wikipedia.org/wiki/Masaru_Emoto Journey into the Heart of Water || Book http://waterphoto.eu/en/livre/ Māori https://en.wikipedia.org/wiki/M%C4%81ori_people Petri dish https://en.wikipedia.org/wiki/Petri_dish   Geometry https://en.wikipedia.org/wiki/Geometry Emoji https://en.wikipedia.org/wiki/Emoji Hieroglyphs https://en.wikipedia.org/wiki/Hieroglyph Thomas Galen Hieronymus https://en.wikipedia.org/wiki/Hieronymus_machine Gerald Pollack https://www.pollacklab.org/ Stairway to Heaven|| Song https://en.wikipedia.org/wiki/Stairway_to_Heaven Origins of water on Earth https://en.wikipedia.org/wiki/Origin_of_water_on_Earth Crystallography https://en.wikipedia.org/wiki/Crystallography Veda's Facebook group https://www.facebook.com/groups/secretintelligenceofwater Rupert Sheldrake https://en.wikipedia.org/wiki/Rupert_Sheldrake DMT https://en.wikipedia.org/wiki/N,N-Dimethyltryptamine Ayahuasca https://en.wikipedia.org/wiki/Ayahuasca Ibogaine https://en.wikipedia.org/wiki/Ibogaine Hexagon https://en.wikipedia.org/wiki/Hexagon Ashram https://en.wikipedia.org/wiki/Ashram Sari https://en.wikipedia.org/wiki/Sari Tulip https://en.wikipedia.org/wiki/Tulip Afghan dog https://en.wikipedia.org/wiki/Afghan_Hound Charlottes Web || Book https://en.wikipedia.org/wiki/Charlotte%27s_Web Lotus https://en.wikipedia.org/wiki/Nelumbo_nucifera Bulrush https://en.wikipedia.org/wiki/Typha Magical Egypt || Series https://www.magicalegypt.com/ Pseudoscience https://en.wikipedia.org/wiki/Pseudoscience Animism https://en.wikipedia.org/wiki/Animism 5G https://en.wikipedia.org/wiki/5G Tesla https://en.wikipedia.org/wiki/Tesla,_Inc. Viktor Schauberger https://en.wikipedia.org/wiki/Viktor_Schauberger Trout https://en.wikipedia.org/wiki/Trout The Secret Intelligence of Water || Book  https://www.vedaaustin.com/copy-of-buy-the-digital-book Bruce lee https://en.wikipedia.org/wiki/Bruce_Lee Macroscopic https://en.wikipedia.org/wiki/Macroscopic_scale Roti https://en.wikipedia.org/wiki/Roti Shop Veda's techniques and more https://www.vedaaustin.com/shop     ► Leave us a written review on iTunes, and get shouted out on the show! Theme music is “It's Easier” by Scarlet Crow http://www.scarletcrow.org/ and “Meeting Again” by Emily Sprague  https://mlesprg.info/ ► Join the Earth Speak Collective Membership at https://www.earthspeak.love/collective Follow Earth Speak on Instagram and tag us when you share @earthspeak https://www.instagram.com/earthspeak

Today my guest is Macroscopic Technician Hatice Beseren What we discuss with Hatice: Her training to become a macroscopic technician How cytology in integrated into her job duties Her role in remote frozen sections Standardization and certification efforts in Turkey The use of Twitter for education Her role in teaching  Her efforts to form an association of macroscopic technicians Links for this episode: Health Podcast Network  LabVine Learning The ConfLab from LabVine Dress A Med scrubs   Hatice Beseren on Twitter Macroscopists and Cytotechnicians - The Pathologists Counterpart Hatice Beseren on the 2020 Pathologist Power List   People of Pathology Podcast: Website Twitter

Kyle Cheveldayoff joins us to chat about making the change, and building a village in Costa Rica. We chat about making the major changes, intentional communities, incorporating the Law of One, the Macroscopic level, how the universe works, and building community.   We also chat about seeking power of love and not love of power, the Schumann resonance, permaculture, and his journey to awakening of the lies perpetrated in our own Canadian Media.   Brady joins us for this one too and asks some questions on the Law of One.     Spiritual Evolution A Canadian group united in the wake of corrupt Media, Gov't, & Big Tech agendas. Relocating to Costa Rica in mid 2021 to disseminate information the main stream media censors and share our journey into a New Paradigm of consciousness and community living. https://t.me/SpiritualEvolutionChannel   Law of One Study Channel This is a Channel dedicated to topics related to the Law of One (llresearch.org) https://t.me/LawofOneChannel   Thank you for your support.  To gain access to the second half of show and our Plus feed please clink the link http://www.grimericaoutlawed.ca/support. Help support the show because without your help we can't continue to address these controversial topics. If you value this content with 0 ads, 0 sponsorships, 0 breaks, 0 portals and links to corporate websites, please assist. Many hours of unlimited content for free. Thanks for listening!!   Support the show directly: https://www.patreon.com/grimericaoutlawed   Get your Magic Mushrooms delivered from: Mushroom Spores, Spore Syringes, Best Spore Syringes,Grow Mushrooms   Spores Lab   Get Psychedelics online   Our audio book page: www.adultbrain.ca Darren's book www.acanadianshame.ca   Other affiliated shows: https://www.13questionspodcast.com/ Our New Podcast - 13 Questions www.grimerica.ca The OG Grimerica Show www.Rokfin.com/Grimerica Our channel on free speech Rokfin   Join the chat / hangout with a bunch of fellow Grimerican's  www.grimerica.ca/chats   1-403-702-6083 Call and leave a voice mail or send us a text   GrimericaFM https://s2.radio.co/s053ed3122/listen Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com   Leave a review on iTunes and/or Stitcher: https://itunes.apple.com/ca/podcast/grimerica-outlawed http://www.stitcher.com/podcast/grimerica-outlawed   Sign up for our newsletter http://www.grimerica.ca/news   SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/    Tweet Darren https://twitter.com/Grimerica   Connect through other platforms: https://www.reddit.com/r/grimerica/  https://gab.ai/Grimerica    Purchase swag, with partial proceeds donated to the show www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ ART Napolean Duheme's site http://www.lostbreadcomic.com/  MUSIC Tru North Felix's Site sirfelix.bandcamp.com  

Rich Stone, former international news editor at Science and current senior science editor at the Howard Hughes Medical Institute's Tangled Bank Studios, joins host Sarah Crespi to talk about concerning levels of fission reactions deep in an inaccessible area of the site of the 1986 Chernobyl nuclear disaster. Though nothing is likely to come of it anytime soon, scientists must decide what—if anything—they should do tamp down reactions in this hard-to-reach place. Also on this week's show, Shlomi Kotler, an assistant professor in the department of applied physics at the Hebrew University of Jerusalem, joins Sarah to discuss the quantum entanglement of macroscopic objects. This hallmark of quantum physics has been confined—up until now—to microscopic items like atoms, ions, and photons. But what does it mean that two drums, each the width of a human hair, can be entangled? Read a related insight. This week's episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: Caption: New Safe Confinement structure built over Chernobyl ruins; Credit: URBEX Hungary/Flickr; Music: Jeffrey Cook] Authors: Rich Stone; Sarah Crespi See omnystudio.com/listener for privacy information.

Rich Stone, former international news editor at Science and current senior science editor at the Howard Hughes Medical Institute's Tangled Bank Studios, joins host Sarah Crespi to talk about concerning levels of fission reactions deep in an inaccessible area of the site of the 1986 Chernobyl nuclear disaster. Though nothing is likely to come of it anytime soon, scientists must decide what—if anything—they should do tamp down reactions in this hard-to-reach place. Also on this week's show, Shlomi Kotler, an assistant professor in the department of applied physics at the Hebrew University of Jerusalem, joins Sarah to discuss the quantum entanglement of macroscopic objects. This hallmark of quantum physics has been confined—up until now—to microscopic items like atoms, ions, and photons. But what does it mean that two drums, each the width of a human hair, can be entangled? Read a related insight. This week's episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: Caption: New Safe Confinement structure built over Chernobyl ruins; Credit: URBEX Hungary/Flickr; Music: Jeffrey Cook] Authors: Rich Stone; Sarah Crespi See omnystudio.com/listener for privacy information.

Rich Stone, former international news editor at Science and current senior science editor at the Howard Hughes Medical Institute’s Tangled Bank Studios, joins host Sarah Crespi to talk about concerning levels of fission reactions deep in an inaccessible area of the site of the 1986 Chernobyl nuclear disaster. Though nothing is likely to come of it anytime soon, scientists must decide what—if anything—they should do tamp down reactions in this hard-to-reach place. Also on this week’s show, Shlomi Kotler, an assistant professor in the department of applied physics at the Hebrew University of Jerusalem, joins Sarah to discuss the quantum entanglement of macroscopic objects. This hallmark of quantum physics has been confined—up until now—to microscopic items like atoms, ions, and photons. But what does it mean that two drums, each the width of a human hair, can be entangled? Read a related insight. This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF).

Macroscopic Skin Lesions A thorough skin examination should be performed annually to assess for new or changing macroscopic skin lesions. It is critically important to be able to identify and describe normal and abnormal skin and to note your findings carefully, because a change in an existing skin lesion is the most common sign of skin cancer, including deadly ones like melanoma. In this discussion, we will describe the specific ways in which you document skin lesions, using a vocabulary that other clinicians will understand. After listening to this AudioBrick, you should be able to: Explain the importance of physical examination of the skin. Describe skin lesions, explaining and illustrating each of the following: size, type (eg, vesicle, bulla), color, configuration (eg, annular, targetoid, discoid), arrangement (eg, solitary, grouped, linear, reticular), and distribution and location. You can also check out the original brick on Macroscopic Skin Lesions from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com. You will get 5 days of full access to our Rx360+ program, including Step 1 Qmax, Flash Facts, Express Videos, a digital version of First Aid for the USMLE Step 1, and nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/

Physics is both Classical and Quantum. Classical Physics involves studies of Macroscopic objects and very low speeds. Planets, Asteroids, Stars etc. On the other hand, Quantum Physics go deeper and smaller, with speeds approaching the one of light. We speak of particles, atoms and sub-atomic particles. And this is what we're studying today.

References1.Nozaki T, Nimura A, Fujishiro H, Mochizuki T, Yamaguchi K, Kato R, et al. The anatomic relationship between the morphology of the greater tubercle of the humerus and the insertion of the infraspinatus tendon. J Shoulder Elbow Surg. 2015;24(4):555-60.2.Mochizuki T, Sugaya H, Uomizu M, Maeda K, Matsuki K, Sekiya I, et al. Humeral insertion of the supraspinatus and infraspinatus. New anatomical findings regarding the footprint of the rotator cuff. Surgical technique. J Bone Joint Surg Am. 2009;91 Suppl 2 Pt 1:1-7.3.Chang EY, Chung CB. Current concepts on imaging diagnosis of rotator cuff disease. Semin Musculoskelet Radiol. 2014;18(4):412-24.4.Asghar A GS, Narayan RK. Revisiting the Anatomy of Rotator Cuff Relevant to Rotator Cuff Injury. Natl J Clin Anat. 2020;9:1-6.5.Ricci V, Caliskan A, Nalbant E, Ozcakar L. Suspension Bridge of the Shoulder: Sonoanatomy of the Rotator Cable Revisited. PM R. 2020;12(1):101-3.6.Gyftopoulos S, Bencardino J, Nevsky G, Hall G, Soofi Y, Desai P, et al. Rotator cable: MRI study of its appearance in the intact rotator cuff with anatomic and histologic correlation. AJR Am J Roentgenol. 2013;200(5):1101-5.7.Morag Y, Jamadar DA, Boon TA, Bedi A, Caoili EM, Jacobson JA. Ultrasound of the rotator cable: prevalence and morphology in asymptomatic shoulders. AJR Am J Roentgenol. 2012;198(1):W27-30.8.Rahu M, Kolts I, Poldoja E, Kask K. Rotator cuff tendon connections with the rotator cable. Knee Surg Sports Traumatol Arthrosc. 2017;25(7):2047-50.9.Podgorski MT, Olewnik L, Grzelak P, Polguj M, Topol M. Rotator cable in pathological shoulders: comparison with normal anatomy in a cadaveric study. Anat Sci Int. 2019;94(1):53-7.10.Sheah K, Bredella MA, Warner JJ, Halpern EF, Palmer WE. Transverse thickening along the articular surface of the rotator cuff consistent with the rotator cable: identification with MR arthrography and relevance in rotator cuff evaluation. AJR Am J Roentgenol. 2009;193(3):679-86.11.Yuri T, Kobayashi H, Takano Y, Yoshida S, Naito A, Fujii H, et al. Capsular attachment of the subregions of rotator cuff muscles. Surg Radiol Anat. 2019;41(11):1351-9.12.Huri G, Kaymakoglu M, Garbis N. Rotator cable and rotator interval: anatomy, biomechanics and clinical importance. EFORT Open Rev. 2019;4(2):56-62.13.Adams CR, DeMartino AM, Rego G, Denard PJ, Burkhart SS. The Rotator Cuff and the Superior Capsule: Why We Need Both. Arthroscopy. 2016;32(12):2628-37.14.Bureau NJ, Blain-Pare E, Tetreault P, Rouleau DM, Hagemeister N. Sonographic Visualization of the Rotator Cable in Patients With Symptomatic Full-Thickness Rotator Cuff Tears: Correlation With Tear Size, Muscular Fatty Infiltration and Atrophy, and Functional Outcome. J Ultrasound Med. 2016;35(9):1899-905.15.Burkhart SS, Esch JC, Jolson RS. The rotator crescent and rotator cable: an anatomic description of the shoulder's "suspension bridge". Arthroscopy. 1993;9(6):611-6.16.Cho NS, Moon SC, Hong SJ, Bae SH, Rhee YG. Comparison of Clinical and Radiological Results in the Arthroscopic Repair of Full-Thickness Rotator Cuff Tears With and Without the Anterior Attachment of the Rotator Cable. Am J Sports Med. 2017;45(11):2532-9.17.Arai R, Matsuda S. Macroscopic and microscopic anatomy of the rotator cable in the shoulder. J Orthop Sci. 2020;25(2):229-34.

Marc and Amy collaborated in writing The Bible with and without Jesus, how Jews and Christians interpret the same stories differently. A.J. Levine is Professor of New Testament and Jewish Studies at Vanderbilt Divinity School and University. Marc Zvi Brettler is the Bernice and Morton Lerner Professor of Jewish Studies in the Department of Religious Studies at Duke University. In this Episode we are going learn: What is the Bible for Jew? Who are the Pharisees? What are the Microscopic and Macroscopic lenses to interpret scripture? How have scriptures become weaponized? The Sermon on the Mount, Antithesis or Extensions? and much more! Become a Legend! Get perks for being a supporter of the show by choosing an Emoji! Visit www.patreon.com/christianpodcast SPONSORS: Soundstripe offers Unlimited, royalty free music and sound effects and video for creators. Visit soundstripe.com and enter Promo Code: ChristianPodcast for a 10% Discount in your subscription. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/christianpodcast/message Support this podcast: https://anchor.fm/christianpodcast/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.15.341792v1?rss=1 Authors: Isık, M., Rustenburg, A. S., Rizzi, A., Gunner, M. R., Mobley, D. L., Chodera, J. D. Abstract: The prediction of acid dissociation constants (pKa) is a prerequisite for predicting many other properties of a small molecule, such as its protein-ligand binding affinity, distribution coefficient (logD), membrane permeability, and solubility. The prediction of each of these properties requires knowledge of the relevant protonation states and solution free energy penalties of each state. The SAMPL6 pKa Challenge was the first time that a separate challenge was conducted for evaluating pKa predictions as part of the Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) exercises. This challenge was motivated by significant inaccuracies observed in prior physical property prediction challenges, such as the SAMPL5 logD Challenge, caused by protonation state and pKa prediction issues. The goal of the pKa challenge was to assess the performance of contemporary pKa prediction methods for drug-like molecules. The challenge set was composed of 24 small molecules that resembled fragments of kinase inhibitors, a number of which were multiprotic. Eleven research groups contributed blind predictions for a total of 37 pKa distinct prediction methods. In addition to blinded submissions, four widely used pKa prediction methods were included in the analysis as reference methods. Collecting both microscopic and macroscopic pKa predictions allowed in-depth evaluation of pKa prediction performance. This article highlights deficiencies of typical pKa prediction evaluation approaches when the distinction between microscopic and macroscopic pKas is ignored; in particular, we suggest more stringent evaluation criteria for microscopic and macroscopic pKa predictions guided by the available experimental data. Top-performing submissions for macroscopic pKa predictions achieved RMSE of 0.7-1.0 pKa units and included both quantum chemical and empirical approaches, where the total number of extra or missing macroscopic pKas predicted by these submissions were fewer than 8 for 24 molecules. A large number of submissions had RMSE spanning 1-3 pKa units. Molecules with sulfur-containing heterocycles or iodo and bromo groups were less accurately predicted on average considering all methods evaluated. For a subset of molecules, we utilized experimentally-determined microstates based on NMR to evaluate the dominant tautomer predictions for each macroscopic state. Prediction of dominant tautomers was a major source of error for microscopic pKa predictions, especially errors in charged tautomers. The degree of inaccuracy in pKa predictions observed in this challenge is detrimental to the protein-ligand binding affinity predictions due to errors in dominant protonation state predictions and the calculation of free energy corrections for multiple protonation states. Underestimation of ligand pKa by 1 unit can lead to errors in binding free energy errors up to 1.2 kcal/mol. The SAMPL6 pKa Challenge demonstrated the need for improving pKa prediction methods for drug-like molecules, especially for challenging moieties and multiprotic molecules. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.25.264200v1?rss=1 Authors: Nogueira, I., Winne, J., Lima, T. Z., Malfatti, T. E., Leao, R. N., Leao, K. E. Abstract: Loud noise-exposure generates tinnitus in both humans and animals. Macroscopic studies show that noise exposure affects the auditory cortex; however, cellular mechanisms of tinnitus generation are unclear. Here we compare membrane properties of layer 5 (L5) pyramidal cells (PCs) of the primary auditory cortex (A1) from control and noise-exposed mice. PCs were previously classified in type A or type B based on connectivity and firing properties. Our analysis based on a logistic regression model predicted that afterhyperpolatization and afterdepolarization following the injection of inward and outward current are enough to predict cell type and these features are preserved after noise trauma. One week after a noise-exposure (4-18kHz, 90dB, 1.5 hr, followed by 1.5hr silence) no passive membrane properties of type A or B PCs were altered but principal component analysis showed greater separation between control/noise-exposure recordings for type A neurons. When comparing individual firing properties, noise exposure differentially affected type A and B PC firing frequency in response to depolarizing current steps. Specifically, type A PCs decreased both initial and steady state firing frequency and type B PCs significantly increased steady state firing frequency following noise exposure. These results show that loud noise can cause distinct effects on type A and B L5 auditory cortex PCs one week following noise exposure. As the type A PC electrophysiological profile is correlated to corticofugal L5 neurons, and type B PCs correlate to contralateral projecting PCs these alterations could partially explain the reorganization of the auditory cortex observed in tinnitus patients. Copy rights belong to original authors. Visit the link for more info

In today's episode listeners will be treated to an interesting philosophical discussion. We explore concepts regarding the greater human organism and how it interacts with our energy infrastructure, large corporations, and how the continuum covering Maximum Human Potential to Maximum Human Regret should be applied to all decision making. A review of AC and DC electricity is also presented in conjunction with their use to optimize electrical consumption across the grid. We also explore electrical distribution, storage, and phasing, and load sourcing and shifting and caching options. Enjoy!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.23.217786v1?rss=1 Authors: Mehrkanoon, D. S. Abstract: Synchronous oscillations of neuronal populations support resting-state cortical activity. Recent studies indicate that resting-state functional connectivity is not static, but exhibits complex dynamics. The mechanisms underlying the complex dynamics of cortical activity have not been well characterised. Here, we directly apply singular value decomposition (SVD) in source-reconstructed electroencephalography (EEG) in order to characterise the dynamics of spatiotemporal patterns of resting-state functional connectivity. We found that changes in resting-state functional connectivity were associated with distinct complex topological features, ''Rich-Club organisation'', of the default mode network, salience network, and motor network. Rich-club topology of the salience network revealed greater functional connectivity between ventrolateral prefrontal cortex and anterior insula, whereas Rich-club topologies of the default mode networks revealed bilateral functional connectivity between fronto-parietal and posterior cortices. Spectral analysis of the dynamics underlying Rich-club organisations of these source-space network patterns revealed that resting-state cortical activity exhibit distinct dynamical regimes whose intrinsic expressions contain fast oscillations in the alpha-beta band and with the envelope-signal in the timescale of $

We kick off the series by discussing the psychological basis of Fear of Failure. We deconstruct the barriers preventing us from striving towards the best version of ourselves. We try to inspire the listeners desire for achieving their maximum cognitive capacity.Later in the episode we begin questioning the scale of the universe (Microscopic vs. Macroscopic) and how the unknown resulted in cult/religion formation.Many more topics within! Hit Play and Enjoy !Dr. G (@med.hustle)

[이춘근의 국제정치 135회] ② 세계 정치의 거시분석 (Macroscopic Analysis)

An overview of the entire macroscopic, observable universe, from the cosmic microwave background and galactic superclusters to our local star, the sun. Part 2 will concern the microscopic universe: atoms, subatomic particles, electromagnetic/strong/weak/gravitational forces, relativity, and how structures emerge out of the quantum sea of probabilistic energy fluctuations.

Small Business Celebration, the podcast for successful small businesses by successful small businesses. Today's podcast features David Milazzo of Macroscopic who discuss the importance of listening to your customer, how to control your expansion, and to balance your business personal life.

Though most of the startups that participated in the UCONN Innovation Quest are in the earliest stages of building their business, one returning company, Macroscopic Solutions, is a veteran of the IQ challenge, and returned to offer both advice, and a look at just how far they have come. We sat down with Mark Smith of Macroscopic, who has been a guest on CTStartup as well, to discuss how IQ helped his business grow from an idea into a full-time job with international reach.

Gregory Hutchinson on rhythmic prose and historical themes in Plutarch's 'Lives' and Appian's 'Civil Wars'

Gregory Hutchinson on rhythmic prose and historical themes in Plutarch's 'Lives' and Appian's 'Civil Wars'

Hashim, L (Université d'Orléans) Tuesday 12th April 2016 - 16:00 to 17:00

While quantum theory has been tested to an incredible degree on microscopic scales, quantum effects are seldom observed in our everyday macroscopic world. The curious results of applying quantum mechanics to macroscopic objects are perhaps best illustrated by Erwin Schrödinger's famous thought experiment, where a cat can be put into a superposition state of being both dead and alive. Obviously, these quantum predictions are in stark contradiction to our common experience. Even with plenty of theoretical explanations put forward to explain this discrepancy, a large number of questions about the frontier between the quantum and the classical world remain unanswered. To distinguish between classical and quantum behavior, two fundamental concepts inherent to classical physics have been established over the years: The world view of local realism limits the power of classical experiments to establish correlations over space, while the world view of macroscopic realism (or macrorealism) restricts temporal correlations. Necessary conditions for both world views have been formulated in the form of Bell and Leggett-Garg inequalities, and Bell inequalities have been shown to be violated by quantum mechanics through increasingly conclusive experiments. Furthermore, many challenging steps towards convincing violations of macrorealism have been taken in a number of recent experiments. In the first part of this thesis, conditions for macrorealism are analyzed in detail. Two necessary conditions for macrorealism, the original Leggett-Garg inequality and the recently proposed no-signaling in time condition, are presented. It is then shown that a combination of no-signaling in time conditions is not only necessary but also sufficient for the existence of a macrorealistic description. Finally, an operational formulation of no-signaling in time, in terms of positive-operator valued measurements and Hamiltonians, is derived. In the next part, we argue that these results lead to a suitable definition of classical behavior. In particular, we provide a formalism to judge the classicality of measurements and time evolutions. We then proceed to apply it to a number of exemplary measurement operators and Hamiltonians. Finally, we argue for the importance of spontaneously realized Hamiltonians in our intuition of classical behavior. Next, differences between local realism and macrorealism are analyzed. For this purpose, the probability polytopes for spatially and temporally separated experiments are compared, and a fundamental difference in the power of quantum mechanics to build both types of correlations is discovered. This result shows that Fine's theorem, which states that a set of Bell inequalities is necessary and sufficient for local realism, is not transferable to macrorealism. Thus, (Leggett-Garg) inequalities are in principle not well-suited for tests of macrorealism, as they can never form a necessary and sufficient condition, and unnecessarily restrict the violating parameter space. No-signaling in time is both better suited and more strongly motivated from the underlying physical theory. In the final part of this thesis, a concrete experimental setup for implementing quantum experiments with macroscopic objects is proposed. It consists of a superconducting micro-sphere in the Meißner state, which is levitated by magnetic fields. Through its expelled magnetic field, the sphere's center-of-mass motion couples to a superconducting quantum circuit. Properly tuned, ground state cooling can be realized, since the sphere's motion is extremely well isolated from the surrounding environment. This setup therefore is a promising candidate for the observation of quantum effects in macroscopic systems.

On this week's episode we talk to Mark R Smith and Annette Evans of Macroscopic Solutions. Both Mark and Annette are scientists and they do get deep in this episode. Their passion for creating technology to help further science is apparent and where they are going is fascinating. There are some gems in this episode that showcase how to balance work and personal life as well as how a conversations years before helped guide Mark on founding Macroscopic Solutions. Check out their website where you can buy come prints of some amazing photographs.

Peter Pickl (LMU) gives a talk at the MCMP Colloquium (10 June, 2015) titled "Explaining Macroscopic Systems from Microscopic Principles". Abstract: The revolutionary idea of the late 19th century that the physics of gases can be explained by the dynamics of small, point-like particles had a great influence on physics as well as mathematics and philosophy. This idea has changed our understanding of the physics of macroscopic systems significantly as well as the way we see our universe as a whole. The question of how the connection between the microscopic and the macroscopic world can be explained also arises in other fields, for example the life sciences. Answering this question might have a similar impact on the research in these fields. In the talk I will present recent techniques and results of our research group in deriving macroscopic evolution equations from microscopic principles for certain classical, quantum mechanical and biological systems.

Rainer Hegelmann (Bayreuth) gives a talk at the MCMP Colloquium (15 January, 2014) titled "Understanding epistemic grouping, networking and division of labour: What can simple macroscopic models do?". Abstract: In my talk I’ll start with a minimalistic model of opinion dynamics, the so-called bounded confidence model. Then I present stepwise extensions. In the end we have a model with cognitive division of labor and different epistemic groups, all of them engaged in networking of all sorts. Some of the groups are seeking for the truth or try to climb upwards in cliffy epistemic landscapes. Other groups simply follow the truth seekers and climbers. – As a result we get a simulator that allows, for instance, to analyse cost and benefits of networking and grouping, measured in terms of societal distance to the truth.

Jean Bricmont (Université catholique de Louvain) gives a talk at the 17th UK and European Meeting on the Foundations of Physics (29-31 July, 2013) titled "From the microscopic to the macroscopic world". Abstract: The derivation of the laws describing the macroscopic world from those governing the microscopic one is a very difficult problem. The root of the difficulty is sometimes seen as arising from the fact that the first set of laws are often time-irreversible, while the second ones are time-reversible. The goal of the talk will be to explain precisely these notions (macroscopic, microscopic, (ir)reversibility) and why this difference does not constitute an insuperable difficulty. We will also discuss the role of probability in the derivation of the macroscopic laws from the microscopic ones and criticize several misleading attempts at justifying this derivation.

Harvard Universitet

After myocardial infarction, the implantation of stem cell seeded scaffolds on the ischemic zone represents a promising strategy for restoration of heart function. However, mechanical integrity and functionality of tissue engineered constructs need to be determined prior to implantation. Therefore, in this study a novel pulsatile bioreactor mimicking the myocardial contraction was developed to analyze the behavior of mesenchymal stem cells derived from umbilical cord tissue (UCMSC) colonized on titanium-coated polytetrafluorethylene scaffolds to friction stress. The design of the bioreactor enables a simple handling and defined mechanical forces on three seeded scaffolds at physiological conditions. The compact system made of acrylic glass, Teflon®, silicone, and stainless steel allows the comparison of different media, cells and scaffolds. The bioreactor can be gas sterilized and actuated in a standard incubator. Macroscopic observations and pressure-measurements showed a uniformly sinusoidal pulsation, indicating that the bioreactor performed well. Preliminary experiments to determine the adherence rate and morphology of UCMSC after mechanical loadings showed an almost confluent cellular coating without damage on the cell surface. In summary, the bioreactor is an adequate tool for the mechanical stress of seeded scaffolds and offers dynamic stimuli for pre-conditioning of cardiac tissue engineered constructs in vitro.

Schmeiser, C (Wien) Wednesday 08 September 2010, 10:00-11:00

Fri, 13 Feb 2009 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/9828/ https://edoc.ub.uni-muenchen.de/9828/1/Abel_Benjamin_S.pdf Abel, Benjamin Simon ddc:530, ddc:500, Fakultät für Ph

Background: Between 10,000 and 12,000 cases of imported malaria are notified in the European Union each year. Despite an excellent health care system, fatalities do occur. In case of advanced autolysis, the post-mortem diagnostic is impaired. Quicker diagnosis could be achieved by using rapid diagnostic malaria tests. Methods: In order to evaluate different methods for the post-mortem diagnosis of Plasmodium falciparum malaria in non-immunes, a study was performed on the basis of forensic autopsies of corpses examined at variable intervals after death in five cases of fatal malaria (with an interval of four hours to five days), and in 20 cases of deaths unrelated to malaria. Detection of parasite DNA by PCR and an immunochromatographic test (ICT) based upon the detection of P. falciparum histidine-rich protein 2 (PfHRP2) were compared with the results of microscopic examination of smears from cadaveric blood, histopathological findings, and autopsy results. Results: In all cases of fatal malaria, post-mortem findings were unsuspicious for the final diagnosis, and autoptic investigations, including histopathology, were only performed because of additional information by police officers and neighbours. Macroscopic findings during autopsy were unspecific. Histopathology confirmed sequestration of erythrocytes and pigment in macrophages in most organs in four patients (not evaluable in one patient due to autolysis). Microscopy of cadaveric blood smears revealed remnants of intraerythrocytic parasites, and was compromised or impossible due to autolysis in two cases. PCR and ICT performed with cadaveric blood were positive in all malaria patients and negative in all controls. Conclusion: In non-immune fatalities with unclear anamnesis, ICT can be recommended as a sensitive and specific tool for post-mortem malaria diagnosis, which is easier and faster than microscopy, and also applicable when microscopic examination is impossible due to autolysis. PCR is more expensive and time-consuming, but may be used as confirmatory test. In highly endemic areas where asymptomatic parasitaemia is common, confirmation of the diagnosis of malaria as the cause of death has to rely on histopathological findings.

It is vital not to take our most fundamental physical theories for granted. For example, researchers have looked for deviations from the gravitational inverse square law at very small sub-micron length scales. Similarly, one can ask what predictions of quantum mechanics might break down in untested regimes. Since the classical world is macroscopic and the quantum world is microscopic, a natural place to test quantum mechanics is in mesoscopic physics. Macroscopic superposition is a largely untested mesoscopic prediction of quantum mechanics. An excellent candidate for macroscopic superposition states, also called Cat (or NOON) States after Schrodinger's famous gedanken experiment, is a Bose-Einstein condensate in a double well. Mathematically, this is a fifty year old quantum many body problem. The experimental context of Bose-Einstein condensates gives one hope to observe the first truly large scale Cat States of matter. We show that Bose-Einstein condensates require two new energy scales. We introduce the role of the dimensionality of each well. We demonstrate that the many body wavefunction serves to protect Cat States from decoherence. Finally, we present a practical scheme for dynamic realization of such states. Presented October 12, 2007.

Peace, Ecology and the Human Scale: Leopold Kohr's Idea of Small Societies being Up-to-Date

An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltv phase coexists with the well-known L4 phase of spherical vesicles and a bulk L alpha phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.

Abstract Purple bacterial aggregates found in tidal pools of Great Sippewissett Salt Marsh (Falmouth, Cape Cod, MA) were investigated in order to elucidate the ecological significance of cell aggregation. Purple sulfur bacteria were the dominant microorganisms in the aggregates which also contained diatoms and a high number of small rod-shaped bacteria. Urea in concentrations of ≥ 1 M caused disintegration of the aggregates while proteolytic enzymes, surfactants or chaotropic agents did not exhibit this effect. This suggests that polysaccharides in the embedding slime matrix stabilize the aggregate structure. In addition cell surface hydrophobicity is involved in aggregate formation. The concentration of dissolved oxygen decreased rapidly below the surface of aggregates while sulfide was not detected. The apparent respiration rate in the aggregates was high when the purple sulfur bacteria contained intracellular sulfur globules. In the presence of DCMU, respiration remained light-inhibited. Light inhibition disappeared in the presence of KCN. These results demonstrated that respiration in the aggregates is due mainly to purple sulfur bacteria. The concentration of bacteriochlorophyll (Bchl) a in the aggregates (0.205 mg Bchl a cm−3) was much higher than in the pool sediments but comparable to concentrations in microbial mats of adjacent sand flats. Purple aggregates may therefore originate in the microbial mats rather than in the pools themselves. Rapid sedimentation and high respiration rates of Chromatiaceae in the aggregates would prevent the inhibition of Bchl synthesis if aggregates were lifted off the sediment and up into the oxic pool water by tidal currents.

Tue, 1 Jan 1985 12:00:00 +0100 https://epub.ub.uni-muenchen.de/10300/1/10300.pdf Halberg, F.; Sothern, R.; Arbogast, Helmut