Podcasts about kunz

“We are the swap. 1inch is the swap,” says Sergej Kunz.1inch CEO Sergej Kunz joins David Sencil to discuss 1inch's evolution from a simple DEX aggregator into a full-on marketplace. Kunz shares why 1inch is more than just gas-less swaps and cross-chain liquidity.Timestamps:00:00 Introduction to Oneinch and Its Core Product02:52 Innovation and Expansion in DeFi06:05 Partnerships and Market Dynamics08:47 The Future of DeFi vs. TradFi11:57 Launch on Solana and New Features14:55 Liquidity and Market Fragmentation17:46 Bitcoin Integration and Future OutlookFull interview.

Wort zum Tag von Pfarrerin Susanna Meyer Kunz, Seelsorge Universitätsspital Zürich, ZH

Freude trotz allem. Susanna Meyer-Kunz, leitende Spitalseelsorgerin, Universitätsspital Zürich. Freude ist nicht immer leicht. Ich begleite Menschen, die sich kaum noch freuen können – etwa eine junge Mutter mit Zungenkrebs, deren Therapie ihr jeden Geschmack raubt. Sie sagt: „Alles schmeckt wie Schütte.“ Doch sie findet kleine Lichtblicke – beim Basteln mit ihrer Tochter oder wenn sie die Wohnung putzen konnte. Auch mir geht die Freude abhanden, angesichts von Kriegsbildern oder Zynismus gegenüber Schwächeren. Und doch erinnert mich Paulus im Philipperbrief: „Freut euch im Herrn allezeit.“ Freude ist hier mehr als schneller Spass. Sie ist eine Kraftquelle des Glaubens, die auch im Leid trägt. Darum dürfen wir unsere Bitten laut vor Gott bringen – in Dank, in Tränen, im Schweigen. Ich wünsche uns allen, dass wir in schweren Tagen kleine Freuden entdecken: ein Besuch, ein Lächeln, ein Händedruck. Und dass wir mit dieser Haltung andere anstecken.Danke, wenn Sie unsere Arbeit unterstützen – damit das Wort zum Tag weiterhin täglich gratis gehört werden kann: https://wortzumtag.ch/unterstuetzenFreude, Gebet, Hoffnung, Paulus, Krankheit, Kraftquelle, Nächstenliebe#wortzumtag #freude #gebet #hoffnung #kraftquelle #nächstenliebe #paulus #vertrauen

Himmelsschaukeln – dem Himmel ein Stück näher.Susanna Meyer-Kunz, leitende Spitalseelsorgerin, Universitätsspital Zürich.Kindheitserinnerungen an das Schaukeln – frei, leicht und unbeschwert. Dieses Gefühl hat nun im Universitätsspital Zürich einen festen Platz gefunden: die „Himmelsschaukeln“. Ursprünglich als Projekt gestartet, sind sie inzwischen fest installiert und laden Patientinnen, Angehörige und Mitarbeitende ein, den Alltag für einen Moment loszulassen. Schaukeln beruhigt, schenkt Geborgenheit und bringt Menschen ins Gespräch über Himmel, Hoffnung und das Leben selbst. Für manche wird es zu einer Brücke zurück zum inneren Kind, für andere zu einem stillen Gebet oder einem Stück Himmel mitten im Spital.Spendenaufruf:Hilf mit, dass „Wort zum Tag“ täglich Menschen erreicht – mit deiner Unterstützung: https://wortzumtag.ch/unterstuetzenHimmel, Hoffnung, Geborgenheit, Kindheit, Vertrauen#wortzumtag #hoffnung #geborgenheit #himmel #kindheitserinnerungen #seelsorge #vertrauen #schaukeln #innereRuhe #glaubensimpuls

2 year old DeOrr Kunz Jr. disappeared from a family camping trip in Idaho in 2015. His remains have never been found and there are questionable circumstances surrounding his disappearance, including conflicting statements from those who were with him. What happened to baby DeOrr?www.patreon.com/caffeinatedcrimesInstagram: @caffeinatedcrimespodTwitter: @caffcrimespodEmail: caffeinatedcrimespod@gmail.comFacebook: Caffeinated CrimesSupport the show

Sommaren 2015 försvinner tvåårige Deorr Kunz Junior under en campingtur i Idahos vildmark. På bara några sekunder är han borta och trots massiva sökinsatser med hundar, helikoptrar och dykare hittas aldrig ett enda spår. Inga kläder, inga fotavtryck, inget som förklarar vart han tagit vägen. I detta avsnitt av Universums hemligheter följer vi ett av de mest förbryllande försvinnandena i modern tid.

Kunz, Christopher www.deutschlandfunkkultur.de, Studio 9

Kann Schule Menschen dabei unterstützen und begleiten sich zentralen, individuellen Lebensfragen anzunähern? Wer bin ich? Was kann ich? Was brauche ich? Was will ich? In dieser Folge tauchen wir mit unserem Gast Yvonne Kunz in das Thema „Schulfach Glück" ein. Lernziel: Wohlbefinden. Das zentrale Anliegen von Schulfach Glück ist eine ganzheitliche Persönlichkeitsentwicklung von Kindern, Jugendlichen und jungen Erwachsenen. In dem Verständnis von Yvonne und weiteren begleitenden Personen, ist Persönlichkeitsentwicklung die Grundlage für alle anderen bildungs- und lebensrelevanten Kompetenzen. Wie also kann sich Bildung sich über reproduzierbares Wissen und Angepasstheit erheben und jungen Menschen ermöglichen, ein Bewusstsein für sich selbst und andere herauszubilden? Dies ist die notwendige Voraussetzung für Resilienz und Menschlichkeit, für gelingendes Leben und psychologisches Wohlbefinden und damit auch für Zukunftsfähigkeit. "Lernziel Wohlbefinden - Schulfach Glück" leistet somit einen wesentlichen Beitrag zur Entwicklung der Persönlichkeit von Lernenden und Lehrenden und trägt damit zur Salutogenese bei. Es strebt die Entwicklung von eigenverantwortlichem und selbstständigem Handeln, sowie die Herausbildung eines gesunden Selbstwertgefühls an.

In July of 2015, two-year-old DeOrr Kunz Jr. vanished without a trace during a family camping trip in Idaho. For years, this case has been shrouded in mystery, swirling with unanswered questions, shifting theories, and heartbreaking dead ends, but now, over a decade later, new information has come to light. DeOrr Kunz Jr. was last seen on July 10th, 2015, near Leadore, Idaho, in Lemhi County. He has hazel eyes and, at that time, blonde hair. He was approximately 3 feet tall and weighed about 30lbs. He was last seen wearing cowboy boots, a camouflage jacket, and blue pajama pants. Anyone with information is asked to call the Lemhi County Sheriff's Office at 208-756-8980. For more information about the cases discussed, visit ⁠VoicesforJusticePodcast.com⁠ For even more content or if you just want to support our show, you can join our Patreon at ⁠Patreon.com/voicesforjustice⁠ Follow us on social media: Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@VFJPod⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@VoicesforJusticePodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@VoicesforJusticePodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@VoicesforJusticePodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠   Voices for Justice is hosted by Sarah Turney Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠⁠ YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠@SarahTurney⁠⁠⁠⁠⁠⁠⁠⁠⁠ The introduction music used in Voices for Justice is Thread of Clouds by Blue Dot Sessions. Outro music is Melancholic Ending by Soft and Furious. The track used for ad transitions is Pinky by Blue Dot Sessions. Learn more about your ad choices. Visit podcastchoices.com/adchoices

El tribunal lo declaró culpable de homicidio criminis causa, cuatro tentativas de homicidio y siete privaciones ilegítimas. El hecho ocurrió en agosto de 2022.

Der erste Spieltag ist gespielt! Axel ist voll hyped, Enzo und David sind vorerst noch nicht beunruhigt über ihre Auftakt-Niederlagen, und Basti kann eine Eintracht-Aufstellung, die er sich gebastelt hat, nicht ungesehen machen. Wir philosophieren darüber, ob Bayern ein wirklich großer Club ist, ordnen Barca auf 4B ein und sinnieren darüber, ob wir unbeweglich sind. Außerdem suchen wir erotische Sprachnachrichten im Safe Space, und ein Innerer Enzo läuft durch Bockenheim. Zum Abschluss gibt es ein Tippspiel, das uns volle zwei Stunden beschäftigt. Ihr erfahrt, warum das „Kunz“ geschlossen werden musste, warum thailändische Schneider keinen Wohlgemuth fertigen können und warum man auf Weber-Schulen besondere Ranzen trägt. Außerdem singen wir ein Lied über den Heidelbungert und lernen: Der Niemeyer-Knoten ist der Raaf des Angelns! Viel Spaß! Werde auch DU Funfriend! Den drei90Shop. kennt Ihr ja. Mittlerweile gibt es auch einen drei90 Instagram-Account. Folgt uns auch gerne dort. drei90 via itunes abonnieren drei90 via Feedburner abonnieren

Die gute FrageKaspar Kunz, Pfarrer, Zillis-Schamserberg„Das ist eine gute Frage.“ – so beginnen manchmal Antworten in Interviews. Oft steckt dahinter der Versuch, Zeit zu gewinnen oder sich nicht festlegen zu müssen. Schon Jesus wurde mit Fangfragen konfrontiert – über Steuern, über die Auferstehung, über das wichtigste Gebot. Doch er ließ sich nicht aufs Glatteis führen. Stattdessen gab er eine klare und tiefgründige Antwort: Gott lieben mit ganzem Herzen, ganzer Seele, ganzem Verstand und ganzer Kraft – und den Nächsten wie sich selbst. Gute Fragen entstehen aus ehrlichem Interesse und Respekt, nicht aus dem Wunsch, andere bloßzustellen oder bestätigt zu werden. Jesus lädt uns ein, von ihm zu lernen – auch, wie man echte, offene und hilfreiche Fragen stellt, die Beziehungen vertiefen statt zerstören.Spendenaufruf:

In July of 2015, two-year-old DeOrr Kunz Jr. vanished without a trace during a family camping trip in Idaho. For years, this case has been shrouded in mystery, swirling with unanswered questions, shifting theories, and heartbreaking dead ends, but now, over a decade later, new information has come to light. DeOrr Kunz Jr. was last seen on July 10th, 2015, near Leadore, Idaho, in Lemhi County. He has hazel eyes and, at that time, blonde hair. He was approximately 3 feet tall and weighed about 30lbs. He was last seen wearing cowboy boots, a camouflage jacket, and blue pajama pants. Anyone with information is asked to call the Lemhi County Sheriff's Office at 208-756-8980. For more information about the cases discussed, visit VoicesforJusticePodcast.com For even more content or if you just want to support our show, you can join our Patreon at Patreon.com/voicesforjustice Follow us on social media: Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠@VFJPod⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠@VoicesforJusticePodcast⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠@VoicesforJusticePodcast⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠@VoicesforJusticePodcast⁠⁠⁠⁠⁠⁠⁠⁠   Voices for Justice is hosted by Sarah Turney Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠ TikTok: ⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠@SarahETurney⁠⁠⁠⁠⁠⁠⁠⁠ YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠@SarahTurney⁠⁠⁠⁠⁠⁠⁠⁠ The introduction music used in Voices for Justice is Thread of Clouds by Blue Dot Sessions. Outro music is Melancholic Ending by Soft and Furious. The track used for ad transitions is Pinky by Blue Dot Sessions. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In der neuen Folge von Poddes mit Ketchup geht's wieder rund!

Stairway to HeavenAutor: Kaspar Kunz, Pfarrer, Zillis-SchamserbergBeim Zügeln fand ich eine Kinderzeichnung von mir: Jakob mit dem Kopf auf einem Stein, darüber die Himmelsleiter mit Engeln und hellen Sternen. Ein Bild voller Hoffnung. Denn wie Jakob fragen auch wir: Wie geht es weiter? Was mache ich mit einer Krankheitsdiagnose, einer Operation, einer Krise, die mich überrollt? Solche Nächte rauben uns den Schlaf. Doch Jakobs Traum erinnert uns daran, dass Licht ins Dunkel kommt – auch heute. Gott schenkt neue Wege, Zuspruch und Segen, gerade dann, wenn wir sie am nötigsten haben. Möge sein Licht auch deine dunklen Nächte erhellen und dir Mut und Hoffnung schenken.Spendenaufruf:Unterstütze das „Wort zum Tag“, damit wir weiterhin täglich Hoffnung und Inspiration teilen können: https://wortzumtag.ch/unterstuetzenHoffnung, Licht, Vertrauen, Glaube, Segen, TrostHashtags:#wortzumtag #hoffnung #vertrauen #glaube #lichtindenächten #trost #inspiration #segen #mut #glaubensimpuls #stairwaytoheaven

Der Klimawandel, das Patriarchat, die Überidentifikation mit der eigenen Arbeit: In vielen ihrer Texte geht Nina Kunz Themen nach, die ein Unbehagen in ihr auslösen. Sie zu schreiben, sei wie das Lösen eines schwierigen Kreuzworträtsels. Sich selbst als Autorin zu bezeichnen, war für Nina Kunz ein langer Prozess. Obwohl sie bereits seit ihren frühen Zwanzigern ihr Geld mit dem Schreiben verdient – unter anderem als Kolumnistin für «Das Magazin» – brauchte es einen Bestseller, bis sie sich traute, sich selbst diese Bezeichnung anzuheften: «Ich denk, ich denk zu viel» ist im März 2021 bei «Kein & Aber» erschienen und besteht aus einer Sammlung von dreissig Texten, in denen Kunz sich mit ihrem eigenen Erleben, ihren Gedanken, sowie jeder Menge Sekundärliteratur auseinandersetzt, von Jean-Paul Sartre über Roxanne Gay bis zum US-amerikanischen Linguisten William Labov. Aufgewachsen ist Nina Kunz mitten in der Stadt Zürich, im Kreis 4. In «Musik für einen Gast» erinnert sie sich daran, wie sie als Kind auf einer Pingpongtischplatte sass und sich die Scherben aus den Fusssohlen zog, wie sie mit ihren Freundinnen Choreografien zu «Tic Tac Toe» einstudierte und wie sie als Jugendliche die «Bar Italia» in London besuchte; ein Ort, der die englische Rockband «Pulp» zu einem Stück inspiriert hat. Und sie spricht über eines der Themen, das sie so sehr beschäftigt, wie kaum ein anderes: die Auswirkungen des Klimawandels, die sich mittlerweile direkt vor ihrer Haustür zeigen. Die gespielten Titel: 1. Tic Tac Toe - Ich find dich Scheisse 2. Ariana Grande - Thank U, Next 3. Pulp - Bar Italia 4. Sharon Van Etten - The End of the World 5. Stereo Luchs - Ziitreis Erstsendung: 21.01. 2024

Wort zum Tag - Pfarrer Kaspar Kunz, Zillis Schamserberg GR

In dieser Episode von SEOpresso diskutieren Björn Darko und Christian Kunz das Content Dilemma im Kontext von SEO, Google und KI. Sie beleuchten die Herausforderungen, vor denen Publisher stehen, und erörtern Strategien zur Anpassung an die sich verändernde Landschaft des Content Marketings. Die Bedeutung von Markenbildung und Direct Traffic wird hervorgehoben, während die Notwendigkeit von Mischstrategien aus kostenlosem und kostenpflichtigem Content betont wird. In dieser Diskussion wird die Transformation der Content-Erstellung durch KI beleuchtet. Die Gesprächspartner erörtern die Herausforderungen und Chancen, die sich aus der Nutzung von KI ergeben, insbesondere in Bezug auf die Qualität der Inhalte und die Notwendigkeit, redaktionelle Standards aufrechtzuerhalten. Zudem wird die Bedeutung von Social Media und anderen Traffic-Quellen hervorgehoben, während Strategien zur Sicherstellung einer nachhaltigen Sichtbarkeit in einer sich verändernden digitalen Landschaft diskutiert werden.TakeawaysSEO ist spannender denn je, trotz Unsicherheiten.Publisher müssen sich an die Veränderungen anpassen.Content-Erstellung bleibt wichtig, aber die Monetarisierung ist herausfordernd.KI kann Inhalte zusammenfassen, was Publisher unter Druck setzt.Bezahlschranken sind nicht immer eine Lösung für Publisher.Direct Traffic wird immer wichtiger für die Sichtbarkeit.Markenbildung ist entscheidend in der neuen Content-Landschaft.Mischstrategien aus kostenlosem und kostenpflichtigem Content sind notwendig.Vertrauen in Marken wird für die Nutzer wichtiger.Die Suche als Traffic-Quelle wird an Bedeutung verlieren. Der Übergang zu KI-gestütztem Content erfordert eine sanfte Anpassung.Hochwertige redaktionelle Inhalte bleiben auch in Zukunft wichtig.KI kann viele Fleißarbeiten in der Content-Erstellung übernehmen.Die Qualität der Inhalte muss durch redaktionelle Prüfungen sichergestellt werden.Podcasts bieten Potenzial für Markenwahrnehmung und Traffic.Social Media wird zunehmend wichtiger für Referral-Traffic.Die Traffic-Zusammensetzung kann aktiv gestaltet werden.SEO bleibt ein zentraler Bestandteil der digitalen Strategie.Klassische Marketingmethoden sollten nicht vernachlässigt werden.Die Balance zwischen KI und menschlicher Expertise ist entscheidend.Chapters00:00 Einführung in das Content Dilemma02:02 Die Herausforderungen für Publisher06:00 Zukunftsstrategien für Content-Anbieter09:50 Die Rolle von Marken und Direct Traffic14:09 Mischstrategien für Content und Traffic19:22 Der Übergang zu KI-gestütztem Content20:21 Die Herausforderung der Content-Qualität23:17 Die Rolle von KI in der Content-Erstellung27:47 Zukünftige Traffic-Quellen und Social Media34:51 Strategien für nachhaltigen Traffic41:03 Die Balance zwischen KI und klassischem Content

In this mailbag episode, Dave answers a variety of "Ask Dave" questions sent in by DCS listeners like you. From questions on top food vacation spots to his favorite 'Chef's Table' episode, Dave has plenty of recommendations to share. He also answers questions about lessons he wants to pass along to his kids, as well as kitchen topics like what chefs like to collect, hand washing, and more. Keep sending in "Ask Dave" questions to bit.ly/AskDaveForm or askdave@majordomomedia.com to get your answers on the podcast AND be entered for a prize. A winner for the first prize will be coming soon... Learn more about Netflix Chef's Table: https://www.netflix.com/title/80007945?source=35&fromWatch=true  Learn more about Noma: https://noma.dk/  Learn more about Netflix Chef's Table: Pizza: https://www.netflix.com/title/81292981  Learn more about Pizzeria Bianco: https://www.pizzeriabianco.com/los-angeles  Learn more about the Kunz spoon: https://www.jbprince.com/products/gray-kunz-sauce-spoon?srsltid=AfmBOopD4Vuw4odXWrEsQkDmCxRpzNHpMbRTx0vPmI1JV0MAP0xqv9l-  Learn more about Bernaurdaud ceramics: https://www.bernardaud.com/en/us?srsltid=AfmBOoqNEAkz9ynVE4fvG0GhGEDVDUZRIup3164wvO26BIPa2f6ZPQwg  Learn more about Central: https://centralrestaurante.com.pe/en/  Learn more about Per Se: https://thomaskeller.com/perseny/  Learn more about Arpege: https://www.alain-passard.com/en/  Watch the “As the Meat Turns” episode of Ugly Delicious: https://www.netflix.com/title/80170368  Learn more about Alinea: https://www.thealineagroup.com/  Listen to our seafood episode with Ari Kolender of Found Oyster: https://open.spotify.com/episode/2Onz2RWEFBNpNI8A3t50mE?si=7PsWHbdWSOq9egTdkqnCOA  Learn more about Tommy's Burger: https://originaltommys.com/  Watch our episode with Chef Edward Lee: https://youtu.be/lMsRnrrYL_M  Watch our episode with Chef Roy Choi: https://youtu.be/C0QSNhSQfkY  Learn more about Musso & Frank: https://mussoandfrank.com/  Learn more about Stretch pizza: https://www.stretchpizzanyc.com/  Learn more about Athletic: https://athleticbrewing.com/  Learn more about Gymkhana: https://gymkhanalondon.com/  Learn more about The Next Thing You Eat: https://press.hulu.com/shows/the-next-thing-you-eat/  Learn more about Nobu: https://noburestaurants.com/  Send in your Ask Dave questions to bit.ly/AskDaveForm or askdave@majordomomedia.com. Subscribe to the show on YouTube: https://www.youtube.com/@thedavechangshow. Subscribe to Recipe Club on YouTube: https://www.youtube.com/@recipeclubofficial. Submit your favorite food moments in your favorite movies to majorfoodporn.com. Join our community Discord on majordomo.com. Host: Dave Chang Majordomo Media Producer: David Meyer Spotify Producer: Felipe Guilhermino Editor: Stefano Sanchez Learn more about your ad choices. Visit podcastchoices.com/adchoices

Hey ihr Kartenhaie, Lichtgestalten und Zukunftsunternehmer!

July 10th, 2015. Timber Creek campground, near Leadore, Idaho. Two-year-old DeOrr Kunz Jr disappeared while on a camping trip with family. Nearly 10 years later, he has not been found. For bonus episodes and outtakes visit: patreon.com/generationwhyListen ad free with Wondery+. Join Wondery+ for exclusives, binges, early access, and ad free listening. Available in the Wondery App. https://wondery.app.link/generationwhySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Wort zum Tag von Pfarrerin Sandra Kunz, Kirchgemeinde Trubschachen, BE

DeOrr Kunz Jr, de dois anos, desapareceu em 2015 que foi acampar com os pais. Enquanto os pais achavam que seu bisavô estava tomando conta, o bisavô achou que o menino foi com os pais pescar. Então o menino desapareceu sem deixar qualquer rastro. ❤ Torne-se um apoiador pelo Apoia.se ou pela Orelo❤ Segue a gente no ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠ Pesquisa e roteiro: Marcela Souza Edição: Alexandre LimaSee omnystudio.com/listener for privacy information.

Wort zum Tag von Pfarrerin Sandra Kunz, Kirchgemeinde Trubschachen, BE

Esta semana se viralizó un reel protagonizado por Pablo Vázquez Kunz, donde se afirma que “desde la biodescodificación no existe el contagio” y que “una persona que tiene una enfermedad denominada de transmisión sexual, en realidad no es de transmisión sexual, es un programa biológico activo”. Este tipo de contenido pone en riesgo a la población, especialmente a adolescentes y jóvenes, quienes hoy consumen información sobre salud sexual principalmente desde redes sociales. Si la desinformación se vuelve tendencia, tenemos un problema colectivo. Y si a esto se le suma la falta de implementación integral de la Ley de Educación Sexual Integral, el desmantelamiento de políticas públicas de prevención y el desabastecimiento de métodos de barrera, entonces el daño no es simbólico: es un hecho.Todos los miércoles, a las 8.20 am les espero en mi columna para hablar de sexualidad, vínculos y sexoafectividad en @notifyok, por @gambaonline @soniderafm Pueden encontrarme en Instagram como @lic.noeliabenedetto ⁠⁠⁠https://www.instagram.com/p/Cfq_p9jLuqy/?igshid=YmMyMTA2M2Y=

Liebe Hörerinnen, liebe Hörer. Heute gibt es eine neue Folge meines Podcasts. Als Gast war Andi Kunz, früherer Handball-Bundesliga-Spieler, Spielertrainer, Trainer und Geschäftsführer und Inhaber des Medizinischen Trainingszentrum in Großwallstadt, MTZ, bei mir zu Besuch. Andi hat jüngst seinen Trainerposten beim Drittligisten TV Kirchzell beendet, denn sein Beruf erfordert viel Zeit. Doch nicht nur das. […]

Wort zum Tag von Pfarrerin Sandra Kunz, Kirchgemeinde Trubschachen, BE

***THIS WAS RELEASED AS A SUBSCRIBER EPISODE IN 2023. WE COMBINED PART ONE AND TWO, SO THE FLOW IS A LITTLE DIFFERENT THAN OUR USUAL SHOW.***JULY 10, 2015: Two-year-old DeOrr Kunz Jr (aka, Little Man) went on a camping trip with his mother and father, his great-grandfather, and a family friend. But somehow, tragedy struck this family during the trip.DeOrr had vanished in the Idaho wilderness. Or did he?Where is DeOrr Kunz Jr.?***********************Follow us on: Facebook: www.facebook.com/wherearetheypodcast Instagram: @thewherearetheypodcast Email me: Canwefindthem@gmail.com Join our online detective group at Patreon: ⁠⁠⁠⁠www.patreon.com/wherearetheypodcast⁠⁠⁠⁠Support our mission: ⁠⁠⁠⁠https://www.buymeacoffee.com/wherearethey⁠⁠

In this conversation, Hunter Clarke-Fields and Chinyelu Kunz explore the significance of rhythm in parenting, discussing how it fosters stability and flexibility in children. They delve into the practical implementation of daily rhythms, the holistic approach of Waldorf education, and the challenges of navigating technology and screen time in modern parenting. Chinyelu emphasizes the importance of empowering parents to trust their instincts and create nurturing environments for their children. ABOUT HUNTER CLARKE-FIELDS: Hunter Clarke-Fields is the host Mindful Parenting Podcast (Top 0.5% podcast ), global speaker, number 1 bestselling author of “Raising Good Humans” and “Raising Good Humans Every Day,” Mindfulness Meditation teacher and creator of the Mindful Parenting Course and Teacher Training. Find more podcasts, Hunter's books, blog posts, free resources, and more at ⁠MindfulMamaMentor.com⁠. Discover your Unique-To-You Podcast Playlist at ⁠mindfulmamamentor.com/quiz/⁠ We love the sponsors that make this show possible! You can always find all the special deals and codes for all our current sponsors on our website: ⁠/mindfulmamamentor.com/mindful-mama-podcast-sponsors/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Mona Kuhn discusses her recent artistic shift towards multimedia projects, specifically her "Kings Road" series. She explains that after years of focusing on traditional photography and print making, she felt the need to explore new avenues post-pandemic. This led her to create a 12-minute film composed of still photographs that are projected onto multiple walls, creating an immersive experience. The project, which also incorporates an original score by her husband, a composer, traveled extensively to various museums, including the Arts Design and Architecture Museum in Santa Barbara, the Kunz house, and a museum in China. Kuhn highlights how the addition of music influences the viewer's experience, impacting their pace and emotional connection to the work. The projections were shown alongside her traditional prints in a separate room, emphasizing the scale and cinematic nature of the multimedia installation.Show Clip from The Paris Chong Show with Mona Kuhnhttps://youtu.be/0hOYuPcKGVkhttps://www.theparischongshow.com

In March 1998, Father Alfred Kunz was murdered inside St. Michael Catholic Church in Dane, Wisconsin. Many believe he was murdered because he had knowledge of sexual misconduct within the church, while others say he was murdered because of allegedly inappropriate relationships with female parishioners. Join Mike and Gibby as they discuss the murder of Father Alfred Kunz. There have been no shortages of suspects in this case over the years. But, one by one, the police have ruled people out using DNA found at the crime scene. The theories in the case range from greed, inappropriate relationships, to the possibility that Kunz was about to go public with a list of priests who had committed sexual offenses.You can help support the show at patreon.com/truecrimeallthetimeVisit the show's website at truecrimeallthetime.com for contact, merchandise, and donation informationAn Emash Digital productionSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Der Teilhaber stürzt aus dem 10. Stock – und der Chef ist verschwunden! Im Bauunternehmen «Kunz AG» geht es drunter und drüber. Madeleine arbeitet dort als Sekretärin – und stösst auf lauter Ungereimtheiten im Todesfall. Dabei deckt sie auch ziemliche dubiose Geschäftspraktiken auf ... (00:00) Beginn Episode (02:39) Beginn Hörspiel (51:49) Gespräch ____________________ Die handelnden Figuren: · Manfred Kunz – Chef der Firma «Kunz AG», Bauunternehmer auf der Sonnenseite des Lebens · Peter Lüthi – Teilhaber der «Kunz AG», Chefingenieur, Bauunternehmer auf der Schattenseite des Lebens · Urs von Bergen – junger, aufstrebender, noch recht neuer Mitarbeiter bei Kunz, Ingenieur und Bauführer · Madeleine Habegger – Sekretärin von Kunz · Annemarie – Sekretärin von Lüthi und (später) beste Freundin von Madeleine · Alexander Pavlicek – Architekt beim Architekturbüro «Sterli und Hirth», beauftragt von Kunz · Arnold Mosimann – Banker · Giovanni di Pietro – Vorarbeiter · Werner Schlegel – Kondukteur in der Geisterbahn & Komplize ____________________ Mit: Franz Matter (Kunz), Birgit Steinegger (Frau Kunz), Yvonne Roth (Madeleine), Peter Wyss (Lüthi), Dori Grob (Annemarie), Peter Holliger (von Bergen), Dieter Stoll (Pavlicek), Paul-Felix Binz (Mosimann), Rainer Zur Linde (Schlegel), Eleonore Bürcher (Frau Dufaud), Peter Freiburghaus (Giovanni), Liselotte Favri (Serviertochter), Max Begert (Polizist), Daniel Kasztura(Polizist), Kurt Frauchiger (Polizist), Hans-Rudolf Spühler (Polizist), Hanspeter Otti (Hausmeister), Erwin Leimbacher (Kellner), Rolf Schwab (Kondukteur), Charlotte Acklin (Barmaid), Charles Benoit (Taxifahrer), Max Füri (Autofahrer, Telefonstimme) ____________________ Tontechnik: Werner Feldmann – Regie: Charles Benoît ____________________ Produktion: SRF 1980 ____________________ Das andere Hörspiel mit Madeleine als Ermittlerin könnt Ihr hier nachhören: https://www.srf.ch/audio/krimi/1-2-draeckegi-woesch-gespraech?id=54108079-cf03-45be-9c89-da400a9824af https://www.srf.ch/audio/krimi/2-2-draeckegi-woesch-gespraech?id=69bdc6c9-9e91-4a64-aa93-35110d790f9e Das Theaterstück von Markus Keller und Rusudani Tabukaschwili läuft momentan in Bern: https://www.theater-effinger.ch/premieren/eine-besondere-strasse

Ingenieur Lüthi stürzt zu Tode – auf der Baustelle seines Unternehmens. Alles sieht nach einem Unfall aus. Doch seine Sekretärin Madeleine bekommt einen Verdacht: War es Selbstmord? Oder sogar ... Mord! Wunderbar lebensnaher Krimi aus der Schweiz. (00:00) Beginn Episode (02:58) Beginn Hörspiel (47:04) Gespräch ____________________ Die handelnden Figuren: · Manfred Kunz – Chef der Firma «Kunz AG», Bauunternehmer auf der Sonnenseite des Lebens · Peter Lüthi – Teilhaber der «Kunz AG», Chefingenieur, Bauunternehmer auf der Schattenseite des Lebens · Urs von Bergen – junger, aufstrebender, noch recht neuer Mitarbeiter bei Kunz, Ingenieur und Bauführer · Madeleine Habegger – Sekretärin von Kunz · Annemarie – Sekretärin von Lüthi und (später) beste Freundin von Madeleine · Alexander Pavlicek – Architekt beim Architekturbüro «Sterli und Hirth», beauftragt von Kunz · Arnold Mosimann – Banker · Giovanni di Pietro – Vorarbeiter ____________________ Mit: Franz Matter (Kunz), Birgit Steinegger (Frau Kunz), Yvonne Roth (Madeleine), Peter Wyss (Lüthi), Dori Grob (Annemarie), Peter Holliger (von Bergen), Dieter Stoll (Pavlicek), Paul-Felix Binz (Mosimann), Rainer Zur Linde (Schlegel), Eleonore Bürcher (Frau Dufaud), Peter Freiburghaus (Giovanni), Liselotte Favri (Serviertochter), Max Begert (Polizist), Daniel Kasztura(Polizist), Kurt Frauchiger (Polizist), Hans-Rudolf Spühler (Polizist), Hanspeter Otti (Hausmeister), Erwin Leimbacher (Kellner), Rolf Schwab (Kondukteur), Charlotte Acklin (Barmaid), Charles Benoit (Taxifahrer), Max Füri (Autofahrer, Telefonstimme) ____________________ Tontechnik: Werner Feldmann – Regie: Charles Benoît ____________________ Produktion: SRF 1980 ____________________ Das andere Hörspiel mit Madeleine als Ermittlerin könnt Ihr hier nachhören: https://www.srf.ch/audio/krimi/1-2-draeckegi-woesch-gespraech?id=54108079-cf03-45be-9c89-da400a9824af https://www.srf.ch/audio/krimi/2-2-draeckegi-woesch-gespraech?id=69bdc6c9-9e91-4a64-aa93-35110d790f9e Das Theaterstück von Markus Keller und Rusudani Tabukaschwili läuft momentan in Bern: https://www.theater-effinger.ch/premieren/eine-besondere-strasse

Gm! This week we're joined by Sergej Kunz to discuss 1inch's recent launch on Solana. We deep dive into building on the EVM vs SVM, 1inch's path forward, powering cross chain liquidity, how to improve execution & more. Enjoy! -- Follow Sergej: https://x.com/deacix Follow Jack: https://x.com/whosknave Follow Lightspeed: https://twitter.com/Lightspeedpodhq Subscribe to the Lightspeed Newsletter: https://blockworks.co/newsletter/lightspeed -- Grab your tickets to Permissionless IV. Use code LIGHTSPEED10 for 10% off: https://blockworks.co/event/permissionless-iv -- Get top market insights and the latest in crypto news. Subscribe to Blockworks Daily Newsletter: https://blockworks.co/newsletter/ -- Zenrock is a permissionless, decentralized custody network backed by 1RoundTable Partners, 10T, Maven11, and Spartan. Live on Jupiter, $ROCK is the native token for transactions within the Zenrock ecosystem and secures Zenrock's decentralized custody network. The first application launching on Zenrock is zenBTC – yield-bearing Bitcoin on Solana. zenBTC will be live in April 2025. Visit zenbtc.io to learn about earning yield with Bitcoin on Solana. -- (00:00) Introduction (01:24) Launching 1inch On Solana (08:15) Zenrock Ad (08:58) Execution On Solana (17:42) Building On The EVM vs SVM (20:58) Sandwich Attacks (28:17) Zenrock Ad (29:00) Building A DEX Aggregator Business (35:55) The Path Forward For 1inch (36:57) Cross Chain Liquidity (43:23) What's Next For 1inch? -- Disclaimers: Lightspeed was kickstarted by a grant from the Solana Foundation. Nothing said on Lightspeed is a recommendation to buy or sell securities or tokens. This podcast is for informational purposes only, and any views expressed by anyone on the show are solely our opinions, not financial advice. Mert, Jack, and our guests may hold positions in the companies, funds, or projects discussed.

Cult thinking. Groupthink. Black and white thinking. “Loud, vocal thinkers' and how extreme sound bites dominate the modern media landscape thanks to algorithms, painting a ‘majority picture' when most people are not living out those extremes in day-to-day lives.It's quite a time to be alive, and also a time when it's very easy to let the fear of something cloud our ability to judge the reality of a situation fully. Is “Apatheism” a new way forward? I've always been fascinated by people we turn into our saviours and gurus, as well as charismatic authoritarians who sweep in and seduce us in our personal or collective vulnerable times.. That moment we start rationalising and making excuses for a cult leader, where perhaps a couple of years ago, we'd have been dead against that very thing/person we now defend.On Monday, I explore the murky waters of freedom, autonomy, cults and social systems with Professor of Political Science and Constitutional Law, Adam Scott Kunz, who specialises in cults and political philosophy and has worked alongside the famed Dr Janja Lalich, considered a global authority on cults, until her recent retirement.This show is NOT an attack on anyone, your beliefs, your religion, the diet you feel healthiest on or other held views, but a show to see how we can ensure we are “critical thinking” and not just believing we are, and how we can balance beliefs with values with freedom and come together on common overlaps that benefit us all and how we all struggle with freedom and belonging and ‘others'. One thing I know for sure after this conversation is that the best thing is to know we don't know anything for sure. So there you go! I hope you tune into this fascinating exploration… Alexx xWant to learn more about this week's guest? Website: www.adamkunz.com Thank you to this month's show partners for joining us to help you make your low tox swaps! @ausclimate is our major partner giving you 10% off their range for 2025, with Winix Air Purifiers, Dehumidifiers and their new energy-efficient heating, air-circulating and cooling range. code LOWTOXLIFE (also works over and above their sales - pro tip!) https://bit.ly/ShopAusclimate@ediblebeautyau has put together a generous offer for us - 30% off for the month of May with code: LOWTOXLIFE. Seriously. Why not indulge yourself in the ultimate low tox facial, for some self-pampering this month?!Be sure to join me on Instagram @lowtoxlife and tag me with your shares and AHAs.Want to support the Low Tox Life podcast?Free option: Leave a 5 star review wherever you listen to Low Tox Life - thanks SO much!Paid + Member PERKS: Join the Low Tox Club - monthly practitioner live masterclasses, a suite of low tox store discounts from around the world and the most supportive and lovely chat group on all low tox topics on the internet: Check it out and join here for just the price of a coffee per month! Hosted on Acast. See acast.com/privacy for more information.

Danielle Kunz Dwyer, founder of Yoga For You, talks with J about organizing a business and being together in a more expansive state. They discuss connecting via email and open sourcing info on how to go online, studying Ayurveda and yoga in NYC in the early aughts, periods of unknowing, unwinding of identity, students and subscriptions, honoring yourself and valuing teachers, opening a center and pandemic policies, profitability of the yoga profession, foundations of trust, and what really grows someone in their practice.   To subscribe and support the show… GET PREMIUM. Say thank you - buy J a coffee. Check out J's other podcast… J. BROWN YOGA THOUGHTS.    

Karen Conti chats with Dr. Adam Kunz, assistant professor at University of Wisconsin-Eau Claire, about the First Amendment and if it allows cult organizations to brainwash people. Dr. Kunz also talks about what can be done legally to extricate cult members from those organizations.

In der aktuellen Folge von Wirtschaft Düsseldorf Unplugged spricht Moderatorin Andrea Greuner mit Alesia Kunz, Gründerin von LearnSlice – einem bootstrapped Unternehmen aus Düsseldorf, das Firmen dabei hilft, Talente zu gewinnen, langfristig zu binden und wertvolles Wissen effizient zu sichern.  

About the series: It's not just a relationship, a purchase, or a decision. It's a path. Every path has a destination. In the end, we will end up at the destination from the path we have chosen to take. With driving or hiking, getting lost will cost us minutes or hours. With life, it will cost us years!   About this week's message: We are surrounded with advertisements calling out to us to purchase their product. The ads use subtle hooks to lure people to buy. Hooks such as, “You need this!” “Everyone has this!” “Don't think, just buy it!” Too many people are living in financial bondage as a result. They unknowingly walked a path that led them to ruin and destruction.   Key Phrase: “Be very careful, then, how you live – not unwise but as wise.”Ephesians 5:15

Want to fall in love with your ADHD brain and make it work for you? Learn more about my patented program, Your ADHD Brain is A-OK Academy here: programs.tracyotsuka.com/signup__Growing up as the youngest of ten kids, Chelsea Kunz learned early how to be loud, funny, and grab attention—which, as it turns out, is pretty on-brand for an ADHD brain. Now an actor, creator, and self-described hot mess mom, Chelsea built an online following as Karen Disapproves, blending comedy and chaos into relatable parenting content. But behind the laughs, she's been on a deep dive into self-development, spirituality, and purpose, which led her to launch the Soul Slumber Party podcast.In this conversation, Chelsea shares her ADHD diagnosis journey, from being the class clown (and occasional teacher's nightmare) to struggling with focus, working memory, and traditional academics. She opens up about how ADHD showed up in motherhood, why she felt overwhelmed and irritable after having kids, and what finally led her to seek a diagnosis. Tracy and Chelsea also talk about nervous system regulation, how overstimulation can lead to emotional dysregulation, and why finding the right creative outlet can make all the difference for ADHD brains.Chelsea also breaks down how she balances big ideas, creative projects, and intuitive decision-making, from social media to screenwriting. If you've ever felt like you're juggling too much or struggling to follow through on what matters most, this conversation will leave you laughing, nodding along, and maybe even rethinking how you approach your creativity.Resources:Instagram: https://www.instagram.com/soulslumberparty YouTube: https://www.youtube.com/@soulslumberparty TikTok: https://www.tiktok.com/@soulslumberparty Send a Message: Your Name | Email | Message Learn more by connecting with Tracy through Instagram, Facebook, LinkedIn, Pinterest, or visit adhdforsmartwomen.com.Are You Ready to Discover Your Brilliance? Order Now: https://adhdforsmartwomen.com/bookJoin Your ADHD Brain is A-OK: https://adhdforsmartwomen.com/aokVisit our website: https://adhdforsmartwomen.comJoin our community of ADHD For Smart Ass Women: https://www.facebook.com/groups/tracyotsuka Join What Do I Do With My Life Masterclass: spyhappy.me/classUnlock your best days with Blends: https://adhdforsmartwomen.com/blends

In this episode, artist Rebecca Lee Kunz takes us behind the scenes of her Caldecott Medal winning book, CHOOCH HELPED (written by Andrea L. Rogers

On March 4th 1998 Father Alfred Kunz was found brutally murdered in the one place he should've felt the safest. Listen in as we deep dive into a tale full of twists, turns and whacky characters. Watch this episode on YouTube: YouTube.com/@cultliterCall the Hotline: 747-322-0273Buy my book: prh.com/obitchuaryMerch! Merch! Merch!: wonderyshop.com/cultliterCome see me on tour: obitchuarypodcast.com Write me: spencer@cultliter.comSpencer Henry PO Box 18149 Long Beach CA 90807 Follow along online: instagram.com/cultliterpodcast instagram.com/spencerhenryJoin our patreon: Patreon.com/cultliterCheck out my other show OBITCHUARY wherever you're listening now! Sources: https://news.google.com/newspapers?id=pytFAAAAIBAJ&sjid=XbsMAAAAIBAJ&pg=3019,1276199&dq=alfred-kunz+dane&hl=enhttps://en.wikipedia.org/wiki/Murder_of_Alfred_Kunzhttps://captimes.com/news/local/crime_and_courts/to-catch-a-cold/article_d974937f-f98a-55a1-a41d-aa7a6d55a6c4.htmlhttps://chucknowlen.com/kunz.htmhttps://s3.documentcloud.org/documents/5691267/Chapter-one-documents.pdfhttps://s3.documentcloud.org/documents/5684948/Kunz-Homicide-Report.pdfhttps://www.catholicworldreport.com/2018/08/08/the-unsolved-murder-of-fr-alfred-kunz/https://www.catholicworldreport.com/2018/08/15/i-dont-know-if-they-will-ever-reveal-why-he-was-murdered/https://www.catholicworldreport.com/2018/08/22/detectives-hope-trail-wont-go-cold-in-priests-murder-probe/https://projects.jsonline.com/topics/unsolved/season-three/chapter-2-instruct-the-ignorant.htmlhttps://projects.jsonline.com/topics/unsolved/season-three/the-devil-you-know.htmlhttps://s3.documentcloud.org/documents/5684950/Cavanaugh-Criminal-Complaint.pdfhttps://s3.documentcloud.org/documents/5684951/Death-Investigation-March-25-1998.pdfhttps://s3.documentcloud.org/documents/5684952/Updated-Homicide-Report-Dec-17-2000.pdfhttps://www.chicagotribune.com/2005/02/06/some-call-him-priest-church-calls-him-fake/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I can't imagine hosting a podcast about grief and not having a conversation about suffering and how we understand its role and impact in our lives.Today's episode is a nod to my 16 year old self, who having experienced some life changing events already, craved conversations that could help me make sense of the suffering I had witnessed.With me today to dive deep, is my friend Tamal. He is a mentor, storyteller, social-philosopher, retreat-leader and ceremonialist. He is also a painter, dancer, hermit and preposterous clown.Tamal has been studying and teaching ancestral wisdom traditions for 27 years. Among other things, he was a monk for 11 years based in India, and trained in shamanism in Peru for 4 years after that. His summary conclusion about life is that the task is to transform our paradigm of duality into one of polarity. A fundamental part of this process is a re-orientation toward suffering.We discuss his perspective on why looking directly at our own suffering, as well as that of those around us—in our homes, communities, and globally—can help us become more loving, beautiful, and potent in our service and our callings.Imagine what can shift in our lives when we allow ourselves to be honest about the effects of our suffering, name our confusion and doubt, and dive deep beneath the surface to connect to sacred wisdom.If you are someone who has wrestled with your own faith while suffering, no matter the framework of belief you come from, I believe this conversation will encourage you in your deeper exploration.Push play, share and subscribe (of course)!Also, thank you for supporting the show!-RachelWhere to Find Tamal:Moonshine Mundali CommunityInstagram: @Tamal.Kunj

In this solo episode, Chelsea Kunz talks about her personal journey with self-love, authenticity, and embracing her inner magic. Chelsea explores candid topics such as overcoming self-doubt, redefining self-love, and identifying limiting beliefs. She shares profound insights gained from sleepless nights, group meditations, and even quirky experiments with AI. Tune in for heartfelt advice, practical exercises, and Chelsea's unique, humorous perspective on unlocking the divine creator within us all. Soul Slumber Party Soul Slumber Party InstagramSoul Slumber Party TikTok Soul Slumber Party FacebookShow Inquiries soulslumberpartypod@gmail.com

Dr. Shaalan Beg and Dr. David Wang discuss key abstracts in GI cancers from the 2025 ASCO Gastrointestinal Cancers Symposium, including major advances in CRC, neoadjuvant approaches in esophageal cancer, and innovative studies on ctDNA. TRANSCRIPT Dr. Shaalan Beg: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Shaalan Beg. I'm a medical oncologist and an adjunct associate professor at UT Southwestern Medical Center in Dallas. Today, we're bringing you some key highlights from the 2025 ASCO Gastrointestinal Cancers Symposium, and I'm delighted to be joined by the chair of GI25, Dr. David Wang. Dr. Wang is a GI medical oncologist at the University of Michigan. Our full disclosures are available in the transcript of this episode.  Dr. Wang, thanks for coming on the podcast today. Dr. David Wang: Well, thank you. It's a pleasure to be here. Dr. Shaalan Beg: GI25 featured major therapeutic advances across the spectrum of GI malignancies, and it was exciting to hear about innovations and novel approaches that are shaping the future of our field. Before we start talking about specific abstracts, could you share some of your key highlights from the meeting? Dr. David Wang: Sure. Our theme this year was “Breaking Boundaries to Enhance Patient Centered Care.” Past years' themes have focused more on precision oncology, but we wanted to broaden our focus on patients and to be more holistic, which kind of led us into some of the Intersection [sessions] that we had. Each day started with a different Intersection. The first one was “Emerging Therapies in GI Cancers”, where invited speakers talked about bispecific antibody drug conjugates, theranostics, CAR T and other cell-based therapies. The second day was on “Personalized Risk Assessment for GI Cancers,” and this included looking at polygenic risk scores for colorectal cancer, microRNAs and liquid biopsies such as exosomes and pancreatic cancer and non-endoscopic screening modalities in esophageal cancer. And on our final day, we wanted to talk about “Integrative Oncology and Integrative Medicine,” looking at evidence-based uses of acupuncture and supplements in patients who are receiving treatment for cancer, mindfulness-based practices and exercise. And of course, we had a fantastic keynote talk by Dr. Pamela Kunz from the Yale School of Medicine titled, “Disrupting Gastrointestinal Oncology: Shattering Barriers with Inclusive Science.” She highlighted the intersection of science, patient care, and health and gender equity. And I would encourage your podcast listeners to access the lecture in ASCO's Meeting Library if they haven't yet had a chance to hear Dr. Kunz's wonderful lecture.  We were really happy this year because the attendance hit a new record. We had over 5,000 people attend either in person or virtually from their home or office, and we had almost 1,000 abstracts submitted to the meeting, so these were either record or near record numbers. We offered a lot of different networking opportunities throughout the meeting, and attending found these to be incredibly rewarding and important and this will continue to be an area of emphasis in future meetings. Dr. Shaalan Beg: Let's take a deeper dive into the exciting studies presented at GI25. The late breaking abstract LBA143 was CheckMate-8HW. This was the first results of NIVO + IPI versus NIVO monotherapy for MSI-high metastatic colorectal cancer. What are your thoughts about this study? Dr. David Wang: Yeah, so we know that colorectal cancer patients with MSI-high tumors don't necessarily respond well to chemotherapy. And we were fortunate because last year CheckMate-8HW actually looked at two different arms – so this was NIVO + IPI compared to standard of care chemotherapy and showed its very significant improvement in median progression-free survival. And that was actually published in the New England Journal of Medicine back in November of 2024. This year's presentation actually focused now on NIVO + IPI versus NIVO monotherapy. And as you know IPI+NIVO can be quite toxic. So this was an important analysis to be done. So we know that NIVO is definitely more easily tolerated. So what was interesting was that the 2-year and 3-year progression-free survival not surprisingly favored IPI+NIVO and this was statistically significant. And the overall response rate was also better with IPI+NIVO versus NIVO alone. I know we're always concerned about toxicities and there were higher grade 3 and 4 toxicity incidences in the combination arm versus the monotherapy arm, but overall, only about 28 additional events in several hundred patients treated. So I think that's well-tolerated. Our discussant Dr. Wells Messersmith actually said that, with this new data, he would consider doing combination immunotherapy in any patient that presented in the front line with MSI-high or deficient mismatch repair colorectal cancer that was metastatic. Dr. Shaalan Beg: One of the focuses for directing first-line therapy for colorectal cancer has been right and left sided colon cancer because we know these are two different cancers with their own unique molecular subtypes. We heard on Abstract 17, the DEEPER trial, the final analysis of modified FOLFOXIRI plus cetuximab versus bevacizumab for RAS wild-type and left sided metastatic colorectal cancer. How do you summarize the findings of this study and what should our readers be aware of? Dr. David Wang: Interestingly, this was a phase 2 study and the emphasis of the abstract was actually a subgroup analysis of those patients with RAS wild-type and BRAF wild-type as well as left sided cancers. So, I think the entire study enrolled 359 patients, but the analysis that was discussed at the meeting really focused on 178 patients that fit that characteristic. Very similar to what we've seen in prior studies, left-sided tumors have better response to cetuximab versus bevacizumab. And if you flip it so that you now are looking at right sided tumors, targeting EGFR is actually detrimental. The depth of response was better with cetuximab in these left sided RAS and BRAF mutant tumors. And so the lead author actually suggested that this could be a new first-line standard of care. And the question is, is there a benefit of doing this triple agent regimen with modified FOLFIRINOX? We know there's a lot more toxicity with that. Not clear that there's a benefit for that over FOLFOX, maybe in younger patients that could tolerate it. When our discussant, again Dr. Wells Messersmith, spoke about this, he said that, in his practice he would, again, favor cetuximab over bevacizumab in combination with chemo, these left-sided RAS and BRAF wild-type tumors, but that he would actually prefer a doublet versus a triplet chemo regimen, and that is consistent with the current NCCN guidelines. Dr. Shaalan Beg: Another area where colorectal cancer has been a wonderful model to study new technology has been in the area of circulating tumor DNA (ctDNA). And the BESPOKE CRC trial is looking to see if ctDNA can inform adjuvant treatment decisions for stage II and III colorectal cancer. And in Abstract 15, we heard final results of the BESPOKE CRC sub-cohort. What were the findings there? Dr. David Wang: BESPOKE CRC is another one of these important ctDNA studies. It was an observational study, not a randomized trial, but it did provide a lot of different insights to us. We know that there were over 1,700 patients enrolled, and so it was reported that this is the largest ctDNA study in colorectal cancer performed in the United States. And they were able to analyze over 1,100 patients.  Some of the key findings were that postoperative adjuvant therapy management decisions actually changed in 1 out of 6 patients, so that's pretty significant. In terms of surveillance, we know that patients who have ctDNA positivity, this is prognostic of recurrence. In terms of patients who have positive ctDNA post-surgery, it looked like, at least in this observational study, the majority of patients who received any benefit were those who had positive ctDNA. So adjuvant therapy, even in stage II and stage III patients seemed to only benefit those patients who have positive ctDNA. I think that does raise the question, and this also was brought up in the discussion, which is “Can we de-escalate adjuvant therapy in terms of patients who are ctDNA-negative post-op?” And Dr. Richard Kim from Moffitt felt that we are not yet there. Obviously, we need randomized control trials where we are taking ctDNA results and then randomizing patients to receive adjuvant or non-adjuvant to really know the difference.  Other questions that come up with use of ctDNA include: What do you do with these patients who turn positive? This study for BESPOKE actually followed patients out to two years after surgery. So what you do with a positive ctDNA result wasn't really clear. It seems to suggest that once you turn positive, patients go on to more intensive surveillance. You know, again as an observation, patients who did turn positive were able to go to metastasis-directed therapy much more quickly. And again, this was supposedly to improve their curative intent therapy. And I think the other question that has been brought up all the time is, is this really cost effective? Patients want to know, and we want to give patients that information, but I think we're still stuck with what to do with a positive ctDNA level in a patient that's on surveillance because no randomized control studies have actually suggested that we need to start systemic therapy right away. Dr. Shaalan Beg: Yeah. And I guess in terms of practice informing or practice changing, these results may not give us a clear answer. But because a lot of patients are asking for these tests, it does give us some real world experiences on what to expect in terms of conversion of these positive into negative and the outcome so we can have a shared decision making with our patients in the clinic and then come up with a determination on whether ctDNA for molecular residual disease is something which would be worthwhile for the care of our patient. But more to come, I guess, in coming years to answer different problems around this challenge. Dr. David Wang: Yes, I agree. Dr. Shaalan Beg: The BREAKWATER trial looked at the use of encorafenib, cetuximab and chemotherapy for BRAF V600E-mutant metastatic colorectal cancer. We've covered this combination for a second- third-line treatment in metastatic colorectal cancer previously. Abstract 16 from GI25 was evaluating the use of this regimen in the first-line space. Everyone was looking forward to these results, and what did the investigators present? Dr. David Wang: I think this is, as you mentioned, a nice follow up to later lines of therapy where Dr. Kopetz from MD Anderson pioneered use of encorafenib, cetuximab and binimetinib in the BEACON trial. Everybody was kind of curious what would happen now if you use encorafenib plus cetuximab plus chemotherapy in the first-line setting. And so this is an interim analysis that was pre-planned in the phase 3 open label BREAKWATER trial. And even though there were three arms, and so the three arms were encorafenib plus cetuximab, encorafenib plus cetuximab plus FOLFOX, or standard of care chemo, only two arms were presented in the abstract. So basically looking at encorafenib plus cetuximab and FOLFOX-6 versus standard of care therapy, and the overall response rate was statistically significant with a 60.9% overall response rate encorafenib plus cetuximab plus chemo arm versus standard of care chemo was only 40%. The interim overall survival also was different. It was 92% versus 87% at 6 months and 79% versus 66% at 12 months, again favoring the chemotherapy plus encorafenib plus cetuximab. In terms of the statistics, the p was 0.0004. However, the pre-plan analysis required the p-value to be 1x10 to the -8. And so even though this looks really good, it hasn't quite met its pre-specified significance level. The good thing is that this is only interim analysis and the study is ongoing with future analysis planned.  So the real question is: Does it matter when we actually use this regimen? We know that the regimen's approved in the second third-line setting. What about in the first line? And there was some preclinical data that the discussant reviewed that shows that patients actually benefit if this is done in the first-line setting. For example, there was some preclinical data showing that even FOLFIRI, for example, can upregulate RAS, which would make tumors more resistant to this combination. This was thought to be practice-changing in a patient that has B600E showing up treatment naive that we should probably consider this regimen. And actually this did receive accelerated FDA approval about a month ago. Dr. Shaalan Beg: Yeah, and for what it's worth, I put up a Twitter poll asking my Twitter followers on how the BREAKWATER trial results will change their approach for newly diagnosed BRAF mutated colorectal cancer. We got 112 responses; 72% said that they will incorporate encorafenib, cetuximab, FOLFOX for their frontline BRAF mutated patients. But 23% said that they would like to wait for overall survival results. Dr. David Wang: Wow, that's interesting. They really want that 1x10 to the -8. Dr. Shaalan Beg: I guess so. All right. Let's change gears and talk about esophageal cancer. LBA329 was the SCIENCE study which presented preliminary results from a randomized phase 3 trial comparing sintilimab and chemoradiotherapy plus sintilimab versus chemoradiotherapy for neoadjuvant resectable locally advanced squamous esophageal cancer. Where are we in this space? Dr. David Wang: Okay. So, yeah, this was an interesting trial. Again, just to set the context, esophageal squamous cell carcinoma is more prevalent in Asia. And the study sites as well as the patients were mostly from Asia. So this was again a phase 3 trial with interim results. They only rolled 146 out of the planned 420 for this interim analysis. And yeah, they're using immune checkpoint inhibitor that we don't use in the United States, sintilimab, combined with their two standards of neoadjuvant therapy, either chemotherapy, which is more common in Asia, or or chemoradiation, which is more common in the US and Western Europe, versus chemoradiation. And so they actually had two primary endpoints, but only were reporting one. So their two primary endpoints were pathCR and the other one was event-free survival. The event-free survival, again, was not reported at the meeting.  What they found was that in terms of pathCR rate, if you take the two arms that are really informative about that, chemoradiation plus sintilimab versus chemoradiation alone, the pathCR rate was 60% versus 47%. We know that chemo alone doesn't induce as much of a pathCR rate, and that was 13%. So it was found that the delta in terms of pathCR between the chemoradiation arms, one with sintilimab and one without, was significant. And this actually confirms data again from Asia, like for the ESCORT-NEO trial where it used another immune checkpoint inhibitor pembrolizumab in addition to neoadjuvant chemo.  So as our discussant for this abstract said, yes, we know that radiation combined with chemotherapy improves pathCR rates, but we have recent data from the ESOPEC trial, we don't know that that necessarily will translate to overall survival. So again, waiting for additional enrollments and longer term follow up before incorporating this into clinical care here. Dr. Shaalan Beg: So David, how do the results of the SCIENCE trial compare with our practice in the United States and ongoing studies asking questions for neoadjuvant therapy for esophageal carcinoma in the United States? Dr. David Wang: I think obviously immune checkpoint inhibitor in the new adjuvant setting is important. Jennifer Eads at UPenn is running that EA2174 which is looking at chemoradiation plus or minus nivolumab, and then in non-pathCR responders randomized to adjuvant nivolumab per CheckMate 577 or nivolumab with intensification adding ipilimumab. We know that the ESOPEC trial just came out, and was published actually during the meeting, and that really focuses on adenocarcinomas. So adenocarcinomas of the GE junction, distal esophagus, now, we would probably treat very similarly to gastric using perioperative FLOT. However, the standard in the US for esophageal squamous cell carcinoma remains neoadjuvant chemoradiation. We know that squamous cell carcinomas are more exquisitely sensitive to radiotherapy. And then obviously in those patients who don't achieve a pathologic complete response, the expectation would be that they would go on to receive nivolumab per CheckMate 577. Again, the thought is that these tumors are more sensitive to immunotherapy given their higher incidences of mutational changes. And so again, this kind of goes along with the positive results seen in the SCIENCE trial that we just discussed with sintilimab but also EFFECT-neo with pembrolizumab. Obviously, we await the results of Jennifer's trial. Dr. Shaalan Beg: And the last abstract I was hoping we could get your perspective on was Abstract 652, which is a Phase 3 study of everolimus plus lanreotide versus everolimus monotherapy for unresectable or recurrent gastroenteropancreatic neuroendocrine tumors, the STARTER-NET trial. What were the results of this study? Dr. David Wang: So, I just want to give a shout out because we did have a session at this year's GI ASCO that looked at more rare tumors. So appendiceal tumors, neuroendocrine tumors, those kinds of things. So again, I would encourage your listeners to listen to that session if they have interest in that. Another type of rare tumor was adenosquamous tumors.  But in terms of the STARTER-NET trial, this was again an interim analysis of his phase 3trial and it was looking at combining everolimus plus lanreotide versus everolimus. So we know that in pancreatic-gastric neuroendocrine tumors, if you have low Ki-67, a well differentiated tumor, that the standard of care really is a somatostatin analog, and sometimes if they're more aggressive, we kind of consider molecular targeted therapy with everolimus. This was asking the question of whether we should do the combination on the frontline. And what was interesting is in this study, the patients were actually more of a poor prognostic set. So they had Ki-67 up to 20% or these were patients that actually had multiple liver lesions. And what they found was a median for progression free survival was improved with a combination out to 29.7 months versus 11.5 months with the somatostatin analog alone, and that the overall response rate was 23% versus 8.3%, again, favoring the combination. If you looked at subgroup analysis, it was actually those patients who had Ki-67 greater than 10%, so the more aggressive tumors, or those with diffuse liver lesions that had the most benefit. So I think that would be the patient population I would consider this new combination with using would be those patients again with poorer prognosis neuroendocrine tumor phenotype. Dr. Shaalan Beg: Thank you very much, Dr. Wang, for sharing your insights with us today and your great work to build a robust GI Cancers Symposium this year. Dr. David Wang: Well, thank you. I mean that really is a cooperative effort. We appreciate all the members of the GI25 Program Committee as well as the ASCO staff that just made it an outstanding meeting. Dr. Shaalan Beg: And thank you to all our listeners for your time today. You'll find links to the abstracts discussed today on the transcript of this episode.  Finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:  Dr. Shaalan Beg @ShaalanBeg  Dr. David Wang Follow ASCO on social media:   @ASCO on Twitter  @ASCO on BlueSky ASCO on Facebook   ASCO on LinkedIn   Disclosures:  Dr. Shaalan Beg:  Employment: Science 37  Consulting or Advisory Role: Ipsen, Array BioPharma, AstraZeneca/MedImmune, Cancer Commons, Legend Biotech, Foundation Medicine  Research Funding (Inst.): Bristol-Myers Squibb, AstraZeneca/MedImmune, Merck Serono, Five Prime Therapeutics, MedImmune, Genentech, Immunesensor, Tolero Pharmaceuticals  Dr. David Wang: Honoraria:  Novartis Consulting or Advisory Role: Novartis, Cardinal Health, Bristol-Myers Squibb, BeiGene, Eisai  

Dior Kunz Jr., a two-year-old boy, went missing on July 10, 2015, during a camping trip at Timber Creek Campground in Idaho with his parents, Jessica Mitchell and Dior Kunz Sr., his great-grandfather Robert Walton, and a family friend, Isaac Reinwand. The parents reported leaving Dior with Walton briefly, but upon their return, he was gone, prompting an extensive search involving law enforcement, search dogs, helicopters, and volunteers. Despite thorough searches of the area, no evidence of Dior's whereabouts was found. Various theories, including accidental disappearance, animal attack, abduction, and foul play by those present, have been proposed, but no conclusive evidence has emerged. As of 2024, the case remains unsolved, with no new leads, leaving the mystery of Dior Kunz Jr.'s disappearance unresolved.Matthew Green, a 39-year-old math teacher and experienced outdoorsman, disappeared in July 2013 while on a solo hike near Mammoth Lakes, California. Despite extensive search efforts involving local authorities, volunteers, and advanced technology, no trace of him has ever been found. Matthew, who had a seizure disorder requiring daily medication, left his belongings at the campground, suggesting he intended only a short hike. His disappearance remains a mystery, with theories ranging from a medical emergency or hiking accident to more speculative ideas of foul play or voluntary disappearance. Over a decade later, his family continues to search for answers, utilizing newer search technology and maintaining hope for closure.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.