Podcasts about new models

In this episode, Conor and Jaeden unpack the recent release of OpenAI's 03 and 04 mini models, diving into their capabilities, user experience, and the integration of text and image processing. They explore what these advancements signal for the future of AI—and the path toward AGI. The conversation also emphasizes the importance of user literacy and community engagement as AI tools become increasingly powerful and accessible.Chapters00:00 OpenAI's Latest Releases: 03 and 04 Mini02:59 Model Capabilities and User Experience06:04 Integration of Text and Images08:57 The Future of AI: Towards AGI11:53 User Insights and Community EngagementAI Applied YouTube Channel: https://www.youtube.com/@AI-Applied-PodcastTry AI Box: ⁠⁠https://AIBox.ai/⁠⁠Conor's AI Course: https://www.ai-mindset.ai/coursesConor's AI Newsletter: https://www.ai-mindset.ai/Jaeden's AI Hustle Community: https://www.skool.com/aihustle/about

The 2025 Lucid Gravity marks a major step for Lucid Motors as it enters the hotly competitive luxury electric SUV market. With a bold aerodynamic design, three-row practicality, and up to 828 horsepower, the Gravity aims to combine performance and family-friendly utility in a premium package. By doing so, it seeks to upset the luxury SUV applecart as it rockets to the top of the pack. This past week, host Jack Nerad was one of a select few journalists to drive and road test the Gravity for the first time. During his stint behind the wheel, he sampled the Gravity's dynamic split personality. At once, it is a highly competent performance vehicle and a fully utilitarian SUV that can tow, haul and convey seven adults at a rate few are accustomed to. Powered by dual motors producing up to 828 horsepower and 909 lb-ft of torque, the Gravity can accelerate to 60 mph in a claimed 3.4 seconds. Its air suspension, rear-wheel steering, and adjustable ride height make it a surprisingly agile and adaptable vehicle, particularly given its 6,048-pound curb weight, while a Terrain Mode and 6,000-pound towing capacity further expand its versatility. But is it a vehicle you'd want to live with day-to-day, given the elevated level of several of its rivals? Nerad will offer his views. In our other road test, co-host Chris Teague takes one of the nation's most popular plug-in hybrid vehicles through its paces as winter turns to spring in Maine. As unlikely as it might seem, the Jeep Wrangler 4xe is among the best sellers among the much-misunderstood roster of PHEVs. Its credentials are strong, but, again, is it a wise choice given its premium price over other Wranglers? Teague and Nerad will weigh in. When it comes to family vehicles, the Hyundai Palisade has gained a reputation as a thinking person's choice. Now, Hyundai has just introduced the all-new 2026 version, and Nerad went behind the scenes for an exclusive interview with Hyundai Product Planning Manager Melvyn Bautista to take a deep dive into the vehicle. It is both Easter week and New York Auto Show week, so we have a lot of news from each. Easter in Moab, Utah, is one of the biggest off-road gatherings of the year, and Jeep and Ford are there showing off concept vehicles. We have the details. Several new models have been introduced in and around the New York show, and we'll tell you about cool vehicles from Kia, Toyota, Mercedes-Benz and Audi in this episode. Used car buyers might be in for a price shock in the next few weeks, and it has nothing to do with tariffs. We'll tell you more and, of course, we'll have the latest auto tariff news for you too. Austin Nerad 2007-2025Our beloved dog, Austin, went to heaven this week. We miss him so.   Jack Nerad's newest book Jack is now offering his newest crime novel, Only One Thing Stays the Same, at a pre-publication price of just $4.99. Click here to buy from Amazon at this special limited-time price. Matt DeLorenzo's Book Pick up a copy of co-host Matt DeLorenzo's terrific new book How to Buy an Affordable Electric Car: A Tightwad's Guide to EV Ownership. Brought to you by: • DrivingToday.com • Mercury Insurance: Find out how much you can save at DrivingToday.com/auto-insurance. • EMLandsea.com, publisher of Only One Thing Stays the Same and  Dance in the Dark We have a lot of shows for you this week. Chapters 00:00 What's Up and Personal Reflections 02:58 Jeep, Ford Concepts from Moab 05:50 Kia's New Models at the New York Show 07:40 Toyota GR Models and Special Editions 08:52 Mercedes-AMG E 53 Hybrid Wagon 10:06 Audi A6 Sedan Launch 11:07 Used Car Market Trends & Tariffs 12:52 2025 Jeep Wrangler 4xe Review 18:16 2025 Lucid Gravity Review 26:00 2026 Hyundai Palisade SUV Interview 40:00 Farewell Austin Nerad/Check Engine Light Keywords automotive news, Jeep, New York Auto Show, Kia, Toyota, Mercedes, Audi, used cars, electric vehicles, Hyundai Summary

Dental practice owners across the country are facing a critical challenge: how to continue growing when hygienists seem impossible to find. This shortage creates a frustrating bottleneck - you've got the new patients flowing in, your clinical skills are sharp, your systems are solid, but without adequate hygiene capacity, your practice hits a growth ceiling that feels impenetrable.The mathematics behind this problem are straightforward but concerning. A full-time hygienist seeing seven patients daily for four days weekly can accommodate 672 patients on a six-month recall schedule. For practices bringing in 80-100 new patients monthly with strong reappointment rates, a single hygienist reaches capacity within just eight months. This reality forces practice owners to make difficult decisions about resource allocation.Beyond simply raising compensation to attract scarce hygiene talent (though that may be necessary), savvy practice owners are deploying creative solutions: becoming more selective about recalls and building robust ASAP lists; extending recall intervals beyond the traditional six months for appropriate patients; restructuring patient flow to route new patients directly through doctor exams with same-day dentistry opportunities; and implementing assisted hygiene models to increase capacity. Each approach has merits and challenges, but combining these strategies can help practices continue growing despite staffing limitations.Remember that transparency with patients about industry-wide staffing challenges helps manage expectations, and consider that new patients often represent a population with greater immediate treatment needs than established patients who already receive regular care. By implementing these five practical solutions, you can continue growing your practice, serving your community effectively, and maintaining the profitability that supports your ideal lifestyle.Ready to implement systems that create freedom and profitability in your practice? Visit dentalpracticheroes.com to learn more about our training programs designed specifically for practice owners who want more time off while maintaining exceptional income.Text us your feedback! (please note: we cannot respond through this channel))Check out www.relevanceonlinemarketing.com if you want to get the same great marketing results as Dr. Etch. Mention DPH and get your first month FREE!Take Control of Your Practice and Your Life I help dentists take more time off while making more money through systematization, team empowerment, and creating leadership teams. Join the DPH Hero Collective and get the tools, training, and support you need to transform your practice: Team and Doctor Training for every aspect of Practice Management Comprehensive Training: Boost profit, efficiency, and team engagement. Live Q&A Sessions: Get personalized help when you need it most. Supportive Community: Connect with practice owners on the same journey. Editable Systems & Protocols: Standardize your operations effortlessly. Ready to build a practice that works for you? Visit www.DentalPracticeHeroes.com to learn more.

Nora Freeman Engstrom is a professor of law who says that in three-quarters of cases one or more of the parties lacks legal representation. Worse yet, often the litigants are involved in high-consequence civil cases where there is no right to a lawyer and costs are prohibitive. Some states are looking at alternatives including non-lawyer representation, curated legal help for low-income citizens, and even AI, as Engstrom tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Nora Freeman EngstromConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Nora Freeman Engstrom, a professor of law at Stanford University.(00:03:11) Path to Justice WorkNora's journey into legal ethics and justice reform.(00:04:46) Misconceptions About Civil CourtHow civil cases often involve one represented and one unrepresented party.(00:08:40) Limits of Judicial HelpWhy the U.S. adversarial system limits judicial involvement.(00:10:40) Problems with Self-HelpThe lack of reliable resources for people trying to represent themselves.(00:13:41) The Cost of Legal HelpThe high cost of representation and how legal aid is overwhelmed.(00:15:20) A Missing MiddleHow law lacks mid-level professionals to offer affordable legal help.(00:17:41) Expanding Legal AccessWhy law lacks mid-level roles and bans non-lawyer advice.(00:22:22) New Models for Legal SupportThe ways some states are testing trained non-lawyers to expand access.(00:27:22) Legal Help in the PastThe history of legal access, including lawyers in banks and auto clubs.(00:30:29) Legal ProtectionismHow depression-era protectionism led to today's lawyer-only model(00:32:48) The Role of AI in Legal AccessThe potential of AI for creating smarter legal tools for courts.(00:35:52) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

In this episode:▶️ We run through all the Adepticon reveals▶️ Give our thoughts on what GW got right and wrongAnd we ask some of the big questions:▶️ Who is still missing from the codex map?▶️ Is the Year of Chaos going to be any good?▶️ What the new mission deck means for 40kJoin this channel to get access to perks:https://www.youtube.com/channel/UCSSfQjuirZutfvEf6fc4Xmg/joinJoin our Patreon here: https://www.patreon.com/c/Worhammer40kJoin our FREE Discord here: need to add

Host Brian Walsh takes up ImpactAlpha's top stories with editor David Bank. Up this week: With proxy season here, how shareholders can apply a system stewardship model for the companies they own; why strategies to share the wealth via employee ownership are attracting popular support, and a look at our spring “Re:construction” tour, which offers a playbook for shared prosperity.Chapters(00:00) Proxy season insights(06:00) Employee ownership models(11:50) Re:construction and shared prosperityEvent RSVPs:North Carolina: Friday, April 4 - Building models for shared prosperity, UNC Chapel HillWashington, DC: April 8 - Purple Party, Boston: Saturday, April 12 - Boston International Film FestivalStory links:“Shareholders can fight back with system stewardship,” by The Shareholder Commons' Frederick AlexanderOwnership Call: impactalpha.com/calls and Youtube“A playbook of what and who is working to build prosperity for all,” and “‘Special Purpose Credit Programs' face the axe,” by David Bank

Host Brian Walsh takes up ImpactAlpha's top stories with editor David Bank. Up this week: With proxy season here, how shareholders can apply a system stewardship model for the companies they own; why strategies to share the wealth via employee ownership are attracting popular support, and a look at our spring “Re:construction” tour, which offers a playbook for shared prosperity.Chapters00:00 Proxy season insights06:00 Employee ownership models11:50 Re:construction and shared prosperityEvent RSVPs:North Carolina: Friday, April 4 - ⁠Building models for shared prosperity⁠, UNC Chapel HillWashington, DC: April 8 - ⁠Purple Party⁠,Boston: Saturday, April 12 - ⁠Boston International Film Festival⁠Story links:“⁠Shareholders can fight back with system stewardship⁠,” by The Shareholder Commons' Frederick AlexanderOwnership Call: ⁠impactalpha.com/calls⁠ and ⁠Youtube⁠“⁠A playbook of what and who is working to build prosperity for all⁠,” and “⁠‘Special Purpose Credit Programs' face the axe⁠,” by David Bank

Can you help me make more podcasts? Consider supporting me on Patreon as the service is 100% funded by you: https://EVne.ws/patreon You can read all the latest news on the blog here: https://EVne.ws/blog Subscribe for free and listen to the podcast on audio platforms: ➤ Apple: https://EVne.ws/apple ➤ YouTube Music: https://EVne.ws/youtubemusic ➤ Spotify: https://EVne.ws/spotify ➤ TuneIn: https://EVne.ws/tunein ➤ iHeart: https://EVne.ws/iheart RENAULT REVEALS R5 TURBO 3E SUPERCAR EV https://evne.ws/41Z98d8 BYD INTRODUCES SEALION 05 ELECTRIC SUV https://evne.ws/4bzPUzo VOLKSWAGEN INTRODUCES 11 NEW MODELS FOR CHINA https://evne.ws/41O0duY FOXCONN EYES EV PARTNERSHIPS WITH JAPANESE FIRMS https://evne.ws/41ye2h9 FORD URGES STRONGER GOVERNMENT SUPPORT FOR EVS https://evne.ws/4iBh1wx STELLANTIS COMMITS €38M TO VERRONE EV PLANT https://evne.ws/3DRa4bB BMW INCREASES EV SHARE TO 17.4% IN 2024 https://evne.ws/4izKVkp HYUNDAI AND KIA LEAD SOUTH KOREA'S EV MARKET SURGE https://evne.ws/3FAqPbE CAMDEN TO INSTALL 570 SIDEWALK EV CHARGERS BY 2026 https://evne.ws/4kYM1Ii HONDA TO SOURCE BATTERIES FROM TOYOTA'S NC PLANT https://evne.ws/4bX9Gou

First published in Heavy Traffic V (Fall 2024), Mark Leckey's kaleidoscopic, transhistorical sojourn into the Eikonomachia (the 'image struggle') is presented here in radio play form w/ sound design and production also by Leckey. This reading is part of Heavy Traffic's New Models residency, which features pieces from the magazine read aloud by their authors. Heavy Traffic V of is out now. https://heavytrafficmagazine.com See also: 

We're on with Morgane Billuart, a writer and artist and a researcher whose work engages critically with technologically mediated and determined worlds — not least within her exceptional book “Cycles, the Sacred and the Doomed: Inquiries in Female Health Technologies.” Morgane joins us to talk about a large, recent research project on a particular character that many of us identifies with, what Geert Lovink calls the “critical internet researcher” — a figure who engages in a kind of postdisciplinary media theory while at the same time producing and publishing their work through the very media they are studying, the Online. We strongly recommend:Morgane's podcasts Becoming the Product and Girl Employee with Carmen HinesMorgane's substack Becoming the ProductMorgane's book Cycles, the Sacred and the Doomed: Inquiries in Female Health Technologies on Set MarginsIn the episode we discuss the work of Geert Lovink and the Institute of Network Cultures and Joshua Citarella (and the associated entity Do Not Research), and we briefly touch on Yancy Strickler (and the associated MetaLabel), Trust, the New Center for Research and Practice, Are.na, New Models, and RADAR (https://www.radardao.xyz/). All are mentioned in the context of being institutions undertaking the extremely admirable charge of iterating upon new vehicles and structures for the exchange of information. Marek also briefly mentions the blogger RM (@NilsEdison) and the artist Maria Tsylke.

This is a preview | Full episode released to subscribers: 27 Oct 2024 | Subscribe --> https://newmodels.io Jay Springett is a writer, researcher, consultant, musician, podcaster, Royal Society of Arts Fellow, New Centre instructor, and decade long admin of solarpunks.net. Currently at work on a book exploring the history of Dungeons & Dragons (the so-called metaverse), Jay joins New Models to speak about the proliferation of “worlds” (perhaps in lieu of the 20th century public sphere) and strategies for existing within them. For more: thejaymo.net Jay's podcasts: https://thejaymo.net/permanentlymoved/ & https://experience.computer/

Happy New Year! This week Will, MikeW and Jeff recap the LVO/Everwinter and the Mutant Weekender, talk the new models releasing this week and preview the new crisis that have been revealed! Join our Discord: https://discord.gg/vYUHyCfZsT

This week we dig into your feedback, talk about an FPGA Playstation, and talk about Chinese AI. -- During The Show -- 00:50 Weather Unusual warm spell Extreme weather gear 03:00 Photos! - Anthony Flatbed scanner Handheld scanner Don't like the "scanning services" Epson Perfection Resolution of source material Canon LIdi Stay away from phones Make sure you have enough bandwidth 11:15 ttyusb - Jason Udev rules Ask an LLM 13:21 Cheque printing - Micah Use a template Quick Books Online 16:32 Questions - Atypical HACS (https://hacs.xyz/) Steve pulls several things from HACS BMC control in Home Assistant You do over extend yourself Can be deeply rewarding Have a prioritizing plan 25:36 News Wire MySQL 9.2 - mysql.com (https://dev.mysql.com/doc/relnotes/mysql/9.2/en/news-9-2-0.html) Dovecot 2.4 - dovecot.org (https://dovecot.org/mailman3/archives/list/dovecot-news@dovecot.org/thread/UYNR6GBP25XEGFCS633SWPR4HXV3NSS3/) Ventoy 1.1 - ventoy.net (https://ventoy.net/en/download.html) Gnome 46.8 - discourse.gnome.org (https://discourse.gnome.org/t/gnome-46-8-released/26405) Gnome 47.3 - discourse.gnome.org (https://discourse.gnome.org/t/gnome-47-3-released/26411) Wine 10.0 - gitlab.winehq.org (https://gitlab.winehq.org/wine/wine/-/releases/wine-10.0) Linux 6.13 - lkml.org (https://lkml.org/lkml/2025/1/19/281) GNU Linux-Libre 6.13 - fsfla.org (https://www.fsfla.org/pipermail/linux-libre/2025-January/003569.html) Rockoon - businesswire.com (https://www.businesswire.com/news/home/20250128753886/en/Mirantis-Launches-Open-Source-Software-that-Streamlines-OpenStack-Management-on-Kubernetes) Solus 4.7 - getsol.us (https://getsol.us/2025/01/26/solus-4-7-released/) BloodyAD - helpnetsecurity.com (https://www.helpnetsecurity.com/2025/01/28/bloodyad-active-directory-privilege-escalation/) Deepseek's New Models - hackaday.com (https://hackaday.com/2025/01/27/new-open-source-deepseek-v3-language-model-making-waves/) CISA Alert Power Grid PLC's put online Massive Change in Tech Industry Meta content moderation Deep Seek Hireing practices CISA (https://www.cisa.gov/news-events/alerts/2025/01/16/cisa-and-partners-release-call-action-close-national-software-understanding-gap) CISA PDF (https://www.cisa.gov/sites/default/files/2025-01/joint-guidance-closing-the-software-understanding-gap-508c.pdf) 32:11 Thunderbird Notifications Desktop notifications Matrix included 33:42 Nvidia's GeForce RTX 5090 very expensive Good GPU for AI/ML New Thermal Grease Different drivers for Quadro cards 40:30 FPGA Playstation One Emulator Clock speed Emulators get close enough Today's games will not be playable in future Industry has a cycle ArsTechnica (https://arstechnica.com/gadgets/2025/01/new-fpga-powered-retro-console-re-creates-the-playstation-one-cd-rom-drive-optional/) 47:50 DeepSeek DeepSeek Chinese AI DeepSeek claims to train on a fraction of time and money Worry is that it will over take US models Steve uses perplexity (https://www.perplexity.ai/) Real concern is great reduction required training resources -- The Extra Credit Section -- For links to the articles and material referenced in this week's episode check out this week's page from our podcast dashboard! This Episode's Podcast Dashboard (http://podcast.asknoahshow.com/425) Phone Systems for Ask Noah provided by Voxtelesys (http://www.voxtelesys.com/asknoah) Join us in our dedicated chatroom #GeekLab:linuxdelta.com on Matrix (https://element.linuxdelta.com/#/room/#geeklab:linuxdelta.com) -- Stay In Touch -- Find all the resources for this show on the Ask Noah Dashboard Ask Noah Dashboard (http://www.asknoahshow.com) Need more help than a radio show can offer? Altispeed provides commercial IT services and they're excited to offer you a great deal for listening to the Ask Noah Show. Call today and ask about the discount for listeners of the Ask Noah Show! Altispeed Technologies (http://www.altispeed.com/) Contact Noah live [at] asknoahshow.com -- Twitter -- Noah - Kernellinux (https://twitter.com/kernellinux) Ask Noah Show (https://twitter.com/asknoahshow) Altispeed Technologies (https://twitter.com/altispeed)

In Episode 205 The boys have a look at the Airfix and Italeri releases for 2025   You can leave a voicemail at  https://www.speakpipe.com/OTBvoicemail   Or write to us  Onthebench64@gmail.com.   Don't forget to support the sponsors of our show Scott from the Scale Modellers Supply  https://www.scalemodeller.com.au/   If you would like to support our show please go to www.patreon.com/onthebench   We recommend:-  Black Hat Models  https://www.youtube.com/@BlackHatScaleModels Workbench Hobbies  https://www.youtube.com/@workbenchhobbies4316

We're going ice fishing on this edition of the Angler Quest podcast with Captain Jason Graham of Send it Charters and Linwood Beach Marina. Jason talks about ice fishing on Saginaw Bay and has great tips for anglers targeting walleye there. Then the conversation turns to the new line up of Angler Quest.  Jason has lots of experience in selling and rigging AQ's and he's looking forward to working with the new models. Graham also describes the relationship between Linwood Beach and Angler Quest.  LBM was the first AQ dealer in the country and is still one of the biggest.  

Chinese firms continue to release AI models that rival the capabilities of systems developed by OpenAI and other U.S.-based AI companies. This week, MiniMax, an Alibaba- and Tencent-backed startup that has raised around $850 million in venture capital and is valued at more than $2.5 billion, debuted three new models: Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, The Car Chick discusses the latest trends in the automotive industry, focusing on the exciting new models set to be released in 2025. The conversation highlights the significant shift towards electric vehicles (EVs) and hybrids, as well as the continued presence of gas-powered models. LeeAnn shares her insights on various upcoming vehicles, including the Nissan Maxima EV, Kia EV3, and the return of the Honda Prelude as a hybrid. She also touches on the redesign of popular models like the Hyundai Palisade and Honda Passport, emphasizing the importance of affordability and practicality in the evolving automotive landscape.takeawaysElectric vehicles are becoming increasingly popular among manufacturers.The Nissan Maxima is returning as a fully electric vehicle.Kia's EV3 aims to provide an affordable electric SUV option.The Chevy Bolt is making a comeback with improved features.Honda is reviving the Prelude as a hybrid sports coupe.Mazda and Subaru are introducing new hybrid models.The redesigned Honda Passport will look more rugged.The redesigned Hyundai Palisade will include a hybrid option.Affordability remains a key concern in the automotive market.You can view a full list of resources and episode transcripts here. Connect with LeeAnn: Website Instagram Facebook YouTube Work with LeeAnn: Course: The No BS Guide to Buying a Car Car Buying Service Copyright ©2024 Women's Automotive Solutions Inc., dba The Car Chick. All rights reserved.

In this episode Will talks with John Karren, co-founder of Elements Programs. John reflects on how Elements has evolved over its 17-year history, moving from a strictly nomadic wilderness model to more flexible, tailored programs, including a new “Eclipse” option designed for neurodiverse adolescents. He explains the behind-the-scenes decisions that led them to integrate adventure activities, introduce heated tents, and adopt family-centric approaches, all while maintaining a commitment to the transformative power of the outdoors. John also discusses the critical role of collaboration with partners and clinical team members in shaping Elements' ongoing adaptations, from digital media overuse interventions to specialized programming for different client profiles. Beyond the Elements model, John and Will touch on broader challenges facing the outdoor behavioral healthcare field, particularly the recent industry contractions and heightened public scrutiny. John shares how being a small, owner-operated program with dedicated clinical professionals has enabled Elements to stay resilient. He speaks passionately about the need to eliminate outdated practices, embrace ethical oversight, and remain agile in responding to ever-changing mental health needs. This conversation offers a candid look at how one wilderness therapy program continues to innovate while retaining a deep respect for the outdoors as a powerful catalyst for growth and healing. Other podcast episodes related to Elements mentioned in this episode: Episode 44: Karen Scrafford, Co-founder of Elements Wilderness Therapy Episode 17: Lynn Smith, Co-founder of Elements Wilderness Program 98: Vicenzo Narciso, Undergraduate Student at San Diego Mesa College and Former Wilderness Therapy Student

On finishing the project of music, on TikTokCore and SpotifyCore, on music as cosplay and the technicity of cultural imperialism, on the bureaucratic turn in the arts, on being dangerous. Lecture given for my beloved DMR at Columbia University at the beginning of December. Feeling a bit bolder than usual on this one, but it's cuz my toddler is sleeping good.

HARDCORE CHRISTIANITY - The New Models - ThursdaySupport the show: https://hardcorechristianity.com/donations/See omnystudio.com/listener for privacy information.

Consolidating Higher Education: The Community Solution Model This episode of the Changing Higher Ed® podcast features Dr. Michael Horowitz, Chancellor of The Community Solution Education System (formerly TCS Education System), who discusses using innovative models for higher education consolidation as an additional category in or alternative to traditional mergers or acquisitions. Horowitz highlights the system's unique approach, a collaborative model prioritizing resource optimization and expertise sharing among member institutions while maintaining individual identities. The conversation addresses challenges facing higher education, including increasing closure rates and the importance of proactive strategies like mergers, acquisitions, and consolidations. Both McNaughton and Horowitz emphasize the necessity of early planning and shared vision, particularly involving faculty, for successful integration. They also touch on broader trends and challenges in higher education, such as increasing closures and the challenges boards face in adapting to the uniqueness of the business of higher education. They conclude with practical advice for institutions considering consolidation, focusing on partnership development, early financial assessment, and resource amplification to strengthen academic missions.   Key Discussion Points   The Community Solution Model: A Collaborative System Alternative to Traditional M&A: The Community Solution operates as a "system" where institutions collaborate rather than compete. This approach aims to optimize resources, share expertise, and improve student success. Quote: "The consolidation that operates as a system in which its institutions collaborate instead of competing, gain resources, share expertise, and optimize expenditures in the process." – Michael Horowitz System Integration: The system model integrates non-student facing operations like finance, technology, and marketing. This allows individual institutions to focus on academic endeavors. Quote: "All of that can be scaled. To better quality, for the same dollar... The uniqueness has to drive through the academics."– Michael Horowitz Maintaining Institutional Identity: Each college within the system retains its own accreditation, president, board, leadership, assets, and liabilities. The system consolidates operations, not the institutions themselves. Quote: "…each of our colleges keeps its own accreditation, president, board, leadership, their own assets and liabilities." – Michael Horowitz Trends in Higher Education and the Need for Consolidation Increasing Closures: The concerning trend of college closures, which have a significant negative impact on students and communities. Clayton Christensen's prediction of closures is revisited and said to be possibly understated. Quote: " The closure rate is accelerating. Last year there were 80 closures total, including 16 nonprofits." – Drumm McNaughton Mature and Declining Market: The higher education market is described as mature with overcapacity and declining student populations. The need for a new strategy to remain viable is clear. Boards Waiting Too Long: Many college boards are hesitant to act proactively and address financial or enrollment trends until it is too late. Relying on 'hope' is not an effective strategy. AI Prediction: AI models could accurately predict most college closures based on historical data, showing that many of these closures are foreseeable. The Benefits of a System Approach Resource Amplification: Consolidation of back-end services leads to cost savings that can be reinvested into academic programs. The system aims to "amplify" resources, not just save money. Scalability and Efficiency: Shared resources and centralized functions create economies of scale and improve overall efficiency. Shared Talent and Ideas: The system fosters collaboration and the sharing of best practices among institutions and staff, resulting in shared knowledge. Quote: "...we're amplifying our brain power by coming together." –  Michael Horowitz Enhanced Faculty and Student Resources: The system provides faculty with resources like teaching and learning support and global engagement programs. Implementation and Integration Challenges Regulatory Process: Post-merger integration involves navigating a complex regulatory process that requires meticulous planning and execution and can take an extended amount of time. Project Management: Successful integration requires strong project management skills to coordinate the various tasks and stages. “The most valuable person that you have on your post-merger integration team is your project manager." – Dr. Drumm McNaughton. Faculty Buy-In: Obtaining faculty support and ensuring clear communication are crucial for a successful transition. Timeline: The process from initial discussion to full integration can be lengthy and can take up to three years. Consolidation Governance Structure Dual Board Structure: Each college retains its own board, which is deeply involved with the day-to-day operations, while a system board oversees the overall system mission, risk, and financial health. System Board Role: The system board provides guidance and support but does not interfere with the day-to-day operations of the colleges. This board looks at how the system works together. Shared Governance: Overlap between the two board structures allows for a shared understanding of institutional goals and needs. Future Plans at The Community Solution (TCS) New Facility in Chicago: The Community Solution is consolidating its system office and Chicago school into a new facility to increase collaboration and efficiency. This includes plans for a second medical school. Canadian Recruitment: The system is planning to establish a presence in Vancouver, Canada, to recruit more international students without needing to create duplicative offices. Global Perspective: The system sees the importance of global education and perspective in higher ed. Three Takeaways for Institution Presidents and Boards Considering Consolidation Seek Partnerships: Proactively explore potential collaborations with other colleges, universities, or community entities. Act Early & Study Financials: Have these conversations early, don't wait until urgency arises, and be very aware of financial and enrollment trends. Amplify Resources: Focus on amplifying resources through collaboration to strengthen both the academic mission and community impact. Wrapping Up This podcast provides valuable insights into an alternative model for higher education consolidation that prioritizes collaboration, resource optimization, and the preservation of institutional identity. The Community Solution's approach serves as an example for other institutions facing challenges in a changing higher education landscape. The conversation highlights the necessity of proactive decision-making and strategic planning. Read the transcript on our website at https://changinghighered.com/new-models-for-consolidation-in-higher-education/ #HigherEducation #HigherEducationConsolidation #HigherEducationPodcast   About Our Podcast Guest Michael Horowitz, Ph.D., is the founder and president of The Community Solution Education System, an integrated, nonprofit system of six colleges and universities that work collaboratively to increase student success and enhance community impact. Prior to founding The Community Solution, he served as president of The Chicago School for nearly a decade. Dr. Horowitz has more than 30 years of experience in higher education roles that include faculty member, program director, and dean. He holds a Ph.D. in Clinical Psychology from Northwestern University and a B.A. in Psychology from Columbia University. Connect with Michael Horowitz on LinkedIn →   About the Host Dr. Drumm McNaughton is the founder, CEO, and Principal Consultant at The Change Leader, Inc. A highly sought-after higher education consultant with 20+ years of experience, Dr. McNaughton works with leadership, management, and boards of both U.S. and international institutions. His expertise spans key areas, including accreditation, governance, strategic planning, presidential onboarding, mergers, acquisitions, and strategic alliances. Dr. McNaughton's approach combines a holistic methodology with a deep understanding of the contemporary and evolving challenges facing higher education institutions worldwide to ensure his clients succeed in their mission.

We review the past year, look to the interesting arrivals in 2025, contemplate the Tesla conundrum, and talk to EV conversion specialist Nick Cummins from ElectroGusto.

Liberty Dispatch ~ December 13, 2024In this episode of Liberty Dispatch, hosts Andrew DeBartolo and Matthew Hallick break down recent Canadian news from a Christian perspective. Segment 1 - News Brief:“Explosive Truth About Origin of COVID-19 to Emerge” | The Telegraph: https://www.telegraph.co.uk/us/comment/2024/12/06/explosive-truth-about-origin-covid-19-emerge;“Breaking: Canadian Pro-Life Heroine Linda Gibbons Acquitted of Criminal Mischief” | LifeSiteNews: https://www.lifesitenews.com/news/breaking-canadian-pro-life-heroine-linda-gibbons-acquitted-of-criminal-mischief;“Canadians Approve of Trump Over Trudeau, Think U.S. Is Heading in Right Direction: Poll” | The Post Millennial: https://thepostmillennial.com/canadians-approve-of-trump-over-trudeau-think-us-is-heading-in-right-direction-poll;“Governor, State, Canada: Trump’s Dig at Trudeau” | National Post: https://nationalpost.com/news/politics/governor-state-canada-trump-dig-at-trudeau;“Court Will Review Conviction and Punishment of Constable Michael Brisco on Wednesday, December 11” | JCCF: https://www.jccf.ca/court-will-review-conviction-and-punishment-of-constable-michael-brisco-on-wednesday-december-11;“Canadian Military Survey on Extremism Asked Soldiers If They’ve Worn ‘Make Canada Great Again’ Hats” | LifeSiteNews: https://www.lifesitenews.com/news/canadian-military-survey-on-extremism-asked-soldiers-if-theyve-worn-make-canada-great-again-hats; Segment 2 - Another Liberal Gun Grab:“Trudeau Liberals Expand Gun Grab, Adding 324 New Models to Ban List” | Toronto Sun: https://torontosun.com/news/national/trudeau-liberals-expand-gun-grab-adding-324-new-models-to-ban-list;“Government of Canada Extends List of Prohibited Assault-Style Firearms and Moves Forward on Regulatory Changes to Strengthen Gun Control” | Government of Canada: https://www.canada.ca/en/public-safety-canada/news/2024/12/government-of-canada-extends-list-of-prohibited-assault-style-firearms-and-moves-forward-on-regulatory-changes-to-strengthen-gun-control.html; Segment 3 - Quebec to ban public prayer:“New Law Bans Religious Instruction in Quebec Schools, Aims to Strengthen Secularism” | CBC News: https://www.cbc.ca/news/canada/montreal/religion-in-schools-new-law-quebec-1.7403485;"Demand Letter Sent to Premier Legault Following Remarks About Banning Public Prayer” | Justice Centre for Constitutional Freedoms: https://www.jccf.ca/demand-letter-sent-to-premier-legault-following-remarks-about-banning-public-prayer; SUPPORT OUR LEGAL ADVOCACY - Help us defend Canadians' God-given rights and liberties: https://libertycoalitioncanada.com/donate/; https://libertycoalitioncanada.com/liberty-defense-fund/our-legal-strategy/;SHOW SPONSORS:Join Red Balloon Today!: https://www.redballoon.work/lcc; Invest with Rocklinc: info@rocklinc.com or call them at 905-631-546; Diversify Your Money with Bull Bitcoin: https://mission.bullbitcoin.com/lcc;BarterPay: https://barterpay.ca/; Barter It: https://vip.barterit.ca/launch; Carpe Fide - "Seize the Faith": Store: https://carpe-fide.myshopify.com/, use Promo Code LCC10 for 10% off (US Store Only), or shop Canadian @ https://canadacarpefide.myshopify.com/ | Podcast: https://www.carpefide.com/episodes;Get freedom from Censorious CRMs by singing up for SalesNexus: https://www.salesnexus.com/;Ready to own your own business? Join the Pro Fleet Care team today!: https://profleetcare.com/;Sick of Mainstream Media Lies? Help Support Independent Media! DONATE TO LCC TODAY!: https://libertycoalitioncanada.com/donate/ Please Support us in bringing you honest, truthful reporting and analysis from a Christian perspective.SUBSCRIBE TO OUR SHOWS/CHANNELS:LIBERTY DISPATCH PODCAST: https://libertydispatch.podbean.com; https://rumble.com/LDshow; OPEN MIKE WITH MICHAEL THIESSEN: https://openmikewithmichaelthiessen.podbean.com; https://rumble.com/openmike;THE OTHER CLUB: https://rumble.com/c/c-2541984; THE LIBERTY LOUNGE WITH TIM TYSOE: https://rumble.com/LLwTT;CONTACT US:Questions/comments about podcasts/news/analysis: mailbag@libertycoalitioncanada.com;Questions/comments about donations: give@libertycoalitioncanada.com;Questions/comments that are church-related: churches@libertycoalitioncanada.com;General Inquiries: info@libertycoalitioncanada.com. STAY UP-TO-DATE ON ALL THINGS LCC:Gab: https://gab.com/libertycoalitioncanada Telegram: https://t.me/libertycoalitioncanadanews Instagram: https://instagram.com/libertycoalitioncanada Facebook: https://facebook.com/LibertyCoalitionCanada Twitter: @LibertyCCanada - https://twitter.com/LibertyCCanada Rumble: https://rumble.com/user/LibertyCoalitionCanada YouTube: https://www.youtube.com/@liberty4canada - WE GOT CANCELLED AGAIN!!! Please LIKE, SUBSCRIBE, RATE, & REVIEW, and SHARE it with others!

Liberty Dispatch ~ December 13, 2024 In this episode of Liberty Dispatch, hosts Andrew DeBartolo and Matthew Hallick break down recent Canadian news from a Christian perspective. Segment 1 - News Brief: “Explosive Truth About Origin of COVID-19 to Emerge” | The Telegraph: https://www.telegraph.co.uk/us/comment/2024/12/06/explosive-truth-about-origin-covid-19-emerge; “Breaking: Canadian Pro-Life Heroine Linda Gibbons Acquitted of Criminal Mischief” | LifeSiteNews: https://www.lifesitenews.com/news/breaking-canadian-pro-life-heroine-linda-gibbons-acquitted-of-criminal-mischief; “Canadians Approve of Trump Over Trudeau, Think U.S. Is Heading in Right Direction: Poll” | The Post Millennial: https://thepostmillennial.com/canadians-approve-of-trump-over-trudeau-think-us-is-heading-in-right-direction-poll; “Governor, State, Canada: Trump's Dig at Trudeau” | National Post: https://nationalpost.com/news/politics/governor-state-canada-trump-dig-at-trudeau; “Court Will Review Conviction and Punishment of Constable Michael Brisco on Wednesday, December 11” | JCCF: https://www.jccf.ca/court-will-review-conviction-and-punishment-of-constable-michael-brisco-on-wednesday-december-11; “Canadian Military Survey on Extremism Asked Soldiers If They've Worn ‘Make Canada Great Again' Hats” | LifeSiteNews: https://www.lifesitenews.com/news/canadian-military-survey-on-extremism-asked-soldiers-if-theyve-worn-make-canada-great-again-hats;  Segment 2 - Another Liberal Gun Grab: “Trudeau Liberals Expand Gun Grab, Adding 324 New Models to Ban List” | Toronto Sun: https://torontosun.com/news/national/trudeau-liberals-expand-gun-grab-adding-324-new-models-to-ban-list; “Government of Canada Extends List of Prohibited Assault-Style Firearms and Moves Forward on Regulatory Changes to Strengthen Gun Control” | Government of Canada: https://www.canada.ca/en/public-safety-canada/news/2024/12/government-of-canada-extends-list-of-prohibited-assault-style-firearms-and-moves-forward-on-regulatory-changes-to-strengthen-gun-control.html; Segment 3 - Quebec to ban public prayer: “New Law Bans Religious Instruction in Quebec Schools, Aims to Strengthen Secularism” | CBC News: https://www.cbc.ca/news/canada/montreal/religion-in-schools-new-law-quebec-1.7403485; "Demand Letter Sent to Premier Legault Following Remarks About Banning Public Prayer” | Justice Centre for Constitutional Freedoms: https://www.jccf.ca/demand-letter-sent-to-premier-legault-following-remarks-about-banning-public-prayer; SUPPORT OUR LEGAL ADVOCACY - Help us defend Canadians' God-given rights and liberties: https://libertycoalitioncanada.com/donate/; https://libertycoalitioncanada.com/liberty-defense-fund/our-legal-strategy/; SHOW SPONSORS: Join Red Balloon Today!: https://www.redballoon.work/lcc;  Invest with Rocklinc: info@rocklinc.com or call them at 905-631-546;  Diversify Your Money with Bull Bitcoin: https://mission.bullbitcoin.com/lcc; BarterPay: https://barterpay.ca/;  Barter It: https://vip.barterit.ca/launch; Carpe Fide - "Seize the Faith": Store: https://carpe-fide.myshopify.com/, use Promo Code LCC10 for 10% off (US Store Only), or shop Canadian @ https://canadacarpefide.myshopify.com/ | Podcast: https://www.carpefide.com/episodes; Get freedom from Censorious CRMs by singing up for SalesNexus: https://www.salesnexus.com/; Ready to own your own business? Join the Pro Fleet Care team today!: https://profleetcare.com/; Sick of Mainstream Media Lies? Help Support Independent Media! DONATE TO LCC TODAY!: https://libertycoalitioncanada.com/donate/   Please Support us in bringing you honest, truthful reporting and analysis from a Christian perspective. SUBSCRIBE TO OUR SHOWS/CHANNELS: LIBERTY DISPATCH PODCAST: https://libertydispatch.podbean.com; https://rumble.com/LDshow;  OPEN MIKE WITH MICHAEL THIESSEN: https://openmikewithmichaelthiessen.podbean.com; https://rumble.com/openmike; THE OTHER CLUB: https://rumble.com/c/c-2541984;  THE LIBERTY LOUNGE WITH TIM TYSOE: https://rumble.com/LLwTT; CONTACT US: Questions/comments about podcasts/news/analysis: mailbag@libertycoalitioncanada.com; Questions/comments about donations: give@libertycoalitioncanada.com; Questions/comments that are church-related: churches@libertycoalitioncanada.com; General Inquiries: info@libertycoalitioncanada.com.  STAY UP-TO-DATE ON ALL THINGS LCC: Gab: https://gab.com/libertycoalitioncanada  Telegram: https://t.me/libertycoalitioncanadanews  Instagram: https://instagram.com/libertycoalitioncanada  Facebook: https://facebook.com/LibertyCoalitionCanada  Twitter: @LibertyCCanada - https://twitter.com/LibertyCCanada  Rumble: https://rumble.com/user/LibertyCoalitionCanada  YouTube: https://www.youtube.com/@liberty4canada - WE GOT CANCELLED AGAIN!!! Please LIKE, SUBSCRIBE, RATE, & REVIEW, and SHARE it with others!

Liberty Dispatch ~ December 13, 2024In this episode of Liberty Dispatch, hosts Andrew DeBartolo and Matthew Hallick break down recent Canadian news from a Christian perspective. Segment 1 - News Brief:“Explosive Truth About Origin of COVID-19 to Emerge” | The Telegraph: https://www.telegraph.co.uk/us/comment/2024/12/06/explosive-truth-about-origin-covid-19-emerge;“Breaking: Canadian Pro-Life Heroine Linda Gibbons Acquitted of Criminal Mischief” | LifeSiteNews: https://www.lifesitenews.com/news/breaking-canadian-pro-life-heroine-linda-gibbons-acquitted-of-criminal-mischief;“Canadians Approve of Trump Over Trudeau, Think U.S. Is Heading in Right Direction: Poll” | The Post Millennial: https://thepostmillennial.com/canadians-approve-of-trump-over-trudeau-think-us-is-heading-in-right-direction-poll;“Governor, State, Canada: Trump’s Dig at Trudeau” | National Post: https://nationalpost.com/news/politics/governor-state-canada-trump-dig-at-trudeau;“Court Will Review Conviction and Punishment of Constable Michael Brisco on Wednesday, December 11” | JCCF: https://www.jccf.ca/court-will-review-conviction-and-punishment-of-constable-michael-brisco-on-wednesday-december-11;“Canadian Military Survey on Extremism Asked Soldiers If They’ve Worn ‘Make Canada Great Again’ Hats” | LifeSiteNews: https://www.lifesitenews.com/news/canadian-military-survey-on-extremism-asked-soldiers-if-theyve-worn-make-canada-great-again-hats; Segment 2 - Another Liberal Gun Grab:“Trudeau Liberals Expand Gun Grab, Adding 324 New Models to Ban List” | Toronto Sun: https://torontosun.com/news/national/trudeau-liberals-expand-gun-grab-adding-324-new-models-to-ban-list;“Government of Canada Extends List of Prohibited Assault-Style Firearms and Moves Forward on Regulatory Changes to Strengthen Gun Control” | Government of Canada: https://www.canada.ca/en/public-safety-canada/news/2024/12/government-of-canada-extends-list-of-prohibited-assault-style-firearms-and-moves-forward-on-regulatory-changes-to-strengthen-gun-control.html; Segment 3 - Quebec to ban public prayer:“New Law Bans Religious Instruction in Quebec Schools, Aims to Strengthen Secularism” | CBC News: https://www.cbc.ca/news/canada/montreal/religion-in-schools-new-law-quebec-1.7403485;"Demand Letter Sent to Premier Legault Following Remarks About Banning Public Prayer” | Justice Centre for Constitutional Freedoms: https://www.jccf.ca/demand-letter-sent-to-premier-legault-following-remarks-about-banning-public-prayer; SUPPORT OUR LEGAL ADVOCACY - Help us defend Canadians' God-given rights and liberties: https://libertycoalitioncanada.com/donate/; https://libertycoalitioncanada.com/liberty-defense-fund/our-legal-strategy/;SHOW SPONSORS:Join Red Balloon Today!: https://www.redballoon.work/lcc; Invest with Rocklinc: info@rocklinc.com or call them at 905-631-546; Diversify Your Money with Bull Bitcoin: https://mission.bullbitcoin.com/lcc;BarterPay: https://barterpay.ca/; Barter It: https://vip.barterit.ca/launch; Carpe Fide - "Seize the Faith": Store: https://carpe-fide.myshopify.com/, use Promo Code LCC10 for 10% off (US Store Only), or shop Canadian @ https://canadacarpefide.myshopify.com/ | Podcast: https://www.carpefide.com/episodes;Get freedom from Censorious CRMs by singing up for SalesNexus: https://www.salesnexus.com/;Ready to own your own business? Join the Pro Fleet Care team today!: https://profleetcare.com/;Sick of Mainstream Media Lies? Help Support Independent Media! DONATE TO LCC TODAY!: https://libertycoalitioncanada.com/donate/ Please Support us in bringing you honest, truthful reporting and analysis from a Christian perspective.SUBSCRIBE TO OUR SHOWS/CHANNELS:LIBERTY DISPATCH PODCAST: https://libertydispatch.podbean.com; https://rumble.com/LDshow; OPEN MIKE WITH MICHAEL THIESSEN: https://openmikewithmichaelthiessen.podbean.com; https://rumble.com/openmike;THE OTHER CLUB: https://rumble.com/c/c-2541984; THE LIBERTY LOUNGE WITH TIM TYSOE: https://rumble.com/LLwTT;CONTACT US:Questions/comments about podcasts/news/analysis: mailbag@libertycoalitioncanada.com;Questions/comments about donations: give@libertycoalitioncanada.com;Questions/comments that are church-related: churches@libertycoalitioncanada.com;General Inquiries: info@libertycoalitioncanada.com. STAY UP-TO-DATE ON ALL THINGS LCC:Gab: https://gab.com/libertycoalitioncanada Telegram: https://t.me/libertycoalitioncanadanews Instagram: https://instagram.com/libertycoalitioncanada Facebook: https://facebook.com/LibertyCoalitionCanada Twitter: @LibertyCCanada - https://twitter.com/LibertyCCanada Rumble: https://rumble.com/user/LibertyCoalitionCanada YouTube: https://www.youtube.com/@liberty4canada - WE GOT CANCELLED AGAIN!!! Please LIKE, SUBSCRIBE, RATE, & REVIEW, and SHARE it with others!

Are we living through the fastest AI innovation sprint in history?This week, the AI world was set ablaze with groundbreaking releases from OpenAI, Google, and Amazon, among others. From OpenAI's ambitious “12 Days of OpenAI” campaign to Google's jaw-dropping Veo video generation capabilities, and Amazon unveiling the Nova series, innovation is moving at lightning speed.What do these advancements mean for businesses, creators, and technology leaders? How will the introduction of multimodal agents, advanced reasoning tools, and video AI redefine the future of work and creativity? This episode dives into the transformative announcements and their implications.If you're looking to stay ahead of the curve, you can't miss this episode: In this session, you'll discover:OpenAI's O1 Pro model: what it is, why it matters, and how it's setting new benchmarks in STEM reasoning.Google's Veo: a 1080p video generation model designed to disrupt content creation.Amazon's Nova family: affordable and advanced AI models for text, images, and video.The rapid evolution of multi-agent systems and their potential to redefine enterprise operations.How OpenAI's new pricing tiers could shape access to advanced AI tools.Why video AI could soon surpass human-generated content in quality and speed.About Leveraging AI The Ultimate AI Course for Business People: https://multiplai.ai/ai-course/ YouTube Full Episodes: https://www.youtube.com/@Multiplai_AI/ Connect with Isar Meitis: https://www.linkedin.com/in/isarmeitis/ Free AI Consultation: https://multiplai.ai/book-a-call/ Join our Live Sessions, AI Hangouts and newsletter: https://services.multiplai.ai/events If you've enjoyed or benefited from some of the insights of this episode, leave us a five-star review on your favorite podcast platform, and let us know what you learned, found helpful, or liked most about this show!

The Empire are here - well previewed - we run through the initial release and other models you can use for WTOW from the Warhammer Championships preview. + Frydaal! and more Patreon Questions and Quizes

Two of our discourse besties from UAL's Fashion Media Practice & Criticism -- experiential designers Daniel Felstead and Jenn Leung -- join us to talk Janky Capitalism (the obvious falling-apart weirdness of the world while capital spins off farther and farther away from it, leaving us behind), Roblox, and neural media. You probably know their work from the iconic 'The Metaverse in Janky Capitalism' on Dis and its associated 'Literally No Place' and 'Always on My Mind' -- or from associated speaking / discourse production all over the internet (++ more on Jenn (link) and Daniel (link)).References from the pod include:Ruba Al-Sweel's awesome piece for SQD: 'Sandbox Semiotics' referenced in the intro.Jenn references artworld queen Anna Uddenberg (e.g. 'Continental Breakfast'), Harvard's GSD's Guide to Shopping, and Ian Bogost (whose critique of anthropomorphism in video games we really relate to).Daniel references Sam Cummins from Nymphet Alumni, a favorite podcast that everyone should already know and spend all their time listening to.Daniel references Catherine Malabou's concept of plasticity (throughout her work, typically referencing neuroscientific plasticisty, here used in its more generalized form).The second half of the episode spends some time with the theory of K. Allado-McDowell, specifically the concept of neural media. We could not recommend this episode of our other favorite podcast (New Models) more strongly.Roberto mentions Zachary Horton's 'Cosmic Zoom', which is our obsession atm.Ok enjoyyyy byee!

New Martin Guitar Models for fall, 2024. Martin has already released some great new guitars ahead of the official January NAMM show. OMC-10E, D-11E Rock the Vote, HG-28 O'ahu & 000-15E are just some of the new offerings already available at Martin Guitar in the fall of 2024. Sit back & relax as we get you up to speed on the newest Martin guitar models.

This week we review the new Teardrop putters. Teardrop has released 3 new models that feature great milling and tons of technology. The blade is traditional looking while the mallets feature some of the latest trends.

AM Best TV hosted a panel discussion about evolving technology that's proven to be innovative, revolutionary and successful in the industry.

In this episode of the *HyperFast Agent Show*, Dan Lesniak explores the traditional real estate team model and how recent market shifts have challenged its profitability. He breaks down the rising costs of leads and reduced transaction volume, which have put pressure on large teams with high overhead. Dan introduces new team models that prioritize agent training, lead generation, and branding autonomy, which are becoming increasingly popular. These innovative structures allow for lower overhead, increased agent retention, and greater flexibility, offering team leaders a new path forward in today's market.   Want to partner with Billion Dollar Agents? Keri Shull and Dan Lesniak are top sponsoring agents at eXp realty. To learn more about partnering with them at eXp realty text Dan at 703-638-4393.   Bullet Points of Discussion: - How the traditional real estate team model is being challenged by reduced sales and rising lead costs. - The benefits of empowering agents to generate their own leads and build personal brands. - The role of cloud-based brokerages and revenue share in supporting newer, more flexible team models.   Notable Quote:     "Empowering agents to generate their own leads and build their own business is the key to minimizing overhead and maximizing retention." – Dan Lesniak WANT TO GET ACCESS TO ALL OUR HYPERFAST AGENT COURSES FOR A $1 TRIAL? Click here for a trial membership in the Our Inner Circle. KEEP UP WITH US HERE Website: https://hyperfastagent.com  Instagram: https://www.instagram.com/HyperFastAgent/  Facebook: https://www.facebook.com/HyperFastAgent/ Twitter: https://www.twitter.com/hyperfastagent  LinkedIn: https://www.linkedin.com/company/hyperlocal-hyperfast/    OUR OTHER EXCLUSIVE YOUTUBE CHANNELS  The Keri Shull Team: https://youtube.com/kerishullteam  Dan Lesniak - https://www.youtube.com/danlesniak    THE BOOK THAT HELPED 10K+ REALTORS https://amzn.to/2Mkm9Jp   GET DAN'S BEST SELLING BOOK FREE https://bit.ly/3dbiH3q    INTERESTED IN TAKING YOUR REAL ESTATE BUSINESS TO THE NEXT LEVEL?  https://bit.ly/3eLG97Z

This month, an update from "Mr. Angler Quest", Brad Dupuie. Brad talks about the recent AQ dealer meeting and a new lineup of smaller panfish models designed for inland lakes. Brad discusses reaction to those new models and the updated Family Fish tritoon for big water fishing. The hard core angler turned boat designer also describes the schedule for getting these new boats out to dealers and customers.    

In the second of two episodes covering the IPA Effectiveness Conference, WARC's Anna Hamill speaks to Tom Roach (Jellyfish) about share of model, Leo Rayman (EdenLab) and Jo McClintock (Trainline) talk about demand switching for environmental impact, and ITV's Sameer Modha and Kate Waters discuss their research on the present value of future spend.Stay up-to-date with the latest marketing and advertising news with our free daily newsletter.

When I think of digital biology, I think of Patrick Hsu—he's the prototype, a rarified talent in both life and computer science, who recently led the team that discovered bridge RNAs, what may be considered CRISPR 3.0 for genome editing, and is building new generative A.I. models for life science. You might call them LLLMs-large language of life models. He is Co-Founder and a Core Investigator of the Arc Institute and Assistant Professor of Bioengineering and Deb Faculty Fellow at the University of California, Berkeley.Above is a brief snippet of our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Here's the transcript with links to the audio and external links to relevant papers and things we discussed.Eric Topol (00:06):Well hello, it's Eric Topol with Ground Truths and I'm really delighted to have with me today Patrick Hsu. Patrick is a co-founder and core investigator at the Arc Institute and he is also on the faculty at the University of California Berkeley. And he has been lighting things up in the world of genome editing and AI and we have a lot to talk about. So welcome, Patrick.Patrick Hsu (00:29):Thanks so much. I'm looking forward to it. Appreciate you having me on, Eric.The Arc InstituteEric Topol (00:33):Well, the first thing I'd like to get into, because you're into so many important things, but one that stands out of course is this Arc Institute with Patrick Collison who I guess if you can tell us a bit about how you two young guys got to meet and developed something that's really quite unique that I think brings together investigators at Stanford, UCSF, and Berkeley. Is that right? So maybe you can give us the skinny about you and Patrick and how all this got going.Patrick Hsu (01:05):Yeah, sure. That sounds great. So we started Arc with Patrick C and with Silvana Konermann, a longtime colleague and chemistry faculty at Stanford about three years ago now, though we've been physically operational just over two years and we're an independent research institute working at the interface of biomedical science and machine learning. And we have a few different aspects of our model, but our overall mission is to understand and treat complex human diseases. And we have three pillars to our model. We have this PI driven side of the house where we centrally fund our investigators so that they don't have to write grants and work on their very best ideas. We have a technical staff side of the house more like you'd see in a frontier AI lab or in biotech industry where we have professional teams of R&D scientists working cross-functionally on higher level organizational wide goals that we call our institute initiatives.(02:05):One focused on Alzheimer's disease experimentally and one that we call a virtual cell initiative to simulate human biology with AI foundation models. And our third pillar over time is to have things not just end up as academic papers, but really get things out into the real world as products or as medicines that can actually help patients on the translational side. And so, we thought that some really important scientific programs could be unlocked by enabling new organizational models and we are experimenting at the institutional scale with how we can better organize and incentivize and support scientists to reach these long-term capability breakthroughs.Patrick, Patrick and SilvanaEric Topol (02:52):So the two Patrick's. How did you, one Patrick I guess is a multi-billionaire from Stripe and then there's you who I suspect maybe not quite as wealthy as the other Patrick, how did you guys come together to do this extraordinary thing?Patrick Hsu (03:08):Yeah, no, science is certainly expensive. I met Patrick originally through Silvana actually. They actually met, so funny trivia, all three Arc founders did high school science together. Patrick and Silvana originally met in the European version of the European Young Scientist competition in high school. And Silvana and I met during our PhDs in her case at MIT and I was at Harvard, but we met at the Broad Institute sort of also a collaborative Harvard, MIT and Harvard hospitals Institute based in Kendall Square. And so, we sort of in various pairwise combinations known each other for decades and worked together for decades and have all collectively been really excited about science and technology and its potential to accelerate societal progress. Yet we also felt in our own ways that despite a lot of the tremendous progress, the structures in which we do this work, fund it, incentivize it and roll it out into the real world, seems like it's really possible that we'll undershoot that potential. And if you take 15 years ago, we didn't have the modern transformer that launched the current AI revolution, CRISPR technology, single-cell, mRNA technology or broadly addressable LNPs. That's a tremendous amount of technologies have developed in the next 15 years. We think there's a real unique opportunity for new institutes in the 2020s to take advantage of all of these breakthroughs and the new ones that are coming to continue to accelerate biological progress but do so in a way that's fast and flexible and really focused.Eric Topol (04:58):Yeah, I did want to talk with you a bit. First of all before I get to the next related topic, I get a kick out of you saying you've worked or known each other for decades because I think you're only in your early thirties. Is that right?Patrick Hsu (05:14):I was lucky to get an early start. I first started doing research at the local university when I was 14 actually, and I was homeschooled actually until college. And so, one of the funny things that you got to do when you're homeschooled is well, you could do whatever you want. And in my case that was work in the lab. And so, I actually worked basically full time as an intern volunteer, cut my teeth in single cell patch clamp, molecular biology, protein biochemistry, two photon and focal imaging and kind of spiraled from there. I loved the lab, I loved doing bench work. It was much more exciting to me than programming computers, which was what I was doing at the time. And I think these sort of two loves have kind of brought me and us to where we are today.Eric Topol (06:07):Before you got to Berkeley and Arc, I know you were at Broad Institute, but did you also pick up formal training in computer science and AI or is that something that was just part of the flow?Patrick Hsu (06:24):So I grew up coding. I used to work through problems sets before dinner growing up. And so, it's just something that you kind of learn natively just like learning French or Mandarin.New Models of Funding Life ScienceEric Topol (06:42):That's what I figured. Okay. Now this model of Arc Institute came along in a kind of similar timeframe as the Arena BioWorks in Boston, where some of the faculty left to go to Arena like my friend Stuart Schreiber and many others. And then of course Priscilla and Mark formed the Chan Zuckerberg Institute and its biohub and its support. So can you contrast for one, these three different models because they're both very different than of course the traditional NIH pathway, how Arc is similar or different to the others, and obviously the goal here is accelerating things that are going to really make a difference.Patrick Hsu (07:26):Yeah, the first thing I would say is zooming out. There have been lots of efforts to experiment with how we do science, the practice of science itself. And in fact, I've recently been reading this book, the Demon Under the Microscope about the history of infectious disease, and it talks about how in the 1910s through the 1930s, these German industrial dye manufacturing companies like Bayer and BASF actually launched what became essentially an early model for industrial scale science, where they were trying to develop Prontosil, Salvarsan and some of these early anti-infectives that targeted streptococcus. And these were some of the major breakthroughs that led to huge medical advances on tackling infectious disease compared to the more academic university bound model. So these trends of industrial versus academic labs and different structures to optimize breakthroughs and applications has been a through current throughout international science for the last century.(08:38):And so, the way that we do research today, and that's some of our core tenets at Arc is basically it hasn't always been this way. It doesn't need to necessarily be this way. And so, I think organizational experiments should really matter. And so, there's CZI, Altos, Arena, Calico, a variety of other organizational experiments and similarly we had MRC and Bell Labs and Xerox PARCS, NIBRT, GNF, Google Research, and so on. And so, I think there are lots of different ways that you can organize folks. I think at a high level you can think about ways that you can play with for-profit versus nonprofit structures. Whether you want to be a completely independent organization or if you want to be partnered with universities. If you want to be doing application driven science or really blue sky curiosity driven work. And I think also thinking through internally the types of expertise that you bring together.(09:42):You can think of it like a cancer institute maybe as a very vertically integrated model. You have folks working on all kinds of different areas surrounding oncology or immunotherapy and you might call that the Tower of Babel model. The other way that folks have built institutes, you might call the lily pad model where you have coverage of as many areas of biomedical research as possible. Places like the Whitehead or Salk, it will be very broad. You'll have planned epigenetics, folks looking at RNA structural biology, people studying yeast cell cycle, folks doing in vivo melanoma models. It's very broad and I think what we try to do at Arc is think about a model that you might liken more to overlapping Viking shields where there's sort of five core areas that we're deeply investing in, in genetics and genomics, computation, neuroscience, immunology and chemical biology. Now we really think of these as five areas that are maybe the minimal critical mass that you would need to make a dent on something as complicated as complex human diseases. It's certainly not the only thing that you need, but we needed a critical mass of investigators working at least in these areas.Eric Topol (11:05):Well, yeah, and they really converge on where the hottest advances are being made these days. Now can you work at Arc Institute without being one of these three universities or is it really that you maintain your faculty and your part of this other entity?Patrick Hsu (11:24):So we have a few elements to even just the academic side of the house. We have our core investigators. I'm one of them, where we have dually appointed faculty who retain their latter rank or tenured appointment in their home department, but their labs are physically cited at the Arc headquarters where we built out a lab in Stanford Research Park in Palo Alto. And so, folks move their labs there. They continue to train graduate students based on whatever graduate programs they're formally affiliated with through their university affiliation. And so, we have nearly 40 PhD students across our labs that are training on site every day.(12:03):So in addition to our core investigators, we also have what we call our innovation investigators, which is more of a grant program to faculty at our partner universities. They receive unrestricted funding from us to seed a new project or accelerate an existing area in their group and their labs stay at their home campus and they just get that funding to augment their work. The third way is our technical staff model where folks basically just come work at Arc and many of them also are establishing their own research groups focusing on technology R&D areas. And so, we have five of those technology centers working in molecular engineering, multi-omics, complex cellular models, in vivo models, and in machine learning.Discovery of Bridge RNAsEric Topol (12:54):Yeah, that's a great structure. In fact, just a few months ago, Patrick Collison, the other Patrick came to Stanford HAI where I'm on the board and you've summarized it really well and it's very different than the other models and other entities, companies included that you mentioned. It's really very impressive. Now speaking of impressive on June 26, this past few months ago, which incidentally is coincident with the draft genome in the year 2000, the human sequence. You and your colleagues, perhaps the most impressive jump in terms of an Arc Institute contribution published two papers back-to-back in Nature about bridge RNA: [Bridge RNAs direct programmable recombination of target and donor DNA] and [Structural mechanism of bridge RNA-guided recombination.] And before I get you to describe this breakthrough in genome editing, some would call it genome editing 3.0 or CRISPR 3.0, whatever. But what we have today in the clinic with the approval of CRISPR 1.0 for sickle cell and thalassemia is actually quite crude. I think most people will know it's just a double stranded DNA cleavage with all sorts of issues about repair and it's not very precise. And so, CRISPR 2.0 is supposed to be represented by David Liu's contributions and his efforts at Broad like prime and base editing and then comes yours. So maybe you can tell us about it and how it is has to be viewed as quite an important advance.Patrick Hsu (14:39):The first thing I would say before CRISPR, is that we had RNA interference. And so, even before this modern genome editing revolution with programmable CRISPRs, we had this technology that had a lot of the core selling points as well. Any target will now become druggable to us. We simply need to reprogram a guide RNA and we can get genetic access to things that are intracellular. And I think both the discovery of RNA interference by Craig Mello and Andy Fire or the invention or discovery of programmable CRISPR technologies, both depend on the same fundamental biological mechanism. These non-coding guide RNAs that are essentially a short RNA search string that you can easily reprogram to retarget a desired enzyme function, and natively both RNAi and CRISPR are molecular scissors. Their RNA or DNA nucleases that can be reprogrammed to different regions of the genome or the transcriptome to make a cut.(15:48):And as bioengineers, we have come up with all kinds of creative ways to leverage the ability to make site specific cuts to do all kinds of incredible things including genome editing or beyond transcriptional up or down regulation, molecular imaging and so on and so forth. And so, the first thing that we started thinking about in our lab was, why would mother nature have stopped only RNAi and CRISPR? There probably are lots of other non-coding RNAs out there that might be able to be programmable and if they did exist, they probably also do more complicated and interesting things than just guide a molecular scissors. So that was sort of the first core kind of intuition that we had. The second intuition that we had on the technology side, I was just wearing my biology hat, I'll put on my technology hat, is the thing that we call genome editing today hardly involves the genome.(16:50):It's really you're making a cut to change an individual base or an individual gene or locus. So really you're doing small scale single locus editing, so you might call it gene level or locus level cuts. And what you really want to be able to do is do things at the genome scale at 100 kb, a megabase at the chromosome scale. And I think that's where I think the field will inevitably go if you follow the technology curves of longer and longer range gene sequencing, longer and longer range gene synthesis, and then longer and longer range gene editing. And so, what would that look like? And we started thinking, could there be essentially recombination technologies that allow you to do cut and paste in a single step. Now, the reason for that is the way that we do gene editing today involves a cut and then a multi-step process of cellular DNA repair that resolves the cut to make the exertion or the error prone deletion or the modification that ends up happening.(17:59):And so, it's very complicated and whether that's nucleases or base or prime editing, you're all generally limited to the small-scale single locus changes. However, there are natural mechanisms that have solved this cut and paste problem, right? There are these viruses or bacterial versions of viruses known as phage that have generally been trying to exert their multi kilobase genomes into bacterial hosts and specialize throughout billions of years. So our core thought was, well, if there are these new non-coding RNAs, what kind of functions would we be excited about? Can we look in these mobile genetic elements, these so-called jumping genes for new mechanisms? They're incredibly widespread. Transposons are thought to be some of the most diverse enzyme mechanisms found in nature. And so, we started computationally by asking ourselves a very simple question. If a mobile element inserts itself into foreign DNA and it's able to somehow be programmable, presumably the inside or something encoded in the inside of the element is predictive of some sequence on the outside of the element.(19:15):And so, that was the core insight we took, and we thought let's look across the boundaries of many different mobile genetic elements and we zoomed in on a particular sub family of these MGE known as insertion sequence (IS) elements which are the most autonomous minimal transposons. Normally transposons have all kinds of genes that they use to hitchhike around the genomic galaxy and endow the bacterial host with some fitness advantage like some ability to metabolize some copper and some host or some metal. And these IS elements have only the enzymes that they need to jump around. And if you identify the boundaries of these using modern computational methods, this is actually a really non-trivial problem. But if you solve that problem to figure out with nucleotide resolution where the element boundaries end and then you look for the open reading frame of the transposases enzyme inside of this element, you'll find that it's not just that coding sequence.(20:19):There are also these non-coding flanks inside of the element boundaries. And when we looked across the non-coding, the entire IS family tree, there are hundreds of these different types of elements. We found that this particular family IS110, had the longest non-coding ends of all IS elements. And we started doing experiments in the lab to try to figure out how these work. And what we found was that these elements are cut and paste elements, so they excise themselves into a circular form and paste themselves back in into a target site linearly. But the circularization of this element brings together two distal ends together, which brings together a -35 and a -10 box that create and reconstitute a canonical bacterial transcriptional promoter. This essentially is like plugging a plug into an electrical socket in the wall and it jacks up transcription. Now you would think this transcription would turn on the transposase enzyme so it can jump around more but it transcribes a non-coding RNA out of this non-coding end.(21:30):We're like, holy crap, are these RNAs actually involved in regulating the transposon? Now the boring answer would be, oh, it regulates the expression. It's like an antisense regulate or something. The exciting answer would be, oh, it's a new type of guide RNA and you found an RNA guided integrase. So we started zooming in bound dramatically on this and we undertook a covariation analysis where we were able to show that this cryptic non-coding RNA has a totally novel guide RNA structure, totally distinct from RNAi or CRISPR guide RNAs. And it had a target site that covaried with the target site of the element. And so we're like, oh wow, this could be a programmable transposase. The second thing that we found was even more surprising, there was a second region of complementarity in that same RNA that recognized the donor sequence, which is the circularized element itself. And so, this was the first example of a bispecific guide RNA, and also the first example of RNA guided self-recognition by a mobile genetic element.Eric Topol (22:39):It's pretty extraordinary because basically you did a systematic assessment of jumping genes or transposons and you found that they contain things that previously were not at all recognized. And then you have a way to program these to edit, change the genome without having to do any cuts or nicks, right?Patrick Hsu (23:05):Yeah. So what we showed in a test tube is when we took this, so-called bridge RNA, which we named because it bridges the target and donor together along with the recombinase enzyme. So the two component system, those are the only two things that you need. They're able to cut and paste DNA and recombine them in a test tube without any DNA repair, meaning that it's independent of cellular DNA repair and it does strand nicking, exchange, junction resolution and religation all in a single mechanism. So that's when we got super excited about its potential applications as bioengineering tool.Eric Topol (23:46):Yeah, it's pretty extraordinary. And have you already gone into in vivo assessment?Patrick Hsu (23:54):Yes, in our initial set of papers, what we showed is that these are programmable and functional or recombinases in a test tube and in bacterial cells. And by reprogramming the target and donor the right way, you can use these enzymes not just for insertion, but also for flipping and cutting out DNA. And so, we actually have in a single mechanism the ability to do bridge editing, if you will, for universal DNA recombination, insertion, excision or inversion, similar to what folks have been doing for decades with Cre recombinase, but with fully programmable recognition sequences. The work that we're doing now in the lab as you can imagine is to adapt these into robust tools for mammalian genome editing, including of course, human genomes. We're excited about this, we're making good progress. The CRISPR has had thousands of labs over the last 10, 15 years working on it to make these therapeutic level potency and selectivity. We're going to work and follow that same blueprint for getting bridge systems to get to that level of performance, but we're on the path and we're very optimistic for the future.Exemplar of Digital BiologyEric Topol (25:13):Yeah, I think it's quite extraordinary and it's a whole different look to what we've been seeing in the CRISPR era for over the past decade and how that's been advancing and getting more specific and less need for repair and being able to be more versatile. But this takes it to yet another dimension. Now, this brings me to the field that when I think of this term digital biology, I think of you and now our mutual acquaintance, Jensen Huang, who everybody knows now. Back some months ago, he wrote and said at a conference, “Where do I think the next amazing revolution is going to come? And this is going to be flat out one of the biggest ones ever. There's no question that digital biology is going to be it. For the first time in human history, biology has the opportunity to be engineering, not science.” So can you critique Jensen? Is he right? And tell us how you conceive the field of digital biology.Patrick Hsu (26:20):If you look at gene therapy today, the core concepts are actually remarkably simple. They're elegant. Of course, you're missing a broken gene, you need to put it back. And that can be curative. Very simple, powerful concept. However, for complex diseases where you don't have just a single gene that goes wrong, in many cases we actually have no idea what to do. And in fact, when you're trying to put in DNA, that's over more than a gene scale. We kind of very quickly run out of ideas. Is it a CAR and a cytokine, a CAR and a cytokine and another thing? And then we're kind of out of ideas. And so, we started thinking in the lab, how can we actually design genomes where it's not just let's reduce the genome into individual Lego blocks, iGem style with promoters and different genes that we just sort of shuffle the Lego blocks around, but actually use AI to design genome sequences.(27:29):So to do that, we thought we would have to first of all, train a model that can learn and decode the foreign language of biology and use that in order to design sequences. And so, we sort of have been training DNA foundation models and virtual cell models at Arc, sort of a major effort of ours where the first thing that we tried was to take a variance of transformer architecture that's used to train ChatGPT from OpenAI, but instead apply this to study the next DNA token, right? Now, the interesting thing about next token prediction in English is that you can actually learn a surprising amount of information by just predicting the next word. You can learn world knowledge is the capital of Azerbaijan, is it Baku or is it London, right? Or if you're walking around in the kitchen, then the next text is, I then left the kitchen or the bathroom, right?(28:33):Now you're learning about spatial reasoning, and so you can also learn translation obviously. And so similarly, I think predicting the next token or the next base and DNA can lead you to learn about molecular biochemistry, is the next amino acid residue, hydrophobic or hydrophilic. And it can teach you about the mechanics of some catalytic binding pocket or something. You can learn about a disease mutation. Is the next base, the sick linked base or the wild type base and so on and so forth. And what we found was that at massive scale, DNA foundation models learn about molecular function, not just at the DNA level, but also at the RNA and the protein. And indeed, we could use these to design molecular systems like CRISPR-Cas systems, where you have a protein and the guide RNA. It could also design new DNA transposons, and we could design sequences that look plausibly like real genomes, where we generate a megabase a million bases of continuous genome sequence. And it really looks and feels like it could be a blurry picture of something that you would actually sequence. This has been a wonderful collaboration with Brian Hie, a PI at Stanford and an Arc investigator, and we're really excited about what we've seen in this work because it promises the better performance with even more scale. And so, simply by scaling up these models, by adding in more compute, more training data or more powerful models, they're going to get sharper and sharper.New A.I. Models in Life ScienceEric Topol (30:25):Yeah. Well, this whole use of large language models for the language of life, whether it's the genome proteins and on and on, actually RNA and even cells has really taken root. And of course, this is really one of the foundations of that field of digital biology, which brings together generative AI, AI tools and trying to push forward our understanding in biology. And also, obviously what's been emphasized in drug discovery, perhaps it's been emphasized even too much because we still have a lot to learn about biology, but that gets me to these models. Like today, AlphaProteo was announced by DeepMind, as we all know, AlphaFold 1, 2, now 3. They were kind of precursors of being able to predict proteins from amino acid 3D structure. And that kind of took the field by a little bit like ChatGPT for life science, but now it's a new model all the time. So you've been working on various models and Arc Institute, how do you see this unfolding? Are we just going to have every aspect of the language of life being approached in all the different interactions? And this is going to help us get to a much more deep level of understanding.Patrick Hsu (31:56):I'll say two things. The first is a lot of models that you just described are what I would call task specific models. A model for de novo design of a binder, a model for protein structure prediction. And there are other models for protein fitness or for RNA structure prediction, et cetera, et cetera. And I think what we're going to move towards are more unifying models where there's different classes of models at different levels of scale. So we will have these atomic level models for looking at generative chemistry or ligand docking. We have models that can unify genomes and their molecules, and then we have models that can unify cells and tissues. And so, for example, if you took an H&E stain of some liver, there are folks building models where you can then predict what the single cell spatial transcriptome will look like of that model. And that's obviously operating at a very different level of abstraction than a de novo protein binder. But in the long run, all of these are going to get, I think unified. I think the reason why this is possible is that biology, unlike physics, actually has this unifying theory of evolution that runs across all of its length scales from atomic, molecular, cellular, organismal to entire ecosystem. And the promise of these models is no short then to make biology a predictive discipline.Patrick Hsu (33:37):In physics, the experimentalists win the big prizes for the theorists when they measure gravitational waves or whatever. But in biology, we're very practical people. You do something three times and do a T-test. And I think my prediction is we can actually gauge the success of these LLMs or whatever in biology by how much we respect theory in this field.The A.I. ScientistEric Topol (34:05):Yeah. Well, that's a really interesting perspective, an important perspective because the proliferation of models, which we're going to get into not just doing the things that you described, but also being able to be “pseudo” scientists, the so-called AI scientist. Maybe you could comment about that concept because that's been the idea that everything from the question that could be asked to the hypothesis and the experiment design and the analysis of data and then the feedback. So what is the role of the scientists, that seems to have been overplayed? And maybe you can put that in context.Patrick Hsu (34:48):So yeah, right now there's a lot of excitement that we can use AI agents not just to do software enterprise workflows, but to be a research assistant. And then over time, itself an autonomous research scientist that can read the literature, come up with an idea, maybe run a bunch of robots in the lab or do a bunch of computational analyses and then potentially even analyze data, conclude what is going on and actually write an entire paper. Now, I think the vision of this is compelling in the long term. I think the question is really about timescale. If you break down the scientific method into its constituent parts, like hypothesis generation, doing an experiment, analyzing experiment and iterating, we're clearly going to use AI of some kind at every single step of this cycle. I think different steps will require different levels of maturity. The way that I would liken this is just wet lab automation, folks have dreamed about having pipetting robots that just do their western blots and do their cell culture for them for generations.(36:01):But of course, today they don't actually really feel fundamentally different from the same ones that we had in the 90s, let's say. Right? And so, obviously they're getting better, but it seems to me one of the trends I'm very bullish about is the explosion of humanoid robots and robot foundation models that have a world model and a sense of physics and proportionate space loaded onto them. Within five years, we're going to have home robots that can fold your clothes, that can organize your kitchen and do all of this while you're sleeping, so you wake up to a clean home every day.Eric Topol (36:40):It's not going to be just Roomba anymore. There's going to be a lot more, but it isn't just the hardware, it's also the agents playing in software, right?Patrick Hsu (36:50):It's the integrated loop of the hardware and the software where the ability to make the same machine generally intelligent will make it adaptable to a broad array of tasks. Now, what I'm excited about is those generally intelligent humanoid robots coming into the lab, where instead of creating a centrifuge or a new type of pipetter that's optimized for your Beckman or Hamilton device, instead you just have robot arms that you snap onto the edge of the bench and then they just work alongside you. And I do think that's coming, although it'll take a lot of hardware and software and computer vision engineering to make that possible.A Sense of HumorEric Topol (37:32):Yeah, and I think also going back to originating the question, there still is quite a debate about the creativity and the lack of any simulation of AGI, whatever that means anymore. And so, the human in the loop part of this is obviously I think it's still of critical nature. Now, the other thing I learned about you is you have a great sense of humor, which is really important by the way. And recently, which is great that you're active on X or Twitter because that's one way we get to see what you're thinking on a day-to-day basis. But I think you put out a poll which was really quite provocative , and it was about, here's what it said, “do more people in the world *truly* understand transformers or health insurance?” And interestingly, you got 49% for transformers at 51% for health insurance. Can you tell us what you're thinking when you put that poll together? Because obviously a lot of people don't understand either of these.Patrick Hsu (38:44):I think the core question is, there are different ways of looking at the world, some of which are very bottom up and some of which are very top down. And one of the very surprising things about transformers is they're taking something that is in principle, an incredibly simple task, which is if you have a string of text, what is the next letter? And somehow at massive, massive scale, you can unlock something that looks an awful lot like reasoning, and you've got these emergent behaviors. Now the bottoms up theory of just the linear algebra that's going on in these models couldn't possibly really help us predict that we have these emerging capabilities. And I think similarly in healthcare, there's a literal set of parts that are operating in some complex way that at massive scale becomes this incredibly confusing and dynamic system for how we can actually incentivize how we make medicines, how we actually take care of people, and how we actually pay for any of this from an economic point of view. And so, I think it was, in some sense if transformers can actually be an explainable by just linear algebra equations, maybe there will be a way to decompose the seemingly incredibly confusing world of healthcare in order to actually build a better way forward.Computing Power and the GPU Arms RaceEric Topol (40:12):Yeah. Well that's great. Now the other thing I wanted to ask you about, we open source and the arms race of GPUs and this whole kind of idea is you touched on the need for coalescing a lot of these tools to exploit the synergy. But we have an issue because many academic labs like here at Scripps Research and so many others, including as I learned even at Stanford, have limited access to GPUs. So computing power of large language models is a problem. And then the models that exist today that can be adopted like Llama or others, and they're somewhat limited. And then we also have a movement towards trying to make things more open source, like for example, recently OpenCRISPR with Profluent Bio that is basically trying to use AI for CRISPR guides. And so, how do you deal with this arms race, computing power, open source, proprietary models that are not easily accessible without a lot of resources?Patrick Hsu (41:30):So the first thing I would say is, we are in the academic science sphere really unprepared for the level of resources that are required for doing this type of cutting edge computational work. There are top Stanford computer science professors or computational researchers who have a single GPU in their office, and that's actually what their whole lab runs off of.(41:58):The UC Berkeley campus, the grid runs on something like 12 megawatts of power and how are they going to build an on-premises GPU clusters, like a central question that can scale across the entire needs? And these are two of the top computer science universities in the world. And so, I think one of our kind of core beliefs at Arc is, as science both experimentally and computationally has gotten incredibly complex, not just in terms of conceptually, but also just the actual infrastructure and machines and know-how that you need to do things. We actually need to essentially support this. So we have a private GPU cloud that we use to train our models, and we have access to significantly large clusters for large burst kind of train outs as necessary. And I think infrastructurally for running genomics experiments or doing scalable brain organoid screens, right, we're also building out the infrastructure to support that experimentally.Eric Topol (43:01):Yeah, no, I think this is one of the advantages of the new model like the Arc Institute because not many centers have that type of plasticity with access to computing power when needed. So that's where a brilliant mind you and the Arc Institute together makes for a formidable recipe for future advances and of course building on the ones you've already accomplished.The Primacy of Human TalentPatrick Hsu (43:35):I would just say, my main skill, if I have one, is to recruit really, really smart people. And so, everything that you're seeing and hearing about is the work of unbelievable colleagues who are curious, passionate, and incredible scientists.Eric Topol (43:53):But it also takes the person who can judge those who are in that category set as a role model. And you're certainly doing that. I guess just in closing, I mean, it's just such a delight to get to meet you here and kind of get your thoughts on what is the hottest thing in life science without question, which brings together the fields of AI and what's going on, not just obviously in genome editing, but this digital biology era that we're still in the early phases of, I mean, I think you could say that it's just going to continue to accelerate the exponential curve. We're still kind of on the bottom of that, I would imagine where we're headed. Any other things that you want to bring up that I haven't touched on that will round out this conversation?Patrick Hsu (44:50):I mean, I think it's very early days here at Arc.Patrick Hsu (44:53):When we founded Arc, we asked ourselves, how do we measure success? We don't have customers or revenue in the way that a typical startup does. And we felt sort of three things. The first was research institutes live and die by their talent. Can we actually hire incredible people when we make offers to people we want to come, do they come? The second was, when those folks do come to Arc, do they feel like they're able to work on important research programs that they couldn't do sort of at their prior university or company? And then longer term, the third thing was, and there's just no shortcut around this, you need to do important work. And I think we've been really excited that there are early signs that we're able to do all three of these things, and we're still, again, just following the same scaling laws that we're seeing in natural language and vision, but for the domain of biology. And so, we're excited about what's ahead and think if there are folks who are interested in learning more about Arc, just shoot me an email or DM.Eric Topol (46:07):Yeah, well I would just say, congratulations on what you've already achieved. I know you're going to keep rocking it because you already have in a short time. And for anybody who doesn't know about Arc Institute and your work and your team, I hope this is going to be putting them on notice actually what can be accomplished outside of the usual NIH funded model, which is kind of a risk-free zone where you basically have to have your results nailed down before you send in your proposal frequently, and it doesn't do great things for young people. Really, I think you actually qualify in that demographic where it's hard for them to break in for getting NIH grants and also for this type of work that you're doing. So we'll look for the next bridge beyond bridge RNAs of your just fantastic efforts. So Patrick, thanks so much for joining us today, and we'll be checking back with you and following all the great work that you'll be doing in the times ahead.Patrick Hsu (47:14):Thanks so much, Eric. It was such a pleasure to be here today. Appreciate the opportunity.*******************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informative!Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly help fund our summer internship programs.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

Join Simtheory: https://simtheory.aiCommunity: https://thisdayinai.com-----Thanks for listening and all of your support of the show!-----CHAPTERS:00:00 - Fun with ChatGPT Advanced Voice Mode & Moshi04:11 - Thoughts on Advanced Voice Mode, Voice Mode API & Voice as an Interface29:31 - We Share Simtheory.ai Model Usage Data: Forget Benchmarks... Which Models Do People Actually Use?38:35 - Llama 3.2 with Vision: Thoughts on New Models and Llama Stack55:02 - Google Gemini 1.5 Pro 002 Update: Thoughts on New Model1:04:56 - OpenAI achieves AGI and Fires All Executives1:08:06 - Mike's Weekly LOL

The future of UN peacekeeping and the “new models” it needs to create to remain relevant in the 21st Century are set to be discussed at the landmark Summit of the Future taking place in New York from 22 September.There are currently 11 UN missions around the world, mainly in Africa and the Middle East.Their goal is to help countries torn by conflict to create the conditions for lasting peace.Participants at the Summit of the Future will discuss, the global architecture for international cooperation, which includes peacekeeping.Cristina Silveiro sat down with the head of UN peacekeeping operations, Jean-Pierre Lacroix to take stock of how the UN and its partners can contribute to lasting peace.

Todays show: Alex Wilhelm joins Jason to discuss OpenAI's latest model and implications (11:49), Uber's partnership with Waymo and its implications (38:16), Analyzing Mr. Beast's content creation and business culture (1:01:21). and more! * Timestamps: (0:00) Jason and Alex kick off the show. (3:57) Highlights from the All-In Summit (9:16) Tackling media criticism and the state of journalism (10:23) Washington Post - TWiST listeners can subscribe for just 50 cents per week for your first year at https://www.washingtonpost.com/twist (11:49) Alex and Jason dive into OpenAI's latest model and implications (19:46) Examination of OpenAI's corporate structure and financing (20:39) AssemblyAI - Get 100 free hours to start building at https://www.assemblyai.com/twist (21:51) Further analysis of OpenAI's business model (27:08) OpenAI's valuation and perspectives on speculative investment (30:26) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/twist24 (32:07) The landscape of AI startup investments (35:20) How AI is enhancing developer productivity (36:33) AI's potential in consumer markets (38:16) Uber's partnership with Waymo and its implications (41:15) The realities of autonomous vehicle technology deployment (47:00) The government's role in autonomous vehicle tech and partnerships with big tech (52:26) Economic insights: Predictions on the Fed rate cut (56:26) The influence of interest rates on startups and investment strategies (58:52) Discussing cost of living adjustments and food delivery trends (1:00:44) Innovations in autonomous food preparation (1:01:21) Analyzing Mr. Beast's content creation and business culture (1:09:12) How large companies can maintain focus on goals * Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/ Check out the TWIST500: twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp * Mentioned on the show: OpenAI o1's announcement: https://openai.com/index/learning-to-reason-with-llms/ OpenAI release article on The Verve: https://www.theverge.com/2024/9/12/24242439/openai-o1-model-reasoning-strawberry-chatgpt Supermaven article: https://techcrunch.com/2024/09/16/ai-coding-assistant-supermaven-raises-cash-from-openai-and-perplexity-founders/ Twitter post from Michael Seibel: https://x.com/mwseibel/status/1835063692117103090 Waymo and Uber expand partnership: https://waymo.com/blog/2024/09/waymo-and-uber-expand-partnership/ Polymarket on Fed Interest Rates: https://polymarket.com/event/fed-interest-rates-september-2024?tid=1726496650092 Leaked Mr Beast doc: https://drive.google.com/file/d/11dV24Mda_kNEBCLtPtBomWG4IkngvQKK/view Travis Kalanick | All-In Summit 2024 video**:** https://www.youtube.com/watch?v=8j7lwauJN2s * Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm * Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Thank you to our partners: (10:23) Washington Post - TWiST listeners can subscribe for just 50 cents per week for your first year at https://www.washingtonpost.com/twist (20:39) AssemblyAI - Get 100 free hours to start building at https://www.assemblyai.com/twist (30:26) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://www.brex.com/twist24 * Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland * Check out Jason's suite of newsletters: https://substack.com/@calacanis * Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com * Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

Gary Antonacci is back on the show after having released a new research paper with Carlo Zarattini from Concretum Research which constitutes a 100-year study on trend following US sectors. The strategy deployed in the paper has an impressive long-term track record, averaging an annual return of 18.2% with 12.6% volatility and a Sharpe Ratio of 1.39. Using Keltner and Donchian channels for entries & edits, volatility-based position sizing and a universe of 48 sectors, the simple model is surprisingly robust and a testament to the enduring power of trend following. Get all the links over at www.thealgorithmicadvantage.com

Intelligence Notes: WEF/ Blockchain/ Decentralized Governance and New Models (KAIST). In this session we revisit my eschatological prognostications and futurologists ideas concerning the “THE NEW WORLD ORDER/ORDER OUT OF CHAOS”- Beast System. (Bonus Session) To support the [Show] and its [Research] with Donations and Gifts, please send all funds and gifts to :$aigner2019 (cashapp) or https://www.paypal.me/Aigner2019 or Zelle (1-617-821-3168).

In this episode, we explore MidJourney's latest advancements in imaging technology and discuss the significant shift away from Discord, providing users with a more streamlined experience. Get on the AI Box Waitlist: ⁠⁠https://AIBox.ai/⁠⁠ Conor's AI Course: https://www.ai-mindset.ai/courses Jaeden's Podcast Course: https://podcaststudio.com/courses/ Conor's AI Newsletter: https://www.ai-mindset.ai/ Jaeden's AI Hustle Community: https://www.skool.com/aihustle/about

Jon England is the Education Policy Analyst at Libertas Institute. He is a fourteen-year veteran public schools who became frustrated with the lack of innovation, transparency and accountability in the system, and decided to leave the system and join Libertas to work on empowering parents, and defending parental rights.Find Jon on X @Principal_Jon Website: https://libertas.orgTIMESTAMPS03:16 - Welcome Jon!04:47 - COVID: The Final Straw09:01 - School vs. Parents13:12 - The School Trap20:00 - The Push to College32:32 - New Models for K12 44:15 - Government Roadblocks to Alternatives48:55 - Let's Talk About School Choice...1:00:00 - How to Get More Involved in Making Education BetterSUPPORT MY WORK:// Donate:Buy Me a Coffee: https://www.buymeacoffee.com/trwlPayPal: paypal.me/deborahfillman// Join:If you want to join weekly calls with me and my audience, and get access to my curated lists of education enrichment and homeschooling resources, join one or both of my private communities: TRWL @Wokescreen: https://wokescreen.com/thereasonwelearn/TRWP Parent Support Group: https://wokescreen.com/the-reason-we-parent///Work With Me:I offer a wide range of consulting services to parents and parent advocacy organizations. Learn more about my services, and book my time using these links Tutoring & Homeschool Teaching: https://thereasonwelearn.com/online-tutoring-and-homeschool-teaching/ College Counseling and Essay Coaching: https://thereasonwelearn.com/consulting/ Education Consulting & School Search: https://thereasonwelearn.com/1942-2/ Public Speaking: https://thereasonwelearn.com/speaking/ Writing: https://thereasonwelearn.com/writing-2///Do Business With My Affiliates Purchase books from Heroes of Liberty with my referral link and get 10% off! https://heroesofliberty.com/?ref=Zqpq...Enroll your child in The Socratic Experience, a virtual school grades 3-12. They provide Socratic discussions of classic texts with a commitment to rationality while supporting students in entrepreneurial and creative projects. My listeners can now get a 10% discount by using the link below!https://socraticexperience.com/parent-guide/?utm_source=thereasonwelearn#publicschoolsystem #walkaway #publicschool #education #microschool #homeschooling #schoolchoice--- Support this podcast: https://podcasters.spotify.com/pod/show/debf/support Get full access to The Reason We Learn at thereasonwelearn.substack.com/subscribe

- Rivian Burns Through Cash to Prepare for New Models - Honda Posts Record $3.3 Billion Operating Profit - Honda Launches New EV In China - BMW Tests Humanoid Robots in South Carolina - Mercedes Goes After Counterfeit Parts Makers - Waymo Expands Service in California - Software Upgrade Cuts Hyundai and Kia Thefts in Half - Ford Launches New Explorer Police Vehicle

- Rivian Burns Through Cash to Prepare for New Models - Honda Posts Record $3.3 Billion Operating Profit - Honda Launches New EV In China - BMW Tests Humanoid Robots in South Carolina - Mercedes Goes After Counterfeit Parts Makers - Waymo Expands Service in California - Software Upgrade Cuts Hyundai and Kia Thefts in Half - Ford Launches New Explorer Police Vehicle

Full Ep released to subscribers: 1 Aug 2024 | To join New Models, find us via patreon.com/newmodels & newmodels.substack.com // A few weeks ago, artist and friend of New Models, Bjarne Melgaard reached out with an episode proposal. He'd become close with actor and artist Paz de la Huerta, whose debut solo show had just closed at Rutkowski;68 Gallery in Paris. Bjarne had been painting Paz for a new series of work and she was interested in speaking to us together with him about that collaboration, her own art, and their shared healing. With this episode, we give you an edit of the resulting conversation — one that is as much about friendship, trauma, and healing as it is about media, image-making, and power. For more: Ruttkowski;68 (Paris)
 Gallery VI, VII (Oslo)
 https://bjarnemelgaard.no & @bjarnemelgaard (IG)

Full Ep released to subscribers: 21 July 2024 | To join New Models, find us via patreon.com/newmodels & newmodels.substack.com // From AI to global power alignments to domestic political sentiments in the US and EU, 2024 is shaping up to be a frontier zone year of an era to come. Joining us on this episode is journalist James Pogue who is no stranger to the edges of the political present and uncommonly adept at anticipating where they lead. When Pogue last came on the show in 2022, his piece on America's New Right for Vanity Fair had just gone viral. More recently, he's been penning a three-part series for Granta magazine on the turbulent power games in the resource rich Sahel region, where he spent the better part of last year. We discuss both on this episode, unmooring ideations of what ‘Right' and ‘Left' now mean. For more:
@jameshensonpogue (X) https://granta.com/gold-fever-in-the-coup-belt/ https://granta.com/wagner-in-africa/ https://www.vanityfair.com/news/2022/04/inside-the-new-right-where-peter-thiel-is-placing-his-biggest-bets

Try SimTheory Beta: https://simtheory.ai/chatShow Notes: https://thisdayinai.com/bookmarks/63-ep70Join our community: https://thisdayinai.comMerch: https://www.thisdayinaimerch.com/=====Thanks for listening!=====CHAPTERS:00:00 - It's good to be back...04:12 - Chris's Learnings From Playing Poker Using AI32:11 - Initial thoughts on GPT-4o Mini from OpenAI44:15 - Mistral's NeMo55:01 - Codestral Mamba1:04:48 - MathΣtral: Scientific Discovery or BS?1:12:59 - New Models on LMSYS: Column-r Column-u, Eureka by Google1:09:22 - BOOM FACTOR for new models1:16:39 - JD Vance Doesn't Want AI Regulatory Capture1:18:41 - Final thoughts

In this episode of the Lead On Podcast, Jeff Iorg, president of the Executive Committee of the Southern Baptist Convention, discusses models of bivocational and covocational ministry, challenging traditional views and highlighting their benefits. He shares personal experiences, such as his time at the Northwest Baptist Convention, where he expanded his staff significantly by integrating bivocational and covocational workers. He describes different models, including part-time ministry combined with secular jobs, retirees in ministry roles, and self-salaried staff. He emphasizes the importance of valuing and strategically utilizing these workers, noting their potential for significant contributions with minimal financial outlay. Iorg also discusses managing life balance for these workers and ensuring their ministry roles are impactful and sustainable.

Are you ready for a whirlwind of AI innovations and industry shifts?In this week's episode of Leveraging AI,  Isar Meitis takes you on the latest and most exciting developments in the AI world. From new text-to-video models to major industry changes, this episode is packed with valuable insights and updates that you won't want to miss.In this episode, you'll discover:The latest in text-to-video technology and its potential applications.Insights into new AI models released by major companies like OpenAI, Google, and Stability AI.How AI is revolutionizing content creation and what this means for creatives and businesses.Updates on AI courses and training opportunities to enhance your skills.Don't forget to check out our AI Business Transformation Course, where you can learn to harness AI for your business. Use the promo code LEVERAGINGAI100 for a special discount, valid until the end of next week. For more details, visit this link> https://multiplai.ai/ai-course/  About Leveraging AI The Ultimate AI Course for Business People: https://multiplai.ai/ai-course/ YouTube Full Episodes: https://www.youtube.com/@Multiplai_AI/ Connect with Isar Meitis: https://www.linkedin.com/in/isarmeitis/ Free AI Consultation: https://multiplai.ai/book-a-call/ If you've enjoyed or benefited from some of the insights of this episode, leave us a five-star review on your favorite podcast platform, and let us know what you learned, found helpful, or liked most about this show!

Full ep released to subscribers: 10 Aug 2023 | To join New Models, find us via patreon.com/newmodels & newmodels.substack.com _ Artist Trevor Paglen speaks with New Models about systems of “influence” past and present – pointing to a transition from a world of surveillance capitalism that is potentially becoming one of PSYOPS capitalism. This conversation follows Paglen's parallel 2023 exhibitions “Hide the Real, Show the False” at n.b.k. Berlin and “You've Just Been F*cked by PSYPOS” at Pace Gallery in New York. For more: Tw/X: @trevorpaglen https://paglen.studio/ Jak Ritger, https://www.punctr.art/unlimited-hangout-the-ufo-story