Podcasts about masterjohn

Was man teilweise über Vitamin D hört, klingt fast zu schön, um wahr zu sein. Andererseits deuten hunderte verschiedener Forschungsarbeiten darauf hin, dass Vitamin D zur Vorbeugung einer Reihe von Krankheiten beitragen kann – darunter Osteoporose, Depression, Autoimmun- und Herz-Kreislauf-Erkrankungen. Ärzte empfehlen es. Gesundheits- und Fitnesspodcaster sprechen darüber. Vielleicht geht Dir sogar Deine Lieblingstante damit auf die Nerven. Bei all dem Hype ist die Frage berechtigt: "Solltest Du Vitamin D einnehmen?" Hier sind die Antworten – und die neuesten Fakten über ein faszinierendes Vitamin, das ein wahrer Verwandlungskünstler ist. ____________ *WERBUNG: KoRoDrogerie.de: 5% Ermäßigung auf alles mit dem Code „FMM“ beim Checkout. ____________ Ressourcen zur Folge: Literatur: Ratgeber Nahrungsergänzung – Mark Maslow (kostenlos auf MarathonFitness) Blut: Die Geheimnisse unseres flüssigen Organs* – Ulrich Strunz (Heyne) Vitamin D* – Uwe Gröber, Michael F. Holick (Wissenschaftl. Verlagsgesellschaft) Blutuntersuchung (Selbsttest): Vitamin D Test* von Medivere Präparate: D-Form 2.000 K2+* von FormMed D-Form 2.000 K2+ vegan* von FormMed ____________

What if I told you that a single biochemical process could be the key to unlocking your body's full potential? In this eye-opening episode of The Dr. Josh Axe Show, we dive deep into the world of methylation - a crucial process affecting over 40% of Americans. Dr. Axe breaks down this complex topic, revealing how it impacts everything from your mood to your ability to detoxify. Tune in to discover: The 'sticky note' analogy that makes understanding methylation a breeze Why poor methylation could be behind your unexplained fatigue, brain fog, or mood swings The shocking connection between methylation and your risk of heart disease and autoimmune disorders Nature's top methylation boosters - including one surprising food that outperforms all others How your gut health might be the secret key to optimizing your methylation pathway The MTHFR gene variant: what it means and why you should care Simple, actionable steps to support your body's methylation process starting today Whether you're a health enthusiast or struggling with unexplained symptoms, this episode is a must-listen. Dr. Axe delivers complex information in an easy-to-understand format, equipping you with the knowledge to take control of your health. By the end of this show, you'll have a clear understanding of methylation and a practical toolkit to optimize this vital process in your body. Don't miss out on this game-changing information - your cells will thank you! Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook Tik-Tok ------  Links:  Ferira, L. (2021). "The Role of Methylation in Human Health." Journal of Nutrition. Rountree, R. (2020). "Environmental Impacts on Methylation." Environmental Health Perspectives. Masterjohn, C. (2022). "Riboflavin and Its Importance for Methylation." Nutritional Biochemistry. CDC (2023). "Antibiotic Resistance and Usage Statistics." WHO (2022). "COVID-19 and Antibiotic Usage." Smith, A. D., & Refsum, H. (2016). "Homocysteine, B Vitamins, and Cognitive Impairment." Annual Review of Nutrition. Watanabe, F., & Yabuta, Y. (2013). "Vitamin B12 Sources and Bioavailability." Food and Nutrition Bulletin. Bailey, L. B., & Gregory, J. F. (2011). "Folate and Other Methyl Donors: Effects on the Risk of Cardiovascular Disease." Current Opinion in Lipidology. Pinna, K. L. (2018). "Probiotics and Gut Health: Mechanisms and Applications." Frontiers in Microbiology. Ulta Labs. (2023). "MTHFR Gene Variation Testing and Homocysteine Testing."

In this interview, Chris Masterjohn, who has a Ph.D. in nutritional sciences from the University of Connecticut, and I discuss nutritional individuality, and how to assess your own personal nutritional needs.

Question: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex? Short Answer: Vitamin C is nearly ubiquitously distributed in plant tissues, and is never bound to any enzyme as a structural complex. Vitamin C promotes absorption of iron from plant foods, inhibits copper absorption, and de-loads copper from ceruloplasmin, which may play a role in distributing copper to tissues. Vitamin C is not capable of destroying ceruloplasmin. These functions follow directly from vitamin C as an electron donor and there is no evidence whatsoever that whole food vitamin C behaves differently in these respects than synthetic vitamin C. However, daily needs in most contexts are 2-400 milligrams of vitamin C per day, which is below the dose shown to potentially cause problems with copper. Getting this from whole foods or whole food supplements is better than using synthetic vitamin C because it avoids GMO corn and Chinese synthetics and provides a host of other beneficial constituents alongside the vitamin C. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-hair-trace-mineral-analysis In that batch of free episodes you will also find the answer to this question: Is Hair Mineral Testing Useful?  What's the Deal With Seed Oils? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Butyrate for Hashimoto's? What else? What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios? Is the solution to a respiratory chain disorder to take Niagen? If I have high manganese on an HTMA, do I need to detox? Should CFS patients target reducing their serum BH4? What to do about low alkaline phosphatase? If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals? Difficulty getting Quest to do the lactate/pyruvate ratio correctly. Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+? How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter? Is monounsaturated fat the best fat? Manganese followup. Do you need to stop taking biotin before a biotin test? What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low? NAD infusions, yay or nay? Why do I feel better after a warm shower, even better than after sunshine? Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick? Do home blood drop tests have to be pricked at the finger? Is it true that my boyfriend was just born a night owl? How much eating out is too much? When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-a55  

Question: What Is the Real Issue With Seed Oils? Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not acutely cause oxidative stress, but their polyunsaturated fatty acids (PUFAs) are more vulnerable than any other macronutrient to oxidative damage. Oxidative stress can increase because of nutrient deficiencies, toxins, infections, other sources of inflammation, alcohol, or smoking, and it will inevitably increase as a function of aging. As oxidative stress increases, more PUFAs in the tissues mean more damage. At least 0.6 milligrams of vitamin E should be gotten per gram of PUFA in the diet, but vitamin E cannot fully protect against PUFA, so their intake should be moderated to the very low levels needed, as obtained by eating fatty fish once or twice a week, eating eggs daily, and eating 4-8 ounces of liver per week. Additional secondary problems with them include residual solvents and heat damage prior to intake, but the main issue is that we do not want to increase our tissue PUFA content more than needed. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-hair-trace-mineral-analysis In that batch of free episodes you will also find the answer to this question: Is Hair Mineral Testing Useful? Is Whole Food Vitamin C Really Different? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Butyrate for Hashimoto's? What else? What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios? Is the solution to a respiratory chain disorder to take Niagen? If I have high manganese on an HTMA, do I need to detox? Should CFS patients target reducing their serum BH4? What to do about low alkaline phosphatase? If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals? Difficulty getting Quest to do the lactate/pyruvate ratio correctly. Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+? How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter? Is monounsaturated fat the best fat? Manganese followup. Do you need to stop taking biotin before a biotin test? What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low? NAD infusions, yay or nay? Why do I feel better after a warm shower, even better than after sunshine? Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick? Do home blood drop tests have to be pricked at the finger? Is it true that my boyfriend was just born a night owl? How much eating out is too much? When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-a55  

Question: How useful is hair trace mineral analysis (HTMA) for nutritional testing? Short Answer: Hair trace mineral analysis is included as an optional add-on in the comprehensive nutritional screening from Testing Nutritional Status: The Ultimate Cheat Sheet, because it can capture data for some ultra-trace minerals for which there are no better-validated tests, and it might capture a pattern that might not be picked up as quickly with blood work, such as a mineral transport issue. However, its utility is limited by the fact that hair mineral content is not well validated as a test for any specific mineral, is generally anti-validated when there is enough science on a mineral (such as zinc, where hair zinc does not go down in deficiency), and should not be used as a central piece of data without corroboration from other more well-validated tests, which exist for most of the nutrients. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-hair-trace-mineral-analysis In that batch of free episodes you will also find the answer to this question: What's the Deal With Seed Oils? Is Whole Food Vitamin C Really Different? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the June 16, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Butyrate for Hashimoto's? What else? What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios? Is the solution to a respiratory chain disorder to take Niagen? If I have high manganese on an HTMA, do I need to detox? Should CFS patients target reducing their serum BH4? What to do about low alkaline phosphatase? If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals? Difficulty getting Quest to do the lactate/pyruvate ratio correctly. Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+? How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter? Is monounsaturated fat the best fat? Manganese followup. Do you need to stop taking biotin before a biotin test? What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low? NAD infusions, yay or nay? Why do I feel better after a warm shower, even better than after sunshine? Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick? Do home blood drop tests have to be pricked at the finger? Is it true that my boyfriend was just born a night owl? How much eating out is too much? When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-a55

Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism.  This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Can NAC hurt your gut health? Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may  Access the show notes, transcript, and comments here.  

Question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This vulnerability could result from deficiencies of any of the B vitamins, any of the electrolytes, or of iron, copper, or sulfur; from diabetes, low adrenals, or hypothyroidism; or from any of the hundreds of genetic defects in energy metabolism, only one of which is glucose 6-phosphate dehydrogenase deficiency; or any one of a huge number of toxins that impair energy metabolism. Chronically, vitamin C may increase the harms of iron overload or contribute to copper deficiency. The main ways to manage these latter issues are to take vitamin C away from meals, to maintain good copper status through proper dietary intake, and to treat iron overload with phlebotomy. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Can NAC hurt your gut health? How to Find the Root Cause of Autoimmunity? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may  

Question: Can NAC hurt your gut health? Short Answer: N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days to disrupt biofilms and make it easier for antimicrobials to kill bacteria. Animal studies suggest that acute doses up to 6 grams do not deplete mucus or cause ulceration, but that an acute dose of 17.5 grams can deplete mucus and cause ulcers within two hours. Human studies suggest that 10 grams per day can be used for 24 weeks with fewer than 1 in 6 people complaining of gastrointestinal side effects. Yet, chronic use of NAC will thin the mucus, disrupt the biofilms used by normal healthy microbiota, and possibly deliver excessive sulfur to certain components of the microbiome. Therefore, I would not use it except for specific, targeted reasons, and I would not use it at a dose higher than needed or for a duration longer than needed. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-nac-biofilms-vitamin In that batch of free episodes you will also find the answer to this question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? How to Find the Root Cause of Autoimmunity? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: GLA to lower hydroxyhaemopyrrolin-2-one? When would I use the StrateGene and Genova Methylation Panel for nutritional testing? Energy metabolism as a root cause of gut issues? Nutrition for skin healing? Nutrition for hypnic jerks? Suggestions for snoring or sleep apnea? Nutrition to protect against restaurant meals? What is the cause of crusty eyes in the morning? What causes brain fog? How much oxalate should one eat each day? Should I be concerned about low alkaline phosphatase? What nutrients give tall children to short parents? Energy metabolism impairment mimicking Wilson's disease. Can taking digestive enzymes reduce our own production? Rapid-fire response to non-winners from the question contest. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-may Access the show notes, transcript, and comments here.  

Question: How can I protect against oxalates? Short Answer: Getting 300-400 mg calcium between food and supplements at each meal will minimize oxalate absorption. Maintaining postprandial urine pH in the 6.4-6.8 range by getting 3-5 grams of potassium per day from food or from organic acid salts such as potassium citrate will prevent its crystallization in the kidney. Reducing dietary oxalate will prevent any possible damage in the gut. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-blood-glucose-and-oxalate In that batch of free episodes you will also find the answer to this question:  Why Should Postprandial Glucose Be Kept Under 140 mg/dL? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the April 12, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: What Causes Hypercholesterolemia and Does It Matter? How to Reverse Coronary Calcification? How to do a comprehensive nutritional screening How long after eating improperly cooked egg whites should I wait to take biotin? Is the extrusion process as harmful as some claim? How long can one fast before micronutrient deficiencies become an issue? Do B vitamins compete with each other for absorption? Why is thirst a symptom of diabetes? Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible? During a fast, does the body break down muscle? How do you rest and refeed your brain? Why would someone have high RBC magnesium but low serum magnesium? GLA deficiency? Should we eat for our ethnicity? How convincing are polyphenol studies? Can coronary calcium be driven by oxalate? Citrulline for vasodilation How to reduce catabolism Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia's thyroid numbers Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-april Access the show notes, transcript, and comments here.    

Question: Why should postprandial blood glucose be kept under 140 milligrams per deciliter? Short Answer: When blood glucose rises above 140 mg/dL, this is the approximate point at which it spills into the polyol pathway at a greater-than-normal rate, which represents a suboptimal state of metabolism that is likely to hurt antioxidant status and compromise detoxification pathways as well as the recycling of vitamin K and folate. It must be kept in mind that a healthy person will adapt to glycemic loads they consume regularly. Thus, a one-time spike above 140 mg/dL should never be used to conclude anything whatsoever. Only repeated spikes above this level with repeated consumption of the same glycemic load over several days to several weeks should be used as a cause for concern. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-blood-glucose-and-oxalate In that batch of free episodes you will also find the answer to this question: How can I protect against oxalates? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the April 12, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: What Causes Hypercholesterolemia and Does It Matter? How to Reverse Coronary Calcification? How to do a comprehensive nutritional screening How long after eating improperly cooked egg whites should I wait to take biotin? Is the extrusion process as harmful as some claim? How long can one fast before micronutrient deficiencies become an issue? Do B vitamins compete with each other for absorption? Why is thirst a symptom of diabetes? Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible? During a fast, does the body break down muscle? How do you rest and refeed your brain? Why would someone have high RBC magnesium but low serum magnesium? GLA deficiency? Should we eat for our ethnicity? How convincing are polyphenol studies? Can coronary calcium be driven by oxalate? Citrulline for vasodilation How to reduce catabolism Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia's thyroid numbers Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-april Access the show notes, transcript, and comments here.  

Question: What is the relationship between copper and estrogen? Short Answer: Estrogen moves copper from the mother's bloodstream to the fetus during pregnancy. Its action at the intestines is poorly understood but I believe estrogen and progesterone interact to promote intestinal copper absorption. Maintaining pregnancy-level hormones while not pregnant poses a risk of promoting too much absorption of copper from food without transferring it to a growing baby. Copper status should be monitored when using supplemental hormones to avoid copper toxicity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-hair-graying-copper  In that batch of free episodes you will also find the answer to this question: How to slow or reverse graying of hair? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the March 14, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How to slow or reverse graying of hair? What about that new erythritol study? Can nicotinamide riboside cause hemolytic anemia in someone with G6PDH deficiency? Why is citric acid alkalinizing? If I switch my vitamin E to tocotrienols, am I missing anything? Vitamin A deficiency and toxicity symptoms at the same time? Vitamin A in pregnancy How long should I wait to measure whole blood riboflavin after making a change to my supplement? How to stack supplements for blood pressure? Rejuvant calcium alpha-ketoglutarate for anti-aging? Are dietary AGEs a problem? Is it safe to keep taking high-dose zinc? What's the best way to get phosphorus? Weight loss question. How to eat to 80% full Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-march  Access the show notes, transcript, and comments here.

Question: How to slow graying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of energy abundance (body fat, insulin sensitivity, thyroid hormone, adequate protein, individualized meeting of carbohydrate needs, good management of psychosocial stress, supporting neuroendocrine signaling with copper, vitamin C, zinc, and glycine, and supporting thyroid function with iodine and selenium); the biochemical infrastructure of energy production (all the B vitamins, iron, copper, sulfur, magnesium, potassium, and managing genetic idiosyncrasies impacting energy metabolism), and antioxidant protection (protein, vitamin C, vitamin E, zinc, copper, selenium, iron, and manganese). This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-hair-graying-copper  In that batch of free episodes you will also find the answer to this question: What is the relationship between copper and estrogen? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the March 14, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: What is the relationship between copper and estrogen? What about that new erythritol study? Can nicotinamide riboside cause hemolytic anemia in someone with G6PDH deficiency? Why is citric acid alkalinizing? If I switch my vitamin E to tocotrienols, am I missing anything? Vitamin A deficiency and toxicity symptoms at the same time? Vitamin A in pregnancy How long should I wait to measure whole blood riboflavin after making a change to my supplement? How to stack supplements for blood pressure? Rejuvant calcium alpha-ketoglutarate for anti-aging? Are dietary AGEs a problem? Is it safe to keep taking high-dose zinc? What's the best way to get phosphorus? Weight loss question. How to eat to 80% full Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-march  Access the show notes, transcript, and comments here.

Question: How much iron can we absorb at once? Short Answer: High-dose iron will produce more total absorbed iron, but will also leave more in the gut, which could cause constipation or disturb the gut microbiome. If desperate for quick relief, 200 milligrams per day of iron taken in the morning will work faster than lower doses or the same dose taken in the afternoon. For most people, however, I believe it is best to start with 18 milligrams of iron, and only increase it to 27 or 36 milligrams, or higher, if needed. If it is difficult to raise iron with a supplement, try eating a temporary carnivore diet that includes egg yolks but not whites, or at least try taking your iron with a breakfast that matches this description. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis  In that batch of free episodes you will also find the answers to these questions: Is It Important to Get Vitamin D Sulfate Specifically From the Sun? What cofactors are needed to synthesize and recycle BH4? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Is It Important to Get Vitamin D Sulfate Specifically From the Sun? What cofactors are needed to synthesize and recycle BH4? What nutrients are important for long-term PPI use? For how long does transferrin saturation respond to recent iron-rich food? Muscle spasms: creatine, creatinine, sodium, and potassium. Hematologists ignore iron saturation. How to detox arsenic? Could folic acid supplements impair BH4 recycling? How to increase butyrate? More on hematologists and transferrin saturation. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february  Access the show notes, transcript, and comments here.

Question: What cofactors are needed to synthesize and recycle BH4? Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR). This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis In that batch of free episodes you will also find the answers to these questions: Is It Important to Get Vitamin D Sulfate Specifically From the Sun? How Much Iron Can We Absorb At Once? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Is It Important to Get Vitamin D Sulfate Specifically From the Sun? How Much Iron Can We Absorb At Once? What nutrients are important for long-term PPI use? For how long does transferrin saturation respond to recent iron-rich food? Muscle spasms: creatine, creatinine, sodium, and potassium. Hematologists ignore iron saturation. How to detox arsenic? Could folic acid supplements impair BH4 recycling? How to increase butyrate? More on hematologists and transferrin saturation. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february  Access the show notes, transcript, and comments here.

Question: Is it important to get vitamin D sulfate specifically from the sun? Short Answer: It is important to get morning outdoor sunlight as close to every day as possible for your circadian rhythm, and to get some exposure to unprotected sunlight during the day when UV is available, but at doses less than needed to cause reddening, and it is equally important to always avoid burning. There are many reasons for this, and the cholesterol sulfate hypothesis — to which the vitamin D sulfate hypothesis is peripheral — is an interesting and worthy hypothesis but should not be the final arbiter of your sun exposure habits. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis In that batch of free episodes you will also find the answers to these questions: What cofactors are needed to synthesize and recycle BH4? How Much Iron Can We Absorb At Once? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: What cofactors are needed to synthesize and recycle BH4? How Much Iron Can We Absorb At Once? What nutrients are important for long-term PPI use? For how long does transferrin saturation respond to recent iron-rich food? Muscle spasms: creatine, creatinine, sodium, and potassium. Hematologists ignore iron saturation. How to detox arsenic? Could folic acid supplements impair BH4 recycling? How to increase butyrate? More on hematologists and transferrin saturation. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february

Question: If a person has a hereditary weakness for Branched Chain Amino Acid Catabolism would this impact the type of diet they might choose to loose weight? Should they limit protein if it will increase their need for nutrients like Biotin?What are all the possible cofactors we should consider supplementing to support Leucine catabolism? Short Answer: Metabolizing branched-chain amino acids requires all B vitamins except folate, calcium, magnesium, potassium, and chloride. If you have a genetic impairment in this pathway, then reducing branched-chain amino acid intake and doubling down on cofactors is important during weight loss because the pathway will be stressed more in the catabolic state. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-plant-compounds-and  In that batch of free episodes you will also find the answers to these questions: Can plant foods and their phytochemicals be used to reduce arterial plaque? How do I consume omega-3 without hurting my omega-6 status? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the January 21, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Can plant foods and their phytochemicals be used to reduce arterial plaque? How do I consume omega-3 without hurting my omega-6 status? Could carnitine help a fatty acid oxidation disorder? Should anti-inflammatories be taken away from workouts? How does vitamin C affect autoimmune disease? Folate form and purines Can methylene blue help the respiratory chain? Best references for omega-3 and inflammation resolution? Smoothies and blood sugar Is transdermal magnesium oil effective for osteoarthritis? Why do K2 and Mg help my nerve pain? Should I separate my potassium benzoate and vitamin C supplements? The best and most simple comprehensive micronutrient panel. How much K2 is needed in pregnancy? How do I accentuate the fasting-feeding cycle? Could K2 help with environmental pollution? Why do shoulders crack when we get older? Why do I react poorly to anti-inflammatory foods? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-january 

Question: If I don't want to hurt my omega 6 status through my omega 3 intake, how do I do that? Is it simply a question of taking them at separate times? Or is it a question of dose? And if it is a question of dose, how do I know when to start eating fish and taking my omega 3 supplement again? Short Answer: How they are combined in meals is not important, but it is important not to have too much EPA in cell membranes relative to arachidonic acid, and this is driven by cumulative intake over years. For someone who has consumed too much EPA for many years, the best approach is to eat liver and egg yolks for arachidonic acid while getting omega-3s from a DHA supplement and not from fish, fish oil, or fish liver oil. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-plant-compounds-and In that batch of free episodes you will also find the answers to these questions: Can plant foods and their phytochemicals be used to reduce arterial plaque? If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the January 21, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Can plant foods and their phytochemicals be used to reduce arterial plaque? If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? Could carnitine help a fatty acid oxidation disorder? Should anti-inflammatories be taken away from workouts? How does vitamin C affect autoimmune disease? Folate form and purines Can methylene blue help the respiratory chain? Best references for omega-3 and inflammation resolution? Smoothies and blood sugar Is transdermal magnesium oil effective for osteoarthritis? Why do K2 and Mg help my nerve pain? Should I separate my potassium benzoate and vitamin C supplements? The best and most simple comprehensive micronutrient panel. How much K2 is needed in pregnancy? How do I accentuate the fasting-feeding cycle? Could K2 help with environmental pollution? Why do shoulders crack when we get older? Why do I react poorly to anti-inflammatory foods? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-january  Access the show notes, transcript, and comments here.

Question: Can plant foods and their phytochemicals be used to reduce arterial plaque? Short Answer: Yes, but if you don't have specific intolerances to plant compounds the best thing to do is simply aim to meet your vitamin and mineral targets from a diet rich in fruits, vegetables, herbs, and spices, rather than trying to use specific plant compounds from specific studies in any specific amount. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-plant-compounds-and In that batch of free episodes you will also find the answers to these questions: How do I consume omega-3 without hurting my omega-6 status? If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the January 21, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Can plant foods and their phytochemicals be used to reduce arterial plaque? How do I consume omega-3 without hurting my omega-6 status? If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? Could carnitine help a fatty acid oxidation disorder? Should anti-inflammatories be taken away from workouts? How does vitamin C affect autoimmune disease? Folate form and purines Can methylene blue help the respiratory chain? Best references for omega-3 and inflammation resolution? Smoothies and blood sugar Is transdermal magnesium oil effective for osteoarthritis? Why do K2 and Mg help my nerve pain? Should I separate my potassium benzoate and vitamin C supplements? The best and most simple comprehensive micronutrient panel. How much K2 is needed in pregnancy? How do I accentuate the fasting-feeding cycle? Could K2 help with environmental pollution? Why do shoulders crack when we get older? Why do I react poorly to anti-inflammatory foods? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-january  

Question: What can be done about twitching? Short Answer: Most twitching will be driven by glutamate/GABA balance or acetylcholine regulation, and the most likely nutritional issues are any of the electrolytes or any factor that influences energy metabolism. The best way to address it is to consider the conditions that influence it and then trial and error your way through each potential nutritional issue in order of which ones make the most sense for your individual case first. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-phosphatidylcholine In that batch of free episodes you will also find the answers to these questions: Phosphatidylcholine and TMAO Vitamin K2 and Undercarboxylated Osteocalcin If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Inositol, What Is It Good For? If I am at risk of heart disease, and phosphatidylcholine raises my TMAO, should I stop the supplement? If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation? Maragen Calcium Could slow methylation cause high selenium levels? My current thoughts on cholesterol and heart disease If I already have oxidative stress, what ducks should I have in a row before supplementing with iron? Is it safe to take eight milligrams of zinc daily without copper? What to do about developing sensitivities to an increasingly broad range of foods? What else to do about hemochromatosis besides phlebotomy? If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS? What to do about chronically elevated amylase and lipase? What to do about a non-drinker having very high GGT and occasionally high ALT? What are the most common vitamin and mineral deficiencies? What are the best supplements, vitamins, and minerals for OCD and depression? What is the connection between low pyruvate and high ketones? Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?  Do I trust food allergy tests? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-december Access the show notes, transcript, and comments here.

Question: If undercarboxylated osteocalcin has health benefits, and vitamin K2 decreases it, what does that mean for K2 supplementation? Short Answer: Vitamin K2 helps secure osteocalcin in bone matrix, where it is decarboxylated and released as an endocrine hormone in response to certain stimuli. When released, it acts to optimize insulin secretion, insulin sensitivity, fuel use during exercise, and male testosterone. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-phosphatidylcholine In that batch of free episodes you will also find the answers to these questions: Phosphatidylcholine and TMAO What to Do About Twitching If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Inositol, What Is It Good For? If I am at risk of heart disease, and phosphatidylcholine raises my TMAO, should I stop the supplement? Maragen Calcium Could slow methylation cause high selenium levels? My current thoughts on cholesterol and heart disease If I already have oxidative stress, what ducks should I have in a row before supplementing with iron? Is it safe to take eight milligrams of zinc daily without copper? What to do about developing sensitivities to an increasingly broad range of foods? What else to do about hemochromatosis besides phlebotomy? If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS? What to do about chronically elevated amylase and lipase? What to do about a non-drinker having very high GGT and occasionally high ALT? What are the most common vitamin and mineral deficiencies? What are the best supplements, vitamins, and minerals for OCD and depression? What is the connection between low pyruvate and high ketones? Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?  An algorithm to fix twitching Do I trust food allergy tests? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-december Access the show notes, transcript, and comments here.

Question: If I'm at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement? Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. There are thousands of things that should be given equal weight as potential contributors to heart disease, but TMAO gets the most attention because the Cleveland Clinic has an incredible PR machine to spread their research, which serves to bolster their financial interest in marketing the test. That said, it is not a universal necessity to supplement with phosphatidylcholine. If you are concerned about your TMAO, you can try substituting trimethylglycine (TMG), and ultimately judge the value of each supplement by whether it is helping you in a demonstrable way. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-phosphatidylcholine In that batch of free episodes you will also find the answers to these questions: Vitamin K2 and Undercarboxylated Osteocalcin What to Do About Twitching If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Inositol, What Is It Good For? If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation? Maragen Calcium Could slow methylation cause high selenium levels? My current thoughts on cholesterol and heart disease If I already have oxidative stress, what ducks should I have in a row before supplementing with iron? Is it safe to take eight milligrams of zinc daily without copper? What to do about developing sensitivities to an increasingly broad range of foods? What else to do about hemochromatosis besides phlebotomy? If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS? What to do about chronically elevated amylase and lipase? What to do about a non-drinker having very high GGT and occasionally high ALT? What are the most common vitamin and mineral deficiencies? What are the best supplements, vitamins, and minerals for OCD and depression? What is the connection between low pyruvate and high ketones? Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?  An algorithm to fix twitching Do I trust food allergy tests? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-december Access the show notes, transcript, and comments here.

Question: How do I fix low blood sugar on vegan keto? Short Answer: Consider how important it is for your ketones to be elevated. Most likely you need to eat more protein, which will lower your ketones. I would aim for a minimum of 0.8 grams per kilogram of ideal bodyweight and consider using 1.2 grams per kilogram of ideal bodyweight. If this does not work, consider all of the nutrients involved in energy metabolism — all of the B vitamins, iron, copper, sulfur, magnesium, potassium — but especially biotin and B6 for their disproportionate role in gluconeogenesis. If the protein you need to normalize your blood sugar does reduce your ketones to a level that are not giving you the benefits you are looking for, you could consider raising them with exogenous ketones. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Brain Fog on Calcium, Vitamin D, or K2 Raising Ceruloplasmin When Copper Won't Do It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Brain Fog on Calcium, Vitamin D, or K2 How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? How do I get my ceruloplasmin up if copper doesn't raise it? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here.

Question: Why would vitamin D, vitamin K2, and calcium give me brain fog? Short Answer: Most likely by decreasing serum phosphorus. The solution is to balance these nutrients with vitamin A and phosphorus. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-questions-on-supplements In that batch of free episodes you will also find the answers to these questions: Low Blood Sugar on Vegan Keto Raising Ceruloplasmin When Copper Won't Do It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the November 19, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Low Blood Sugar on Vegan Keto How Do I Increase My ATP? Nutrition for Recovery from Alcoholism How to decrease MCV after chemo? What happened to vitamin B4? Should I eat foods specifically for their antioxidant status? How do I get my ceruloplasmin up if copper doesn't raise it? Why would bovine serum immunoglobulins help gut health? Nicotinamide Riboside and Cancer If I need lecithin for gut health, should I worry about its omega-6? What do I think of patented Sucrosomial magnesium and zinc? Is my problem magnesium transport or magnesium excretion? What to do about severe osteoarthritis and muscle stiffness? Should I worry if 5 mg P5P raises my plasma B6 above normal? Is nascent iodine safe when weaning off of thyroid hormone? How to avoid false zeros in Cronometer? What does it mean if I have more energy when taking CoQ10? If NADPH oxidase is unregulated to fight pathogens, is taking antioxidants good or bad? What if my needs for vitamin A and zinc are higher than the tolerable upper intake levels? How accurate are vitamin E tests? Quick redux on muscle stiffness How do I handle my first emergence from lockdown if I am worried about being relatively immunosuppressed? If I supplement with iodine, do I need to supplement with selenium? Should I worry about the beta-carotene in my multivitamin? Why do I wake up tense and with a headache to my alarm clock? Why does starch make me wake up in the middle of the night with increased respiration? What causes crusty eyes? Which nutrients need to be spread out across the day? What are nutritional causes of hypnic jerks? To replicate Weston Price's reversal of tooth decay, do I need dairy? Why would I have a bad reaction to milk thistle? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-november Access the show notes, transcript, and comments here.

Short Answer: Plasma zinc is the single most important marker of zinc status. Urine zinc may decline faster in deficiency. Hair zinc increases with supplementation but does not decrease in deficiency. Plasma zinc is decreased by inflammation, oxidative stress, the ovulatory and luteal phases of the menstrual cycle, probably pregnancy and oral contraceptive use, and any kind of stress that leads to an adrenal output. If plasma zinc declines despite supplementation, corroborate that this reflects zinc status by showing normal hair zinc and low urine zinc. Use symptoms as the ultimate arbiter of whether zinc supplementation is helping. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Glutathione Intolerance: Getting to the Bottom of It If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october  Access the show notes, transcript, and comments here.

Short Answer: It could be byproducts of any of the three amino acids that make up the glutathione molecule, which include the individual amino acids, ammonia, hydrogen sulfide, sulfite, and propionyl CoA, or it could be microbial metabolites of glutathione produced in the gut. The full answer contains seven hypothesis-driven tests that can be done at home to determine the cause. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Statins Vs. Sulfur for Heart Disease Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here.

Short Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of interest and industry funding. There are plausible mechanisms by which they may hurt mitochondrial function and promote soft tissue calcification. Dietary sulfur appears to lower cholesterol. While Lester Morrison showed 1500 milligrams per day of chondroitin sulfate could reduce cardiac events 7-fold, this has a theoretical potential to hurt the microbiome. My preferred way of getting sulfur is 1.2-1.8 grams per kilogram bodyweight of total non-collagen protein, with an emphasis on animal protein. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-statins-versus-sulfur In that batch of free episodes you will also find the answers to these questions: Glutathione Intolerance: Getting to the Bottom of It Why Plasma Zinc is the Best Marker of Zinc Status If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the October 12, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: NADH vs NMN vs NR An unexplained rise in urine ketones Spreading out calcium across meals What should we have in our cold season cabinet? What besides diet could cause my high morning glucose on a CGM? Will some older people benefit from supplementing carnitine? What do I think about the CGM fad? Could my low triglycerides be cholestasis? Why limit the dose of cod liver oil? Why do I always feel better when my sulfur problems are worse? Should I use one lab's reference range with another lab's results? Is it safe to eat roasted potatoes? How much weight should I give genetic SNPs in my nutrition? High RBC magnesium but low serum: what could it mean? Burning in the stomach: what could it be? Should I treat low plasma amino acids by supplementing them? Why would MK-4 cause heart palpitations? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-october Access the show notes, transcript, and comments here.

Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-cognitive-health-mct In that batch of free episodes you will also find the answers to these questions: Does whey protein hurt the kidneys or otherwise hurt our health Why would someone not tolerate methyl donors even if they need them? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Why isn't my ferritin as high as diabetics when my transferrin saturation is higher? Why are vitamins A and E needed alongside D and K? Sunflower lecithin versus phosphatidylcholine supplements How do I reduce congestion while consuming dairy? Could eggs be raising triglycerides by curing fatty liver? Why would homocysteine ever be high when you can just use it to make glutathione? Why did my eye start twitching after sweating more than usual this weekend? Why do I now think A and D should be in roughly 1:1 ratios? Would MK-7 be enough to take with D or do I need MK-4? Why does water make me hungry? What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2? Is it safe to take zinc carnosine long term? Why did I recommend only using high-dose zinc for COVID protection for one year? Why did I recommend limiting quercetin phytosome to three months? Why take MK-4 when it has such a short half-life? How to make bowel movements more regular? Could freeze dried animal beef supplements cause gut infections? Do I recommend food sensitivity testing? What are the nutritional causes of restless leg syndrome? What do I think of drinking deuterium-depleted water for COVID severity? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-september Access the show notes, transcript, and comments here.

Short Answer: The main problem with too much protein, particularly animal protein, is that acidity may hurt the bones and increase the risk of calcium oxalate kidney stones, but this can be obviated by balancing it with organic acids, which have bicarbonate-sparing effects that are alkalinizing. The best index of the organic acid content of foods is the potassium content. This balance can be achieved with 750 to 1500 milligrams of potassium for every 100 grams of protein. This is not specific to whey protein. Other than allergies, none of the claimed harms of whey protein are convincing. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-cognitive-health-mct In that batch of free episodes you will also find the answers to these questions: Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline? Why would someone not tolerate methyl donors even if they need them? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Why isn't my ferritin as high as diabetics when my transferrin saturation is higher? Why are vitamins A and E needed alongside D and K? Sunflower lecithin versus phosphatidylcholine supplements How do I reduce congestion while consuming dairy? Could eggs be raising triglycerides by curing fatty liver? Why would homocysteine ever be high when you can just use it to make glutathione? Why did my eye start twitching after sweating more than usual this weekend? Why do I now think A and D should be in roughly 1:1 ratios? Would MK-7 be enough to take with D or do I need MK-4? Why does water make me hungry? What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2? Is it safe to take zinc carnosine long term? Why did I recommend only using high-dose zinc for COVID protection for one year? Why did I recommend limiting quercetin phytosome to three months? Why take MK-4 when it has such a short half-life? How to make bowel movements more regular? Could freeze dried animal beef supplements cause gut infections? Do I recommend food sensitivity testing? What are the nutritional causes of restless leg syndrome? What do I think of drinking deuterium-depleted water for COVID severity? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-september Access the show notes, transcript, and comments here.

Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in people who do not experience cognitive decline. Cognitive decline does appear to be driven by decreases in brain energy metabolism, but these are not best described as a specific impairment in glucose handling. MCT oil can be modestly beneficial and a ketogenic diet can probably be somewhat more beneficial in people who have cognitive decline from any type. There is no evidence to support using it as a preventative. For prevention, I believe we should focus on aerobic fitness, nutrients required for healthy energy metabolism and antioxidant defense, and maintaining metabolic health with a healthy body composition and a healthy physical activity routine that includes the proper spread of a portfolio of different types of exercise. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-cognitive-health-mct In that batch of free episodes you will also find the answers to these questions: Does whey protein hurt the kidneys or otherwise hurt our health Why would someone not tolerate methyl donors even if they need them? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the September 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Why isn't my ferritin as high as diabetics when my transferrin saturation is higher? Why are vitamins A and E needed alongside D and K? Sunflower lecithin versus phosphatidylcholine supplements How do I reduce congestion while consuming dairy? Could eggs be raising triglycerides by curing fatty liver? Why would homocysteine ever be high when you can just use it to make glutathione? Why did my eye start twitching after sweating more than usual this weekend? Why do I now think A and D should be in roughly 1:1 ratios? Would MK-7 be enough to take with D or do I need MK-4? Why does water make me hungry? What's the proper ratio of calcium to magnesium, vitamin D, and vitamin K2? Is it safe to take zinc carnosine long term? Why did I recommend only using high-dose zinc for COVID protection for one year? Why did I recommend limiting quercetin phytosome to three months? Why take MK-4 when it has such a short half-life? How to make bowel movements more regular? Could freeze dried animal beef supplements cause gut infections? Do I recommend food sensitivity testing? What are the nutritional causes of restless leg syndrome? What do I think of drinking deuterium-depleted water for COVID severity? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-september Access the show notes, transcript, and comments here.  

Short Answer: If it can't be explained by the dose of salt, it may be that the salt is not being absorbed orally. Glucose, starch, or simply a meal consumed alongside the salted water may help with this. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: Protein and Longevity How to Increase or Decrease SHBG? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here.

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: Protein and Longevity  Why is an IV more hydrating than salted water? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august Access the show notes, transcript, and comments here.

Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of protein or calories might otherwise provide, and a high protein intake supports bone mass, muscle mass, and the detoxification of carcinogens, all of which are important to longevity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2 In that batch of free episodes you will also find the answers to these questions: How to Increase or Decrease SHBG?  Why is an IV more hydrating than salted water? If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: Does which food you eat matter when everything is digested anyway? How to know if your nitric oxide is dilating your blood vessels properly? How big of a problem are transient glucose spikes above 140 mg/dL? Can I take too much collagen? What is the maximum dose of cod liver oil safe to use long-term? How much A is safe to take when I need so much to resolve my symptoms? Generalizing from cell studies of green tea catechins to cups of green tea per day. What to do about lumbar discs bulging? Why would vitamin K2 cause a nosebleed? How to balance A with D when I react poorly to D and need so much A? Why would COVID decrease HRV long-term? How to raise secretory IgA? Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research. Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august

Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here.  

Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite of an apple. It requires the preponderance of signaling. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver   In that batch of free episodes you will also find the answers to these questions:   • What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? • Reversing Fatty Liver: How Long Does It Take? • What if my A1C says I'm diabetic but my CGM says I'm fine? • Will reishi, turmeric, or curcumin tank my testosterone? • The 3 Phases of Fasting: And How to Get Kicked Out of Each One   If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up:   https://chrismasterjohnphd.substack.com/qanda   Learn more about the Masterpass here:   https://chrismasterjohnphd.substack.com/about   This snippet is from the July 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:   • How do I know if my digestive enzymes are helping or hurting? • Why does high-dose glycine give me these terrible symptoms? • How to know if my magnesium is messing with my calcium? • Why do I have vitamin A symptoms when my lab tests are normal? • What is my favorite web site for finding enzymatic cofactors? • Potassium citrate vs potassium chloride • Major problems with B vitamin supplements • Is food sensitivity testing useful? • What nutrients might help with dihydropyrimidine dehydrogenase deficiency? • Does lipoic acid hurt methylation? • Sulfur SIBO that just won't go away. • Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. • Helping bile flow without pharmaceuticals. • Managing pernicious anemia. • Do we really need to meet the RDA for calcium? • Could stretch marks be a sign of copper toxicity? • When iron saturation is driven by low binding capacity. • How do I know if I need methyl-free Bs? • What causes heat intolerance?   Here's a link to the full AMA:   https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3

Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don't at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing.   This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: hthttps://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june Access the show notes, transcript, and comments here.

Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june Access the show notes, transcript, and comments here.

SHR # 2911:: Inside the Beautiful Mind of Dr. Chris Masterjohn - The American Heart Association released a position paper on coconut oil and this is the rebuttal via Dr. Chris Masterjohn. PLUS How did the low-carb diet make the LA Lakers lose? and Dr. Masterjohn's thoughts on various dietary templates. original interview; July 2017.

My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made from organic corn from small New England farms. The corn is nixtimalized, which frees the niacin, makes it more digestible, and eliminates 97-100% of the mycotoxins (based on studies with aflatoxin). Then they are fried in grass-fed beef tallow! They are full-bodied and feel nourishing, and they are the perfect saltiness. That is, I do not feel like a company has tagged me as eating a low-salt diet just because I want a healthy chip. The bulk of your diet should be unprocessed and minimally processed foods, but there is an important place for health snacks! Get your MASA chips today at https://chrismasterjohnphd.com/masa and use the code MASTERJOHN for 10% off. I will get a small commission at no extra cost to you. You will rarely ever find me promoting a chip, but this is one I endorse!

Short answer: You should be able to see changes on imaging within a few weeks if your approach is working well, but ultimately this is entirely dependent on how negative your “delta fatty liver = (fat in) - ((fat out) + (fat burned))” equation is. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here.

Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of “biological vitamin D activity” from them. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:   https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? Reversing Fatty Liver: How Long Does It Take? What if my A1C says I'm diabetic but my CGM says I'm fine? Will reishi, turmeric, or curcumin tank my testosterone? The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included: How do I know if my digestive enzymes are helping or hurting? Why does high-dose glycine give me these terrible symptoms? How to know if my magnesium is messing with my calcium? Why do I have vitamin A symptoms when my lab tests are normal What is my favorite web site for finding enzymatic cofactors Potassium citrate vs potassium chloride Major problems with B vitamin supplements Is food sensitivity testing useful? What nutrients might help with dihydropyrimidine dehydrogenase deficiency? Does lipoic acid hurt methylation? Sulfur SIBO that just won't go away. Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. Helping bile flow without pharmaceuticals. Managing pernicious anemia. Do we really need to meet the RDA for calcium? Could stretch marks be a sign of copper toxicity? When iron saturation is driven by low binding capacity. How do I know if I need methyl-free Bs? What causes heat intolerance? Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here.

In this episode, I am speaking with Dr. Chris Masterjohn – who has a Ph.D. in nutritional sciences and who is widely regarded as one of the top nutritional biochemistry experts in the world – about the big holes in the data on COVID and vaccines.

Short Answer: Measure this against whether it increases your likelihood of burning. If it does, it's probably a bad thing, but if it doesn't, or if it lowers your risk of burning, that's a good thing. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Short Answer: Vaccination shouldn't change the vitamin D requirement. Quarterly testing makes sense for someone who has never tested before or who wants to make sure they stay in range during COVID, but generally testing yearly around the mid-point of seasonality for you, once you know your variation, is plenty. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Short Answer: BH4 is expensive and requires very high doses, so if the problem is modest it can much more easily be solved by taking tyrosine. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Short Answer: While the body will tend to use TMG for methylation in the fasting state, it is normally found in food, so you should be able to absorb it with meals and hold on to it for later use, much as we do with folate. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Certainly, the fat-soluble vitamins, vitamins A and D, both important. Lauric acid as a fat. Coconut oil might be a good fat choice for the fat in your diet. Monolaurin would be a very good choice for a supplement. Lauricidin is the best monolaurin to take, 3 to 10 grams a day. Be careful of your bowel tolerance, spread it out among your meals, and cut back if it starts to loosen your stool. Elderberry, which has mostly been studied in the context of flu, that probably has good antiviral properties. Garlic. Garlic appears to require very high doses if you're just taking a garlic extract. If you're taking stabilized allicin, 180 micrograms a day is good. But you could raise the question what if you're missing on some of the other important compounds in the garlic. I'll debate with some of my friends about that, but what's really been tested is 180 micrograms of stabilized allicin. Then zinc for sure in the immune response is super important. Then you get back to nutrient density. Although I'd give special importance to vitamins A and D, arachidonic acid just mentioned, zinc and copper, both, and then those supplements. If you're missing any one particular nutrient, then you're going to wind up with a specific vulnerability that will persist until you fix that one nutrient. Thanks, anonymous. This Q&A can also be found as part of a much longer episode, here: https://themasterpass.chrismasterjohnphd.com/products/mastering-nutrition/categories/2811841/posts/9361575

"What do you think is the best clinical way to monitor COMT function if you have already tested for SNPs?"   One way you can look at it is through the DUTCH test — which is at dutchtest.com — it's a dried urine hormone testing platform, they have a methylation index that is based on the methylation of estrogen. For example; the main significance of COMT, is related to long-term risk of estrogen-related cancers.     Acute symptoms are primarily going to manifest in the brain in the relation between COMT and dopamine.    The higher your COMT activity, the more flexible your brain.    The lower your COMT activity, the more rigid your brain.    If your nutrition is straight and you don't have a psychological disorder, that's just a personality trait.   They call this the worrier/warrior, phenotype.    High COMT activity; you don't worry as much, like a warrior who picks his battles, wins, and repeats. There is nothing to worry about, the only concern is victory.   If you are a low COMT activity; you're not a warrior, you're a worrier. You think about all the possible ways something could go wrong. Instead of moving forward with an image of invincibility, you struggle to move at all, like a deer in the headlights.    But that's the extremes. Within most of the population, it's just a personality trait.    So, you really look at, how is your mind operating? If your mind is getting stuck on stuff, low COMT. If your mind is racing around to different things, high COMT. If that's just your personality, don't worry about it. But if it's starting to interfere with your life, then that's where it matters.    Low COMT, focus on methyl donors: B12, folate, choline, betaine, some of the other assisting B vitamins.    High COMT, focus on  methyl buffers: Glycine.    This Q&A can also be found as part of a much longer episode, here: https://chrismasterjohnphd.com/podcast/2019/02/09/ask-anything-nutrition-feb-1-2019/ 

So, deep sleep is, primarily what's going on in deep sleep is that all of your biogenic amines, which are most of the neurotransmitters that you make from protein with the possible except — like depending on how you classify it, you could say ultimately you make melatonin from protein, but it's not a biogenic amine. Biogenic amines, which are the catecholamines — all are basically shut off. They're probably not zero, zero, but they're almost zero during sleep. Acetylcholine is also shut down during deep sleep, but it pops up during REM sleep. I really don't think this is a supplement issue.  First of all, you definitely don't want to be taking anything that has acetylcholinesterase inhibitors at night.  Non-organic foods have pesticides that are acetylcholinesterase inhibitors. I don't know if that's relevant here dose-wise. Things that improve cognitive function are often acetylcholinesterase inhibitors. So, gingko biloba is one. I wouldn't take that at night. There are drugs that treat neurological problems, especially Alzheimer's, that are acetylcholinesterase inhibitors; I wouldn't take those at night.  I'm on the fence about whether you should take choline at night. I think it's most likely fine to eat eggs at night. If you're taking something like alpha-GPC; I'm not sure. You might want to avoid that at night if you find, particularly if you find that when you're tracking your sleep with an Oura ring your REM is higher than normal and your deep sleep is lower than normal.  But other than that — I would say that methylation support is very important to help lower some of the important biogenic amines. Histamine, for example, is primarily gotten rid of with methylation in the brain and if your histamine levels are high during the day, it might cause anxiety during the night and that could interfere with your deep sleep. Electrolytes are also super important. Calcium, magnesium, salt and potassium. All these things you need to get straight in order for your sleep cycle to be working right. If your cortisol is high at night or other factors of anxiety are high at night you might want a targeted supplement there, like phosphatidylserine — the evidence is conflicting, but has been used to lower the stress response.  I don't think it's a blanket answer to that question. I think it's like figuring out what's the cause of the low deep sleep and working from there.

Despite a shifting scientific landscape, dietary cholesterol is still a hotly debated topic. Joe Rogan and Chris Kresser eat eggs every day, while the plant-based community still loves to highlight the supposed dangers of dietary cholesterol. High cholesterol has historically been associated with poor health, but is there a range where cholesterol levels get too low? Our guest in this episode of the podcast believes the combination of a genetic predisposition combined with a strict vegan diet caused him to develop a dangerous cholesterol deficiency. A former assistant professor of Nutrition Science at Brooklyn College, Chris Masterjohn, Ph.D. is one of the smartest minds in nutrition. Chris shares a fascinating story of how going vegan caused him to develop nutrient deficiencies which led to a battle with mental illness and anxiety. Chris' subsequent focus on nutrient-dense, animal-based foods restored his health and changed his perspective on how the foods we eat play a large role in cognitive function. We cover a wide range of topics with Chris and he takes a number of controversial positions in this episode, including who shouldn't eat eggs, nutrient deficiencies that are most likely to arise on a carnivore diet, whether “fancy” blood testing metrics like LDL-P are necessary to gauge cardiovascular health, why some people fail on vegan diets and much more.