Podcasts about eclinicalmedicine

Episode 189: Intermittent Fasting (Religious and Sports)Future Doctors Carlisle and Kim give recommendations about patients who are fasting for religious reasons, such as Ramadan. They also explain the benefits and risks of fasting for athletes and also debunked some myths about fasting. Dr. Arreaza add input about the side effects of fasting and ways to address them.    Written by Cameron Carlisle, MSIV (RUSM) and Kyung Kim, MSIV (AUC). Editing by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction: In the last episode on fasting (#179), we explored how intermittent fasting (IF) can help manage type 2 diabetes by improving insulin sensitivity, promoting weight loss, and lowering inflammation. We discussed the benefits of methods like 16:8 time-restricted eating and the 5:2 meal plan, and even compared IF to medications like metformin. Today, we're bringing that science into real life. We'll talk about how people fast for religious reasons, like during Ramadan, how athletes use IF to stay in shape, and how we can use IF as a tool in family medicine to support community health and A1c control.Intermittent Fasting in Religious PracticeRamadan just ended on 3/30/25, but this is a great time to talk about the broader role of fasting in religion and health. Many faiths incorporate fasting into spiritual practice and understanding this can help us better support our patients.Islam (Ramadan): Ramadan is a month where Muslims fast from dawn to sunset, focusing on spiritual reflection and self-control. No food or drink is consumed during daylight hours. Despite this, studies have shown that with good planning, fasting during Ramadan does not significantly impair physical performance or metabolic health.Key health tips for patients observing Ramadan:Hydrate well between iftar (sunset) and suhoor (pre-dawn).Break the fast with dates and water to gently replenish energy and electrolytes.Eat balanced meals with complex carbs, protein, and healthy fatsAvoid greasy, heavy foods right after fastingLight exercise (such as a walk) after iftar is beneficialReview medications with a healthcare provider, especially for those on insulin or sulfonylureas.For example: Metformin should be taken when you break your fast and then again before dawn. If its an extended-release metformin, take it at night. Metformin does not cause significant hypoglycemia and can be continued during Ramadan. Basal insulin is advised to be given at Iftar, and the dose should be reduced by 25-35% if the patient is not well managed. And regarding the fast-acting insulin, it requires a little more reading, so you can look it up and learn about it. Judaism: In Judaism, fasting is practiced on days like Yom Kippur and Tisha B'Av, typically lasting 25 hours without food or water. These fasts are spiritual and reflective, and patients with medical conditions may seek guidance on how to participate safely.Christianity: Many Christians fast during Lent, either by abstaining from certain foods or limiting meal frequency. Some practice partial-day fasts or water-only fasts for spiritual renewal.A branch of Christianity known as The Church of Jesus Christ of Latter-day Saintsoften observe a 24-hour fast on the first Sunday of each month, known as Fast Sunday, where they abstain from food and drink and donate the cost of meals to charity. This practice is both spiritual and communal.Cameron: Fasting for religious reasons, when done safely, can align with IF protocols and be culturally sensitive for diverse patients in family medicine.IF in Athletes and PerformanceIntermittent fasting is gaining popularity in the sports world. Athletes are using IF to improve body composition, increase fat oxidation, and enhance metabolic flexibility. A recent study, known as the DRIFT trial and published in Annals of Internal Medicine, found that fasting three non-consecutive days a week led to more weight loss than daily calorie restriction. Participants lost an average of 6.37 pounds more over 12 months.Why? Better adherence. People found the 3-day fasting schedule easier to stick to than counting calories every day.Benefits of IF for athletes:Encourages fat burning (via AMPK activation and GLUT4 upregulation, listen to ep. 179).Helps maintain lean muscle while reducing fat.No major drop in performance when meals and workouts are timed properly.What are some practical tips?Schedule workouts during or just before eating windows.Eat protein-rich meals post-workout.Avoid intense training during long fasts unless adapted.Stay hydrated, especially in hot environments or endurance sports.Broader Applications and Myths Around IFHormonal Effects of IF: In addition to improving insulin sensitivity, IF also affects hormones such as ghrelin (which stimulates hunger, remember it as growling) and leptin (which signals fullness). Over time, IF may help the body regulate appetite better and reduce cravings. IF can also decrease morning cortisol levels, the stress hormone. That's why it's important to monitor sleep, hydration, and stress levels when recommending IF.Circadian Rhythm Alignment: Emerging research shows that aligning eating times with natural light/dark cycles—eating during the day and fasting at night—can improve metabolic outcomes. This practice, known as early time-restricted eating (eTRE), has been shown to lower blood glucose, reduce insulin levels, and improve energy use. Patients who eat earlier in the day tend to have better results than those who eat late at night.Myths and Clarifications on IF:-“Fasting slows metabolism” In fact, short-term fasting may boost metabolism slightly due to increased norepinephrine. -“You can't exercise while fasting.” Many people can safely train during fasted states, especially for moderate cardio or strength training. -“Skipping breakfast is bad.” For some, skipping breakfast is a useful IF strategy—as long as total nutrition is maintained. You can break your fast at 2:00 pm, it does have to be at 7:00 AM.What to Eat When Breaking a FastBreaking a fast properly is just as important as fasting itself. Whether it's after a Ramadan fast or a 16-hour fast, the goal is to replenish energy gently and restore nutrients.Ideal foods to break a fast:Dates and water: provide quick energy, potassium, and fiberSoups: lentil or broth-based soups are gentle on digestionComplex carbs: whole grains like brown rice or oatsLean proteins: chicken, fish, eggs, legumesFruits and vegetables: hydrate and provide fiberHealthy fats: nuts, avocado, olive oilProbiotics: yogurt or kefir for gut supportBalanced meals with carbs, protein, and healthy fats help the body transition smoothly back to a fed state.Using IF in Family Medicine and Community HealthIntermittent fasting can be a practical, cost-effective strategy in family medicine. In areas with high rates of obesity and diabetes, like Kern County, IF offers a lifestyle-based tool to improve metabolic health, especially in underserved populations. IF is free!How IF can help in family medicine:Lower A1c levels: improves insulin sensitivity and glucose controlPromote weight loss: decreases insulin resistance and inflammationReduce medication dependence: fewer meds needed over time for some patientsEncourage patient engagement: flexible and easier to follow than strict calorie countingFit diverse lifestyles: aligns with religious and cultural practicesAddress food insecurity: structured eating windows can help patients stretch limited food resourcesHow to apply IF in clinic:Start the conversation by asking if the patient has heard of IFRecommend simple starting points: 12:12 or 14:10Emphasize hydration and nutrient-dense mealsMonitor labs and symptoms, especially in diabetic patientsAdjust medications to avoid hypoglycemiaProvide follow-up and patient education handouts if possibleWhat if a patient isn't ready to try fasting?For those not ready to commit to intermittent fasting, one effective alternative is walking after meals. A simple 10–20 minute walk post-meal can help stimulate GLUT4 receptors in skeletal muscle, promoting glucose uptake independent of insulin. This reduces the demand on pancreatic beta cells and may help improve blood sugar control over time. This strategy is particularly useful for patients with insulin resistance or early-stage type 2 diabetes.Conclusion: Intermittent fasting is not one-size-fits-all, but it can be a powerful tool for both individual and community health. From Ramadan to race day, IF has a place in family medicine when used thoughtfully. Encourage patients to work with their healthcare providers to find an approach that fits their lifestyle, medical needs, and personal values. IF is a cost-effective toolEven without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:American Academy of Family Physicians. (2022). "Intermittent Fasting: A Promising Treatment for Diabetes." AAFP Community Blog. https://www.aafp.org/pubs/afp/afp-community-blog/entry/intermittent-fasting-a-promising-treatment-for-diabetes.htmlHealthline. (2023). "What Breaks a Fast? Foods, Drinks, and Supplements." https://www.healthline.com/nutrition/what-breaks-a-fast.Sarri KO, Tzanakis NE, Linardakis MK, Mamalakis GD, Kafatos AG. Effects of Greek Orthodox Christian Church fasting on serum lipids and obesity. BMC Public Health. 2003 May 16;3:16. doi: 10.1186/1471-2458-3-16. PMID: 12753698; PMCID: PMC156653. https://pmc.ncbi.nlm.nih.gov/articles/PMC156653/.Shang, Y., et al. (2024). "Effects of Intermittent Fasting on Obesity-Related Health Outcomes: An Umbrella Review." eClinicalMedicine.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00098-1.Abaïdia AE, Daab W, Bouzid MA. Effects of Ramadan Fasting on Physical Performance: A Systematic Review with Meta-analysis. Sports Med. 2020 May;50(5):1009-1026. doi: 10.1007/s40279-020-01257-0. PMID: 31960369. https://pubmed.ncbi.nlm.nih.gov/31960369/.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

Die Abwesenheit von Unglück und Katastrophen bedeutet nicht automatisch Glück und Zufriedenheit. Das kommt langsam auch in der Psychotherapie an, die sich in der Vergangenheit vor allem mit Krankheitsbildern beschäftigt und daher eher das Ziel hat, das Unglück und die Katastrophen zu beseitigen. Aber wäre es nicht schön, wenn wir wieder glücklich sein könnten? Leon und Atze beschäftigen sich dieses Mal mit Therapieansätzen, die positive Gefühle im Fokus haben und was wir für unseren Alltag daraus mitnehmen können. Fühlt euch gut betreut Leon & Atze Start ins heutige Thema: 12:07 min. VVK Münster 2025: https://betreutes-fuehlen.ticket.io/ Instagram: https://www.instagram.com/leonwindscheid/ https://www.instagram.com/atzeschroeder_offiziell/ Der Instagram Account für Betreutes Fühlen: https://www.instagram.com/betreutesfuehlen/ Mehr zu unseren Werbepartnern findet ihr hier: https://linktr.ee/betreutesfuehlen Tickets: Atze: https://www.atzeschroeder.de/#termine Leon: https://leonwindscheid.de/tour/ Quellen: https://www.scientificamerican.com/article/new-psychotherapies-that-focus-on-positive-experiences-could-better-treat/ Studie zu PAT: Craske, M. G., Meuret, A. E., Echiverri-Cohen, A., Rosenfield, D., & Ritz, T. (2023). Positive affect treatment targets reward sensitivity: A randomized controlled trial. Journal of Consulting and Clinical Psychology. https://pmc.ncbi.nlm.nih.gov/articles/PMC10213148/ Studie zu ADepT: Dunn, B. D., Widnall, E., Warbrick, L., Warner, F., Reed, N., Price, A., ... & Kuyken, W. (2023). Preliminary clinical and cost effectiveness of augmented depression therapy versus cognitive behavioural therapy for the treatment of anhedonic depression (ADepT): a single-centre, open-label, parallel-group, pilot, randomised, controlled trial. EClinicalMedicine,. https://www.thelancet.com/pdfs/journals/eclinm/PIIS2589-5370(23)00261-4.pdf Studie zu SkillJoy: LaFreniere, L. S., & Newman, M. G. (2023). Reducing contrast avoidance in GAD by savoring positive emotions: Outcome and mediation in a randomized controlled trial. Journal of Anxiety Disorders. https://pmc.ncbi.nlm.nih.gov/articles/PMC9976801/ Redaktion: Andy Hartard Produktion: Murmel Productions

The eClinicalMedicine team come together to discuss 2024 and 2025 in an editorial round table. Ben Burwood is joined by Hannah Linne and Rachel Kerslake to discuss obesity, AI, recessive dystrophic epidermolysis bullosa, HIV engagement among adolescents, and the intersection between health and politics.Read the articles mentioned in this podcast:Safety and tolerability of losartan to treat recessive dystrophic epidermolysis bullosa in children (REFLECT): an open-label, single-arm, phase 1/2 trial https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00479-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmFrom diagnosis to deadlifts: navigating exercise with type 1 diabetes https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00266-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmHIV interventions across the care continuum for adolescents in high-burden countries: a systematic review and meta-analysis https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00568-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmHealthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trialhttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00054-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmClinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspectivehttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00115-9/fulltextFluid accumulation in critically ill children: a systematic review and meta-analysishttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00293-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmA core outcome set for maternal and neonatal health research and surveillance of emerging and ongoing epidemic threats (MNH-EPI-COS): a modified Delphi-based international consensushttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00604-7/fulltextConference News piecesUK Congress on Obesity 2024 https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00471-1/fulltext?dgcid=bContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

ResourcesAlemu BK, Wang CC, Li L, Zhu Z, Li Q, Wang Y. Effect of preconception antibiotics exposure on female reproductive health and pregnancy outcomes: a systematic review and meta-analysis. EClinicalMedicine. 2024;78:102935. Published 2024 Nov 22. doi:10.1016/j.eclinm.2024.102935Shao S, Pan W, Wang B, et al. Association between antibiotic exposure and the risk of infertility in women of childbearing age: A case-control study. Ecotoxicol Environ Saf. 2023;249:114414. doi:10.1016/j.ecoenv.2022.114414Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA,Thacker SB. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 2000;283:2008-12.

Send us a textIn this episode of 'Ask the Chiropractor,' Dr. Brant Hulsebus from Rockford, Illinois, discusses a recent research paper on strategies for treating lower back pain, emphasizing the effectiveness of chiropractic care over invasive medical treatments. The research paper, published in eClinicalMedicine, argues for movement-based care rather than pharmaceuticals or aggressive imaging. Dr. Hulsebus stresses the importance of chiropractor-medical doctor collaboration, sharing his experience in interdisciplinary settings, and explores why such partnerships are rare, often due to systemic politics and financial interests within healthcare systems. He encourages viewers to seek chiropractic opinions for back pain treatments.www.rockforddc.com

Send us a textIn this episode of 'Ask the Chiropractor,' Dr. Brant Hulsebus from Rockford, Illinois, discusses a recent research paper on strategies for treating lower back pain, emphasizing the effectiveness of chiropractic care over invasive medical treatments. The research paper, published in eClinicalMedicine, argues for movement-based care rather than pharmaceuticals or aggressive imaging. Dr. Hulsebus stresses the importance of chiropractor-medical doctor collaboration, sharing his experience in interdisciplinary settings, and explores why such partnerships are rare, often due to systemic politics and financial interests within healthcare systems. He encourages viewers to seek chiropractic opinions for back pain treatments.www.rockforddc.com

In this episode, Brett, Phil and Martin reflect on the year. We chat about favourite podcasts, papers and conferences in our usual informal manner (well probably even more informal than normal). Papers we mention are listed below. Cimen C, Bathoorn E, Loeve AJ, Fliss M, Berends MS, Nagengast WB, et al. Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope. Antimicrob Resist Infect Control 2024;13(1):31. https://doi.org/10.1186/s13756-024-01386-5 Torres-Teran MM, Greentree DH, Varghese MM, Cadnum JL, Pavis RL, Saade EA, et al. Identifying and Remediating Super-splasher Sinks to Reduce Dispersal of Pathogens From Sink Drains. Open Forum Infect Dis 2024;11(7):ofae293. https://doi.org/10.1093/ofid/ofae293 Bush M, Bennett CM, Hutchinson A, Bouchoucha SL. Post implementation quarantine recommendations that support preparedness: A systematic review and quarantine implementation capability framework. Infect Dis Health 2024;29(3):152-71. https://doi.org/10.1016/j.idh.2024.02.004 Dhar S, Jinadatha C, Kilgore PE, Henig O, Divine GW, Todter EN, et al. Lowering the Acquisition of Multidrug-Resistant Organisms (MDROs) With Pulsed-xenon (LAMP) Study: A Cluster-Randomized, Controlled, Double-Blinded, Interventional Crossover Trial. Clin Infect Dis 2024;79(4):1024-30. https://doi.org/10.1093/cid/ciae240 Widmer AF, Atkinson A, Kuster SP, Wolfensberger A, Klimke S, Sommerstein R, et al. Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis: A Randomized Clinical Trial. JAMA 2024;332(7):541-9. https://doi.org/10.1001/jama.2024.8531 Leistner R, Kohlmorgen B, Brodzinski A, Schwab F, Lemke E, Zakonsky G, et al. Environmental cleaning to prevent hospital-acquired infections on non-intensive care units: a pragmatic, single-centre, cluster randomized controlled, crossover trial comparing soap-based, disinfection and probiotic cleaning. EClinicalMedicine 2023;59:101958. https://doi.org/10.1016/j.eclinm.2023.101958 Denkel LA, Voss A, Caselli E, Dancer SJ, Leistner R, Gastmeier P, et al. Can probiotics trigger a paradigm shift for cleaning healthcare environments? A narrative review. Antimicrob Resist Infect Control 2024;13(1):119. https://doi.org/10.1186/s13756-024-01474-6  

In this episode, Brett, Phil and Martin reflect on the year. We chat about favourite podcasts, papers and conferences in our usual informal manner (well probably even more informal than normal). Papers we mention are listed below. Cimen C, Bathoorn E, Loeve AJ, Fliss M, Berends MS, Nagengast WB, et al. Uncovering the spread of drug-resistant bacteria through next-generation sequencing based surveillance: transmission of extended-spectrum beta-lactamase-producing Enterobacterales by a contaminated duodenoscope. Antimicrob Resist Infect Control 2024;13(1):31. https://doi.org/10.1186/s13756-024-01386-5 Torres-Teran MM, Greentree DH, Varghese MM, Cadnum JL, Pavis RL, Saade EA, et al. Identifying and Remediating Super-splasher Sinks to Reduce Dispersal of Pathogens From Sink Drains. Open Forum Infect Dis 2024;11(7):ofae293. https://doi.org/10.1093/ofid/ofae293 Bush M, Bennett CM, Hutchinson A, Bouchoucha SL. Post implementation quarantine recommendations that support preparedness: A systematic review and quarantine implementation capability framework. Infect Dis Health 2024;29(3):152-71. https://doi.org/10.1016/j.idh.2024.02.004 Dhar S, Jinadatha C, Kilgore PE, Henig O, Divine GW, Todter EN, et al. Lowering the Acquisition of Multidrug-Resistant Organisms (MDROs) With Pulsed-xenon (LAMP) Study: A Cluster-Randomized, Controlled, Double-Blinded, Interventional Crossover Trial. Clin Infect Dis 2024;79(4):1024-30. https://doi.org/10.1093/cid/ciae240 Widmer AF, Atkinson A, Kuster SP, Wolfensberger A, Klimke S, Sommerstein R, et al. Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis: A Randomized Clinical Trial. JAMA 2024;332(7):541-9. https://doi.org/10.1001/jama.2024.8531 Leistner R, Kohlmorgen B, Brodzinski A, Schwab F, Lemke E, Zakonsky G, et al. Environmental cleaning to prevent hospital-acquired infections on non-intensive care units: a pragmatic, single-centre, cluster randomized controlled, crossover trial comparing soap-based, disinfection and probiotic cleaning. EClinicalMedicine 2023;59:101958. https://doi.org/10.1016/j.eclinm.2023.101958 Denkel LA, Voss A, Caselli E, Dancer SJ, Leistner R, Gastmeier P, et al. Can probiotics trigger a paradigm shift for cleaning healthcare environments? A narrative review. Antimicrob Resist Infect Control 2024;13(1):119. https://doi.org/10.1186/s13756-024-01474-6  

In this episode we speak with paramedic and fellow student midwife, Ruth, about her experience of choosing her care provider and place of birth in her first and second pregnancies, receiving care from private midwives with admitting rights in a private hospital in Brisbane, and then after being unable to find that same model in Melbourne, choosing to birth at home with the support of private midwives (and an unofficial backup plan with a supportive OB). Ruth talks us through her marathon first labour, and how morphine (while deviating from her plan) allowed her to get the rest she needed before birthing her first daughter in the pool. Ruth speaks so eloquently about her experience, including of postpartum haemorrhage and the experience of having a big and otherwise well baby in the special care nursery. For her second birth, after being unable to find a similar model of care, Ruth chose to birth at home with private midwives. She takes us through that decision and the considerations given her history of PPH, and the fast but intense labour and waterbirth of her second daughter. We talk about the experience of continuity, the experience of good postpartum care both in hospital and then at home, and the importance of thinking about what you want out of birth and choosing your care providers and place of birth with that in mind.Links:Study comparing outcomes among women who begin labour intending to birth at home vs those intending to give birth in hospital: Reitsma, A., Simioni, J., Brunton, G., Kaufman, K., & Hutton, E. K. (2020). Maternal outcomes and birth interventions among women who begin labour intending to give birth at home compared to women of low obstetrical risk who intend to give birth in hospital: A systematic review and meta-analyses. EClinicalMedicine, 21, 100319. https://doi.org/10.1016/j.eclinm.2020.100319Kindred Midwifery, Obstetrics & Gynaecology (Ruth's Brisbane care providers)MAMA Midwives (Ruth's Melbourne care providers)

Dr Anita Lim joins Elena Bellafante, Deputy Editor for eClinicalMedicine, to talk about her recent publication of the YouScreen study, a pragmatic implementation feasibility trial that assessed the impact of offering self-sampling to non-attenders within the English cervical cancer screening programme.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00251-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

In de podcastserie proefschriften spreekt aios interne geneeskunde dr. Tessa Steenbruggen met promovendi. In deze aflevering spreekt zij met Olivier van Not over zijn proefschrift, getiteld “Overcoming challenges in advanced melanoma treatment”. Aan bod komen verschillende analyses waarbij hij gebruik maakt van data uit de Dutch Melanoma Treatment Registry (DMTR). Onder ander over het bereiken van een plateau in de overleving bij real-world patiënten die behandeld worden met immuuncheckpoint-inhibitors. Olivier zal op 3 september zijn proefschrift verdedigen aan de Universiteit van Utrecht bij prof. dr. Karijn Suijkerbuijk. Referenties Kalanithi P. (20216). When breath becomes air. Random House. Van Not OJ, et al. EClinicalMedicine 2024:69:102485. Van Not OJ, et al. JAMA Oncol 2022;8:1794-801.

Riccardo De Giorgi joins Elena Bellafante, Deputy Editor for eClinicalMedicine, to discuss the evidence that semaglutide may be associated with a reduced risk of a number of neurological and psychiatric outcomes, including cognitive deficits and dementia, as well as nicotine misuse.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00305-5/fulltext?dgcid=buzzsprout_tlv_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Rund ein Viertel aller Deutschen ist tätowiert. Doch was wird da eigentlich täglich unter die Haut gebracht? Dieser Frage gehe ich in dieser neuen Folge von “Darf's ein bisschen Chemie sein?” auf den Grund. Du erfährst, welche chemischen und physikalischen Eigenschaften Tattoofarbe hat, welche Risiken sie birgt und wie der Körper auf ein Tattoo reagiert. Quellen Links: letzter Abruf 18. und 19.07.2024 https://www.bfr.bund.de/de/fragen_und_antworten_zu_taetowiermitteln-187854.html https://gdch.app/article/tattoopigmente-in-der-haut-4136879 https://faszinationchemie.de/artikel/news/tattoos-chemiecocktails-unter-der-haut/#:~:text=Chemisch%20gesehen%20kommen%20als%20Tattoofarben,Farben%20auf%20dem%20R%C3%BCckzug%20sind https://www.umweltbundesamt.de/sites/default/files/medien/2218/publikationen/umid_1_2016_bfr_tattoo.pdf https://www.atago.net/de/databook/databook-viscosity_newtonian-fluid.php#:~:text=Eine%20Fl%C3%BCssigkeit%2C%20deren%20Viskosit%C3%A4t%20sich,nicht%2Dnewtonsche%20Fl%C3%BCssigkeit%E2%80%9C%20bezeichnet https://www.quarks.de/gesundheit/das-passiert-mit-tattoo-farbe-im-koerper/ https://www.pharmazeutische-zeitung.de/tattoos-als-moegliches-krebsrisiko-148553/ https://de.wikipedia.org/wiki/Lymphom https://www.aerzteblatt.de/blog/100829/Warum-ein-Tattoo-im-MRT-zwickt-oder-brennt‌ ChatGPT Anfragen: Hautmakrophagen Tätowierung Literaturquellen: Strandt, Helen, et al. "Macrophages and fibroblasts differentially contribute to tattoo stability." Dermatology 237.2 (2021): 296-302. Nielsen, Christel, Mats Jerkeman, and Anna Saxne Jöud. "Tattoos as a risk factor for malignant lymphoma: a population-based case–control study." EClinicalMedicine 72 (2024). Gerber, Peter Arne. "Epidemiologie von Tätowierung und Tattoo-Entfernung in Deutschland und international." Tattoos und Tattooentfernung: -alles, was man wissen muss. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. 15-18. Informationen zum Podcast Recherche und Skript: Anne Mayer Ton und Schnitt: ⁠Anne Mayer Instagram ⁠@darfs_ein_bisschen_chemie_sein⁠ Facebook ⁠@darfseinbisschenchemiesein⁠ Für weitere Zusatzmaterialen, Bonus-Folgen und die Unterstützung meiner Arbeit, kannst Du auch gerne mal bei meinem ⁠Patreon-Account⁠ vorbeischauen. Impressum und Anmerkungen unter ⁠www.greenmaya.de⁠ - Mails an green_maya@web.de Weitere Projekte von Anne Mayer: Vegane Sporternährungsberatung – Instagram: @‌veganesporternaehrung.de Kann man mal hören – der Podcast über Podcasts

Two common questions we receive are: "Does my weight affect health?" and "Is fat bad?". In today's episode, Abbey brings in the research to answer these questions. And, as always, brings in a wee bit of humor and poor singing. JOIN the Fork Diet Culture Community! - Get access to the rest of this 40 minute video, more individualized support from Abbey, connect with like-minded people, and more! Mention: Episode 04: BMI Is Bizarre and Icky. Work with us 1-on-1 More about Abbey and the team References: Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309(1):71-82. doi:10.1001/jama.2012.113905 Flegal, K., The obesity wars and the education of a researcher: A personal account, Progress in Cardiovascular Diseases, Volume 67, 2021,Pages 75-79, ISSN 0033-0620, https://doi.org/10.1016/j.pcad.2021.06.009. (https://www.sciencedirect.com/science/article/pii/S0033062021000670) Flegal KM, Ioannidis JPA, Doehner W. Flawed methods and inappropriate conclusions for health policy on overweight and obesity: the Global BMI Mortality Collaboration meta-analysis. J Cachexia Sarcopenia Muscle. 2019;10(1):9-13. doi:10.1002/jcsm.12378 Tobias DK, Hu FB. Does being overweight really reduce mortality?. Obesity (Silver Spring). 2013;21(9):1746-1749. doi:10.1002/oby.20602 Heymsfield SB, Cefalu WT. Does Body Mass Index Adequately Convey a Patient's Mortality Risk? JAMA. 2013;309(1):87–88. doi:10.1001/jama.2012.185445 Gibbs W. Obesity: An Overblown Epidemic? . https://www.scientificamerican.com/article/obesity-an-overblown-epidemic-2006-12/ Web site. . Updated 2024. Accessed May 18, 2024 Humphreys S. The unethical use of BMI in contemporary general practice. Br J Gen Pract. 2010;60(578):696-697. doi:10.3399/bjgp10X515548 Luli M, Yeo G, Farrell E, et al. The implications of defining obesity as a disease: a report from the Association for the Study of Obesity 2021 annual conference. EClinicalMedicine. 2023;58:101962. Published 2023 Apr 6. doi:10.1016/j.eclinm.2023.101962 Tylka TL, Annunziato RA, Burgard D, et al. The weight-inclusive versus weight-normative approach to health: evaluating the evidence for prioritizing well-being over weight loss. J Obes. 2014;2014:983495. doi:10.1155/2014/983495

Assumere i farmaci per la pressione arteriosa nel momento giusto della giornata, in base al proprio ritmo sonno-veglia potrebbe ridurre il rischio di infarto. Questo è quanto evidenzia uno studio pubblicato sulla rivista eClinicalMedicine del gruppo Lancet che commentiamo a Obiettivo Salute con il dottor Filippo Pigazzani, Cardiologo e Senior Clinical Lecturer presso la Scuola di Medicina dell’Università di Dundee che ha coordinato la ricerca.

Andrew Yiu joins Claudia Schafer, Editor-in-Chief for eClinicalMedicine, to talk about his recent paper on adoption of routine surgical video recordings and future implications on policy and clinical practice.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00124-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

In the second episode of 2024 Dave and Mazz discuss interesting novel psychiatric interventions. Dave guides us through the promising and cost-effective arts-literacy intervention Pre-Texts in the Kenyan context, and Mazz takes us on a roller-coaster ride through the twists and turns of the development of the novel antipsychotic medication Ulotaront.The references for this episode are:Dave: Osborn TL, Ndetei DM, Sacco PL, Mutiso V, Sommer D. An arts-literacy intervention for adolescent depression and anxiety symptoms: outcomes of a randomised controlled trial of Pre-Texts with Kenyan adolescents. EClinicalMedicine. 2023 Nov 15;66:102288. doi: 10.1016/j.eclinm.2023.102288. PMID: 38192586; PMCID: PMC10772152.Mazz: Norman, TR, Olver JS. A challenge to the dopamine orthodoxy in schizophrenia? Australian & New Zealand Journal of Psychiatry. 2023, 57(9), 1198-1199. doi: 10.1177/00048674231177958.The Psych Review was brought to you by Call to Mind, a telepsychiatry service that you can learn more about at www.calltomind.com.au. The original music in our podcast was provided by the very talented John Badgery, and our logo was designed by the creative genius of Naz.

Welcome to Episode 34 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 34 of “The 2 View” – pertussis, computer interpretation of EKGs, TB, FQ side effects, and incidental findings Pertussis Best Practices for Healthcare Professionals on the Use of Polymerase Chain Reaction (PCR) for Diagnosing Pertussis. Pertussis: Use of PCR for diagnosis. Cdc.gov. Published January 12, 2023 https://www.cdc.gov/pertussis/clinical/diagnostic-testing/diagnosis-pcr-bestpractices.html Specimen Collection and Diagnostic Testing. Cdc.gov. Published October 11, 2023 https://www.cdc.gov/pertussis/clinical/diagnostic-testing/specimen-collection-diagnosis.html Treatment. Cdc.gov. Published September 16, 2022 https://www.cdc.gov/pertussis/clinical/treatment.html Computer Interpretation of EKGs Bracey A, Meyers HP, Smith SW. Emergency physicians should interpret every triage ECG, including those with a computer interpretation of “normal.” Am J Emerg Med. PubMed. National Library of Medicine: National Center for Biotechnology Information. Published May 2022 https://pubmed.ncbi.nlm.nih.gov/35361516/ Deutsch A, Poronsky K, Westafer L, Visintainer P, Mader T. Validity of Computer-interpreted “Normal” and “Otherwise Normal” ECG in Emergency Department Triage Patients. West J Emerg Med. PubMed. National Library of Medicine: National Center for Biotechnology Information. Published January 2024 https://pubmed.ncbi.nlm.nih.gov/38205978/ Tuberculosis CDCTB. TB Testing & Diagnosis. cdc.gov Published July 26, 2022 https://www.cdc.gov/tb/topic/testing/default.htm Global Tuberculosis Institute. Treating Latent TB Infection (LTBI). YouTube. Published November 29, 2022 https://www.youtube.com/watch?v=Udq-65YuLlo Niknejad M, Gaillard F. Tuberculosis (pulmonary manifestations). In: Radiopaedia.org. Radiopaedia.org; 2010. Revised January 5, 2024 https://radiopaedia.org/articles/tuberculosis-pulmonary-manifestations-1?lang=us Fluoroquinolone Antibiotic Side Effects Farkas J. PulmCrit - Six reasons to avoid fluoroquinolones in the critically ill. PulmCrit (EMCrit). Published August 1, 2016 https://emcrit.org/pulmcrit/fluoroquinolone-critical-illness/ FDA Drug Safety Podcast: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. U.S. fda.gov Published January 19, 2022 https://www.fda.gov/drugs/fda-drug-safety-podcasts/fda-drug-safety-podcast-fda-updates-warnings-oral-and-injectable-fluoroquinolone-antibiotics-due Highlights of Prescribing Information: CIPRO. fda.gov https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019537s086lbl.pdf Stanley I. Mother is left unable to walk after taking just three ANTIBIOTIC pills to treat a UTI: Disabled vet husband she previously cared for is also in a wheelchair. DailyMail.com. Published February 22, 2024 https://www.dailymail.co.uk/health/article-13111327/young-mother-unable-walk-antibiotic-pills-uti.html Tilley C. “Killer” antibiotic that's STILL being prescribed to 15m Americans a year: Widow of singer Bobby. DailyMail.com. Published March 2, 2024 https://www.dailymail.co.uk/health/article-13115607/Bobby-Caldwell-wife-fluoroquinolone-antibiotics.html Incidental Findings Incidental Findings. acr.org. American College of Radiology https://www.acr.org/Clinical-Resources/Incidental-Findings Schleicher S. DermDx: Suspicious Mole on Sole of Foot. Clinical Advisor. Published February 16, 2024 https://www.clinicaladvisor.com/slideshow/derm-dx/dermdx-suspicious-mole-foot/?elqtrack=True&hmemail=1f%2FJfEV7hN5vJr6vg%2FQRqK0NA6IXtyO3&hmsubid&nid=1639413404&sha256email=092493d8223fdfa40d9e995176d13e5fc5b5211674db9deb440c025fd462c80c Viennet M, Tapia S, Cottenet J, Bernard A, Ortega-Deballon P, Quantin C. Increased risk of colon cancer after acute appendicitis: a nationwide, population-based study. EClinicalMedicine. Published August 30, 2023 https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00373-5/fulltext Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Daniel Myran joins Hannah Linne, Senior Editor at eClinicalMedicine, to discuss the findings of their recent population-based cohort study investigating the risk of having an incident healthcare visit for an anxiety disorder following an emergency department visit for cannabis use.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00034-8/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial. Jensen, G. B., Domellöf, M., Ahlsson, F., Elfvin, A., Navér, L., & Abrahamsson, T. eClinicalMedicine (2023).As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Hello Friends, We have a new episode of journal club for you this week. On this episode Ben & Daphna review the latest research in neonatology, and welcome the EBNEO team for a new commentary. The articles reviewed this week include: Esophageal versus Rectal Temperature Monitoring during Whole-body Therapeutic Hypothermia for Hypoxic-ischemic Encephalopathy: Association with Short and Long-term Outcomes. Wu TW, Schmicker R, Wood TR, Mietzsch U, Comstock B, Heagerty PJ, Rao R, Gonzalez F, Juul S, Wu YW.J Pediatr. 2024 Feb 1:113933. doi: 10.1016/j.jpeds.2024.113933. Online ahead of print.PMID: 38309524 Free article.Neonatal Outcomes After COVID-19 Vaccination in Pregnancy. Norman M, Magnus MC, Söderling J, Juliusson PB, Navér L, Örtqvist AK, Håberg S, Stephansson O.JAMA. 2024 Feb 6;331(5):396-407. doi: 10.1001/jama.2023.26945.PMID: 38319332Maternal syphilis rates tripled in the US between 2016 and 2022, data show. Tanne JH.BMJ. 2024 Feb 15;384:q416. doi: 10.1136/bmj.q416.PMID: 38359912 No abstract available. Therapeutic hypothermia for preterm infants 34-35 weeks gestational age with neonatal encephalopathy. Kim SH, El-Shibiny H, Inder T, El-Dib M.J Perinatol. 2024 Jan 16. doi: 10.1038/s41372-024-01874-x. Online ahead of print.PMID: 38228763Randomised study of a new inline respiratory function monitor (Juno) to improve mask seal and delivered ventilation with neonatal manikins. Tracy MB, Hinder M, Morakeas S, Lowe K, Priyadarshi A, Crott M, Boustred M, Culcer M.Arch Dis Child Fetal Neonatal Ed. 2024 Feb 9:fetalneonatal-2023-326256. doi: 10.1136/archdischild-2023-326256. Online ahead of print.PMID: 38336472Dextrose gel prophylaxis for neonatal hypoglycaemia and neurocognitive function at early school age: a randomised dosage trial. Wei X, Franke N, Alsweiler JM, Brown GTL, Gamble GD, McNeill A, Rogers J, Thompson B, Turuwhenua J, Wouldes TA, Harding JE, McKinlay CJD; pre-hPOD Early School-age Outcomes Study Group.Arch Dis Child Fetal Neonatal Ed. 2024 Feb 12:fetalneonatal-2023-326452. doi: 10.1136/archdischild-2023-326452. Online ahead of print.PMID: 38307710Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial. Jensen, G. B., Domellöf, M., Ahlsson, F., Elfvin, A., Navér, L., & Abrahamsson, T. eClinicalMedicine (2023).Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial. Colaizy TT, Poindexter BB, McDonald SA, et al. JAMA. 2024;331(7):582–591. doi:10.1001/jama.2023.27693EBNEO Commentary: De-MIST-ifying the 2-year outcomes of non-invasive surfactant therapy. Loft L, Ferguson KN, Tingay DG. Acta Paediatr. 2024 Jan 25. doi: 10.1111/apa.17116. O As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

As an adult, there's a good chance you've experienced moments when your brain feels foggy or you struggle to concentrate. This phenomenon, commonly known as "fuzzy brain" or "brain fog," can be frustrating and impact your daily life. But what causes these symptoms, and are there solutions to combat them? In this article, we will delve into the causes of fuzzy brain symptoms and explore solutions to enhance your clarity and cognitive function. So, if you have ever wondered why your brain always feels foggy, keep reading to gain a better understanding of this condition and how to address it. What is Fuzzy Brain or Brain Fog? "Fuzzy brain," commonly referred to as "brain fog," is not a medical condition in itself but a term used to describe a set of symptoms affecting cognitive abilities. People experiencing brain fog may feel confused, disorganized, and have difficulty focusing, putting thoughts into words, or remembering things. This cognitive dysfunction is characterized by memory problems, lack of mental clarity, poor concentration, and an inability to focus, often described as mental fatigue. Common Signs and Symptoms Brain fog, often described as "fuzzy brain," is characterized by a constellation of symptoms related to cognitive dysfunction, including confusion, memory problems, lack of mental clarity, poor concentration, and the inability to focus. While the term "brain fog" is not always used explicitly in scientific literature, the symptoms it encompasses are well-documented in studies related to cognitive function and mental health. Below are the most common symptoms: Cognitive Impairment and Memory Problems: Cognitive dysfunction, including memory lapses and difficulties with recall, is a hallmark of brain fog. A study by Banks, S. et al. (2020) on sleep deprivation highlights how lack of sleep—a common contributor to brain fog—can impair memory and cognitive performance, simulating the symptoms of brain fog.Banks, S., Van Dongen, H. P. A., Maislin, G., & Dinges, D. F. (2010). Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. Sleep, 33(8), 1013–1026. Lack of Mental Clarity and Poor Concentration: People experiencing brain fog often report a lack of mental clarity and difficulty concentrating.Gavelin, H. M., Neumann, S., Kovacs, A. H., Malmberg, F., Malmberg, J., Bonde, A. H., ... & Wicksell, R. K. (2021). Cognitive impairments in individuals with long COVID: A 6-month follow-up study. EClinicalMedicine, 41, 101159. Feeling of Mental Fatigue: Mental fatigue is another symptom frequently associated with brain fog. This encompasses a subjective sense of tiredness and a lack of energy for mental tasks.Marcora, S. M., Staiano, W., & Manning, V. (2009). Mental fatigue impairs physical performance in humans. Journal of Applied Physiology, 106(3), 857–864. Difficulty Stringing Thoughts Together: People with brain fog often describe a sensation of struggling to string thoughts together, leading to difficulties with speech or articulating ideas. This symptom points towards an impairment in executive function, which is crucial for planning, decision-making, and verbal fluency.Diamond, A. (2013). Executive functions. Annual Review of Psychology, 64, 135–168. Disrupted Executive Function: Executive dysfunction, including difficulty planning, organizing, and multitasking, is often reported in the context of brain fog. Such symptoms can stem from various conditions, including chronic stress and poor sleep. Stress can alter executive functions, leading to decreased cognitive flexibility and increased rigidity in thoughts and actions.Arnsten, A. F. T. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience, 10(6), 410–422. These symptoms collectively contribute to the subjective experience of brain fog, making daily cognitive tasks more challenging and impacting ove...

37. Injectable Vs. Sublingual Buprenorphine In episode 37 we discuss an article comparing injectable and sublingual buprenorphine. Superiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial. Marsden, John et al. eClinicalMedicine, Volume 66, 102311  We also discuss new data on the teratogenicity of fentanyl, and a new genetic test to identify the risk for opioid use disorder. Genetics on Medicine Open: A novel syndrome associated with prenatal fentanyl exposure FDA: FDA Approves First Test to Help Identify Elevated Risk of Developing Opioid Use Disorder ---------- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, please visit MI CARES. ---------- Episode 37 Credits: Original theme music: composed and performed by Benjamin Kennedy Audio production: Erin McCue Executive Producer: Dr. Patrick Beeman A podcast from Ars Longa Media ---------- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. Email: addictionmedicinejournalclub@gmail.com  Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC  Threads: @AddictionMedJC Twitter/X: @AddictionMedJC   YouTube: addictionmedicinejournalclub Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Ben Burwood (Senior Editor) sits down with Charlotte Rowbottom (Senior Editor), Vincenzo Giacco (Senior Editor), and Claudia Schaefer (Editor-in-Chief) to discuss 2023 and what lies ahead for the journal in 2024. The team discuss a paper on genetically and environmentally predicted obesity; an upcoming Article on using deep-learning and ECGs to predict risk of type 2 diabetes; eClinicalMedicine's 2023 obesity collection; four upcoming Series on Cancer care in Children and in Asia, meaningful outcomes in cancer care, and cancer care in England and Wales; and lastly, what we look for as editors when reviewing manuscripts.Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Welcome back to another episode of The Mama Village! I am your host, Ellen and today I sit down with the incredible Kirstie, a mother to a beautiful 2 year old son and soon to be mama of two, with another little one soon joining the family. In this episode, Kirstie shares her profound homebirth experience with a private midwife. This is a story of complete trust, surrender and love. Throughout Kirstie's labour, her baby turned and made his grand entrance into the world in a breech position, adding an extra layer of intensity to her already remarkable story. As Kirstie takes us through her spiritual journey into the rebirth of herself as a mother, we explore the importance of breath work for her labour and to bring back to the present moment. This episode is a beacon of inspiration for all mothers emphasising the strength found within the vulnerability and the deep connection between mind, body and spirit during childbirth.   Kirstie also bravely shares her raw and honest reality of her postpartum struggles, providing a glimpse into the challenges many mothers face but often go unspoken. Her journey extends into a vision for the future, she shares her aspirations to support and guide other women through their postpartum experiences, fostering community where self-love and understanding prevail. Don't forget that if you like the show, please subscribe and leave a review on your podcast platform as this helps get these positive stories and education out there to women throughout Australia and the world. If you would like to share your positive pregnancy, birth, postpartum and motherhood story, or if you are an expert in the field, please send an email to the.mamavillage@outlook.com   Instagram: @the.mamavillage Email: the.mamavillage@outlook.com For Music: https://soundcloud.com/emotionetoile/kevin-macleod-easy-day-no-copyright-music-103 Disclaimer: I am not a medical professional, and this is not medical advice. Any information discussed in this podcast should notreplace the advice of your professional healthcare provider. This podcast is designed for general information only and is not specific to individual needs. Please seek advice from your professional health care provider if you have any concerns regarding your pregnancy, birth or postpartum. Resources: Scarf, V. L., Rossiter, C., Vedam, S., Dahlen, H. G., Ellwood, D., Forster, D., Foureur, M. J., McLachlan, H., Oats, J., Sibbritt, D., Thornton, C., & Homer, C. S. E. (2018). Maternal and perinatal outcomes by planned place of birth among women with low-risk pregnancies in high-income countries: A systematic review and meta-analysis. Midwifery, 62(62), 240–255. https://doi.org/10.1016/j.midw.2018.03.024 Reitsma, A., Simioni, J., Brunton, G., Kaufman, K., & Hutton, E. K. (2020). Maternal Outcomes and Birth Interventions among Women Who Begin Labour Intending to Give Birth at Home Compared to Women of Low Obstetrical Risk Who Intend to Give Birth in hospital: a Systematic Review and meta-analyses. EClinicalMedicine, 21(100319), 100319. https://doi.org/10.1016/j.eclinm.2020.100319 Olsen, O., & Clausen, J. (2023, March 8). Planned hospital birth versus planned home birth. Www.cochrane.org. https://www.cochrane.org/CD000352/PREG_planned-hospital-birth-versus-planned-home-birth

Este podcast está presentado por los médicos neonatólogos Dani de Luis Rosell, Elena Itriago, Carolina Michel y Juliana Castellanos; nuestras futuras doctoras Valentina Giraldo y Laura Molina y su anfitriona Maria Flores Cordova, médico residente de pediatría. No dudes en enviarnos preguntas, comentarios o sugerencias a nuestro correo electrónico: nicupodcast@gmail.comLos artículos que se tratan en el episodio de hoy están listados aquí: Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators.N Engl J Med. 2023 Mar 16;388(11):980-990. doi: 10.1056/NEJMoa2207418. Epub 2022 Dec 6.Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants.Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group.N Engl J Med. 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275.Antenatal dexamethasone for late preterm birth: A multi-centre, two-arm, parallel, double-blind, placebo-controlled, randomized trial.WHO ACTION Trials Collaborators.EClinicalMedicine. 2022 Feb 12;44:101285. doi: 10.1016/j.eclinm.2022.101285. eCollection 2022 Feb.Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium.N Engl J Med. 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. Bienvenidos a La Incubadora: una conversación sobre neonatología y medicina basada en evidencia. Nuestros episodios ofrecen la dosis ideal (en mg/kg) de los más recientes avances para el neonato y para las increíbles personas que forman parte de la medicina neonatal. Soy tu host, Maria Flores Cordova, MD. Presentado por los Neonatólogos Elena Itriago MD, Dani de Luis Rosell MD, Carolina Michel MD, las futuras doctoras Marla Fortoul, Valentina Giraldo, Laura Molina. Creado originalmente por Ben Courchia MD y Daphna Yasova Barbeau MD http://www.the-incubator.org

A percentagem de pessoas que morreram em casa aumentou em 23 países durante a pandemia de Covid-19, revela um estudo internacional que analisou dados de 32 países. Durante a pandemia, os sistemas de saúde tiveram que responder às necessidades dos pacientes com COVID-19, ao mesmo tempo que cuidavam de pacientes com outras doenças fatais. A percentagem de pessoas que morreram em casa aumentou em 23 dos 32 países, revela o estudo desenvolvido no âmbito do projecto de investigação EOLinPLACE: Escolha onde morreremos: uma reforma de classificação para discernir a diversidade nos caminhos individuais de fim de vida.O estudo foi realizado por quatro equipas de investigação em Portugal, Holanda, Estados Unidos e Uganda e consistiu "numa analise de dados de certificado de óbitos com informação sobre o local onde as pessoas morrem", descreve a investigadora da Faculdade de Medicina da Universidade de Coimbra, Bárbara Gomes, que liderou a equipa portuguesa que integra o projecto EOLinPLace. "Nós recolhemos a informação em 32 países, com financiamento do Conselho Europeu de investigação que nos permitiu obter e trabalhar esses dados durante uma década - desde 2012 até 2021 - incluímos os dois anos da pandemia", acrescenta a investigadora."Este é o maior estudo de tendências internacionais no local de morte e é o primeiro a mostrar o impacto de pandemia. Na maioria dos países foi registado um aumento da morte em casa. Isto é importante porque representa uma mudança nunca antes vista nos cuidados prestados em fim de vida, no sentido de ser um retorno a morrer em casa. Antes da pandemia, já sabíamos que existia uma tendência crescente nalguns destes países, como o Reino Unido e os Estados Unidos. Agora sabemos que há mais países em que essa tendência já se verificava antes da pandemia. Durante os anos da pandemia foi notório esse aumento de percentagem de pessoas que morreu em casa", realça a investigadora da Faculdade de Medicina da Universidade de Coimbra. "O Uganda foi o único país africano [a participar no projecto] e é um dos países alvo do projecto onde este estudo de insere, que é o projecto OLinPLACE. Neste projecto temos quatro países que fazem parte destes 32 que analisamos - Portugal, Holanda, Estados Unidos e Uganda. Escolhemos estes países porque sabemos que são bastante contrastantes. No Uganda verificamos a taxa mais elevada de morte em casa de todos os países entre os 76 e 82%, antes da pandemia. Verificamos que foi um dos países onde essa percentagem mais diminuiu, ao contrário da tendência dos outros países", concluiu a investigadora Bárbara Gomes.O artigo científico O aumento da mortalidade domiciliar na pandemia de COVID-19: um estudo de base populacional de dados de certidões de óbito para adultos de 32 países, 2012-2021 foi publicado na revista eClinicalMedicine, editada pela revista The Lancet.

STUDIES REVIEWED THIS WEEK:   Chang R et al. Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study. EClinicalMedicine. 2023 Feb;56:101783   Tesch F et al. Incident autoimmune diseases in association with SARS-CoV-2 infection: a matched cohort study. Clin Rheumatol. 2023 Oct;42(10):2905-2914.    Lim SG et al. Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19  JAMA Netw Open. 2023 Oct 2;6(10):e2336120.     Pastukhova E et al. Alopecia Areata as a Sequela of COVID-19 Vaccination: A Systematic Review J Cutan Med Surg. 2023 Jan-Feb;27(1):64-65.     STUDIES TO BE REVIEWED NEXT WEEK (PREVIEW) Wang C-W et al. Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations. Clin Immunol. 2023 Oct:255:109737.   Genco L et al.  Alopecia Areata after COVID-19 Vaccines. Skin Appendage Disord. 2023 Mar;9(2):141-143.

Giulia Vivaldi joins Charlotte Rowbottom, Senior Editor at eClinicalMedicine, to discuss the findings of her recent COVIDENCE UK study comparing the long-term symptoms of COVID-19 with that of other types of acute respiratory infection.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2823%2900428-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor Gary Darmstadt joins Elena Bellafante, Deputy Editor at eClinicalMedicine, to discuss the new WHO recommendations and research priorities for care of preterm or low birthweight infants.Read the full Series here:https://www.thelancet.com/series/Preterm-LBW-care?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Incidence of football injuries sustained on artificial turf compared to grass and other playing surfaces: a systematic review and meta-analysis. Kuitunen I, Immonen V, Pakarinen O, et al. EClinicalMedicine. 2023;59:101956. doi:10.1016/j.eclinm.2023.101956 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest Physio Network–https://www.physio-network.com/ Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight

Tobias Schiffler, Medical University of Vienna, sits down with Ben Burwood, Senior Editor at eClinicalMedicine, to discuss the findings of the CANCERLESS project, which is looking to improve access to cancer care for people who have experienced homelessness.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00272-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Die Themen in den Wissensnachrichten: +++ Stereoskopische Aufnahmen bringen Figuren in spanischer Höhlenmalerei zum Vorschein +++ Pro betrieblicher Gleichstellungs-Maßnahme sinkt der Gender Pay Gap um 2,5 Prozent +++ Wie sich in Wasser schreiben lässt +++**********Weiterführende Quellen zu dieser Folge:Animals hidden in plain sight: stereoscopic recording of Palaeolithic rock art at La Pasiega cave, Cantabria. Antiquity, 17.08.2023In Betrieben mit Gleichstellungsmaßnahmen ist die Verdienstlücke kleiner. IAB-Kurzbericht, 22.08.2023Writing Into Water. Small, 21.08.2023Generative AI and Jobs: A global analysis of potential effects on job quantity and quality. ILO Working Paper, 21.08.2023Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort. eClinicalMedicine, 18.08.2023Large positive ecological changes of small urban greening actions. Ecological Solutions and Evidence, 21.08.2023**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.**********Weitere Wissensnachrichten zum Nachlesen: https://www.deutschlandfunknova.de/nachrichten

Dr Bishal Gyawali joins Claudia Schaefer, Editor-in-Chief eClinicalMedicine, to celebrate the 5 year anniversary of the journal by looking back at the most prominent papers and looking forward highlighting important projects to come. Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Dr Hanna Creese joins Elena Bellafante, Deputy Editor at eClinicalMedicine, to discuss the role of body-image and self-esteem in the relationship between mental health and body-mass index in adolescents.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00169-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Chris Han joins Charlotte Rowbottom, Senior Editor at eClinicalMedicine, to discuss the prevalence of low back pain and their research into whether it is possible to reliably locate the source of such pain.Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00137-2/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinmContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Wiele uwagi poświęca się związkowi pomiędzy podłożem genetycznym a czynnikami środowiskowymi i ich wpływowi na funkcjonowanie organizmu. Zjawiska epigenetycznie i zajmująca się nimi nauka – epigenetyka, są swojego rodzaju łącznikiem pomiędzy naszymi genami, a czynnikami środowiskowymi. Zmiany epigenetyczne mogą być związane zarówno z procesami fizjologicznymi, jak i patologicznymi. Dlatego są one obecnie rozważane jako istotny patomechanizm schorzeń jak nowotwory, choroby sercowo-naczyniowe, choroby neurodegeneracyjne, czy choroby zapalne jelit. Gość: dr n. biol. Dorota Komar. Dorota jest doktorka genetyki i biologii rozwoju ze specjalizacją w epigenetycy. Dorotę znajdziecie na Instagramie na którym popularyzuję wiedzę naukową @darwininchaneldress. W odcinku znajdziesz m. in. odpowiedzi na następujące pytania: Czym jest epigenetyka i modyfikacje epigenetyczne? Dlaczego komórki naszego ciała są różne mimo, że mają ten sam genom? Dlaczego owady społeczne to superorganizm? Czym jest potworniak? Czy możemy dziedziczyć cechy nabyte? Czy układ odpornościowy jest dziedziczny czy bardziej zależy od czynników środowiskowych? Czym jest wytrenowana odporność? Czy pociąg do drugiej osoby zależy od naszego układu odpornościowego? Czy rośliny mają układ odpornościowy? Czym jest zegar epigenetyczny i co ma wspólnego ze starzeniem się? Czy możemy odmłodzić nasz układ odpornościowy? Jak powstaje nowotwór i co ma z tym wspólnego epigenetyka?  Lista publikacji o których wspominamy w podcaście: Dolinoy D.C. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev. 2008 Aug;66 Suppl 1(Suppl 1):S7-11. Dias B.G i Ressler K.J. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci. 2014 Jan;17(1):89-96. Brodin P. i wsp. Variation in the human immune system is largely driven by non-heritable influences. Cell. 2015 Jan 15;160(1-2):37-47 Liston A. i wsp. Shaping Variation in the Human Immune System. Trends Immunol. 2016 Oct;37(10):637-646 Mangino M. i wsp. Innate and adaptive immune traits are differentially affected by genetic and environmental factors. Nat Commun. 2017 Jan 5;8:13850 Leentjens J. i wsp. Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis. Circ Res. 2018 Mar 2;122(5):664-669. Katzmarski N. i wsp. Transmission of trained immunity and heterologous resistance to infections across generations. Nat Immunol. 2021 Nov;22(11):1382-1390. Rechavi O. i wsp. Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans. Cell. 2011 Dec 9;147(6):1248-56. Cheung P. i wsp. Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell. 2018 May 31;173(6):1385-1397.e14. Fahy G.M. i wsp. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019 Dec;18(6):e13028. Quach, A. i wsp. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging 2017, 9, 419–446. Anderson O.S. i wsp. Epigenetic Responses Following Maternal Dietary Exposure to Physiologically Relevant Levels of Bisphenol A. Environ Mol Mutagen. 2012 Jun; 53(5): 334–342. https://www.eoht.info/page/Sweaty%20T-shirt%20study Berendsen Mi. i wsp. Parental Bacillus Calmette-Guérin vaccine scars decrease infant mortality in the first six weeks of life: A retrospective cohort study. EClinicalMedicine. 2021 Aug 12;39:101049. Gee S. i wsp. The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate. Nat Immunol. 2021 Dec;22(12):1490-1502 Fitzgerald i wsp. Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series. Aging (Albany NY) . 2023 Mar 22;15(6):1833-1839.

Low back pain of disc, sacroiliac joint, or facet joint origin: a diagnostic accuracy systematic review. Han CS, Hancock MJ, Sharma S, et al. eClinicalMedicine. 2023;59:101960. doi:10.1016/j.eclinm.2023.101960 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight

Dr Sally Abbott and Dr Stuart Flint join Hannah Linne, Senior Editor at eClinicalMedicine, to discuss the prevalence and impact of weight bias in health care as part of eClinicalMedicine's special collection on obesity.Read the full articles here:“Is it time to throw out the weighing scales?” Implicit weight bias among healthcare professionals working in bariatric surgery services and their attitude towards non-weight focused approaches - eClinicalMedicine (thelancet.com)Effect of health-care professionals' weight status on patient satisfaction and recalled advice: a prospective cohort study - eClinicalMedicine (thelancet.com)Pervasiveness, impact and implications of weight stigma - eClinicalMedicine (thelancet.com)Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Today I had the pleasure of speaking with Dr Emily MacLean about the exciting modern tests both commercially available and in research development for diagnosing tuberculosis. Emily talked to us about how GeneXpert has evolved and how we can get the most out of this amazing test but also about the extraordinary diagnostic tests being investigated at the moment from blood tests of host response to bacilli to AI learning cough acoustic markers of tuberculosis!REFERENCES:MacLean, Emily, et al. "Diagnostic accuracy of stool Xpert MTB/RIF for detection of pulmonary tuberculosis in children: a systematic review and meta-analysis." Journal of clinical microbiology 57.6 (2019): e02057-18.Singhroy, Diane N., et al. "Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers." Gates open research 4 (2020).MacLean, Emily Lai-Ho, et al. "Integrating tuberculosis and COVID-19 molecular testing in Lima, Peru: a cross-sectional, diagnostic accuracy study." The Lancet Microbe (2023).Zifodya, Jerry S., et al. "Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis." Cochrane Database of Systematic Reviews 2 (2021).APA | Mishra, Hridesh, et al. "Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study." The Lancet Respiratory Medicine 8.4 (2020): 368-382.APA | Kohli, Mikashmi, et al. "Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults." Cochrane Database of Systematic Reviews 1 (2021).APA | Branigan D. Tuberculosis Diagnostics. Nov 2022. Available at:https://www.treatmentactiongroup.org/wp-content/uploads/2022/11/pipeline_TB_diagnostics_2022.pdfMacLean, Emily, et al. "Advances in molecular diagnosis of tuberculosis." Journal of clinical microbiology 58.10 (2020): e01582-19.Sweeney, Timothy E., et al. "Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis." The Lancet Respiratory Medicine 4.3 (2016): 213-224.Sutherland, Jayne S., et al. "Diagnostic accuracy of the Cepheid 3-gene host response fingerstick blood test in a prospective, multi-site study: interim results." Clinical Infectious Diseases 74.12 (2022): 2136-2141.Moreira, Flora Martinez Figueira, et al. "Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study." EClinicalMedicine 33 (2021): 100776.Peter, Jonny G., et al. "Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial." The Lancet 387.10024 (2016): 1187-1197.

Sarah Le Brocq and Juan Pablo Villaseñor Díaz join Hannah Linne, Senior Editor at eClinicalMedicine, to discuss their experiences of living with overweight and obesity as part of eClinicalMedicine's special collection on obesity.Read the full articles here:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00378-9/fulltexthttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00377-7/fulltext#%20Continue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Confronting the evolution and expansion of anti-vaccine activism (The Lancet)  Effectiveness of maternal influenza vaccination in Peru (OFID) Characteristics and predictors of persistent symptoms post-COVID-19 (BMJ) Parental nonadherence to health policy recommendations for prevention of COVID-19 (JAMA) Community-onset bacterial coinfection in children ill with SARS-CoV-2 infection (OFID) Bivalent booster effectiveness against severe COVID-19 outcomes (medRxiv)  Viral kinetics of sequential SARS-CoV-2 infections (medRxiv) Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID) Immunomodulators for severe COVID-19 in transplant patients (TID) Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population (eClinicalMedicine)  Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection (BMJ) One year adverse outcomes among US adults with post COVID-19 condition vs those without COVID-19 (JAMA) Long-term gastrointestinal outcomes of COVID-19 (Nature) Contribute to our ASTMH fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 990 Don't crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Dr Kiara Chang joins eClinicalMedicine to discuss the link between ultra-processed food consumption and cancer risk and cancer-related mortality.Read the full article:Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK BiobankContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Professor Alasdair MacGowan joins Charlotte Rowbottom, Senior Editor at eClinicalMedicine, to discuss treatment options for skin infections caused by MRSA, antimicrobial stewardship, and their research comparing the safety and efficacy of two therapeutic regimens.Read the full article:Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: the AIDA open label, randomized, controlled phase 4 trialContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

In this episode, eClinicalMedicine highlights the Gender Equality and Health collection to renew the call for action for a gender equitable society in the aftermath of the COVID-19 pandemic, which exacerbated the unequal value and treatment of women worldwide.Read the collection:Gender and the COVID-19 pandemic: Multinational research indicate that we must support and compensate LMIC women's leadership in crisesGender differences in work attendance among health care workers in Northern Nigeria during the COVID-19 pandemicSpousal support and work performance during the COVID-19 pandemic among elected women representatives in rural Bihar, India

Dr Valeria Frighi joins Claudia Schafer, Editor-in-Chief for eClinicalMedicine, to discuss the risk of major osteoporotic fractures in people with intellectual disabilities.Read the full article:Incidence of fractures in people with intellectual disabilities over the life course: a retrospective matched cohort study

We usually think nightmares are problems that interrupt the sleep of children. But half to 85 percent of adults have nightmares too. About 1 in 20 adults report experiencing them every week. In a new study published in the journal eClinicalMedicine, U.K. researchers observed that adults between 35 and 64 years old who experienced distressing […] The post 294. Nightmares during middle age linked to risk of dementia appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

Uno studio dell'Università di Birmingham pubblicato su eClinicalMedicine e condotto su oltre 3.800 uomini anziani mette in relazione la qualità del sonno con la salute del cervello. A Obiettivo Salute il commento del prof. Alberto Albanese, responsabile di Neurologia dell'Humanitas e docente all'Humanitas University di Milano.

mit Dr. Sarah Schwitalla Ein täglicher wachsender gigantischer Probiotika-Markt, bis 2024 allein in USA prognostiziert auf 66 Milliarden USD, macht die richtige Wahl zu einer großen Challenge für jeden, der eines aus dem unendlichen Angebot auswählen möchte und für jeden Behandler und Therapeuten, der seinen Patienten eines empfehlen will – welches davon ist wirksam? Am Ende geben Menschen viel Geld aus und spüren dabei aber oft keine Verbesserung in dem Maße wie erhofft. Zusätzlich zu Bauchschmerzen, Verdauungsproblemen und anderen Symptomen schränken ggfs sogar Nebenwirkungen, wachsende Frustration und ein Loch im Geldbeutel die Lebensqualität weiter stark ein. In meiner heutigen Episode bespreche ich ob Probiotika bei Reizdarmsyndrom wirksam sind - was sagen Studien? Ich gebe außerdem wertvolle Empfehlungen und Hinweise welcher Behandlungsansatz beim Reizdarm (individuell nach Subtyp anpassbar) Erfolge zeigen kann: - Warum ist Reizdarmsyndrom eine ganzheitliche Erkrankung? - Welche Probiotika sind wirksam bei Reizdarm? - Warum zeigen die meisten Probiotika keine oder geringe Wirksamkeit? - Meine Empfehlungen - Welche Alternativen zu Probiotika gibt es Reizdarmsyndrom zu behandeln? HIER zur Warteliste für die wissenschaftlich basierte Fortbildung „Mikrobiom Akademie 2022 (im Herbst) anmelden: [https://drschwitalla.ac-page.com/darmzentrum-warteliste](https://drschwitalla.ac-page.com/darmzentrum-warteliste) HIER zum Gratis Email Kurs „Verdauung verbessern und Mikrobiom ganzheitlich aufbauen“ [https://bit.ly/3U80kNk](https://bit.ly/3U80kNk) Podcast Episode “Blähbauch und Dysbiose verbessern”: [https://youtu.be/RUahUi631V4](https://youtu.be/RUahUi631V4) Infos - McFarland L V, Karakan T, Karatas A. Strain-specific and outcome-specific efficacy of probiotics for the treatment of irritable bowel syndrome: A systematic review and meta-analysis. *EClinicalMedicine* . 2021;41:101154. doi:10.1016/j.eclinm.2021.101154 - Probiotika mit Effekt zur Verbesserung von Bauchschmerzen: B. coagulans MTCC5260, L. plantarum 299v, S. boulardii CNCMI- 745 and S. cerevisiae CNCM I-3856 - Probiotika mit Effekt zur Verbesserung der gesamten Symptome bei Reizdarm: Bif. infantis 35624, Bac. coagulans MTCC5260 --- WISSENSCHAFT - DARMGESUNDHEIT - PRÄVENTION [https://drschwitalla.com](https://drschwitalla.com/) Kontakt & Anfragen: [https://drschwitalla.com/kontakt/](https://drschwitalla.com/kontakt/)

Damilola Shobiye and Ayomide Omotola join eClinicalMedicine to discuss trends in infant mortality in Nigeria, and the contributing factors for the high mortality rates observed in their recent study. Read the full article:Trends in infant mortality in Nigeria 

Dr Morteza Mahmoudi joins Dr Vincenzo Giacco, Senior Editor at eClinicalMedicine, to discuss bullying in academia across scientific disciplines, and how to tackle this important issue.Read the full Comment:The need for the development of discipline-specific approaches to address academic bullying

Dr Abidemi Otaiku joins Hannah Linne, Senior Editor at eClinicalMedicine, to discuss how frequent distressing dreams might be a prodromal symptom of Parkinson's disease, and the potential importance of this symptom in the disease course.Read the full article:Distressing dreams and risk of Parkinson's disease: A population-based cohort study

Videos: 1. Jonathan Pie: ‘Boris Johnson Is a Liar' | NYT Opinion (7:42) 2.  Dr Gabor Maté Leaves the Audience SPEECHLESS | One of the Best Speeches Ever (10:36) Zinc found to play an important role in lung fibrosis Cedars-Sinai Medical Center, June 8, 2022 Investigators from the Women's Guild Lung Institute at Cedars-Sinai have discovered that zinc, a common mineral, may reverse lung damage and improve survival for patients with a deadly age-related condition known as idiopathic pulmonary fibrosis (IPF).”This study has the potential to be a game changer,” said Paul Noble, MD, chair of the Department of Medicine. “We identified a root cause of IPF-related lung damage and a potential therapeutic target that might restore the lungs' ability to heal themselves.” Idiopathic pulmonary fibrosis, or IPF, affects 100,000 people in the U.S. and has no known cause. The condition, which leads to scarring of the lungs, called fibrosis, and progressive breathing difficulty, has no cure, and most patients die or require a lung transplant within three to five years of diagnosis. The incidence of IPF rises dramatically with age and affects men more often than women. (NEXT) Do optimists live longer? Harvard School of Public Health, June 8, 2022 In a study published in the Journal of the American Geriatrics Society that included a racially diverse group of 159,255 women, higher levels of optimism were associated with longer lifespans and a greater likelihood of living past 90 years of age. Investigators found that the link between optimism and longevity was evident across racial and ethnic groups, and that lifestyle factors accounted for nearly one-quarter of the optimism-lifespan association.  (NEXT) Sweet cherry anthocyanins support liver health… for rats at least Zhei-Jang University (China), June 1, 2022 Anthocyanins from sweet cherries may protect against diet-induced liver steatosis, or excessive amounts of fat in the liver's tissue, says a new study with rats.  The study, published in the journal Nutrition, built upon the abundant existing literature on the beneficial role anthocyanins have as an antioxidative, anti-inflammatory, and anti-hyperlipidemic component. Specifically, the cyanidin-3-glucoside variant “[has] been reported to ameliorate hepatic steatosis and adipose inflammation,” the researchers wrote. The condition known as liver steatosis is a common non-alcoholic fatty liver disease usually treated with drugs, but according to the researchers, some drug used for treatment “are usually accompanied by some adverse effect.” For 15 weeks, the researchers investigated the effects of sweet cherry anthocyanin supplementation have on alleviating high-fat diet-induced liver steatosis in rodents to explore the possibility of a none-drug treatment for the liver condition. According to the researchers, the results demonstrated how sweet cherry anthocyanins may be developed into a supplement to “protect from high-fat diet-induced hepatic steatosis in mice,”leading to a suggested potential for the anthocyanin's application in the “treatment of hepatic steatosis and other obesity related metabolic disorders.” (NEXT) Bad dreams could be early warning of Parkinson's disease University of Birmingham, June 8, 2022 Older adults who start to experience bad dreams or nightmares could be exhibiting the earliest signs of Parkinson's disease, say researchers at the University of Birmingham. A new study, published in eClinicalMedicine, showed that in a cohort of older men, individuals experiencing frequent bad dreams were twice as likely to be later diagnosed with Parkinson's as those who did not.Previous studies have shown that people with Parkinson's disease experience nightmares and bad dreams more frequently than adults in the general population, but using nightmares as a risk indicator for Parkinson's has not previously been considered.”While we need to carry out further research in this area, identifying the significance of bad dreams and nightmares could indicate that individuals who experience changes to their dreams in older age—without any obvious trigger—should seek medical advice.” The team used data from a large cohort study from the U.S., which contained data over a period of 12 years from 3818 older men living independently.  Participants reporting bad dreams at least once per week were then followed up at the end of the study to see whether they were more likely to be diagnosed with Parkinson's disease. (NEXT) Beetroot boosts sporting performance in athletes University of South Australia, June 8, 2022 Evaluating the performance effects of foods that are thought to have a beneficial effect on aerobic performance, researchers found that beetroot, grapes, sour cherries, and pine bark extract, which contribute to nitric oxide availability in the body, boost endurance exercise performance. Assessing data from 118 studies involving 1,872 participants from 25 different countries, the meta-analysis evaluated the effect of consuming nitrate-rich foods (typically green leafy vegetables), foods that contain polyphenols (such as berries, cherries and cocoa), and L-Citrulline (found in watermelon) on exercise endurance performance. The study, published in the Journal of the International Society of Sports Nutrition, found that the nitrate levels contained in beetroot, which have been shown to boost blood flow and increase the delivery of nutrients and oxygen to muscles during exercise, helped athletes perform better more quickly.

Dr James Kite joins Arianna Colosio, Deputy Editor at eClinicalMedicine, to discuss the role of mass media in weight stigmatisation, and how this influences attitudes towards people with overweight or obesity.Read the full article:Influence and effects of weight stigmatisation in media: a systematic review

Professor Johannes van Goudoever and Dr Britt van Keulen join Hannah Linne, Senior Editor at eClinicalMedicine, to discuss the role of human breast milk in infant immunity, and their research focusing on comparing breast milk antibody responses after vaccination with four different COVID-19 vaccines.Read the full article:Comparing the human milk antibody response after vaccination with four COVID-19 vaccines: A prospective, longitudinal cohort study in the Netherlands

Fiona Alderdice joins eClinicalMedicine to discuss anxiety and post-traumatic stress among the parents of babies admitted to neonatal units.Read the full article:Prevalence of anxiety and post-traumatic stress (PTS) among the parents of babies admitted to neonatal units: A systematic review and meta-analysis

Prasad Kulkarni, Medical Director of the Serum Institute of India, discusses his recent phase 2/3 trial on the Covishield vaccine published in eClinicalMedicine, as well as its implications for COVID vaccine development in general. 

Ett avsnitt om hemfödsel utifrån forskning och evidens med barnmorskan Liisa Svensson som är väl insatt i ämnet.  Om att visa intresse för kvinnornas kunskap, titta på evidens och låta de födande bestämma var och hur de önskar föda. Nu benar vi ut det här med hemfödsel utifrån forskning och evidens en gång för alla. För det finns otroligt mycket forskning gjord just på hemfödslar på flera håll världen över. Sammanfattningsvis: det är lika säkert för förstföderskor att föda hemma som på sjukhus, och det är t.o.m säkrare för omföderskor att föda hemma än på sjukhus. Självklart gäller detta vissa grupper.  (Vid ca 24 min är det omföderskor i gruppen som Liisa pratar om, inte förstföderskor)   Länkar till forskning: - Reitsma, A., Simioni, J., Brunton, G., Kaufman, K. & Hutton, E. (2020) Maternal outcomes and birth interventions among women who begin labour intending to give birth at home compared to women of low obstetrical risk who intend to give birth in hospital: A systematic review and meta-analyses. EClinicalMedicine, Vol.21. DOI: https://doi.org/10.1016/j.eclinm.2020.100319  -Hutton, E., Reitsma, A., Simioni, J., Brunton, G., & Kaufman, K. (2019) Perinatal or neonatal mortality among women who intend at the onset of labour to give birth at home compared to women of low obstetrical risk who intend to give birth in hospital: A systematic review and meta-analyses. EClinicalMedicine, Vol.14. DOI: https://doi.org/10.1016/j.eclinm.2019.07.005 -Bolten, N., de Jonge, A., Zwagerman, E., Zwagerman, P., Klomp, T., Zwart J.J. & Geerts C.C. (2016) Effect of planned place of birth on obstetric interventions and maternal outcomes among low-risk women: a cohort study in the Netherlands. BMC Pregnancy Childbirth, 16(1). DOI: 10.1186/s12884-016-1130-6  -Nove, A., Berrington, A. & Matthews, Z. (2012) Comparing the odds of postpartum haemorrhage in planned home birth against planned hospital birth: results of an observational study of over 500,000 maternities in the UK. BMC Pregnancy Childbirth, 12(130). DOI: https://doi.org/10.1186/1471-2393-12-130 Fler referenser hittar ni här: http://www.födahemma.se/forskning/  Och här även Svenska Barnmorskeförbundets Policydokument Hemförlossning (2020): https://www.barnmorskeforbundet.se/aktuellt/forbundet/policydokument-hemforlossning/ 

Mariko Hosozawa discusses the paper newly published in eClinicalMedicine, "Bullying victimisation in adolescence: prevalence and inequalities by gender, socioeconomic status and academic performance across 71 countries".Read the full article:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00422-3/fulltext

Dr Lauren Nephew, Assistant Professor of Medicine in the Division of Gastroenterology and Hepatology at Indiana University School of Medicine, joins Francesca Busuttil and Derek Anane, Senior Editors for eClinicalMedicine, to discuss her research focusing on disparities in liver transplantation, as well as racial and ethnic inequity in healthcare more broadly.

Rapha, João e Fred discutem sobre três aspectos da dengue: em quem pensar? Como diagnosticar? Como tratar? Esse episódio foi em parceria com o Whitebook! Acesse o aplicativo que te ajuda de forma rápida com informação de confiança na hora que você mais precisa! Clique no link para descobrir mais https://tinyurl.com/TdC-Whitebook e use o cupom CLINICAGEM para 30 dias grátis! Minutagem em breve. Referências: 1- Dengue - Diagnóstico e Manejo Clínico, adulto e criança. Ministério da Saúde. 2016. 2- JOUBERT, Antoine et al. Distinguishing non severe cases of dengue from COVID-19 in the context of co-epidemics: a cohort study in a SARS-CoV-2 testing center on Reunion island. PLoS neglected tropical diseases, v. 15, n. 4, p. e0008879, 2021. 3- ZENG, Zhilin et al. Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017. EClinicalMedicine, v. 32, p. 100712, 2021. 4- MASYENI, Sri et al. Serological cross-reaction and coinfection of dengue and COVID-19 in Asia: Experience from Indonesia. International Journal of Infectious Diseases, v. 102, p. 152-154, 2021. 5- Wilder-Smith, A., & Schwartz, E. (2005). Dengue in Travelers. New England Journal of Medicine, 353(9), 924–932. 6-NG, W. Y. et al. Atypical presentation of dengue infection among elderly: A retrospective cohort study. International Journal of Infectious Diseases, v. 101, p. 500, 2020. 7- ASHBURN, Percy Moreau; CARAIG, Charles F. Experimental investigations regarding the etiology of dengue fever. The Journal of infectious diseases, p. 440-475, 1907.

Коронавирусийн халдварын тархалтын улмаас сургууль хаасны дараа дахин нээхэд халдвар хэр зэрэг ихсэх вэ? Дэлгэрэнгүйг: Haapanen, M., Renko, M., Artama, M., & Kuitunen, I. (2021). The impact of the lockdown and the re-opening of schools and day cares on the epidemiology of SARS-CoV-2 and other respiratory infections in children–A nationwide register study in Finland. EClinicalMedicine, 34, 100807.

Já ouviu falar da Hipótese de Gaia? Teria o vírus da Covid-19 influência no controle da humanidade? Referências: “Bayer CEO Marijn Dekkers Explains: Nexavar cancer drug is ‘for Western pacients who can afford it'”. Knowledge Ecology International, 23 janeiro 2014. Disponível em: https://www.keionline.org/22401 ANDRIOLI, A. I. Transgênicos: as sementes do mal. São Paulo: Expressão Popular. 2012. 288p. SANTOS, B. S. O futuro começa agora – da pandemia à utopia. São Paulo: Boitempo. 2021. 426p   LI, H. et al. 2020. Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine, 28. Disponível em: https://reader.elsevier.com/reader/sd/pii/S2589537020303485?token=62D578F68F0084D6133A60C34BC546844A1512DC8CBFBF02930D1FB725C0F12CEB0F5070D6606303C488184AF2AEA3B2 BENDAYAN, M. et al. 2021. COVID‐19 in men: With or without virus in semen, spermatogenesis may be impaired. Andrologia, 53. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645883/ Estudo inédito no mundo realizado no InCor mostra que pacientes que tiveram Covid-19 podem sofrer disfunções cognitivas  Disponível em: http://www.incor.usp.br/sites/incor2013/docs/2021_Fevereiro_Estudo_Mental_Plus.pdf BIRON, D.G. et al. 2006. ‘Suicide' of crickets harbouring hairworms: a proteomics investigation. Insect Mol Biol. 2006;15: 731–742. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2583.2006.00671.x @ProfPadulla #ProfessorPadulla

This week, we review our medical group's experiences with using ECMO for refractory out-of-hospital cardiac arrests. Is this the future? References:Bartos JA, Frascone RJ, Conterato M, et al. The Minnesota mobile extracorporeal cardiopulmonary resuscitation consortium for treatment of out-of-hospital refractory ventricular fibrillation: program description, performance, and outcomes. EClinicalMedicine. 2020; 3 (26)Yannopoulos D, Bartos J, Raveendran G, et al.  Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST); a phase 2, single centre, open-label, randomized controlled trial. Lancet. 2020; 396 (10265): P1807-1816

We look back at a pre-COVID controversy in which nurses' unions fought against mandatory mask policies and won. Everyone seems to have forgotten about this, but obviously it is relevant to the situation today. Also, we talk about the growing body of evidence showing the lockdowns were ineffective.  Alex Berenson in Threadreader, Aug 7, 2020: "The Ontario arbitration fight about masks is really stunning..."CBC, Jan 8, 2014: Nurses gear up for fight over mandatory flu shots or masksCBC, Sep 10, 2015: Union says Ontario nurses can't be forced to wear masks in flu seasonCBC, Dec 4, 2019: B.C. nurses no longer need to get flu vaccine or wear masks, can rely on 'professional judgment'CanLII, Dec 16, 2015: Bloorview School Authority v Canadian Union of Public Employees, Local 4400CanLII, Nov 9,2016: William Osler Health System v Ontario Nurses' Association, 2016New York Post, Jun 6, 2020: WHO reverses position on face masks as coronavirus cases climbDonald L. Luskin in The Wall Street Journal, Sep 1, 2020: The Failed Experiment of Covid LockdownsDaily Mail, Jul 23, 2020: Lockdowns DON'T work, study claims: Researchers say stay-at-home orders made no difference to coronavirus deaths around the world - but prior health levels DIDLancet via EClinicalMedicine, Jul 21, 2020: A country level analysis measuring the impact of government actions, country preparedness and socioeconomic factors on COVID-19 mortality and related health outcomesIrish Times, Sep 2, 2020: German lockdown was too harsh says health ministerAssociated Press via USA Today, Sep 1, 2020: South Florida restaurants and casinos reopen as governor vows no more COVID-19 shutdownsCBC, Sep 9, 2020: Alberta won't 'micromanage' businesses as COVID-19 infections climb: KenneyJustice Centre News Release, Sep 9, 2020: Court ruling upholds Alberta bylaw that bans trailer signs on private landTheme Music "Carpay Diem" by Dave StevensSupport the show (https://www.jccf.ca/donate/)