Podcasts about evali

On this week's episode of Critical Care Time, we revisit ARDS... sort of! We are joined again by Dr. Whittney Warren & for the first time by Denitza Blagev for a dynamic discussion on ARDS imitators: Things that looks like ARDS but aren't technically ARDS - or are they? It's a bit of a confusing landscape as you'll see, where the lines are blurred and things get a bit murky. We'll unpack diagnoses like EVALI, DAH, AIP and more in the context of ARDS and help you guys come up with a framework for the "ARDS" patient who doesn't seem to respond to the tried and true approaches we discussed earlier this year on our ARDS Epic-sode!. As always, give it a listen and let us know what you think! Hosted on Acast. See acast.com/privacy for more information.

Send us a textDr. Okan Elidemir is the Chief of Pulmonology at Nemours Children's Health. In this episode, he shares cases of vaping injury, how addictive it is compared to regular smoking, and how to talk to your kids about consequences, peer pressure and managing stress.Guest: Dr. Okan Elidemir Nemours Pensacola https://tinyurl.com/yckx7cyw | https://www.medicalnewstoday.com/articles/vaping-vs-smoking | Info on Evali https://tinyurl.com/6jxhmjy5 Learn more about Escambia County School District: https://www.escambiaschools.org/Find additional links: https://www.voicesunitedineducation.com/podcast-episodesHost: Meredith Hackwith Edwards

Elektronik sigara kullanımına bağlı olarak ortaya çıkan bu akciğer hastalığı nedir? Sebepleri nelerdir?

The harms of smoking cigarettes are pretty clear. Smoking causes cancer as well as heart and lung diseases, and it's the leading cause of preventable death in the United States.When it comes to vaping, or electronic cigarettes, the risks are a bit more tricky to parse, especially if you read media reports about them. The outbreak of Vaping Use-Associated Lung Injury, also known as EVALI, in 2019 and 2020 made things even more confusing.The founders of Juul, the company that mainstreamed vaping in the early aughts, said they wanted to help people kick their smoking habits. But can vapes really help people quit? And how bad are they for you, really? And if you're addicted to vaping, what's the best way to stop?To answer those questions and more, Host Ira Flatow talks with one of the top researchers in the field, Dr. Jamie Hartmann-Boyce, assistant professor of health policy and management at the University of Massachusetts Amherst.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Drugi poudarki oddaje: - Računsko sodišče ptujskemu Komunalnemu podjetju za leto 2022 izdalo mnenje s pridržkom. - Na Celjskem vse več vlomov v avtomobile. Policija opozarja na samozaščitno ravnanje. - V Divači bodo kmalu zgradili sodobno optično omrežje. - Na Koroškem na mlade prenašajo znanje priprave značilnega rženega kruha.

Eden od razlogov za upadanje konkurenčnosti evropskega gospodarstva na globalnih trgih je tudi razdrobljen kapitalski trg, ki slabo podpira razvoj in rast novih prodornih podjetij. Evropska unija zato skuša povezati članice tudi na tem področju in vzpostaviti unijo kapitalskih trgov. Ker je slovenski trg šibak in povsem nerazvit, pri tem pričakuje upoštevanje posebnosti in podporo pri razvoju. Pot do tja je finančno ministrstvo nakazalo v strategiji razvoja kapitalskega trga, eden od konkretnih korakov pa je zakon o individualnih naložbenih računih. Izhodišča so pripravljena, predstavili so ji že strokovni javnosti, te dni jih pošiljajo v javno razpravo. Cilj je, da bi tak naložbeni račun imela velika večina prebivalcev. O ključnih rešitvah smo se pogovarjali z državno sekretarko na finančnem ministrstvu Nikolino Prah.

Drugi poudarki iz oddaje: - Kako v Postojni ozaveščajo o posledicah čezmernega nakupovanja poceni oblačil? -Potem ko so podaljšali delovni čas obratovanja lokalov v Portorožu, domačine razburja hrup -Na Štajerskem bo še več priložnosti za izobraževanje odraslih

Today, I continue the series on vaping that we started last week with my interview with Daniel Ament in episode #109. I hope you shared Daniel's episode with your teen (and maybe even gave his information to someone at your school so he could speak to all the students.)Vaping is ubiquitous in high school and more and more middle schoolers are taking up the habit every single day. Just because you've not seen evidence that your teen vapes or your teen has not admitted it to you, or they've promised you they'll never do it, does not mean that it isn't happening.This week I'm explaining how the serious risk of lung damage associated with vaping and e-cigarettes didn't end right before COVID when the CDC stopped tracking the EVALI (e-cigarette or vaping use-associated lung injury) epidemic. Simply put - COVID took the spot light off this other serious risk to public health. But in fact, there have been thousands upon thousands of cases in the US alone of vaping related lung injury or illness due to vaping, e-cigarettes or dabbing since then. As a matter of fact, there have been two additional double lung transplants for vaping related lung damage.I'll explain what's going on here and debunk some of the myths that vaping is "healthy" (that your teen may still be hanging onto.)Next week I'll be addressing how to help your teen resist starting vaping and how to help them stop.Show Notes and TranscriptFind our FREE Parenting Guides Here"I just wanted to let you know that I'm so thankful for your podcast! ...I'm so happy I discovered it!" Speaking of Teens Listener^If you feel the same way, please consider rating and reviewing my show! This helps people know the show is worth their time to listen. Tap here, to go to Apple podcasts, and scroll down until you see the STARS to tap on the last star, then tap on “Write a Review” and let me know what you love about the show. If you're listening in Spotify, you can also rate the show by going to the main episode page and tap the 3 dots to the right of the follow button, tap rate show and tap the 5th star!Thank you in advance for helping me help more parents!I drop new episodes every Tuesday and Friday so please tap Follow on the main episode page, so they'll be ready for you in your app. You can reach out to me with ideas for the show or guest suggestions here. Thanks so much for listening!Get the Parenting Cheat SheetCheck out PARENT CAMP - a monthly membership where you will learn how to strengthen your relationship and decrease the conflict with your teens and tweens (while improving their behavior.) Plus, expert advice on everything from drug use to screen time and everything in between. Join our Facebook Group for Free Support for Parents and others who care for Teens (and get immediate access to all the parenting guides above!) Connect with us on Facebook or Instagram

Marca 2024 bo začel veljati prenovljen način obračuna omrežnine, ki bo spodbujal k uporabi električnega omrežja v obdobjih, ko je obremenjenost manjša. V posameznem dnevu bodo vedno v uporabi zgolj trije časovni bloki. Kdaj bo elektrika najdražja oziroma najcenejša, je med drugim v Radijski tribuni pojasnila direktorica Agencije za energijo Duška Godina.

Gostja oddaje Obrazi sosednje ulice je naravovarstvenica iz Slovenske Bistrice gozdarka in naravovarstvenica Andreja Senegačnik, ki na mariborskem Zavodu za varstvo narave že 20 let bdi nad gozdovi in starimi drevesi na Štajerskem.

This month, Dr. Rachel Agbeko, Senior Editor of ADC, is joined by Dr. Jonathan Coutts (1), to discuss a viewpoint titled, "Toxic and addictive effects of nicotine on children and adolescents: are we sleepwalking into a public health disaster?" In their conversation they touch on reported statistics relating to adolescent vaping behaviour, EVALI syndrome, and the often-quoted "95% safer" rating of e-cigarettes versus standard cigarette consumption. Read the paper: https://adc.bmj.com/content/early/2022/08/09/archdischild-2022-323891 The ADC Spotlight podcast is the Archives of Disease in Childhood podcast covering areas that don't usually get much attention or might be taken for granted in children's health. This series is produced by Letícia Amorim and edited by Brian O'Toole. (1)  Neonatology Department, Royal Hospital for Children, Glasgow, UK Please listen to our regular podcasts and subscribe to Apple Podcasts, Google Podcasts, Stitcher, and Spotify to get episodes automatically downloaded to your phone and computer. And if you enjoy the podcast, please leave us a review at https://podcasts.apple.com/gb/podcast/adc-podcast/id333278832 

It's the greatest threat to confront vaping, and likely you may have missed it. Over the past 18 months, a dangerous misinformation campaign has emerged, falsely linking nicotine vapes to fentanyl. The media calls fentanyl-laced nicotine vapes an alarming trend that may be poisoning kids. A possibility that FDA Commissioner Robert Califf recently told Congress was likely only a matter of time. Joining us today to talk through the details of this threat is Tony Abboud, Executive Director of the Vapor Technology Association. Could this be another EVALI? Find out! Only on RegWatch by RegulatorWatch.com. Released: July 14, 2023 Produced by Brent Stafford https://youtu.be/r2lf6htOTfA Make RegWatch happen, go to support(dot)regulatorwatch(dot)com This episode is supported by DEMAND VAPE Make RegWatch happen, go to https://support.regulatorwatch.com   #RegWatch #VapeNews

Človeštvo se nahaja na razpotju. Časa za ukrepanja na področju podnebnih sprememb in vsesplošnega izčrpavanja naravnih virov je tako rekoč že zmanjkalo, obenem pa realni družbeni, ekonomski, politični in geostrateški dejavniki ter navzkrižni interesi ne ponujajo jasnega odgovora, kako se potrebnega civilizacijskega obrata sploh lotiti. V obsežnem delu Ekosistemska družbena ureditev se je analize preteklosti, sedanjosti in možnih poti v prihodnost, ki bi bila vzdržna tako za ljudi, kot tudi za vsa druga živa bitja na tem planetu lotil geograf zasl. prof. Filozofske fakultete Univerze v Ljubljani dr. Dušan Plut. V pogovoru je izpostavil nekaj ključnih poudarkov, celotna monografija je prosto dostopna na spodnjih povezavah.Ekosistemska družbena ureditev. Prvi zvezek: podstati in gradniki ekosistemske družbene ureditve Ekosistemska družbena ureditev. Drugi zvezek: Slovenija in Evropa

"Kljub drugačnemu prepričanju finance danes niso največji problem slovenskega zdravstva," pravi ekonomistka Petra Došenović Bonča. "Res pa žal ne živimo v nebesih." Neverjeten, a resničen, je podatek, da prebivalke in prebivalci Slovenije že zdaj direktno iz svojega žepa – tako rekoč iz svoje denarnice za zdravstvo vsako leto plačamo kar pol milijarde evrov. Tej vrtoglavi vsoti moramo prišteti še štiri milijarde in pol iz obveznega ter dopolnilnega zdravstvenega zavarovanja. To pomeni, da za delovanje zdravstvenega sistema, in to brez investicij, letno namenimo kar pet milijard evrov. »Kljub drugačnemu prepričanju finance trenutno niso največji problem slovenskega zdravstva,« pravi ekonomistka Petra Došenović Bonča, strokovnjakinja na področju ekonomike javnega sektorja in zdravstva. Izpostavlja nevarnost razrasta vzporednega, pogovorno rečemo kar zasebnega zdravstva, počasno uvajanje sprememb v javnem zdravstvu in tudi počasno definiranje košarice, ki jo zagotavlja obvezno zavarovanje. »Res pa žal ne živimo v nebesih,« dodaja. V tokratni Intelekti želimo osvetliti nekaj ekonomskih zakonitosti delovanja zdravstva. Z nami bodo prof. dr. Petra Došenović Bonča (Ekonomska fakulteta v Ljubljani) in novinar Matej Zwitter (Center za preiskovalno novinarstvo Oštro). Svojo izkušnjo z nizozemskim sistemom bo opisala Tina Batistuta, o avstrijskem zdravstvu bo poročal zdravnik Gorazd Kovač, o ameriškem pa naš dopisnik Andrej Stopar. K sodelovanju jih je povabil Iztok Konc. Foto: BoBo

Last night on @Timcast @TaylerUSA argued that #vaping is worse than smoking. Hear CDC, FDA, and Bloomberg lies, including fake lung disease #EVALI in these 6.5mins. It was a pile-on. Includes: @IanCrossland @Lukewearechange. Thanks @philthatremains for your common sense. Only on RegWatch by Regulatorwatch.com. Released: January 11, 2022 Produced by Brent Stafford https://regwat.ch/3kcp2yA This episode is supported by DEMAND VAPE Make RegWatch happen, go to https://support.regulatorwatch.com #RegWatch #VapeNews

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.12.520128v1?rss=1 Authors: Manna, V., Caradonna, S., Dwyer, S., Pizutelli, V. Abstract: Vape-pens or electronic cigarettes (e-cigarettes) are handheld battery powered devices that use a vape-liquid to produce a vapor that is inhaled by the user. The active ingredients in commercial vape-liquids are commonly nicotine, tetrahydrocannabinol or cannabidiol. A consequence of the rise in e-cigarette usage was the 2019 emergence of a vaping-induced respiratory disease denoted "e-cigarette or vaping use-associated lung injury" (EVALI). One of the suspected causes of EVALI is Vitamin E Acetate (VEA), which was found to be a diluent in certain illicit tetrahydrocannabinol vape-pens, whereas nicotine is commonly diluted in equal parts propylene glycol and vegetable glycerin (PG:VG). The prevalent use of e-cigarettes by both adult and young adult populations and the emergence of a novel illness has made understanding how e-cigarette vapors affect our respiratory tissues a public health concern. We have designed and produced a simple device that can operate commercial e-cigarettes and deliver the vapor to a chamber containing a standard cell culture multi-well plate. Here we utilize our device to investigate how human airway mucociliary tissue cultures respond after chronic exposure to vapors produced from either PG:VG or VEA. We note several differences between how PG:VG and VEA vapors interact with and alter airway tissue cultures and suggest potential mechanisms for how VEA-vapors can exacerbate EVALI symptoms. Our device combined with primary human airway tissue cultures make an economical and compact model system that allows for animal-free investigations into the acute and chronic consequences of e-cigarette vapors on primary respiratory cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Evropska unija se je v Strategiji ''od vil do vilic'' zavezala, da bo do leta 2030 za polovico zmanjšala porabo fitofarmacevtskih sredstev. Zakonodajni predlog, po katerem naj bi na zaščitenih območjih, kot je Natura 2000, povsem prepovedali njihovo uporabo, je v Sloveniji doživel silovit odpor. Kmetje so ga označili za okoljsko norost, saj takšna območja pokrivajo polovico slovenskega ozemlja. Tudi kmetijsko ministrstvo se je postavilo na stran tistih članic Unije, ki zahtevajo prožnost oziroma omilitev ostrih zahtev, češ da bo sicer ogrožena prehranska varnost. Kaj so Sloveniji prinesla dozdajšnja pogajanja? Kako bomo opuščali in s čim nadomeščali pesticide ter hkrati pridelali dovolj hrane? O tem voditeljica Jernejka Drolec z gosti. Gostje: dr. Jernej Drofenik, namestnik direktorja Uprave Republike Slovenije za varno hrano, veterinarstvo in varstvo rastlin pri Ministrstvu za kmetijstvo, gozdarstvo in prehrano;Jernej Redek, konvencionalni kmet, strokovni tajnik Sindikata kmetov Slovenije;Zvone Černelič, ekološki in biodinamični kmet, predsednik Društva za biološko-dinamično gospodarjenje Ajda Posavje;Primož Žigon, koordinator za integrirano varstvo rastlin na Kmetijskem inštitutu Slovenije; dr. Urška Blaznik z Nacionalnega inštituta za javno zdravje.

Recorded Live on 12/3/22 This Week's Blog: https://casaa.org/casaa-interviewed-about-vaping-bans-and-more-tobacco-harm-reduction-news/ YouTube Live Replay: https://youtu.be/2WYE2_pow7s Facebook Live Replay: https://fb.watch/hbCN6bi6bU/ Twitter Live Replay: https://twitter.com/CASAAmedia/status/1599153337483821058?s=20&t=pSJWF9JBDI2N4P8umKn86Q Join CASAA: casaa.org/get-involved/join/​ CASAA State Pages: casaa.org/get-involved/state-...​ Donate: casaa.org/get-involved/donate/​ Shop: casaa.threadless.com/collections​ Music: Fight On Your Side by Crowander freemusicarchive.org/music/cr...

The War on Vaping continues unabated, as the U.S. Centers for Disease Control states in a group call with anti-vaping lobbyists that the teen vaping “epidemic” is NOT over. And the FDA digs in, refusing to set the record straight with the American public over the perceived risks and harms of vaping.  Regulators and government have created a “chaotic hot mess” in the U.S., says Clive Bates, tobacco control policy expert and former Director of Action on Smoking and Health (UK), in today's episode of RegWatch. Hear Bates break down the 2022 NYTS youth vaping stats, his call for the CDC to stop its dishonest spin of youth vaping data, and his assessment of the FDA's failed “authorization regime.” Only on RegWatch by RegulatorWatch.com Released: October 20, 2022 Produced by Brent Stafford This episode is supported by DEMAND VAPE https://youtu.be/vCBtjCMS-xA Make RegWatch happen, go to https://support.regulatorwatch.com

The research flow of “exaggerated” and “distorted” information about safer nicotine products is “not going to end any time soon,” says Dr. Brad Rodu, professor of medicine from the University of Louisville. Rodu has made a career battling forces responsible for pushing suspect science in the field of tobacco control. In this episode of RegWatch, he takes the CDC to task over EVALI and its teen vaping and smoking-related deaths data. Is there truth behind the CDC's numbers? Find out! Only on RegWatch by RegulatorWatch.com *Shot on location at the Global Forum on Nicotine in Warsaw, Poland Released: July 22, 2022 Produced by Brent Stafford https://youtu.be/v2tXjjaEIlM This episode is supported by DEMAND VAPE Make RegWatch happen go to https://support.regulatorwatch.com  

Michelle and Nikki started Elavi to fulfil their own need for  Functional, shelf-stable snacks designed to go with you anywhere and help with cognitive focus, balanced mood, athletic recovery, and overall vitality in a delicious, convenient way. 4:00 Starting by bootstrapping, which is amazingly hard to 5:20 Balancing full time focus form one co-founder without both having to deplete their safety nets and the importance of having a co-founder. Making contribution of both sweat equity and capital equity and managing the dynamics. 9:30 Starting their retail strategy local to keep acquisition costs down, and find out what their sales and follow up strategy looks like. 12:00 What types of sales collateral do you need? What unexpected customers did you get. 15:00 Working with distributors to work into big box retail 18:00 Hard lessons learned including shipping LTL truck loads to residential SF addresses, and working with retailers. 20:00 Discussing DTC or retail sales strategy and creative marketing strategies to connect with customers. Sign up for Chris' weekly newsletter https://chrismeade.beehiiv.com/subscribe (Cross Commerce) here, and connect with him on https://twitter.com/chrismeadej (Twitter) and https://www.linkedin.com/in/cjmeade/ (Linkedin). Chris Meade is the co-founder & CMO of CROSSNET, the world's first four-way volleyball game. Chris was honored with Forbes 30U30 for the 2021 Sports category. CROSSNET combines elements of the childhood game four square and volleyball in a competitive game to 11, win by 2. CROSSNET is now available at 3000+ retail stores such as Walmart, Target, DICKS, Academy Sports, Sam's Club and 20+ other retailers.

In this episode of Cracking Addiction we are again joined by Dr Colin Mendelsohn to discuss the controversies around vaping including the risks around vaping, the thoughts of vaping being a gateway to smoking cigarettes, the risks of EVALI, the role of 'Big Tobacco' in vaping, looking at the evidence around vaping and challenging some of the latest reviews around vaping Latest Blogs https://www.meducate.com.au/blog About Meducate ® Meducate provides online education for doctors, clinicians, health professionals and the public. See the website to browse the many different talks and courses available https://www.meducate.com.au

Cene nepremičnin so vrtoglave. K temu najbrž prispevajo še vedno nizke obrestne mere, temu pa je dodatno prilila olja na ogenj sprostitev omejitev za najem stanovanjskih posojil, ki jih je objavila Banka Slovenije. Pozanimali smo se, zakaj se je Banka Slovenije odločila za ta korak.

Episode 88: EVALI. Nugdeep and Jeffrey present E-cigarette and Vaping Associated Lung Injury (EVALI), including symptoms, diagnosis, and treatment. Introduction includes a word of advice for matching and not matching students in 2022.  Introduction: The Match 2022 is over.  By Hector Arreaza, MD. Read by Valeri Civelli, MD. Another Match season is behind us. It's time to celebrate and prepare for a new stage of your career. As an interesting fact, the American Association of Family Physicians announced that in 2022 the highest number of family medicine residents matched.Positions for family medicine residencies have been steadily growing for the last 13 years in a row. There are 756 family medicine categorical and combined residency programs, that's 15 more programs than in 2021. Also, in 2022, osteopathic medical schools had the historic highest number of students matching into family medicine, to be exact 1,496 DO seniors matched to family medicine this year, that's 58 more students than 2021.During this season, the number of U.S. medical grads matching into family medicine “did not increase despite a larger number of positions available.”[1]If you did not match this year, the Match can also be a time of reflection and goal setting as you prepare with optimism for the next season. To increase your chances to match next year, Dr. Margarita Loeza advised in an AMA article[2] to stay in touch with your medical school, find a job in a clinical setting, take Step 3, and try a new approach during next season. For example, you may consider applying to a higher number of programs or even more than one specialty. Residency training is the primary way to get licensed to see patients, but there are hundreds of alternative ways to pursue your passion for medicine. Do not give up on your goals. “Never give up on something that you can't go a day without thinking about.” ―Winston Churchill.This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it's sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. Page BreakEVALI.By Nugdeep Singh, MS4; and Jeffrey Nguyen, MS4. Ross University School of Medicine. Participated in the discussion: Hector Arreaza, MD. N: Good afternoon listeners. My name is Nugdeep Singh, and I am a fourth-year medical student. J: Hello, and I'm Jeffrey Nguyen, also a fourth-year medical student. Thank you for having us today Dr. Arreaza. N: Today we will be talking about E-cigarette and vape-associated lung injury (EVALI), also known as vaping-associated pulmonary injury (VAPI). But, before we get into the medical pathology of E-cigarettes and vapes, why don't we give a little background on them.Arreaza: EVALI and VAPI sound like another Indian holiday or an Italian dessert, but EVALI and VAPI are certainly no joke. J: Sure, let's get started. So, E-cigarettes are battery-operated devices that heat liquids containing nicotine to produce an aerosol that the user inhales. Long-term health effects and whether they help an individual quit smoking has been controversial, as there has not been much research on it. These E-cigarettes have raised public health concerns on smoking prevalence and their potential use by children. In 2019, over 5 million children and adolescents were using 3-cigarettes. This represented an increase in e-cigarette use by high school students from 12% in 2017 to 28% in 2019. In fact, Massachusetts legislation bans the sale of all flavored tobacco products starting in June 2020. Nicotine is the main ingredient in the liquid, however, there are other constituents that are carcinogenic potential. Nugdeep, can you go over some of these ingredients? N: Yea, let's start with nicotine. The level of nicotine varies between 0 to 36mg/mL, though it can be higher in some. Nicotine salt is another variant that can provide a different sensation in a user's throat. Next is propylene glycol, which are humectants, and they are the main component of most E-cigarette liquids. Arreaza: When you mentioned proPYlene glycol, I immediately thought of “PEG”. PolyEthylene Glycol, does it ring a bell? Yes, it's a common laxative, but besides that it's used in the mRNA COVID-19 vaccines. Having allergy to PEG is one of the few contraindications of the COVID-19 vaccine. But you are not talking about PEG, you are talking about propylene glycol, which is a lightly sweet substance used in e-cigarettes, which can cause chemical conjunctivitis or respiratory irritation.  The consequences of chronic inhalation of propylene glycol are still unknown.N: Finally, there are flavorings and there are about 7000 flavors available. Some examples include candy, fruits, sodas, and alcohol flavors. J: Can I add something real quick? N: Yea, of course. J: Although these flavorings do add taste to the experience, it attracts E-cigarettes in the youths, especially those who do not already smoke. So, kids, don't start smoking these just because of the different flavors. Sorry for interrupting you, you can continue. N: It's all good. To continue where I left off, metals such as tin, lead, nickel, chromium, and arsenic have also been found in these liquids. In addition to these, people can also use aerosolized THC or cannabinoid oils with these E-cigarettes. J: Wow, there are so many ingredients found in these liquids that the public is not aware of. Now that we know a little more about E-cigarettes, let's talk about how they affect the lungs. N: Yea, let's get to it. E-cigarette and Vape Associated Lung Injury was first recognized in the summer of 2019 and to date, there are more than 2800 cases that have been reported to CDC as of February 2020. Among those, 68 deaths have been recorded.  Approximately 66% are male users and nearly 80% are under the age of 35. Unfortunately, 22% of the patients have underlying asthma. J: Currently, we still don't fully understand how E-cigarettes affect the lungs. Reported cases have hypothesized that lung diseases are associated with acute eosinophilic pneumonia, diffuse alveolar hemorrhage, acute and subacute hypersensitivity pneumonitis, respiratory bronchiolitis-associated pneumonitis, and interstitial lung disease, suggesting that more than one mechanism of injury may be involved. It is important to understand that there is no evidence of an infectious etiology. N: One interesting fact is that when they took fluid samples from the lungs (called bronchoalveolar lavage) from patients with lung injury from E-cigarettes, they noticed that the sample contained THC and/or Vitamin E acetate. Of course, other additives were included, however, these two were in the majority of fluid samples. In fact, the product Juul® was recently found to have a strong association with EVALI. Arreaza: JUUL was a commercial success, compared to Uber and Airbnb, but it has been involved in a lot of controversies around the world. J: Vitamin E acetate? But isn't that found in many other products that we use on a daily basis? N: Definitely, Vitamin E is found in many foods including vegetable oils, cereals, meats, fruits, and vegetables. It is also available as dietary supplements and is in cosmetic products such as skin creams. There are no known harms when Vitamin E acetate is ingested or applied to the skin, however, research suggests that it interferes with normal lung functions. J: Interesting, who knew something as simple as Vitamin E can cause harm to the lungs when used differently. To continue, let's talk about symptoms that patients present with. Respiratory symptoms include shortness of breath, cough, chest pain, pleuritic chest pain, and hemoptysis. Patients may have subjective fever and chills. GI symptoms include abdominal pain, nausea, vomiting, and diarrhea. Vital signs can be remarkable for tachycardia, tachypnea, and hypoxemia that may progress to respiratory failure. Nugdeep, are there any criteria to meet the diagnosis of E-cigarette and Vape Associated Lung Injury? N: Before I talk about how to make the diagnosis, I want to mention that CDC recommends obtaining detailed information on the type of vaping device used, type of substance used, frequency of vaping, and where these devices were obtained. To answer your question, in order to make the diagnosis, you need:Use of e-cigarettes in the past 90 days.Chest x-ray or CT chest showing lung opacities without any signs of lung infection.Negative influenza PCR, respiratory viral panel, and other respiratory infections like urine antigen test for legionella. (COMMENT: COVID-19?) Once the diagnosis has been made, what are the treatment options? J: Since this is a new and upcoming problem, there are no known treatments to date. The most important thing is to rule out infectious processes, such as community-acquired pneumonia. However, patients diagnosed with EVALI can be started on antibiotics empirically to cover pathogens of community-acquired pneumonia. Systemic glucocorticoids have been used; however, the efficacy has not been formally studied. The decision to initiate systemic glucocorticoids is challenging due to various presentations, but it has been suggested to initiate systemic glucocorticoids for patients who meet the criteria for EVALI and have progressively worsening symptoms and hypoxemia. So, what does supportive care entail?N: 95% of patients with this diagnosis will require hospitalization for supportive care, such as supplemental oxygen with a target pulse oxygen saturation of 88-92%. If hypoxemia worsens, management follows that for acute respiratory distress syndrome. In order to discharge a patient, it is important to ensure vital signs, oxygen saturation and exercise tolerance are stable for 24-48 hours prior to discharge. Jeffrey, to conclude this podcast, can you talk about the prognosis of EVALI? J: Sure. When comparing fatal vs nonfatal cases of EVALI, the proportion of fatal cases was higher among patients over the age of 35 and those with a history of asthma, cardiac or mental health conditions. Case reports among adolescents suggest residual lung dysfunction, like short-term diffusion abnormalities. However, it remains unclear whether abnormalities persist in the long term. We would need to wait while they do more research about this condition. Arreaza: E-cigarette use is increasing, and we need to be aware of the signs and symptoms of E-cigarette and vape-associated lung injury (EVALI) to start treatment appropriately. Remember to include e-cigarettes and vaping when you ask questions about smoking. ____________________________Now we conclude our episode number 87 “EVALI.” EVALI stands for E-cigarette and vape-associated lung injury. The medical community has been increasingly concerned about the safety and health consequences of e-cigarettes and vaping. When you encounter a patient with respiratory complaints, remember to ask about any form of tobacco use, including e-cigarettes and vaping. If you suspect a patient has EVALI, confirm the diagnosis with a chest x-ray or CT scan and rule out any infectious etiology. Consider hospital admission if symptoms are severe, for example, if the patient has shortness of breath or requires oxygen. Even without trying, every night you go to bed being a little wiser.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email at RioBravoqWeek@clinicasierravista.org. This podcast was created for educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Valerie Civelli, Nugdeep Singh, and Jeffrey Nguyen. Audio edition: Suraj Amrutia. See you next week! _____________________References:Mitchell, David, Family Medicine Welcomes Largest Class of Residents Ever, American Association of Family Physicians, aafp.org, March 18, 2022, https://www.aafp.org/news/education-professional-development/2022-match-day.html. Smith, Timothy M., What if you don't match? 3 things you should do, American Medical Association (ama-assn.org), https://www.ama-assn.org/residents-students/match/what-if-you-don-t-match-3-things-you-should-do. Kaplan, Sheila, Andrew Jacobs, and Choe Sang-Hun, The World Pushes Back Against E-Cigarettes and Juul, The New York Times, nytimes.com, March 30, 2020 https://www.nytimes.com/2020/03/30/health/vaping-juul-international.html.

Journalist and RegWatch host Brent Stafford joins Shaping Vaping to discuss Congress' last-minute synthetic nicotine rider, CDC's misinformation campaign on EVALI, and the motivations behind the anti-vaping movement. Plus, this week's Media Lap Dogs.

Journalist and RegWatch host Brent Stafford joins Shaping Vaping to discuss Congress' last-minute synthetic nicotine rider, CDC's misinformation campaign on EVALI, and the motivations behind the anti-vaping movement. Plus, this week's Media Lap Dogs.

Student panel discussion on the subject of VAPING. This may sound cliché, but "it isn't cool." We sat down and discussed with students the ill effects of vaping.  In February 2020, the CDC CONFIRMED 2,807 cases of e-cig/vaping use associated lung injury (EVALI) and 68 deaths.  Research suggests vaping is bad for both your heart and lungs. 

Sure...you ask your patients if they vape, but how much do you know about the world of vaping? Are they using a cigalike, a vape pen, or a JUUL? And are they using standard cartridges or have they bought a custom vape juice? What types of vape juice are most associated with EVALI? In this episode we review vaping - the history of the industry, the health effects, and the societal trends.

Nos cuenta sobre la Ley General del Tabaco y la enfermedad EVALI

Hinko Smrekar je bil mojster družbeno-politične satire in karikature, vsestranski likovnik, ki je ustvarjal po naročilu za publikacije ? časopise in knjige. Ustvarjal je predvsem risbe s tušem, občasno dodal akvarel, pastel ali gvaš, pa grafike. Ustvarjal pa je tudi nekaj kipov in oljnih slik. Nekatere zgodbe težko razvozlamo, ker tudi časopisov ni. V Narodni galeriji drugi del razstave o Hinku Smrekarju predstavlja obdobje po prvi svetovni vojni do njegove usmrtitve leta 1942. Do 13. februarja 2022 je na razstavi Hinko Smrekar, II. del na ogled skupaj približno 200 orginalnih del, tudi nekaj kipov.

A COP9 keltette ostoba hullámok fölé emeljük periszkópunk, miközben elmeséljük ennek a konferenciának az elképesztő történetét. Charlie hangja csilingel, Fifika a telefonját babrálja, Mujo pedig csak fest, csak fest... miközben mindenkinek kisimul a szakálla. Show notes Olvasói komment

The jury's still out on the newest cannabinoid to take the world by storm -- Delta-8 THC. Is it safe, legal, or an interesting high? On this episode two wise men with competing points of view weigh in.Does this sound familiar?This episode is brought to you by Medical Cannabis Mentor, providing state-of-the-art education to dispensary personnel, healthcare providers and patients. A new cannabis product hits the shelves and suddenly mainstream media is reporting a surge in illnesses and hospitalizations. It happened on June 29 when University of Virginia Hospital reported dozens of people crowding the ER after ingesting…guess what…the cannabis industry's newest rock star product, D8 THC!I don't want to be an alarmist but I immediately wondered if the introduction of D8, which very few people really understand, is going to be this year's version of EVALI, the scary vape-related lung diseases that killed 68 people and sickened 3,000 more in 2019 and 2020? Or is this clickbait about another cannabis product that hit the market fast, created through-the-roof consumer demand, and has yet to be federally regulated?I'm not sure yet, but it's safe to say that Delta-8 THC (D8) presents a great opportunity and a great challenge to the cannabis industry: Big financial upside and some POTENTIALLY serious downsides. To get a clearer perspective on this “new” cannabinoid (that was in fact identified in 1941 by scientist Roger Adams) I invited two wise people with competing interests to discuss.Dr. Matt Elmes holds a Ph.D. in Molecular and Cellular Biology from Stony Brook University, where he focused on endocannabinoid and phytocannabinoid cellular transport mechanisms. Today Matt is Scientific Director for CannaCraft, one of the largest cannabis product manufacturers in the world. Chris Fontes is CEO and Founder of Project Hemp Flower, a website where farmers sell their smokable flower directly to consumers. Fontes and his team hunt and curate high-grade product that provides consumer confidence because of their quality control. His latest brainchild is Trojan Horse Edibles, full-spectrum, full-strength dispensary grade edibles from hemp CBD.Listen in to learn if D8 is natural or unnatural… safe or harmful…and how its high differs from that of good old Delta-9 THC. And get ready for D10, which according to my sources, will soon be hurtling down the pike!Is it possible that THC has more variants than COVID????See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

For most teenagers, social media use has become an integrated part of their lives. According to recent research, 85% of teens have at least one active social media profile and almost half of teens are online “almost constantly”. Given that our patients are increasingly spending their time online, how do we leverage social media to help improve their health outcomes? This episode features Dr. Rose Marie Leslie, the “Tik Tok Doc”, who went viral in 2019 with her health education videos about vaping and EVALI. With close to 1 million followers, many of whom are teenagers, listen as Dr. Leslie talks to us about how to use social media for health education and what things clinicians should consider before venturing online to inform and interact with their patients.

Prior to the COVID-19 (SARS-CoV2) pandemic, vaping-related illness was the prevailing public health concern. The incidence of vaping related illnesses mainly e-cigarette, or vaping, product use–associated lung injury (EVALI) declined with the arrival of COVID 19 but EVALI should still be considered as a differential diagnosis for people with COVID-19 for reasons outlined in this review.  This narrative review describes vaping devices, summarizes the adverse health effects of vaping on the lungs and other systems, considers the potential interplay between vaping and COVID-19, and highlights gaps in knowledge about vaping that warrant further research.

The WHO knows that they are pushing smokers to keep on smoking and they really don't care.This week they released their Report in the Global Tobacco Epidemic 2021 with a one hour propaganda video, a full out assault on social media and with the help of Mikey Bloomberg they plan a two week assault on #vaping.We'll dissect the video and have comments, they won't be kind.https://www.youtube.com/watch?v=vpc2q...Gizmodo is reporting that a woman previously diagnosed with Covid-19 was really suffering from EVALI.https://gizmodo.com/woman-hospitalize...The Journal of Pediatrics says that kids and parents have a huge impact on whether kids #vape or not. Apparently kids can make decisions and if they have good parents they make good decisions.https://pediatrics.aappublications.or...The Journal of Addiction says that the increase of kids vaping appears to not negatively impact the population burden of nicotine dependence and that it is probably due to the #safernicotine delivery method.https://onlinelibrary.wiley.com/doi/1...Senator Mitt Romney wants vaping companies to pay FDA Tobacco User Fees, and is introducing bicameral legislation to make that a reality.https://twitter.com/SenatorRomney/sta...All that and Irish Potatoes.Join us Friday Night at 10pm Eastern on Facebook, YouTube and Twitter for #sonoflibertyradio.

The patch, the gum, lozenges, medication — it seems like there are endless ways to quit smoking. But for some people, none of them work, and they have to head off the beaten path to find something that’ll help them quit. On this episode, we take a look at some of the less-studied ways people have used to quit smoking, why they work — or don’t — and what can get in the way. We hear stories about Allen Carr, the man behind “The Easy Way to Stop Smoking,” and his quest to gain acceptance from the scientific mainstream; American Indians’ deep cultural connection to tobacco, and how it’s been exploited; and the truth behind the effects of vaping on our health, and what that means for ex-smokers. Also heard on this week’s episode: Vaping has been marketed as a revolutionary tool to help smokers quit — but are e-cigarettes actually healthier than regular ones? Reporter Liz Tung looks into what we know about the risks of vaping, what caused EVALI, the mysterious lung-related illness that’s been linked to e-cigarettes, and how all of the above is affecting smokers who’ve decided they’re ready to quit.

Hét végén közös programunk volt, Mujo elgondolkozott a költözésen, fifika pedig az ereinek felvágásán. Folyamatosan félre vagyunk vezetve a rengeteg túlgondolkozó által, bennünk pedig egyre jobban erősödik az érzés, hogy el kell zárni a pénzcsapot. FONTOS!Közeleg a World Vape Day, ha szeretnétek ti is egyenképet megosztani a közösségi médiában, küldjetek nekünk egy fotót az e-mail címre, egy rövid mondatot amit szeretnétek a képen látni, és a keresztneveteket mondjuk. Mi megszerkesztjük a fotód, és visszaküldjük emailben. Show notes

A hot topic of conversation at the school board meeting this last week was the rise in popularity of Juul smoking cartridges.  Juul smoking is a growing problem among young people nationwide to include the small schools and communities such as Wishek and Ashley. Juul smoking is when a cartridge (or pod) is filled with liquid. “The liquid typically contains nicotine, flavorings, and other chemicals. When you puff on the mouthpiece of the device, it activates a heating element. This heats up the liquid in the pod and turns it into vapor.” -familydoctor.org One Juul pod (cartridge) can last for 200 puffs and contains about 0.7ml of liquid. This liquid or nicotine in an entire pod is equal to a pack of 20 cigarettes, and 10 puffs equal 1 cigarette. As the number of puffs depends on the person, so does the level of nicotine. However, a large minority of individuals take more than 140 puffs per day. For teachers and teens, this poses a problem. When talking with Principal Christopher Doane of the Ashley School, his main concern was the teens’ health. “Whether those health issues come now or down the road, I honestly don’t think the kids realize the risks.” Doane compared it to “20 years ago when cigarettes were a trend and cool to do. Kid’s think Juul smoking is mostly vaping water, and it isn’t, which they will find out later on when certain health conditions arise as they did from cigarettes. At present, however, there aren’t enough studies done to make those conditions well known.”  However, some studies and health concerns that have been done include the following: You have a chronic cough. Chemicals in vapes could irritate your throat. ... You have chest pain or shortness of breath. Fluid could collect in your lungs and make breathing difficult or even impossible. ... You vomit, feel nauseous, or have diarrhea. ... You’re running a fever. ... You feel tired. A person is considered to be vaping too much if they show any of these signs. -insider.com Is vaping less harmful than smoking? Although Juul smoking or vaping is less harmful than smoking, it is still not considered safe. Michael Blaha, M.D., M.P.H., director of clinical research at the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, explains, “E-cigarettes heat nicotine (extracted from tobacco), flavorings and other chemicals to create an aerosol that you inhale. Regular tobacco cigarettes contain 7,000 chemicals, many of which are toxic.  While we don’t know exactly what chemicals are in e-cigarettes, Blaha says, “there’s almost no doubt that they expose you to fewer toxic chemicals than traditional cigarettes.” However, there has also been an outbreak of lung injuries and deaths associated with vaping. As of Jan. 21, 2020, the Centers for Disease Control and Prevention (CDC) confirmed 60 deaths in patients with e-cigarette, or vaping, product use associated lung injury (EVALI).” Other health concerns in students and vaping include decreased oxygen supply to the brain each time a student vapes, which can negatively affect brain development, decrease concentration levels, and clear learning.  As vaping contains nicotine, it can also be detected in a student’s urine, blood, saliva, hair, and nails, showing how absorbent a person’s body reacts and the proven harmful effects on the lungs and cardiovascular health.  These are major health concerns in which students seem to be unaware. According to certain teachers’ reports and the Truth Initiative research, and local Principals and teachers to include Principal Doane from Ashley and Superintendent Shawn Kuntz from Wishek, some of their students had no idea what they were vaping was nicotine or contained harmful chemicals. In fact, “nearly two-thirds of JUUL users aged 15-21 were not aware the product always contains nicotine.” As health is the main concern, it is not the only concern. How the youth vaping epidemic is impacting teachers and...

After pediatric pulmonologists at Children’s Health saw a spike in adolescent patients referred with unusual symptoms that resembled pneumonia and viral gastroenteritis, they set out to learn why.

¿Qué hay dentro de tu vape, vapeador o cigarro electrónico? Los extractos de cannabis, incluidos los vapeadores desechables, se legalizaron en Canadá en octubre de 2019. Casi al mismo tiempo, se estaba desarrollando un brote de enfermedad pulmonar grave relacionada con el vapeo en los EE. UU. El brote de EVALI por sus siglas en Inglés (un acrónimo que se refiere a una lesión pulmonar asociada al uso de productos de cigarrillos electrónicos o vapeo) ilustró la necesidad de productos probados y regulados. En EE.UU., donde el cannabis sigue siendo ilegal a nivel federal, ha habido 68 muertes y más de 2.800 hospitalizaciones, en los 50 estados, debido a enfermedades o lesiones relacionadas con el vapeo, y la mayoría de los casos están vinculados a vapores ilícitos de cannabis. Hasta agosto de 2020, se habían reportado 20 casos de enfermedades pulmonares asociadas con el vapeo a la Agencia de Salud Pública de Canadá, incluidos cinco casos relacionados con el vapeo con tetrahidrocannabinol (THC) solamente, y tres relacionados con nicotina, THC y otras sustancias. No está claro dónde se compraron los vaporizadores. Regulado por la Ley del Cannabis, los vapores de cannabis no pueden contener nada más que sustancias portadoras o el vehículo, agentes aromatizantes y sustancias que sean necesarias para mantener la calidad o estabilidad del producto. Están prohibidos la nicotina, la cafeína y el alcohol etílico, al igual que los colorantes, azúcares, edulcorantes, nutrientes, minerales y vitaminas, incluido el acetato de vitamina E, un ingrediente fuertemente implicado en el brote de EVALI de acuerdo al Centro para el Control y la Prevención de Enfermedades (CDC) de los Estados Unidos. Se ha encontrado acetato de vitamina E en muestras de líquido pulmonar de pacientes y en muestras de productos analizados por la Administración de Drogas y Alimentos de EE. UU. "La crisis de EVALI de 2019 fue una verdadera revelación porque demostró que no podemos asumir que lo que hay en estos líquidos electrónicos es inherentemente seguro", dijo a The GrowthOp el Dr. Mark Ware, director médico de Canopy Growth. Los ojos han estado puestos en un componente llamado phytol, un terpeno que se encuentra naturalmente en el cannabis en pequeñas cantidades. El estudio, que se realizó en ratas, encontró que no había un rango de exposición seguro para el fitol cuando se usaba como excipiente en un producto de vapeo. El estudio comparó la toxicidad potencial del fitol y el propilenglicol, que se usa comúnmente como agente diluyente en la industria de los cigarrillos electrónicos. Las ratas fueron expuestas a fitol o propilenglicol durante hasta seis horas al día, durante 14 días. Después de sólo uno o dos días, las ratas mostraron signos clínicos graves, que incluían pérdida de peso corporal, daño al tejido respiratorio y mortalidad. “Muy rápidamente, quedó claro que el fitol inhalado causó un daño significativo a los animales que participaron en la investigación. Y de hecho, terminamos el estudio antes de tiempo debido a eso", dijo el Dr. Ware. En una declaración a The GrowthOp, un portavoz de Health Canada dijo que se pidió a los titulares de licencias de venta de cannabis a que identificaran los datos, estudios o reacciones adversas disponibles relacionados con la seguridad del fitol en los productos de cannabis inhalables. “Con base en las respuestas recibidas, Health Canadá determinó que había una pequeña cantidad de productos en el mercado legal que contenían fitol agregado y que la mayoría tenían niveles bajos de concentración de menos del dos por ciento”, dijo el portavoz. "Health Canada no tiene conocimiento de ninguna evidencia directa de que los niveles bajos de concentración de fitol en los productos de vapeo de cannabis que están disponibles en el mercado legal puedan causar daños a la salud del usuario cuando se usan según lo previsto", dijo el portavoz. Y aunque las empresas deben conservar registros de los ingredientes contenidos en sus vapeadores, y los ingredientes son visibles en la etiqueta del producto, los consumidores exigen un desglose más detallado de los productos de vapeo, incluidas las concentraciones de terpenos. Por otra parte, el Dr. Ware dice que no preocupan los niveles de terpenos a los que las personas están expuestas en los vaporizadores de flores secas, pero agrega: “Realmente sentimos que cuando hay niveles de terpenos más altos que los que se encuentran en la flor, en los cigarrillos electrónicos-vapes- tenemos que empezar a tener mucho cuidado. Hay muchas cosas que desconocemos sobre la inhalación de terpenos en el pulmón humano, se desconocen sus efectos a largo plazo ". La regulación de los vaporizadores es una historia en curso.

Kamu berusaha buat berhenti ngerokok, semua cara udah kamu coba, Terus kamu denger dari temen temen kamu, ada alternatif yang lebih aman namanya Vape, terus karena katanya-katanya si A dan si B yang notabenenya bukan dokter, kamu percaya aja bahwa nge-Vape aman. wah kamu harus simak topik yang diomongin sama yudhis dan ayu sih di episode kali ini. apa bener Nge-Vape aman? simak data-data dan fakta di dunia kedokteran di episode ini daaaaaaan, lagi-lagi yudhis lupa mulu mau bikin sosial media buat Biopsci, jadi kalian sementara follow dulu aja podcastnya di Spotify, google Podcast, Anchor, Breaker, Pocket Cast, dan iTunes dulu yaaaa. atau kalian bisa juga sih kontak ayu dan yudhis langsung di Instagramnya yaitu di @ayuafrilya dan @kamuinii (iya, yudhis ganti username) atau kalo kamu prefer the old way kayak kaya darkseid, bisa hubungi mereka di biopscipodcast@gmail.com stay safe guyyssss!!

Ever wonder why "that" person walking in public has such an impressive cloud of smoke around them? If it doesn't stink like weed, chances are that cloud you're seeing is from a vaping device. In today's episode, we explore the world of vaping: its popularity, the reasons why people are turning to vaping, how to vape, the 4 different generations of vapes, the street lingo, its safety compared to cigarettes, and the potential health risks. Learn why EVALI is a life threatening medical condition specific to vaping.  Music : "Curious" is performed by Bonsai Mammal, written by Andrew Southwell and Jimmy Harry. --- Support this podcast: https://podcasters.spotify.com/pod/show/itisbettertoknow/support

With the door now finally shut on the disastrous year of 2020, it's time to reflect on how vaping and tobacco harm reduction in general, faired during a year that brought massive upheaval to the lives of so many. At the epicentre of the turmoil is the public health movement and as so often is the case, its intersection with politics. Joining us today on RegWatch is Greg Conley the president of the American Vaping Association. Hear Conley's take on which disaster caused more damage to the U.S. vaping industry: the scare over the so-called teen vaping epidemic, EVALI, or the response to the pandemic. And hear his detailed warning about the recently passed vape mail law that bans U.S. Mail shipments of vaping products and forces online vape sellers to comply with an unwieldy tax mandate. Only on RegWatch by RegulatorWatch.com. Released: January 16, 2021 Produced by Brent Stafford This episode is supported by DEMAND VAPE https://youtu.be/ArBbkUz_APo Make RegWatch happen, go to https://support.regulatorwatch.com  

FDA 连续批准2个针对MET外显子突变的非小细胞肺癌的靶向药NEJM 关于电子烟相关急性肺损伤的住院与死亡的报告Nature 抑制淋巴毒素β受体可诱导肺再生卡马替尼（capmatinib）在非小细胞肺癌患者中，MET外显子14跳跃突变发生在3~4%、MET扩增发生率1~6%。卡马替尼是一种选择性的MET受体抑制剂，在具有不同类型MET激活的癌症模型中显示出活性。2020年5月，FDA批准卡马替尼用于MET外显子14跳跃突变的非小细胞肺癌的一线治疗。《GEOMETRY mono-1研究：卡马替尼治疗MET外显子14突变或MET扩增的非小细胞肺癌的2期临床研究》New England Journal of Medicine，2020年9月 (1)参与者为364名晚期非小细胞肺癌患者，根据既往治疗和MET状态分组，接受卡马替尼治疗。其中MET外显子14跳跃突变的患者中，曾接受过治疗的整体缓解率41%，未接受过治疗的缓解率68%，中位缓解时间分别为9.7个月和12.6个月。在MET扩增的患者中，疗效有限。MET基因拷贝数

FDA 连续批准2个针对MET外显子突变的非小细胞肺癌的靶向药NEJM 关于电子烟相关急性肺损伤的住院与死亡的报告Nature 抑制淋巴毒素β受体可诱导肺再生卡马替尼（capmatinib）在非小细胞肺癌患者中，MET外显子14跳跃突变发生在3~4%、MET扩增发生率1~6%。卡马替尼是一种选择性的MET受体抑制剂，在具有不同类型MET激活的癌症模型中显示出活性。2020年5月，FDA批准卡马替尼用于MET外显子14跳跃突变的非小细胞肺癌的一线治疗。《GEOMETRY mono-1研究：卡马替尼治疗MET外显子14突变或MET扩增的非小细胞肺癌的2期临床研究》New England Journal of Medicine，2020年9月 (1)参与者为364名晚期非小细胞肺癌患者，根据既往治疗和MET状态分组，接受卡马替尼治疗。其中MET外显子14跳跃突变的患者中，曾接受过治疗的整体缓解率41%，未接受过治疗的缓解率68%，中位缓解时间分别为9.7个月和12.6个月。在MET扩增的患者中，疗效有限。MET基因拷贝数

Dr. Michael Gotway discusses the signature signs of EVALI -- lung injuries related to e-cigarettes or vaping -- in CT scans in this podcast.

I was asked by a patient: "Should I use e-cigs to stop smoking?" It's not a simple question. Here's my answer that explores the benefits and risks of e-cigs/vaping, the risk of EVALI, lung disease, and nicotine addiction (especially in youth) and special considerations during the COVID-19 pandemic. Enjoy! Brain Health with Dr. Nissen brings you advancements in medicine, #neuroscience, psychiatry, and #nutrition to help you live a better life. Dr. Nissen's expert interviews reveal new, evidence-based approaches to enhancing mental health, sharpening cognition, and optimizing performance. With topics such as #optogenetics, #Alzheimer's disease, #neuromodulation, #depression, the Mediterranean #Diet, and #psychedelics, this show is sure to expose listeners to new topics on the frontiers of medicine and neuroscience. Join our community at http://drnissen.com Support us on Patreon: https://www.patreon.com/drnissen Subscribe to the podcast at https://podcasts.apple.com/us/podcast/brain-health-with-dr-nissen/id1510757864 Dr. Nissen is a medical doctor (MD) and therapist. This show is intended for entertainment and educational purposes only and does not substitute personalized medical advice. Please speak with your doctor before attempting any medical or major diet and lifestyle changes. Check out Dr. Nissen's new children's book on empathy and emotional intelligence, Emily Empathy! http://bit.ly/emilyempathy

Dr. Reagan-Steiner and Dr. Gary about pathlogical findings in suspected cases of e-cigarette, or vaping, product use-associated lung injury, or EVALI.

*Guest: Dr. Derek Yach, President of Foundation for a Smoke-Free World Not long ago, tobacco control researchers and public health officials openly discussed a possible worldwide “endgame” to combustible tobacco use, thus preventing the death of up to one billion smokers by end of this century. But today, the focus on endgame is forgotten as the tobacco control movement intensifies efforts to eradicate vaping, the only technology proven both scalable and appealing to smokers as a viable alternative to smoking. Tobacco control fixates on preventing up-take of smoking and complete cessation of nicotine use. While technologies like vaping, represent the principles of reduced risk and harm reduction. Joining us today on RegWatch is Dr. Derek Yach, President of the Foundation for a Smoke-Free World (FSFW) and former World Health Organization (WHO) cabinet director and executive director for noncommunicable diseases and mental health where he was deeply involved with the development of the world's treaty on tobacco control, the Framework Convention on Tobacco Control (FCTC). At the forefront of global debate, hear Dr. Yach discuss the promise of tobacco harm reduction; why the WHO appears so vehemently opposed to harm reduction strategies; and whether increasing attacks on vaping (science and policy) and the reaction to crisis (youth epidemic, EVALI, and COVID19) have increased harm due to tobacco-related disease. Only on RegWatch by RegulatorWatch.com Live Streamed: June 17, 2020 Sr. Producer: Cindy Schmidt Exec. Producer: Brent Stafford Make RegWatch happen, go to: support(dot)regulatorwatch(dot)com https://youtu.be/3Vo9D6CUjpE

Vaping associated lung injury exploded into a public health crisis in 2019 in the United States and the introduction of a new term into the medical lexicon – EVALI. This episode briefly explores the history of vaping, the authors' experiences that led to this manuscript, and an update on what has changed since we first went to publication. For more on this, read Travis Henry's article in the March issue of AJR: https://www.ajronline.org/doi/full/10.2214/AJR.19.22251

Go to inmygrow.com to SUBSCRIBE to the show or find us on the Stitcher app. Email us at inmygrow@gmail.com Find us on Instagram @inmygrow  Click here to go to 101cbd.org Go to DeltaLeafLabs.com to order your “Plant DNA Sex Testing Kits” Click Here for the Amazon link to help support the show. Show Notes: Greetings and welcome to show 91 and to first show of 2020.  I meant to do a show before the new year last week but my daughter got sick.  Recap of the year, things we did and didn't do. I decided not to do video episodes this year because when it's just me it's really boring.  I also didn't finish my cookbook, I have half the recipes I need for it. Got my notes from the Ojai Herbal Symposium. One last thing, birthday shout to Kristen from SBVerde. Strain of the Week:   Lowell Farms 5 pack of pre-rolled, the comfort indica.  They were a blend of Super Glue x Josh D OG. The package said 21% THC but it didn't feel like that to me, I got to be honest I was unimpressed.  Both by the high and the flavor which was bland. On top of that all 5 of those joints were runners. I like some of Lowell Farms flower, but when it comes to these pre-rolled I'm not a fan.    The other stain is the Mango Brulee  Sativa-Dominant, citrus, floral and mango, positive and focused, daytime “Top Shelf” hybrid coupling of Mango and Blue Dream.  It had a flowery smell in the jar and had a really fruity, sweet taste, not like mango but pineapple to me. It was a nice high, not to heavy 18% THC.  And it was put together by the Monterey Kush Co. and I picked that up at the Hueneme Patient Collective down in Oxnard. I want to wrap that up by giving a pot smoker tip of the week.  If your bud gets dry you rehydrate it in a few different ways. Cannabis leaf, piece of tortilla or orange peel.  Don't put a wet cotton ball or tissue in with it, could cause condensation and cause mold.       Things I want in 2020:  Cannabis rescheduled federally and more consumption lounges near me.    Social Media:  Dr. Jake Felice will be giving a presentation about the “endocannabinoid system” on Jan. 13 at Sesepe Creek Collective at 408 Bryant Crl. suite C. in Ojai.     Arroyo Verde Farms which is a cannabis cultivation farm out in Carpinteria Ca. are having community day tour on Sat. Jan 18.  I picked up the free tickets for this event in the Bio of their IG account @arroyoverdefarms.   Quarterly Cannabis workshop and network event is on Jan 8. Wed at the Carr Winery 414 N Salsipuedes, in SB.  The topics are (The Social Entrepreneur, How Compliance Testing Legitimizes the Industry and Federal Cannabis Legislation Report from the cannabis front line LG has made a grow cabinet - https://www.cnet.com/news/lgs-herb-fridge/  The President and cannabis - https://www.forbes.com/sites/tomangell/2019/12/21/trump-says-he-can-ignore-medical-marijuana-protections-passed-by-congress/#51081ac44256  Skip the line in Chicago - Sunnyside dispensary in Chicago is offering people the chance to skip the lines on the first day of legal marijuana sales for $250, with proceeds going to the nonprofit The Last Prisoner Project. https://giftofhistory.sunnyside.shop/  Italy and home grows - https://www.reuters.com/article/us-italy-cannabis-ruling/italy-court-rules-home-growing-cannabis-is-legal-reigniting-dispute-idUSKBN1YV14H  Big Cannabis stories of 2019:   Vaping lung disease a.k.a e-cigarette, or vaping, product use-associated lung injury (EVALI). Phylos Bioscience Legalizing hallucinogenic The rise of cannabis/Hemp and clash between communities and industry. The Black Market and the high cost of regs and taxes in Ca. Big thanks to:  All the artist for letting me use their music and to DJ Monstr Drop for helping out with some of the social media stuff.   Support the show - Go to Patreon.com and find the In My Grow Show and donate what you can. “In My Grow Show - Grow Learn Teach” T-shirts are here for you.  to check it out.  CLICK HERE check it out.  Music: Silent Partner - Butchers Shaolin Dub - Billowing Smoke

Drinking water: alkaline, thirst, bottled, lead // Interview with Olivier Bernard (thepharmafist.com) on vitamin C, harassment, and winning the John Maddox Prize // Vaping update: EVALI and popcorn lung   * Vox pop by Sarah Swinwood * Jingle by Jillian Correia of Roctavio Canada * Additional music by Seth Donnelly and Kevin MacLeod of Incompetech.com. * Theme music: "Troll of the Mountain Swing" by the Underscore Orkestra.   To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.   Patrons get a bonus show on Patreon called “Digressions”! Check it out!   References: 1) The JAMA study on water intake and kidney function: https://jamanetwork.com/journals/jama/fullarticle/2680548 2) Filter numbers: http://info.nsf.org/Certified/DWTU/listings_leadreduction.asp; http://www.nsf.org/consumer-resources/water-quality/water-filters-testing-treatment/standards-water-treatment-systems 3) Places where you can test your water in Quebec: http://www.ceaeq.gouv.qc.ca/accreditation/PALA/lla03.htm?fbclid=IwAR2u1zqvmnb03uklvROVsjCPsLqljFdUcjO2qv3tM0XMyQJhRCRzLokkCMA#outaouais 4) SWET Trial: https://www.ncbi.nlm.nih.gov/pubmed/21324289  

Patients have been using cannabis for much longer than scientists have been seriously studying its medical value and applications. Of course there's no substitute for clinical trials, but that doesn't mean we should dismiss patient experience as merely anecdotal, Tilray's VP of patient research, Philippe Lucas, says.“We have 10 clinical studies either completed or underway, but we're also equally committed to gathering real world evidence,” Lucas explains of his company's dual approach to researching medical cannabis. “Ultimately patients can tell us a lot about what works best for specific conditions or what dosages are most effective.”What does successful cannabis legalization look like? Medical cannabis has been legal in Canada for nearly 20 years and recreational for over a year, and that experience can be of immense value.“I don't want [the rest of the world] to just learn from our successes, they have a lot to learn from our failures,” Lucas says of the lessons Canada's legalization holds for other countries considering a similar path.Make sure to stick around until the end of the episode [33:50], where we sit down with Dr. Roni Sharon to get a physician's perspective on the vaping crisis that has killed at least 47 people. Listen to hear how that has changed some doctors' approach to prescribing cannabis.“It's a big dilemma for us prescribers because it's actually one of the best ways of prescribing cannabis for patients,” Dr. Sharon says.This episode was produced by Elana Goldberg and Matan Weil, edited by Michael Schaeffer Omer-Man, and Yoav Morder was the sound engineer. Music by Desca.

Go to inmygrow.com to SUBSCRIBE to the show or find us on the Stitcher app. Email us at inmygrow@gmail.com Find us on Instagram @inmygrow  Click here to go to 101cbd.org Go to DeltaLeafLabs.com to order your “Plant DNA Sex Testing Kits” Click Here for the Amazon link to help support the show. Show Notes: Welcome to the In My Grow Show, I'm Alex.  Later I'm going to talk about the CBD Expo.  I've notice I say “like I was saying” or “as I said” a lot.  Let's turn it into a smoking game, when you hear me say it you gotta toke.  I'll save my tokes for the end, i can't do the show high I get lost on notes really easy.   Strain of the Week which is sponsored by Sespe Creek Collective :  white buffalo - is an 80/20 sativa-dominant cannabis strain that descends from a Romulan and a Blackberry Kush/Bay 11.  It has this fruity, piney, gassy taste to it and the high builds. It took about 15min to feel the full effects of it, sometimes weed this strong will hit me all at once (26% thc).  Made me feel nice and chatty and easily distracted, wanting to talk to everyone. My wife said that was called being “social”. Lemon Tree - is a hybrid cross of Lemon Skunk and Sour Diesel.  It was a very sedative flower for me, (23% thc indica hybrid) it didn't make me sleepy but it did relax me and slow me down. Not good for day time use, definitely end of day kind of thing. It had a lemon pepper taste to it.  Felt nice and supple when I opened the jar, sometimes weed can be super dry. If your into indicas, this one's for you. I picked both of those up at Sespe Creek Collective 408 Bryant Circle Suit C      Social Media:  I checked out an terpen oxygen bar (about 21% oxygen in the air) that was at Sespe Creek put on by bloom farm.  They had Humulene, Limonene, Linalool and Terpineol. Oxygen bars always seemed gimmicky to me but since it was free, I sat down and had me some pure oxygen.  -2nd annual Ojai Herbal Symposium November 16-17, 2019, at Krotona Hall and this year's theme, “The Wisdom of the Body,”.  In addition to two full days of talks at beautiful Krotona Hall, the weekend also will feature: Herbal Marketplace at Chaparral Auditorium in downtown Ojai PhytoPhunk Dance and Elixir Bar at Greater Goods in Meiners Oaks The Forest Table: A Wild Food Dining Experience at Fisher Hall in downtown Ojai I'm going to go see my buddy Dr.Jake Felice because he is one of the presenters that weekend.   Click here for more detail Ojiaherbal.org Report from the cannabis front line cannabis use disorder (CUD) https://www.marijuanamoment.net/problematic-marijuana-use-is-declining-among-people-who-consume-every-day-study-finds/  CDC and EVALI https://blog.norml.org/2019/11/08/cdc-identifies-vitamin-e-oil-additive-as-a-very-strong-culprit-of-concern-in-vaping-related-lung-injuries/  CBD Expo experience   Support the show - Go to Patreon.com and find the In My Grow Show and donate what you can. “In My Grow Show - Grow Learn Teach” T-shirts are here for you.  to check it out.  CLICK HERE check it out.  Music: Silent Partner - Butchers                        - 7th Floor Tango

Authors from a new case series talk about the development of an algorithm they developed for the diagnosis and treatment of e-cigarette or vaping product use-associated lung injury, or EVALI.

Host Kevin Patton previews the newly revised HAPS Learning Outcomes for A&P, discussing the goals of the revision and samples a few of the changes. Why is noon a good time to get your flu shot? Are there neurons that actively erase memories? Vaping: why A&P teachers need to keep up with the news. 00:42 | Timing of Vaccinations 02:36 | Sponsored by HAPS 03:04 | Neurons That Erase Memory 08:22 | Sponsored by AAA 08:47 | Vaping 13:45 | Sponsored by HAPI Online Graduate Program 14:28 | Revisiting the HAPS Learning Outcomes for A&P 41:43 | Staying Connected If you cannot see or activate the audio player click here. Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!   It is what we think we know already that often prevents us from learning. (Claude Bernard)   Timing of Vaccinations 2 minutes With a new flu season upon us, vaccination is a timely topic. Recent research suggests that the time of day at which we receive our vaccination may influence it's effectiveness. At midday, CD8 T cells may respond more strongly than at other times of day. Immune cells called T cells multiply after vaccination in the middle of the day. (journal news article) my-ap.us/2LOv2tN The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways (journal research article) my-ap.us/2OkPGTY Australia Just Had a Bad Flu Season. That May Be a Warning for the U.S. (news article) my-ap.us/2OmPC6n Frequently Asked Influenza (Flu) Questions: 2019-2020 Season (CDC info) my-ap.us/33oTN5H Weekly U.S. Influenza Surveillance Report — Flu View (CDC updates) my-ap.us/326MEa2     Sponsored by HAPS 0.5 minute The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast.  You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. There are a bunch of 1-day regional workshops scattered all over the continent. There's probably one near you coming up this year (or next)! Anatomy & Physiology Society theAPprofessor.org/haps     Neurons That Erase Memory 5.5 minutes New evidence suggests that there is a population of neurons that actively erase old, unimportant memories during REM sleep. Hopefully, your memories of past episodes of this podcast will be preserved (as well as the date of my birthday). Scientists Identify Neurons That Help the Brain Forget: In mice, cells in the hypothalamus clear out old memories while the animals sleep. (news article) my-ap.us/2OkxEkV REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories (journal report) my-ap.us/2MfVyvl     Sponsored by AAA 0.5 minutes A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org. Searchable transcript Captioned audiogram      Vaping 5 minutes Vaping is a timely topic, considering the emergence of vaping-induced lung injury and other vaping-related conditions. Discussing the news about vaping, which is frequently updated, is appropriate in the A&P course. Following the story over the course of a year may helps students better understand human science. Vaping Illnesses Top 1,000, C.D.C. Says (news article) my-ap.us/2MgPUZL Lung Damage From Vaping Resembles Chemical Burns, Report Says (news article) my-ap.us/2IoMZxa Vaping-Induced Lung Injury (journal editorial) my-ap.us/2MhP2UH The Health Effects of Electronic Cigarettes (journal review article) my-ap.us/2OnST5b How Vaping Nicotine Can Affect A Teenage Brain (print/audio news story) my-ap.us/32b5OvG CDC Vaping Information (search results showing current information) my-ap.us/2Mch70I A Young Man Nearly Lost His Life to Vaping (newspaper article) my-ap.us/2qfkdZn Vaping-related illness has a new name: EVALI (news article) my-ap.us/2MOaUau Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury — United States, October 2019 (CDC update) my-ap.us/33Cag6U     Sponsored by HAPI Online Graduate Program 1 minute The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you power up  your teaching. Kevin Patton is a faculty member in this program. Check it out! nycc.edu/hapi     Revisting the A&P Learning Outcomes from HAPS 27 minutes HAPS recently released its revised Learning Outcomes for A&P. It's a significant revision, with many improvements. Kevin discusses some of the changes and gives advice on how to navigate and use them in your course. HAPS Learning Outcomes (download page for outcomes and white paper; requires login) my-ap.us/2noTclo Module titles: A: Body Plan & OrganizationB: HomeostasisC: Chemistry & Cell Biology D: Histology E: Integumentary System F: Skeletal System & Articulations G: Muscular System H: Nervous System I: General and Special Senses J: Endocrine System K: Cardiovascular System L: Lymphatic system and immunity M: Respiratory System N: Digestive system O: Nutrients & Metabolism P: Urinary System Q: Fluid/Electrolytes & Acid-Base Balance R: Reproductive System S: Introduction to Heredity T: Embryology   If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available at the script page. Listen to any episode on your Alexa device. Need help accessing resources locked behind a paywall? Check out this advice from Episode 32 to get what you need! https://youtu.be/JU_l76JGwVw?t=440   Sponsors   Transcript and captions for this episode are supported by the  American Association for Anatomy. anatomy.org     The Human Anatomy & Physiology Society  also provides marketing support for this podcast.  theAPprofessor.org/haps     Distribution of this episode is supported by  NYCC's online graduate program in  Human Anatomy & Physiology Instruction (HAPI)  nycc.edu/hapi   Clicking on sponsor links  helps let them know you appreciate their support of this podcast!   Referrals also help defray podcasting expenses.  Amazon TextExpander Snagit & Camtasia The A&P Professor Logo Items   Follow The A&P Professor on  Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram!   The A&P Professor® and Lion Den® are registered trademarks of Lion Den Inc. (Kevin Patton)  

How much do we depend on apps and websites and how much money would we pay to use them if we had to? A new study reveals the shocking amounts! SHOW OPEN When Frank is corrected, he'll hold on to that for a week and then randomly text you when you're wrong. (11:32) Panera Bread employee fired after posting video 'exposing' how mac 'n' cheese is prepared (16:00) How Much Money Would It Take to Get You to Give Up Facebook, YouTube, or Google? (25:25) Dumbass Of The Day A 20-Year-Old Was Busted for Using a "McLovin" ID to Drink at a Bar A security guard in Wisconsin had to call the cops for help after he got bored and handcuffed himself A predator from Indiana walked 350 miles to Wisconsin to meet up with an underage girl.  But it was actually an FBI sting, and he was arrested. A Guy Calls 911 Because His Roommate Stole $20 of His Weed Naked home intruder, wearing only a bra and panties, arrested in El Dorado Hills (42:00) Crotch Talk! Warning from Doctors: Do Not Use Toothpaste on Your Lady Parts A veteran who lost his genitalia in an explosion in Afghanistan has received one of the world's first penis transplants. Teenager with TWO vaginas, wombs and cervixes says it took doctors eight years to spot her unusual anatomy after they repeatedly dismissed her excruciating period pains (52:50) There's a new name for Vape Lung, and it sounds fancy! The CDC has given a new name to illnesses caused by vaping:  EVALI.  It stands for "e-cigarette, vaping, lung injury." (58:40) Frank's Family Football Night Frank gets tickets to see Wildcats Football and decides to take the whole family....What could go wrong? Support the show: https://podcave.app/subscribe/the-world-famous-frank-show-4eehjczc See omnystudio.com/listener for privacy information.