Podcasts about by way

Piers Morgan Uncensored takes a deep dive into the good, the bad and the ugly history of Israel's intelligence agency, known as the Mossad. Does Israel have nuclear weapons? Was Jeffrey Epstein a Mossad agent? Why didn't they see the October 7 attack by Hamas coming? Piers Morgan delves into all this and more with former Head of Mossad Danny Yatom, former CIA agent and convicted whistleblower John Kiriakou, criminal defense lawyer Alan Dershowitz and author of ‘Provoked' and ‘By Way of Deception' Scott Horton. Uncensored is proudly independent and supported by: Tax Network USA: Call 1-800-958-1000 or visit https://TNUSA.com/PIERS to meet with a strategist today for FREE American Hartford Gold: Protect your wealth with precious metals! Call American Hartford Gold today & get up to $15,000 in free silver on your 1st order! Call 866-692-2474 or Text PIERS to 65532, or Click the link below: https://offers.americanhartfordgold.com/piers-morgan/ Learn more about your ad choices. Visit megaphone.fm/adchoices

We spend our 50th episode (the last of this season) with communication theorist Amit Pinchevski. Amit's recent book Echo (MIT Press) explores its topic through mythology, etymology, history, technology, and philosophy. The book challenges the notion that echo is mere repetition. Instead, Pinchevski argues, echo is a generative medium that creatively expresses our relations to others and the world around us. Just as a baby first learns to speak by repeating the sounds of others, a philosophy of echoes reminds us that our own agency and creativity reside in repetitions that respond to the past.  For our Patreon members we the full two-hour conversation with Amit's “What's Good” segment. Join at patreon.com/phantompower.  Amit Pinchevski is Associate Professor in the Department of Communication and Journalism at the Hebrew University of Jerusalem. His research interests are in theory and philosophy of communication and media, focusing specifically on the ethical aspects of the limits of communication; media witnessing, memory and trauma; and pathologies of communication and their construction. He is the author of By Way of Interruption: Levinas and the Ethics of Communication (Duquesne UP, 2005), Transmitted Wounds: Media and the Mediation of Trauma (Oxford UP, 2019), and Echo (MIT Press, 2022). He is co-editor of Media Witnessing: Testimony in the Age of Mass Communication (with P. Frosh; Palgrave, 2009) and Ethics of Media (with N. Couldry and M. Madianou; Palgrave, 2013). His work has appeared in academic journals such as Critical Inquiry, Philosophy and Rhetoric, Cultural Critique, Cultural Studies, Public Culture, New Media & Society, and Theory, Culture & Society. Today's show was written and edited by Mack Hagood.  Original music by Graeme Gibson Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sound-studies

In the wake of the recent Pokemon Presents video, Jonathan and Ryan run through most of the highlights of the video including the new game Pokemon Legends Z-A, the new cards, and Pokemon Champions for Switch and Phones. Later, Ryan gives his reviews of several games such as Kero Blaster, Box Boy & Box Girl, Terminator 2D, and Poppy's Playtime. There's also tons of cat chat.0:00:00 - Feeling Miserable Suddenly0:01:58 - Pokemon Presents Pokemon Day0:04:43 - Pokemon Champions for Switch and Phones0:05:07 - Puggymin Cards0:06:08 - Starting a Cat Podcast?0:06:59 - Little Kitty, Big City0:07:19 - Poppy's Playtime0:10:31 - Jonathan's Urban Legends0:13:02 - Ryan's Review of Terminator 2 (Film)0:15:05 - An Important Thought0:16:15 - The Next Topic0:16:31 - Big Kitty, Little City, By Way of Balatro, By Way of Poker0:17:55 - Shovel Knight's Joustus0:18:59 - The Shovel Knight Concert that Almost Was0:19:36 - Back to Pokemon Legends Z-A0:21:30 - Giving the People What They Want0:23:02 - Back to Pokemon Legends Z-A Again0:25:35 - Ryan's Review Roundup (Kero Blaster, Box Boy & Box Girl, Terminator 2D, Poppy's Playtime)0:29:35 - That's Just Like Your Opinion, Man0:32:28 - See Ya Next Time!

We welcome three people integral to the planning of the Harriet Tubman Byway, a proposed 550-mile cultural heritage tourism route in New York State, crossing over 22 counties with aim to connect sites related to Harriett Tubman and the Underground Railroad.

Today's broadcast is C1E90 for Theme Thursday, November 21st  2024. Today's Broadcast is part 2 of a 2 part series on music from 100 of Hugues' favorite games as a part of his "farewell tour" to podcasting – 50 apiece for the occasion of his upcoming 50th birthday – curated, produced, and hosted by Hugues himself - on a program we're calling "Turning 50 – The B-Sides"    Tracklist!     Track# / Track / Game / System / Composer(s) / Timestamp     A1) Earcatcher - 00:00:00     A2) Intro - 00:01:35     01) Overworld - Legend of Zelda - NES - Koji Kondo - 00:03:37     02) Forest of Elrond - Wizards and Warriors - NES - David Wise - 00:04:19     03) Swimming - Alex Kidd in Miracle World - Master System - 00:05:40     04) Track 2-3 - Super Mario Bros - NES - Koji Kondo - 00:08:10     05) Chill - Dr. Mario - NES - Koji Kondo - 00:08:10     06) Town - Phantasy Star - Master System - Tokuhiko Uwabo - 00:12:30     07) Passing Breeze - Outrun - Arcade - Hiroshi Kawaguchi - 00:13:50     08) Theme - Space Harrier - Arcade - Hiroshi Kawaguchi - 00:19:30     09) Green Hill Zone - Sonic the Hedgehog - Genesis - Masato Nakamura - 00:27:00     10) Field of Gale - Ys V - Super Famicom - Falcom Sound Team JDK (Atsushi Shirakawa) - 00:29:19     11) Library of Ancients - Final Fantasy V - Super Famicom - Nobuo Uematsu - 00:32:23     12) Behind the Circuit - Phantasy Star IV - Genesis - Izuho Takeuchi and/or Masaki Nakagaki - 00:34:53     13) Tenth Street - Shadownrun - SNES - Marshall Parker - 00:37:15     14) Wilderness - Golden Axe - Genesis - Tōru Nakabayashi - 00:41:10     15) Vega's Theme - Street Fighter II - Arcade - Yoko Shimomura - 00:46:07     16) In the Bar - Streets of Rage 2 - Genesis - Yuzo Koshiro and/or Motohiro Kawashima - 00:48:42     17) China Town - Revenge of Shinobi - Genesis - Yuzo Koshiro - 00:50:03     18) Onett - Earthbound - SNES - Keiichi Suzuki and/or Hirokazu “Hip” Tanaka - 00:52:40     19) Kakariko Village - LoZ: Link to the Past - SNES - Koji Kondo - 00:53:51     20) Town - Legend of Heroes - TG16 - Falcom Sound Team JDK (Meiko Ishikawa) - 00:55:53     21) Track 8 - Dungeon Explorer II - TG16 - Tsukasak Masuko - 01:00:02     22) Track 3 - Splash Lake - TG16 - T's Music - 01:01:59     23) Celceta: The Sea of Trees - Ys IV - PC Engine - Falcom Sound Team JDK (Atsushi Shirakawa) - 01:05:01     24) Vampire Killer - Castlevania: Rondo of Blood - PC Engine - Akira Sōji, Keizō Nakamura, Tomoko Sano, and/or Mikio Saitou - 01:06:59     25) Collision Chaos (Present) - Sonic CD (N/A) - Sega CD - Spencer Nilsen, David Young, Mark Crew and/or Pastiche - 01:08:35     26) Ending - Popful Mail - Sega CD - Falcom Sound Team JDK (Atsushi Shirakawa) - 01:10:14     27) DK's Island Theme - Donkey Kong 64 - N64 - Grant Kirkhope - 01:12:10     28) Frontier Village Dali - Final Fantasy IX - PS1 - Nobuo Uematsu - 01:15:56     29) Safe in Beregost - Baldur's Gate - PC - John Winski - 01:18:16     30) Stone Tower Temple - LoZ: Majora's Mask - N64 - Koji Kondo - 01:19:37     31) Cosmo Canyon - Final Fantasy VII - PS1 - Nobuo Uematsu - 01:21:29     32) Crossing3084 - Phantasy Star Online - Dreamcast - Hideaki Kobayash and/or Fumie Kumatani - 01:24:59     33) Area 1: Mother Nature - Dig Dug Arrangement - Arcade - c: Yuriko Keino / a: Unknown - 01:28:59     34) Not Mega… - Retro City Rampage - Vita - Jake Kaufman - 01:31:02     35) Commercial City of Liligue ~ Pretense of Prosperity - Grandia II - PS2 - Noriyuki Iwadare - 01:32:51     36) The Byway of Departure - Trails in the Sky - PSP - Falcom Sound Team JDK (Wataru Ishibashi) - 01:35:34     37) Lonely Rolling Star - Katamari Damacy - PS2 - Yoshihito Yano - 01:37:35     38) Comic Klepto - Bully - PS2 - Shawn Lee - 01:43:14     39) Traces of D - Trails to Azure - PSP - Falcom Sound Team JDK (Saki Momiyama) - 01:45:54     40) Beautiful Morning - Danganronpa 2 - PSP - Masafumi Takada - 01:47:55     41) Lanayru Mining Facility - LoZ: Skyward Sword - Wii - Hajime Wakai, Shiho Fujii, Mahito Yokota, Takeshi Hama, Kōji Kondō - 01:50:51     42) The Island Left Behind - Legend of Nayuta - PSP - Falcom Sound Team JDK (Saki Momiyama) - 01:53:59     43) Flower Fields - Kirby's Epic Yarn - Wii - Tomoya Tomita - 01:56:19     44) Anya by the Stars - To the Moon - PC - Ken Gao and/or Laura Shigihara - 01:59:48     45) Genial and Balmy - Trails of Cold Steel III - PS4 - Falcom Sound Team JDK (Takahiro Unisuga) - 02:01:57     46) AfroCuban-Taco Restaurant - Save the Date - PC - Francisco Cerda - 02:04:28    47) Tokyo Daylight - Persona 5 - PS4 - Shōji Meguro - 02:07:55     48) Hammerhead - Final Fantasy XV - Multiplatform - Yoko Shimomura - 02:09:54     49) Gentle Tiny Sleep - Trails of Cold Steel IV - PS4 - Falcom Sound Team JDK (Hayato Sonoda) - 02:14:01     50) Flamesgrace, Guiding Light - Octopath Traveler - Multiplatform - Yasunori Nishiki - 02:16:14    Music Block Runtime: 02:16:46, Total Episode Runtime: 02:20:23    Hugues' blog can be found here:      https://huguesjohnson.com/    You can also find all of our audio episodes on https://archive.org/details/@nerd_noise_radio as well as the occasional additional release only available there, such as remixes of previous releases and other content.    Our YouTube Channel, for the time being is in dormancy, but will be returning with content, hopefully, in 2022. Meanwhile, all the old stuff is still there, and can be found here:     https://www.youtube.com/user/NerdNoiseRadio    Occasional blogs and sometimes expanded show notes can be found here:    nerdnoiseradio.blogspot.com.    Nerd Noise Radio is also available on The Retro Junkies Network at www.theretrojunkies.com, and is a member of the VGM Podcast Fans community at     https://www.facebook.com/groups/VGMPodcastFans/    We are also a member of Podcasters of Des Moines at https://www.facebook.com/groups/1782895868426870/    Or, if you wish to connect with us directly, we have two groups of our own:     Nerd Noise Radio - Easy Mode: https://www.facebook.com/groups/276843385859797/ for sharing tracks, video game news, or just general videogame fandom.    Nerd Noise Radio - Expert Mode: https://www.facebook.com/groups/381475162016534/ for going deep into video game sound hardware, composer info, and/or music theory.    Or you can reach us by e-mail at nerd.noise.radio@gmail.com    You can also follow us on X (Twitter) at https://twitter.com/NerdNoiseRadio , Threads at https://www.threads.net/@nerdnoiseradio , Instagram at https://www.instagram.com/nerdnoiseradio?igsh=MWF4NjBpdGVxazUxYw== , Mastodon at https://universeodon.com/@NerdNoiseRadio , and BlueSky at  And we are also now on Spotify, TuneIn, Pandora, iHeartRadio, Vurbl, Amazon Music and Audible! There is technically a Discord channel, but we may or may not ever take it public!    Thanks for listening! Join us again in Later this month or early December for C2R4 (Channel 2, Retrospective 4): "The Best of Season 4" and in December for C2F (Channel 2 Finale): "Finally our Final Finale", the series retrospctive and final broadcast of Channel 2 as well as for C1R7 (Channel 1, Retrospective 7) - Delicious VGM on "Noise from the Hearts of Nerds", and for the the last times, Tasty VGM and Talk on Nerd Noise Game Club. And wherever you are - Fly the N!    Cheers! 

Explore the Grant Wood Scenic Byway!Join us as we ride through Iowa's Grant Wood Scenic Byway, celebrating the landscapes that inspired the famed artist of "American Gothic." From twisty roads to hidden gems like Ollie's Garage and breathtaking views in Bellevue, discover our best day ride yet!Disclaimer: This video is not sponsored. Some product links are affiliate links, meaning we may earn a small commission if you make a purchase.Episode HighlightsBottom Line: A fantastic day trip on the Grant Wood Scenic Byway.Mile Marker: Follow our journey through Iowa, from Solon to Makoketa, Bellevue, and beyond, including stops at state parks and historical spots.Toolkit: Drone tips and gear insights! Hear our thoughts on using drones to capture perfect riding shots and recommendations for drone controllers and portable designs.⏰ Timecodes0:00 - Introduction to Grant Wood Scenic Byway1:00 - Historical Overview of Grant Wood3:00 - Exploring Ollie's Garage in Goose Lake, IA4:00 - Views of the Mississippi from Bellevue State Park7:00 - Makoketa Caves State Park & Decker Hotel in Makoketa9:00 - Codfish Hollow: An Iowa Music Venue Like No Other12:00 - Final Stretch: Oxford Junction to Anamosa15:00 - Toolkit Segment: Drone Use in Motorcycling17:00 - Wrap Up and Closing ThoughtsMentioned LinksGrant Wood Scenic Byway Travel Info: https://www.traveliowa.com/trails/grant-wood-scenic-byway/5/Featured Toolkit Gear: DJI Drones - https://amzn.to/3AJeyj3Connect with Us!YouTube: https://www.youtube.com/@BestMotorcycleRoadsFacebook: https://www.facebook.com/motorcycleroadsandtripsInstagram: https://www.instagram.com/bestmotorcycleroads/Best Motorcycle Roads Podcast: https://bestmotorcycleroads.com/podcast/Join our BMR Rider Alerts for updates: https://bestmotorcycleroads.com/rideralert/Question of the EpisodeWhat's your favorite scenic byway or day ride destination? Share your go-to spot in the comments!Don't Miss Out!If you enjoyed this episode, hit that subscribe button and sign up for our BMR Rider Alerts to stay in the loop on new rides and routes. And as always, keep the spirit of adventure alive—bikes, friends, and endless roads!#GrantWoodByway #MotorcycleAdventure #BestMotorcycleRoads #IowaByways #RiderAlerts #AmericanGothic

Below is a brief video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! This one has embedded one of my favorite TikTok's from Will. There are several links to others in the transcript. The audios are also available on Apple and Spotify.Transcript with links to both audio and videos, commencement addresses, NEJM article coverageEric Topol (00:06):Hi, it's Eric Topol from Ground Truths, and I've got an amazing couple with me today. It's Will Flanary and Kristin Flanary, the Glaucomfleckens. I've had the chance to get to know them a bit through Knock Knock, Hi! which is their podcast. And of course, everyone knows Dr. Glaucomflecken from his TikTok world and his other about 4 million followers on Instagram and Twitter and all these other social media, and YouTube. So welcome.Will Flanary (00:43):Thanks for having us.Kristin Flanary (00:44):Thank you. Happy to be here.By Way of BackgroundEric Topol (00:45):Yeah. Well, this is going to be fun because I'm going to go a quick background so we can go fast forward because we did an interview back in early 2022.Kristin Flanary (00:56):Yes.Eric Topol (00:57):And what you've been doing since then is rocking it. You're like a meteoric, right. And it was predictable, like rarefied talent and who couldn't love humor, medical humor, but by way of background, just for those who are not up to speed. I guess you got your start, Will, as a class clown when your mother was a teacher in the sixth grade.Will Flanary (01:22):Yep, yep. I misbehaved a little bit. It helped that I still made good grades, but I cut up a bit in class.Eric Topol (01:32):And then you were already in the comedy club circuits doing standup in Houston as an 18-year-old.Will Flanary (01:40):It was all amateur stuff, nothing, just dabble in it and trying to get better. I was always kind of naturally funny just with my friend group and everything. I loved making people laugh, but doing standups is a whole different ball game. And so, I started doing that around Houston as a high school senior and kept that going through college and a little bit into med school.Kristin Flanary (02:02):Houston was a good training ground, right? That where Harris Wittels was also coming up.Will Flanary (02:07):Yeah. A lot of famous comedians have come through Houston. Even going back to Bill Hicks back in the, was that the 80s, I think? Or 90s?Eric Topol (02:17):Well, and then of course, it was I think in 2020 when you launched Dr. Glaucomflecken, I think. Is that right?Will Flanary (02:28):That's when it really started to take off. I was on Twitter telling jokes back in 2016.Kristin Flanary (02:39):GomerBlog before that, that's actually where it was born.Will Flanary (02:41):I was doing satire writing. I basically do what I'm doing now, but in article form, trying to be The Onion of medicine. And then the pandemic hit, started doing video content and that's really with lockdown. That's when, because everybody was on social media, nobody had anything else to do. So it was right place, right time for me and branching out into video content.On to Medical School Commencement AddressesEric Topol (03:11):Alright, so that's the background of some incredible foundation for humor. But since we last got together, I'll link the Medicine and the Machine interview we did back then. What has been happening with you two is nothing short of incredible. I saw your graduation speeches, Will. Yale in 2022, I watched the UCSF in 2023 and then the University of Michigan in 2024. Maybe there's other ones I don't even know.Kristin Flanary (03:45):There's a few others.Will Flanary (03:45):There's a few. But I feel like you've done, I'm sure your fair share of commencement addresses as well. It's kind of hard to come up with different ways to be inspirational to the next generation. So fortunately, we have together, we have some life experiences and learned a thing or two by doing all of this social media stuff and just the things we've been through that I guess I have enough things to say to entertain an interest.Eric Topol (04:18):Well, you're being humble as usual, but having watched those commencement addresses, they were the best medical commencement addresses I've ever seen. And even though you might have told us some of the same jokes, they were so great that it was all right. Yeah, and you know what is great about it is you've got these, not the students, they all love you of course, because they're probably addicted to when's your next video going to get posted.(04:44):But even the old professors, all the family members, it's great. But one of the things I wanted to get at. Well, I'll start with the graduation speeches, because you were such an inspiration, not just with humor, but your message. And this gets back to you as a couple and the tragedies you've been through. So you really, I think, got into this co-survivor story and maybe Kristin, since you are the co-survivor of two bouts of Will's testicular cancer, and then the sudden cardiac death. I mean, people don't talk about this much, so maybe you could help enlighten us.Tragedies and Being a Co-SurvivorKristin Flanary (05:26):Yeah, it's funny because the experience of being a co-survivor is nothing new. It's as long as we've had human beings, we've had co-survivors. But the concept around it and giving it a name and a label, a framework to be able to think about it, that is what I think is new and what people haven't talked about before. So co-survivor is just this idea that when a medical trauma happens to a patient, the patient has their experience and if they survive it, they are a survivor and they have a survivor experience. And also, most people are closely attached to at least one other person, if not many. And those people are co-surviving the medical event along with the survivor. That event is happening in their lives as was happening to them too. If someone comes in with a patient to the hospital, that person, you can just assume by default that their lives are pretty intimately or profoundly intertwined or else why would that person be there? And so, thinking of it as there's the patient and then there's also a co-patient, that family members in the past have only been thought of as caregivers if they've been thought of at all. And that is certainly one aspect of the role, but it's important to remember that whatever it is that's happening to the patient is also affecting the family members' lives in a really deep and profound way.Eric Topol (07:04):That's really helpful. Now, the fact that you recognize that in your graduation speech, Will, I think is somewhat unique. And of course, some of the other things that you touched on like playing to your creativity and the human factors, I mean, these are so important messages.Will Flanary (07:23):Well, in the discussion about co-survivorship and because I talk about that whenever I do my keynotes and when I do the commencement addresses, but all credit goes to Kristin for really being the driving force of this idea for me and for many others because as a physician, we take care of patients. Our focus is always on the patient. And it really wasn't until this happened to me and my family and Kristin in particular that I started to understand exactly what she's talking about and this idea. And so, Kristin gets a lot of credit for just really bringing that term and that idea to the forefront.Eric Topol (08:09):Yeah, well, you saved his life. It's just not many have that bond. And then the other thing I just want to mention now, you've been recognized by the American Heart Association and a whole bunch of other organizations awarded because of your advocacy for CPR. And you even mentioned that I think in one of your commencement addresses.Will Flanary (08:31):Yeah, I tried to get the crowd to do CPR. Like team up, partner up, and it kind of fell flat. It wasn't quite the right time, I think, to try to do a mass class on CPR. So maybe next time.Eric Topol (08:47):Right. Well, so you had this foundation with the Glaucomflecken General Hospital and taking on 37 specialties and all these incredible people that became part of the family, if you will, of spoof on medicine and your alter ego and these videos that you would do. And sometimes you have three or four different alter egos in there playing out, but now you've branched into new things. So one which is an outgrowth of what we were just talking about. You've been on this country tour, Wife & Death.“Wife and Death,” A Nationwide TourKristin Flanary (09:28):Yes.Eric Topol (09:29):Wife and death. I mean, yeah, I guess we can make the connect of how you named it that, but what is it you've been selling out in cities all over the country, and by the way, I'm really upset you haven't come to San Diego, but tell us about wife and death.Will Flanary (09:44):Yeah. Well, we have this amazing story and all these medical challenges we've been through, and then developing the Glaucomflecken brand and universe, and we've done keynotes together for years, and then we thought, let's have more fun with it. Let's do keynotes. They're great. We can get our message out, but sometimes they're just a bit stuffy. It's an academic environment.Kristin Flanary (10:15):They're usually at seven in the morning also, so that's the downside.Will Flanary (10:21):So we thought, let's just put together our own live show. Let's put together something that we could just creatively, we can do whatever we want with it. I could dress up as characters, Kristin, who has these beautiful writing and monologues that she's put together around her experience and just to create something that people can come into a theater and just experience this wide range of emotions from just laughter to tears of all kinds, and just have them feel the story and enjoy this story. Fortunately, it has a happy ending because I'm still alive and it's been so much fun. The audiences have been incredible. Mostly healthcare, but even some non-healthcare people show up, and we've been blown away by the response. Honestly, we should have done bigger theaters. That's our lesson for the first go round.Eric Topol (11:21):I saw you had to do a second show in Pittsburgh.Will Flanary (11:24):We did.Kristin Flanary (11:26):That one sold out too. Something about Pittsburgh, that was a good crowd, and there was a lot of them.Will Flanary (11:33):It was almost like in Pittsburgh, they rarely ever get any internet comedian ophthalmologists that come through. I don't know.Eric Topol (11:41):Well, I see you got some still to come in Denver and Chicago. This is amazing. And I wondered who was coming and I mean, it's not at all surprising that there'd be this phenomenal popularity. So that's one thing you've done that's new, which is amazing. And of course, it's a multidimensional story. The one that shocked me, I have to tell you, shocked me, was the New England Journal partnership. The New England Journal is the most stodgy, arrogant, I mean so difficult. And not only that.Kristin Flanary (12:17):You said that. Not us.Partnering with the New England Journal of Medicine!Eric Topol (12:19):Yeah, yeah. They'll get this too. They know we don't get along that well, but that's okay. You even made fun of journals. And now you're partnering with the New England Journal, God's greatest medical journal, or whatever. Tell us about that.Will Flanary (12:39):Well, so one thing that I really enjoy doing, and I've done it with my US healthcare system content is almost like tricking people into learning things. And so, if you make something funny, then people will actually sit there and listen to what you have to say about deductibles and physician-owned hospitals and all these inner workings. DIR fees and pharmacy, all these things that are really dry topics. But if you can make them funny, all of a sudden people will actually learn and listen to it. And the New England Journal of Medicine, they approached me with an idea. Basically just to take one or two of their trials per month. And I just make a skit out of that trial with the idea being to help disseminate some of the research findings that are out there, because I guess it's getting harder and harder for people to actually read, to sit down and read a journal article.(13:43):And so, I have to credit them for having this idea and thinking outside the box of a different way to get medical information and knowledge out to the masses. And you're absolutely right, that I have been critical of journals, and particularly I've been critical of the predatory nature of some of the larger journals out there, like Elsevier. I've specifically named Elsevier, Springer, these journals that have a 40% profit margin. And I certainly thought about that whenever I was looking into this partnership. And the reason I was okay with doing it with the New England Journal is because they're a nonprofit, first of all, so they're run by the Massachusetts Medical Society. That's the publisher for that journal. And so, I feel okay partnering with them because I feel like they're doing it in a much better way than some of the bigger journal corporations out there.Kristin Flanary (14:54):Well, and also part of the deal that we negotiated was that those articles that you make skits about those will be available open access.Will Flanary (15:03):Oh yeah. That was a prerequisite. Yes. It was like, if I'm going to do this, the articles that I'm talking about need to be free and readily available. That's part of it.Eric Topol (15:14):I think you've done about five already, something like that. And I watched them, and I just was blown away. I mean, the one that got me where I was just rolling on the floor, this one, the Belantamab Mafodotin for Multiple Myeloma. And when you were going on about the Bortezomib, Dexamethasone. We'll link to this. I said, oh my God.Will Flanary (15:40):Yeah. The joke there is, you don't have any idea how long it took me to say those things that quickly. And so, I was writing this skit and I'm like, wouldn't it be funny if somehow that triggered a code stroke in the hospital because this person is saying all these random words that don't have any meaning to anybody. Man, I tell you, I am learning. Why would I ever need to know any of this information as an ophthalmologist? So it's great. I know all this random stuff about multiple myeloma that I probably would never have learned otherwise.Kristin Flanary (16:21):It's the only way, you won't read a journal either.Eric Topol (16:23):Well, and if you read the comments on the post. These doctors saying, this is the only way they want to get journal information from now on.Will Flanary (16:33):Which is double-edged sword, maybe a little bit. Obviously, in a 90 second skit, there's no way I'm going to cover the ins and outs of a major trial. So it's really, in a lot of ways, it's basically like, I call it a comedy abstract. I'm not going much further than an abstract, but hopefully people that are actually interested in the topic can have their interest piqued and want to read more about it. That's kind of the idea.Eric Topol (17:06):Yeah. Well, they're phenomenal. We'll link to them. People will enjoy them. I know, because I sure did. And tenecteplase for stroke and all that you've done. Oh, they're just phenomenal.Will Flanary (17:20):Every two weeks we come out with a new one.Eric Topol (17:24):And that is basically between the fact that you are now on the commencement circuit of the top medical schools and doing New England Journal videos on their articles. You've crossed a line from just making fun of insurance companies and doctors of specialties.Kristin Flanary (17:44):Oh, he has crossed many lines, Dr. Topol.Eric Topol (17:46):Yeah. Oh yeah. Now you've done it, really. Back two years ago when we convened, actually it's almost three, but you said, when's it going to be your Netflix special?Will Flanary (18:02):Oh, gosh.Eric Topol (18:02):Is that in the works now?Will Flanary (18:04):Well, I'll tell you what's in the works now.Kristin Flanary (18:06):Do you know anyone at Netflix?Will Flanary (18:09):A New Animated SeriesNo. We're working on an animated series.Eric Topol (18:12):Oh, wow. Wow.Will Flanary (18:13):Yeah. All these characters. It's basically just this fictional hospital and all these characters are very cartoonish, the emergency physician that wears the bike helmet and everything. So it's like, well, what do we have together? What do we, Kristin and I have time for? And it wasn't like moving to LA and trying to make a live action with actors and do all, which is something we probably could have tried to do. So instead, we were like, let's just do an animated series.Kristin Flanary (18:48):Let's have someone else do the work and draw us.Will Flanary (18:51):So we've worked with a writer for the first time, which was a fun process, and putting together a few scripts and then also an animator. We learned a lot about that process. Kristin and I are doing the voiceovers. And yeah, it's in process.Kristin Flanary (19:10):We're the only actors we could afford.Will Flanary (19:12):Right, exactly.Eric Topol (19:13):I can't wait to see it. Now when will it get out there?Will Flanary (19:17):Well, we're hoping to be able to put it out on our YouTube channel sometime early next year. So January, February, somewhere around there. And then we can't fund the whole thing ourselves. So the idea is that we do this, we do this pilot episode, and then we'll see what kind of interest we can generate.Eric Topol (19:37):Well, there will be interest. I am absolutely assured of that. Wow.Will Flanary (19:42):Let us know if you know anybody at the Cartoon Network.Kristin and Will Flanary (19:45):Yeah, we're open to possibilities. Whatever, Discovery channel. I don't know.Eric Topol (19:51):You've gotten to a point now where you're ready for bigger things even because you're the funniest physician couple in medicine today.Kristin Flanary (20:05):Well, that's a very low bar, but thank you.Will Flanary (20:08):There are some funny ones out there, but yeah, I appreciate that.Eric Topol (20:11):Well, I'm a really big comedy fan. Every night I watch the night before, since I'm old now, but of Colbert and Jimmy Kimmel, just to hear the monologues. Trevor Noah, too. And I can appreciate humor. I'll go to see Sebastian Maniscalco or Jim Gaffigan. That's one of the things I was going to ask you about, because when you do these videos, you don't have an audience.Will Flanary (20:39):Oh yeah.Eric Topol (20:40):You're making it as opposed to when you are doing your live shows, commencement addresses and things like that. What's the difference when you're trying to be humorous, and you have no audience there?Will Flanary (20:55):Well, whenever I'm filming a skit, it's just all production. In fact, I feel like it's funny. I think it's funny, but it's really not until I see the response to it, or I show Kristin, or what I have is where I really know if it's going to work. It's great to put the content out there and see the responses, but there's nothing like live interaction. And that's why I keep coming back to performing. And Kristin's been a performer too in her life. And I think we both really enjoy just the personal interaction, the close interaction, the response from people to our story.Kristin Flanary (21:36):We do most of our work alone in this room. I do a lot of writing. He does a lot of playing.Will Flanary (21:44):Dress up.Kristin Flanary (21:44):All the people in his head, and we do that very isolated. And so, it's very lovely to be able to actually put names to faces or just see human bodies instead of just comments on YouTube.Will Flanary (21:59):Meet people.Kristin Flanary (21:59):It's really nice.Will Flanary (22:01):We've been doing meet and greets at the live shows and seeing people come up wearing their costumes.Eric Topol (22:07):Oh, wow.Will Flanary (22:11):Some of them talk about how they tell us their own stories about their own healthcare and talk about how the videos help them get through certain parts of the pandemic or a difficult time in their life. And so, it reinforces that this means something to a lot of people.Kristin Flanary (22:29):It's been really fun for me, and probably you too, but to get to see the joy that he has brought so many people. That's really fun to see in person especially.Eric Topol (22:42):No question. Now, when you're producing it together, do you ever just start breaking into laughter because it's you know how funny this is? Or is it just you're on kind of a mission to get it done?Will Flanary (22:54):Well, the skits I do by myself. And sometimes when I'm writing out the skit, when I'm writing the skit itself, I will laugh at myself sometimes. Not often, but sometimes they're like, oh, I know that's really funny. I just wrote a skit that I'm actually going to be debuting. I'm speaking at the American Academy of PM&R, so the big PM&R conference. I'm writing a skit, it's How to Ace your PM&R residency interview.Will Flanary (23:28):I was writing up that skit today and kind of chuckling to myself. So sometimes that happens, but whenever we do our podcast together, we definitely have outtakes.Kristin Flanary (23:38):Oh yeah, we've got some.Will Flanary (23:40):We crack each other up.Kristin Flanary (23:41):We do.Will Flanary (23:42):Sometimes we're getting a little punchy toward the end of the day.Eric Topol (23:47):And how is the Knock Knock, Hi! podcast going?Will Flanary (23:51):It's awesome. Yeah.Kristin Flanary (23:52):Yeah. It's a really fun project.Will Flanary (23:54):We still enjoy. You can work with your spouse and in close proximity and still be happily married. So it's doable everyone.Kristin Flanary (24:06):That's right. And we're in that phase of life that's really busy. We've got kids, we've got a gazillion jobs. House, my parents are around, and so it's like the only time all week that we actually get to sit down and talk to each other. So it's actually kind of like a part of our marriage at this point.Will Flanary (24:28):We're happy to involve the public in our conversations, but we couldn't do it because we have all these things going on, all our hands and all these little places. We can't do it without a team.Kristin Flanary (24:41):Yeah, absolutely.Will Flanary (24:41):And that's the thing that I've learned, because I've always been a very loner type content creator. I just wanted to do it all myself. It's in my head and I have trouble telling others, describing what's in my head. And Kristin and our producers have helped me to be able to give a little bit of control to others who are really good at what they do. And that's really the only way that we've been able to venture out into all these different things we've talked about.Eric Topol (25:12):Well, I think it comes down to, besides your ability to get to people in terms of their laughter receptors, you have this incisive observer capability. And that's one of the things I don't, I can't fathom because when you can understand the nuances of each specialty or of each part of healthcare, and you haven't necessarily interacted with these specialists or at least in recent years, but you nail it every time. I don't know how you do it, really that observational, is that a central quality of a comedian, you think?Will Flanary (25:52):There's definitely a big part of that. You got to get the content from somewhere. But for the specialties, it's really first about just getting the personalities down. And that doesn't change over time.Kristin Flanary (26:08):Or around the world.Will Flanary (26:09):Or around the world. We hear from people from all over the world about, oh, it's the same in Guatemala as it is in the US.Kristin Flanary (26:18):Surgeons are the same.Will Flanary (26:19):Yeah.Kristin Flanary (26:20):Emergency is the same.Will Flanary (26:21):Which has been really cool to see. But so, I draw on my experience interacting with all these specialties back in my med school and intern days. You're right, as an ophthalmologist, we don't get out very much.Eric Topol (26:33):No.Will Flanary (26:35):So very few people have ever seen an ophthalmologist. We do exist. But then beyond that, I do have to include some actual medical things. And so, I actually, I do a lot of research. I find myself learning more about other fields sometimes than I do in my own field. So especially the further out I get from med school, I know less and less.Eric Topol (27:00):Yeah, that's what I was thinking. But you're always spot on. It's interesting to get that global perspective from both of you. Now you're still doing surgery and practicing ophthalmology. Have you reduced it because this has just been taking off so much more over the recent years or keeping it the same?Will and Kristin Flanary (27:21):Nope, I'm still. Do you know how many years I had to come along on all of this medical training? He is not allowed to give this up.Will Flanary (27:29):I know there's something called a sunk cost fallacy, but this is no fallacy. There's enough of a sunk cost. I got to stick with it. No, I still enjoy it. That's the thing. It actually, it informs my comedy, it grounds me. All of the social media stuff is built upon this medical foundation that I have. And if I stopped practicing, I guess I could maybe cut back. But I'm not planning on doing that. If I stop practicing medicine, I feel like it would make my content less.Kristin Flanary (28:07):Authentic.Will Flanary (28:08):Less authentic, yeah. That's a good way to put it.Eric Topol (28:09):Yeah, no, that makes a lot of sense. That's great you can get that balance with all the things you're doing.Will Flanary (28:17):And if I stop practicing medicine, they're not going to invite me to any more commencement addresses, Dr. Topol. So I got to draw the line somewhere.Eric Topol (28:28):One of the statements you made at some point earlier was, it was easier to go to become a doctor than to try to be a comedian. And yeah, I mean you proven that.Will Flanary (28:38):A lot of ways. That's true.Eric Topol (28:40):Wow. I am pretty awestruck about the rarefied talent that you bring and what you both have done for medicine today. And the thing is, you're so young, you have so much time ahead to have an impact.Will Flanary (28:57):You hear that Kristin, we're young. Look at that.Kristin Flanary (29:00):That's getting less and less true.Will Flanary (29:01):Kristin, she just turned 40. It's right around the corner for me. So I don't know.Will Flanary (29:11):We got some years left.Eric Topol (29:12):You're like young puppies. Are you kidding? You're just getting started. But no, I think that what you brought to medicine in terms of comedy, there's no other entity, no person or people like you have done. And just the last thing I want to ask you about is, you have a platform for advocacy. You've been doing that. We talked about co-survivor. We talked about nurturing the human qualities in physicians like creativity and also taking on the insurance companies, which are just monstrous. I'll link a couple of those, but the brain MRI one or the Texaco.Will Flanary (29:54):Texaco Mike.Eric Topol (29:55):Yeah, that one is amazing. But there is so many. I mean, you've just taken them apart and they deserve every bit of it. Do you have any other targets for advocacy or does that just kind of come up as things go?Will Flanary (30:08):It kind of comes up as things go. There's things I keep harping on. The prior authorization reform, which I've helped in a couple of different states. There's a lot of good people around the country doing really good work on prior authorization and reforming that whole process. And I've been able to just play a small part in that in a couple of different ways. And it's been really fun to do that. And so, I do plan on continuing that crusade as it were. There's certain things I'd like to see. I've been learning more about what pharmacists are dealing with as well as a physician. Unfortunately, we are very separate in a lot of ways and just how we come up in medicine. And so, I have had my eyes opened a lot to what community pharmacists are dealing with. For all the terrible things that we have to deal with as physicians in the healthcare system. Pharmacists have just as much, if not more of the things that they're doing that are threatening their livelihoods. And so, I had love to see some more reform on the PBM side of things, pharmacy benefit managers, Caremark, Optum, all of them. They're causing lots of problems.Eric Topol (31:24):I couldn't agree with you more. In fact, I'm going to have Mark Cuban on in a few weeks and we're going to get into that. But the pharmacists get abused by these chains.Will Flanary (31:33):Oh, it's bad. It's really bad.Eric Topol (31:35):Horrible, horrible. I feel, and every time I am in a drugstore working with one of them, I just think what a tough life they have to deal with.Will Flanary (31:45):I guess from an advocacy standpoint, the good news is that there's never a shortage of terrible injustices that are being foisted upon the public and physicians and healthcare workers.Kristin Flanary (31:59):Yes. The US healthcare system is ripe for advocacy.Will Flanary (32:01):Yes. And that's a lesson that I tell people too, and especially the med students coming up, is like, there's work to be done and get in touch with your state societies and there's always work to be done.Eric Topol (32:18):Now you've stayed clear of politics. Totally clear, right?Will Flanary (32:24):For the most part, yeah. Yeah. It depends on what you consider politics. It depends on what you consider politics.Eric Topol (32:32):It being election day, you haven't made any endorsements.Will Flanary (32:36):I haven't. And I don't know. I can only handle so much. I've got my things that I really care about. Of course I'm voting, but I want to talk on the things that I feel like I have the expertise to talk about. And I think there's nothing wrong with that. Everybody can't have an opinion on everything, and it means something. So I am happy to discuss the things that I have expertise about, and I'm always on the side of the patient and wanting to make life better for our patients. And that's the side I'm on.Kristin Flanary (33:25):I think also he never comes out and explicitly touches on certain topics, but it's not hard to tell where he falls.Will Flanary (33:34):If you really want read into it all.Kristin Flanary (33:38):It's not like it's a big secret.Eric Topol (33:40):I thought that too. I'm glad you mentioned it, Kristin. But it doesn't come out wide open. But yeah, it's inferred for sure.Eric Topol (33:49):I think the point being there is that because you have a reach, I think there's no reach that it has 4 million plus people by your posts and no less the tours and keynotes and everything else. So you could go anywhere but sticking to where you're well grounded, it makes a lot of sense. And anyway, I am going to be staying tuned. This is our two-year checkup. I'm hoping you're going to come to San Diego on your next tour.Kristin Flanary (34:21):We're working on 2025 plans.Will Flanary (34:23):Oh, we got more shows coming up. And we'll hit up other parts of the country too.Eric Topol (34:28):I feel like I got to meet you in person, give you a hug or something. I just feel like I'm missing out there. But it's just a joy to have had a chance to work with you on your podcast. And thanks for coming back on one of mine. There's lots of podcasts out there, but having you and joining you is such fun. So thank you.Will Flanary (34:54):This has been great. Thank you for having us.Kristin Flanary (34:55):Yeah, thank you.*****************************************Thank you for reading, listening and and subscribing to Ground Truths.If you found this fun and informative please share it! Yes, laughter is the best medicine.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.Note on Exodus from X/twitter:Many of you have abandoned the X platform for reasons that I understand. While I intend to continue to post there because of its reach to the biomedical community, I will post anything material here in the Notes section of Ground Truths on a daily basis and cover important topics in the newsletter/analyses. Get full access to Ground Truths at erictopol.substack.com/subscribe

Episode 11: “By Way of Conclusion”Unit 15: “John of the Ladder: Principles of the Christian Life”, by Prof. Christopher VeniaminSeries: “Mystical Theology"“By Way of Conclusion”, Episode 11 in our series, "John of the Ladder”, consists of concluding remarks regarding our brief overview of Steps 4 and 5 of the famous Ladder of Divine Ascent by the great John Climacus. Presented by Dr. Christopher Veniamin, themes from this episode are listed in the Timestamps below.Q&As available in The Professor's Blog: https://mountthabor.com/blogs/the-professors-blogRecommended background reading: The Ladder of Divine Ascent (Holy Transfiguration Monastery); Saint Silouan the Athonite, by St. Sophrony the Athonite (https://mountthabor.com/products/st-silouan-the-athonite); and The Enlargement of the Heart, by Archimandrite Zacharias (https://mountthabor.com/products/the-enlargement-of-the-heart-2nd-ed)Support the showDr. Christopher VeniaminSupport The Mount Thabor Academyhttps://www.buzzsprout.com/2232462/support The Professor's BlogFurther bibliography may be found in our Scholar's Corner.THE MOUNT THABOR ACADEMYPrint Books by MOUNT THABOR PUBLISHING eBooks Amazon Google Apple KoboB&NMembershipsJoin our Academy on Patreon: Membership TiersYouTube Membership LevelsContact us: ...

Superimposed on an impressive body of work on the blood-brain-barrier and immune system, Prof Akassoglou and her collaborators just published an elegant study in Nature that centered on the direct binding os the SARS-CoV-2 spike protein to fibrin with marked downstream pro-inflammatory effects. The findings and potential treatments have implications beyond Covid, Long Covid to other neurologic diseases.Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with links to audio and to relevant papers, graphicsEric Topol (00:07):Well, hello this is Eric Topol with Ground Truths, and with me today is Katerina Akassoglou. She is at the Gladstone Institute and she is a remarkable neuroimmunologist who has been doing extraordinary work for three decades to unravel the interactions between the brain, blood vessels and the role of inflammation. So Katerina, there's a lot to discuss, so welcome.Katerina Akassoglou (00:40):Thank you. Thank you so much. It's a great pleasure to join.By Way of BackgroundEric Topol (00:43):It's really interesting going back in your career. First of all, we're thankful that you immigrated here from Greece, and you have become one of the leading scientists in this discipline of important discipline of neuroimmunology, which is not just about Covid that we're going to talk about, but Alzheimer's and neurodegenerative diseases. This is a really big hot area and you're definitely one of the leaders. And what I was impressed is that all these years that you've been working on the integrity of the blood-brain barrier, the importance of fibrinogen and fibrin, and then comes along the Covid story. So maybe what we can do is start with that, which is you've made your mark in understanding this whole interaction between what can get into the brain, through the blood-brain barrier and incite inflammation. So this has been something that you've really taken to the extreme knowledge base. So maybe we can start with your work there before we get into the important seminal Nature paper that you recently published.Katerina Akassoglou (01:57):Yes, of course. So since very early on, I was still a graduate student when we made the first discovery and at the time was like mid-90s, so it was really ahead of its time. That dysregulation of cytokine expression in the brain of mice was sufficient to induce the whole cascade of events, triggering neurodegeneration, demyelination in pathological alterations, very reminiscent of multiple sclerosis pathology. And it was really hard to publish that study at the time because it was not yet accepted that this regulation of the immune system modeling the brain can be linked to neurodegeneration. So that was 1995 when we made that discovery, and I became really interested, what are the pathogenic triggers that actually polarized the immune cells in the brain? So with this, of course, this transgenic animal was expressing TNF, it was an artificially made animal that we made, but naturally what were the triggers that would polarize the innate immune cells? So I looked really early on in this mice and what I found was that the very first event was leaks of blood-brain barrier. It was opening of the blood-brain barrier in this mouse before inflammation, before demyelination, before neuronal loss. And this is really what shaped the question that, is it possible that these blood leaks that happened very early in the pathology, could this be the instigators of pathogenic inflammation in the brain?Eric Topol (03:34):Yeah. So in a way, you got at this question because of the chicken-and-egg and what happens first, and you got to the temporal saying, which happened first as you said, the leak before you could see evidence of inflammation and being able to study this of course in the experimental model, which you couldn't really do in people. And what I love about the description of your career, which has been quite extraordinary contributions is connecting the dots between the blood, the inflammatory response and the brain. Perhaps no one has done that like you have. And before we get into the recent paper, a lot of people are not aware that a year ago, a group in the UK known as PHOSP-COVID, they published a really important paper in Nature Medicine of over 1,800 people who were hospitalized with Covid and they found that fibrinogen was the best marker for cognitive deficits at 6 and 12 months (Figure below)(04:40):So that's just one of many papers, but it's a particularly well done study that already before you got into this work that recently published had emphasized fibrinogen. And by the way, again, having spent a lot of years in clots in the arteries, for me, we have to just get it down to fibrinogen plus thrombin gets you to fibrin. Okay, so fibrin is a major player here when fibrinogen is cleaved. So here we have the basis that you established, which is the fibrinogen leakage into the brain, activating inflammation, activating microglia, which like the macrophages of the brain and inciting the whole process. And before we close, I want to not just talk about Covid, but Alzheimer's too. But now let's get into the study that you did, [Fibrin drives thromboinflammation and neuropathology in COVID-19] which is striking, I mean really striking. And can you kind of take us through, because you not only demonstrated the importance of fibrin in inciting neuroinflammation in this model, but also how you could reverse it or prevent it. So this, and you looked at it in many different ways, this was a systematic approach. Maybe you can take us through how you were able to make such compelling evidence.The Multimodal EvidenceKaterina Akassoglou (06:09):Yes, thank you. First of all, thank you for bringing up the human relevance because this was also our inspiration for the work that we did in the Covid study. So as you mentioned in Covid patients, fibrinogen unbiased mass spec analysis was identified as the predictive biomarker for cognitive impairment in Long Covid patients. And this was in addition to also neuropathology data about the abundance of fibrin deposition in the brain. And these were studies that were done by NIH that have found deposition of fibrin in the brain and the reports for the abnormal and puzzling coagulation in Covid that is not setting other infections and also in many cases not always relating with the severity of symptoms. So even mild cases of Covid also had increased coagulation. I was really intrigued by this human, all this evidence in human data, and I thought that maybe the way that we're thinking about this, that it's systemic inflammation that drives the clotting.(07:24):Maybe there's another aspect to this. Maybe there is a direct effect of the virus with the coagulation cascade, and in this way maybe this can be an instigator of inflammation. So this was the original idea to be able to reconcile this data from the clinic about why do we have this prevalence of coagulopathy in Covid. And of course, the second question is, could this also be a driver of the disease? And of course, we're in a unique position because we have been studying this pathway now for over 20 years to have all the toolbox, the genetic toolbox, the pharmacologic toolbox to be able to actually really address these questions with genetic loss of function studies, with a blood innate immunity multiomics pipeline that we have set up in the lab. And of course, with preclinical pharmacology in our ABSL3 facility. So we had the infrastructure in place and the source in place to actually really dissect this question with both genetic tools as well as also technology platforms.Eric Topol (08:29):And you had in vivo imaging, you're the director of in vivo imaging for Gladstone and UCSF. So you do have the tools to do this.Katerina Akassoglou (08:38):Yes. The imaging that you mentioned is really important because this is, we employed that very early in our studies over now 15 years ago. And the reason was sometimes from snapshots of histopathology, you cannot really understand the sequence of events. So by being able to image these processes, both neuronal activity, microglia activation, infiltration of peripheral cells in the brain, this is how we could see the steps that what happens early on and to be able to answer these chicken-and-egg questions that you mentioned. So these were very, they're very important experiments, especially at the beginning because they were hypothesis driving and we were able to ask the right questions to drive our research program.Eric Topol (09:26):Now was the binding of the spike protein to one key site in fibrinogen, was that known before? [See outstanding Figure below from Trends in Immunology]Katerina Akassoglou (09:36):No, this was not known. So there was evidence that there are abnormal clots in Covid, but it was not known whether the spike protein would directly bind to protein to the coagulation cascade. So one of the key discoveries in our study was to use peptide array mapping and be able to identify not only the binding, but exactly the domains on fibrin that spike binds too. And what we found was two key domains, one the inflammatory domain and the other the plasmin binding site, which is important for fibrin degradation. So this suggested a potential dual deleterious role for this interaction, both by maybe affecting inflammation, but also delaying fibrinolysis, which is the degradation of this toxic protein from the brain. And indeed, we found that this interaction was responsible for all these two aspects, including decreased degradation, more inflammation, but also at the same time increased, increased coagulation. So it was a really pathogenic interaction.Eric Topol (10:47):Yeah, actually it's pretty striking. You have these two sites, the plasmin cleavage site of fibrinogen, which as you say, we knew there was a problem with clots. We knew that, but we didn't know exactly the spike protein how exactly it was implicated, particularly with fibrinogen. And then this other site, the CD11b-C18, now that's fancy for surface receptors of macrophages. And basically, this is critical because it's this microglia activation in the brain, and I know you saw it in the lungs as well through this other site that spike protein activated. So you had a twofer here of things that you discovered that the SARS-CoV-2 spike protein was capable of doing. This was a really big revelation. And then you also looked at mice that were genetically manipulated. So maybe you can, because before we get to your antibody monoclonal, the ways that you proved this were, I mean, one thing after another is really systematic. So maybe you can teach us about that.Thanks for reading Ground Truths! This post is public so feel free to share it.Establishing CausalityKaterina Akassoglou (12:08):Yeah, sure. So the first was about chemistry experiment. So this of course, we had to get to the next step to see is there any causality for this pathway. So we employed genetic loss of function studies and we had knockout mice, either fibrinogen knockout mice, this mice have all blood proteins except fibrinogen, and they have a delay in coagulation so they don't clot properly. But we also had a mutant mouse, which is a fibrinogen NK mouse. And this was a mutation only within this inflammatory domain that you mentioned, inflammatory domain that binds to C11b-C18. Other names for this is of course complement receptor 3, Mac-1 (αMβ2). It's the same, many names for this receptor, that as you mentioned, is expressed not only in microglial in the brain, but also peripheral immune cells including macrophages as well as also neutrophils which are CD11b expressing.(13:12):So we now have genetic models to be able to look at both complete depletion of fibrinogen, but also a very specific mutation and very selective mutation that only blocks the inflammatory properties without affecting the properties of fibrin in hemostasis. And these mice were made many years ago by a very close collaborator, Jay Degen at the University of Cincinnati. So what we found is that when we block either the inflammatory domain or we completely deplete fibrinogen, there was this profound protection after infection in internasal infection with the virus in lung inflammation. And this was both suppression of oxidative stress and this pathogenic inflammation in the lung, but also decreasing fibrosis, which has been associated with also Long Covid. And the surprise came from the transcriptomic data. So when we did transcriptomic analysis in this mice in the lungs, we found perhaps the expected decrease in the immune signatures in macrophages. This was in line with our previous work in, as you mentioned, Alzheimer's models, multiple sclerosis models. But what also was really surprising is there was that genes that are associated with activation of NK cells were upregulated. And of course this was the first time we had infected these mice, previously we had not done an infection before. So I think that maybe because of this region we had not seen before in our data this immunomodulatory role of fibrin that not only surprises the macrophage response, but also increases these NK cells that are important for viral clearance.Eric Topol (15:00):So again, the finding another important unique finding is the natural killer (NK) cells and effect there from the activation of this, as you said, the inflammation site or the CD11b-C18 that we've been talking about. So now another layer of this, a dimension of your Nature paper was that you tested an antibody that you already had developed so-called 5B8. A monoclonal that specifically binds to the domain of the one we're talking about this inflammation domain of fibrinogen. So can you tell us about what that showed?Katerina Akassoglou (15:45):Yes, so we tested this antibody in different models of Covid, which were both models with neuroinvasion and models without neuroinvasion. So we used both transgenic mice for hACE2, the human ACE2 infected with Delta, but we also use mouse adapted viruses like Beta that is just in the wild type mice with no transgenic being involved that these are without neuroinvasion. And we wanted to see if the antibody had any potential protective effects. And what we found is that the antibody protected from inflammation in the lung. So the data looked so similar with a genetic mutation of this pathway, protection from inflammation, decreased fibrosis, increased viral clearance, so decreased spike and viral proteins in the lungs. But we also found a protection in the brain. So the brains of this mice, including both the models we used with neuroinvasion and without, they both have had microglia activation in the brain. And we also found neuronal loss in the Delta infected mice and the antibody protected from both neuroinflammation but also improved neuronal survival in the mice. Showing that there can be this despite regardless of which model we used, there was this protective effect suggesting that by blocking fibrin, either the periphery or in the brain, this could be protected for these models.Eric Topol (17:28):Yeah, so I mean this is fascinating because until now, until this report of yours and your colleagues at Gladstone, there was knowledge that there would be neuroinflammation from Covid, both in patients from various biomarkers and imaging as well as in experimental model. But what this did was take it to the fibrin story, and I guess that's one of the questions you nailed that how important fibrin is, but that doesn't necessarily rule out other triggers of neuroinflammation, right?Katerina Akassoglou (18:04):Oh, absolutely not. So I think that this is one of the mechanisms that can be very important, especially in some patients. But we know that there are additional of course mechanisms of neuroinflammation including auto-antibody responses, as well as also endotheliopathy that are persistent endotheliopathy, this can be interacting also with each other. So I think that it's important for future research that we understand how do these mechanisms feed into each other? Are there a positive feedback loops between autoimmune mechanisms and coagulopathy and endothelial dysfunction with inflammation? But I think most importantly, I think that if we're thinking of this in the context of patients, can we identify patients with mechanism that might be more prevalent in specific cases of Long Covid and tailor our potential future clinical trials towards the needs of Long Covid patients?Towards TreatmentEric Topol (19:06):Absolutely. I did interview some months back on Grounds Truths, Michelle Monje at Stanford, who I'm sure and interact with, and she's also works not so much on the fibrin side, but on neuroinflammation and the likeness between this condition in people and chemo brain because of the inflammation that's seen there. So we've talked about the multiple triggers that could contribute to brain inflammation, which I think most people would say in Long Covid this is one of the most, besides obviously the lack of energy, the profound fatigue and disability, but the cognitive function hit, not just brain fog is often profound. And we've just seen some reports about that, and particularly in hospitalized patients, how bad that can be. So that gets us to a potential treatment. Now, one of the things that's out there dangling, there's many things that people have talked about in terms of why can't we have a treatment for Long Covid?(20:13):And now of course this fibrin pathway, if you will, lends itself to many possibilities, whether it's anticoagulants or fibrinolytics like a tPA or things like nattokinase, which is a Japanese food enzyme that you could get at the nutrition centers or whatever. What are your thoughts? Because we don't have any good studies. There are all these little, tiny studies and they don't provide much conclusion, and you have an antibody that could potentially be effective. As I understand it, you set up a company some years ago, Therini Bio and used to be called MedaRed. You're the first woman scientist at Gladstone to develop a spin out company, which is another point of congratulations on that. But could the antibody be tested in patients or what do you think about these other possibilities?Katerina Akassoglou (21:15):Yes, yes. These are great questions. So first of all, the different approaches that you mentioned have very different mechanism of action. So degrading fibrin, the degradation products of fibrin also can have deleterious effects. The dimer, for example, can be very pro-inflammatory. So at the same time, blocking coagulation can also have a diverse effects because this can lead to excessive hemorrhage. So the approach that we took was to selectively block the inflammatory properties of fibrin without affecting beneficial effects of the molecule in normal hemostasis. So the challenge when I made the antibody was to be able to dissect these two functions of fibrin. It's our most important clotting factor, but at the same time, a molecule with profound pro-inflammatory capacity. So the observation that these two domains, the clotting domain and inflammatory domain were not overlapping, was really the foundation of this invention was that we could maybe create this antibody to be able to target them in a selective way.Other Neurologic Conditions (22:31):So the antibody I developed is neutralizing blood toxicity by blocking the inflammatory domain of fibrin without adverse coagulation effects. And it's now completing phase one trials. So it has already completed the single ascending dose at 40 milligram per kilogram. It's interim data were announced already for this trial, with no safety signals. So if the antibody completes this year, the phase one trials, then it should be possible to be tested in different patient populations. You mentioned before chemo brain, and I think it's important that we think that blood-brain barrier disruption occurs among many neurological conditions, and it's an early event associated with early disease onset and worse prognosis in multiple sclerosis, Alzheimer's disease, traumatic injuries. So I think that it's by developing a strategy, therapeutic strategy to neutralize blood toxicity, this can have applications in a wide range of neurological conditions with vascular dysfunction.Eric Topol (23:54):Yeah, no. In your Nature Immunology 2020 piece [Figure below], you started with the 1883 identification of multiple sclerosis (MS) lesions were “engorged with blood”, the first link between blood leaks and brain inflammation. So this has enormous potential. And what I like about this Katerina is that you've dissected the clot component versus the inflammatory trigger of the fibrinogen and fibrin story. And this is so vital because if you keep throwing these things that just going to work on the clot and not deal with the pro-inflammatory consequences, then you're going to get the wrong impression that clots are not that important. And by the way, you did mention, and I want to come back to that too, endothelial inflammation, which is another feature of Long Covid is another kind of interactive part of this because when the lining of the blood vessel is inflamed, it will attract microthrombi and also be a participant in this whole affair. What do you think about Alzheimer's and the prospects of being able to interfere with Alzheimer's? We have 20 years in someone before this process takes hold and meets clinical manifestations. Would an antibody like this ever be useful along the way?Katerina Akassoglou (25:29):Yeah, so well, our antibody was tested first in Alzheimer's, this models when it was originally published, and we performed reversal trials in Alzheimer's models. So we dosed mice when they have established amyloid plaques, microglia activation, neuronal loss, and we could reverse this effect so it could increase cholinergic neurons in mice, reduce inflammation in a very selective way, only the neurotoxic part of inflammation and for genetic depletion of this pathway with akin mice in Alzheimer's disease. Also, improves from cognitive impairment, and we now have a new paper in Cell Press that is showing this effects also with really nice and unbiased machine learning models for behavioral segmentation [Figure below].So I think that there is the data both from genetic studies and the antibody show projection in Alzheimer's disease. And of course, as you might have read the recent Lancet report from the Lancet committee on dementia that identified the vascular risk factors as the key contributors, especially post sporadic cases of Alzheimer's disease that is over 90% of Alzheimer's disease that is not genetically linked.(26:58):So I think that there is a real need in Alzheimer's disease to be able to block this vascular induced pathology. And an antibody like the fibrin neutralizing therapy could be positioned to be protective from the vascular induced immune-mediated neurodegeneration in this disease as well. I mean, ultimately, I think that we need to be thinking the terms of efficacy. So we want to have a drug that is efficacious, but we also want it to be selective. And the selectivity is really important because the immune system has so many protective functions. So if we block phagocytosis, we end up with more debris, decrease of neurorepair, anti-myelination. So by blocking a ligand here and not blocking, not eliminating a cell type or blocking a global pathway in this cell, but biologic a single ligand, I think we have been able to achieve this balance between efficacy, but also safety because we only block this neurotoxic populations and not the entire innate immune response that also has been beneficial for metastatic functions in the brain.Blocking NeuroinflammationEric Topol (28:19):So you're bringing up another critical concept about targeting the inflammation, this kind of goldilocks story of how much you interfere with the immune response and how much you are able to reduce the adverse pro-inflammatory effects. So that gets me to what if we don't know in any given patient how much fibrin is having a role in their Long Covid. Although we know it has to be a prominent feature because we saw it in, not just a hospitalized patient series that I mentioned we reviewed, but other papers as well. But what about if you just try to take on inflammation like through a GLP-1 drug or cGAS–STING or any of these really strong anti-inflammatory pathways. Do you see a difference in a generalized approach versus a specific approach that is really fibrin centered?Katerina Akassoglou (29:22):Yeah, so we have a focus actually on both because we wanted to dissect the downstream intracellular pathways of fibrin, and it's interesting that we can find specific inflammatory mediators that potentially can also be targeted as well, to be able to preserve that specificity, which I think is really important because if we don't preserve the specificity, we'll end up with a lot of adverse effects by eliminating major immune responses. But the point that you raised I think is really important because it's not enough to have an efficacious and selective drug if you don't know the patient population that will benefit from this drug. So I think that in addition to the drug discovery studies, it's important to develop also biomarker programs with both fluid biomarkers, but also imaging biomarkers to be able to identify the patient populations that will benefit from such treatment.(30:25):So if for example, a patient population has a fibrin deposition, blocking only downstream might not be enough, and it might be really important to neutralize this fibrin toxicity in the brain of patients. And with our target engagement studies, we show that at least in animal models, the antibody can be there. So I'm very encouraged by also programs that are going on now in the scientific community to develop noninvasive ligands to be able to image fibrin in the brain that are already tested in different patient populations like multiple sclerosis. Because I think we're going to learn so much from the biology as we start interrogating and asking these questions now in different patient populations.Eric Topol (31:14):I think that's a vital point you're making because the success of a clinical trial here in a clinical syndrome that is mosaic with lots of different types of pathways. If you can nail down the patients that would have the most to stand to benefit from a particular intervention, that the chance of you not missing the benefit that is matching the marker, what image marker or other markers is so vital. Well, we've talked, I think, about some fascinating discoveries that you and your colleagues have made. I mean, it's really extraordinary, and obviously we need this in Long Covid. But you know what, Katerina, it's almost made me think that you were warming up to this for three decades, that somehow or other you were working on all this stuff and then came Covid. Is that how you see it, that somehow or other you didn't know that all the work you were doing was going to wind up in this space?Katerina Akassoglou (32:18):Oh, I never thought I would work in a virology project. This collaboration started over Zoom with Warner Greene. We were both sheltering in place. It was the beginning of the pandemic, and the first reports were coming out about this puzzling coagulopathy. And our labs were hardly operational at the time, as you know, we had to close down our labs for a while. And however, this was a very big problem, and we thought that this is our role as scientists. If we feel that we can contribute and we have the tools to contribute, we felt that it's important that we pivot some part of our research, and even we wouldn't be doing this before, but it was important to pivot a part of our research and collaborate. And I think studies like this, this study would have been impossible without a team of collaborators. As you know, there were over 50 scientists involved at Gladstone, UCSF, UCLA, UCSD, Stanford University. Without collaboration, this study wouldn't be possible. So I'm really grateful to everyone who came together to solve this problem because I think that's what scientists should be doing. We should be solving problems as they arise.Eric Topol (33:41):Well, and also, I think a lot of people don't realize that, for example, when the Covid vaccines came along, people think, oh, well, it all got done in 10 months since the sequence of the virus, when in fact it took 30 years at least between all the factors that went into having an mRNA and sequencing virus and nanoparticles. And in many ways, your arc of this work is like that because it took three decades to have all the tools and the basic understanding, the antibody that you had developed for different reasons and this fascinating unraveling of what's going on in the model and undoubtedly in some patients at least as well. So before we wrap up, have I missed anything about this just remarkable work you've done?Katerina Akassoglou (34:33):Oh, thank you. I just want to thank you for this discussion and thank you for emphasizing the different areas and the different decisions that this pathway can have implications both for our understanding, our basic understanding of the blood brain immune interface, as well as also potential translation. And I think that the curiosity sometimes of how things work, I never thought it would work on Covid, like you mentioned at the beginning, but I think that basic science and curiosity driven science can sometimes lead to discoveries with translational implications that hopefully might benefit patients one day.Eric Topol (35:21):Yeah, well, undoubtedly it will. We're indebted to you, Katerina and all the folks that you have teamed up with, connecting the dots at the neurovascular interface. Phenomenal work and will follow the subsequent with great interest and it will likely not just a story about Long Covid, but other areas as well, so thank you.*********************************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informative!Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly help fund our summer internship programs.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

Jimmy goes on the road with RJ from Amuse News to Cayuga Lake Scenic Byway, Having a spirited conversation at the Finger Lakes Cider House to discuss how amazing (and misunderstood) cider wines are, the various wineries, the on-site farm, the local breweries, the gorges- and so much more!Big thanks to Finger lakes cider house, Hosmer Winery, Bet The Farm, The Cayuga Lake Scenic Byway team, and most importantly the Visit Ithaca team.Instagrams:The Cayuga Lake Scenic Byway!@cayuga_tourism@cayugascenicbywayFinger Lakes Cider House- Hannah & Garrett@flxciderhouse@discoverseneca@visitithacaHosmer Winery - Brooke, GMBet The Farm - Kit Kalfs, co-owner 

On this segment of Copper Country Today, host Todd VanDyke talked with Brad Barnett of Visit Keweenaw and Michael Stanitis from the Western Upper Peninsula Planning and Development Region about plans to reinvigorate interest in the Copper Country Trail National Byway. Copper Country Today airs throughout Michigan's Keweenaw Peninsula Sunday mornings at 7:00 on WOLV 97.7 FM, 8:00 on WCCY 99.3 FM and 1400 AM, and 9:00 on WHKB 102.3 FM. The program is sponsored by the Copper Shores Community Health Foundation. Copyright © 2024, Houghton Community Broadcasting, Houghton, MI.

The post By Way of Reminder – 2 Peter 1:12-15 appeared first on Bear Creek Church.

Thousands of Quakers left the American South in the 1800s because of their anti-slavery beliefs. And many of those Friends settled in Ohio. On today's episode, local historian Christine Snyder takes us on a trip along the Quaker Scenic Byway in Ohio and shares some of the remarkable stories of these Quakers — tales of daring rescues, an outspoken minister who prophesied war, and so much more. Put on your seat belt and join us for a very Quaker road trip.Visit our episode page for more information on the Quaker Scenic Byway, a transcript and discussion questions. Become a monthly supporter! Sign up for the Daily Quaker Message.

Kurt Henderson is a polymath. Before Kurt landed at the B-Corps certified company Byway Travel he was an entrepreneur, starting his first venture while at school. He began studying architectural technology at Brighton University but switched to digital media and design, a move he describes as "one of the best decisions I've ever made."Now he's a senior product designer at Byway, which coordinates 100% flight-free options for customers who want to travel sustainably and enjoy the journey as much as the destination.A year into working for Byway Kurt talks about the company's sustainable, ethical approach to travelling and working within a company culture that is respectful and inclusive. He goes on to talk about about "tech for good" and "it's important to give back while you are still growing yourself."But there's so much more to Kurt besides work and true to the 'giving back' ethos Kurt serves on the advisory board of ERIC, and guest lectures at Brighton University. He has been involved in youth businesses schemes and he advocates for diversity practices and policies. To unwind he plays tag rugby and basketball and music is still a big thing in his life.In this episode Kurt discusses:• working in a role you feel passionate about• freelancing and corporate culture vs start-ups• being patient and not expecting change instantly• consistency• finding time for yourself.• giving back.Mentioned in this podcastByway TravelEric ceative careers appB Corps UKUniversity of BrightonYou might also like to listen to:Lydia Carrington, sustainability manager at Edgbaston Stadium S2 E1Sanjukta Jitendhar, architect, Mikhail Riches, S1 E9Duncan Goose, CEO and founder of One Water and Global Ethics S1 E10ABOUTHost Sandra Kessell and her guests talk about how they progressed into their Green, Ethical, Sustainable or Socially responsible jobs and offer real-world insights into courses and pathways for following in their footsteps.Instagram ProGRESSTwitter ProGRESS CareersContent © Sandra KessellMusic © Lyze KessellEmail: Hello[at]myPro-GRESS.co.uk Hosted on Acast. See acast.com/privacy for more information.

Send us a Text Message.Linking the Travel Industry is a business travel podcast where we review the top travel industry stories that are posted on LinkedIn by LinkedIn members.  We curate the top posts and discuss with them with travel industry veterans in a live session with audience members.  You can join the live recording session by visiting BusinessTravel360.comYour Hosts are Riaan van Schoor, Ann Cederhall and Aash Shravah.Stories covered on this session include -Aer Lingus cancels more flights to deal with ongoing industrial strike action.In an attempt to get tourists to rather spend more money at their destinations, Thailand will soon shut down duty free upon arrival at most of their airports.Amadeus adds more UK rail content to the Cytric booking tool.Byway, a UK travel startup with a focus on sustainable, flight-free holidays, raises £5m in series A funding.ISON Travel acquires GLOBAL EXCELLENCE INC.TPConnects Technologies becomes the next Kyte API customer and adds more LCC content to their offering as a result.Qantas starts selling monthly lounge access for $99. Travelport adds AI to their trip search capabilities.Marriott International uses Spotnana tech to deploy a travel booking portal for SMEs.Traxo reports on a strong rise in corporate airline direct bookings in the first half of this year.Extra StoriesYou can subscribe to this podcast by searching 'BusinessTravel360' on Google Podcast, Apple Podcast, iHeart, Pandora, Spotify, Alexa or your favorite podcast player.This podcast was created, edited and distributed by BusinessTravel360.  Be sure to sign up for regular updates at BusinessTravel360.com - Enjoy!Support the Show.

The Great River Road National Scenic Byway, now recognized as an All-American Road and known as the "Happiness Highway," is a historic route that features seven bridges and Amtrak train access. It winds through 33 Wisconsin towns, offering attractions like locks and dams and interpretive centers. Notable stops in the north include Prescott's Freedom Park, the Native American Effigy Mounds in Hager City, and the Laura Ingalls Wilder Museum in Pepin. The central region highlights Trempealeau's Wildlife Refuge and Elmaro Vineyard, while the southern section boasts Prairie du Chien's Villa Louis Historic Site and the Driftless Café in Viroqua.Discover more about the Great River Road in the Discover Wisconsin episode, "The Wisconsin Great River Road – An All-American Road," available on discoverwisconsin.com and the Discover Wisconsin YouTube Channel here: https://bit.ly/3UUnW9wLearn more about the Wisconsin Great River Road at the following links:Website: https://bit.ly/4aGNkpdFacebook: https://bit.ly/3wVNlaRInstagram: https://bit.ly/4bRcgLqX: https://bit.ly/4dWvFN0Sponsored By: Friends of the Great River Road;https://bit.ly/4aGNkpdWisconsin Department of Transportation; https://bit.ly/3lE53Y4

Solo founder Cat Jones took the plunge on setting up a travel business right around the time the pandemic was hitting Europe in March 2020. Fast forward to summer 2024 and her curated package tour business, Byway, is announcing close of an oversubscribed £5.4 million Series A round (around $6.9M at current exchange rates). Learn more about your ad choices. Visit podcastchoices.com/adchoices

We sat down on location with our June beer sponsor, Byway Brewing. We talked with general manager Phil Sajn and head brewer, Mike Beck and had a BLAST!

Embark on a picturesque journey along California's Palms to Pines scenic byway. From palm-fringed valleys to towering pine forests, discover the diverse landscapes and hidden gems that make this drive a must for any road trip enthusiast.

What's up with you? Tee - You ever hit a deer? Chaufie - Bruiser Wolf, Raphy and Xavier So Based, Tenkay, Streamed Coachella, Washington DC, Gabe MTTG What's good to great? Tee - Kid had 4 pieces in an art show Chaufie - This dumb sandwich What's up with that?  What's up with the Tiktok ban Whatchu playing?  Tee - Fortnite, Monopoly GO! Chaufie - CoD and Zelda, PlayStation Portal - Bully Whachu watching?  Tee - X-Men 97, Loot, Avatar The Last Airbender, Fallout, Argyle, The Big Door Prize Chaufie - XMen 97, Loot, Conan Must Go , Eugene Leavy Reluctant Traveler, Fall Out, Baby Reindeer  Whatchu spinning? Tee - Record Store Day Releases, Rampage-Scouts Honor..By Way of Blood Chaufie - Amy Winehouse, Thurston Moore, a lot of Interpol

A photographic exhibition focused on the Harriet Tubman Byway is now on display at Old Town Hall in Wilmington.The exhibit “Landscapes of the Delaware Harriet Tubman Underground Railroad Byway” showcases the work of award-winning Delaware-based photographer Lynn Dilliplane and is on view until the end of this month.In this edition of History Matters, Delaware Public Media's Kyle McKinnon visited Old Town Hall and met up with Dilliplane, Wilmington's Historic Preservation Planner Debra Martin, and the Delaware Historical Society's Chief Curator Leigh Rifenburg to learn more about the exhibit and the Harriet Tubman Byway.

We caught up with DJ Williams about doing videos, his latest By Way of RVA, and his upcoming West Coast tour. Ep 418 #ATJPod Catch him: 03/15 to 03/17 NE 03/22 to 03/30 CO 04/10 to 04/14 CA More: https://www.djwilliamsmusic.com/ @allthatjampod on IG, FB, and Twitter - www.allthatjampod.com - Subscribe - leave a review - tell a friend.    Merch: https://t.co/QgtAisVtbV All That Jam is brought to you by Executive Producers Amanda Cadran and Kevin Hogan. Produced and edited by Amanda Cadran and Kevin Hogan. Mixed and Mastered by Kevin Hogan. Original Music by Aaron Gaul. Art by Amanda Cadran.

This is a story about the History, facts and description of the peak to peak scenic byway and a journey in story from along its 55 miles .. the towns, nature, activities , wildlife, history and beauty !” Thank you for listening to The Mountain-Ear podcast featuring the news and culture from peak to peak.SUBSCRIBE ONLINE and use the COUPON CODE PODCAST FOR A 10% Discount for ALL NEW SUBSCRIBERS https://www.themtnear.com/subscribe/ You can find us online by visiting https://www.themtnear.com/Find us on Facebook @mtnearYou can contact our editor at info@themountainear.com.Thank you for listening.

We caught up with DJ Williams about his last one Soldier Of Love and his upcoming release By Way of RVA Ep: 389 #ATJPOd More: https://www.djwilliamsmusic.com/ @allthatjampod on IG, FB, and Twitter - www.allthatjampod.com - Subscribe - leave a review - tell a friend. Merch: https://t.co/QgtAisVtbV All That Jam is brought to you by Executive Producers Amanda Cadran and Kevin Hogan. Produced and edited by Amanda Cadran and Kevin Hogan. Mixed and Mastered by Kevin Hogan. Original Music by Aaron Gaul. Art by Amanda Cadran.

Explore the Turquoise Trail National Scenic Byway and find your next road trip vacation with artist Kevin Box's larger than life origami sculptures, unique beers from New Mexico's oldest brewery at Santa Fe Brewing Company, authentic green chile cheeseburgers at The Mine Shaft Tavern in Madrid, and the challenging Santa Fe Century bike ride. Darley Newman shares where you can discover creativity and art at Origami in the Garden, master planned by the Frank Lloyd Wright School of Architecture. Entrepreneur Brian Lock relays why locals and travelers seek out his brewery for pints of New Mexico IPA and food truck tacos at Santa Fe Brewing Company. Darley joins locals to cycle along the Turquoise Trail through the old mining towns of Cerillos and Madrid, which have served as a filming location for hit movies and TV shows like Longmire and Wild Hogs. Get tips on where to stop, shop and eat along this iconic byway.

Robin Spielberg is a composer, music therapy advocate, and founder of the Mindful Music Association. She joins us to discuss her work and perform songs from her latest album, By Way of the Wind, live in our studio.

Renowned pianist Robin Spielberg has marked a milestone in her illustrious career with the release of her 24th album, "By Way of The Wind." Breaking away from her previous solo piano and piano/ensemble compositions, this latest offering presents a collection of Spielberg's original works fully orchestrated for a complete symphony and piano and string orchestra. The album represents a departure from her established repertoire and showcases her versatility in a fully orchestrated context. A remarkable aspect of "By Way of The Wind" lies in its unique recording process, as Spielberg collaborated with the Budapest Scoring Orchestra remotely over Zoom. Notably recognized for their work on the score of the acclaimed film "Parasite" and various other projects, the Budapest Scoring Orchestra contributed to the distinctive sound and texture of Spielberg's latest release. The album not only demonstrates Spielberg's artistic evolution but also reflects the adaptability of musicians and orchestras to virtual collaborations. "By Way of The Wind" stands as a testament to Spielberg's enduring creativity and ability to push the boundaries of her musical expression, captivating audiences with a symphonic journey that adds a new dimension to her extensive discography.Support WITF: https://www.witf.org/support/give-now/See omnystudio.com/listener for privacy information.

Continuing from Episode 96, Jacob Ryder teaches perspectives on temple worship through the use of apocryphal texts. Topics include: -The Ascension of Isaiah explained-What Isaiah saw in the the 7th Heaven-Exploring the Testament of Levi and the importance of the family-Looking at our temple experiences through the lens of the ancient prophets' texts.Jacob Ryder was born and raised by faithful converts to the Church of Jesus Christ of Latter-day Saints in Phoenix Arizona. He served a full-time mission in Southern California speaking both English and Tongan where he developed a love for teaching the restored gospel of Jesus Christ.Since his mission he has served in various church callings within the Elder's Quorum, Young Men's, and Sunday school. Jacob has a deep love for the Temple, priesthood, the second coming of Christ, and all things Israel. He spends all his free time studying the scriptures and has recently taken up learning Hebrew. Jacob shares his thoughts and testimony with others as the host of the, By Way of Commandment Podcast. Jacob is married to his High School sweetheart and they have 3 energetic children. Have you heard about the first-of-its-kind online temple class, "House of Learning: Understanding the Doctrine of the Temple"?! Registered students receive access to 19 lessons, over 6 hours of video/audio content, and list of over 50 additional resources, all geared towards helping you know and live what the temple aims to teach us. Click HERE to register now! Want to view the whole November Awake and Ascend conference? Recordings and transcriptions are available! Registration for All Access gets you the full two-day conference, including 9 presentations and the recorded Q&A session.With the holiday season upon us, the Latter-day Disciples are once again orchestrating the 2nd annual Secret Savior's project! Please help us by nominating your friends and family in need, or donating any amount. We aim to anonymously gift 20 families with $500 worth of gifts/groceries/cash. Please join us in our efforts to provide relief and love this Christmas season.

Meghan is joined by Jacob Ryder, host of the By Way of Commandment YouTube podcast, to discuss patterns of ascension in the temple, scripture, and apocryphal texts. Topics include: - Knowledge of truth as requisite for salvation- Approaching the temple with open-mindedness- The meaning of the names ‘Adam' and ‘Eve'- The Endowment as our story, not historyJacob Ryder was born and raised by faithful converts to the Church of Jesus Christ of Latter-day Saints in Phoenix Arizona. He served a full-time mission in Southern California speaking both English and Tongan where he developed a love for teaching the restored gospel of Jesus Christ. Since his mission he has served in various church callings within the Elder's Quorum, Young Men's, and Sunday school. Jacob has a deep love for the Temple, priesthood, the second coming of Christ, and all things Israel. He spends all his free time studying the scriptures and has recently taken up learning Hebrew. Jacob shares his thoughts and testimony with others as the host of the, By Way of Commandment Podcast. Jacob is married to his High School sweetheart and they have 3 energetic children. Have you heard about the first-of-its-kind online temple class, "House of Learning: Understanding the Doctrine of the Temple"?! Registered students receive access to 19 lessons, over 6 hours of video/audio content, and list of over 50 additional resources, all geared towards helping you know and live what the temple aims to teach us. Click HERE to register now! Want to view the whole November Awake and Ascend conference? Recordings and transcriptions are available! Registration for All Access gets you the full two-day conference, including 9 presentations and the recorded Q&A session.With the holiday season upon us, the Latter-day Disciples are once again orchestrating the 2nd annual Secret Savior's project! Please help us by nominating your friends and family in need, or donating any amount. We aim to anonymously gift 20 families with $500 worth of gifts/groceries/cash. Please join us in our efforts to provide relief and love this Christmas season.

The Cabin is presented by the Wisconsin Counties Association and this week we're featuring Fond du Lac County; https://bit.ly/3Lms7obThe Cabin is also presented by Jolly Good Soda, available in all your classic favorite flavors that we remember from childhood. The diet line offers 0 calories, 0 carbs, 0 sugars, and no caffeine – perfect for mixers or just enjoying on a warm summer day (or any day, for that matter); always Wisconsin-based, you can follow @jollygoodsoda on social for the latest on new flavors, fun promotions, and more. Learn more here; https://bit.ly/3TSFYY4   Campfire Conversation: Eric and Ana discuss Wisconsin's five designed scenic byways and why each is a beautiful drive, with a little help from our friends. Jon Jarosh from Destination Door County joins for a look at the Door County Coastal Byway, 66 miles of beauty and charming towns on the Door Peninsula along Highways 42 and 57, from Sturgeon Bay north to beautiful coasts, state and county parks, and towns like Egg Harbor, Fish Creek, Ephraim, Sister Bay, Ellison Bay, Gills Rock, Baileys Harbor, and Jacksonport. Mary Motiff from Bayfield County (and the mayor of its county seat, Washburn) joins for the Lake Superior Scenic Byway conversation. The Byway covers 70 miles along Highway 13 in Bayfield County, showing off the beauty of the northern coast of the state from near Ashland through Washburn and Bayfield over to Cornucopia, Port Wing, and Herbster with beaches, forest, orchards, wineries, and even the first National Tribal Park in the nation along the way. Josh Ostermann joins Eric and Ana in The Cabin for a look at the others (yes, pizza gets a mention.) The ​Nicolet-Wolf River Scenic Byway is the newest, covering 145 miles through the Nicolet National Forest and along the beautiful Wolf River, which has a National Scenic River designation. It winds through Forest, Langlade, Oneida and Vilas Counties along segments of Highways 55, 52, 32, and 70 with connections to a wide variety of multi-use, all-season trails. The Lower Wisconsin River State Scenic Byway covers 100 miles along Highway 60 from Lodi to Bridgeport by Prairie du Chien, giving you a nice cross-section of Wisconsin's incredible Driftless Area and the shifting courses of the Wisconsin River and its valley. Finally, Wisconsin's segment of the Great River Road gets covered as it runs along the Mississippi River from East Dubuque to Prescott. This multi-state byway actually begins in Minnesota and follows the Mississippi River for 10 states until it ends in New Orleans, Louisiana, but Wisconsin's segment is the most scenic (by many measures, not just ours!) It covers 250 miles, much of it along Highway 35, through 33 river towns. These include some of the oldest settlements in the state, the dynamic city of La Crosse as well as Prairie du Chien (the only place where two state designated scenic byways meet) and charming smaller towns like Trempealeau, Stockholm, Pepin, Alma, Fountain City, and Potosi. You can enjoy many scenic overlooks, with some great birding opportunities including bald eagles. All in all, Wisconsin's five designated scenic byways provide over 600 miles of road trip beauty and fun. Be sure to check out our Discover Wisconsin episode on the two coastal byways coming up!Links to more:Door County Coastal Byway: https://doorcountycoastalbyway.org/Lake Superior Scenic Byway: https://www.bayfieldcounty.wi.gov/855/Scenic-Byway and https://www.bayfield.org/Nicolet-Wolf River Scenic Byway: https://nicoletwolfriverbyway.com/Lower Wisconsin River Road Scenic Byway: https://www.facebook.com/Scenic60 or http://statetrunktour.com/routes/60-2/ Wisconsin's Great River Road: https://www.wigrr.com/

Adam Cox is accompanied by Cat Jones, the Founder of Byway, for a conversation exploring the distinctions between flight-free holidays and conventional vacations, as well as the rising appeal of the slow travel concept. Together, they examine the accessibility of multi-stop and airplane-free slow travel holidays, along with the existing obstacles that individuals encounter when embracing this form of travel. https://www.byway.travel/

Now that By Way of the Sea is fully streaming, listeners can "choose your own ending!"Listen in to this 2 minute BONUS feature, featuring Ending 3. In this ending, Elena chooses to continue her life with Kwesi, ignited by his love of family, tradition, and home.

Now that By Way of the Sea is fully streaming, listeners can "choose your own ending!"Listen in to this 2 minute BONUS, featuring Ending 2. In this ending, Elena chooses to lean into her blooming relationship with Silas.

Now that By Way of the Sea is fully streaming, listeners can "choose your own ending!"Listen in to this 2 minute BONUS, featuring Ending 1. In this ending, Elena chooses to adventure on her own and ends in Melissna, a small bay town where she begins her new life.

Now that By Way of the Sea is fully streaming, listeners can "choose your own ending!"Listen in to this 1.5 minute BONUS, featuring Ending 4. In this ending, Elena follows through with her father's wishes and travels to Auretta, to her arranged marriage and her new friend, August.

Our guest on Episode 61 of the Rider Magazine Insider Podcast is Steven Goode. On May 9, 2023, Goode embarked on the Great American Scenic Byway Tour to benefit the Parkinson's Foundation. He'll ride his Honda Gold Wing Tour through all 48 lower contiguous states, covering more than 15,000 miles over 60 days and riding the best scenic byway in every state. As a Parkinson's Champion, Goode will spread awareness of Parkinson's disease and raise funds for the Parkinson's Foundation. Click the links below to follow Goode's progress and support his efforts.  LINKS: Follow the GASBT on Facebook, Make a GASBT Donation

This month's episode features teaching from Wilkie Au during the first session of Two-Year Academy #40 in 2018. Wilkie explores how the stories in scripture can be a paradigmatic lens for viewing our current life experiences, helping us to see how God is showing up in our lives today and inviting us into a deeper felt knowledge of God's love for us. Wilkie reminds us that interacting with scripture using our full being—both our intellect and our imagination—can unlock deeper transformation of spirit. Wilkie Au is a spiritual director and Emeritus Professor of Theological Studies at Loyola Marymount University in Los Angeles, California, where he taught in the area of Christian spirituality and coordinated the graduate concentration in spiritual direction. He is the author of the award winning books, By Way of the Heart: Toward a Holistic Spirituality and The Enduring Heart: Spirituality for the Long Haul. He has also co-authored several books with his spouse, Dr. Noreen Cannon Au, including God's Unconditional Love: Healing Our Shame, where they explore the topic of this podcast episode. Their latest book together is Aging with Wisdom and Grace. Wilkie's books have been translated into Spanish, Polish, Chinese, and Korean and published in foreign editions in Great Britain, India, and the Philippines. Dr. Au has served as a member of editorial boards for scholarly journals and is a leader in the field of spirituality and formation for spiritual direction and pastoral ministry.

Discover Tennessee's Cumberland National Scenic Byway, a 160-mile driving route beginning at the majestic Cumberland Gap and winding to the storied Cumberland River in Celina. The byway highlights the rich history and breathtaking landscape that makes Tennessee a top tourism destination.    Show Notes: Visit CumberlandNationalScenicByway.com to plan your byway adventure in Tennessee. Support for this episode of Travel Embers is provided by the Tennessee Department of Transportation's Scenic Byway Program. Tennessee features more scenic byways than any other state East of the Mississippi River, with a collection of 10 nationally designated roadways that weave through the state's charming small towns, state parks and the natural landscape, highlighting the history, culture and scenic beauty that are all Tennessee trademarks. To learn more about Tennessee's Scenic Byways visit TN.gov/TDOT/ScenicRoadways. Sponsor Midroll:  3:06 – 3:41   Music: Thanks to singer and songwriter Cherokee Upton from Celina, Tennessee, for sharing her music with us to highlight the Byway. Find her on Facebook at Cherokee Upton Music.  Episode Cover Art: Photo of the Obey River in Fentress County, Tennessee, by photographer Chuck Sutherland. Travel Embers Theme Music: The Phoenix Song by Ed Brown and the Cumberland Band   Transcript Link: https://63a5845a-f816-419e-aeda-4da00220629b.usrfiles.com/ugd/63a584_d91b6f0e24454ed485edafa0f52ee336.pdf   Connect with the Travel Embers Podcast:  Website: Travelemberspodcast.com Instagram: @TravelEmbersPodcast

My guest this week is Cat Jones founder of B corp certified business Byway, who are on a mission to make slow travel mainstream. They offer 100% flight free holidays by train, boat and bus - and the journey is the holiday just as much as the destination. Their holidays are multi stop, often multi modal, often including sleeper trains (or boats!) and are journeys optimised for enjoyment, instead of speed or cost. Cat shows us how to travel in a more sustainable way, so we can still see the world and connect with other people and other cultures, without leaving such a huge carbon footprint.With alternative ways to travel it helps us see and save the planet at the same time. You can find out more about Cat's work on https://www.byway.travel/And follow her on Linkedin at Cat Jones. Join Lou on LinkedinFollow her @brave_newgirl on Instagram and get her books Brave New Girl- How to be Fearless, FEAR LESS and her Internationally Bestselling book DARE TO SHARE on Amazon or Waterstones or Barnes & Noble. UK & US versions available.Lou is the founder of Brave New Girl Media putting your story in the spotlight, showcasing your vision and supercharging your impact by guesting you on global podcasts  https://bravenewgirlmedia.comMusic by Melody LoopSupport the showGuest on global podcasts to increase your business growth, influence, and visibility Brave New Girl Media Dare to Share- bestselling guide to podcast guesting TAKE THE QUICK QUIZ to gain access to our FREE MASTERCLASS to become a podcast guesting pro

The year is 1814, and Elena's life is about to change forever. Along with a trunk of her mother's belongings, she is shipped away to her new life aboard the merchant ship, The Atlas. After the ship runs aground in a storm, Elena must adapt to life on a tropical island, along with the crew of the ship and those who wash ashore. Journey with us to discover the true meaning of life, love, and home in this original, regency era, immersive audio play.Episodes 1 and 2 premier March 17, 2023 with weekly episodes dropping each Friday at 12 pm edt, through May 19, 2023. With vocal talent by Brenna Patzer, Seth Rosenke, Karina Hilleard, John R. Smith Jnr, Enzo Leone, Gervais Weekes, and Sunny Snow.By Way of the Sea was written and produced by EraLore Studios, in collaboration with Stay Bizze.

Kris is a professional photographer who saw in web3 a new space to connect, share, and create his art. With a different vision not only on how to approach the blockchain but how to network and collab with other artist, Kris manage to spread his art among other hands, in a powerful cross-collab of his work “By Way of Water”. Time Stamps0:00 to 05:54 - Who's Kris05:55 to 09:10 - Photographers Transitioning09:11 to 15:02 - Putting Stuff Out15:03 to 22:33 - Experimenting with Tech22:34 to 26:22 - Art26:323 to 35:24 - Collabs35:25 to 40:45 - Collabs + Algo = Awareness40:46 to 48:29 - Next Season Predict48:30 to 53:14 - Onboarding and Security53:15 to 58:19 - What's Next for Kris58:20 to 1:03:45 - Photography Hot Take1:03:46 to 1:06:26 - Rounding OffGuest LinksTwitter: https://twitter.com/kristophershinnLink.tree: https://linktr.ee/kristophershinnUseful Links Based On ConversationOncyber: https://oncyber.io/Exchange: https://exchange.art/Fellowship: https://fellowship.xyz/SuperRare: https://superrare.com/Foundation: http://foundation.appManifold: https://manifold.xyz/Nifty Gateway: https://www.niftygateway.com/GlossaryOpen Editions: Open Editions are NFTs that have an unlimited number of copies available for purchase. Unlike limited editions that have a fixed number of copies, open editions can be minted continuously. This means that anyone can purchase an open edition NFT at any time, and the number of copies in circulation can continue to increase indefinitely.Airdrop: An airdrop is a marketing strategy used in the cryptocurrency industry where free tokens or coins are distributed to holders of a specific blockchain or cryptocurrency. Airdrops are usually used to increase awareness and adoption of new tokens, reward existing holders, or as a way to distribute tokens in a fair and decentralized manner. Airdrops can be one-time events or ongoing campaigns.Podcast Host: BunzyTwitter: https://twitter.com/0xBunzyBlockTalk || Pineapple WorkshopWebsite: https://pineappleworkshop.com/Twitter: https://twitter.com/poweredby_pwDiscord: https://discord.gg/geNCbMYsZY

Ah, the Cascade Loop Scenic Byway. This 440-mile route winds through the heart of Washington State's Cascade Mountains, revealing an abundance of natural beauty that is truly awe-inspiring. From the shore of Lake Chelan to the rugged peaks of North Cascades National Park, the landscape is both spectacular and diverse.   But the Cascade Loop is more than just a showcase of nature's wonders. We'll tell you about charming small towns along the way that offer a glimpse into the region's rich history and culture. Places like Leavenworth, with its Bavarian architecture, sausages and lively festivals, and Winthrop, with its Old West charm and cowboy spirit. Plus, Matt will take you on a culinary tour of the bakeries along the route and explain the differences between cinnamon rolls and morning buns.   In this episode, part one of our two-part series on the scenic drives through all three national parks in northwest Washington, we discuss the logistics and highlights of the Cascade Loop Scenic Byway.   Here's a link to the map of the loop that Karen promised Matt would draw.   Our Patreon account is now up and running with bonus content. Follow this link to check it out.   Don't forget to check out our new online merch store and www.dirtlander.com.   Subscribe to The Dear Bob and Sue Podcast on Apple Podcasts, Spotify, or wherever you like to listen, and if you've enjoyed our show, please leave us a review or rating on Apple Podcasts. Five-star ratings help other listeners find our show.   Follow us on Instagram at @mattandkarensmith, on Twitter at @mattandkaren, on Facebook at dearbobands, or check out our blog at www.mattandkaren.com.   To advertise on The Dear Bob and Sue Podcast, email us at mattandkarensmith@gmail.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Being in transition is hard. Owning your passions is hard. Becoming a mom... is hard. But just because it's hard, doesn't mean you're incapable. Just because it's hard, doesn't mean you're doing it wrong. Just because it's hard, doesn't mean you should give up. In this conversation with Founder of By Way of Us, Sarah Kim, we expand on various seasons of life that feel hard and how to navigate these hard seasons. We expand on the seasons where we know what we're being pulled from but don't yet know what we're being pulled towards. We expand on the seasons where we've let go of a past version of our Self and our life but haven't fully stepped into our renewed Self and life. We also expand on the seasons where we not only have fully stepped into our renewal but owned it. We touch on being true to your Self, the importance of vulnerability, and gaining a newfound confidence. If you're in transition, in any way, this conversation is especially for you! Explore the By Way Of Us Instagram hereSupport the showThank you for bringing this podcast into your present moment and thank you for consciously listening! Your presence is sincerely valued and appreciated. If you you enjoy this podcast, please share a rating and a review! ⭐️⭐️⭐️⭐️⭐️

MPR News Host Cathy Wurzer talked with a leading opponent of a tree removal project along a scenic stretch of highway in northern Minnesota. Then, she heard from one of the MnDOT leaders moving the project forward.

On todays segment of Open Tabs, I am joined by a brand new guest to the podcast, Eduardo. Being a great cook at a local brewery, Byway, Eduardo was the perfect guest to have on to review movies all about cooking. Together we reviewed Chef, directed and starring Jon Favreau. Our second movie is Burnt, starring Bradley Cooper, and for our third flick, we actually watched a Hulu original series, The Bear. Warning: you will be hungry after watching these. Chef (2014) Directed by Jon Favreau. A head chef quits his restaurant job and buys a food truck in an effort to reclaim his creative promise, while piecing back together his estranged family.Burnt (2015) Directed by John Wells. Adam Jones is a chef who destroyed his career with drugs and diva behavior. He cleans up and returns to London, determined to redeem himself by spearheading a top restaurant that can gain three Michelin stars.The Bear (2022) Created by Christopher Storer. A young chef from the fine dining world returns to Chicago to run his family's sandwich shop.https://msha.ke/thisseatstaken

2:41:19 – SUBJECT MATTER: Native Texan Bumper Stickers. Urban Sprawl. Stepping Foot In Texas 2007. Texan By Choice. By Way of Georgia and Tennessee. Blind Date. Maryville, TN. Sam Houston Schoolhouse. Houston Family Property. Smith & Wesson. Inheritance Weapons. Out of Jersey. Californication. Culture Shock. DFW Diversity. Texan By Choice. Raised in NJ. “Ain't My […]

Hour 1 -  Guest: Tom Martz, Bob Parker Tom Martz fills in for the vacationing Nick Reed this morning. Here's what he covers: The Ozark Run Scenic Byway is being proposed across the state of Missouri. The Ozark Run Scenic Byway will start in St. Louis, head south to the St. Francois Mountains, cross the Ozark National Scenic Riverways, head west past Bull Shoals Lake, and end near Branson. The Byway will be around 375-miles long. Tom and his guest, Bob Parker, speak about the ramifications of a Byway and rights owners along the Byway will lose. This would also affect businesses, land, and properties. Tom and Bob also talk about other Byways that already exists in Missouri.

In this episode of High Theory, Amit Pinchevski tells us about echoes. An echo is a sonic reflection of an emission bouncing back to its origin, which if delayed long enough sounds like a response. The echo of one's voice is constitutively not one's voice, and therefore gives an uncanny impression. Amit talks about the myths, metaphors, and materialities of echoes, the subject of his recent book. Amit Pinchevski is Associate Professor in the Department of Communication and Journalism at the Hebrew University of Jerusalem. He is the author of By Way of Interruption: Levinas and the Ethics of Communication (Duquesne University Press, 2005) and Transmitted Wounds: Media and the Mediation of Trauma (Oxford University Press, 2019), and Echo (MIT Press, 2022). Image: Echo Wall, Temple of Heaven, Beijing, 1987 by Nathan Hughes Hamilton, the original available here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

In this episode of High Theory, Amit Pinchevski tells us about echoes. An echo is a sonic reflection of an emission bouncing back to its origin, which if delayed long enough sounds like a response. The echo of one's voice is constitutively not one's voice, and therefore gives an uncanny impression. Amit talks about the myths, metaphors, and materialities of echoes, the subject of his recent book. Amit Pinchevski is Associate Professor in the Department of Communication and Journalism at the Hebrew University of Jerusalem. He is the author of By Way of Interruption: Levinas and the Ethics of Communication (Duquesne University Press, 2005) and Transmitted Wounds: Media and the Mediation of Trauma (Oxford University Press, 2019), and Echo (MIT Press, 2022). Image: Echo Wall, Temple of Heaven, Beijing, 1987 by Nathan Hughes Hamilton, the original available here. Learn more about your ad choices. Visit megaphone.fm/adchoices

I'm really excited to bring you today's guest because they're really shifting consumer behaviour on the sustainability front. It's not a retailer as such, it's a travel company – inspiring us all to ditch the flights, and enjoy the journey! Cat Jones is the founder and CEO at Byway, a travel company that creates flight-free “Slow travel” holidays for its customers. Founded in 2020 they have grown so fast they're having to turn off their marketing, and over 200 people a month are enjoying their trips. We're discussing how she's grown the business so far, juggling marketing vs service capacity, and (of course) how to re-educate consumers to make better, more low carbon buying decisions. Get all the links and resources we mention at https://ecommercemasterplan.com/podcast/?utm_source=captivate&utm_medium=episodenotes (eCommerceMasterPlan.com) This podcast uses the following third-party services for analysis: Chartable - https://chartable.com/privacy