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4 episodes with colleen cutcliffe
2 episodes with colleen cutcliffe
3 episodes with colleen cutcliffe
2 episodes with colleen cutcliffe
4 episodes with colleen cutcliffe
2 episodes with colleen cutcliffe
2 episodes with colleen cutcliffe
2 episodes with colleen cutcliffe
2 episodes with colleen cutcliffe
“You can improve your metabolism simply through your microbiome,” explains Colleen Cutcliffe, Ph.D. Colleen Cutcliffe, Ph.D., biochemist, microbiologist, and the co-founder and CEO of Pendulum Therapeutics, joins us today to dive deep into the science of the gut microbiome, covering everything from the gut-metabolism axis and increasing GLP-1 levels to gut-supporting foods. Plus: - Starting her company, Pendulum (~2:45) - Assessing microbiome health (~6:25) - The gut-metabolism axis (~8:55) - Increasing GLP-1 naturally (~10:00) - What is Akkermansia (~13:00) - How to increase Akkermansia (~16:55) - Microbiome-supporting foods (~18:53) - How to change your microbiome (~24:45) - Environmental factors & the microbiome (~26:20) - Stress & the microbiome (~28:00) - Reset the gut after antibiotics (~28:45) - The future of microbiome science (~31:05) - Fecal transplants (~34:00) - Exciting new science (~35:55) Referenced in the episode: - Follow Colleen Cutcliffe on Instagram (@drcolleencutcliffe) - Check out her company (https://pendulumlife.com/) - Learn more about their research (https://pendulumlife.com/pages/research-clinical-trials#nav-clinical-trial) - Research on microbiome diversity & pet ownership (https://pmc.ncbi.nlm.nih.gov/articles/PMC7058978/) - Research on Akkermansia & response to cancer immunotherapy This episode is made in partnership with Pendulum's Akkermansia. Made with a live strain of Akkermansia muciniphila, this supplement can improve gut health and digestion, reduce food cravings, and may even help stimulate GLP-1 production.*† Learn more at pendulumlife.com/MBG, and get 20% off all Pendulum product subscriptions for first orders. Discount applied at checkout. We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. †Based on pre-clinical studies. Not intended for weight loss. Learn more about your ad choices. Visit megaphone.fm/adchoices
What if the brain fog, sugar cravings, and stubborn fatigue you're feeling… starts in your gut? In this eye-opening episode, I sit down with Dr. Colleen Cutcliffe—Stanford PhD scientist and co-founder of Pendulum Therapeutics—to unpack the real reasons so many of us struggle with metabolic health, mood imbalances, and digestion. We explore how your gut microbiome shapes your energy, hormones, and weight every single day—even if the root cause began years ago. We break down the rise of leaky gut, the missing bacteria like Akkermansia that most probiotics ignore, and science-backed steps to start healing from within. If you've tried everything and still feel off, this conversation offers clarity—and real hope. Dr. Colleen Cutcliffe is a microbiome expert, Stanford PhD, and CEO of Pendulum Therapeutics. We Also Discuss: 03:55 – When I realized my heart issues weren't just physical 10:35 – How your gut is secretly running the show 15:54 – Yep… people are healing with poop transplants 24:52 – What antibiotics in childhood did to my metabolism 31:09 – Why your probiotic might be doing nothing 45:42 – The one gut strain you need (and probably don't have) 57:07 – I stopped craving sugar—here's what changed 01:05:08 – Before you try Ozempic…listen to this about your gut Thank You to Our Sponsors: 12 Tips: Ready to feel energized, focused, and vibrant—starting today? Download 12 Wellness Tips to Awaken Your Best Health and start transforming your body and mind now:
We have a mashup episode today, with several experts diving into the critical role of the microbiomes in our bodies. In this episode, Dr. Colleen Cutcliffe explains why fiber is essential for gut health and the challenges of cultivating anaerobic probiotics outside the body. Dr. Elisa Song discusses the impact of antibiotics on children's gut and mental health. Dr. William Li highlights how plant-based foods nourish gut bacteria, metabolism, and mental well-being. Dr. Nathan Bryan dives into the role of the oral microbiome in nitric oxide production, and Dr. Vincent Pedre explains how glyphosate contributes to leaky gut and health issues and examines how alcohol and environmental toxins impact weight management. Join us for today's in-depth exploration of how our microbiomes impact digestion, health, and overall well-being. Ep. 346 Gut Health: Unveiling the Science of the Microbiome with Dr. Colleen Cutcliffe [00:02:18]- [00:25:22] Dr. Cutcliffe highlights the importance of dietary fiber for supporting gut microbes, metabolism, and overall health and explains the challenges of growing anaerobic probiotics like Akkermansia outside the body. Ep. 360 Raising Resilient Kids: Insights from Holistic Pediatrician Dr. Elisa Song [00:12:17] - [00:24:28] Dr. Song highlights the often overlooked effects of antibiotics on gut and mental health, emphasizing the importance of educating preteens, teens, and young adults about how their daily choices impact their microbiome, brain function, and long-term health. [31:30]- [00:43:01] Why it is essential to understand how antibiotics and birth control impact the gut microbiomes of children and the importance of nurturing their resilience and restoring balance in their microbiomes over time. Ep. 354 Metabolism Myths Debunked: Weight Gain Insights with Dr. William Li [00:01:46] - [00:24:29] Dr. William William Li clarifies how bioactive compounds in plant-based foods feed gut bacteria, benefiting metabolism and mental well-being. He also highlights the importance of a healthy diet for gut health and explains how colonoscopy prep temporarily alters the gut microbiome. Ep. 379 Understanding Nitric Oxide and Its Impact on Our Health with Dr. Nathan Bryan [00:13:46]- [00:21:51] Dr. Nathan Bryan explores the crucial role of the oral microbiome in nitric oxide production and how mouthwash or fluoride products can disrupt that process, leading to higher blood pressure and reduced cardiovascular protection. [00:35:04]- [00:37:17] How, even though antibiotics and antiseptic mouthwash can disrupt the oral microbiome, the microbial communities can recover when given proper care and nutrition. Ep. 296 Secrets of Gut Microbiome and Glyphosate with Vincent Pedre [1:56-27:39] Dr. Vincent Pedre highlights how glyphosate disrupts the gut microbiome due to its mineral-binding and antimicrobial properties, leading to imbalances, leaky gut, and numerous health issues. [48:00- 1:02:15] The role alcohol, gut bacteria, and environmental exposure play in weight management and gut health, and how certain bacteria may lead to increased caloric extraction from food. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com
In this special "Best of Peptides" episode, you’ll get to dive into one of the most fascinating and controversial frontiers in health, fitness, and longevity. I’ve curated the best conversations from my discussions with peptide experts Jay Campbell, Colleen Cutcliffe, and Kyal Van Der Leest to give you an inside look at how peptides are revolutionizing performance, recovery, and overall well-being. Whether you’re new to peptides or already experimenting with them, this episode will give you a well-rounded perspective on their power, potential, and future in the world of health and performance. Full show notes: https://bengreenfieldlife.com/bestofpeptides Episode Sponsors: Feno: Transform your oral health with the Feno Smartbrush, the AI-powered device that delivers a perfect clean in just 20 seconds with 18,000 bristles and personalized insights for your whole-body health. Visit feno.co and use code BEN for $50 off—elevate your brushing routine today! SuppCo: Get early FREE access to SuppCo's supplement management app during its beta phase by visiting supp.co/BEN. Plus, podcast listeners will unlock early access to SuppCo’s founding membership when it launches in early 2025. Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20-25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Lumen: Optimize your metabolism with Lumen's handheld metabolic coach! Gain personalized insights for better energy, weight management, fitness, and sleep. Lumen even adapts to hormonal changes to keep you feeling your best. Take the next step at lumen.me/GREENFIELD and get 20% off! Organifi Green Juice: Start your day with essential superfoods that help detox the body, lower cravings, reduce stress, and reset your morning with a juice. Organifi Green Juice contains a clinical dose of ashwagandha and supports healthy cortisol levels, aiding in weight management. Go to organifi.com/Ben for 20% off your order.See omnystudio.com/listener for privacy information.
Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We'll explore Akkermansia's pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we're deficient in the first place. Plus, we'll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We'll also dive into the hotly debated topic of Akkermansia's impact on MS, unpacking both sides of the controversy. And, we'll touch on its promising influence on hormonal balance, from infertility to menopause. As someone who's deeply invested in science, I'm personally bullish on Akkermansia and trust Pendulum's products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Colleen Cutcliffe, PhD, Co-Founder and CEO of Pendulum Therapeutics Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern's Children's Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. THANKS TO OUR SPONSOR Pendulum: https://tinyurl.com/hzbxh75f EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Healthcare providers - Create a healthcare account with Pendulum to unlock wholesale pricing and get $50 off your first wholesale order with code WSKARA50 at https://tinyurl.com/hzbxh75f Not a practitioner but ready to try Pendulum probiotics for yourself? Take 20% off your first membership order with code KARA20 at checkout. https://tinyurl.com/2tjp3jb4 CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
In this episode of the DUTCH Podcast, recorded live at A4M World Congress, Colleen Cutcliffe, CEO and co-founder of Pendulum Probiotics, discusses the significant role of the gut microbiome in overall health and longevity. She shares insights into the innovative research and development of probiotics, particularly focusing on the strain Akkermansia, which has been shown to have profound effects on metabolic health, immune function, and even skin health. This episode also highlights: Challenges in probiotic development The evolving acceptance of probiotics in the medical community How diet fits into maintaining gut health The untapped potential of the microbiome in various health domains, including hormonal health and the gut-brain connection The need for more targeted research and products in this field Show Notes:Learn more about Colleen Cutcliffe and Pendulum Probiotics. Become a DUTCH Provider to learn more about using hormone testing in your practice.
Colleen Cutcliffe explores the microbiome's role during menopause, focusing on the estrobolome and gut bacteria's interaction with estrogen. She emphasizes the importance of gut health, particularly Acromantia, and discusses the negative impacts of birth control pills and antibiotics. Along with Dr. Mindy, they highlight essential microbes, dietary changes, and probiotics for wellness, and examine the long-term effects of weight loss drugs on the microbiome. Lastly, they stress measuring health through energy levels and the four pillars of well-being: nutrition, exercise, mental health, and the microbiome. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep271 Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern's Children's Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Check out our fasting membership at resetacademy.drmindypelz.com. Please note our medical disclaimer.
Curious about the connection between your gut, brain and blood glucose?Joining Krista on Almost 30 today is Colleen Cutcliffe, co-founder and Chief Executive Officer of Pendulum. In this episode, you'll learn about the probiotics industry and why Pendulum products are an effective solution in managing your gut health.Colleen has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. She is truly a wealth of knowledge and we're so excited for #Almost30Nation to learn more about their gut microbiome!Morning Microdose is a podcast curated by Krista Williams and Lindsey Simcik, the hosts and founders of Almost 30, a global community, brand, and top rated podcast.With curated clips from the Almost 30 podcast, Morning Mircodose will set the tone for your day, so you can feel inspired through thought provoking conversations…all in digestible episodes that are less than 10 minutes.Wake up with Krista and Lindsey, both literally and spiritually, Monday-Friday.If you enjoyed this conversation, listen to the full episode on Spotify here and on Apple here.
In this enlightening session, Dr. Jill Carnahan dives deep into the cutting-edge world of probiotics and the game-changing "Un-Hunger Hormone" with none other than biotech pioneer, Colleen Cutliffe, PHD. Join us as we explore the revolutionary GLP-1 Probiotic, a groundbreaking innovation that promises to boost GLP-1 production and transform metabolic health. Colleen Cutliffe, PHD, CEO and co-founder of Pendulum, shares her expertise on how this unique probiotic can effectively manage hunger, improve gut health, and support overall wellness.
In this episode, you'll get to discover the fascinating world of gut health with Dr. Adam Perlman, Chief Medical Officer at Pendulum Therapeutics. You'll explore how high-fiber, polyphenol-rich foods boost beneficial bacteria like Akkermansia, which support gut health and enhance athletic performance by maintaining gut lining integrity. Dr. Perlman also shares insights from his integrative medicine career, revealing practical tips to keep your microbiome strong in modern life, from polyphenol supplements to the synergy of probiotic strains. We'll also dig into cutting-edge research on GLP-1 triggering probiotics for metabolic health, how diet and exercise play crucial roles in overall wellness, and much more! For more insights on Pendulum's innovative work, check out my podcast with their co-founder, Dr. Colleen Cutcliffe, here. For Full Show Notes: https://bengreenfieldlife.com/glp1podcast Episode Sponsors: Joovv: Go to Joovv.com/ben and apply code BEN for an exclusive discount. BIOptimizers Mushroom Breakthrough: Go to bioptimizers.com/ben now and enter promo code BEN10 to get 10% off any order. Hiya: Go to hiyahealth.com/BEN for 50% your first order. Apollo: Head over to apolloneuro.com/bengreenfield and use code bengreenfield for $60 off. Timeline Nutrition: Go to timelinenutrition.com/BEN and use code BEN to get 10% off your order.See omnystudio.com/listener for privacy information.
Today, I'm joined by Colleen Cutcliffe, co-founder & CEO of Pendulum Therapeutics. Backed by actress Halle Berry, Pendulum is a microbiome biotech company disrupting probiotics with doctor-formulated metabolic health supplements. In this episode, we explore the links between gut health and metabolism. We also cover: • The science behind Pendulum's medical probiotics • Advocating for healthspan over healthcare • Where preventative health is headed Subscribe to the podcast → www.insider.fitt.co/podcast Subscribe to our newsletter → www.insider.fitt.co/subscribe Follow us on LinkedIn → www.linkedin.com/company/fittinsider Pendulum Therapeutics' Website: https://pendulumlife.com/ Pendulum Therapeutics' IG: https://www.instagram.com/pendulumlifeco/ Colleen's IG: https://www.instagram.com/drcolleencutcliffe/ - The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart workout solutions for fitness and health facilities. Fitt Talent: https://talent.fitt.co/ Consulting: https://consulting.fitt.co/ Investments: https://capital.fitt.co/ Chapters: (00:00) Introduction (01:28) Colleen's Background and Founding Pendulum (02:02) The Science Behind Pendulum's Innovations (05:50) Product Portfolio and Market Impact (08:02) Developing and Scaling Probiotic Solutions (11:19) Consumer and Healthcare Integration (15:18) The Future of Preventative Health (28:54) Advocating for Healthspan Over Healthcare (33:21) Conclusion
596 Colleen Cutcliffe: Co-Founder & CEO of PendulumOn this episode of The Kara Goldin Show, Colleen Cutcliffe, Co-Founder and CEO of Pendulum Therapeutics, shares her incredible journey of disrupting the probiotics industry and pioneering advancements in metabolic health. With over 15 years of experience in biotech and academia, Colleen leads Pendulum in developing science-backed products that address imbalances in the microbiome, transforming lives from the inside out.Colleen dives deep into how her scientific background and passion for health led to the founding of Pendulum, the challenges she faced in building the company, and how they've brought on investors like Sequoia Capital and the Mayo Clinic. We also discuss Pendulum's groundbreaking GLP-1 Probiotic and the exciting partnership with Academy Award® winner Halle Berry as the company's Chief Communications Officer.If you're interested in science, entrepreneurship, and the future of health, this episode is packed with insights into the world of probiotics, microbiome research, and what it takes to build a mission-driven company. Tune in for a conversation filled with lessons on innovation, leadership, and revolutionizing health from the inside out. Now on The Kara Goldin Show. To get 20% off of your subscription order, please use the code goldin at Pendulumlife.com/goldin. Offer is good for for a limited time and specifics apply. Please see site for details. Are you interested in sponsoring and advertising on The Kara Goldin Show, which is now in the Top 1% of Entrepreneur podcasts in the world? Let me know by contacting me at karagoldin@gmail.com. You can also find me @KaraGoldin on all networks. To learn more about Colleen Cutcliffe and Pendulum:https://www.instagram.com/pendulumlifeco/https://www.instagram.com/drcolleencutcliffe/https://pendulumlife.com/ Sponsored By:ShipStation - Get a 60-day free trial at ShipStation.com/KARA. Thanks to ShipStation for sponsoring The Kara Goldin Show!JLo Beauty - Head to JLOBeauty.com/KaraGoldin for a SPECIAL GIFT of FOUR FREE Masks and FREE Shipping.Shopify - Sign up for your one-dollar-per-month trial period at Shopify.com/kara Check out our website to view this episode's show notes: https://karagoldin.com/podcast/596
Dive into the world of entrepreneurship and personal growth with Dr. Colleen Cutcliffe, CEO and Co-Founder of Pendulum. In this episode, we explore the challenges and triumphs of building a groundbreaking health company from the ground up. Dr. Cutcliffe, Cofounder & CEO of Pendulum Therapeutics, , shares: The mindset required to persevere and achieve long-term entrepreneurial success How to build and maintain a strong team in the face of adversity Strategies for handling rejection and maintaining focus A personal story of overcoming academic failure and finding success The importance of faith and perspective in entrepreneurship Learn valuable lessons on resilience, teamwork, and personal growth from a scientist-turned-entrepreneur who's changing the health industry. Get my weekly newsletter - Adaptation Book Erik for your next event Start AIM7 for Free Promo code: BLUEPRINT for 20% off of all membership first orders → Pendulum Life Follow Dr. Cutcliffe & Pendulum on Instagram Quotable moments: "I decided a long time ago that health was how I wanted to make my mark." - Dr. Colleen Cutcliffe "To be a successful entrepreneur, you have to be a little bit of a psychopath. You have to be able to block out a bunch of the stuff that's coming your way." - Dr. Colleen Cutcliffe "It's about the hope and faith that you can make something. And it's about the team of people that you work with every day." - Dr. Colleen Cutcliffe "I'm not the best in class. I wasn't the person getting straight A's at Johns Hopkins, but I understand what people are looking for." - Dr. Colleen Cutcliffe ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals. Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High-Performance pioneer. He introduced sports science and athlete-tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - http://link.aim7.com/adaptation-newsletterSee omnystudio.com/listener for privacy information.
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern's Children's Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. https://pendulumlife.com/ If you are a healthcare provider, access provider education at wholesale pricing HERE.
This weeks guest is Dr. Colleen Cutcliffe. Dr. Colleen Cutcliffe is a researcher and a thinker with persistence. Throughout history, these are the human qualities that lead people to develop amazing products and lead projects for the world to benefit from. Her story is one of discovery, passion and caring. Dr. Cutcliffe holds a Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and a B.A. in Biochemistry from Wellesley College. Her scientific background is complemented by her experience in managing both research and operations teams in the biotech sector. Before founding Pendulum Therapeutics, she held senior positions at Pacific Biosciences and Elan Pharmaceuticals, where she was instrumental in developing various technological platforms. She is the co-founder and CEO of Pendulum Therapeutics, a biotechnology company focused on developing innovative solutions to improve gut health through microbiome-based interventions. With over 20 years of experience in the biotechnology industry, Dr. Cutcliffe has become a recognized leader in microbiome science, applying her expertise to bridge the gap between cutting-edge research and practical, consumer-facing health solutions. At Pendulum Therapeutics, Dr. Cutcliffe has led the development of novel probiotic formulations specifically designed to address metabolic diseases like type 2 diabetes. Her work has been pivotal in the growing recognition of the microbiome's role in human health, pushing forward the concept of targeted probiotics as a potential therapeutic option. Under her leadership, Pendulum Therapeutics has gained recognition for its scientific rigor and innovative approaches to personalized nutrition. Today, we discuss the story of her discovery and the fact that her work is the beginning of a hopeful wave of change for humans through gut microbiome manipulation. Dr. Cutcliffe helps us understand the basics of the microbiome, what helps it stay balanced and conversely, what upsets it. How does it support our metabolism and health in general. The main thrust of her work comes into the spotlight with Akkermansia mucinophilia, a keystone species for positive health. Please Enjoy my conversation with Dr. Cutcliffe, Dr. M
Unlock the secrets of your gut microbiome with Dr. Colleen Cutcliffe, CEO and Co-Founder of Pendulum. In this eye-opening episode, we explore the hidden world of bacteria living inside us and their profound impact on our health. Dr. Cutcliffe, a biochemistry expert with over 25 years of experience, reveals: How your microbiome changes throughout your life The surprising link between gut bacteria and mood Why diversity is key for a healthy microbiome Why akkermansia muciniphila is a crucial strain for gut lining health and GLP-1 production The truth about antibiotics and your gut health Groundbreaking research on probiotics for diabetes management Learn how nurturing your microbiome could be the key to better health, metabolism, and even blood sugar control. Don't miss this fascinating dive into the cutting-edge science of gut health. Get my weekly newsletter - Adaptation Book Erik for your next event Start AIM7 for Free Promo code: BLUEPRINT for 20% off of all membership first orders → Pendulum Life Follow Dr. Cutcliffe & Pendulum on Instagram Quotable moments: "We've co-evolved with these microbes. They play a super important role in health as well as disease." - Dr. Colleen Cutcliffe "Your gut is actually tied to every single biological system from your metabolism to your brain, to your immune system." - Dr. Colleen Cutcliffe "Diet is one of the most powerful ways that you can influence your microbiome." - Dr. Colleen Cutcliffe "We showed that in people with type two diabetes, we were able to lower A1C by 0.6 points and lower blood glucose spikes by 33%." - Dr. Colleen Cutcliffe "The microbiome is all the bacteria, viruses, and fungi that live in and on us." - Colleen Cutcliffe "Your gut bacteria help metabolize the food you eat, impacting your overall health." - Colleen Cutcliffe "Diversity in your diet is key to a healthy and resilient microbiome." - Colleen Cutcliffe "Antibiotics can decimate your microbiome, but a post-antibiotic regimen can help recover it." - Colleen Cutcliffe "Acromansiomucinophila plays a crucial role in maintaining your gut lining and stimulating GLP-1 hormone production." - Colleen Cutcliffe ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals. Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High-Performance pioneer. He introduced sports science and athlete-tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - http://link.aim7.com/adaptation-newsletterSee omnystudio.com/listener for privacy information.
Support the show and get 50% off MCT oil with free shipping – just leave us a review on iTunes and let us know!Your gut is not just involved in your gastrointestinal health. It also influences your metabolism, immune response, and even brain health. Dr. Colleen Cutcliffe, a microbiome scientist and CEO of Pendulum Therapeutics, reveals the surprising connections between the 100 trillion microbial cells in our gut and nearly every aspect of our health and longevity.After her daughter received multiple rounds of antibiotics as a preemie, Dr. Cutcliffe began to see the links between early antibiotic exposure and later chronic illnesses like diabetes, obesity, allergies, asthma, ADHD, and celiac disease - all centered around a decimation of the microbiome early in life. This launched her into microbiome science and the founding of Pendulum Therapeutics.Now, armed with DNA sequencing technology, Dr. Cutcliffe and her team are uncovering the key players in the gut microbiome, like the "next frontier" strain Akkermansia Muciniphila. They're developing targeted probiotics with the power of pharmaceuticals and the safety of traditional probiotics.Tune in to discover the interconnections of the gut-brain axis, the gut-metabolism axis, and why diversity in your microbiome is essential for healthy aging. Guest Bio:Dr. Colleen Cutcliffe is a biochemist, microbiome scientist, and the CEO and co-founder of Pendulum Therapeutics. She received her PhD in biochemistry and molecular biology from Johns Hopkins University and has over 25 years of experience managing biology teams in pharma, biotech, and academia. Pendulum Therapeutics is pioneering microbiome-targeted products with the efficacy of pharmaceuticals and the safety of probiotics to help restore metabolic health.Resources:Discover the groundbreaking ESS60 molecule, proven to extend life by 90%, at MyVitalC.com.Connect with Dr. Colleen Cutcliffe:- Website: https://pendulumlife.com/ - LinkedIn: https://www.linkedin.com/in/colleen-cutcliffe-9021449/ Connect with Christopher Burres- Website - https://www.myvitalc.com/- Website - https://www.livebeyondthenorms.com/- Instagram - https://www.instagram.com/chrisburres/- TikTok - https://www.tiktok.com/@myvitalc - LinkedIn - https://www.linkedin.com/in/chrisburres/
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter introduces a new format aimed at summarizing his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from each episode, covering diverse topics such as protein and muscle building with Luc van Loon, toe strength with Courtney Conley, VO2 max with Olav Aleksander Bu, liquid biopsies for cancer with Alex Aravanis, gut health and probiotics with Colleen Cutcliffe, and road safety with Mark Rosekind. Additionally, Peter shares any personal behavioral adjustments or modifications to his patient care practices that have arisen from these engaging discussions. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #304 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: How Peter keeps track of his takeaways from each podcast episode [5:15]; Luc van Loon episode: fat utilization, muscle protein synthesis, dietary protein, aging and inactivity, and more [8:45]; Behavioral changes that have come about from the conversation with Luc van Loon [23:45]; Courtney Conley episode: importance of toe strength and the impact of dedicated foot training [26:45]; Olav Aleksander Bu episode: the importance of VO2 max for lifespan, and the practicalities of measuring and improving VO2 max [36:45]; Behavioral changes that have come about from the conversation with Olav [56:00]; Alex Aravanis episode: liquid biopsies for cancer detection [1:01:30]; Colleen Cutcliffe episode: the importance of gut bacteria balance, and the potential therapeutic uses of probiotics, particularly Akkermansia [1:16:45]; Mark Rosekind: the significant issue of road fatalities and injuries, their causes, and practical safety measures to reduce risks [1:27:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
Ever wondered how the teeming world within our gut impacts everything from our mood to our metabolism? Today, we sit down with microbiome expert Dr. Colleen Cutcliffe, PhD to explore the hidden universe of our gut health. We unravel the complexities of the microbiome, emphasizing the importance of bacteria, viruses, and fungi in metabolizing the food we eat. Colleen shines a light on the common misconceptions about probiotics, prebiotics, and postbiotics, and why selecting high-quality supplements is crucial for optimal gut health. Together, we investigate the powerful influence of gut health on metabolic control and discuss the surprising connection between our gut and brain through the gut-brain axis. Follow Pendulum @pendulumlifeco Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) Basic Understanding Gut Health and Microbiome (13:17) What to Look For When Supplementing; What Works and What is a Waste of Your Money (16:50) Innovation (or lack thereof) of Gut Health Standards (24:16) Most Important Microbiome Strains (34:52) The Connection Between Gut Health and Metabolism (45:52) Gut Health Impact on Mental Well-Being (55:43) Gut Connection to Neurological Diseases (58:59) Ever Forward ----- Episode resources: Save 20% on any Pendulum gut health or metabolic health product with code EVERFORWARD at https://www.PendulumLife.com Watch and subscribe on YouTube
Episode 56: On this episode of The Shift, Christie (@quotesbychristie) speaks with Colleen Cutcliffe (@drcolleencutcliffe), co-founder and CEO of Pendulum - a revolutionary company aimed at creating probiotics that can help heal some ailments that come from unbalanced gut health. Colleen talks about how she started this journey of probiotics and why we all need to think about gut health, why failure is important, and her tips for balancing a startup and family. Take a listen... ----- Links: * Pendulum - use promo code SHIFT20 for 20% off on their first month membership order on PendulumLife.com * Pendulum's TikTok: @pendulumlife * I Feel That by Christina Scotch ----- Want to watch The Shift? Check us out on our YouTube channel here. ------ What is the best piece of advice you've ever received? That's what we ask on The Shift. Christina Scotch, creator of the popular Instagram account Quotes by Christie, asks celebrities, entrepreneurs, influencers, and other successful people about the words that inspired them. She finds out the quotes, mottos, mantras, and affirmations that inspired and motivated them to achieve more. Tune in to find the quote that might just shift your mindset and change your life.
Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph.D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance of GLP-1 for longevity, and practical tips for optimizing your microbiome health. Whether you're battling cravings or seeking to prevent diabetes and its associated risks, this episode sheds light on natural, effective strategies for a healthier life. Timestamp Highlights: (00:00:01) Introduction to GLP-1 and weight management (00:01:06) Colleen Cutcliffe, PhD, on natural ways to stimulate GLP-1 (00:04:41) The role of microbiome in regulating GLP-1 and cravings (00:16:00) The GLP-1 probiotic: benefits beyond weight loss (00:34:13) Dietary interventions to support GLP-1 probiotics (00:42:23) Personal experiences and results with GLP-1 probiotics (00:51:01) The different pendulum products and who should take them (00:59:23) How GLP-1 probiotics impact the gut lining and overall health (01:03:56) GLP-1 and its connection to longevity and disease prevention Sponsors: Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20 ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off ARRC LED | For More Information Visit ARRCLED.com Resources: Dave Asprey's NEW Book ‘Smarter Not Harder' is out now: https://daveasprey.com/books Instagram: @Dave.Asprey Pendulum GLP-1 Probiotics: https://pendulumlife.com (Code: Asprey20 for 20% off) Instagram: @pendulumlifecoSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
I am delighted to have Dr. Colleen Cutcliffe, the CEO and Co-founder of Pendulum, joining me today. Dr. Cutcliffe is a proud alumnus of Johns Hopkins, with over 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotech. Before starting Pendulum, she was the Senior Manager of Biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. In our discussion today, we dive into the emerging science of the gut microbiome, examining the effects of aging, antibiotics, nutrition, stress, travel, and menopause on gut health and discussing how vaginal and C-section deliveries differ in impact. We explore differentiators for various categories of bacteria and the roles of butyrate and fiber, looking at fecal transplants and the difference between probiotics, prebiotics, and post-biotics, and explaining why Akkermansia is an essential bacteria for regulating insulin satiety, fortifying the mucin layer, and facilitating targeted delivery of butyrate. Dr. Cutcliffe also shares her top tips for mitigating the effects of travel on the gut microbiome and offers a special discount for listeners. I am confident that you will find today's discussion with Dr. Colleen Cutcliffe engaging and enlightening. Stay tuned to learn how to adjust your lifestyle for a healthier gut microbiome. IN THIS EPISODE YOU WILL LEARN: The benefits of a vaginal delivery Various factors that disrupt the gut microbiome Why it is essential to get enough fiber in your diet What are the signs and symptoms of an unhealthy gut microbiome? The benefits of fecal transplants How the vagus nerve fosters communication between the gut and brain Why artificial sweeteners might not be as harmful to the gut microbiome as previously thought How prebiotics, probiotics, and postbiotics are interconnected and necessary for overall health The role of Akkermansia in the gut microbiome How to maintain a healthy gut microbiome while traveling Bio: Dr. Colleen Cutcliffe: Colleen Cutcliffe, PhD, is the CEO and Co-Founder of Pendulum. She has over 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Before starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Colleen Cutcliffe On the Pendulum Life website Use code THURLOW for 20% off your first order of Pendulum products.
In this episode, Dr. Colleen Cutcliffe explores antibiotic effects on gut microbiome, Akkermansia, GLP-1 stimulation, and implications of gut-brain communication on neurological disorders like Parkinson's and Alzheimer's. They dive into: 1. The evolution of antibiotics 2. The recent discovery of the keystone probiotic strain Akkermansia 3. Akkermansia's benefits 4. How neurons in the gut communicate with the brain Dr. Colleen Cutcliffe, Cofounder and CEO of Pendulum Therapeutics, is leading a dedicated team in their pursuit of groundbreaking and transformative solutions for gut health-related ailments, showcasing a remarkable passion for improving people's lives through revolutionary, safe, and effective microbiome interventions. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide
In this episode, Dr. Colleen Cutcliffe, CEO and co-founder of Pendulum, delves into the vital role of the gut microbiome and Pendulum's innovative products in optimizing metabolic health. She discusses the significance of the gut microbiome in metabolic health, immune function, and beyond. Dr. Cutcliffe offers practical advice for individuals navigating antibiotic treatments and emphasizes the importance of choosing high-quality probiotic supplements. Furthermore, she underscores the benefits of continuous glucose monitors and explores the possible synergies between Pendulum's Glucose Control and GLP-1 medications such as Ozempic for enhanced outcomes. Additionally, she outlines Pendulum's research focus on improving gut metabolism and elucidating the gut-brain connection as promising avenues for future intervention. Takeaways The gut microbiome plays a crucial role in metabolic health, cardiovascular health, immune response, and brain health. Microbiome transplants have shown promise in treating obesity and other health conditions. Antibiotics and diet can significantly impact the composition of the gut microbiome. Probiotics and prebiotics can help restore and support a healthy gut microbiome. Pendulum's glucose control product has been shown to lower A1C and blood glucose spikes in people with type 2 diabetes. Continuous glucose monitors provide valuable data on how different foods affect blood glucose levels. Combining Pendulum's glucose control with GLP-1 medications may offer additional benefits. Pendulum is focused on ongoing research and development to improve metabolic health and support patients in transitioning off medications. 00:00 Introduction and Background 02:01 Pendulum's Journey and Products 04:30 What is Akkermansia? 06:43 The Importance of the Gut Microbiome 09:22 Microbiome Transplants and Obesity 14:12 Factors Affecting the Microbiome 16:12 Recovering from Antibiotic Use 18:25 Probiotics and Prebiotics 20:07 GLP-1 and Pendulum's Approach 28:53 Pendulum's A1C Study 30:41 CGM and Glucose Control 33:00 Weight Loss and Glucose Control 35:21 Butyrate and Butyrate Supplements 36:30 Future Research and Conclusion 42:11 To visit Victory Men's Health Click HERE To visit Pendulum Click HERE Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation For questions email podcast@amystuttle.com Disclaimer: The Women Want Strong Men Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
In this episode, Dr. Will Cole is joined by CEO and Co-Founder of Pendulum, Colleen Cutcliffe. With an extensive background in academia, pharmaceuticals and biotechnology, Cutcliffe set out on a mission to bridge the gap between nature and medicine through cutting-edge, all-natural, and pharmaceutical-grade microbiome products. From the science of probiotics and the gut-brain connection, top contributing factors of poor microbiome diversity, and the truth behind recently popularized weight loss drugs, to the beneficial probiotic strain you need to know about for fighting disease and maintaining a healthy gut, this episode is your go-to guide to achieve a thriving microbiome. For all links mentioned in this episode: www.drwillcole.com/podcastPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Visit PendulumLife.com and use code WILLCOLE at checkout for 20% off your first membership month. Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Curious about the connection between your gut, brain and blood glucose?Joining Krista on Almost 30 today is Colleen Cutcliffe, co-founder and Chief Executive Officer of Pendulum. In this episode, you'll learn about the probiotics industry and why Pendulum products are an effective solution in managing your gut health.Colleen has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. She is truly a wealth of knowledge and we're so excited for #Almost30Nation to learn more about their gut microbiome!Morning Microdose is a podcast curated by Krista Williams and Lindsey Simcik, the hosts and founders of Almost 30, a global community, brand, and top rated podcast.With curated clips from the Almost 30 podcast, Morning Mircodose will set the tone for your day, so you can feel inspired through thought provoking conversations…all in digestible episodes that are less than 10 minutes.Wake up with Krista and Lindsey, both literally and spiritually, Monday-Friday.If you enjoyed this conversation, listen to the full episode on Spotify here and on Apple here.
In this interview, Dr. Jill Carnahan and Colleen Cutcliffe will explore the various aspects of Akkermansia, including its function in the gut, its role in supporting glucose control, and the innovative Pendulum Product that harnesses the power of this beneficial bacteria. Key Points Did you know that akkermansia is called a ‘keystone' strain and a key to microbial diversity Why the latest pendulum product, Glucose Control, is a game-changer when it comes to controlling your blood sugar Everything you wanted to know about losing weight naturally by increasing GLP-1 naturally in your gut. Link to Product: https://pendulumlife.com/discount/DRJILL20 Use code: DRJILL20 for 20% off membership of any product Professionals only Discount Code: WSDRJILL40
In this episode we sit down with Colleen Cutcliffe, the Chief Executive Officer and co-founder of Pendulum, to learn about a variety of lifestyle changes at the core of microbiome improvement, from fiber-rich diets to adopting pets. Colleen shares about the early stages of microbiome testing, and the significance of keystone bacteria that act as a metabolic powerhouse. We explore the intriguing relationship between probiotics and their impact on chronic illness, metabolic health, and practical tips for incorporating Akkermansia into your routine. Join us for an information packed episode, where we break down the science behind achieving optimal health through understanding the microbiome. Listeners are welcome to apply WILDHEALTH20 at pendulumlife.com for 20% off their purchase!
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more. We discuss: Colleen's background and current focus [4:45]; The basics of the microbiome [7:15]; The study of the human microbiome [15:15]; Categories of bacteria, and the implications on health of the rapid evolution of bacteria [19:45]; Methods for measuring and understanding the microbiome, and key indicators of microbiome health [28:30]; The important role of fiber for promoting gut health through the production of butyrate [38:30]; The case for manipulating gut bacteria via fecal microbiota transplant (FMT) [45:00]; Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function [50:15]; Factors that influence the vaginal microbiome [55:15]; The effect of gut microbes on obesity and challenges with fecal transplants in people [58:45]; Beneficial strains of gut bacteria and strains commonly found in probiotics [1:01:15]; The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” [1:09:45]; Considerations about how probiotic strains are produced, and more on the meaning of CFU [1:14:15]; Mitigating the effect of antibiotics on the microbiome [1:22:30]; What do we know about the effect of artificial sweeteners on the gut microbiome? [1:30:00]; Why Akkermansia is a keystone strain with implications for metabolic health and an individual's response to dietary interventions [1:36:15]; The essential steps necessary to develop a robust probiotic for optimal health support [1:45:45]; How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more [1:48:45]; Pendulum Therapeutics' commitment to rigorous product develop [2:06:30]; Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics [2:13:00]; Further studies of Akkermansia that have been proposed or are underway [2:20:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
What happens to your gut health when you take antibiotics? In this episode of the Biohacking Superhuman Performance podcast, we chat with Colleen Cutcliffe of Pendulum Life about the effects of our gut microbiome on our mental health, metabolism, energy levels, and learn to pinpoint signs of compromised gut health. Colleen dissects the nuances of probiotics, prebiotics, postbiotics, and synbiotics, and how these elements interact in our gut. Additionally, we examine the often-underestimated impact of antibiotics on our microbiome and how it can be combated with effective strategies. Lastly, we shift our focus to a specific strain of bacteria, known as akkermansia, and explore their role in food metabolism and mood regulation. In the same vein, we contemplate on the potential risks of long-term drug use including GLP-1, and delve into the impact of metformin on gut health. Colleen Cutcliffe is the CEO and Co-Founder of Pendulum Therapeutics. Colleen has over 20 years of experience managing and leading teams in biotech, pharma and academia. Prior to that, Colleen was a Scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral research at Northwestern's Children's Memorial Hospital, received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and received her B.A. in Biochemistry from Wellesley College. Thank you to our sponsors for making this episode possible: Healthgevity: Go to healthgev.com and use code LONGEVITY to save. Berkeley Life: Go to berkeleylife.com and use code NIDDBL to save. LVLUP: Go to lvluphealth.com and use code NAT10 for 10% off your order. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Colleen: Website: https://pendulumlife.com/ Facebook: https://www.facebook.com/PendulumLife Instagram: https://www.instagram.com/pendulumlifeco/ Linkedin: https://www.linkedin.com/company/pendulumco/ Twitter: https://twitter.com/Pendulum_Co What we discuss: (00:02) - Gut Health and Mental Health Connection (07:43) - Understanding Gut Health and Microbiome Terminology (19:16) - The Battle of Diets and Nutrition (26:37) - Antibiotics' Impact on Microbiome and Rebalancing Strategies (35:37) - Gut Microbiome and Healthy Aging (44:30) - Risks of Long-Term Antibiotic Use (58:39) - Benefits and Challenges of Akkermansia (01:04:49) - Live Probiotics and Colonization Importance Key takeaways: Nutrition is an important part of gut health. However, there isn't a particular diet that will make or break your gut health nor can you eat a nutrient-poor diet and expect probiotic supplements to keep your gut microbiome in good shape. Simply aiming to eat a balanced, nutrient rich diet is the way to go. While antibiotics have a negative impact on your gut health, it does come with a plus side. Given that antibiotics eliminate all bacteria – good and bad – the timeframe following an antibiotic treatment is a great time to focus on fixing your diet so you can repopulate your gut microbiome with the appropriate strains. While many of us blame our poor willpower for our cravings, it's usually our gut microbiome that is to blame. Luckily, there are specific strains one can supplement to help increase GLP-1 and GABA production to stimulate satiety and reduce anxiety, which helps reduce cravings overall.
Curious about the connection between your gut, brain and blood glucose?Joining Krista on Almost 30 today is Colleen Cutcliffe, co-founder and Chief Executive Officer of Pendulum. In this episode, you'll learn about the probiotics industry and why Pendulum products are an effective solution in managing your gut health.Morning Microdose is a podcast curated by Krista Williams and Lindsey Simcik, the hosts and founders of Almost 30, a global community, brand, and top rated podcast.With curated clips from the Almost 30 podcast, Morning Mircodose will set the tone for your day, so you can feel inspired through thought provoking conversations…all in digestible episodes that are less than 10 minutes.Wake up with Krista and Lindsey, both literally and spiritually, Monday-Friday.If you enjoyed this conversation, listen to the full episode here.
Colleen Cutcliffe, co-founder and CEO of the groundbreaking probiotics company Pendulum Therapeutics, started the company with a big goal in mind: changing the way people think about their gut health. And on her journey, she's had to challenge traditional – and sometimes outdated – thinking from the medical community and investors. In this episode, Colleen told us how she's been able to disrupt the industry, and gives her advice for making changes in any workplace. In this episode, Colleen shares: How she convinced the dean of her PhD program to let her stay – despite almost getting kicked out Why her daughter's birth inspired her to start Pendulum How she dealt with being told “no” The ways she's cultivated trust and transparency with her team Why she's got Halle Berry on speed dial PS: Skimm'rs get 20% off their first month of any Pendulum product(s) with code SKIMM9TO5.
In this episode of Habits and Hustle, I chat with Colleen Cutcliffe who gives us a step-by-step guide on all things gut health – understanding why optimization is key, why it's growing in popularity, how your gut is controlling you, and exactly what you should do to reclaim your gut microbiome. We also dive into how the gut is linked to your metabolism, the popular trend of glucose control and why we should be concerned about our glucose levels, and why an increasing number of people are seeking natural alternatives to metformin. Colleen Cutcliffe is the CEO and Co-Founder of Pendulum Therapeutics. Colleen has over 20 years of experience managing and leading teams in biotech, pharma, and academia. Before starting Pendulum Therapeutics, Colleen served as the Senior Manager of Biology at Pacific Biosciences, which is where she met her two co-founders. Prior to that, Colleen was a Scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral research at Northwestern's Children's Memorial Hospital, received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and received her B.A. in Biochemistry from Wellesley College. Use code “JENCOHEN” for 20% off of your first bottle of membership at pendulumlife.com What we discuss: (0:09:01) - Akkermansia's Role in Gut Health (0:17:41) - GLP-1 and Akkermansia in Metabolism (0:31:36) - Longevity Drugs and Glucose Control (0:35:01) - Glucose Control and Metabolic Supplement Benefits (0:45:16) - Gut Health Benefits and Quality Control (0:57:15) - Understanding Acromantia and Its Benefits Thank you to our sponsors: Pendulum: Head over to www.pendulumlife.com and use code JENCOHEN for 20% off. Therasage: Head over to therasage.com and use code Be Bold for 15% off Ketone IQ (HVMN): You can save 30% off your first subscription order of Ketone-IQ at HVMN.com/JEN Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Learn more from Colleen Cutcliffe: Website: https://pendulumlife.com/ Instagram: https://www.instagram.com/pendulumlifeco/ Learn more about your ad choices. Visit megaphone.fm/adchoices
It's time for a gut check! Morgan's guest this week is Dr. Colleen Cutcliffe, a biochemist and molecular biologist who is passionate about gut health. Colleen is the co-founder and CEO of Pendulum, a research-driven probiotics company on a mission to improve overall health by focusing on the gut. Learn more about the connection between balanced gut flora and a healthy body, and why she believes that certain probiotic strains (particularly Akkermansia) are the key to a healthy gut. Colleen also shares with Morgan the impact that stress, aging, and early antibiotic use can have on the gut microbiome and what people can do to get their gut back in check.
Curious about the connection between your gut, brain and blood glucose? Joining Krista on Almost 30 today is Colleen Cutcliffe, co-founder and Chief Executive Officer of Pendulum. In this episode, you'll learn about the probiotics industry and why Pendulum products are an effective solution in managing your gut health. Colleen has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. She is truly a wealth of knowledge and we're so excited for #Almost30Nation to learn more about their gut microbiome! Head to Pendulumlife.com and use code ALMOST30 to save 20% on your first month of any Pendulum product membership. We also talk about: Societal perception of probiotics What is akkermansia Symptoms of GI distress The connection between your blood glucose + gut Understanding GLP-1 How the microbiome impacts your metabolism The impact of genetics vs. lifestyle on your gut microbiome How to support your gut microbiome The connection between your gut + brain Resources: Website: pendulumlife.com Colleen's LinkedIn Pendulum LinkedIn Instagram: @pendulumlifeco Twitter: @Pendulum_Co Amazon Storefront: Pendulum Sponsors: IQ Bar | Get 20% off all IQBAR products by texting ALMOST to 64000. AG1 | If you want to take ownership of your health, try AG1 and get a FREE 1-year supply of Vitamin D AND 5 Free AG1 Travel Packs with your first purchase. Go to drinkAG1.com/ALMOST30. Osea | Head to OSEAMalibu.com and get 10% off your first order sitewide with code APOD30. Catori Life | Get a 20% discount with any purchase at catorilife.com. SKIMS | SKIMS Fits Everybody and more best-selling essentials are available now at SKIMS.com. Plus, get free shipping on orders over $75. To advertise on our podcast, please reach out to sales@advertisecast.com or visit https://www.advertisecast.com/Almost30. Learn More: almost30.com/learn almost30.com/morningmicrodose almost30.com/courses Join our community: almost30.com/membership facebook.com/Almost30podcast/groups Podcast disclaimer can be found by visiting: almost30.com/disclaimer. Find more to love at almost30.com! Almost 30 is edited by Marielle Marlys. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Here we discuss how to measure your gut microbiome, what the future of probiotic and gut microbiome research may hold and what Dr Cutcliffe's personal regimen is.
Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen
We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia.
We talk to Dr Colleen Cutcliffe about akkermansia muciniphila a probiotic that is involved in Some links are affiliate links so we will earn a commission when they are used to purchase products.
Join us on the latest episode! Our Guest: Colleen Cutcliffe, Co-Founder & CEO at PendulumWhat you'll get out of this episode: Metabolic health and microbiome science. Colleen's science background with a focus on improving gut health. Importance of gut microbiome in metabolizing sugars, carbs, and overall health. Pendulum's mission to restore and enhance gut health, addressing depletion of beneficial bacteria. Future potential of probiotics, including convenient drink formats, for improved well-being. To learn more about Pendulum Life: https://pendulumlife.com/Our sponsors for this episode are:Sage Growth Partners https://sage-growth.com/FlipMD by GoodRX https://www.goodrx.com/Quantum Health https://quantum-health.com/WHAT IS SLICE OF HEALTHCARE?The go-to site for digital health executive/provider interviews, technology updates, and industry news. Listed to in 65+ countries.
In this podcast, Dr. Colleen Cutcliffe, a PhD scientist and the co-founder and CEO of the microbiome company, Pendulum Therapeutics, discusses the role that different bacterium such as Akkermansia play in optimal gut health and function. Click here to view episode transcript: https://www.ifm.org/news-insights/akkermansia-gut-health-with-dr-colleen-cutcliffe/
Pendulum Co-Founder & CEO Dr. Colleen Cutcliffe and Pendulum Chief Communications Officer, Producer and Actress Halle Berry speak with Bloomberg's Ed Ludlow about Gut Health See omnystudio.com/listener for privacy information.
Dr. Colleen Cutcliffe, Cofounder and CEO of Pendulum Therapeutics, is leading a dedicated team in their pursuit of groundbreaking and transformative solutions for gut health-related ailments, showcasing a remarkable passion for improving people's lives through revolutionary, safe, and effective microbiome interventions. In today's episode with Dr. Colleen Cutcliffe, you'll hear us take a deep dive on: 1. The evolution of antibiotics and how their broad spectrum also harms the gut microbiome, potentially causing long-term issues like food sensitivities, chronic illnesses, and conditions beyond the digestive system, such as obesity and neurological disorders. 2. The recent discovery of the keystone probiotic strain Akkermansia, which resides in the gut lining, and its crucial role in preventing gut lining deterioration. 3. Akkermansia's benefits, including producing proteins that stimulate GLP-1, a hormone involved in regulating insulin and glucose response to prevent high glucose spikes and promote weight loss. 4. How neurons in the gut communicate with the brain, influencing cravings and other functions, and recent studies indicate that neurological conditions like Parkinson's and Alzheimer's may manifest in gut neurons before brain cells. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide Use code root20 for 20% off of your next purchase of Akkermansia - bit.ly/3p8qxkn
In this episode of the Thrive State Podcast, Dr. Kien Vuu (Doctor V) sits down with Dr. Colleen Cutcliffe, an expert in the microbiome and co-founder of Pendulum Therapeutics. They discuss the critical role of the microbiome in overall health, ways to optimize it, and the future of microbiome research. Discover practical tips and strategies for improving your gut health and overall wellbeing. Get 20% off your first order of Pendulum with code THRIVE20. Don't forget to follow Doctor V @doctorvmd, grab a copy of the #1 Amazon bestseller Thrive State at thrivestatebook.com, and download a free longevity guide at thriveto105.com. Episode Highlights: Dr. Cutcliffe's journey into microbiome research The importance of the microbiome in overall health How lifestyle choices impact the microbiome Strategies for optimizing your microbiome The future of microbiome research
In this episode of One day with Jon Bier, Jon talks with Colleen Cutcliffe to break down the complexities of microbiome science. Listen in as Colleen highlights the importance of replenishing and maintaining a thriving gut microbiome in a modern society that overlooks its role as a cornerstone of health and wellness. She discusses the importance of the bacterium Akkermansia and why its regulation is key to gut health. Finally, Colleen discusses signs to look for which indicate a recovering microbiome, and how to ensure that recovery following chemo or taking an antibiotic. Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. Colleen has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to co-founding Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Powerful Quotes by Colleen There are so many diseases that are associated with the depletion of Akkermansia that it's emerging as this keystone strain that you simply have to have. After you take an antibiotic, your microbiome is in its most vulnerable state. You have a blank slate, and what you decide to feed it now can make or break the playing field. Key Highlights A healthy microbiome “covers” us in bacteria, viruses, and fungi in order to be protected from allergens that are always present in our environment. Because of our modern focus on scrubbing ourselves clean of these bacteria, those allergens have the opportunity to directly interact with our immune system. This is why we're experiencing an increase in allergies, asthma, immune and autoimmune responses. Multiple studies, including one by Mayo Clinic, reveal that children who are consistently on antibiotics are systematically more prone to obesity, diabetes, celiac disease, allergies, ADHD, etc. This is all due to their microbiome being unable to recover from the prolonged administration of antibiotics. The microbiomes of the healthiest people are composed of 3-5% Akkermansia, which is a huge number for a single strain. Episode resources: Go to getneuro.com and use code “ONEDAY” at checkout for 15% off your entire order! Connect with Colleen Cutcliffe LinkedIn: Colleen Cutcliffe Connect with Jon Bier Instagram: @jonbier13 Twitter: @jonbier13 Facebook: @jonbier13
#sponsoredepisodeDid you realize how much your gut microbiome influences your metabolism, your weight and your overall health? Dr. Whitney talks with Colleen Cutcliffe, PhD, CEO and Co-Founder of Pendulum Therapeutics about how the gut microbiome works, optimizing the way your body handles the nutrients you consume, and choosing a probiotic that really works. Colleen Cutcliffe, PhD, is the CEO and Co-Founder of Pendulum. She has over 15 years of experience leading and managing biology teams in academia, pharmaceuticals and biotechnology. Prior to starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.You can find out more at www.modernmommydoc.com/podcastAbout Pendulum:Pendulum optimizes the metabolism of sugar and carbohydrates, reducing sugar cravings and energy slumps, boosting sugar and carb metabolism, AND supporting a healthy weight. Pendulum understands that whole-body health and wellness is tied to the complex ecosystem of microorganisms that is the microbiome, and that addressing imbalances in the microbiome transform people's lives from the inside.Their mission is simple: to improve the lives of millions through microbiome products. To that end, they create products that have the power and efficacy of a pharmaceutical with the safety and accessibility of a probiotic.To accomplish their mission, they developed an entirely new product–a medical probiotic. Medical probiotics are the bridge between nature and medicine, helping restore our bodies to their peak balance.To learn more about Pendulum Therapeutics AND to get 20% off your first month of Pendulum membership, go to www.pendulumlife.com and use code MODERN20
Tired of persistent, unhealthy food cravings? How about belly fat that just won't budge? Well, there are two things I want you to know: Number 1: You're NOT alone. The majority of people are what we call metabolically INflexible – and are therefore not able to burn body fat for fuel. Number 2: There IS something you can do about it. Colleen Cutcliffe – the CEO and co-founder of Pendulum Therapeutics – a revolutionary gut-health supplement company joins me to discuss akkermansia, and other incredibly powerful good gut bacteria strains, to support healthy weight and overall wellness. Show notes and transcript: EP 243 - The BEST Probiotic for Metabolism? Thank you to our sponsors~ Use code GUNDRY20 for 20% off your first month of a Pendulum membership at Pendulumlife.com. Pendulum probiotics are also available on Amazon. Get your quote today at Progressive.com and join the over 29 million drivers who trust Progressive. Receive 20% off new orders of the trusted ProHealth NMN supplements or 25% off subscriptions by heading to prohealth.com/gundry today. Keep you and your family safe with the AquaTru water purifier, just go to AquaTruWater.com and use the code GUNDRY20 for 20% off any water purifier. Get convenient, high-quality, affordable groceries delivered with Thrive Market. Get $80 in free groceries at thrivemarket.com/gundrypodcastTransform your sleep experience with Cozy Earth bedding, go to cozyearth.com/gundry
Colleen Cutcliffe, PhD, joins Integrative Practitioner associate editor, Avery St. Onge, to discuss how probiotics with targeted keystone strains like Akkermansia muciniphila can help restore optimal function to the gut microbiome and improve overall health. This episode is sponsored by Pendulum Therapeutics. Find us at integrativepractitioner.com or e-mail us at IPEditor@divcom.com. Theme music: “Upbeat Party” by Scott Holmes via freemusicarchive.org and “Carefree” by Kevin Mcleod via incompetech.com.
How much do we really know about the microbiome? What does it take to identify new probiotic strains and their associated health benefits? When should we leverage precise single strains and when is it more effective to use synergistic blends? I am grateful to talk again with the brilliant scientist and incredibly courageous entrepreneur, Dr. Colleen Cutcliffe. Colleen has over 20 years experience managing and leading teams in biotech, pharma, and academia — I just love picking her brilliant brain! She completed her postdoc research at Northwestern's Children's Memorial Hospital and earned her PhD in biochemistry and molecular biology from Johns Hopkins. In this episode of New Frontiers, we explore novel probiotic strains such as Clostridium buytricum, Clostridium beijerinckii & Anaerobutyricum hallii, discuss their synergy in producing short-chain fatty acids and potential to stimulate satiety-inducing GLP-1, and so much more! I commend Colleen and the team at Pendulum for their dedication to bringing new & challenging science and next-generation probiotics to the world. I sure learned a lot, and am sure you will, too. Let me know with a comment, review, and rating wherever you listen to New Frontiers! ~DrKF
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Colleen and her company Pendulum Life probiotics make unique strands of probiotics that help rebuild the gut lining and prevent leaky gut and help reverse type-2 diabetes. A double-blind randomized control study showed that users taking Pendulum's Glucose Control probiotic had a reduction in A1C by 0.6% and a reduction postprandial glucose spikes by 32.5%. Clearly there is more to weight loss than just calories in and calories out.Go to www.pendulumlife.com to get your probiotics and use the code "HACKED" in checkout for a discount. Timeline2:30 - What's wrong with the probiotic industry4:11 - Why most probiotics don't work5:35 - How Pendulum's probiotic works?12:52 - How Pendulum probiotics affect the brain14:46 - Can I still take Pendulum if I don't have weight issues?17:03 - How Pendulum affects cravings and is GLP agonist19:15 - How long does it take to see the effects22:16 - What happens if you stop taking it?25:32 - An explanation of Pendulums three products28:50 - Metformin versus Pendulum probiotics32:55 - Why butyrate is so important34:20 - New product coming soon with polyphenols35:40 - Why the products can appear pricey
IN THIS EPISODE OF THE HUMAN UPGRADE™…molecular biologist and biochemist Colleen Cutcliffe, Ph.D., returns to the show with brand new science about your gut. She's a regular guest because she and her team at Pendulum continue to uncover innovative ways to improve your gut health, your metabolism, your immune system, how your brain works and how long you live. This time, Akkermansia's back in the spotlight, with more than 300 new studies showing connections to weight, metabolism and immunity. A unique and novel probiotic strain (species of bacteria) naturally found in your gastrointestinal tract, Akkermansia muciniphila, directly interacts with your gut lining and helps regulate the mucus lining in your gut. Now, there's growing evidence showing Akkermansia to be a keystone bacterial strain.This conversation dives into the latest research and what it means for you. You'll learn how to apply this new knowledge and how to boost Akkermansia in your gut.SPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://pendulumlife.com and use promo code DAVEVIP to get 20% off your first month of membership. Watch this episode on YouTube!A Pre-Alcohol Probiotic to Offset a Rough Morning After: https://zbiotics.com/dave, use code DAVE to save 15% off your first order. Sleep Better on Natural Memory Foam: https://myessentia.com/daveasprey, use code DAVE to get an extra $100 off an Essentia mattress purchase on top of Essentia's Holiday 25% off sale. Through Dec. 31, 2022, only. Go Deep on Relaxation & Sleep: https://balooliving.com/dave, use code DAVE for a special discount. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
70% of your immune system is located in your gut- how are you supporting your microbiome for your best health? Colleen Cutcliffe, PhD, CEO and Founder of Pendulum joins on episode 39 of the Practically Healthy podcast to provide a science-based discussion on probiotics and how this rapidly emerging field is playing an important role in health and disease. Colleen shares the research and insights that lead to Pendulum's revolutionary probiotic, Akkermansia for mitigating metabolic syndrome. She explains that the Akkermansia muciniphila strain plays an important role in metabolism and the gut lining. The listener learns why low counts or depletion of Akkermansia is a problem, and can result in Inflammation, skin disorders, immune response and metabolism disorders. Dr. Melina reveals that she orders Akkermansia and mentions that it can reduce sugar cravings, anecdotally, for some. Colleen and Dr. Melina discuss science-based gut health facts and tips including significant factors that influence your microbiome other than diet, and foods you should avoid for your best gut health. The role of prebiotics, in concert with probiotics is addressed and Colleen shares research that gives insight into whether you need to keep taking probiotics or can discontinue once the microbiome is recolonized. The listener is cautioned about the lack of oversight in the supplement industry and practically healthy tips are shared to assist the listener in choosing a probiotic. Colleen offers listeners a free quiz on Pendulumlife.com to assess which Pendulum probiotic is best for their personal needs. Practically Healthy listeners receive a discount with code DRMELINA at Pendulumlife.com.
CEO and Co-Founder of Pendulum Life - Colleen is on a mission to heal, recover, and optimize our 2nd Brains!! (aka - our gut!) If you have ever had an issue with gut health, brain fog, or just want to know how to have the highest functioning gut to brian relationship possible, this is the episode for you! We go in-depth on what this new thing called Akkermansia is (legit unreal how great it is for your gut repair!) and what everyone wants to know - how to control glucose, so you don't add on unwanted fat!! Check out the episode and let Colleen and me know your questions, takeaways, and thoughts! (and get your super discount on Pendulum Life Products right here!) https://pendulumlife.com/ CODE: DAVID20 for 20% off storewide! Learn more about your ad choices. Visit megaphone.fm/adchoices
This week's conversation is with Dr. Colleen Cutcliffe, the CEO and Co-Founder of Pendulum Therapeutics.Colleen's extensive background includes a doctorate in Biochemistry and Molecular Biology from Johns Hopkins University, and over 20 years of experience managing and leading teams in biotech, pharma, and academia.In 2013, Colleen left her position as Senior Manager of Biology at Pacific Biosciences to start Pendulum, a company on a mission to improve health through first of its kind research and development in the gut microbiome.Pendulum's next generation probiotics are pioneering ways for people to transform their health and wellness by unlocking the power of the gut microbiome.I've been studying gut health and the microbiome for a long time now, and it's clear that Pendulum is on the forefront of creating meaningful change for people.I was fascinated to learn more about the topic from Colleen, and I hope you leave this conversation with a better understanding of the gut microbiome, and some applied insights on how improving your gut health can improve your life.-----Please support our partners!We're able to keep growing and creating content for YOU because of their support. We believe in their mission and would appreciate you supporting them in return!!To take advantage of deals from our partners, head to http://www.findingmastery.net/partners where you'll find all discount links and codes mentioned in the podcast.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Colleen Cutcliffe, CEO and Co-Founder of Pendulum Therapeutics, joins Chris on this episode of Revolution Health Radio to discuss how metabolic health is related to the gut microbiome, microbiome research, and probiotics. They'll talk about the problem with current probiotics, the opportunities being presented by novel strains and formulations, innovations in understanding the gut–metabolic and gut–brain connections, and the challenges of bringing anaerobic probiotics to the marketplace. The post RHR: The Microbiome Approach to Better Probiotics, with Colleen Cutcliffe appeared first on Chris Kresser.
Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF
In this episode, Dr. Jeffery Gladden speaks with Colleen Cutcliffe, Ph.D., the Co-founder and CEO of Pendulum Therapeutics, she has an impressive background in leading and managing biology teams. She's a scientist with a Ph.D. in Biochemistry and Microbiology from Johns Hopkins University and has held senior positions at bioscience and pharmaceutical firms. Pendulum is passionate about finding revolutionary, safe, and practical solutions to ailments that can be tied to your gut, and they have a goal to bridge nature and medicine. In this episode, they talk about probiotics and what led Colleen down this particular path. They mention that there are critical pathways in our microbiome that need to be operational: fiber→, butyrate + mucin regulation. They also talk about Pendulum and the benefits of the products they offer, and how the ability to manage glucose response is fundamental to healthy aging. Dr. Gladden introduces Colleen, and she introduces herself and how she got into what she does now. (1:30) Colleen talks about how you could approach the microbiome using DNA sequencing data science. She also mentions that if you could marry DNA sequencing technologies and network data science with pharmaceutical drug development, you could, with the microbiome, create products that had the efficacy of a drug but the safety of a probiotic. (2:40) Colleen mentioned a study that showed kids taking antibiotics before six months of age were also systematically more prone to obesity and type two diabetes as they age. Dr. Gladden mentions how antibiotics affect children. (4:00) Colleen mentions how butyrate is a small molecule that's been known for quite some time to have a really important role in a variety of different things. She says it is probably one of the most interesting things is that in our colon, our colon cells are the only cells in our entire body that use butyrate as their source of energy as opposed to glucose. (6:10) Dr. Gladden mentions how the fiber metabolism generates butyrate that feeds the intestinal lining. Dr. Gladden also mentions how fascinating it is that the butyrate is responsible for releasing GLP-1. (7:30) Colleen notes that if you are missing your microbiomes, ingesting fiber does not make much difference. (10:00) Dr. Gladden mentions some misconceptions about microbiomes and always compares the person's stool against an "ideal" stool. (11:59) Dr. Gladden talks about keystone strains and how what we are eating affects and influences them and the importance of eating different kinds of fibers. (14:00) Colleen talks about a study they did telling people to keep doing what they are doing and seeing a way to influence the microbiome and then have this impact on A1C and blood glucose. (17:00) Dr. Gladden talks about how microbiomes also affect appetites and that the microbiomes you grow affect what you crave. (19:00) Colleen mentions that the formulation is stable but needs to be refrigerated. She also mentions the five strains - Akkermansia muciniphila, Anaerobutyricum hallii, Bifidobacterium infantis, Clostridium butyricum, and Clostridium beijerinckii. (21:10) Colleen mentions some of the trials they have done and the approach they adopted. (24:10) Dr. Gladden talks about neuroinflammation and if Pendulum decreases neuroinflammation. (27:04) Colleen mentions that there is a known relationship between managing your blood glucose spikes and neural inflammation. (28:05) Dr. Gladden mentions what resting metabolic rate is and how it is measured. (32:44) Colleen says that if you have not had diversity in your diet, you may not have all the microbiomes you need to metabolize some food. She also talks about the regulation of mucin, which is the glue that keeps everything properly in place. (35:34) Colleen talks about what is on the drawing board for her at the moment. (39:15) Dr. Gladden talks about the connection between autism and microbiomes. (41:30) Collen talks about also looking out for and considering microbiomes as something additional in our intervention efforts. (43:25) Colleen gives out three takeaways for listeners. She mentions that food diversification is important to diversify our microbiome. The second thing is knowing that regulating how your body metabolizes sugar is important to healthy aging. Lastly, if you want to give yourself a boost to your microbiome, try the Pendulum glucose control strains paired with the proper diet. (45:39) Collen mentions the importance of people consulting their physicians when making changes that could affect their health. (48:00) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today! Website: Learn more about the next generation of gut health by visiting www.pendulumlife.com Instagram: @pendulumlifeco TikTok: pendulumlife Facebook: https://www.facebook.com/PendulumLife/ (For Gladden Longevity listeners, use code GL20 to subscribe and save 20% on your first month of Pendulum's subscription products.)
WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Capture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewideSkin Health and Healing: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://pendulumlife.com and use promo code "DAVEVIP" to get an exclusive discount.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you'll learn about emerging science that points to the effects of sugar on your gut microbiome and metabolism and the connections between sugar, your mental acuity and longevity.Biochemist and molecular biologist Colleen Cutcliffe, Ph.D., continually searches for new ways to improve your gut health and help you live longer. As CEO and co-founder of Pendulum Therapeutics, she works to turn scientific discoveries into real products that hack and heal your microbiome and its associated body systems. At Pendulum, her team identifies and isolates new bacterial strains then combines those new strains to create unique probiotics.“We really worked hard on ways to modulate post-postprandial glucose spikes through the microbiome,” Colleen says. The result? Pendulum's Glucose Control lowers blood glucose spikes by 33 to 34% for people with type 2 diabetes. “What we didn't realize was how many people who don't have type 2 diabetes were going to end up benefiting from it.”This conversation homes in on sugar management and a broad range of research that's exploring what you can do about managing your glucose to keep up your mental acuity (less brain fog, sharper thinking) and live a longer life. Science has discovered that as you age:You have reduced ability to metabolize sugar. Your microbiomes become less diverse and depleted of certain key strains that are important for sugar metabolism.If you improve glucose control, you see reduced neuronal inflammation and improved cognition.In the past decade, especially, sugar dominates a lot of the conversation around diet and health. It's been studied, substituted, moderated, restricted and demonized. With that type of focus, you lose the bigger point. “You can't completely cut out sugar,” Colleen says. “You do need sugar. Not all sugar is bad for you all the time. Every cell in your body, except for your colon cells, need glucose in order to survive, in order to replicate, in order to perform functions. All of the things that allow you to be a human being require some amount of sugar."She wants you to know what's happening to cause the change in metabolic processing as you age and what you can do about it, like:How to understand your blood glucose range and what fluctuations mean.How to track your blood glucose and what to do about peaks and dips.How to improve your focus, sharpness and mental endurance through diet and fitness.“I'm a scientist, so I'm always going to say more data is better,” Colleen explains. “[Especially] when you're trying to make improvements and you're making these micro-adjustments in your life, and you want to understand what impact are they having.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, I talk with Colleen Cutcliffe, PhD, CEO and Co-Founder of Pendulum Therapeutics, a microbiome solutions company based in San Francisco, CA. Pendulum has developed two live microbial therapies, Pendulum Glucose Control for the management of type II diabetes, and Pendulum Akkermansia for the support of gut health. Dr. Cutcliffe has over 20 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. She received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University, and her B.A. in Biochemistry from Wellesley College. In our conversation we discuss a number of questions related to live microbial therapies and next generation probiotics, including the following: · How did Pendulum get into the business of live microbial therapies? · How effective is this Pendulum Glucose Control for the treatment of type II diabetes, and what is the evidence? · For which patients is Glucose control indicated? · What is the evidence for the effectiveness of Pendulum Akkermansia for gut health? · How do you assess gut health? · How do you see the future of next generation probiotics in the treatment of chronic medical disorders? If you'd like to learn more about Pendulum's products, you can use my affiliate link here & if you buy a membership, you can take 20% off with code: EMERAN. As always, if you have any questions or comments, leave them below, and if you're enjoying our content, please take a second to like the video! Follow Dr. Mayer: https://linktr.ee/emayer
In this episode, I talk with Colleen Cutcliffe, PhD, CEO and Co-Founder of Pendulum Therapeutics, a microbiome solutions company based in San Francisco, CA. Pendulum has developed two live microbial therapies, Pendulum Glucose Control for the management of type II diabetes, and Pendulum Akkermansia for the support of gut health. Dr. Cutcliffe has over 20 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. She received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University, and her B.A. in Biochemistry from Wellesley College. In our conversation we discuss a number of questions related to live microbial therapies and next generation probiotics, including the following: · How did Pendulum get into the business of live microbial therapies? · How effective is this Pendulum Glucose Control for the treatment of type II diabetes, and what is the evidence? · For which patients is Glucose control indicated? · What is the evidence for the effectiveness of Pendulum Akkermansia for gut health? · How do you assess gut health? · How do you see the future of next generation probiotics in the treatment of chronic medical disorders? If you'd like to learn more about Pendulum's products, you can use my affiliate link here & if you buy a membership, you can take 20% off with code: EMERAN. As always, if you have any questions or comments, leave them below, and if you're enjoying our content, please take a second to like the video! Follow Dr. Mayer: https://linktr.ee/emayer
Colleen Cutcliffe, co-founder and CEO of Pendulum Therapeutics, is leading the charge on helping humanity live better, healthier, and longer lives. She does this through her study of the microbiome – what other scientists and doctors now know drives nearly every avenue of our bodies (think: cognition, aging, metabolism, Alzheimer's and Parkinson's). By creating a product that has the efficacy of a drug but safety of a probiotic, Pendulum Therapeutics has become the next generation health company with an entirely new thing – a medical probiotic. Pendulum is backed by Mayo Clinic, Meritech Capital, Sequoia Capital, Khosla Ventures and True Ventures, to name a few. Colleen's impressive background includes a Ph.D. in Biochemistry and Microbiology from Johns Hopkins University, but she shares that her role as a mother is what ultimately led her to co-found Pendulum Therapeutics. Listen in to hear Colleen's favorite sports moment (her bit on sports is phenomenal!), to learn what “leaky gut” is and how to fix it, and how to discover if you are aging healthy or not.
WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Cardiovascular Health: https://arterosil.com/dave20/, get a 3-pack and save up to 30% plus free shippingHealth Upgrades with Custom Lab Testing and Your Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipTrack Blood Glucose: https://www.levelshealth.com/Dave, sign up for the Beta groupSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSGo to https://pendulumlife.com and use promo code DAVEVIP to get an exclusive discount. IN THIS EPISODE OF THE HUMAN UPGRADE™… …we get into the gut. If you've listened to my podcast before you probably know how much the gut is a culprit in disease. I've invited experts on the show to explain how without the right balance of good bacteria in your gut, you can have inflammation, poor immune response, GI distress and much more. Your gut lining is like a fence, explains Colleen Cutcliffe, Ph.D. It needs maintenance and attention, because that “fence” is what guards your gut from bad bacteria and toxins. Without it, you lose a strong defense system.That's where Akkermansia comes in. This bacterial strain naturally found in the gastrointestinal tract helps regulate the mucus lining of the gut, while also fine-tuning immune responses. Only in recent years have people understood (and acted on) the gut microbiome's role in wellness or disease. Dr. Cutcliffe shares the research behind Akkermansia and why this probiotic is changing the gut health game.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dr. Colleen Cutcliffe speaks about a new Probiotic that helps to manage Diabetes with Dr. Ben Weitz. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] Podcast Highlights […]
On this episode I'm joined by Colleen Cutcliffe – the CEO and co-founder of Pendulum Therapeutics. Colleen and I reveal one of the most exciting discoveries in the history of microbiome research – akkermansia — and share how it could help YOU live a longer, healthier life. Full transcript and show notes: https://drgundry.com/Pendulum-Probiotics *This episode is sponsored by Pendulum Life - however, my opinions on Akkermansia muciniphila are my own. Thank you to our sponsors! Check them out: Get 15% off your order at TenThousand.cc and enter code GUNDRY. Just go to DrinkLMNT.com/GUNDRY for your FREE Sample. To save some bucks today on prescriptions, Go to GoodRX.com/GUNDRY. Go to www.naturenatesllc.com or Amazon and use the promo code DRGUNDRY to get 15% off your first order. Visit ThriveMarket.com/GUNDRYpodcast to start your risk-free membership and get your FREE gift and $20 discount today.
Colleen is a scientist with dual doctorates in biochemistry and molecular biology AND microbiome expert about healing oneself through the gut. She received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and is the co-founder of Pendulum Therapeutics. * About The Immunity Docuseries: Never has it been so critical and obvious that our health and immunity have to be a top priority. It's now up to us to make a choice: continue down a path of disease or do everything possible be to be at our peak health. Some of the questions explored in this series include: How can we be resilient to diseases and viruses to come? What actions can we take today to achieve peak immunity? What are the non-negotiables to building immunity? * This podcast wouldn't be possible without the support of Thrive Performance & Regenerative Medicine. A team prepared to go all-in with you to craft a personalized health plan to achieve your peak health. Book a free consult to start your health transformation at - https://thrivemedicineclinic.com/ * Thrive Medicine - @thrivemedicine Dr. Rhet Langley - @rhetmd Dr. Phillip Gallegos - @phillipgallegos_md Marc Champagne - @mchampagne
Today we talk to Colleen Cutcliffe, PhD, who is the co-founder and CEO of Pendulum Glucose Control, a probiotic product. We dive deep into the correlation between your gut microbiome and blood glucose levels, discussing the positive and negative effects of antibiotics on your body and especially the bodies of children. The effects the microbiome has on the mind and various diseases was obscure to all of us until recently research on this is showing more and more the link between these issues. Interview 3:30 How much do antibiotics affect microbiomes? 7:00 Is it possible to restore biome ecology? Why are children more vulnerable? 8:18 How much do C-sections affect human development? 11:20 What we know and don’t know 14:04 How Colleen is discovering the links between the gut and disease 18:22 Twin study on the microbiome and diabetes 21:36 What makes Pendulum different 25:52 Producing butyrate 33:25 Testing and what they’ve found 37:01 Should anyone not be taking Pendulum? 47:27 Prebiotics 52:15 Colleen’s advice to help your health 59:29 “The question we should all be asking our doctors is, ‘Do I really need to be taking this antibiotic? What can I do to help ensure that these other negative repercussions are things that I can counteract? How do I do that?’ And so I think it’s just being a little bit more cautious and aware of what those antibiotics are doing to us.” 8:00 Pendulum Website ( https://pendulumlife.com ) - Save 10% with code BABES10 *Linkedin: Pendulum Therapeutics* ( https://www.linkedin.com/company/pendulumco/ ) *LinkedIn: Colleen Cutcliffe* ( https://www.linkedin.com/in/colleen-cutcliffe-9021449/ ) *Facebook* ( https://www.facebook.com/PendulumLife/ ) *Twitter* ( https://twitter.com/Pendulum_Co ) *Instagram* ( https://www.instagram.com/pendulumlifeco/ ) Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donations
Use Code: MOLLIE10 – for 10% off the first bottle of a subscription order. BIO:Colleen Cutcliffe, Ph.D., is co-founder and CEO of Pendulum Therapeutics, a biotech startup in San Francisco. The company's mission is to fill the chasm that exists between unregulated supplements and prescription drugs. In this middle ground, Colleen envisions a future in which medicines are derived not from chemistry but one of nature's greatest gifts: the human body's microbiome.The safety and effectiveness of the company's first microbiome-bolstering probiotic, Pendulum Glucose Control, is welcome news for more than 120 million Americans living with diabetes and prediabetes, struggling to control their blood sugar.Colleen's pursuit is personal. Her daughter was born nearly eight weeks premature, spending the first month of life hooked up to machines. Doctors loaded her up with antibiotics, which is the standard, often lifesaving, a protocol for preemies. But the antibiotics wreak havoc on babies' microbiomes and could result in chronic conditions as adults [source]. Now 12 years old, Colleen's daughter already suffers from gut issues and food sensitivities that no one else in the family has.There has to be a better way – therapies that spare the microbiome while treating chronic conditions – and Colleen is determined to forge a new path. Prominent Silicon Valley venture capital firms are keen to help her: Sequoia Capital, True Ventures, and Khosla Ventures have invested $57 million since 2014.Colleen received a Ph.D. in biochemistry and molecular biology from Johns Hopkins University and a B.S. in biochemistry from Wellesley College. She completed her postdoctoral research at Northwestern Medicine's Lurie Children's Hospital of Chicago. Colleen lives in Menlo Park, Calif., with her husband, two daughters, and two rambunctious dogs.LINKS:https://www.instagram.com/pendulumlifeco/https://twitter.com/Pendulum_Cohttps://www.facebook.com/PendulumLife/https://www.linkedin.com/company/pendulumco/https://www.pendulumlife.comUse Code: MOLLIE10 – for 10% off the first bottle of a subscription order. SHOW NOTES:
Colleen Cutcliffe, CEO & Co-Founder at Pendulum Therapeutics, shared the story behind her title with us on Saturday, April 10th and Sunday, April 11th, 2021.Colleen has over 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.SUE SAYS"As a young girl growing up in the deep south to immigrant parents, Colleen's experience was not one of racism or discrimination. She recalls the lesson she learned from her parents was that every person, no matter their background, has the absolute power to chart their own course in life. She's taken these values of integrity, hard work and education and applied them directly to her company Pendulum. "Support this podcast at — https://redcircle.com/women-to-watch-r/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Drug resistant superbugs are they more of a threat than C19? Will they overwhelm the healthcare system, reverse a century's worth of medical progress ? Well talk about the real threat and the real God story, hope with DR. Colleen Cutcliffe founder of Pendulum Therapeutics. Also joined by Dr. Shiroko Sokitch, MD- author of HEALING WHEN IT SEEMS IMPOSSIBLE- 7 KEYS TO DEFY THE ODDS. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/michelle-m-mendoza/message
Colleen Cutcliffe is the cofounder and CEO of Pendulum Therapeutics which develops novel interventions that target the human microbiome to improve the lives of patients suffering from a variety of diseases. The company has raised so far $57 million from top tier investors like Sequoia Capital, Khosla Ventures, and True Ventures.
In this episode, we dive into a fascinating and essential topic—gut health—with the brilliant Colleen Cutcliffe, Ph.D., co-founder and CEO of Pendulum Therapeutics. Known for pioneering the next frontier of metabolic health through microbiome-targeted products, Colleen is changing the game in wellness, and she's here to share her journey from scientist to entrepreneur.With a Ph.D. in Biochemistry and Microbiology from Johns Hopkins and experience leading bioscience teams, Colleen's story is both inspiring and relatable. Her role as a mom led her to create Pendulum after her daughter was born prematurely and faced long-term risks from early antibiotics, sparking her mission to develop safe solutions for people with disrupted microbiomes.In this episode, we get real about:Why gut health is everything and how it affects your entire bodyWhat you should be doing to keep your gut in checkThe latest in gut health science and how it can empower you to live your healthiest lifeThe impact of early antibiotic use on the microbiome and chronic health issuesThis show is sponsored by Better Help. Get 10% off of your first month with the link betterhelp.com/sosheslaysPromo code SLAYS for 20% off membership first orders.For all things So She Slays visit our site!
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