Podcasts about pendulum therapeutics

Four years ago, Pendulum Therapeutics launched a breakthrough probiotic clinically shown to improve blood sugar in Type 2 diabetes. Do their newer products live up to the hype?References:Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation | BMJ Open Diabetes Research & Care New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! We've also curated some great playlists on specific episode topics including Diabetes and Gut Health!Have a nutrition question? Send an email to nutrition@quickanddirtytips.com. Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find Monica's blog and other programs at Nutrition Over Easy. Nutrition Diva is a part of the Quick and Dirty Tips podcast network. LINKS:Transcripts: https://nutrition-diva.simplecast.com/episodes/Facebook: https://www.facebook.com/QDTNutrition/Newsletter: https://www.quickanddirtytips.com/nutrition-diva-newsletterNutrition Over Easy: https://nutritionovereasy.comQuick and Dirty Tips: https://quickanddirtytipscom

Akkermansia muciniphila has been getting tons of great press recently. It’s a bacterium in the gut microbiome that thrives by supporting mucin production. However, its potential to enhance metabolic health and support weight management has paved the way for innovative probiotic solutions – which is exactly what a company called Pendulum has done! Pendulum’s products are backed by cutting-edge research showing clinical efficacy. Today we speak with Christina O’Connor, registered dietician and Senior Healthcare Account Manager at Pendulum Therapeutics. Christina breaks down all the latest research on Akkermansia muciniphila and how optimizing levels can lead to greater health outcomes. Today on The Lab Report: 5:30 Christina O’Connor on her love of microbiome science 8:40 Main drivers of gut health 10:15 Why should we care about Akkermansia? 13:05 Can you have too much? 15:20 GLP-1 effects of Akkermansia 17:25 Stool testing on probiotics and supporting colonization 22:40 What’s next for Pendulum? 24:15 The Fireball Additional Resources: Pendulum Discount Codes: Healthcare professionals: Create a provider account HERE for wholesale pricing and get $50 off with code WSGENOVA50. Not a healthcare professional or just want to try it out? Get 20% off your first membership order at pendulumlife.com with code GENOVA at checkout. Genova Connect Discount Code: Are you a consumer interested in checking your levels of Akkermansia? Use the promo code PENDULUM20 for 20% off Genova Diagnostics’ Akkermansia Assessment Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We'll explore Akkermansia's pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we're deficient in the first place. Plus, we'll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We'll also dive into the hotly debated topic of Akkermansia's impact on MS, unpacking both sides of the controversy. And, we'll touch on its promising influence on hormonal balance, from infertility to menopause. As someone who's deeply invested in science, I'm personally bullish on Akkermansia and trust Pendulum's products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Colleen Cutcliffe, PhD, Co-Founder and CEO of Pendulum Therapeutics Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern's Children's Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. THANKS TO OUR SPONSOR Pendulum: https://tinyurl.com/hzbxh75f EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Healthcare providers - Create a healthcare account with Pendulum to unlock wholesale pricing and get $50 off your first wholesale order with code WSKARA50 at https://tinyurl.com/hzbxh75f Not a practitioner but ready to try Pendulum probiotics for yourself? Take 20% off your first membership order with code KARA20 at checkout. https://tinyurl.com/2tjp3jb4 CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Can your gut bacteria help control cravings and metabolism naturally? In this episode, Dr. Melina Jampolis sits down with Dr. Adam Perlman, Chief Medical Officer at Pendulum Therapeutics, to explore the science behind GLP-1, gut health, and probiotics. Learn how key bacterial strains like Akkermansia Muciniphila and Clostridium Butyricum naturally boost GLP-1 hormone levels, reducing cravings and supporting metabolic health—without injections. Dr. Perlman shares insights from a six-week study, where 91% of participants reported reduced cravings, plus how polyphenols (pomegranate, grape seed, and green tea) enhance probiotic function. If you're curious about a natural alternative to weight management and blood sugar control, this episode is packed with expert insights!

Here we talk with Dr Adam Perlman the Chief Medical Officer of Pendulum Therapeutics about the microbiome and probiotics and their impact on metabolic health. We also look into the results from the clinical trials of the products

Here we talk with Dr Adam Perlman the Chief Medical Officer of Pendulum Therapeutics about the microbiome and probiotics and their impact on metabolic health. We also look into the results from the clinical trials of the products.

Christina is a registered dietitian and the Senior Healthcare Account Manager at Pendulum Therapeutics. She received her bachelor of science at James Madison University and completed her dietetic internship through the Virginia Department of Health.Christina has spent the majority of her career working in pediatrics. She fell in love with microbiome science during her role as a NICU dietitian at The Children's Hospital of the King's Daughters where she was instrumental in helping to bring to life one of the area's first donor human milk banks. In her spare time, she enjoys involving her two boys in growing, prepping, and cooking family meals.This episode is brought to you by Pendulum Therapeutics is a gut-health biotechnology company pioneering multi-strain probiotics with next-generation bacterial strains to support metabolic health and manage conditions like type 2 diabetes with products backed by rigorous science and clinical research. As the only probiotic company funded by the Mayo Clinic and trusted by figures like Halle Berry and Dr. Peter Attia, Pendulum is on a mission to improve millions of lives through products that combine pharmaceutical-grade efficacy with probiotic safety and accessibility.In today's episode, Nada sits down with Christina for a science lesson on gut health. The two discuss Christina's background as a NICU dietician and her current work at Pendulum Therapeutics. She describes the particulars of their foundational anaerobic bacteria and explains why most of us no longer have this vital strain as part of our biome. Christina shares how their products support our natural body functions and offers advice on which ones are best suited for those of us in our middle third. To find out more information and to purchase their products visit Pendulum's website. Follow on Instagram: @pendulumlifeco.Please follow us at @thisislibertyroad on Instagram; we want to share and connect with you and hear your thoughts and comments. Please rate and review this podcast. It helps to know if these conversations inspire and equip you to consider your possibilities and lean into your future with intention. Hosted on Acast. See acast.com/privacy for more information.

Dr. Adam Perlman is an internationally recognized expert in Integrative and Functional Medicine. He is currently the Chief Medical Officer at Pendulum Therapeutics, a biotech company focused on the microbiome and its connection to chronic disease. He formerly served as the Director of Integrative Health and Wellbeing at Mayo Clinic, Florida and Medical Director for Employee Wellbeing. Prior to that, he was Associate Vice President for Health and Wellness for the Duke University Health System, overseeing Duke Integrative Medicine and the Duke Diet Center. Dr. Perlman received his BA from Tufts University and his MD from Boston University School of Medicine, completing residencies in Internal Medicine and Preventive Medicine as well as a General Internal Medicine Research Fellowship at Boston Medical Center. He earned an MPH from the Boston University School of Public Health. He is also certified in Functional Medicine. Doctor Perlman has been practicing Integrative and Functional Medicine for over 25 years at some of the top healthcare systems in the Country. He specializes in the integration of lifestyle, diet and other complementary modalities, such as acupuncture or massage, with more conventional medicine in a whole person approach to treating a wide variety of conditions, such as chronic pain, gastrointestinal issues, and autoimmune disease.

Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)Ready to kickstart your gut health journey?Start here with this episode! Dr. Adam Perlman, Chief Medical Officer at Pendulum Therapeutics, joins the conversation to discuss their probiotics, designed to support gut health and metabolic conditions, including the microbiome's role in digestion and weight management.Bringing a wealth of expertise, Dr. Perlman was previously the Director of Integrative Health and Wellbeing at the Mayo Clinic in Florida and Medical Director of Employee Wellbeing. Before that, he held the role of Associate VP for Health and Wellness at Duke University Health System, overseeing Duke Integrative Medicine and the Duke Diet Center.In this episode, Dr. Perlman delves into the gut microbiome's influence on appetite and metabolism, highlighting the importance of Akkermansia, a keystone bacterium essential for gut health. We also explore fascinating studies on the gut microbiome's impact on weight management and insulin resistance, including experiments with genetically identical twins. Additionally, we discuss how the gut influences cravings and satiety and share tips on nurturing gut health for overall well-being. Want to dive deeper into the science of plant-based appetite suppressants? Listen to the full episode with Dr. Ed Walker now!If you're thinking of purchasing from Pendulum, use the code FRANCAVILLA at https://pendulumlife.com/ for a great discount. Check out Pendulum:Instagram: pendulumlifecoWebsite: pendulumLifeConnect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com

In this episode, you'll get to discover the fascinating world of gut health with Dr. Adam Perlman, Chief Medical Officer at Pendulum Therapeutics. You'll explore how high-fiber, polyphenol-rich foods boost beneficial bacteria like Akkermansia, which support gut health and enhance athletic performance by maintaining gut lining integrity. Dr. Perlman also shares insights from his integrative medicine career, revealing practical tips to keep your microbiome strong in modern life, from polyphenol supplements to the synergy of probiotic strains. We'll also dig into cutting-edge research on GLP-1 triggering probiotics for metabolic health, how diet and exercise play crucial roles in overall wellness, and much more! For more insights on Pendulum's innovative work, check out my podcast with their co-founder, Dr. Colleen Cutcliffe, here. For Full Show Notes: https://bengreenfieldlife.com/glp1podcast Episode Sponsors:  Joovv: Go to Joovv.com/ben and apply code BEN for an exclusive discount. BIOptimizers Mushroom Breakthrough: Go to bioptimizers.com/ben now and enter promo code BEN10 to get 10% off any order. Hiya: Go to hiyahealth.com/BEN for 50% your first order. Apollo: Head over to apolloneuro.com/bengreenfield and use code bengreenfield for $60 off. Timeline Nutrition: Go to timelinenutrition.com/BEN and use code BEN to get 10% off your order.See omnystudio.com/listener for privacy information.

Today, I'm joined by Colleen Cutcliffe, co-founder & CEO of Pendulum Therapeutics. Backed by actress Halle Berry, Pendulum is a microbiome biotech company disrupting probiotics with doctor-formulated metabolic health supplements. In this episode, we explore the links between gut health and metabolism. We also cover: • The science behind Pendulum's medical probiotics • Advocating for healthspan over healthcare • Where preventative health is headed Subscribe to the podcast → www.insider.fitt.co/podcast Subscribe to our newsletter → www.insider.fitt.co/subscribe Follow us on LinkedIn → www.linkedin.com/company/fittinsider   Pendulum Therapeutics' Website: https://pendulumlife.com/ Pendulum Therapeutics' IG: https://www.instagram.com/pendulumlifeco/ Colleen's IG: https://www.instagram.com/drcolleencutcliffe/ - The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart workout solutions for fitness and health facilities.  Fitt Talent: https://talent.fitt.co/ Consulting: https://consulting.fitt.co/ Investments: https://capital.fitt.co/ Chapters: (00:00) Introduction (01:28) Colleen's Background and Founding Pendulum (02:02) The Science Behind Pendulum's Innovations (05:50) Product Portfolio and Market Impact (08:02) Developing and Scaling Probiotic Solutions (11:19) Consumer and Healthcare Integration (15:18) The Future of Preventative Health (28:54) Advocating for Healthspan Over Healthcare (33:21) Conclusion

596 Colleen Cutcliffe: Co-Founder & CEO of PendulumOn this episode of The Kara Goldin Show, Colleen Cutcliffe, Co-Founder and CEO of Pendulum Therapeutics, shares her incredible journey of disrupting the probiotics industry and pioneering advancements in metabolic health. With over 15 years of experience in biotech and academia, Colleen leads Pendulum in developing science-backed products that address imbalances in the microbiome, transforming lives from the inside out.Colleen dives deep into how her scientific background and passion for health led to the founding of Pendulum, the challenges she faced in building the company, and how they've brought on investors like Sequoia Capital and the Mayo Clinic. We also discuss Pendulum's groundbreaking GLP-1 Probiotic and the exciting partnership with Academy Award® winner Halle Berry as the company's Chief Communications Officer.If you're interested in science, entrepreneurship, and the future of health, this episode is packed with insights into the world of probiotics, microbiome research, and what it takes to build a mission-driven company. Tune in for a conversation filled with lessons on innovation, leadership, and revolutionizing health from the inside out. Now on The Kara Goldin Show. To get 20% off of your subscription order, please use the code goldin at Pendulumlife.com/goldin. Offer is good for for a limited time and specifics apply. Please see site for details. Are you interested in sponsoring and advertising on The Kara Goldin Show, which is now in the Top 1% of Entrepreneur podcasts in the world? Let me know by contacting me at karagoldin@gmail.com. You can also find me @‌KaraGoldin on all networks. To learn more about Colleen Cutcliffe and Pendulum:https://www.instagram.com/pendulumlifeco/https://www.instagram.com/drcolleencutcliffe/https://pendulumlife.com/ Sponsored By:ShipStation - Get a 60-day free trial at ShipStation.com/KARA. Thanks to ShipStation for sponsoring The Kara Goldin Show!JLo Beauty - Head to JLOBeauty.com/KaraGoldin for a SPECIAL GIFT of FOUR FREE Masks and FREE Shipping.Shopify - Sign up for your one-dollar-per-month trial period at Shopify.com/kara Check out our website to view this episode's show notes: https://karagoldin.com/podcast/596

Dive into the world of entrepreneurship and personal growth with Dr. Colleen Cutcliffe, CEO and Co-Founder of Pendulum. In this episode, we explore the challenges and triumphs of building a groundbreaking health company from the ground up. Dr. Cutcliffe, Cofounder & CEO of Pendulum Therapeutics, , shares: The mindset required to persevere and achieve long-term entrepreneurial success How to build and maintain a strong team in the face of adversity Strategies for handling rejection and maintaining focus A personal story of overcoming academic failure and finding success The importance of faith and perspective in entrepreneurship Learn valuable lessons on resilience, teamwork, and personal growth from a scientist-turned-entrepreneur who's changing the health industry. Get my weekly newsletter - Adaptation Book Erik for your next event Start AIM7 for Free Promo code: BLUEPRINT for 20% off of all membership first orders → Pendulum Life Follow Dr. Cutcliffe & Pendulum on Instagram Quotable moments: "I decided a long time ago that health was how I wanted to make my mark." - Dr. Colleen Cutcliffe "To be a successful entrepreneur, you have to be a little bit of a psychopath. You have to be able to block out a bunch of the stuff that's coming your way." - Dr. Colleen Cutcliffe "It's about the hope and faith that you can make something. And it's about the team of people that you work with every day." - Dr. Colleen Cutcliffe "I'm not the best in class. I wasn't the person getting straight A's at Johns Hopkins, but I understand what people are looking for." - Dr. Colleen Cutcliffe ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals.   Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High-Performance pioneer. He introduced sports science and athlete-tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - http://link.aim7.com/adaptation-newsletterSee omnystudio.com/listener for privacy information.

This weeks guest is Dr. Colleen Cutcliffe. Dr. Colleen Cutcliffe is a researcher and a thinker with persistence. Throughout history, these are the human qualities that lead people to develop amazing products and lead projects for the world to benefit from. Her story is one of discovery, passion and caring. Dr. Cutcliffe holds a Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and a B.A. in Biochemistry from Wellesley College. Her scientific background is complemented by her experience in managing both research and operations teams in the biotech sector. Before founding Pendulum Therapeutics, she held senior positions at Pacific Biosciences and Elan Pharmaceuticals, where she was instrumental in developing various technological platforms. She is the co-founder and CEO of Pendulum Therapeutics, a biotechnology company focused on developing innovative solutions to improve gut health through microbiome-based interventions. With over 20 years of experience in the biotechnology industry, Dr. Cutcliffe has become a recognized leader in microbiome science, applying her expertise to bridge the gap between cutting-edge research and practical, consumer-facing health solutions. At Pendulum Therapeutics, Dr. Cutcliffe has led the development of novel probiotic formulations specifically designed to address metabolic diseases like type 2 diabetes. Her work has been pivotal in the growing recognition of the microbiome's role in human health, pushing forward the concept of targeted probiotics as a potential therapeutic option. Under her leadership, Pendulum Therapeutics has gained recognition for its scientific rigor and innovative approaches to personalized nutrition. Today, we discuss the story of her discovery and the fact that her work is the beginning of a hopeful wave of change for humans through gut microbiome manipulation. Dr. Cutcliffe helps us understand the basics of the microbiome, what helps it stay balanced and conversely, what upsets it. How does it support our metabolism and health in general. The main thrust of her work comes into the spotlight with Akkermansia mucinophilia, a keystone species for positive health. Please Enjoy my conversation with Dr. Cutcliffe, Dr. M

Unlock the secrets of your gut microbiome with Dr. Colleen Cutcliffe, CEO and Co-Founder of Pendulum. In this eye-opening episode, we explore the hidden world of bacteria living inside us and their profound impact on our health. Dr. Cutcliffe, a biochemistry expert with over 25 years of experience, reveals: How your microbiome changes throughout your life The surprising link between gut bacteria and mood Why diversity is key for a healthy microbiome Why akkermansia muciniphila is a crucial strain for gut lining health and GLP-1 production The truth about antibiotics and your gut health Groundbreaking research on probiotics for diabetes management Learn how nurturing your microbiome could be the key to better health, metabolism, and even blood sugar control. Don't miss this fascinating dive into the cutting-edge science of gut health. Get my weekly newsletter - Adaptation Book Erik for your next event Start AIM7 for Free Promo code: BLUEPRINT for 20% off of all membership first orders → Pendulum Life Follow Dr. Cutcliffe & Pendulum on Instagram Quotable moments: "We've co-evolved with these microbes. They play a super important role in health as well as disease." - Dr. Colleen Cutcliffe "Your gut is actually tied to every single biological system from your metabolism to your brain, to your immune system." - Dr. Colleen Cutcliffe "Diet is one of the most powerful ways that you can influence your microbiome." - Dr. Colleen Cutcliffe "We showed that in people with type two diabetes, we were able to lower A1C by 0.6 points and lower blood glucose spikes by 33%." - Dr. Colleen Cutcliffe "The microbiome is all the bacteria, viruses, and fungi that live in and on us." - Colleen Cutcliffe "Your gut bacteria help metabolize the food you eat, impacting your overall health." - Colleen Cutcliffe "Diversity in your diet is key to a healthy and resilient microbiome." - Colleen Cutcliffe "Antibiotics can decimate your microbiome, but a post-antibiotic regimen can help recover it." - Colleen Cutcliffe "Acromansiomucinophila plays a crucial role in maintaining your gut lining and stimulating GLP-1 hormone production." - Colleen Cutcliffe   ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals.   Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High-Performance pioneer. He introduced sports science and athlete-tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - http://link.aim7.com/adaptation-newsletterSee omnystudio.com/listener for privacy information.

Dr. Perlman is the Chief Medical Officer at Pendulum Therapeutics, bringing a wealth of experience in integrative and functional medicine. Before joining Pendulum, he held several prestigious positions, including senior associate consultant in General Internal Medicine at Mayo Clinic, Associate Vice President for Health and Wellness at Duke University Health System, and Executive Director for Duke Integrative Medicine.   Earlier in his career, Dr. Perlman was the Executive Director of the Institute for Complementary and Alternative Medicine at UMDNJ, where he also served as an Associate Professor and held the Hunterdon Endowed Professorship in Complementary and Alternative Medicine.   He earned his BA from Tufts University, his MD from Boston University School of Medicine, and completed residencies in Internal and Preventive Medicine at Boston Medical Center, where he also earned an MPH from the School of Public Health.   Dr. Perlman is a fellow of the American College of Physicians and has served on numerous boards and committees. He is a past chair of the Academic Consortium for Integrative Medicine & Health and currently serves on the consortium's Senior Advisory Group. His clinical focus lies in integrating lifestyle, nutrition, and complementary medical modalities to treat complex conditions and enhance overall well-being.

Support the show and get 50% off MCT oil with free shipping – just leave us a review on iTunes and let us know!Your gut is not just involved in your gastrointestinal health. It also influences your metabolism, immune response, and even brain health. Dr. Colleen Cutcliffe, a microbiome scientist and CEO of Pendulum Therapeutics, reveals the surprising connections between the 100 trillion microbial cells in our gut and nearly every aspect of our health and longevity.After her daughter received multiple rounds of antibiotics as a preemie, Dr. Cutcliffe began to see the links between early antibiotic exposure and later chronic illnesses like diabetes, obesity, allergies, asthma, ADHD, and celiac disease - all centered around a decimation of the microbiome early in life. This launched her into microbiome science and the founding of Pendulum Therapeutics.Now, armed with DNA sequencing technology, Dr. Cutcliffe and her team are uncovering the key players in the gut microbiome, like the "next frontier" strain Akkermansia Muciniphila. They're developing targeted probiotics with the power of pharmaceuticals and the safety of traditional probiotics.Tune in to discover the interconnections of the gut-brain axis, the gut-metabolism axis, and why diversity in your microbiome is essential for healthy aging. Guest Bio:Dr. Colleen Cutcliffe is a biochemist, microbiome scientist, and the CEO and co-founder of Pendulum Therapeutics. She received her PhD in biochemistry and molecular biology from Johns Hopkins University and has over 25 years of experience managing biology teams in pharma, biotech, and academia. Pendulum Therapeutics is pioneering microbiome-targeted products with the efficacy of pharmaceuticals and the safety of probiotics to help restore metabolic health.Resources:Discover the groundbreaking ESS60 molecule, proven to extend life by 90%, at MyVitalC.com.Connect with Dr. Colleen Cutcliffe:- Website: https://pendulumlife.com/ - LinkedIn: https://www.linkedin.com/in/colleen-cutcliffe-9021449/ Connect with Christopher Burres- Website - https://www.myvitalc.com/- Website - https://www.livebeyondthenorms.com/- Instagram - https://www.instagram.com/chrisburres/- TikTok - https://www.tiktok.com/@myvitalc - LinkedIn - https://www.linkedin.com/in/chrisburres/

In this episode, we are diving into the transformative world of gut heath with a focus on the keystone gut bacteria: Akkermansia. Here to help us learn more about Akkermansia is my guest, Christina O'Connor, RD. Christina is a registered dietitian with a rich background in microbiome science. From her early days in pediatrics to her current role at Pendulum Therapeutics, Christina has been a passionate advocate for understanding and harnessing the power of the microbiome to improve health outcomes. Stay tuned as we explore everything from the basics of Akkermansia to advanced applications in dietary practices and healthcare Today's Topics: • What is Akkermansia? (00:00 - 17:38) • Why are polyphenols necessary for Akkermansia to work optimally? (17:38 - 20:16) • What causes low levels of Akkermansia in the gut and what are the symptoms? (20:16 - 25:25) • Benefits of Akkermansia supplementation and optimizing Akkermansia (25:25 - 28:51) • Is there a difference between pasteurized and live Akkermansia supplements? (28:51 - 35:41) • Pendulum's New Akkermansia Supplements: Metabolic Daily and GLP-1 Probiotic (35:41 - 46:54) As always, thanks for tuning in! *****Learn More about Akkermansia and Pendulum Therapeutics: https://pendulumlife.com/ *****Click here to subscribe to my channel: https://www.youtube.com/channel/UCM2Jjqb7MqtZ7VDIuRjguLA/?sub_confirmation=1     *****Connect with me on Instagram: https://www.instagram.com/doctorjones_doctorjones/     *****Connect on Facebook: https://www.facebook.com/GregJonesNMD

In this episode, Dr. Colleen Cutcliffe explores antibiotic effects on gut microbiome, Akkermansia, GLP-1 stimulation, and implications of gut-brain communication on neurological disorders like Parkinson's and Alzheimer's. They dive into: 1. The evolution of antibiotics 2. The recent discovery of the keystone probiotic strain Akkermansia 3. Akkermansia's benefits 4. How neurons in the gut communicate with the brain Dr. Colleen Cutcliffe, Cofounder and CEO of Pendulum Therapeutics, is leading a dedicated team in their pursuit of groundbreaking and transformative solutions for gut health-related ailments, showcasing a remarkable passion for improving people's lives through revolutionary, safe, and effective microbiome interventions. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more. We discuss: Colleen's background and current focus [4:45]; The basics of the microbiome [7:15]; The study of the human microbiome [15:15]; Categories of bacteria, and the implications on health of the rapid evolution of bacteria [19:45]; Methods for measuring and understanding the microbiome, and key indicators of microbiome health [28:30]; The important role of fiber for promoting gut health through the production of butyrate [38:30]; The case for manipulating gut bacteria via fecal microbiota transplant (FMT) [45:00]; Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function [50:15]; Factors that influence the vaginal microbiome [55:15]; The effect of gut microbes on obesity and challenges with fecal transplants in people [58:45]; Beneficial strains of gut bacteria and strains commonly found in probiotics [1:01:15]; The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” [1:09:45]; Considerations about how probiotic strains are produced, and more on the meaning of CFU [1:14:15]; Mitigating the effect of antibiotics on the microbiome [1:22:30]; What do we know about the effect of artificial sweeteners on the gut microbiome? [1:30:00]; Why Akkermansia is a keystone strain with implications for metabolic health and an individual's response to dietary interventions [1:36:15]; The essential steps necessary to develop a robust probiotic for optimal health support [1:45:45]; How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more [1:48:45]; Pendulum Therapeutics' commitment to rigorous product develop [2:06:30]; Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics [2:13:00]; Further studies of Akkermansia that have been proposed or are underway [2:20:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

What happens to your gut health when you take antibiotics?   In this episode of the Biohacking Superhuman Performance podcast, we chat with Colleen Cutcliffe of Pendulum Life about the effects of our gut microbiome on our mental health, metabolism, energy levels, and learn to pinpoint signs of compromised gut health.   Colleen dissects the nuances of probiotics, prebiotics, postbiotics, and synbiotics, and how these elements interact in our gut. Additionally, we examine the often-underestimated impact of antibiotics on our microbiome and how it can be combated with effective strategies.   Lastly, we shift our focus to a specific strain of bacteria, known as akkermansia, and explore their role in food metabolism and mood regulation. In the same vein, we contemplate on the potential risks of long-term drug use including GLP-1, and delve into the impact of metformin on gut health.    Colleen Cutcliffe is the CEO and Co-Founder of Pendulum Therapeutics. Colleen has over 20 years of experience managing and leading teams in biotech, pharma and academia. Prior to that, Colleen was a Scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral research at Northwestern's Children's Memorial Hospital, received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and received her B.A. in Biochemistry from Wellesley College.   Thank you to our sponsors for making this episode possible:   Healthgevity: Go to healthgev.com and use code LONGEVITY to save. Berkeley Life: Go to berkeleylife.com and use code NIDDBL to save. LVLUP: Go to lvluphealth.com and use code NAT10 for 10% off your order. Find more from Nathalie:   YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  Instagram: https://www.instagram.com/nathalieniddam/  Website: NatNiddam.com   Join Nat's Membership Community: https://www.natniddam.com/bsp-community  Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Colleen:   Website: https://pendulumlife.com/  Facebook: https://www.facebook.com/PendulumLife  Instagram: https://www.instagram.com/pendulumlifeco/  Linkedin: https://www.linkedin.com/company/pendulumco/  Twitter: https://twitter.com/Pendulum_Co  What we discuss:   (00:02) - Gut Health and Mental Health Connection (07:43) - Understanding Gut Health and Microbiome Terminology (19:16) - The Battle of Diets and Nutrition (26:37) - Antibiotics' Impact on Microbiome and Rebalancing Strategies (35:37) - Gut Microbiome and Healthy Aging (44:30) - Risks of Long-Term Antibiotic Use (58:39) - Benefits and Challenges of Akkermansia  (01:04:49) - Live Probiotics and Colonization Importance   Key takeaways:   Nutrition is an important part of gut health. However, there isn't a particular diet that will make or break your gut health nor can you eat a nutrient-poor diet and expect probiotic supplements to keep your gut microbiome in good shape. Simply aiming to eat a balanced, nutrient rich diet is the way to go. While antibiotics have a negative impact on your gut health, it does come with a plus side. Given that antibiotics eliminate all bacteria – good and bad – the timeframe following an antibiotic treatment is a great time to focus on fixing your diet so you can repopulate your gut microbiome with the appropriate strains. While many of us blame our poor willpower for our cravings, it's usually our gut microbiome that is to blame. Luckily, there are specific strains one can supplement to help increase GLP-1 and GABA production to stimulate satiety and reduce anxiety, which helps reduce cravings overall.  

"I've earned the right to evolve into somebody different," says Halle Berry. The actor joins GP to talk about what her inner dialogue sounds like at age 57 and the identity shift that comes around during the back half of life. Berry shares why she feels empowered by menopause and why her own health trajectory led her to getting involved with Pendulum Therapeutics, a company focused on metabolic health through microbiome products. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

You might've heard me say it before: "The gut is the second brain." With over two decades of leadership in biotech, pharma, and academia, my guest on today's show, Colleen Cutliffe, is gut-deep :) in microbiome knowledge. Her path, spanning from the hallowed halls of Johns Hopkins University to groundbreaking initiatives at Pacific Biosciences and Elan Pharmaceuticals, showcases an unyielding curiosity about the mysteries of the human body. Now, as the driving force behind Pendulum Therapeutics, Colleen is charting new territories in the world of the microbiome. Akkermansia muciniphila, one of Pendulum's products, is a unique oval-shaped bacterium that thrives in the human gastrointestinal tract. This anaerobic microbe predominantly resides at the junction between oxygen-rich and oxygen-depleted zones of the intestines. Found in about 90% of healthy individuals, it constitutes 1% to 3% of your fecal microbiota. However, its prevalence can decrease with age or certain diseases. In today's chat, Colleen unravels the enigma of the gut-brain axis and its monumental influence on the microbiome's functionality. She sheds light on the role of natural agents like berberine, bitter melon extract, apple cider vinegar, and even pharmaceuticals like metformin in regulating blood sugar. With insights into the importance of Akkermansia muciniphila in GLP-1 production and the captivating genetic variations within the microbiome, this conversation promises a comprehensive look at gut health like never before. Full show notes: https://bengreenfieldlife.com/pendulumpodcast Episode Sponsors: JoyMode: Want to spice things up in the bedroom and boost your sexual performance? Visit usejoymode.com/GREENFIELD or enter GREENFIELD at checkout for 20% off your first order. Hiya: Get your kids the full-body nourishment they need to grow into healthy adults. Visit hiyahealth.com/BEN for 50% off your first order. Pendulum: Metabolic Daily is a powerful multi-strain probiotic that improves your metabolism, reduces sugar cravings, and breaks down carbs more efficiently. 20% off your first month with code GREENFIELD PendulumLife.com/Greenfield. Beam Minerals: If you want to up your mineral game, give Beam Minerals a try. Go to beamminerals.com and use code BEN at checkout for 20% off your order. FUM: Stopping is something we all put off because it's hard, but switching to Füm is easy, enjoyable, and even fun. Visit tryfum.com/BEN and use code BEN for 10% off your order.See omnystudio.com/listener for privacy information.

Colleen Cutcliffe, co-founder and CEO of the groundbreaking probiotics company Pendulum Therapeutics, started the company with a big goal in mind: changing the way people think about their gut health. And on her journey, she's had to challenge traditional – and sometimes outdated – thinking from the medical community and investors. In this episode, Colleen told us how she's been able to disrupt the industry, and gives her advice for making changes in any workplace.  In this episode, Colleen shares:  How she convinced the dean of her PhD program to let her stay – despite almost getting kicked out  Why her daughter's birth inspired her to start Pendulum  How she dealt with being told “no”  The ways she's cultivated trust and transparency with her team Why she's got Halle Berry on speed dial  PS: Skimm'rs get 20% off their first month of any Pendulum product(s) with code SKIMM9TO5.

In this episode of Habits and Hustle, I chat with Colleen Cutcliffe who gives us a step-by-step guide on all things gut health – understanding why optimization is key, why it's growing in popularity, how your gut is controlling you, and exactly what you should do to reclaim your gut microbiome. We also dive into how the gut is linked to your metabolism, the popular trend of glucose control and why we should be concerned about our glucose levels, and why an increasing number of people are seeking natural alternatives to metformin. Colleen Cutcliffe is the CEO and Co-Founder of Pendulum Therapeutics. Colleen has over 20 years of experience managing and leading teams in biotech, pharma, and academia. Before starting Pendulum Therapeutics, Colleen served as the Senior Manager of Biology at Pacific Biosciences, which is where she met her two co-founders. Prior to that, Colleen was a Scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral research at Northwestern's Children's Memorial Hospital, received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and received her B.A. in Biochemistry from Wellesley College. Use code “JENCOHEN” for 20% off of your first bottle of membership at pendulumlife.com What we discuss: (0:09:01) - Akkermansia's Role in Gut Health (0:17:41) - GLP-1 and Akkermansia in Metabolism (0:31:36) - Longevity Drugs and Glucose Control (0:35:01) - Glucose Control and Metabolic Supplement Benefits (0:45:16) - Gut Health Benefits and Quality Control (0:57:15) - Understanding Acromantia and Its Benefits Thank you to our sponsors: Pendulum: Head over to www.pendulumlife.com and use code JENCOHEN for 20% off. Therasage: Head over to therasage.com and use code Be Bold for 15% off Ketone IQ (HVMN): You can save 30% off your first subscription order of Ketone-IQ at HVMN.com/JEN Find more from Jen:  Website: https://www.jennifercohen.com/ Instagram: @therealjencohen  Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Learn more from Colleen Cutcliffe: Website: https://pendulumlife.com/ Instagram: https://www.instagram.com/pendulumlifeco/ Learn more about your ad choices. Visit megaphone.fm/adchoices

I welcome back John Eid co-founder of Pendulum Therapeutics, one of my go-to companies for innovative gut health supplements. If you've been with us before, you'll remember John from our discussions on the benefits of Akkermansia, my favorite gut buddy. He's back with incredible new findings on this powerful bacteria and so much more - including GLP-1.Full show notes and transcript: https://drgundry.com/glp-1Thank you to our sponsors! Check them out: Receive an exclusive listener discount on trusted ProHealth NR supplements by heading to prohealth.com/gundry today. Timeline is offering 10% off your first order of MitoPure. Go to timelinenutrition.com/GUNDRY and use code GUNDRY to get 10% off your order.

In this podcast, Dr. Colleen Cutcliffe, a PhD scientist and the co-founder and CEO of the microbiome company, Pendulum Therapeutics, discusses the role that different bacterium such as Akkermansia play in optimal gut health and function. Click here to view episode transcript: https://www.ifm.org/news-insights/akkermansia-gut-health-with-dr-colleen-cutcliffe/

Dr. Colleen Cutcliffe, Cofounder and CEO of Pendulum Therapeutics, is leading a dedicated team in their pursuit of groundbreaking and transformative solutions for gut health-related ailments, showcasing a remarkable passion for improving people's lives through revolutionary, safe, and effective microbiome interventions. In today's episode with Dr. Colleen Cutcliffe, you'll hear us take a deep dive on: 1. The evolution of antibiotics and how their broad spectrum also harms the gut microbiome, potentially causing long-term issues like food sensitivities, chronic illnesses, and conditions beyond the digestive system, such as obesity and neurological disorders. 2. The recent discovery of the keystone probiotic strain Akkermansia, which resides in the gut lining, and its crucial role in preventing gut lining deterioration. 3. Akkermansia's benefits, including producing proteins that stimulate GLP-1, a hormone involved in regulating insulin and glucose response to prevent high glucose spikes and promote weight loss. 4. How neurons in the gut communicate with the brain, influencing cravings and other functions, and recent studies indicate that neurological conditions like Parkinson's and Alzheimer's may manifest in gut neurons before brain cells. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide Use code root20 for 20% off of your next purchase of Akkermansia - bit.ly/3p8qxkn

In this episode of the Thrive State Podcast, Dr. Kien Vuu (Doctor V) sits down with Dr. Colleen Cutcliffe, an expert in the microbiome and co-founder of Pendulum Therapeutics. They discuss the critical role of the microbiome in overall health, ways to optimize it, and the future of microbiome research. Discover practical tips and strategies for improving your gut health and overall wellbeing.   Get 20% off your first order of Pendulum with code THRIVE20.    Don't forget to follow Doctor V @doctorvmd, grab a copy of the #1 Amazon bestseller Thrive State at thrivestatebook.com, and download a free longevity guide at thriveto105.com.   Episode Highlights: Dr. Cutcliffe's journey into microbiome research The importance of the microbiome in overall health How lifestyle choices impact the microbiome Strategies for optimizing your microbiome The future of microbiome research

« Manger Bouger » pour être en bonne santé.   Quels sont les effets du sport sur le microbiote intestinal ?  Marion Leclerc, directrice scientifique à Pendulum Therapeutics est l'invitée de cet épisode.     Concept, écriture et recherche d'invités : Anne-Sophie Alvarez Écriture, réalisation et montage : Laure Caruso Mixage : Victor Audouze Production : MetaGenoPolis-INRAE, projet Le French Gut Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

#sponsoredepisodeDid you realize how much your gut microbiome influences your metabolism, your weight and your overall health? Dr. Whitney talks with Colleen Cutcliffe, PhD, CEO and Co-Founder of Pendulum Therapeutics about how the gut microbiome works, optimizing the way your body handles the nutrients you consume, and choosing a probiotic that really works. Colleen Cutcliffe, PhD, is the CEO and Co-Founder of Pendulum. She has over 15 years of experience leading and managing biology teams in academia, pharmaceuticals and biotechnology. Prior to starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.You can find out more at www.modernmommydoc.com/podcastAbout Pendulum:Pendulum optimizes the metabolism of sugar and carbohydrates, reducing sugar cravings and energy slumps, boosting sugar and carb metabolism, AND supporting a healthy weight. Pendulum understands that whole-body health and wellness is tied to the complex ecosystem of microorganisms that is the microbiome, and that addressing imbalances in the microbiome transform people's lives from the inside.Their mission is simple: to improve the lives of millions through microbiome products. To that end, they create products that have the power and efficacy of a pharmaceutical with the safety and accessibility of a probiotic.To accomplish their mission, they developed an entirely new product–a medical probiotic. Medical probiotics are the bridge between nature and medicine, helping restore our bodies to their peak balance.To learn more about Pendulum Therapeutics AND to get 20% off your first month of Pendulum membership, go to www.pendulumlife.com and use code MODERN20

Tired of persistent, unhealthy food cravings? How about belly fat that just won't budge? Well, there are two things I want you to know: Number 1: You're NOT alone. The majority of people are what we call metabolically INflexible – and are therefore not able to burn body fat for fuel. Number 2: There IS something you can do about it. Colleen Cutcliffe – the CEO and co-founder of Pendulum Therapeutics – a revolutionary gut-health supplement company joins me to discuss akkermansia, and other incredibly powerful good gut bacteria strains, to support healthy weight and overall wellness. Show notes and transcript: EP 243 - The BEST Probiotic for Metabolism? Thank you to our sponsors~ Use code GUNDRY20 for 20% off your first month of a Pendulum membership at Pendulumlife.com. Pendulum probiotics are also available on Amazon. Get your quote today at Progressive.com and join the over 29 million drivers who trust Progressive. Receive 20% off new orders of the trusted ProHealth NMN supplements or 25% off subscriptions by heading to prohealth.com/gundry today. Keep you and your family safe with the AquaTru water purifier, just go to AquaTruWater.com and use the code GUNDRY20 for 20% off any water purifier. Get convenient, high-quality, affordable groceries delivered with Thrive Market. Get $80 in free groceries at thrivemarket.com/gundrypodcastTransform your sleep experience with Cozy Earth bedding, go to cozyearth.com/gundry

In part 1 I talked about information that was brought to me by two senior residents who wanted people to know that they are being invited to “educational summits” that are actually being run by doctors with massive undisclosed ties to the pharmaceutical companies that make the drugs that are recommended in the summits. I did some digging around the company that is behind this to try to get some information about what's going on.The company that created both of these summits is PCMG, Primary Care Metabolic Group. Their tagline is “Serving to Educate Primary Care Clinicians on Metabolic Issues.” The words “Evidence Based Medicine” appear prominently in the banner at the top of each page. Their homepage states:The Primary Care Metabolic Group (PCMG) is a national educational initiative providing comprehensive metabolic disease resources. PCMG's mission is to provide an easily accessible repository of metabolic disease information for primary care clinicians that includes disease management and raising standards of patient care through the dissemination of best practices and educational information.Their ”services” include·         Monthly metabolic disease news articles from our partners·         Opportunities for FREE CME·         Member discounts for upcoming CME conferences and summitsAs a quick aside, CME stands for Continuing Medical Education. Doctors must obtain a certain number of CMEs in order to maintain their state licensure. The number of CME hours and requirements as to topics varies by state.  Full disclosure, many of the workshops/talks I give for physicians provide CMEs. None, as far as I know, has ever been sponsored by a pharmaceutical company and I don't receive any money from the pharmaceutical industry.Back to PCMG. The word “partners” struck me in the first bullet point. What do they mean by “partners?” As I scrolled down the page I see that they are welcoming a new “collaborator” – the Ob*sity Action Coalition. It says “This national nonprofit coalition is fighting to eliminate weight bias and discrimination, elevating the conversation of weight and its impacts on health, and offering a community of support to people affected. OAC also offers resources for clinicians, as well as a database of clinicians who treat patients with ob*sity.”It doesn't say that this “national nonprofit coalition” has Novo Nordisk (manufacturer of the weight loss drug Wegovy and one of the leading pharma companies price gouging on insulin) as its main funder, with the vast majority of its funding coming from pharmaceutical companies and weight loss surgery interests. It doesn't say that their plan to “eliminate weight bias” is focused on pushing for insurance coverage of their dangerous drugs and surgeries, or that they are trying to sell the “we don't want to stigmatize fat people, we just want to make as much money as we can trying to eradicate them from the earth” line that is not, in any way, an anti-stigma approach.After reading the entire website, I called PCMG to ask what they meant by “partners” as well as who was funding the free and discounted CME training.I spoke with Nora Williams. I opened by explaining that I was writing an article about CME trainings and I had a couple quick questions about how their trainings were structured. She interrupted me to say that she was “suspicious” because she didn't know who I was, or what outlet I was writing for, or what my story was about (in my defense, she hadn't let me get that far.) She told me that if I sent her an email she would “consider it.” For me, this has the ring of a company that knows they are involved in things that they would rather not have brought to light, but of course, that's just my gut feeling. I emailed her after our call in the afternoon of 1/7/23 and am still awaiting a response.However, the email that she gave me led me to PCEConsortium.orgIn searching, I had already found Primary Care Respiratory Group – US (PCRG) which has a website that is almost an exact copy of PCMG, except replacing metabolic with respiratory. The Consortium site has a long list of free CME workshops.I wanted to look into their materials, so I started by downloading their free CME “Common Questions on Continuous Glucose Monitoring (CGM) in Primary Care” I am not an expert in CGM, but I do a lot of work around weight-neutral blood sugar management and so it's an area where I felt confident that I had enough knowledge to understand the paper.The author is Eden Miller, DO (who you may recognize as having been a speaker at both the free summits and having taken $1,429,227.40 in industry payments.) Miller is the co-founder and CEO of Diabetes Nation - Diabetes and Ob*sity Care, and in this publication disclosed that she serves on the advisory board and speakers bureau for Abbott Diabetes, Boehringer Ingelheim, Eli Lilly, and Novo Nordisk; on the advisory board for AstraZeneca, Merck, Plenity, and Sanofi Aventis; and does research for Abbott Diabetes and Pendulum Pharmaceuticals.Here are some things that I noticed:Two of the devices that the paper specifically mentions are made by Abbot Laboratories (for whom Miller is a speakers bureau member and does research.)In the section “Which patients will benefit from its use” Miller (who, again, takes money from a CGM device manufacturer) writes “This author does not feel there are any poor candidates for CGM as all people with diabetes could benefit on some level from the data and insight it provides.”That struck me as odd. Again, I'm not an expert but it would be…surprising… if this device wasn't contraindicated for anyone. A quick search of Abbott's website (remember this is a company for which Dr. Miller does research and is on the speakers bureau) explains that you “should not use the [CGM] system” for people less than 18 years of age, critically ill patients, pregnant women or patients on dialysis,  and that the system has not been evaluated on patients who use other implanted devices. Other studies and articles mention things like technology aversion, medications that interfere with CGM, certain mental health diagnoses, patient motivation, and other contraindications.So, there are, in fact, poor candidates for CGM. I would suggest that this is a problem whether Dr. Miller was ignorant of this or purposely left it out. Remember, this is Continuing Medical Education – doctors are supposed to be able to rely on this information in their practice, so telling them that there aren't any poor candidates, when there very much are is a failure of that education and a danger to patients.There is a section for “Key elements to obtaining Medicare, Medicaid and private insurance,” complete with billing codes. It also mentions that “In a recent comparison of retail costs, Abbott's FreeStyle Libre had the lowest monthly cost…”The conclusion states “CGM is quickly emerging as a standard of care for many patients with diabetes.”To back this statement up, Miller cites a study by John B. Welsh, PhD and Roy Thomas, PharmD. A quick look at the disclosures for that study finds that both are employees of Dexcom, the manufacturer of the Dexcom G6 Continuous Glucose Monitor.You have to wonder: To what extent is this CME providing evidence-based information, and to what extent is this simply an extension of Dr. Miller's duties as a member of Abbott's Speakers Bureau?But maybe this one was just a fluke, right? While I was waiting on the reply from Nora that never came, I took a quick look at some of the other free CME on the consortium's page. I definitely found a pattern of CME that was recommending products that were part of the author's disclosures. A couple of quick examples:Title: Improving Detection and Management of Anemia in CKDAuthors: Steven Fishbane, MD; Stephen Brunton, MD, FAAFPDisclosures: Dr. Fishbane: Consultant and does research for Akebia and AstraZenec aand is a consultant for FibroGen and GlaxoSmithKline.Dr. Brunton:  Advisory board and speakers bureau for Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, and Sanofi, and on the advisory board for Xeris and Pendulum Therapeutics.Summary: “HIF-PHIs are investigational agents on the horizon that, if approved, will offer patients an oral option to treat anemia in CKD”A quick search found that AstraZeneca, GlaxoSmithKline, and Akebia are all developing HIF-PHIs.Title: The Role of Eggs in Healthy DietsAuthor: Maria Luz Fernandez, PhDKey takeaways: Eggs can be part of a healthy diet, Epidemiologic evidence and clinical trials have found no links between egg intake and increased risk for heart disease, Eggs are a good source of high-quality protein, Eggs, in addition to numerous vitamins and minerals, contain compounds including choline, lutein, and zeaxanthin with functions that go beyond nutrition as they protect against chronic disease.Disclosure: Dr. Fernandez has a research grant from The American Egg Board.Sponsorship: “This [CME] activity is sponsored by Primary Care Education Consortium and supported by funding from The American Egg Board.”There is language in some of PCMG's CMEs (though, interestingly, not in the egg-related CME) that claims that conflicts of interest have been “mitigated,” but is that even truly possible?Regardless of how ethical the authors might be, there are undeniable conflicts of interest when those who are creating education about pharmaceuticals are also paid advocates for those pharmaceutical companies.At some point, simply disclosing affiliations is not enough. I believe that we are, in fact, way past that point. There is literally nothing to prevent the pharmaceutical industry (not to mention weight loss surgery interests, medical device manufacturers, etc.) from simply putting a stable of doctors on their payroll and letting them use their credentials as the ultimate sales tools, including by engaging with companies that convert pharmaceutical industry marketing messages into CMEs that are delivered to doctors and other healthcare practitioners who think that they are getting education about best practices and educational information. It's similar to what we've seen in the media and it is a dangerous disservice to healthcare practitioners and patients.I want to, again, give thanks and credit to Dr. Clarissa O'Conor and Dr. Will Ward, who originally reached out to me, for all of the work they did researching this. They are in the middle of intense training and still finding the time to do extra work to try to get the education (free from pharma industry influence,) that they deserve.And we should all have their backs - asking questions, doing research, pointing out these flagrant conflicts of interest and dirty diet industry tactics. Our doctors deserve the best education they can get, not the best education pharmaceutical companies can buy.Did you find this post helpful? You can subscribe for free to get future posts delivered direct to your inbox, or choose a paid subscription to support the newsletter and get special benefits! Click the Subscribe button below for details:More research and resources:https://haeshealthsheets.com/resources/*Note on language: I use “fat” as a neutral descriptor as used by the fat activist community, I use “ob*se” and “overw*ight” to acknowledge that these are terms that were created to medicalize and pathologize fat bodies, with roots in racism and specifically anti-Blackness. Please read Sabrina Strings Fearing the Black Body – the Racial Origins of Fat Phobia and Da'Shaun Harrison Belly of the Beast: The Politics of Anti-Fatness as Anti-Blackness for more on this.Note I don't link to everything I discuss in this post because I don't want to give traffic and clicks to dangerous media. Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

Colleen Cutcliffe, PhD, joins Integrative Practitioner associate editor, Avery St. Onge, to discuss how probiotics with targeted keystone strains like Akkermansia muciniphila can help restore optimal function to the gut microbiome and improve overall health. This episode is sponsored by Pendulum Therapeutics. Find us at integrativepractitioner.com or e-mail us at IPEditor@divcom.com. Theme music: “Upbeat Party” by Scott Holmes via freemusicarchive.org and “Carefree” by Kevin Mcleod via incompetech.com.

This week's conversation is with Dr. Colleen Cutcliffe, the CEO and Co-Founder of Pendulum Therapeutics.Colleen's extensive background includes a doctorate in Biochemistry and Molecular Biology from Johns Hopkins University, and over 20 years of experience managing and leading teams in biotech, pharma, and academia.In 2013, Colleen left her position as Senior Manager of Biology at Pacific Biosciences to start Pendulum, a company on a mission to improve health through first of its kind research and development in the gut microbiome.Pendulum's next generation probiotics are pioneering ways for people to transform their health and wellness by unlocking the power of the gut microbiome.I've been studying gut health and the microbiome for a long time now, and it's clear that Pendulum is on the forefront of creating meaningful change for people.I was fascinated to learn more about the topic from Colleen, and I hope you leave this conversation with a better understanding of the gut microbiome, and some applied insights on how improving your gut health can improve your life.-----Please support our partners!We're able to keep growing and creating content for YOU because of their support. We believe in their mission and would appreciate you supporting them in return!!To take advantage of deals from our partners, head to http://www.findingmastery.net/partners where you'll find all discount links and codes mentioned in the podcast.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Colleen Cutcliffe, CEO and Co-Founder of Pendulum Therapeutics, joins Chris on this episode of Revolution Health Radio to discuss how metabolic health is related to the gut microbiome, microbiome research, and probiotics. They'll talk about the problem with current probiotics, the opportunities being presented by novel strains and formulations, innovations in understanding the gut–metabolic and gut–brain connections, and the challenges of bringing anaerobic probiotics to the marketplace. The post RHR: The Microbiome Approach to Better Probiotics, with Colleen Cutcliffe appeared first on Chris Kresser.

Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF

Roelof Botha — Investing with the Best, Ulysses Pacts, The Magic of Founder-Problem Fit, How to Use Pre-Mortems and Pre-Parades, Learning from Crucible Moments, and Daring to Dream | Brought to you by Wealthfront's high-yield savings account, Eight Sleep's Pod Cover sleeping solution for dynamic cooling and heating, and Shopify global commerce platform providing tools to start, grow, market, and manage a retail business. More on all three below.Roelof Botha (@roelofbotha) has spent over 20 years building companies in Silicon Valley. He began within the walls of nascent PayPal, which he joined in March of 2000 while completing his MBA at Stanford. He became CFO in 2001 and led the company through both its IPO in early 2002 and subsequent acquisition by eBay. Roelof joined Sequoia Capital in 2003 to help founders build enduring businesses. He leads the US/Europe business as Managing Partner and serves as Senior Steward of the global Sequoia Partnership. Roelof is a director of 23andMe, Bird, Ethos, Evernote, Inside.com, Landis, mmhmm, MongoDB, Natera, Pendulum Therapeutics, Square, and Unity Technologies. Previously, he was a director of companies that include YouTube, Tumblr, Xoom, Assurex, and Eventbrite. He also led Sequoia's investment in Instagram.Please enjoy!This episode is brought to you by Wealthfront! Wealthfront is an app that helps you save and invest your money. Right now, you can earn two percent APY—that's the Annual Percentage Yield—with the Wealthfront Cash Account. That's twenty times more interest than if you left your money in a savings account at the average bank, according to FDIC.gov. It takes just a few minutes to sign up, and then you'll immediately start earning two-percent interest on your savings. And when you open an account today, you'll get an extra fifty dollar bonus with a deposit of five hundred dollars or more. Visit Wealthfront.com/Tim to get started.*This episode is also brought to you by Shopify! Shopify is one of my favorite platforms and one of my favorite companies. Shopify is a platform designed for anyone to sell anywhere, giving entrepreneurs the resources once reserved for big business. In no time flat, you can have a great looking online store that brings your ideas to life, and you can have the tools to manage your day-to-day and drive sales. No coding or design experience required.More than a store, Shopify grows with you, and they never stop innovating, providing more and more tools to make your business better and your life easier. Go to Shopify.com/tim for a FREE 14-day trial and get full access to Shopify's entire suite of features.*This episode is also brought to you by Eight Sleep! Eight Sleep's Pod Cover is the easiest and fastest way to sleep at the perfect temperature. It pairs dynamic cooling and heating with biometric tracking to offer the most advanced (and user-friendly) solution on the market. Simply add the Pod Cover to your current mattress and start sleeping as cool as 55°F or as hot as 110°F. It also splits your bed in half, so your partner can choose a totally different temperature.And now, my dear listeners—that's you—can get $250 off the Pod Cover. Simply go to EightSleep.com/Tim or use code TIM at checkout. *For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Dr. Jeffery Gladden speaks with Colleen Cutcliffe, Ph.D., the Co-founder and CEO of Pendulum Therapeutics, she has an impressive background in leading and managing biology teams. She's a scientist with a Ph.D. in Biochemistry and Microbiology from Johns Hopkins University and has held senior positions at bioscience and pharmaceutical firms. Pendulum is passionate about finding revolutionary, safe, and practical solutions to ailments that can be tied to your gut, and they have a goal to bridge nature and medicine. In this episode, they talk about probiotics and what led Colleen down this particular path. They mention that there are critical pathways in our microbiome that need to be operational: fiber→, butyrate + mucin regulation. They also talk about Pendulum and the benefits of the products they offer, and how the ability to manage glucose response is fundamental to healthy aging.    Dr. Gladden introduces Colleen, and she introduces herself and how she got into what she does now. (1:30) Colleen talks about how you could approach the microbiome using DNA sequencing data science. She also mentions that if you could marry DNA sequencing technologies and network data science with pharmaceutical drug development, you could, with the microbiome, create products that had the efficacy of a drug but the safety of a probiotic. (2:40) Colleen mentioned a study that showed kids taking antibiotics before six months of age were also systematically more prone to obesity and type two diabetes as they age. Dr. Gladden mentions how antibiotics affect children. (4:00) Colleen mentions how butyrate is a small molecule that's been known for quite some time to have a really important role in a variety of different things. She says it is probably one of the most interesting things is that in our colon, our colon cells are the only cells in our entire body that use butyrate as their source of energy as opposed to glucose. (6:10) Dr. Gladden mentions how the fiber metabolism generates butyrate that feeds the intestinal lining. Dr. Gladden also mentions how fascinating it is that the butyrate is responsible for releasing GLP-1. (7:30) Colleen notes that if you are missing your microbiomes, ingesting fiber does not make much difference. (10:00) Dr. Gladden mentions some misconceptions about microbiomes and always compares the person's stool  against an "ideal" stool. (11:59) Dr. Gladden talks about keystone strains and how what we are eating affects and influences them and the importance of eating different kinds of fibers. (14:00) Colleen talks about a study they did telling people to keep doing what they are doing and seeing a way to influence the microbiome and then have this impact on A1C and blood glucose. (17:00) Dr. Gladden talks about how microbiomes also affect appetites and that the microbiomes you grow affect what you crave. (19:00) Colleen mentions that the formulation is stable but needs to be refrigerated. She also mentions the five strains - Akkermansia muciniphila, Anaerobutyricum hallii, Bifidobacterium infantis, Clostridium butyricum, and Clostridium beijerinckii. (21:10) Colleen mentions some of the trials they have done and the approach they adopted. (24:10) Dr. Gladden talks about neuroinflammation and if Pendulum decreases neuroinflammation. (27:04) Colleen mentions that there is a known relationship between managing your blood glucose spikes and neural inflammation. (28:05) Dr. Gladden mentions what resting metabolic rate is and how it is measured. (32:44) Colleen says that if you have not had diversity in your diet, you may not have all the microbiomes you need to metabolize some food. She also talks about the regulation of mucin, which is the glue that keeps everything properly in place. (35:34) Colleen talks about what is on the drawing board for her at the moment. (39:15) Dr. Gladden talks about the connection between autism and microbiomes. (41:30) Collen talks about also looking out for and considering microbiomes as something additional in our intervention efforts. (43:25) Colleen gives out three takeaways for listeners. She mentions that food diversification is important to diversify our microbiome. The second thing is knowing that regulating how your body metabolizes sugar is important to healthy aging. Lastly, if you want to give yourself a boost to your microbiome, try the Pendulum glucose control strains paired with the proper diet. (45:39) Collen mentions the importance of people consulting their physicians when making changes that could affect their health. (48:00)   Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today!     Website: Learn more about the next generation of gut health by visiting www.pendulumlife.com  Instagram: @pendulumlifeco TikTok: pendulumlife Facebook: https://www.facebook.com/PendulumLife/ (For Gladden Longevity listeners, use code GL20 to subscribe and save 20% on your first month of Pendulum's subscription products.)

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Capture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewideSkin Health and Healing: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSPECIAL OFFER FOR LISTENERS OF THE HUMAN UPGRADE: Go to https://pendulumlife.com and use promo code "DAVEVIP" to get an exclusive discount.IN THIS EPISODE OF THE HUMAN UPGRADE™...…you'll learn about emerging science that points to the effects of sugar on your gut microbiome and metabolism and the connections between sugar, your mental acuity and longevity.Biochemist and molecular biologist Colleen Cutcliffe, Ph.D., continually searches for new ways to improve your gut health and help you live longer. As CEO and co-founder of Pendulum Therapeutics, she works to turn scientific discoveries into real products that hack and heal your microbiome and its associated body systems. At Pendulum, her team identifies and isolates new bacterial strains then combines those new strains to create unique probiotics.“We really worked hard on ways to modulate post-postprandial glucose spikes through the microbiome,” Colleen says. The result? Pendulum's Glucose Control lowers blood glucose spikes by 33 to 34% for people with type 2 diabetes. “What we didn't realize was how many people who don't have type 2 diabetes were going to end up benefiting from it.”This conversation homes in on sugar management and a broad range of research that's exploring what you can do about managing your glucose to keep up your mental acuity (less brain fog, sharper thinking) and live a longer life. Science has discovered that as you age:You have reduced ability to metabolize sugar. Your microbiomes become less diverse and depleted of certain key strains that are important for sugar metabolism.If you improve glucose control, you see reduced neuronal inflammation and improved cognition.In the past decade, especially, sugar dominates a lot of the conversation around diet and health. It's been studied, substituted, moderated, restricted and demonized. With that type of focus, you lose the bigger point. “You can't completely cut out sugar,” Colleen says. “You do need sugar. Not all sugar is bad for you all the time. Every cell in your body, except for your colon cells, need glucose in order to survive, in order to replicate, in order to perform functions. All of the things that allow you to be a human being require some amount of sugar."She wants you to know what's happening to cause the change in metabolic processing as you age and what you can do about it, like:How to understand your blood glucose range and what fluctuations mean.How to track your blood glucose and what to do about peaks and dips.How to improve your focus, sharpness and mental endurance through diet and fitness.“I'm a scientist, so I'm always going to say more data is better,” Colleen explains. “[Especially] when you're trying to make improvements and you're making these micro-adjustments in your life, and you want to understand what impact are they having.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Researchers continue to explore and build on existing knowledge regarding the role of the gut microbiome and food choices in the pathophysiology and management of numerous chronic diseases, including type 2 diabetes, cardiovascular diseases, gastrointestinal disorders, and even mental health disorders. This episode addresses the impact of food choices in shaping the gut microbiome, including what nutrients feed the gut microbiome, and the current science on the gut microbiome's impact on health outcomes and disease. Guests on this show include a renowned endocrinologist who has spent his career in diabetes care and research focused on the role of the gut in diabetes management, and a registered dietitian nutritionist and certified diabetes care and education specialist who is well versed in this science, nutrition management and the use of probiotics. Tune in to this episode to learn about: the gut microbiome's impact on various chronic diseases the impact of proper nutrition in shaping the gut microbiome, and subsequently overall health what nutrients support a healthy gut microbiome definitions of prebiotic, probiotic, postbiotic, synbiotic, short-chain fatty acids and butyrate current research study designs and objectives as well as findings from completed research studies regarding the role of the gut microbiome and chronic diseases the importance of learning how to nurture the gut microbiome through food choices and dietary supplements an update on new products and services offered by the registered dietitian nutritionists at Pendulum Therapeutics   This episode is sponsored by Pendulum Therapeutics, a company that applies evidence-based microbiome science and DNA sequencing to develop a new generation of probiotics. This episode has been submitted to CDR for continuing education credits for RDNs, DTRs and CDCESs. Full shownotes and resources at: https://soundbitesrd.com/212     

In this episode, I talk with Colleen Cutcliffe, PhD, CEO and Co-Founder of Pendulum Therapeutics, a microbiome solutions company based in San Francisco, CA. Pendulum has developed two live microbial therapies, Pendulum Glucose Control for the management of type II diabetes, and Pendulum Akkermansia for the support of gut health. Dr. Cutcliffe has over 20 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. She received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University, and her B.A. in Biochemistry from Wellesley College. In our conversation we discuss a number of questions related to live microbial therapies and next generation probiotics, including the following: · How did Pendulum get into the business of live microbial therapies? · How effective is this Pendulum Glucose Control for the treatment of type II diabetes, and what is the evidence? · For which patients is Glucose control indicated? · What is the evidence for the effectiveness of Pendulum Akkermansia for gut health? · How do you assess gut health? · How do you see the future of next generation probiotics in the treatment of chronic medical disorders? If you'd like to learn more about Pendulum's products, you can use my affiliate link here & if you buy a membership, you can take 20% off with code: EMERAN. As always, if you have any questions or comments, leave them below, and if you're enjoying our content, please take a second to like the video! Follow Dr. Mayer: https://linktr.ee/emayer

In this episode, I talk with Colleen Cutcliffe, PhD, CEO and Co-Founder of Pendulum Therapeutics, a microbiome solutions company based in San Francisco, CA. Pendulum has developed two live microbial therapies, Pendulum Glucose Control for the management of type II diabetes, and Pendulum Akkermansia for the support of gut health. Dr. Cutcliffe has over 20 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. She received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University, and her B.A. in Biochemistry from Wellesley College. In our conversation we discuss a number of questions related to live microbial therapies and next generation probiotics, including the following: · How did Pendulum get into the business of live microbial therapies? · How effective is this Pendulum Glucose Control for the treatment of type II diabetes, and what is the evidence? · For which patients is Glucose control indicated? · What is the evidence for the effectiveness of Pendulum Akkermansia for gut health? · How do you assess gut health? · How do you see the future of next generation probiotics in the treatment of chronic medical disorders? If you'd like to learn more about Pendulum's products, you can use my affiliate link here & if you buy a membership, you can take 20% off with code: EMERAN. As always, if you have any questions or comments, leave them below, and if you're enjoying our content, please take a second to like the video! Follow Dr. Mayer: https://linktr.ee/emayer

Colleen Cutcliffe, co-founder and CEO of Pendulum Therapeutics, is leading the charge on helping humanity live better, healthier, and longer lives. She does this through her study of the microbiome – what other scientists and doctors now know drives nearly every avenue of our bodies (think: cognition, aging, metabolism,  Alzheimer's and Parkinson's). By creating a product that has the efficacy of a drug but safety of a probiotic, Pendulum Therapeutics has become the next generation health company with an entirely new thing – a medical probiotic. Pendulum is backed by Mayo Clinic, Meritech Capital, Sequoia Capital, Khosla Ventures and True Ventures, to name a few. Colleen's impressive background includes a Ph.D. in Biochemistry and Microbiology from Johns Hopkins University, but she shares that her role as a mother is what ultimately led her to co-found Pendulum Therapeutics. Listen in to hear Colleen's favorite sports moment (her bit on sports is phenomenal!), to learn what “leaky gut” is and how to fix it, and how to discover if you are aging healthy or not.

Ben Greenfield shares why you're wasting your time doing only long, slow aerobic workouts. Episode 1563: Why You're Wasting Your Time Doing Only Long, Slow Aerobic Workouts by Ben Greenfield on Exercising Smart Author of the New York Times Bestseller, Beyond Training, Ben Greenfield's balanced approach to fitness, nutrition and health comes from his extensive experience in the fitness and wellness industry as one of the country's leading personal trainers and wellness consultants. In 2008, Ben was nominated by the NSCA as America's top personal trainer, and in 2013 and 2014, Ben was voted as one of the top 100 most influential individuals in health and fitness. A frequent contributor to health and wellness publications and a highly sought after speaker, Ben's understanding of functional exercise, nutrition, and the delicate balance between performance and health has helped thousands of people around the world achieve their goals and improve their quality of life. The original post is located here: https://bengreenfieldfitness.com/article/fitness-articles/why-youre-wasting-your-time-doing-only-long-slow-aerobic-workouts/ Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Ben Greenfield shares why you're wasting your time doing only long, slow aerobic workouts. Episode 1563: Why You're Wasting Your Time Doing Only Long, Slow Aerobic Workouts by Ben Greenfield on Exercising Smart Author of the New York Times Bestseller, Beyond Training, Ben Greenfield's balanced approach to fitness, nutrition and health comes from his extensive experience in the fitness and wellness industry as one of the country's leading personal trainers and wellness consultants. In 2008, Ben was nominated by the NSCA as America's top personal trainer, and in 2013 and 2014, Ben was voted as one of the top 100 most influential individuals in health and fitness. A frequent contributor to health and wellness publications and a highly sought after speaker, Ben's understanding of functional exercise, nutrition, and the delicate balance between performance and health has helped thousands of people around the world achieve their goals and improve their quality of life. The original post is located here: https://bengreenfieldfitness.com/article/fitness-articles/why-youre-wasting-your-time-doing-only-long-slow-aerobic-workouts/ Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Melani Schweder of A Brighter Wild talks about how going sober is a radical act of self-love Episode 1562: Going Sober: A Radical Act Of Self-Love by Melani Schweder of A Brighter Wild on Sobriety & Alcohol-Free Lifestyle Melani Schweder is a Certified Health Coach, Reiki Master/Teacher, and guide for those who want to live life in full color, even through hardships like chronic illness, divorce, or other struggle. Her own health issues led her to dig deep into alternative/natural health and take sustainable, self-guided steps towards recovery. She is passionate about holistic methods, and her unique coaching process combines the best of her knowledge in whole-foods nutrition, Reiki, mindfulness, herbal medicine, and positive psychology. The original post is located here: https://www.abrighterwild.com/blog/going-sober-a-radical-act-of-self-love  Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Crystal Karges talks about how to live a non-diet life in a diet culture Episode 1560: How to Live a Non-Diet Life in a Diet Culture by Crystal Karges on Mental Health & Healthy Living Crystal Karges is a Registered Dietitian Nutritionist and mama of five specializing in intuitive eating for mothers and families. She's passionately committed to helping you and your children enjoy freedom with food as a family. She helps overwhelmed mamas ditch diet culture for good and heal their relationships with food and their bodies so they can confidently raise intuitive eaters and enjoy eating together as a family again. Because when mothers thrive, families flourish. The original post is located here: https://www.crystalkarges.com/blog/how-to-live-a-non-diet-life-in-a-diet-culture  Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Jenny Brockis talks about why mental wellbeing starts with putting your trainers on Episode 1559: Why Mental Wellbeing Starts With Putting Your Trainers On by Dr. Jenny Brockis on Exercise for Healthy Lifestyle Dr. Jenny Brockis is a medical practitioner and board-certified lifestyle medicine physician, keynote speaker and best-selling author based out of Perth, Western Australia. She is an expert in the science of high-performance thinking, creating thriving teams and leaders through improving brain health and wellbeing. And in her new book, Thriving Mind: How to Cultivate a Good Life, she reveals how to cultivate the mental agility, flexibility and adaptability required to meet the needs of the modern workplace and thrive. The original post is located here: https://www.drjennybrockis.com/2016/10/17/why-mental-wellbeing-starts-with-putting-your-trainers-on/ InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Jenny Brockis talks about why mental wellbeing starts with putting your trainers on Episode 1559: Why Mental Wellbeing Starts With Putting Your Trainers On by Dr. Jenny Brockis on Exercise for Healthy Lifestyle Dr. Jenny Brockis is a medical practitioner and board-certified lifestyle medicine physician, keynote speaker and best-selling author based out of Perth, Western Australia. She is an expert in the science of high-performance thinking, creating thriving teams and leaders through improving brain health and wellbeing. And in her new book, Thriving Mind: How to Cultivate a Good Life, she reveals how to cultivate the mental agility, flexibility and adaptability required to meet the needs of the modern workplace and thrive. The original post is located here: https://www.drjennybrockis.com/2016/10/17/why-mental-wellbeing-starts-with-putting-your-trainers-on/ InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Joshua Becker of Becoming Minimalist offers a loving nudge toward healthier habits Episode 1558: A Loving Nudge Toward Healthier Habits by Joshua Becker of Becoming Minimalist on Healthy Habit Formation Joshua Becker and his family decided to live with fewer possessions after a conversation with his neighbor in 2008. As a result, they found a better way to live, centered on more important pursuits. Their story has been seen on the CBS Evening News, NPR, the Boston Globe, the Wall Street Journal and countless media interviews around the world. Their books have sold in the tens of thousands. BecomingMinimalist.com is about their journey towards a rational approach to minimalism. It is about the joys and the struggles. It is about the lessons they have learned. It has inspired millions around the world. It is written to inspire you to intentionally live with less, and find more life because of it. Support The Hope Effect for Giving Tuesday: https://www.hopeeffect.com/givingtuesday2021 The original post is located here: https://www.becomingminimalist.com/healthy-habits-during-pandemic/  Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

Dani Williamson of YOUR Williamson shares her six steps to healing Episode 1557: Dani's Six Steps to Healing by Dani Williamson on Simple Ways to Feel Better YOUR Williamson is a community magazine reflecting the unique fabric and story of Williamson County, Tennessee. As a Distinctively Southern Place, YOUR Williamson tells the story of the places and people that make our community a home.  The magazine is printed on high-quality stock with a newsstand gloss and sized appropriately to a high-end lifestyle publication reminiscent of Town & Country and Garden & Gun. It is distributed throughout the county in over 300 monthly rack locations as well as in all major grocery stores. Other major distribution focuses on Davidson and Maury counties as well as the Gulf Coast of Florida. YOUR Williamson is part of the family of publications, produced by local Williamson County company, Robertson Media Group and includes: YOUR Sumner magazine and Distinctively Southern Wedding. Look for future YOUR Community Magazines publications in the works and coming soon to YOUR community! Dani's book can be found here: https://www.amazon.com/Wild-Well-Commonsense-Radical-Healing-ebook/ The original post is located here: https://www.yourwilliamson.com/article/555/danis-six-steps-to-healing  Pendulum Therapeutics is the first and only biotech company to isolate an important beneficial bacterial strain and put that strain into a convenient new probiotic-rich capsule that is formulated to help manage Type 2 diabetes and nurture your body's microbiome. Use code OHD at Pendulumlife.com to get 20% off all products InsideTracker's patented algorithm analyzes your biometric data and offers you a clearer picture than you've ever had before of what's going on inside your body. For a limited time, get 25 percent OFF the entire InsideTracker store! Go to InsideTracker.com/OHD to get your discount code and to start using InsideTracker today. Visit Me Online at OLDPodcast.com  Interested in advertising on the show? Visit https://www.advertisecast.com/OptimalHealthDailyDietNutritionFitness Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode I'm joined by Colleen Cutcliffe – the CEO and co-founder of Pendulum Therapeutics. Colleen and I reveal one of the most exciting discoveries in the history of microbiome research – akkermansia — and share how it could help YOU live a longer, healthier life. Full transcript and show notes: https://drgundry.com/Pendulum-Probiotics *This episode is sponsored by Pendulum Life - however, my opinions on Akkermansia muciniphila are my own. Thank you to our sponsors! Check them out: Get 15% off your order at TenThousand.cc and enter code GUNDRY. Just go to DrinkLMNT.com/GUNDRY for your FREE Sample. To save some bucks today on prescriptions, Go to GoodRX.com/GUNDRY. Go to www.naturenatesllc.com or Amazon and use the promo code DRGUNDRY to get 15% off your first order. Visit ThriveMarket.com/GUNDRYpodcast to start your risk-free membership and get your FREE gift and $20 discount today.

James Bullard, CTO at Pendulum Therapeutics (formerly Whole Biome), sitsdown with TDS to talk about the use of technical tools in different companies and industries.James Bullardhttps://www.linkedin.com/in/james-bullard-a2960a61/The Data Standardhttps://datastandard.io/https://www.linkedin.com/company/the-data-standard/ https://www.youtube.com/channel/UCTuolowXD05RY9DkIWqRT6Q

James Bullard, CTO at Pendulum Therapeutics (formerly Whole Biome), sits down with TDS to talk about the use of technical tools in different companies and industries.James Bullardhttps://www.linkedin.com/in/james-bullard-a2960a61/ The Data Standardhttps://datastandard.io/https://www.linkedin.com/company/the-data-standard/

Colleen is a scientist with dual doctorates in biochemistry and molecular biology AND microbiome expert about healing oneself through the gut. She received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and is the co-founder of Pendulum Therapeutics. * About The Immunity Docuseries: Never has it been so critical and obvious that our health and immunity have to be a top priority. It's now up to us to make a choice: continue down a path of disease or do everything possible be to be at our peak health. Some of the questions explored in this series include: How can we be resilient to diseases and viruses to come? What actions can we take today to achieve peak immunity? What are the non-negotiables to building immunity? * This podcast wouldn't be possible without the support of Thrive Performance & Regenerative Medicine. A team prepared to go all-in with you to craft a personalized health plan to achieve your peak health. Book a free consult to start your health transformation at - https://thrivemedicineclinic.com/ * Thrive Medicine - @thrivemedicine Dr. Rhet Langley - @rhetmd Dr. Phillip Gallegos - @phillipgallegos_md Marc Champagne - @mchampagne

Use Code: MOLLIE10 – for 10% off the first bottle of a subscription order. BIO:Colleen Cutcliffe, Ph.D., is co-founder and CEO of Pendulum Therapeutics, a biotech startup in San Francisco. The company's mission is to fill the chasm that exists between unregulated supplements and prescription drugs. In this middle ground, Colleen envisions a future in which medicines are derived not from chemistry but one of nature's greatest gifts: the human body's microbiome.The safety and effectiveness of the company's first microbiome-bolstering probiotic, Pendulum Glucose Control, is welcome news for more than 120 million Americans living with diabetes and prediabetes, struggling to control their blood sugar.Colleen's pursuit is personal. Her daughter was born nearly eight weeks premature, spending the first month of life hooked up to machines. Doctors loaded her up with antibiotics, which is the standard, often lifesaving, a protocol for preemies. But the antibiotics wreak havoc on babies' microbiomes and could result in chronic conditions as adults [source]. Now 12 years old, Colleen's daughter already suffers from gut issues and food sensitivities that no one else in the family has.There has to be a better way – therapies that spare the microbiome while treating chronic conditions – and Colleen is determined to forge a new path. Prominent Silicon Valley venture capital firms are keen to help her: Sequoia Capital, True Ventures, and Khosla Ventures have invested $57 million since 2014.Colleen received a Ph.D. in biochemistry and molecular biology from Johns Hopkins University and a B.S. in biochemistry from Wellesley College. She completed her postdoctoral research at Northwestern Medicine's Lurie Children's Hospital of Chicago. Colleen lives in Menlo Park, Calif., with her husband, two daughters, and two rambunctious dogs.LINKS:https://www.instagram.com/pendulumlifeco/https://twitter.com/Pendulum_Cohttps://www.facebook.com/PendulumLife/https://www.linkedin.com/company/pendulumco/https://www.pendulumlife.comUse Code: MOLLIE10 – for 10% off the first bottle of a subscription order.  SHOW NOTES:

Colleen Cutcliffe, CEO & Co-Founder at Pendulum Therapeutics, shared the story behind her title with us on Saturday, April 10th and Sunday, April 11th, 2021.Colleen has over 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.SUE SAYS"As a young girl growing up in the deep south to immigrant parents, Colleen's experience was not one of racism or discrimination. She recalls the lesson she learned from her parents was that every person, no matter their background, has the absolute power to chart their own course in life. She's taken these values of integrity, hard work and education and applied them directly to her company Pendulum. "Support this podcast at — https://redcircle.com/women-to-watch-r/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Drug resistant superbugs are they more of a threat than C19? Will they overwhelm the healthcare system, reverse a century's worth of medical progress ? Well talk about the real threat and the real God story, hope with DR. Colleen Cutcliffe founder of Pendulum Therapeutics. Also joined by Dr. Shiroko Sokitch, MD- author of HEALING WHEN IT SEEMS IMPOSSIBLE- 7 KEYS TO DEFY THE ODDS. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/michelle-m-mendoza/message

Colleen Cutcliffe is the cofounder and CEO of Pendulum Therapeutics which develops novel interventions that target the human microbiome to improve the lives of patients suffering from a variety of diseases. The company has raised so far $57 million from top tier investors like Sequoia Capital, Khosla Ventures, and True Ventures.

In this episode, we dive into a fascinating and essential topic—gut health—with the brilliant Colleen Cutcliffe, Ph.D., co-founder and CEO of Pendulum Therapeutics. Known for pioneering the next frontier of metabolic health through microbiome-targeted products, Colleen is changing the game in wellness, and she's here to share her journey from scientist to entrepreneur.With a Ph.D. in Biochemistry and Microbiology from Johns Hopkins and experience leading bioscience teams, Colleen's story is both inspiring and relatable. Her role as a mom led her to create Pendulum after her daughter was born prematurely and faced long-term risks from early antibiotics, sparking her mission to develop safe solutions for people with disrupted microbiomes.In this episode, we get real about:Why gut health is everything and how it affects your entire bodyWhat you should be doing to keep your gut in checkThe latest in gut health science and how it can empower you to live your healthiest lifeThe impact of early antibiotic use on the microbiome and chronic health issuesThis show is sponsored by Better Help. Get 10% off of your first month with the link betterhelp.com/sosheslaysPromo code SLAYS for 20% off membership first orders.For all things So She Slays visit our site!