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2 episodes with Peyer
2 episodes with Peyer
2 episodes with Peyer
2 episodes with Peyer
2 episodes with Peyer
2 episodes with Peyer
2 episodes with Peyer
2 episodes with Peyer
8 episodes with Peyer
✪WordPress ✪ #JSAprilThe inaugural episode of our DC SECRET FILES podcast — the show that dares to tackle DC Comics' greatest creations in encyclopedic form! Each episode, Frank will be joined by a special guest, in this case, comics writer David Gallaher, to cover characters and concepts from across DC's history. Our discussion of the given property will be married to a piece of original art commissioned by DC to spotlight the same. This time around, we chat about 2001's Golden Age Secret Files and Origins #1, by John Ostrander & Cliff Chiang, as well as a host of other talents on the main and supplemental stories. Plus we read YOUR feedback on the show's promotion!D.E.O. Report [0:00:56]Adventure Heroes of the Pulps [0:05:25]“The Dawn of the Golden Age” by Ostrander & Chiang [0:13:43]Crimson Avenger Profile Page art by Michael Lark [0:22:42]The Golden Age Sandman by Matt Wagner & Gavin Wilson [0:33:33]Fantom of the Fair Profile Page art by Darrin Wiltshire & Chris Malgrain [0:43:34]Blue Beetle (Golden Age) Profile Page art by Darrin Wiltshire & Chris Malgrain [0:49:08]“Scenes from the Class Struggle at J.S.A. Mansion” by Peyer & Grau [0:58:40]Flash I (Jay Garrick) Profile Page art by John Byrne [1:01:14]“The Sentinel” by Peter Gross [1:09:27]Hawkman Profile Page art by Rags Morales [1:10:59]Johnny Thunder Profile Page art by Mark Props [1:19:30]Quicksilver (Max Mercury) Profile Page art by Chris Malgrain [1:27:01]“Show and Tell” by Hernandez-Rosenblatt & Igle [1:33:17]Justice Society of America Profile Page art by Mike Collins & Bob McLeod [1:34:56]Injustice Society of the World Profile Page art by Mike Collins & Bob McLeod [1:47:59]Confidential Communiqués [1:53:35]Have a question or comment? Looking for more great content? Leave comments on our website: Rolled Spine Podcasts Images from this episode on TumblrE-MAIL: rolledspinepodcasts@gmail.comTweet us @rolledspine or skeet host Diabolu Frank on BlueSkyDC Secret Files theme song by Luke Daab
In this episode, we go through the gut-immune axis and mycobiome, focusing on the mechanisms underlying intestinal fungal overgrowth. We highlight the roles of the intestinal mucus layer, intestinal epithelial cells, lamina propria, and secretory immunoglobulin A (sIgA) in maintaining homeostasis and defending against fungal overgrowth. We also detail the pathogenic transition of Candida from its commensal yeast form to an invasive hyphal state, as well as the resulting disruptions to immune function. Topics 1. Introduction to the Gut-Immune Axis and Mycobiome - The gut-immune axis and mycobiome. - Exploring intestinal fungal overgrowth. 2. Overview of the Gastrointestinal Lining - Anatomy of the intestinal lining: lumen and microbiome, mucus layer, epithelial monolayer, and lamina propria. - The dual role of the mucus layer: physical and biochemical barrier. - Composition of mucus. 3. Goblet Cells and Mucus Production - Goblet cells as critical producers of mucin glycoproteins and their role in mucus barrier integrity. - Signals for mucin release, such as mechanical stress. 4. The Lamina Propria and Gut-Associated Lymphoid Tissue (GALT) - Layers beneath the epithelium - Peyer's patches, mesenteric lymph nodes, isolated lymphoid follicles, and intraepithelial lymphocytes. - Immune tolerance and defense against pathogens. 5. Peyer's Patches - Positioning of Peyer's patches. - The transition of microbial density from the small intestine to the colon and its immune implications. 6. Immune Cells in the Lamina Propria - Overview of macrophages, dendritic cells, mast cells, plasma cells, and lymphocytes. - Their role in maintaining immunological equilibrium in the gut. 7. The Mycobiome and Pathogenic Transition of Candida - Candida's transition from yeast to hyphal form. - Regulation of Candida by microbial competition and immune surveillance. - Factors promoting pathogenicity: immune suppression, lacking beneficial microbes, more. 8. Virulence Factors of Candida - Secretion of hydrolytic enzymes such as SAPs and phospholipases. - Degradation of sIgA and its consequences for immune evasion. - Adhesins that facilitate fungal binding. 9. Intestinal Barrier Disruption by Candida - Penetration of the mucus layer and epithelial barrier by Candida hyphae. - Disruption of tight junctions and the resulting increased intestinal permeability. - Inflammatory cascade triggered by fungal antigens and microbial toxins entering the lamina propria. 10. Biofilm Formation - The role of biofilms in shielding fungal cells from immune attack and antifungal treatments. 11. Small Intestinal Fungal Overgrowth (SIFO) - Intestinal dysmotility, low stomach acid, immunocompromise. - Possible symptoms of SIFO. - Discussion of the overlap between SIFO, SIBO, histamine intolerance, and other gastrointestinal conditions. - Root cause. Thank you to our episode sponsors: 1. Shop Fresh Press Farms' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order. 3. Check out Spectrum Sciences' Serums and The Vitamin B12 Protocol here, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Visit synthesisofwellness.com
In this episode, we detail the gut's intricate immune defenses, emphasizing the role of mast cells in inflammation and immune signaling. We extend this conversation to Mast Cell Activation Syndrome briefly going through potential triggers, tests, and symptoms. Finally, we examine the bidirectional relationship between MCAS and Small Intestinal Bacterial Overgrowth (SIBO), illustrating how mast cell mediators and microbial byproducts can drive a cycle of chronic inflammation and increased intestinal permeability. Topics: 1. Introduction to the Gut-Immune Axis - Focus: mast cells, small intestinal bacterial overgrowth (SIBO), and mast cell activation syndrome (MCAS). 2. Anatomy of the Gastrointestinal Lining - Intestinal lumen, microbiome, mucus layer, epithelial monolayer, tight junctions, and lamina propria. - Role of the smooth muscle and deeper layers supporting the mucosal structures. 3. Gut-Associated Lymphoid Tissue (GALT) - Peyer's patches, mesenteric lymph nodes (MLNs), isolated lymphoid follicles (ILFs), intraepithelial lymphocytes (IELs), and dispersed immune cells in the lamina propria. - Function of GALT. 4. Peyer's Patches and Antigen Exposure - Location and function of Peyer's patches. - Role in antigen sampling and processing. 5. Immune Cells in the Lamina Propria - Overview of interspersed immune cell populations. 6. Focus on Mast Cells - Key roles of mast cells in the gut's innate immune system. - Locations with a focus on the lamina propria. 7. Mast Cell Mediators - Histamine - Tryptase: tissue remodeling, impact on intestinal permeability. - Cytokines, prostaglandins, and leukotrienes. 8. Mast Cell Activation Syndrome (MCAS) - Overactivation of mast cells and excessive release of inflammatory mediators. - Effects on gut barrier function. - Pathological behavior due to altered activation thresholds, receptor expression, and tissue environment changes (not resulting from an increased number of mast cells). 9. MCAS Symptoms and Systemic Effects - Abdominal pain, cramping, bloating, diarrhea, and nausea. - Systemic symptoms: skin reactions, respiratory and cardiovascular effects, neurological impacts. 10. Triggers and Conditions Associated with MCAS - Environmental toxins, infections, stress, chemical exposures. - Hypermobile Ehlers-Danlos syndrome (hEDS), dysautonomia (e.g., POTS). 11. MCAS Testing - Testing limitations: variability in mediator release and transient nature of mast cell degranulation. - Serum tryptase, urinary N-methylhistamine, plasma heparin levels, specific cytokines like IL-6, and more. 12. Small Intestinal Bacterial Overgrowth (SIBO) - Overview of SIBO. - Slow motility, low stomach acid. 13. Interaction Between SIBO and Mast Cells - SIBO-induced mast cell activation. - Cycle of inflammation, increased intestinal permeability, and gut dysfunction. 14. Conclusion - Recap of the intestinal anatomy and immune cell focus. - MCAS triggers, symptoms, and testing. - Connections between SIBO and MCAS, emphasizing an inflammatory cycle. Thank you to our episode sponsor: 1. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
In this special bonus episode, we delve into the innovative intersection of sports and e-commerce with Patrick Jenkinson, Commercial Director for Venue and E-commerce at Manchester United, and Thomas Peyer, Director, Growth, SCAYLE, a leading enterprise e-commerce platform.Patrick shares insights into Manchester United's remarkable global fan base, boasting over 270 million social followers and viewership that rivals global sporting events like the Super Bowl. Highlighting the club's transition from an outsourced to an in-house e-commerce model, Patrick emphasizes the importance of providing a seamless, unified shopping experience that caters to fans worldwide, regardless of location or language.Thomas discusses SCAYLE's unique approach to enterprise e-commerce, rooted in modern architecture and API-driven platforms. He explains how Scale enables organizations like Manchester United to integrate diverse digital offerings, from merchandise to content subscriptions, fostering deeper fan engagement and loyalty.The conversation also explores broader retail trends, emphasizing the significance of loyalty programs, unified commerce, and agile technology to meet evolving consumer expectations. With a record-breaking Black Friday and ambitious plans for international growth, Manchester United and SCAYLE exemplify the potential of combining heritage with cutting-edge technology to deliver unparalleled customer experiences.Tune in for a compelling discussion that showcases how innovative partnerships are reshaping the business of sports and retail.This episode is brought to you by SCAYLE, the world's fastest growing enterprise commerce platform. Patrick JenkinsonManchester UnitedCommercial Director Venue & E-CommercePatrick Jenkinson is responsible for revenue across direct-to-fan products at Manchester United. He oversees a broad range of business units across the physical and digital realms including retail, content, and subscriptions, serving one of the biggest fan audiences in sport. Patrick joined the club from Leeds United where he served as Head of Business Development and prior to this he was a VP at DAZN, the world's largest live sport streaming service. At DAZN, he held in-market leadership roles in Japan and Spain as well as overall responsibility for international expansion. He began his career in TMT M&A followed by sports & media private equity. Thomas Peyer, SCAYLEDirector of GrowthThomas is Director Growth and part of the Management Team at SCAYLE. He is tasked with growing SCAYLE's business beyond its home market Germany. Before joining SCAYLE, Thomas worked at adidas as VP Advanced Analytics, where he was responsible for all AI / ML products for the brand. Thomas spent his formative years as a McKinsey consultant and in Private Equity. He holds a MSc in Economics from the London School of Economics and an MBA from INSEAD. About UsSteve Dennis is a strategic advisor and keynote speaker focused on growth and innovation, who has also been named one of the world's top retail influencers. He is the bestselling authro of two books: Leaders Leap: Transforming Your Company at the Speed of Disruption and Remarkable Retail: How To Win & Keep Customers in the Age of Disruption. Steve regularly shares his insights in his role as a Forbes senior retail contributor and on social media.Michael LeBlanc is the president and founder of M.E. LeBlanc & Company Inc, a senior retail advisor, keynote speaker and now, media entrepreneur. He has been on the front lines of retail industry change for his entire career. Michael has delivered keynotes, hosted fire-side discussions and participated worldwide in thought leadership panels, most recently on the main stage in Toronto at Retail Council of Canada's Retail Marketing conference with leaders from Walmart & Google. He brings 25+ years of brand/retail/marketing & eCommerce leadership experience with Levi's, Black & Decker, Hudson's Bay, CanWest Media, Pandora Jewellery, The Shopping Channel and Retail Council of Canada to his advisory, speaking and media practice.Michael produces and hosts a network of leading retail trade podcasts, including the award-winning No.1 independent retail industry podcast in America, Remarkable Retail with his partner, Dallas-based best-selling author Steve Dennis; Canada's top retail industry podcast The Voice of Retail and Canada's top food industry and one of the top Canadian-produced management independent podcasts in the country, The Food Professor with Dr. Sylvain Charlebois from Dalhousie University in Halifax.Rethink Retail has recognized Michael as one of the top global retail experts for the fourth year in a row, Thinkers 360 has named him on of the Top 50 global thought leaders in retail, RTIH has named him a top 100 global though leader in retail technology and Coresight Research has named Michael a Retail AI Influencer. If you are a BBQ fan, you can tune into Michael's cooking show, Last Request BBQ, on YouTube, Instagram, X and yes, TikTok.Michael is available for keynote presentations helping retailers, brands and retail industry insiders explaining the current state and future of the retail industry in North America and around the world.
Wort zum Tag - Laienpredigerin Yvonne Peyer, Basel BSFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an: info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
Wort zum Tag - Laienpredigerin Yvonne Peyer, Basel BSFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an: info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
Wort zum Tag - Laienpredigerin Yvonne Peyer, Basel BSFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an: info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
Wort zum Tag - Laienpredigerin Yvonne Peyer, Basel BSFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an: info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
Wort zum Tag von Laienpredigerin Yvonne Peyer, BaselFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
Wort zum Tag von Laienpredigerin Yvonne Peyer, BaselFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
durée : 00:58:17 - Gervase de Peyer, chaleur et souplesse de la sonorité - par : Aurélie Moreau - Né à Londres en 1926, Gervase de Peyer a joué au sein d'orchestres et notamment comme clarinette solo du Symphonique de Londres. Sa sonorité chaleureuse a fait de lui un soliste et un chambriste d'exception qui a inspiré de nombreuses compositions.
Wort zum Tag - Laienpredigerin Yvonne Peyer, Basel BSFeedback ist immer willkommen! Ob dieser Beitrag gefallen hat oder nicht, alle Autorinnen und Autoren schätzen jede Rückmeldung. Die direkte Mailadressen des Autors / der Autorin finden sie direkt im Player unter Email. Oder Sie schicken ihn direkt an info@wortzumtag.chWir freuen uns über Ihr Feedback!Wenn Sie das "Wort zum Tag" unterstützen möchten, können Sie dies einfach über Twint tun. Ihre Unterstützung ermöglicht es uns, weiterhin täglich inspirierende Beiträge zu publizieren. Vielen Dank für Ihre Großzügigkeit!Den Twint QR Code finden Sie auf der Webseite «Wort zum Tag»https://wortzumtag.ch/idee/unterstuetzung
In today's episode, we go through the intricacies of lymphatic health in order to understand the mechanisms behind lymphatic congestion, fluid accumulation, and poor immune function. We highlight the pivotal role of white blood cells in orchestrating immune responses and emphasize diverse strategies for maintaining lymphatic flow. We go over herbal supplements, physical therapies, and peptide interventions, also evaluating whether or not they are research-backed. Topics: 1. Introduction to Lymphatic System and its Importance - Definition and Composition of Lymph - Functions of Lymphocytes (T cells, B cells, T cell types, and antibodies) 2. Components of the Lymphatic System - Lymphatic vessels - Lymph nodes - Bone marrow and thymus - Other lymphoid organs (Spleen, Tonsils, Adenoids, Peyer's patches) 3. Role of White Blood Cells (WBCs) in the Lymphatic System - Macrophages in innate immunity - Dendritic cells in antigen presentation - Adaptive immune response initiation 4. Causes and Effects of Lymphatic Congestion - Pathogen invasion and immune response - Inflammation and swelling of lymph nodes - Impaired lymphatic fluid flow and drainage 5. Strategies for Supporting Lymphatic Health - Herbal and Nutritional Support - Ginger, Ginseng, Cleavers, Red Clover, Echinacea, Burdock Root, Calendula - Physical Therapies - Exercise, Rebounding, Vibration Therapy, Manual Lymphatic Drainage - Peptide Therapies (Personal Thoughts & Use) - Thymosin alpha 1, Ovagen, Crystagen 6. Conclusion - Importance of holistic approach to lymphatic health - Always work with a licensed medical professional Thank you to our episode sponsor: Check out MoonBrew Here! Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
ORDER ALEX'S BOOK HERE https://www.whsmith.co.uk/products/ou... ABOUT ALEX Stand-up-comedian turned priest's tale of generosity and compassion to HarperNorth HarperCollins today announce the acquisition of Our Daily Bread: From Argos to the Altar – a Priest's Story by Father Alex Frost. Jonathan de Peyer, senior commissioning editor, acquired World All Languages rights from Jane Graham-Maw of Graham Maw Christie for HarperNorth. The book will publish in hardback, ebook and audio in October 2022, with a foreword from fellow son of Burnley Alastair Campbell. Our Daily Bread is a warmly funny, intensely moving and personal account of the lives of an urban parish priest and his parishioners. De Peyer said: ‘Father Alex has written a wonderful book that reminds us of the bonds that can be forged between people in adversity. Unpretentious, faithful to the stories of those whose lives Alex has touched, funny, and above all timely, Our Daily Bread is a salve in this time of acute crisis.' Father Alex Frost found his calling while running an Argos store in his native Burnley, moonlighting as a stand-up comedian. Once he became a priest, he quickly realised his 17,000 parishioners were in dire need of help. And so it was that during Covid he found himself running a food bank from a car park, helping the desperate amid his flock as the pandemic raged. Fr Alex's down-to-earth style of ministry has struck a chord with people of all faiths, cultures and class, and amid the tragedy, addiction, illness and neglect, there also lies hope, joy and comedy. Our Daily Bread is about the lives of the characters that cross the threshold of any church. Through them it shows the continued service of the church for the poor and the marginalised. Frost said: ‘It's such an honour to give a voice to some incredible people living through these tough times. It's my wish that the book is read by anyone concerned with the effects of the pandemic and the cost of living crisis upon Britain's poorest, and I truly hope it helps change things for the better. HarperNorth feels like a natural home with its mission to bring books from the North to the world.'The God Cast with Fr Alex Frost
Wort zum Tag - Laienpredigerin Yvonne Peyer, Basel BS
An arrest, two trials, and a heartbroken father. After Cara Knott was murdered in December of 1986 police honed in on a suspect, one of their own, California Highway Patrolman, Craig Peyer. Nineteen days after the murder Peyer was arrested but it would take two trials before a jury finally rendered a verdict. For some it was hard to believe a “good cop” could commit such a heinous crime. In the aftermath of Cara's murder, her father, Sam Knott fought for major changes in the criminal justice system. Least of These on Facebook: https://m.facebook.com/leastofthesepodcast/ Least of These Discussion Group: https://m.facebook.com/groups/288046119723080/?ref=pages_profile_groups_tab&paipv=1 Least of These on Instagram: www.instagram.com/least_ofthese/ Support the show and get your episodes ad free at: https://www.patreon.com/leastofthesepodcast Learn more about your ad choices. Visit megaphone.fm/adchoices
Cara Knott, a 20 year old San Diego State University student, was pulled over by California Highway Patrol Officer Craig Peyer. Cara was murdered by Peyer off of the Mercy Rd exit in San Diego County.. She was then thrown off of the Los Penasquitos Arch Bridge where she was discovered the next morning by family and police. Watch Full Episode: https://youtu.be/FC4huQrqaQk
James Peyer is the CEO and Founder of Cambrian. Peyer's goal with his pharma-bio company is to create healthier drugs that lengthen lifespans and improve overall health in individuals. Peyer was previously Managing Partner with Apollo Ventures, the first global longevity-focused venture capital firm. He is a graduate of UT Southwestern (National Science Foundation Fellow) with a PhD in blood and stem cell biology.James and Diane Brady speak at Founder's Forum about Cambrian's newest business developments, timelines of producing Cambrian's products and how a healthier lifestyle holds as much influence as good medicine.Stay ConnectedForbes newsletters: https://newsletters.editorial.forbes.comForbes on Facebook: http://fb.com/forbesForbes Video on Twitter: http://www.twitter.com/forbesForbes Video on Instagram: http://instagram.com/forbesMore From Forbes: http://forbes.comForbes covers the intersection of entrepreneurship, wealth, technology, business and lifestyle with a focus on people and success.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
How can we live longer and healthier? James Payer has dedicated his career to finding out. Hear his story. James Peyer is the Chief Executive Officer and Founder of Cambrian Bio. He also holds multiple board and executive roles across Cambrian's pipeline. He has spent his entire life dedicated to the mission of finding ways of preventing people from getting diseases like cancer and Alzheimer's instead of waiting for people to get sick. James was previously Founder and Managing Partner at Apollo Ventures, the first global longevity-focused venture capital firm, investing across the US and Europe. Prior to Apollo, James was a biotech R&D specialist at the New York office of McKinsey & Company, serving major pharmaceutical clients. He earned his PhD in stem cell biology at University of Texas Southwestern Medical Center as a National Science Foundation Fellow and received his B.A. with special honors from the University of Chicago.
I brought two top Silicon Valley entrepreneurs working on extending lifespans on the Newcomer podcast this week. One of them is trying to help people live longer. The other, their dogs.James Peyer, the CEO of Cambrian Bio, is acquiring majority stakes in drugs that could combat a particular illness while showing promise for broader use among healthy humans. Meanwhile, Celine Halioua, the CEO of Loyal, is developing drugs to make dogs live longer. Fundamentally life extension, or longevity, is about finding drugs and treatments that can be given to healthy humans to help them live longer, healthier lives. Instead of just treating illnesses, entrepreneurs in the space want to find ways to stave off aging in already healthy people. The space has long been a fascination of mine. In February 2022, I profiled Elad Gil's investments in an array of companies looking to make healthy humans live longer, healthier lives.The HBO show Silicon Valley helped popularize the idea that Silicon Valley elites were pumping their veins with younger people's blood. (I've yet to get anyone to confess to me that they're buying plasma.)To the chagrin of this week's guests, one tech mogul desperate to avoid death has received a lot of the attention recently. That's Braintree founder Bryan Johnson. Time magazine just profiled Johnson under the headline “The Man Who Thinks He Can Live Forever.” Johnson, 46, is a centimillionaire tech entrepreneur who has spent most of the last three years in pursuit of a singular goal: don't die. During that time, he's spent more than $4 million developing a life-extension system called Blueprint, in which he outsources every decision involving his body to a team of doctors, who use data to develop a strict health regimen to reduce what Johnson calls his “biological age.” That system includes downing 111 pills every day, wearing a baseball cap that shoots red light into his scalp, collecting his own stool samples, and sleeping with a tiny jet pack attached to his penis to monitor his nighttime erections. Johnson thinks of any act that accelerates aging—like eating a cookie, or getting less than eight hours of sleep—as an “act of violence.” Even as Johnson is getting a lot of attention for his self-experimentation, there's a growing view that there could be something credible behind Silicon Valley's interest in life extension. The Economist just wrote that “slowing human ageing is now the subject of serious research.”Many in mainstream science and medicine look at all this slightly askance. That is understandable. It is an area which attracts chancers and charlatans as well as those with more decent motives, and its history is littered with “breakthroughs” that have led more or less nowhere. America's Food and Drug Administration does not recognise “old age” as a disease state, and thus as a suitable target for therapy. Nevertheless, evidence has been accumulating that such research might have something to offer.Some established drugs really do seem to extend life, at least in mice. That offers both the possibility that they might do so in people and some insight into the processes involved. The ever-greater ease with which genes can be edited helps such investigations, as does access to large amounts of gene-sequence data. The ability to produce personalised stem cells, which stay forever young, has opened up new therapeutic options. And new diagnostic tools are now offering scientists means to calculate the “biological ages” of bodies and organs and compare them with actual calendar ages. In principle this allows longevity studies to achieve convincing results in less than a lifetime.I dug in with Halioua and Peyer about where they saw the most opportunities, how their own companies were progressing, and why they thought Johnson's publicity campaign was doing a disservice to companies working on longevity. The duo helped break down the space, discussing which types of companies they think are innovators, which efforts are more speculative moonshots, and which ones are simply snake oil. Give it a listen. Get full access to Newcomer at www.newcomer.co/subscribe
I brought two top Silicon Valley entrepreneurs working on extending lifespans on the Newcomer podcast this week. One of them is trying to help people live longer. The other, their dogs.James Peyer, the CEO of Cambrian Bio, is acquiring majority stakes in drugs that could combat a particular illness while showing promise for broader use among healthy humans. Meanwhile, Celine Halioua, the CEO of Loyal, is developing drugs to make dogs live longer. Fundamentally life extension, or longevity, is about finding drugs and treatments that can be given to healthy humans to help them live longer, healthier lives. Instead of just treating illnesses, entrepreneurs in the space want to find ways to stave off aging in already healthy people. The space has long been a fascination of mine. In February 2022, I profiled Elad Gil's investments in an array of companies looking to make healthy humans live longer, healthier lives.The HBO show Silicon Valley helped popularize the idea that Silicon Valley elites were pumping their veins with younger people's blood. (I've yet to get anyone to confess to me that they're buying plasma.)To the chagrin of this week's guests, one tech mogul desperate to avoid death has received a lot of the attention recently. That's Braintree founder Bryan Johnson. Time magazine just profiled Johnson under the headline “The Man Who Thinks He Can Live Forever.” Johnson, 46, is a centimillionaire tech entrepreneur who has spent most of the last three years in pursuit of a singular goal: don't die. During that time, he's spent more than $4 million developing a life-extension system called Blueprint, in which he outsources every decision involving his body to a team of doctors, who use data to develop a strict health regimen to reduce what Johnson calls his “biological age.” That system includes downing 111 pills every day, wearing a baseball cap that shoots red light into his scalp, collecting his own stool samples, and sleeping with a tiny jet pack attached to his penis to monitor his nighttime erections. Johnson thinks of any act that accelerates aging—like eating a cookie, or getting less than eight hours of sleep—as an “act of violence.” Even as Johnson is getting a lot of attention for his self-experimentation, there's a growing view that there could be something credible behind Silicon Valley's interest in life extension. The Economist just wrote that “slowing human ageing is now the subject of serious research.”Many in mainstream science and medicine look at all this slightly askance. That is understandable. It is an area which attracts chancers and charlatans as well as those with more decent motives, and its history is littered with “breakthroughs” that have led more or less nowhere. America's Food and Drug Administration does not recognise “old age” as a disease state, and thus as a suitable target for therapy. Nevertheless, evidence has been accumulating that such research might have something to offer.Some established drugs really do seem to extend life, at least in mice. That offers both the possibility that they might do so in people and some insight into the processes involved. The ever-greater ease with which genes can be edited helps such investigations, as does access to large amounts of gene-sequence data. The ability to produce personalised stem cells, which stay forever young, has opened up new therapeutic options. And new diagnostic tools are now offering scientists means to calculate the “biological ages” of bodies and organs and compare them with actual calendar ages. In principle this allows longevity studies to achieve convincing results in less than a lifetime.I dug in with Halioua and Peyer about where they saw the most opportunities, how their own companies were progressing, and why they thought Johnson's publicity campaign was doing a disservice to companies working on longevity. The duo helped break down the space, discussing which types of companies they think are innovators, which efforts are more speculative moonshots, and which ones are simply snake oil. Give it a listen. Get full access to Newcomer at www.newcomer.co/subscribe
I had the pleasure of spending a day at Cat World in Best Friends Animal Sanctuary in Kanab, UT. I had lunch and a chance to interview a beautiful soul, Jana de Peyer, Co-founder of the Sanctuary. I took plenty of my favorite Vitakraft Lick 'n Lap cat treats to share, and got to meet some of the amazing staff and feline residents.
I had the pleasure of spending a day at Cat World in Best Friends Animal Sanctuary in Kanab, UT. I had lunch and a chance to interview a beautiful soul, Jana de Peyer, Co-founder of the Sanctuary. I took plenty of my favorite Vitakraft Lick 'n Lap cat treats to share, and got to meet some of the amazing staff and feline residents.
Synopsis: James Peyer, Ph.D., is the Founder and CEO of Cambrian Bio, a clinical-stage drug-development company focused on creating therapies to prevent and cure age-related diseases. James discusses the driving force behind his interest in aging biology and oncology, how his perspective on aging has changed over the years, his entrepreneurial journey, and what he hopes to achieve over the next decade with PipeCos such as Telos, Amplifier, and Tornado. He also discusses the inherent risk involved in drug development, how he manages the emotional aspects, and Cambrian's vision for the future of drug development. Biography: James Peyer is the Chief Executive Officer and Founder of Cambrian Bio. He also holds multiple board and executive roles across Cambrian's pipeline. He has spent his entire life dedicated to the mission of finding ways of preventing people from getting diseases like cancer and Alzheimer's instead of waiting for people to get sick. James was previously Founder and Managing Partner at Apollo Ventures, the first global longevity-focused venture capital firm, investing across the US and Europe. Prior to Apollo, James was a biotech R&D specialist at the New York office of McKinsey & Company, serving major pharmaceutical clients. He earned his PhD in stem cell biology at University of Texas Southwestern Medical Center as a National Science Foundation Fellow and received his B.A. with special honors from the University of Chicago. Interested to learn more: Telos: https://www.telosbio.com/ Amplifier: https://www.amplifier-tx.com/ Tornado: https://www.tornado-tx.com/
In pursuit of mechanisms and evidence-based approaches, gut health has been revealed as a critical cornerstone of neurological health. In this episode, we're going into detail on what the gut layers are. I hope this video will help someone else who's trying to understand how the gut works for purposes of biohacking with functional medicine, nutrition, supplements, etc. For any intervention, is there evidence of a relationship, and is there data that it worked in other humans? We talk about: what the gut mucus is made out of elements of the gut barrier - the many ways the body keeps microbes and partially digested food away kinds of intestinal epithelial cells (Goblet cells, Paneth cells, M cells, etc.) and their functions types of gut associated lymphoid tissue (GALT) and their distinctions - lamina propria, Peyer's patches, lymph nodes the enteric nervous system and enteroendocrine cells different types of CD4+ T cells: Th1, Th2, Th17, and Treg, what they respond to, and their major outputs the mechanism of nutrient absorption the mechanism of leaky gut (paracellular transport through tight junctions) Here's the video: https://youtu.be/sIn_VxH6zDA Transcript of the video, for those who are pressed for time: https://www.brainforest.org/post/leaky-gut-anatomy I hope this helps someone understand their gut a little better on the path to health. Stay tuned for our next podcast on the relationship between leaky gut and aging. Share this resource with others who are studying gut anatomy on the path to health!
Julia Peyer, 51, Anästhesistin, Unternehmerin, Hanbekks-Freundin. Im Gespräch erzählt Julia, wie es ist, von der REGA im Gebirge als Rettungsärztin abgeseilt zu werden, ob man sich Propofol selbst verabreichen kann und warum es Frauen eher schlecht wird nach einer Vollnarkose als Männern.
As James Peyer, the CEO of Cambrian Biopharma Inc., watched his grandfather fail every cancer treatment and pass away, he also saw the structure of his future company being born. Waiting until people became sick was the wrong way to treat disease, he found. Instead, Cambrian was created to develop anti-aging therapies, a unique business model that fits the new field of geroscience. To do that, Cambrian became a biotech business, a VC fund and an incubator. Peyer spoke to the BioWorld Insider Podcast about his pipeline and how he goes about fundraising in a little understood field. Hosted on Acast. See acast.com/privacy for more information.
Holy unexpected projects, Batman! Chris (on a solo mission this week) gives you a quick run down and reactions announcement of the (new) first chapter of the DC Universe media projects. James Gunn laid out the road map to upcoming movies and TV projects, and we're here for it! Chris also talks about known inspirations for some of the projects discussed listed below: All-Star Superman by Morrison, Quietly, and Grant The Authority by Ellis, Millar, Peyer, Hitch, Nguyen, and Quietly Batman by Morrison, Hubert and Delperdang Absolute Swamp Thing by Moore, Bissette, Totleben, and Veitch Supergirl: Woman of Tomorrow by King, Evely, and Lopes Comic Book Keepers is hosted by the Geekly Grind. Check out reviews and discussion on everything Geeky from Anime, Manga, Boardgames, comics, and more. www.thegeeklygrind.com The Geekly Grind @thegeeklygrind Link tree: https://linktr.ee/CBKcast Social media: Twitter @cbkcast Instagram @cbkcast Facebook Chris @dungeonheads Lance @roguesymbiote Chris's draws free D&D art which you can find and support him on Patreon, and see more of his art on Instagram Original Theme by Weston Gardner @ArcaneAnthems on Patreon
Regierungsrat Peter Peyer hat heute den überraschenden Abgang des Leiters des Amt für Migration und Zivilrecht begründet. Marcel Suter habe zwar keine Fehler gemacht, für die Neuausrichtung des Amtes sei er aber der Falsche. Peyer möchte das Amt zu einem Dienstleistungszentrum entwickeln. Weitere Themen: * Kommission für Justiz und Sicherheit nimmt Stellung zu Strafuntersuchung gegen Bündner Verwaltungsrichter. * Celerina sagt Ja zum Wohnraumförderungsgesetz. * La Punt Chamues-ch ist das grösste Bündner Steuerparadies. * HC Davos präsentiert Pläne für Frauenteam.
This founder has been part of so many of the exciting longevity startups, investments, and discussions that you simply must understand the world the way he sees it before taking a view about life extension. In this episode, you will.
On the fourth and final installment of CoinGeek Conversations Special, we'll hear from individuals whose companies' ESG or environmental, social, and corporate governance initiatives are achieved through blockchain technology. While it seems like blockchain is not usually associated with ESG, these companies are making strides in proving how the technology can play a vital role in the industry. Joe Holles de Peyer of Gate2Chain and Daniel Keane of Predict Ecology talk about the integrity that blockchain provides while recording data on the environment; Dave Perill of Compute North talks about how blockchain provides efficiency in data centers; and Bryan Daugherty discussed his project, Proof of ESG and explained why blockchain will make the world a greener place.
“Shaping a healthy gut microbiome from birth is really the best way to support healthy and happy kids for their lifetime,” says Dr. Elisa Song, an integrative pediatrician and pediatric medical expert. Seventy percent of our immunity starts in our gut, and the diseases that start with an unhealthy gut go far beyond stomach issues. Autoimmune disorders, allergies, skin problems, and psychological issues are a result of an unhealthy gut microbiome. In fact, the brain and the gut are so connected that some cultures consider the gut “the first brain,” as the brain actually listens to it and can't survive without it. The gut, with its own separate nervous system, can survive without the brain. When their communication breaks down, that's when the problems start. Setting up a healthy gut biome early in a child's life is crucial, and there are ways to remedy an unhealthy one, including a regiment used by holistically minded pediatricians called “The Five Rs.” These include Replacing and Re-inoculating. Probiotics are crucial, (and conversely, antibiotics are a huge culprit) and should be found in the diet whenever possible. Reducing food preservatives, which are a huge contributing factor to an unhealthy gut, is also crucial. Join the conversation to hear Dr. Elisa discuss the other three Rs, the difference between leaky gut, gut dysbiosis, and gut imbalance, and what to expect from her forthcoming book. Quotes • “A lot of times, the gut is at the root of so many things.” (8:48-8:53 | Sasha) • “We have to think, ‘Who are we? Who are we nourishing? Who are we supporting? Who are we trying to help thrive?” (10:11-10:18 | Dr. Elisa) • “Shaping a healthy gut microbiome from birth is really the best way to support healthy and happy kids for their lifetime.” (10:45-10:56 | Dr. Elisa) • “The gut/brain connection is interesting because some would actually call the brain ‘the second brain, and the gut the first brain.'”(12:48-12:55 | Dr. Elisa) • “For the most part, babies' guts are an open slate, ready to be shaped.” (21:53-21:59 | Dr. Elisa) • “Talk to kids, from the moment they're little to the time they become teenagers, why the gut matters and make it matter for them. What matters to kids, teenagers? It's their skin!...How do we get our gut clean?” (37:09-37:43 | Dr. Elisa) • “Those food additives are one of the biggest factors in disrupting our gut microbiome in the modern world.” (1:04:10-1:04:15 | Dr. Elisa) • “Most times if you have to look it up, it usually isn't good for you.” (1:09:16-1:09:20 | Sasha) • “All health starts in the gut. Hippcrates, the father of modern medicine, is credited with saying that.”(1:09:30-1:09:36 | Dr. Elisa) Stats • “The gut is home to 70% of the immune system.” (0:13-0:18 | Sasha) • “It is believed that before the age of four or five, a child's microbiome remains flexible. (0:18-0:25 | Sasha) • “Inflammation can manifest itself in many different ways, through environmental allergies, food sensitivities, autoimmune diseases, constipation, eczema and more.” (0:45-0:56 | Sasha) • “The gut microbiome is that collection of over 100 zillion organisms in our gut.” (9:32-9:40 | Dr. Elisa) • “It's an amalgam of bacteria, viruses, yeast, parasites, all living together (hopefully) in harmony with our human cells. We have more microbial cells in and on our body than we have human cells.” (9:51-10:10 | Dr. Elisa) • “Our gut microbiome is responsible for the vast majority– 90 to 95 percent–of all of our brain chemicals, our neurotransmitters, like serotonin (11:15-11:31 | Dr. Elisa) • “The balance of our gut microbiome has been linked to virtually every single chronic disease in children and adults. (11:38-11:47 | Dr. Elisa) • “The gut has its own nervous system called the enteric nervous system which can actually live without the brain, but the brain can't live without the gut's nervous system.” (12:56-13:13 | Dr. Elisa) • “The gut and the brain communicate via a two-way information superhighway called the vagus nerve.” (13:15-13:24 | Dr. Elisa) • “80-90 percent of the communication in the vagus nerve happens from the gut to the brain. That means that only about 10-20 percent happens from the brain to the gut.”(14:09-14:24 Dr. Elisa) • “A study no toddler's gut microbiome found that the different mix of gut bacteria actually help shape our kids' temperaments.” (14:37-14:48 | Dr. Elisa) • “In that hollow tube, from our mouth, esophagus, stomach, large and small intestine, all the way to our anus are lined with tonsil-like patches called Peyer's patches, and that makes up what's known as the gut associative lymphoid tissue.” (16:27-16:48 | Dr. Elisa) • “Babies who are given antibiotics or antacid medications in the first years of life, by the time they were four years of age have a significantly increased risk of every single allergic disease, including asthma, eczema, anaphylactic food allergies, hives, you name it.” (23:05-23:24 | Dr. Elisa) • "Hashimoto's and thyroid problems are an increasing problem among teenagers, and in fact there is an autoimmune marker called an ANA (Antinuclear antigen). It's a red flag.” (33:43-34:05 | Dr. Elisa) • “At a recent conference, there were discussion about the projection that by 2050, antibiotic resistance could be one of the leading causes of death.”(46:02-46:16 | Dr. Elisa) • “Our body can't distinguish between psychological or physical or infectious stress. Psychological stress yields the same amount of inflammation as physical stress.” (56:53-57:03 | Dr. Elisa) • “The food additive industry was created to make food sweeter, saltier, look better, last longer, and be more addictive.” (1:03:36-1:03:48 | Dr. Elisa) Notable links: Connect with Dr. Elisa Song: Website: www.healthykidshappykids.com IG: @healthykids_happykids FB: fb.com/drelisasongmd Subscribe to our Mailing List: www.TheOfficialMomologist.com Connect with The Momologist™: IG: https://www.instagram.com/theofficialmomologist/ FB: https://www.facebook.com/TheOfficialMomologist ------ The Momologist™ is a production of The Reel Media Group. For inquiries, please email: contact@thereelmediagroup.com DISCLAIMER: The views provided in this episode and the show notes are for informational purposes only. No material is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have heard on this episode.
Jim Mellon co-founder of The Longevity Forum leads a discussion with Kristen Fortney, CEO and founder of BioAge Labs and James Peyer, CEO and founder of Cambrian Biopharma on the future of youth's interest in longevity. Ageing is universal – it happens to everyone compared to other diseases. Kristen and James discuss how organisations are working towards preventing this universal inevitability. From recent breakthroughs to the financial climate for biotech funding, these biotech pioneers open our eyes to the amazing progress in the industry. https://bioagelabs.com https://www.cambrianbio.com https://thelongevityforum.com
For Joe Holles de Peyer, co-founder and COO of Gate2Chain, his ‘eureka' moment came, as so many of the best ideas do, from his experience of a real-world issue. When he was living and working in Mallorca, the Port of Palma set up an IoT sensor infrastructure to measure the air quality of the island's capital. Despite a regular influx of pollution-causing cruise ships the data that was presented claimed the air quality was perfect. Joe says that as he knew this wasn't the case and he lost trust in the data. With IoT, he says, “there are so many steps in the process, so many things that can go wrong, from not cleaning a filter to actually manipulating the data when you put it on your computer.” As he tells Charles Miller on this week's CoinGeek Conversations, this was when he and his team started experimenting with implementing blockchain with IoT devices and discovering the power of the technology to prove data integrity. He found that using blockchain, he could program devices to behave in certain ways dependent on real-time information, while also certifying the accuracy of data through a signing mechanism. The ‘eureka' moment, he explains, is the realisation that “the blockchain allows us to send, to share, to store information and value on the same protocol. On the old internet we were just sharing information and now thanks to the blockchain we can also share value and attach value to information and share it on the same protocol.” Joe originally chose the Ethereum blockchain to build on but switched over to the BSV blockchain when he realised the former wasn't fit for purpose. Gate2Chain is now utilising the power of the BSV blockchain through two sets of products. The first is an easy-to-use developer suite which allows users to connect new or existing apps, websites, games, or any other system to the blockchain. The second service, which is currently in development, is called Minta. “It's a one-stop shop, it's a wallet, a bank account, it's integrated also with a conventional bank so you can actually have your euros, your dollars, your dirhams, it's an NFT minter, it's a marketplace, it has a messaging app in it, it's a bit of everything.” Joe explains how a service like this can provide real-world value, giving the example of a freelance photographer. Instead of using a third-party system to send photos and a separate payment platform to receive the money, this could all be handled in the Minta platform. Photos would be uploaded in the form of NFTs and shared with a client with a value already programmed in. The money could then flow directly from one account to another, removing any need for trust for both parties. Minta is being built to be user-friendly as Joe wants to ensure that Gate2Chain's services are accessible for everyone, not just for those with technical knowhow. “It's about making blockchain easy,” he says. The easier the products are for people to use, the more appealing they will be to the everyday user and the wider adoption is likely to be. This will bring Joe one step closer to his goal of revolutionising the internet and creating a digital world better suited for the people using it.
DOWNLOAD FULL SHOW NOTES WITH DIAGRAMSIn this episode I'm going to talk about the immune system, specifically the lymphatic system and the microbiome. I'm also going to talk a little bit about detoxing the body from the spike protein and what we might be able to do for any DNA damage that has occurred from the mRNA vaccines. So to begin with, the lymphatic system is poorly misunderstood and largely ignored still by the medical community. But it's just as important as the blood, if not more important as an indicator for illness. The lymphatic system is a network that's comprised of organs, vessels, nodes and fluid. The primary organs are the bone marrow and the thymus. The secondary organs are the nodes, the tonsils, spleen and Peyer's Patches, which is also called GALT, or gut assisted lymphatic tissue, which will be discussed later in the second part of this podcast when we talk about the microbiome. The reason we want to understand what the lymphatic system does is because it's one of the vital parts of the immune system. The immune system is your most effectual weapon against almost anything that can enter the body and create problems. I hope to be able to explain what makes the lymphatic system thrive and what puts more of a burden on it so that you can make any lifestyle course corrections to ensure more toxins are going out than coming in. The lymphatic system runs alongside the cardiovascular system. It's in all the capillary beds and interstitial spaces and in every organ. It connects in with the blood and helps cleanse and clear the blood. We have three times more lymph fluid than blood. Lymph nodes and vessels go from head to toe. Lymphatic vessels transport fats and cells of the immune system; the lymphatic and immune systems work closely together....DOWNLOAD FULL SHOW NOTES WITH DIAGRAMS
The cover of Batman '66 #9 includes Zelda the Great hanging above the Duo, and Shame's boots in the foreground. Zelda's in the issue, but where's Shame? Um... in issue #8?! (We discussed that story in episode 182!) Jeff Parker's Zelda story has its moments, but in other ways it's just weird. Meanwhile, Tom Peyer's backup story brings back Alfred's cousin Egbert from The Joker's Provokers, but brings to mind what a version of Alfred in Peyer's The Wrong Earth might have been like! This time, we discuss issue 9. Also, we give our own answers to some previously posted bat-questions, hear more of Adam on The Merv Griffin Show, read a bit of mail, and listen to Pylon's version of Hefti's Bat-theme.
Like a lot of successful entrepreneurs, James Peyer is a bit of an outlier. He thinks about something differently: Aging. To James, aging is a curable illness, something to be treated or prevented. He sits down with Jessi for a conversation on what led him to create Cambrian Biopharma, and why unorthodox ideas are so critical to the development of society and culture. Follow Jessi Hempel on LinkedIn Follow James Peyer on LinkedIn Join the Hello Monday community: Subscribe to the Hello Monday newsletter, and join us on the LinkedIn News page each week for Hello Monday Office Hours, Wednesdays at 3p ET.
In den kommenden beiden Wochen nehmen wir die Kandidierenden für die Bündner Regierung in die Zange. Den Auftakt macht der bisherige SP-Regierungsrat Peter Peyer. Weitere Themen: * Überraschungskandidat Hans Vetsch stellt sich vor. * Spendenaktion fürs Frauenhaus Graubünden.
We’re looking at L.E.G.I.O.N. #61. The book gets a new writer, the team gets a new member and Bek goes on a date with his wife and her boyfriend.
OMG HIIII! We missed you! This episode has ev-ah-ree-thing: Benny dressed to the nines reminding us she's too good to be here, fake drugs and trash people, super detective do-si-do, Gabe loves The Happening, RIP Boston Rob, Hellooooo CSU Burt Trevor Bomb Squad Lab Tech, a struggling turtle cop with a chip on his shoulder, a super surprise murderer… 0:45 Recap 1:05:27 True Crime Chaser **TW: Rape, murder, abuse of power by police** Thank you to our Dedicated Detective Patrons: Lydia, Sabrina P, Tricia S, Kati M, LEM, Josh H, Lauren S, Erin D, Natalie S, Robin S, Lea O, Jocelyn and Lyz C And to our Elite Squad Patrons: Hayley K, Sonja W, Skye K, Nikki B, Marisa M, Elke H, Sarah A, Annie G, Mary D, Andrew, Rebekah D, Miranda B, Shelby W, Lex, Emily T, Kayla W, Mallorie G, Eliza W, Bonita R, Maren, Vanessa, Amy P, Jess M, Summer M, Melanie G, Courtney W, Ursula S, Emily A, Katrina C, Kate H and Uyanga We LOVE YOU and APPRECIATE YOU!! You are all making it possible for us to continue doing this!
The Sunday Times' tech correspondent brings on James Peyer, co-founder of Cambrian Biopharma, to talk about the unique structure of his startup (6:30), the goal (8:45), alighting on longevity as a 15-year-old (12:45), why the field has matured (15:40), what he chooses to focus on (19:50), getting drugs to market (24:55), raising money (32:00), why he chose the name (38:30), why dying of old age not necessarily an evolutionary inevitability (41:00), and the vaccine model (45:00), See acast.com/privacy for privacy and opt-out information.
Dr. James Peyer, PhD, is the Founder and CEO of Cambrian Biopharma, a Distributed xDevelopment Company developing therapeutics targeting the biological drivers of aging. Cambrian Biopharma brings together experts, scientists, and experienced company builders in a new model of entrepreneurship related to health span and aging. Dr. Peyer was previously the founder of Apollo Ventures, a successful venture capital firm focused on the longevity biotech space. He has spoken on the topic of longevity biotech and investing for Bloomberg, The Economist, TEDx, Longevity Leaders, ETH Zurich, and the Max Planck Institute on the Biology of Aging. Today, Dr. Peyer joins host Chris Patil to discuss venture capitalism in the longevity space and the new models that are changing the game. After discussing his previous experiences with VC, Dr. Peyer introduces the Distributed Development Company (DISCO) model, which allows scientists to partner with an umbrella company (like Cambrian) instead of selling their discovery to a pharma company. He explains how this model allows investors to support scientists through the whole process of drug development, from initial idea to commercialization, while prioritizing the quality of the science above everything else. Dr. Peyer then goes on to give some details about Cambrian's success so far and how it sources and supports up-and-coming talent in the longevity field. He finishes up by making some predictions about the future of biotech companies and how the DISCO model will have a big role to play. In this episode, you'll learn about venture capitalism's role in scientific discovery and development and why Dr. Peyer believes a new model is necessary to remove the inefficiencies in the current process. Episode Highlights: · Dr. Peyer's experience with Apollo Ventures and why he's moved on to Cambrian Biopharma · The future of the longevity space will come in two stages: reusing insights into what makes us age to build drugs for today, and using those safe and effective drugs to slow down the rate of aging in healthy people · In the long run, company-based models will be better than fund-based ones for the longevity space · The Distributed Development Company model (aka DISCO) · Cambrian started with three programs and has scaled up to over fourteen in two years · Cambrian prioritizes the quality of the science over hype · Cambrian has raised about $160 million since 2019, including $100 million Series C financing at the end of October · Cambrian sources talent through constant monitoring of the scientific field · The DISCO model was designed to correct inefficiencies in the process of getting funding for scientists and their discoveries · Drug development is a risky process, and Cambrian ensures success by carefully monitoring progress at every stage · Being a bona fide longevity biotech organization means being willing to support every single program from funding to commercialization · There are opportunities to partner with big pharma companies, but commitment to the whole process is the default · Cambrian's two publicly-disclosed programs are with Vita Therapeutics, a cell engineering company run out of Johns Hopkins · One of the advantages Cambrian can provide to scientists is the ability to keep their discoveries as trade secrets as long as possible to maximize their patent lifespan · The potential for the DISCO model to be used in other fields beyond longevity · The possibility of failure and how Cambrian works to avoid it by being realistic and strategic and bringing expertise on board · DISCO works really well for asset-centric breakthroughs made by very small companies or at universities, but it's not the catch-all solution for everything—for example, tech platforms may be a better choice for bigger biotechs,
The Wrong Earth, written by Tom Peyer, is a comics series in which the super-square Dragonflyman and grim & gritty Dragonfly find themselves on each other's versions of earth. In the second volume, recently concluded, the two meet each other on yet another earth. Peyer, editor-in-chief at Ahoy Comics, is an industry veteran with many writing credits under his belt, including for the Batman '66 comics series. This time, Tom joins us to discuss our favorite show and what The Wrong Earth might tell us about it. PLUS: The Bobby Valentin version of the theme (another bugaloo!), Burt Ward on Batman shooting locations, and your mail about our Curse of Tut script discussion! Batman v Superman trailer spoof
An impromptu conversation about the recent murder of Sarah Everard and how it relates to violent crimes perpetrated by police in America. California True Crime discusses the issues that have been highlighted by this murder and connections to the Cara Knott case covered in an earlier episode, as well as some startling statistics on the rates of violence against women by police officers in uniform and some of the systemic issues that are in place that act as a roadblock to studying, and ultimately stopping these types of crimes. https://www.nbcnews.com/think/opinion/sarah-everard-case-shows-society-s-rules-women-don-t-ncna1261298Website and show notes: http://www.californiatruecrime.comIf you would like to support us we have a Patreon page at: https://www.patreon.com/californiatruecrimeFacebook: https://www.facebook.com/calitruecrimeTwitter: https://twitter.com/calitruecrimeInstagram: https://www.instagram.com/calitruecrime
We hope you’re ready for some ‘66 shenanigans Bat-Fanatics! This week Joe & Kendal are joined by special guest Megan to delve into the second volume of the Batman ‘66 comic series. They covered the first volume way back in episode 29! The second volume focuses on many of the one-arc villains from the series, plus two VERY unexpected returns: Eggbert & Lisa Carson (Lisa was part of our King Tut discussion in Episode 46). Do these stories hold up to the first volume? Do they still capture the “vibe” of Batman ‘66? More importantly… will Bookworm discover the secret identity of Batman? How many women will try to marry Batman/Bruce Wayne? How do identical cousins work? Listen in and find out! ** This episode was recorded after Return of the Joker, so the ongoing “plot” of Season 3 will be slightly out of order. Don’t let your back get Bane’d! It’s bad for podcast continuity ** Plot Pandemonium - Batman ‘66 vol. 2: Physical Issues #6 - 10, Digital Issues #16 - 30
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James Peyer, PhD is the Founder and CEO of Cambrian Biopharma -- far ranging discussion about aging and the future of death --- Send in a voice message: https://anchor.fm/johnb/message
Murder + Horrific = Murderific.This episode was also sponsored by Best Fiends. Find this app in the Apple App Store or Google Play!This episode covers the 1986 San Diego murder of Cara Evelyn Knott, who was driving at night to get to her family home. The murder was devastating enough. More shocking was who the killer turned out to be.Executive Producers: Kristina B., Mike T. and Beth Ann L.Promo: Crime and Compulsion Podcast (instagram @crimeandcompulsionpodcast)Contact Us:murderificpodcast@gmail.comCall 1-207-200-8813 to leave a voice message for us which we may play on the air!Patreon:https://www.patreon.com/join/murderificpodcast?/Buy Me a Coffee:https://www.buymeacoffee.com/murderific Sources:https://en.wikipedia.org/wiki/Murder_of_Cara_Knotthttps://www.latimes.com/archives/la-xpm-1988-02-09-me-41439-story.htmlhttps://www.nbcsandiego.com/news/local/craig-peyer-parole-hearing-cara-knott/1950023/https://www.10news.com/news/local-news/san-diego-news/cara-knotts-family-fears-her-killer-could-be-releasedhttps://www2.palomar.edu/users/ddozier/course_notes/concepts/isms/uniforms%20and%20authority%20Cara%20Knott.htmhttps://people.com/archive/a-california-highway-patrolman-is-tried-once-again-for-a-shocking-murder-under-the-freeway-vol-29-no-23/https://uaptsd.org/2014/12/27/the-tragic-story-of-cara-knott-murdered-by-chp-officer-peyer-in-san-diego/https://caselaw.findlaw.com/ca-court-of-appeal/1771858.htmlhttps://loriajohnston.medium.com/the-murder-of-cara-knott-at-the-hands-of-a-chp-officer-6a382867996bhttps://www.sandiegouniontribune.com/news/public-safety/sd-me-knott-verdict-anniversary-20180621-story.htmlAUDIO SOURCEShttps://youtu.be/1THugbmpvkYhttps://youtu.be/CRclJ6ATObQ
On 3 March, Rishi Sunak will deliver his second Budget – almost a year on from the moment the government took the unprecedented step last spring to lockdown the country. With a third lockdown still in place, how will the chancellor deliver on Boris Johnson’s promise that the government will “continue to do whatever it takes to protect jobs and livelihoods across the UK”? What will the Budget do to support economic recovery once the lockdown is lifted? And will this Budget tell us anything about Sunak’s longer term ambitions for tax, spending, borrowing and debt?In this edition of Inside Briefing Extra, IfG Chief Economist Gemma Tetlow is joined by former special advisor Will de Peyer, IfG senior economist Tom Pope, and IfG senior fellow Giles Wilkes.Audio production by Candice McKenzie#IfGBudget2021 See acast.com/privacy for privacy and opt-out information.
James Peyer, PhD is the Founder and CEO of Cambrian Biopharma, a Distributed Drug Discovery Company developing therapeutics targeting the biology of aging. Cambrian builds, finances, and manages a pipeline of therapeutics. In this conversation, we discuss the nine hallmarks of aging, molecular damage, how to add healthy years to your life, prevention vs reversal of diseases, and distributed drug companies. ======================= Exodus is an absolute game changer in the crypto wallet space, and we’ve teamed up to offer an exclusive discount for you, as listeners of the podcast. Sign up for Exodus today using my promo code http://exodus.com/pomp This is a no brainer for both newcomers and crypto heavyweights - go sign up today. ======================= With over 5 Million users, Crypto.com is the easiest way to buy, and sell over 90 cryptocurrencies. Download the app at Crypto.com and get $25 with my code: POMP. When it’s time to spend your crypto, nothing beats the Crypto.com Visa Card, which pays you up to 8% back instantly, with no annual, or monthly fees to worry about! Get $25 when you download the Crypto.com App today using the code “POMP” ======================= Download the top-rated DraftKings Sportsbook app NOW and use promo code POMP when you sign up to Hammer the Over on Sunday night’s basketball game when LA takes on Denver. For every ONE THOUSAND people that bet the over in Sunday’s game, the line will decrease by one point. Yes, this is your2 chance to improve the odds of the over hitting, so tell your friends and family, this is a team effort! Hammer the over and improve your odds of doubling your money. That’s promo code POMP.… for a limited time, only at DraftKings Sportsbook! =======================
In this talk, Lorrayn De Peyer shares their knowledge on gaining the courage to turn your passion into a profit. These talks come from the archive of The Best You EXPO. The Best You EXPO talks are live talks recorded at events in London and Los Angeles. The talks are approximately 45 minutes long and cover all aspects of personal and professional growth. Talks on public speaking, finding love, increasing confidence and low self-esteem, how to make more money, get more clients, increase your social media presence, talks on NLP and so much more. We are talking about over 500 talks and more being recorded all over the world, so there is something for everyone.
字数限制，只能展示如下化学（材料）：Triple-halide wide-band gap perovskites with suppressed phase segregation for efficient tandems 三卤化物宽带隙钙钛矿可抑制光诱发的相分离从而达致高效率的叠层光伏电池A droplet-based electricity generator with high instantaneous power density 一种基于液滴的高功率密度发电机Balancing volumetric and gravimetric uptake in highly porous materials for clean energy权衡多孔材料的体积和重量吸附率以获取清洁能源Ultrafast control of vortex microlasers涡旋微激光器的超快控制Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol甲烷氧化制甲醇过程中原位生成过氧化物的疏水沸石改性Transparent ferroelectric crystals with ultrahigh piezoelectricity具有超高压电效应的透明铁电晶体Wafer-scale single-crystal hexagonal boron nitride monolayers on Cu (111)Cu (111)上的 wafer 规模的单晶六方氮化硼单层Mott and generalized Wigner crystal states in WSe2/WS2 moire superlatticesWSe2/WS2云纹超晶格中的 Mott 和广义 Wigner 晶体态Fully hardware-implemented memristor convolutional neural network完全硬件实现的记忆电阻卷积神经网络Asynchronous carbon sink saturation in African and Amazonian tropical forests非洲和亚马逊热带森林碳汇饱和度异步Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc脂质纳米盘中 M2毒蕈碱受体 -β- 抑制素复合物的结构Design of robust superhydrophobic surfaces坚固的超疏水表面的设计General synthesis of two-dimensional van der Waals heterostructure arrays二维 van der Waals 异质结构阵列的一般合成Accelerated discovery of CO2 electrocatalysts using active machine learning使用主动机器学习加速发现二氧化碳电催化剂Observation of hydrogen trapping at dislocations, grain boundaries, and precipitates在位错，晶界和沉淀处观察氢捕获Seeking new, highly effective thermoelectrics寻找新的高效热电偶Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice二维六角冰的边缘结构和生长的原子成像Li metal deposition and stripping in a solid-state battery via Coble creep利用 Coble 蠕变技术在固态电池中沉积和剥离 Li 金属Single-particle spectroscopy for functional nanomaterials功能性纳米材料的单粒子光谱学Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass再生大块金属玻璃的应变硬化及剪切带抑制天文物理Quantum anomalous Hall effect in intrinsic magnetic topological insulator MnBi2Te4内禀磁性拓扑绝缘体 MnBi2Te4中的量子反常霍尔效应Tunable correlated Chern insulator and ferromagnetism in a moire superlattice莫瓦超晶格中的可调相干陈氏绝缘体及铁磁性A single photonic cavity with two independent physical synthetic dimensions具有两个独立物理合成尺寸的单光子腔Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor铁基超导体涡旋零模的近量子化电导平台One-dimensional van der Waals heterostructures一维 van der Waals 异质结构The water lily genome and the early evolution of flowering plants睡莲基因组与被子植物的早期进化Conversion of non-van der Waals solids to 2D transition-metal chalcogenides非 van der Waals 固体向二维过渡金属硫族化合物的转化Assessing progress towards sustainable development over space and time评估跨越时空实现可持续发展的进展情况Localization and delocalization of light in photonic moire lattices光子莫尔晶格中光的定位和离域Entanglement of two quantum memories via fibres over dozens of kilometres通过几十公里长的光纤纠缠两个量子存储器A planet within the debris disk around the pre-main-sequence star AU Microscopii在主序前星 AU Microscopii 周围的碎片盘内的行星Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics用于高性能电子学的定向高密度半导体碳纳米管阵列Entanglement-based secure quantum cryptography over 1,120 kilometres基于纠缠的安全量子密码学超过1120公里Photocurrent detection of the orbital angular momentum of lightPhotocurrent 检测光的轨道角量子数Quantum entanglement between an atom and a molecule原子与分子之间的量子纠生理学或医学Pan-cancer analysis of whole genomes全基因组泛癌分析生理学或医学Analyses of non-coding somatic drivers in 2,658 cancer whole genomes2,658个癌症全基因组中非编码体细胞驱动因子的分析生理学或医学Genomic basis for RNA alterations in cancer癌症 RNA 改变的基因组学基础生理学或医学Single-Cell Transcriptome Atlas of Murine Endothelial Cells鼠内皮细胞的单细胞转录组图谱生理学或医学Gasdermin E suppresses tumour growth by activating anti-tumour immunityGasdermin e 通过激活抗肿瘤免疫抑制肿瘤生长生理学或医学N-6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription染色体相关调控 RNA 的 n-6- 甲基腺苷调控染色质状态和转录生理学或医学Construction of a human cell landscape at single-cell level构建单细胞水平的人类细胞景观生理学或医学The genetic architecture of the human cerebral cortex人类大脑皮层的遗传结构生理学或医学Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis过氧化氢传感器 HPCA1是拟南芥(Arabidopsis)中的 LRR 受体激酶生理学或医学Microglia mediate forgetting via complement-dependent synaptic elimination小胶质细胞通过补体依赖性突触消除介导遗忘生理学或医学Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense肠支配伤害感受神经元调节 Peyer's Patch Microfold 细胞和 SFB 水平介导沙门氏菌宿主防御生理学或医学A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1由 RIPK1的不可切割变体引起的显性自身炎症性疾病生理学或医学
字数限制，只能展示如下化学（材料）：Triple-halide wide-band gap perovskites with suppressed phase segregation for efficient tandems 三卤化物宽带隙钙钛矿可抑制光诱发的相分离从而达致高效率的叠层光伏电池A droplet-based electricity generator with high instantaneous power density 一种基于液滴的高功率密度发电机Balancing volumetric and gravimetric uptake in highly porous materials for clean energy权衡多孔材料的体积和重量吸附率以获取清洁能源Ultrafast control of vortex microlasers涡旋微激光器的超快控制Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol甲烷氧化制甲醇过程中原位生成过氧化物的疏水沸石改性Transparent ferroelectric crystals with ultrahigh piezoelectricity具有超高压电效应的透明铁电晶体Wafer-scale single-crystal hexagonal boron nitride monolayers on Cu (111)Cu (111)上的 wafer 规模的单晶六方氮化硼单层Mott and generalized Wigner crystal states in WSe2/WS2 moire superlatticesWSe2/WS2云纹超晶格中的 Mott 和广义 Wigner 晶体态Fully hardware-implemented memristor convolutional neural network完全硬件实现的记忆电阻卷积神经网络Asynchronous carbon sink saturation in African and Amazonian tropical forests非洲和亚马逊热带森林碳汇饱和度异步Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc脂质纳米盘中 M2毒蕈碱受体 -β- 抑制素复合物的结构Design of robust superhydrophobic surfaces坚固的超疏水表面的设计General synthesis of two-dimensional van der Waals heterostructure arrays二维 van der Waals 异质结构阵列的一般合成Accelerated discovery of CO2 electrocatalysts using active machine learning使用主动机器学习加速发现二氧化碳电催化剂Observation of hydrogen trapping at dislocations, grain boundaries, and precipitates在位错，晶界和沉淀处观察氢捕获Seeking new, highly effective thermoelectrics寻找新的高效热电偶Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice二维六角冰的边缘结构和生长的原子成像Li metal deposition and stripping in a solid-state battery via Coble creep利用 Coble 蠕变技术在固态电池中沉积和剥离 Li 金属Single-particle spectroscopy for functional nanomaterials功能性纳米材料的单粒子光谱学Strain-hardening and suppression of shear-banding in rejuvenated bulk metallic glass再生大块金属玻璃的应变硬化及剪切带抑制天文物理Quantum anomalous Hall effect in intrinsic magnetic topological insulator MnBi2Te4内禀磁性拓扑绝缘体 MnBi2Te4中的量子反常霍尔效应Tunable correlated Chern insulator and ferromagnetism in a moire superlattice莫瓦超晶格中的可调相干陈氏绝缘体及铁磁性A single photonic cavity with two independent physical synthetic dimensions具有两个独立物理合成尺寸的单光子腔Nearly quantized conductance plateau of vortex zero mode in an iron-based superconductor铁基超导体涡旋零模的近量子化电导平台One-dimensional van der Waals heterostructures一维 van der Waals 异质结构The water lily genome and the early evolution of flowering plants睡莲基因组与被子植物的早期进化Conversion of non-van der Waals solids to 2D transition-metal chalcogenides非 van der Waals 固体向二维过渡金属硫族化合物的转化Assessing progress towards sustainable development over space and time评估跨越时空实现可持续发展的进展情况Localization and delocalization of light in photonic moire lattices光子莫尔晶格中光的定位和离域Entanglement of two quantum memories via fibres over dozens of kilometres通过几十公里长的光纤纠缠两个量子存储器A planet within the debris disk around the pre-main-sequence star AU Microscopii在主序前星 AU Microscopii 周围的碎片盘内的行星Aligned, high-density semiconducting carbon nanotube arrays for high-performance electronics用于高性能电子学的定向高密度半导体碳纳米管阵列Entanglement-based secure quantum cryptography over 1,120 kilometres基于纠缠的安全量子密码学超过1120公里Photocurrent detection of the orbital angular momentum of lightPhotocurrent 检测光的轨道角量子数Quantum entanglement between an atom and a molecule原子与分子之间的量子纠生理学或医学Pan-cancer analysis of whole genomes全基因组泛癌分析生理学或医学Analyses of non-coding somatic drivers in 2,658 cancer whole genomes2,658个癌症全基因组中非编码体细胞驱动因子的分析生理学或医学Genomic basis for RNA alterations in cancer癌症 RNA 改变的基因组学基础生理学或医学Single-Cell Transcriptome Atlas of Murine Endothelial Cells鼠内皮细胞的单细胞转录组图谱生理学或医学Gasdermin E suppresses tumour growth by activating anti-tumour immunityGasdermin e 通过激活抗肿瘤免疫抑制肿瘤生长生理学或医学N-6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription染色体相关调控 RNA 的 n-6- 甲基腺苷调控染色质状态和转录生理学或医学Construction of a human cell landscape at single-cell level构建单细胞水平的人类细胞景观生理学或医学The genetic architecture of the human cerebral cortex人类大脑皮层的遗传结构生理学或医学Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis过氧化氢传感器 HPCA1是拟南芥(Arabidopsis)中的 LRR 受体激酶生理学或医学Microglia mediate forgetting via complement-dependent synaptic elimination小胶质细胞通过补体依赖性突触消除介导遗忘生理学或医学Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense肠支配伤害感受神经元调节 Peyer's Patch Microfold 细胞和 SFB 水平介导沙门氏菌宿主防御生理学或医学A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1由 RIPK1的不可切割变体引起的显性自身炎症性疾病生理学或医学
Issue 62 of Pull Or Pass! Pull Or Pass is your weekly geeky comic book show! Hosted by Angela, Matt, Will & Zach and available on the We Made This Podcast Network every weekend! In this week's Manchester Comic Book Club tie-in episode Will and Zach discuss The Wrong Earth by Tom Peyer and Jamal Igle from Ahoy Comics! When Dragonfly and Dragonflyman - the same hero from alternate realities - find themselves trading places how will they adapt to their new surroundings and place in these new worlds! Features: • Trade review of The Wrong Earth! Hosts: Zach Whittaker & Will Holden Editor: Zach Whittaker Twitter: @PullOrPass We Made This on Twitter: @wemadethispod www.pullorpass.wordpress.com www.wemadethispod.com
1.Id proteins are helix-loop-helix (HLH) proteins lacking the basic amino acid domain necessary to bind DNA.and therefore ID functions in a dominant negative manner by sequestering ubiquitously expressed or cell- restricted basic HLH transcription factors: this results in effective blockade of transcription since ID causes a failure of dimerized basic HLH proteins to bind DNA. 2. Id proteins regulate transcription factors that are involved in developmental processes such as myogenesis, neurogenesis, bone morphogenesis, lymphopoiesis hematopoiesis, and myeloid differentiation 3. Id2−/− mice lack lymph nodes and Peyer's patches*, *Peyer's patches are discrete masses of lymphatic tissue found throughout the ileum of the mammalian small intestine Oncogene volume 22, pages1–9(2003) PNAS January 15, 2019 116 (3) 890-899 SUBSCRIBE and tell a colleague about Authentic Biochemistry And please Donate to my podcast! --- Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support
London-based Fabio Peyer speaks about his role as EMEA senior marketing manager at Morningstar, a financial services firm, in addition to his role as EMEA DEI (Diversity, Equity & Inclusion) Lead for the brand. Fabio talks about the challenges of marketing in traditional industries, and hones in on the notion that connecting and creating understanding internally is just as important as communicating with the public. He also discusses demand generation, leveraging multichannel marketing to meet your customers where they are, and the necessity of diversity and inclusion in the workplace.
VP of Student Services Dr. Patrick Peyer takes us on a historical journey detailing his career path and passion for on-boarding students into college life. Find out what it takes to create "golden moments" for new students and learn about his leadership philosophy and orientation strategies. He also shares what class he wants to take at RVC when he finds the time.
On the evening of December 27, 1986, Cara Knott, a San Diego State university student who was studying to become a teacher, was leaving her boyfriend's house in Escondido around 9:00pm and driving to her parents house in El Cajon. She will never make it. Join us as we discuss this horrible tragedy from the southern part of California. Website and show notes: http://www.californiatruecrime.com/If you would like to support us we have a Patreon page at: https://www.patreon.com/californiatruecrimeFacebook: https://www.facebook.com/calitruecrime/Twitter: https://twitter.com/calitruecrimeInstagram: https://www.instagram.com/calitruecrime/Link to opening clip: https://www.youtube.com/watch?v=CRclJ6ATObQ
Check out Canna-Talk ND every Thursday 4-5PM on 95.9FM Radio Free Fargo with host Greg Wilson! Subscribe today to join us in the ride that is legalizing Cannabis and passing a constitutional amendment through North Dakota, With the North Dakota Marijuana Legalization Initiative. Anyone over the age of 21 will be able to grow, consume, process 12 plants (6 mature at a time). All Cannabis Businesses will require licensing Facebook: https://www.facebook.com/groups/149559819113746/ Instagram: www.instagram.com/nd_cannabis_caucus Twitter: https://twitter.com/CaucusNd Website: https://ndforfreedom.org For more information about our measure: https://ballotpedia.org/North_Dakota_Legalize_Marijuana_and_Allow_Home_Growth_Amendment_(2020)
Tom Peyer, writer and editor-in-chief at Ahoy Comics, talks about the Dragonfly and Dragonflyman series, a prequel to The Wrong Earth. Two heroes—Dragonfly and Dragonflyman—find themselves on each other's worlds, two places which could not be more different. On gritty Earth-Omega, Dragonfly prowls the darkness for his evil prey; on sun-splashed Earth-Alpha, Dragonflyman protects the status quo. Peyer talks about the two different heroes and the worlds they come from and how each adapts when the big switch happens. We also look at the other titles available from Ahoy and what is coming in the near future.
John's private podcast feed ~ betaworks Studios events & things I'm listening to.. enjoy
Discussion at betaworks Studios Nov 14th --- Send in a voice message: https://anchor.fm/johnb/message
This week's episode of the Phenomenal 50 features a very special performance of Franz Schubert's Der Hirt auf dem Felsen [The Shepherd on the Rock] with soprano Beverly Sills, clarinetist Gervaise de Peyer, and pianist Charles Wadsworth.
Food Scientist, Kriben Govender (Honours Degree in Food Science & Technology) and James Shadrach (Honours Degree in Psychology) have a wide-ranging discussion with Citizen Scientist Keith Bell on Microbiome stool testing, strategies to modulate gut bacterial composition for optimal health, epilepsy, gut-brain axis, rain forming bacteria, the importance of viruses, gut centric remedies for anxiety and depression, microbiota - mitochondria interaction, kefir and much more Bio: Keith Bell is a citizen scientist particularly interested in gut-brain connection including the gut origin of seizure, underdiagnosed in epilepsy. Published articles include topics such as microbial predisposition, fetal colonization, microbe translocation and vaccine safety. He's founder of Sanitation Circle and 25 year veteran of the recycling industry with interest in sanitation and health. During the 1980s, he was a UNICEF radio spokesperson in Chicago for the annual release of State of the World's Children Report. He believes "Sanitation is Sanity" and that microbial balance is an internal and external environmental issue of the highest order. Keith founded The Gut Club in 2016 to create awareness about the importance of intestinal health to general health and provide support for treatment and prevention of metabolic disease. Topics discussed: The Glut Club - the hub of microbiome citizen science Analysis of stool test results Microbiome differences across the world Geography, diet and microbiome diversity Allele Microbiome Stool testing Obesity- Firmicutes and Bacteroidetes The immune response guidance by microbes The function of Peyer’s Patches Vaccine response in high Bacteroides cohort Obesity and Lipopolysaccharides (LPS) Persia the Cradle of Bacteroides Prevotella- Fibre eater Microbiome changes after migration Consequences of a shift from Prevotella to Bacteroides The Gut - Could it be the Environmental Issue of our time The Gut and Epilepsy Rain Making Bacteria and Fungi (see laboratory experiment) https://youtu.be/SenJud3cHLc CO2 sequestering by microbes Exchange breathing method for seizures Diets for Epilepsy Forum The impact of Metformin on the microbiome Bacteriophages (viruses) and early infancy immunity The River Ganges - bacteriophages Personalised medicine via stool test charts Shifting the gut microbiome Autoimmune and Bacteroides dominance Keto, Paleo, Low carb and Carnivore Diet benefits and flora shift The Microbiome and Mental Health Kriben’s struggle with anxiety and depression Environmental factors that cause depression The Gut-Brain Axis The Impact of Stress on Bifidobacteria and Lactobacilli Lactobacilli, Oxytocin and empathy Oxytocin, autism, eye contact and touch Clostridium, serotonin and tryptophan metabolism Amino Acids neurotransmitter balance and microbes Serotonin Syndrome SSRIs Gut, Brain and Heart connection GAPS Diets- Natasha Campbell McBride Kefir Fermentation time and Lactobacillus domination Fibre, Butyrate production, oxygen, microbiome modulation The importance of the mucous layer Acacia, Partially Hydrogen Guar Gum- Prebiotics Inulin and bloating Fasting and Microbiome Composition Gut Club Stool Testing Discussion Group https://www.facebook.com/groups/TheGutClubStoolTestDiscussionGroup/ The citizen science of sharing microbiome stool charts Autism and Stool test results Faecal Microbiome Transplants Probiotic enemas Breastfed baby poop- untapped medicine Infant stool History in China Bacteroides dominance The impact of excess Bifidobacteria and Akkermansia Race, Gender and Geography of Microbiome Diversity Microbiome and Mitochondrion interaction The impact of antibiotics on mitochondria and ROS production Keith’s top gut health tip Microbial modulation of Vitamin D Dr Jack Kruse interview - Light and the Microbiome https://podcast.nourishmeorganics.com.au/dr-jack-kruse-on-light-and-the-microbiome Brought to you by: Nourishme Organics The Gut Health Superstore Shop Gut Health here: https://www.nourishmeorganics.com.au/ Use code guthealthgurus for 10% off Allele Microbiome- Australian Provider of World Leading Metagenomic Whole Genome Stool Testing Learn more about Metagenomic DNA based Stool Testing: https://www.allele.com.au/collections/frontpage/products/gut-microbiome-analysis Connect with Keith Bell Website- https://thegutclub.org/ Connect with Kriben Govender: Facebook- https://www.facebook.com/kribengee/ Instagram- https://www.instagram.com/kribengovender/ Youtube- https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1 Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/ Mito Wellness Support Facebook Group: https://www.facebook.com/groups/347845406055631/ Download links If you enjoyed this episode and would like to show your support: 1) Please subscribe on Itunes and leave a positive review Instructions: - Click this link https://itunes.apple.com/au/podcast/gut-health-gurus-podcast/id1433882512?mt=2 - Click "View in Itunes" button on the left-hand side - This will open the Itunes app - Click the "Subscribe" button - Click on "Ratings and Reviews" tab - Click on "Write a Review" button Non-Itunes users can leave a Google Review here: https://goo.gl/9aNP0V 2) Subscribe, like and leave a positive comment on Youtube https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1 3) Share your favourite episode on Facebook, Instagram, and Stories 4) Let your friends and family know about this Podcast by email, text, messenger etc 5) Support us on Patreon for as little as $5 per month and get same day, early access to our latest podcasts (typically around 4 to 6 weeks earlier than the general public) https://www.patreon.com/nourishmeorganics Thank you so much for your support. 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In today's podcast episode, we unpack all things amino acids... "...Five months after beginning the amino acids, I achieved a personal best at Ironman Canada, in Penticton B.C. In my new and improved physical state, I began to wonder if my vegetarian, protein- deficient diet was the reason why the anti-cancer enzymes scorched my stomach. Could it be that the mucous lining in my stomach was inadequate, and that had also held back the healing of my hamstring? I very badly wanted to find out, so I decided to try the enzymes again. I followed the full protocol, twelve tablets, six times per day for three consecutive days. I had no adverse reactions, and my stomach was fine. I learned that because my overall body protein levels had normalized, the mucous layer in my stomach was better able to handle the enzymes. What a revelation! I thought, could this also be a key problem with my patients and their various conditions? " Thus begins the new book "The Search For The Perfect Protein", by 42 time Ironman triathlete Dr. David Minkoff. Dr. Minkoff graduated from the University of Wisconsin Medical School in 1974 and was elected to the “Phi Beta Kappa” of medical schools, the prestigious Alpha Omega Alpha Honors Medical Fraternity for very high academic achievement. He then completed both a Pediatric Residency and Fellowship in Infectious Disease at the University of California at San Diego. He worked at the University of California and Children's Hospitals in San Diego as an attending physician in infectious disease while conducting original research on Ribaviron, a broad spectrum anti-viral agent to fight disease. He also co-directed a neo-natal intensive care unit and worked in emergency medicine. In 1995, his wife became ill, and her physicians couldn't find what was wrong. Not accepting their "no hope" conclusion, Dr. Minkoff went on a search to help her that led him out of emergency medicine into complementary and alternative medicine to find the answers. In the process he gained expertise in Biological medicine, heavy metal detoxification, anti-aging medicine, hormone replacement therapy, functional medicine, energy medicine, neural and prolotherapy, homeopathy and optimum nutrition. He studied under the masters in each of these disciplines until he became an expert in his own right. The answers he found were soon in demand when others learned of his wife’s return to good health. In response to this, he and his wife, Sue Minkoff RN established Lifeworks Wellness Center in 1997 and it quickly became one of the most comprehensive complementary and alternative medicine clinics in the U.S. The demand for the products and protocols he discovered became a catalyst for founding BodyHealth.Com, a nutrition company that now manufactures and distributes these cutting-edge solutions for the many health problems today. Dr. Minkoff writes two free online newsletters, “The Optimum Health Report” and ”The BodyHealth Fitness Newsletter”, to help others learn about optimum health and fitness. In my conversation with Dr. Minkoff, you'll learn... -Dr. Minkoff's history with amino acids and why he wrote his new book... The science behind amino acids and protein wasn't keeping up with the commercial PR and marketing Strained a hamstring while running an Ironman triathlon in 1982 Tried everything possible to no avail Tried amino acids and felt no pain, no discomfort Max heart rate rose by 12 bpm Muscle and bone tissue filled in A patient who was familiar with natural cancer treatment recommended a pancreatic enzyme treatment; had very negative results He then supplemented it with essential amino acids and was perfectly fine Saw potential cure for other problems patients may be having (that are not cancer) He realized that if it was effective for him, it would be beneficial for others He now sees amino acids as an essential element of a workout and proper recovery Vegans and vegetarians are notoriously deficient in aminos, B12, Iron and other nutrients Highly recommend an Amino supplement -About CHYMO, the thyroid and its interaction with amino acids... Chymotrypsin: an enzyme made in the pancreas that is necessary to digest food Actin: the main protein in muscle; Contains 5800 different amino acids in one chain of the muscle fiber Must be broken down into individual amino acids in order for the intestine to absorb it Vicious cycle: amino acids not enough to make chymotrypsin; can't digest protein properly; amino acids can't get into the bloodstream Many people are iodine deficient Also low in tyrosine (made from the essential amino acid phenylalanine) These are common issues -The link between amino acids/proteins and the gut and digestion... The inner lining of the intestine is one cell thick Leaky barrier membranes: your body gets exposed to foreign proteins 70-80% of your immune system is behind the membrane barrier (Peyer's patches, gut associated lymphoid tissue) Inner lining of the gut has a high turnover (every 3-5 days) due to the exposure, wear and tear, etc. Leakage occurs when these membranes are not replaced Lack of amino acids slows the turnover rate (10-12 days) Endurance training compromises the immune system due to the pounding on the body -How amino acids are used by riders in the Tour de France bike race... Podcast: w/ Dr. Jeff Spencer Dr. Spencer is a former Olympic biker who worked for the U.S. team during the Lance Armstrong era Minkoff gave Spencer amino acids to give to the riders during one of the races: After 21 days, athletes are broken down, even with optimal nutrition, medical care, etc. Athletes who used amino acids didn't break down; performance improved Athletes and coaches overwork and don't allow adequate recovery time; results in a broken immune system -Why not derive amino acids from whey protein, spirulina and other sources?... The amount of protein listed on the package doesn't translate to amounts in other sources (fish, steak, spirulina, etc.) Medication to stop stomach acid stops protein digestion Pepsin enzyme which digests protein requires a very acid stomach Cells have two pathways with which to deal with the amino acids: Anabolic: Turns amino acids into the proteins the cell is responsible for (hair, liver, muscle etc.) Catabolic: Nitrogen becomes a waste product; chain leftover looks like a carbohydrate Ratio of essential amino acids in Kion Aminos is very specific; the body will use amino acids into making protein Spirulina is good for some things; amino acids is not one of them Adding non-essential amino acids decreases the efficacy of the product Collagen has 50% non-essential amino acids -The chemical configurations of amino acids... The body can only use the "left-handed" configuration (L form) Most amino acid forms have very low amino acid utilization because they include the R form -How amino acids work with fasting and/or ketosis... You can take amino acids and not spike blood glucose levels Excessive proteins will kick you out of fasting is a myth Amino acids work very well for fasting in an anabolic state 10 g of amino acids is 4 calories (less than a stick of gum) -How safe amino acids are for children... -And much more... Resources from this episode: - - - - - - - - Podcast: - Podcast: - Podcast: - Podcast: w/ Dr. Jeff Spencer Episode Sponsors: -: Building blocks for muscle recovery, reduced cravings, better cognition, immunity, and more. Get 10% off your order of Kion Aminos, and everything at the Kion site when you use discount code "bgf10" at checkout. -: After using the Joovv for close to 2 years, it's the only light therapy device I'd ever recommend. Give it a try: you won't be disappointed. Order using and receive a nice bonus gift with your order! -: Try the shaving company that’s fixing shaving. Get a $13 value trial set that comes with everything you need for a close, comfortable shave when you go to -: Quality is our Gimmick isn’t just our slogan, it’s a commitment we honor with every stitch we sew. 100% money back guarantee. Get 10% off your order, PLUS free shipping on any order over $99 when you use discount code: BENG. Do you have questions, thoughts or feedback for Dr. Minkoff or me? Leave your comments below and one of us will reply!
The 25th Radio episode released as a podcast! Listen In as we discuss a ton of stuff with Ahoy Comics Editor In Chief Tom Peyer. From his days writing books such as Hourman and The Authority, through his editing gigs at Vertigo and more, this guy has been present in some important moments in the history of comics. Now he is in charge of a whole new publisher with a great group of of creators on rad projects, Ahoy! Please check this show out, but more importantly, start digging into The Pint approved selection of books that the folks at Ahoy are putting out, they are flat out fun storytelling at it's best.
James Peyer is the founder and managing partner of Apollo Ventures, an early stage life science investment fund investing in Europe and the U.S. focused exclusively on breakthrough therapeutics arising from the study of the biology of aging. Apollo founds companies with scientists, invests in early stage therapeutics projects, and works with scientific teams to build biotech companies. The company invests in core technologies that show promise in reversing aging and extending human lifespan.“My whole group thinks of ourselves as scientists first and investors second, and so we really get super, super excited about a specific mechanism of action or a cool new way to develop a drug or a way to target aging,” James says. “That's kind of the hook that brings us into a project much more than some of the traditional financial metrics.”He also gives talks all over the world on the topic of aging, discussing how our newfound knowledge of what makes us age will enable the greatest medical breakthroughs of the 21st century.In this episode of Bulletproof Radio, we talk about what venture capital has to do with aging and why it matters that deep investments are being made in the arena of longevity. We touch on bio-freedom, as well as how working intentionally within a system can persuade skeptics and change the world. We cover a lot of ground, including the population effects of longevity, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, altered intercellular communication, mitochondrial dysfunction and more.
James Peyer is the founder and managing partner of Apollo Ventures, an early stage life science investment fund investing in Europe and the U.S. focused exclusively on breakthrough therapeutics arising from the study of the biology of aging. Apollo founds companies with scientists, invests in early stage therapeutics projects, and works with scientific teams to build biotech companies. The company invests in core technologies that show promise in reversing aging and extending human lifespan.“My whole group thinks of ourselves as scientists first and investors second, and so we really get super, super excited about a specific mechanism of action or a cool new way to develop a drug or a way to target aging,” James says. “That's kind of the hook that brings us into a project much more than some of the traditional financial metrics.”He also gives talks all over the world on the topic of aging, discussing how our newfound knowledge of what makes us age will enable the greatest medical breakthroughs of the 21st century.In this episode of Bulletproof Radio, we talk about what venture capital has to do with aging and why it matters that deep investments are being made in the arena of longevity. We touch on bio-freedom, as well as how working intentionally within a system can persuade skeptics and change the world. We cover a lot of ground, including the population effects of longevity, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, altered intercellular communication, mitochondrial dysfunction and more.
This week the guys are joined by 2 of comics great creators Tom Peyer and Cullen Bunn. Peyer enters the Fortress to chat about all things Ahoy Comics, and Bunn joins us to talk about his new kickstarter campaign. And as always the guys talk about all the news fit to print.Check out Cullen Bunn Presents: A Passage in Black at the link below.https://www.kickstarter.com/projects/cullenbunn/cullen-bunn-presents-a-passage-in-black-gnFortressofComicNews.comYouTube.com/FortressofComicNewsChris twitter @fortresschrisMike twitter @fortressrickerPatreon.com/FortressofComicNewsThanks for watching! Please make sure you subscribe to our channel to stay up to date
Over 60 years of composing, Thea Musgrave is a powerful voice that demand respect around the world. We're taking a deep-dive into her massive library and showcasing her eclectic range including chamber, orchestral, and electronic works. Hosted by Seth Boustead Produced by Dan Goldberg Music Turbulent Landscapes BBC Symphony Orchestra; Osmo Vänskä, conductor Concerto for Orchestra Gervase de Peyer, clarinet; Scottish National Orchestra; Alexander Gibson, conductor Green Scottish Ensemble Impromptu No. 1 Nicolas Daniel, oboe; Emer McDonough, flute
Le monde se trouve face à une crise qui soulève des questions tant sur les plans écologique, économique, social que spirituel. Un changement de cap doit être pensé pour construire le monde de demain, une transformation à laquelle nous pouvons toutes et tous contribuer. Depuis des années, des ONG, des Conférences placées sous l’égide des Nations Unies se mobilisent pour améliorer la situation. Si nous voulons protéger efficacement les droits humains, la nature et le climat, il faut un changement de paradigme. Le film Demain est un des vecteurs qui a montré l’émergence de nouveaux modèles se fondant sur la coopération, afin d’aboutir à la création de nouveaux espaces que pourraient investir les individus et l’environnement. Ancienne avocate à la City de Londres, Sofia de Meyer a développé, de retour en Suisse, une entreprise de demain en produisant les jus Opaline avec des fruits achetés localement ; Sophie Swaton, de l’Université de Lausanne, est spécialiste de différents mouvements économiques alternatifs et auteure d'initiatives concrètes pour faire de l’économie collaborative en Suisse romande ; La discussion sera animée par Chantal Peyer de Pain pour le prochain qui connaît fort bien le fonctionnement ou plutôt le dysfonctionnement de l’économie actuelle et qui propose une contribution positive à la société. Table ronde au Club 44 le 15 mars 2018
LIVE! On the Rocks Radio Show: Where Celebrities & Cocktails Mix! Tonight we welcome six time Emmy Award winner - comedian/actor/writer Bruce Vilanch and Broadway (Hairspray, Cry Baby) and TV's (The Guest Book, One Mississippi) Carly Jibson! With Instagrammer/Travel Blogger Daniel Peyer, Ask the Wise Guy with comedian/adult performer Wesley Woods and guest cohost Michael Ferrera. With your hostess with the mostess, Alexander Rodriguez! Follow us on Twitter/Instagram: @ontherocksonair
On the Rocks: Where Celebrities & Cocktails Mix, LIVE from Sunset Gower Studios: Tonight! We welcome actor Keith Coogan (Toy Soldiers, Don't Tell Mom The Babysitter's Dead) chatting about the 30th Anniversary of his film, Adventures in Babysitting; master photographer Matthew Mitchell; Instagrammer & travel blogger Daniel Peyer; CEO of Tesloop Rahul Sonnad; celebrity interviewer Adam Rothenberg from Call Me Adam with guest cohost Michael Vega. AND your hostess with the mostess, Alexander Rodriguez. Find us Twitter/Instagram: @ontherocksonair
Abdominal pain is common; so are strongly held myths and legends about what is concerning, and what is not. One of our largest responsibilities in the Emergency Department is sorting out benign from surgical or medical causes of abdominal pain. Morbidity and mortality varies by age and condition. Abdominal Surgical Emergencies in Children: A Relative Timeline General Advice Neonate (birth to one month) Necrotizing Enterocolitis Pneumatosis Intestinalis. Essentials: Typically presents in 1st week of life (case reports to 6 months in chronically ill children) Extend suspicion longer in NICU graduates Up to 10% of all cases of necrotizing enterocolitis are in full-term children Pathophysiology is unknown, but likely a translocation of bacteria Diagnosis: Feeding intolerance, abdominal distention Abdominal XR: pneumatosis intestinalis Management: IV access, NG tube, broad-spectrum antibiotics, surgery consult, ICU admission Intestinal Malrotation with Volvulus Essentials: Corkscrew Sign in Malrotation with Volvulus Bilious vomiting (80-100%) in the 1st month; especially in the 1st week May look well initially, then rapidly present in shock Ladd’s bands: abnormally high tethering of cecum to abdominal wall; peristalsis, volvulus, ischemia Diagnosis: History of bilious emesis is sufficient to involve surgeons Upper GI series: corkscrew appearance US (if ordered) may show abnormal orientation of and/or flow to superior mesenteric artery and vein Management: Stat surgical consult IV access, resuscitation, NG tube to decompress (bowel wall perfusion at risk, distention worsens) Hirschprung Disease Essentials: Problem in migration of neural crest cells Aganglionic colon (80% rectosigmoid; 15-20% proximal to sigmoid; 5% total colonic aganglionosis) colon (known as short-segment disease) Poor to no peristalsis: constipation, perforation, and/or sepsis Diagnosis: May be diagnosed early as “failure to pass meconium in 1st 48 hours” In ED, presents as either bowel obstruction or enterocolitis Contrast enema Beware of the toxic megacolon (vomiting, distention, sepsis) Management: Resuscitation, antibiotics, NG tube decompression, surgical consultation; stable patients may need rectal biopsy for confirmation Staged surgery (abdominoperineal pull-through with diverting colostomy, subsequent anastomosis) versus one-stage repair. Infant and Toddler (1 month to 2 years) Pyloric Stenosis Essentials: Hypertrophy of pyloric sphincter; genetic, environmental, exposure factorsString Sign in Pyloric Stenosis. Diagnosis: Hungry, hungry, not-so-hippos; they want to eat all of the time, but cannot keep things down Poor weight gain (less than 20-30 g/day) US: “π–loric stenosis” (3.14); pylorus dimensions > 3 mm x 14 mm UGI: “string sign” Management: Trial of medical treatment with oral atropine via NGT (muscarinic effects decrease pyloric tone) Ramstedt pyloromyotomy (definitive) Intussusception Essentials: Majority (90%) ileocolic; no pathological lead point Small minority (4%) ileoileocolic due to lead point: Meckel’s diverticulum, polyp, Peyer’s patches, Henoch-Schönlein purpura (intestinal hematoma) Diagnosis: Target Sign (Donut Sign). Ultrasound sensitivity and specificity near 100% in experienced hands Abdominal XR may show non-specific signs; used mainly to screen for perforation before reduction Management: Hydrostatic enema: contrast (barium or water-soluble contrast with fluoroscopy) or saline (with ultrasound) Air-contrast enema: air or carbon dioxide (with either fluoroscopy or ultrasound); higher risk for perforation than hydrostatic (1% risk), but generally safer than perforation from contrast Consider involving surgical service early (precaution before reduction) Traditional disposition is admission; controversial: home discharge from ED Young Child and Older (2 years and up) Appendicitis Essentials: Appendicitis occurs in all ages, but rarer in infants. Infants do not have fecalith; rather they have some other anatomic or congenital condition. More common in school-aged children (5-12 years) and adolescents Younger children present atypically, more likely to have perforated when diagnosed. Diagnosis: Non-specific signs and symptoms Often have abdominal pain first; vomiting comes later Location/orientation of appendix varies Appendicitis scores vary in their performance Respect fever and abdominal pain Management: Traditional: surgical On the horizon: identification of low-risk children who may benefit from trial of antibiotics If perforated, interval appendectomy (IV antibiotics via PICC for 4-6 weeks, then surgery) Obstruction SBO. Incarcerated Inguinal Hernia. Essentials: Same pathophysiology and epidemiology as adults: “ABC” – adhesions, “bulges” (hernias), and cancer. Diagnosis: Obstruction is a sign of another condition. Look for cause of obstruction: surgical versus medical Abdominal XR in low pre-test probability CT abdomen/pelvis for moderate-to-high risk; confirmation and/or surgical planning Management: Treat underlying cause NG tube to low intermittent wall suction Admission, fluid management, serial examinations Take these pearls home: Consider surgical pathology early in encounter Resuscitate while you investigate Have a low threshold for imaging and/or consultation, especially in preverbal children Selected References Necrotizing Enterocolitis Neu J, Walker A. Necrotizing Enterocolitis. N Eng J Med. 2011; 364(3):255-264. Niño DF et al. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nature. 2016; 13:590-600. Walsh MC et al. Necrotizing Enterocolitis: A Practitioner’s Perspective. Pediatr Rev. 1988; 9(7):219-226. Malrotation with Midgut Volvulus Applegate KE. Intestinal Malrotation in Children: A Problem-Solving Approach to the Upper Gastrointestinal Series. Radiographics. 2006; 26:1485-1500. Kapfer SA, Rappold JF. Intestinal Malrotation – Not Just the Pediatric Surgeon’s Problem. J Am Coll Surg. 2004; 199(4):628-635. Lee HC et al. Intestinal Malrotation and Catastrophic Volvulus in Infancy. J Emerg Med. 2012; 43(1):49-51. Martin V, Shaw-Smith C. Review of genetic factors in intestinal malrotation. Pediatr Surg Int. 2010; 26:769-781. Nehra D, Goldstein AM. Intestinal malrotation: Varied clinical presentation from infancy through adulthood. Surgery. 2010; 149(3):386-391. Hirschprung Disease Amiel J, Sproat-Emison E, Garcia-Barcelo M, et al. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet 2008; 45:1. Arshad A, Powell C, Tighe MP. Hirschsprung's disease. BMJ 2012; 345:e5521. Aworanti OM, McDowell DT, Martin IM, Quinn F. Does Functional Outcome Improve with Time Postsurgery for Hirschsprung Disease? Eur J Pediatr Surg 2016; 26:192. Clark DA. Times of first void and first stool in 500 newborns. Pediatrics 1977; 60:457. Dasgupta R, Langer JC. Evaluation and management of persistent problems after surgery for Hirschsprung disease in a child. J Pediatr Gastroenterol Nutr 2008; 46:13. De Lorijn F, Reitsma JB, Voskuijl WP, et al. Diagnosis of Hirschsprung's disease: a prospective, comparative accuracy study of common tests. J Pediatr 2005; 146:787. Doig CM. Hirschsprung's disease and mimicking conditions. Dig Dis 1994; 12:106. Khan AR, Vujanic GM, Huddart S. The constipated child: how likely is Hirschsprung's disease? Pediatr Surg Int 2003; 19:439. Singh SJ, Croaker GD, Manglick P, et al. Hirschsprung's disease: the Australian Paediatric Surveillance Unit's experience. Pediatr Surg Int 2003; 19:247. Suita S, Taguchi T, Ieiri S, Nakatsuji T. Hirschsprung's disease in Japan: analysis of 3852 patients based on a nationwide survey in 30 years. J Pediatr Surg 2005; 40:197. Sulkowski JP, Cooper JN, Congeni A, et al. Single-stage versus multi-stage pull-through for Hirschsprung's disease: practice trends and outcomes in infants. J Pediatr Surg 2014; 49:1619. Pyloric Stenosis Aspelund G, Langer JC. Current management of hypertrophic pyloric stenosis. Semin Pedaitr Surg. 2007; 16:27-33. Dias SC et al. Hypertrophic pyloric stenosis: tips and tricks for ultrasound diagnosis. Insights Imaging. 2012; 3:247-250. Kawahara H et al. Medical treatment of infantile hypertrophic pyloric stenosis: should we always slice the olive? J Pediatr Surg. 2005; 40:1848-1851. Mack HC. Adult Hypertrophic Pyloric Stenosis. Arch Inter Med. 1959; 104:78-83. Meissner PE et al. Conservative treatment of infantile hypertrophic pyloric stenosis with intravenous atropine sulfate does not replace pyloromyotomy. Pediatr Surg Int. 2006; 22:1021-1024. Mercer AE, Phillips R. Can a conservative approach to the treatment of hypertrophic pyloric stenosis with atropine be considered a real alternative to pyloromyotomy? Arch Dis Child. 2013; 95(6): 474-477. Pandya S, Heiss K, Pyloric Stenosis in Pediatric Surgery.Surg Clin N Am. 2012; 92:527-39. Peters B et al. Advances in infantile hypertrophic pyloric stenosis. Expert Rev Gastroenterol Hepatol. 2014; 8(5):533-541. Intussusception Apelt N et al. Laparoscopic treatment of intussusception in children: A systematic review. J Pediatr Surg. 2013; 48:1789-1793. Applegate KE. Intussusception in Children: Imaging Choices. Semin Roentgenol. 2008; 15-21. Bartocci M et al. Intussusception in childhood: role of sonography on diagnosis and treatment. J Ultrasound. 2015; 18 Gilmore AW et al. Management of childhood intussusception after reductiion by enema. Am J Emerg Med. 2011; 29:1136-1140.:205-211. Chien M et al. Management of the child after enema-reduced intussusception: hospital or home? J Emerg Med. 2013; 44(1):53-57. Cochran AA et al. Intussusception in traditional pediatric, nontraditional pediatric, and adult patients. Am J Emerg Med. 2011; 523-527. Loukas M et al. Intussusception: An Anatomical Perspective With Review of the Literature. Clin Anatomy. 2011; 24: 552-561. Mendez D et al. The diagnostic accuracy of an abdominal radiograph with signs and symptoms of intussusception. Am J Emerg Med. 2012; 30:426-431. Whitehouse et al. Is it safe to discharge intussusception patients after successful hydrostatic reduction? J Pediatr Surg. 2010; 45:1182-1186. Appendicitis Amin P, Chang D. Management of Complicated Appendicitis in the Pediatrc Population: When Surgery Doesn’t Cut it. Semin Intervent Radiol. 2012; 29:231-236 Blakely ML et al. Early vs Interval Appendectomy for Children With Perforated Appendicitis. Arch Surg. 2011; 146(6):660-665. Bundy DG et al. Does This Child Have Appendicitis? JAMA. 2007; 298(4):438-451. Cohen B et al. The non-diagnostic ultrasound in appendicitis: is a non-visualized appendix the same as a negative study? J Pediatr Surg. 2015 Jun;50(6):923-7 Herliczek TW et al. Utility of MRI After Inconclusive Ultrasound in Pediatric Patients with Suspected Appendicitis. AJT. 2013; 200:969-973. Janitz et al. Ultrasound Evaluation for Appendicitis. J Am Osteopath Coll Radiol. 2016; 5(1):5-12. Kanona H et al. Stump Appendicitis: A Review. Int J Surg. 2012; 10:4255-428. Kao LS et al. Antibiotics vs Appendectomy for Uncomplicated Acute Appendicitis. Evid Based Rev Surg. 2013;216(3):501-505. Petroianu A. Diagnosis of acute appendicitis. Int J Surg. 2012; 10:115-119. Mazeh H et al. Tip appendicitis: clinical implications and management. Amer J Surg. 2009; 197:211-215. Puig S et al. Imaging of Appendicitis in Children and Adolescents. Semin Roentgenol. 2008; 22-28. Schizas AMP, Williams AB. Management of complex appendicitis. Surgery. 2010; 28(11):544-548. Shogilev DJ et al. Diagnosing Appendicitis: Evidence-Based Review. West J Emerg Med. 2014; 15(4):859-871. Wray CJ et al. Acute Appendicitis: Controversies in Diagnosis and Management. Current Problems in Surgery. 2013; 50:54-86 Intestinal Obstruction Babl FE et al. Does nebulized lidocaine reduce the pain and distress of nasogastric tube insertion in young children? A randomized, double-blind, placebo-controlled trial. Pediatrics. 2009 Jun;123(6):1548-55 Chinn WM, Zavala DC, Ambre J. Plasma levels of lidocaine following nebulized aerosol administration. Chest 1977;71(3):346-8. Cullen L et al. Nebulized lidocaine decreases the discomfort of nasogastric tube insertion: a randomized, double-blind trial. Ann Emerg Med. 2004 Aug;44(2):131-7. Gangopadhyay AN, Wardhan H. Intestinal obstruction in children in India. Pediatr Surg Int. 1989; 4:84-87. Hajivassiliou CA. Intestinal Obstruction in Neonatal/Pediatric Surgery. Semin Pediatr Surg. 2003; 12(4):241-253. Hazra NK et al. Acute Intestinal Obstruction in children: Experience in a Tertiary Care Hospital. Am J Pub Health Res. 2015; 3(5):53-56. Kuo YW et al. Reducing the pain of nasogastric tube intubation with nebulized and atomized lidocaine: a systematic review and meta-analysis. J Pain Symptom Manage. 2010 Oct;40(4):613-20. . Pediatric Surgery Irish MS et al. The Approach to Common Abdominal Diagnoses in Infants and Children. Pedaitr Clin N Am. 1998; 45(4):729-770. Louie JP. Essential Diagnosis of Abdominal Emergencies in the First Year of Life. Emerg Med Clin N Am. 2007; 25:1009-1040. McCullough M, Sharieff GQ. Abdominal surgical emergencies in infants and young children. Emerg Med Clin N Am. 2003; 21:909-935. Pepper VK et al. Diagnosis and Management of Pediatric Appendicitis, Intussusception, and Meckel Diverticulum. Surg Clin N Am. 2012 This post and podcast are dedicated to Mr Ross Fisher for his passion and spirit of collaboration in all things #FOAMed. Thank you, sir!
Mit vielen seiner Songs hat der Engländer Gordon Matthew Sumner Musikgeschichte geschrieben. Mit seiner Stimme und seinem Bassspiel hat er immerhin einen eigenen Ton gefunden. Das alles und sein Kosename Sting sind seit den späten siebziger Jahren ein Markenzeichen geworden. Im Herbst 2016 erreicht Sting offiziell das Rentenalter. Ans Aufhören und Zurücklehnen denkt er aber mit Sicherheit nicht. Grund genug für eine kritische Rückschau. Der Zürcher Schlagzeuger Marius Peyer ist Gast von Peter Bürli. Erstausstrahlung: 14.06.16
Julia talks with Jana de Peyer, co-founder of Best Friends Animal Sanctuary. in a live conversation from Kanab, Utah. ALSO: Brad and Julia talk about their past and present dogs, and Julia can't stop smacking her lips.
“To vax or not to vax?” Maybe that’s NOT the question… The question of whether or not to vaccinate is an age-old dilemma. There are convincing arguments on both sides, aren’t there? Nobody wants their kids to have to get sick… and by the same token, can we ever really be 100% sure that vaccinations are not going to cause even bigger problems for our children? As frustrating as the lack of long-term research on the subject is, the one thing we can educate ourselves around is exactly how our immune systems work and what we can do to keep them functioning at their best. When we do this, we can be sure that whatever we decide, as pertains to vaccinations, our immune systems have their best fighting chance. You will hear us say again and again that approximately 85-86% of the immune system is located in the gut. It is the beautifully orchestrated system made up of two arms of immunity: the cell-mediated response and the humeral-mediated response—and they both begin in the gut, a porous world between the inside and the outside. T-cells, which are made in the thymus gland, end up inside the gut-associated lymphatic tissue, also known as Peyer’s patches. These things are the police stations of the immune system and are on constant patrol, looking for things that may get through the gut wall and eventually into the bloodstream, causing an immune reaction. Access to the gut is through the mouth. This is no trivial matter. This should be a huge clue as to where our focus needs to be when we’re considering how best to heal and seal the gut, thereby strengthening the immune system. We need to think about what we’re putting into our mouths! The gut absorbs (or doesn’t, depending upon its health) the nutrition we take in through the mouth. I’m going to tell you something that you probably haven’t heard before. And you can consider this a bit of “forbidden” information. Eat what you crave. Should I say that again, just in case it didn’t fully register? Eat what you crave. Now don’t hear what I’m not saying. I am not saying that because you crave Doritos, your body needs Doritos. I’m not saying cheese from a can is a good idea if that’s what you’re craving. Unhealthful cravings need to be dealt with. “Foods” that are barely recognizable as foods do more harm than good and are generally packed with all kinds of sugars, hydrogenated fats, and even neurotoxins like MSG or aspartame. Stay away from that junk! But what I am saying is this: your forbidden doctor is inside you. Your body possesses great wisdom. It knows everything on this Earth. It knows every nutrient. It creates cravings and desires for what it needs for healing, rebuilding and restoring. We crave fat and we crave salt and we crave protein and we crave pork and we crave red meat. We crave all these things that the medical community claims we’re not supposed to be eating. But you will take care of you. As we learn about our body, as we learn that the forbidden doctor inside us, let’s move away from trying to heal from the outside in—with pharmaceuticals and surgeries—and let’s be courageous enough to start that healing process from the inside out. What We Talk About: Why it’s always better to create your own antibodies. Why vaccination is always your choice, but why it’s vital that you’re informed of both sides. Mother nature’s program of going through cell-mediated immunity and why this is so important. Is there really such a thing as a “safer” vaccine? Are you worried that you or your family have already been hit with these tremendous forces, like mercury in your bloodstream? Well, have hope. We have some ideas. Dr. Jack debates Dr. Offit... Why “getting sick” could really be a healthy response. We don’t actually know the effects of vaccines because there are NO long term studies. How many unreported adverse reactions to vaccines are out there? Polio was more than 90% eradicated by the time the polio vaccine showed up... Whatever you do, don’t google “mercury and the brain.” So, what if these vaccination shots don’t kill you, what is the cost? We crave all these things—red meat—we’re not supposed to be eating, if we listen to the medical side. So that’s the beauty of your forbidden doctor inside of you. You will take care of you. Download a transcript of this show! Click Here
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 16/19
The elimination of virus-infected cells to block viral spread is substantially conveyed by effector CD8+ T cells. Trafficking of naïve T cells into the lymph node is a crucial step for their activation to effector T cells. The entry into the lymph nodes is mediated by several cell adhesion molecules that are highly specific for given lymph nodes. For the ingress into the gut-associated lymphoid tissue (GALT) such as mesenteric lymph nodes and Peyer’s patches, the integrin α4β7 is the major homing receptor that interacts with its main ligand MAdCAM-1. On naïve T cells, α4β7 is expressed at low level, however upon activation in the GALT its expression is significantly upregulated on effector T cells. Consequently these effector T cells migrate into the gastrointestinal tract, where MAdCAM-1 is also expressed. The migration patterns of virus-specific CD8+ T cells upon viral infection have been studied in detail. In contrast, the migration of the major population of virus-unspecific CD8+ T cells, i.e. bystander-activated T cells is poorly understood. In our study, we aimed to determine how trafficking of these non-cognate, bystander-activated T cells is affected upon viral infection. We discovered that α4β7 expression was negatively regulated on bystander-activated CD8+ T cells upon injection of poly (I:C), which imitates innate immune activation upon viral infection. This effect was also observed for viral infections such as Sendai, EMCV and the mutant form of VSV virus. Furthermore, we scrutinized the direct role of IFN-α on T cells to exert α4β7 modulation. In the case of EMCV infection, IL-6 played a dominant role in the alteration of α4β7 expression. Finally, using an adoptive transfer model we could prove that the downregulation severely impacted the trafficking of T cells into the Peyer’s patches and to a lesser extent into the mesenteric lymph nodes. These findings demonstrate that a mechanism to regulate trafficking of bystander-activated T cells during viral infection exists and that this is controlled by the induction of cytokines such as IFN-α and IL-6. We hypothesize that the downregulation of α4β7 on naïve T cells functions 1) to allow space for virus-specific effector T cells to expand in the GALT and 2) to exclude bystander-activated T cells from the GALT in order to prevent mistrafficking, which could cause autoimmune diseases.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19
Thu, 4 Jul 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/15864/ https://edoc.ub.uni-muenchen.de/15864/1/Stephan_Nicolas.pdf Stephan, Nicolas ddc:610, ddc:600, Medizinische Fakultät
Referat von Fritz Peyer, Rektor IGW International, an der IGW Konferenz 2009 zum Thema missionale Theologie: gesellschaftsrelevante Theologie.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 01/19
Epithelzellen spielen im Immunsystem eine wichtige Rolle als Vermittler zwischen äußerem Milieu und darunterliegender Mukosa. Epithelzellen treten als Erste mit potentiellen Pathogenen in Kontakt: durch die Sekretion von Zytokinen als Warnsignale an umliegende Zellen können sie eine Entzündungsreaktion einleiten. Yersinia enterocolitica ist ein enteropathogener, vorwiegend extrazellulär lokalisierter Erreger, der eine akute Enterokolitis, Sepsis und immunologische Folgeerkrankungen verursacht. Die Rolle der intestinalen Epithelzellen bei der Infektion mit Y. enterocolitica ist bisher nicht ausreichend erörtert. Ziel dieser Arbeit war zum einen die Untersuchung des von Epithelzellen initiierten Zytokin-Netzwerks während der frühen Phase der Y. enterocolitica- Infektion. Hierzu wurden HeLa-Zell-Monolayer mit verschiedenen Y. enterocolitica- Stämmen infiziert und mittels Reverser Transkriptions (RT)-PCR zunächst wichtige Zytokine identifiziert. Die Kinetik der Zytokin-Produktion wurde durch semiquantitative RT-PCR analysiert sowie die intra- oder extrazelluläre Lokalisation der Zytokine mittels ELISA quantitativ erfasst. Die Stimulation von epithelialen Zellen mit rekombinanten humanen Zytokinen lieferte weitere Informationen über die Funktion der einzelnen Zytokine. Zum anderen wurden die Mechanismen der Wirt-Pathogen- Interaktion analysiert, die das Zytokin-Netzwerk während der initialen Phase der Y. enterocolitica-Infektion auslösen. Die Auswirkungen der Hemmung der bakteriellen Invasion (durch PI3-Kinase-Inhibitoren) sowie der bakteriellen Proteinsynthese (mittels Antibiotika) wurden untersucht. Durch die Infektion von Epithelzellen mit verschiedenen bakteriellen Mutantenstämmen gelang es, die Bedeutung des chromosomal kodierten Oberflächenproteins Yersinia Invasin zu charakterisieren. Folgende Ergebnisse wurden im Rahmen dieser Arbeit erzielt: 1. Y. enterocolitica pYV– induziert eine Stunde nach Infektion von HeLa-Zellen die de novo-Synthese von IL-8-, IL-1a-, MCP-1-, IL-1b-, GM-CSF- und TNF-a- mRNA. Y. enterocolitica pVY+ hemmt durch bestimmte Yersinia outer proteins die de novo-Synthese aller untersuchten Zytokine in HeLa-Zellen. 2. Die Zytokin-mRNA-Produktion in HeLa-Zellen nach Y. enterocolitica pYV–-Infektion erreicht nach 3 h ihr Maximum, um 5–6 h nach Infektion wieder auf Normalwerte abzufallen. IL-8 wird hierbei als Erstes und in den größten Mengen produziert. Diese pro-inflammatorische Zytokin-Antwort ist wahrscheinlich verantwortlich für den histopathologisch beobachteten massiven Einstrom von Immunzellen in infizierte Peyer’sche Plaques, was deren Zerstörung zur Folge hat. 3. Nur IL-8, MCP-1 und GM-CSF werden von HeLa-Zellen sekretiert, IL-1a und IL-1b verbleiben intrazellulär. IL-1a stimuliert bei HeLa-Zellen eine proinflammatorische Zytokin-Antwort, nicht jedoch IL-8, MCP-1 oder GM-CSF. Dies spricht für eine spezielle Rolle von IL-1: es könnte als ‚Verstärker-Zytokin’ dienen, das erst im späteren Verlauf der Infektion, nach Lyse der infizierten Zellen, freigesetzt wird und eine erneute Zytokin-Produktion verursacht. 4. Die Zytokin-Induktion nach Y. enterocolitica-Infektion von HeLa-Zellen ist wahrscheinlich nicht LPS-vermittelt. 5. Auch nach Hemmung der bakteriellen Invasion durch Wortmannin, einem PI3- Kinase-Inhibitor, beobachtet man die gleichen Zytokin-Antwort: schon die Adhäsion der Bakterien an die Wirtszelle genügt, um eine inflammatorische Zytokin- Reaktion auszulösen. 6. Wir zeigten, dass die Zytokin-Induktion durch die Bindung von Yersinia Invasin an b1-Integrine der Wirtszelle vermittelt wird: Eine Invasin-defiziente Y. enterocolitica- Mutante löst (ebenso wie ein nicht-invasiver E. coli-Stamm) keine Zytokin- Reaktion in HeLa-Zellen aus. Der Transfer des Invasin-Gens in E. coli hingegen vermittelt diesem die Fähigkeit, eine inflammatorische Zytokin-Antwort auszulösen. 7. Die Invasin-induzierte Zytokin-Antwort nach Y. enterocolitica pYV– ist unabhängig von bakterieller Proteinbiosynthese oder einem intakten Typ III-Sekretionssystem: auch Gentamicin- oder Hitze-getötete Yersinien induzieren eine inflammatorische Zytokin-Antwort wie metabolisch aktive Yersinien. Diese Ergebnisse verdeutlichen zum einen die wichtige Rolle von Epithelzellen bei der Generierung von Signalen zur Initiation der Abwehrreaktion des Immunsystems gegen Y. enterocolitica. Zum anderen wurde Yersinia Invasin als Pathogenitätsfaktor charakterisiert, der gezielt eine zelluläre Entzündungsreaktion der Darmmukosa auf eine Y. enterocolitica-Infektion initiiert.
The distribution of the functional subsets of porcine T cells, the cytolytic/suppressor (Tc/s) and the helper/inducer (Th/i) cells was studied in cryostat sections of thymus, lymph nodes, tonsils, Peyer's patches, spleen and liver using the indirect immunoperoxidase technique. Three murine monoclonal antibodies (mAb) were used. The mAb 8/1 reacts with an antigen present on all T cells and on cells of the myeloid lineage; the antigen has not yet been characterized biochemically. The mAb 295/33 (anti-T8) binds to the porcine T8 antigen and defines the Tc/s subset, while mAb PT-4 (anti-T4) detects the porcine T4 antigen and defines the Th/i subset. Practically all thymocytes were stained by mAb 8/1. The majority of cortical thymocytes apparently co-expressed T8 and T4, whereas distinct fractions of medullary cells were labelled by either anti-T8 or anti-T4. In peripheral lymphoid organs all three mAb reacted with cells in the thymus-dependent areas and with cells scattered in the lymphoid follicles. In lymph nodes, tonsils and Peyer's patches, anti-T8 and anti-T4 each labelled approximately half of the cells stained by mAb 8/1. In the periarteriolar lymphoid sheath of the spleen, anti-T4 labelled more cells than did anti-T8. The reactivity of mAb 8/1 with the Kupffer cells of the liver demonstrated the expression of the 8/1 antigen on cells of the monocyte lineage. The T8 and T4 antigens could not be detected in acetone-fixed and paraffin-embedded sections, while the antigen recognized by mAb 8/1 remained preserved. Altogether, despite an inverted microanatomical structure of porcine lymph nodes, the frequency and distribution of T8+ and T4+ cells in thymus-dependent areas proved to be similar to those found in other species.
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