Podcasts about dha omega

Did you know that 90% of the world is deficient in EPA & DHA, two critical omega-3 fats? In this episode, we sit down with Elana Natker, a Registered Dietitian and spokesperson with more than two decades of communications experience, to dive deep into the science of omega-3s and why they matter. Tune in for a practical, science-backed conversation that will change the way you think about fats in your diet.We cover: What makes omega-3s unique and how they differ from other fats The best sources of EPA & DHA (not all fish are created equal!) The SMASH acronym for choosing the right fish How much EPA & DHA you really need  The impact on aging, mental health, recovery, and even post-concussion support Omega-6 fats and what to know about seed oils The Omega-3 Index: how to measure your levels Myth-busting common misconceptions about omega-3sLinks: Best Fish Sources of Omega-3s How to read an omega-3 supplement label Some trusted DHA/EPA supplement brands Global Organization for EPA & DHA Omega-3s 27:30 Elana's perspective on the 2024 cohort study of fish oil supplementation in the BMJ Reach out to Dina or Bob to order your OmegaQuant Omega3 Index testing Dr. Michael Lewis concussion protocol International Society of Sports Nutrition Position Stand on Omega-3sMore about our guest:Elana Natker, MS, RD, Director, Consumer and Health Practitioner Communications for GOEDElana is a U.S. and U.K.-based, nationally recognized food and nutrition expert and spokesperson with more than two decades of communications experience. Her first job was as an on-camera spokesperson, which then led to a thriving career in public relations, working for major agencies in Chicago, Denver and Washington, D.C. Her client work in the areas of food, health and wellness piqued her interest in nutrition, so Elana went back to school to earn a master's degree and undergo the training and testing required to become a registered dietitian. Her work with GOED, the Global Organization for EPA and DHA Omega-3s, began in 2015, where she manages the organization's consumer and health professional education and outreach. She is adept at translating complicated science in a way that both consumers and health influencers would understand. Her primary skills are in nutrition strategy, science-backed messaging, content development and health professional education. An accomplished speaker, Elana has also presented at industry events and for health professionals, including dietitians and nurse practitioners.Elana is active in the Academy of Nutrition and Dietetics, having served as chairperson of Nutrition Entrepreneurs (NE) in 2018-19, among other leadership roles. She has also received several awards, including 2023 Outstanding Leader by the Dietitians in Business and Communications, and the 2017 Emerging Leader in Dietetics by the D.C. Metro Academy of Nutrition and Dietetics. -------Help keep our podcast free from sponsors and take advantage of special benefits and opportunities for bonus content with Bob and Dina. Go to our new Patreon to show your support and join our Community: https://www.patreon.com/isnpodcast Connect with us on Instagram @isnpodcast and on Facebook @insidesportsnutrition To learn more about Bob's services, go to www.enrgperformance.com and to see Dina's services, head over to www.nutritionmechanic.com.

Episode 160. Let's dive into the powerful connection between nutrition and mental health, exploring how a diet rich in brain-boosting superfoods can improve mental wellness and even reduce anxiety and depression. We'll discuss the Mediterranean diet, key nutrients like omega-3s and magnesium, and practical tips for incorporating these foods into your daily routine for optimal brain health. As promised, here are the products I mentioned in this episode: Organic Whole Milk with DHA Omega-3: https://amzn.to/4gfmaIw Garden of Life Organic Flax and Chia Seeds: https://amzn.to/4hzbLJ7 Chopped Walnuts from Whole Foods: https://amzn.to/3CrP0rw Organic Raw Almonds: https://amzn.to/3WAojb7 Organic Raw Cashews: https://amzn.to/4hcwZws Organic Pumpkin Seeds: https://amzn.to/4haoimm Organic Spinach from Whole Foods: https://amzn.to/4hbZ9aR Organic Avocados from Whole Foods: https://amzn.to/4ggh8Mf My Favorite Dark Chocolate: https://amzn.to/3PT5P1u Organic Whole Milk Probiotic Yogurt: https://amzn.to/3Cq33Ob Organic Rolled Oats: https://amzn.to/40QwHWt Organic Blueberries: https://amzn.to/4aAyYYV Visit First Line's website and blog: ⁠https://www.firstlinepodcast.com Thank you to befree for partnering with First Line. Visit befreeco.com for more info. Content on First Line is for educational and informational purposes only, not as medical advice. Views expressed are my own and do not represent any organizations I am associated with.

In this session with Virtus, Western Sales Manager, Renee Smith shares the impact that feeding adequate levels of essential fatty acids have on embryo development and retention. Listen in to learn how feeding EPA/DHA for greater reproductive efficiency is working in breeding heifers, in IVF programs, and in lactating herds as well. This episode is sponsored by Virtus Nutrition. At Virtus Nutrition our mission is to help you feed a better balance of fatty acids to improve reproduction, health, and profitability. In the early 2000's, we invented the process to deliver EPA/DHA in a form that dairy cows can utilize. Since then, we've developed several products, including Strata and EnerG-3, that give customers flexibility in how to deliver these essential fatty acids to their cows. Lost pregnancies are costly at every stage of pregnancy, and EPA/DHA is the pregnancy nutrient that resolves inflammation, supports healthy embryo development, and improves retention of pregnancy.

In this episode, we're delving into the fascinating world of sirtuins, exploring their role in countering the 9 hallmarks of cellular aging, and uncovering ways to optimize their activity for our benefit. We'll be exploring 7 proven strategies, backed by scientific research, that can effectively boost the expression of these longevity-promoting sirtuins within the body. Topics: 1. Introduction - Overview of NAD+ and its role in energy metabolism - Previous discussion on strategies to increase NAD+ levels - Importance of NAD+ in other reactions such as those mediated by sirtuins 2. Sirtuins: Introduction and Background - Definition and origin of the term "sirtuins" - Discovery of sirtuins and their role in yeast aging - Transition from yeast cells to mammalian cells - Introduction to SIRT1 as a focus for exploration 3. SIRT1: NAD+-Dependent Histone Deacetylase - Role of SIRT1 as an NAD+-dependent histone deacetylase - Gene silencing / gene expression - SIRT1's influence on "genome stability" mediated by its ability to silence genes 4. SIRT1's Multi-Faceted Activities - Beyond histone deacetylation: SIRT1's reach to non-histone proteins - Deacetylation of p53 and suppression of cellular senescence - Enhancement of telomere integrity - Connecting these activities back to those 9 hallmarks of aging 5. The Sirtuin Enhancement Toolkit for Longevity: 7 Strategies - Resveratrol and Pterostilbene - Increasing NAD+ availability through various methods - Exercise's influence on SIRT1 expression - DHA (Omega-3 fatty acid) and its role in activating SIRT1 - Zinc's importance for SIRT1's structural integrity and function - Nutraceuticals: Berberine, quercetin, fisetin, and curcumin - Intermittent fasting and its impact on NAD+ levels and SIRT1 Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit ⁠synthesisofwellness.com⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠linktr.ee/synthesisofwellness⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Feeling stressed and unfocused lately? You might be deficient in DHA,an essential Omega-3. DHA makes up half the fat in your brain and eyes - and without it, entirehealth systems crumble. Thankfully, there's an easy solution. Orlo Nutrition provides active omega-3s in the polar lipid form, for up to 3 x better absorption than fish oil. You'll get all the benefits of the omega-3s EPA and DHA in a smaller pill - without that fishy burp. These active omegas get straight to work supporting your healthy focus, attention, vision, and so much more.Learn more 

You may remember the breakthrough study Dr. Martin shared a few months ago about how DHA omega-3 was able to shrink tumours. A real life case history has now been published where a man's cancer was put into remission. Dr. Martin shares the case history of a man with 4th stage lung cancer who fought his advanced prognosis with high doses of DHA omega-3. The patient was followed closely by his oncologist and with only taking high doses of DHA, the man was able to shrink the tumors and put his cancer into remission. Join Dr. Martin to learn why DHA omega-3 is so important and what he would do if ever diagnosed with cancer. Don't miss this very informative episode!  

Huberman Lab Podcast Notes Key Takeaways Intermittent challenges or stressors to your system are good – humans are evolved for challenges, but today's lifestyle has taken away most of the common struggles we experienced beforeThree key nutrients for the brain and body: (1) sulforaphane; (2) omega-3; (3) vitamin DFood sources of sulforaphane: broccoli (barely cooked), broccoli sprouts, moringa powder“I personally think [omega-3 fish oil] is one of the most powerful anti-inflammatory things, dietary lifestyle things we can get easily that is going to powerfully modulate the way you think, the way you feel, and the way you age.” – Dr. Rhonda PatrickVitamin D is not just a vitamin! 70% of the US population is deficient – it's worth measuring & supplementing to optimal bone health, immunity, hormone conversion, and moreThere's a strong dose-dependent nature of sauna use: people who use sauna 4-7x/week have a lower risk (60% reduction) of dementia and Alzheimer's; people who use sauna 2-3x/week have a 20% reduction in riskHeat stress mimics moderate cardiovascular exercise effect – this could be a great onramp for people who are otherwise unable to exercise due to disability or whatever reasonThe cardiorespiratory system is improved in people who do both sauna and exercise compared to doing either aloneStress & memory: if you're too relaxed you won't remember things as well; at peak levels of stress, you remember things better until you reach too high a level of panic               Read the full notes @ podcastnotes.orgMy guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children's Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure  (00:03:12) Momentous Supplements (00:04:27) The Brain-Body Contract  (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed  (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)  (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges  (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2  (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation  (00:48:40) EPA Omega-3s & Depression  (00:52:02) Krill Oil vs. Fish Oil Supplements?  (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy  (00:59:24) Tool 4: Food Sources of EPA Omega-3s  (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s  (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure  (01:22:18) Role of Vitamin D, Gene Regulation  (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation  (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D  (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate  (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning', PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle  (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna  (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood  (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer's and Dementia Risk  (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)  (02:31:29) Insulin signaling, FOXO3 & Longevity  (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility  (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin  (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab Podcast Notes Key Takeaways Intermittent challenges or stressors to your system are good – humans are evolved for challenges, but today's lifestyle has taken away most of the common struggles we experienced beforeThree key nutrients for the brain and body: (1) sulforaphane; (2) omega-3; (3) vitamin DFood sources of sulforaphane: broccoli (barely cooked), broccoli sprouts, moringa powder“I personally think [omega-3 fish oil] is one of the most powerful anti-inflammatory things, dietary lifestyle things we can get easily that is going to powerfully modulate the way you think, the way you feel, and the way you age.” – Dr. Rhonda PatrickVitamin D is not just a vitamin! 70% of the US population is deficient – it's worth measuring & supplementing to optimal bone health, immunity, hormone conversion, and moreThere's a strong dose-dependent nature of sauna use: people who use sauna 4-7x/week have a lower risk (60% reduction) of dementia and Alzheimer's; people who use sauna 2-3x/week have a 20% reduction in riskHeat stress mimics moderate cardiovascular exercise effect – this could be a great onramp for people who are otherwise unable to exercise due to disability or whatever reasonThe cardiorespiratory system is improved in people who do both sauna and exercise compared to doing either aloneStress & memory: if you're too relaxed you won't remember things as well; at peak levels of stress, you remember things better until you reach too high a level of panic               Read the full notes @ podcastnotes.orgMy guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children's Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure  (00:03:12) Momentous Supplements (00:04:27) The Brain-Body Contract  (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed  (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)  (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges  (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2  (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation  (00:48:40) EPA Omega-3s & Depression  (00:52:02) Krill Oil vs. Fish Oil Supplements?  (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy  (00:59:24) Tool 4: Food Sources of EPA Omega-3s  (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s  (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure  (01:22:18) Role of Vitamin D, Gene Regulation  (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation  (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D  (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate  (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning', PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle  (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna  (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood  (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer's and Dementia Risk  (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)  (02:31:29) Insulin signaling, FOXO3 & Longevity  (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility  (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin  (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

My guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children's Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure  (00:03:12) Momentous Supplements (00:04:27) The Brain-Body Contract  (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed  (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)  (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges  (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2  (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation  (00:48:40) EPA Omega-3s & Depression  (00:52:02) Krill Oil vs. Fish Oil Supplements?  (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy  (00:59:24) Tool 4: Food Sources of EPA Omega-3s  (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s  (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure  (01:22:18) Role of Vitamin D, Gene Regulation  (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation  (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D  (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate  (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning', PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle  (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna  (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood  (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer's and Dementia Risk  (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)  (02:31:29) Insulin signaling, FOXO3 & Longevity  (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility  (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin  (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

A new study shows that diets high in processed foods are linked to brain inflammation that results in dementia. Listen in this week as Dee discusses the role of the omega-3 fatty acid DHA in fending off the inflammatory response in the brain that leads to dementia, and how you can get more DHA in your diet.Link to Pro-DHA Fish Oil: https://amzn.to/3NHAooL

What types of workouts are pregnancy friendly and what aren't? In this episode, vegan sports dietitian, Tara shares strategies to safely stay active during your vegan pregnancy. Tara includes real, nutritious vegan pre-workout meal ideas to fuel your prenatal workout without supplements. In this episode, you'll discover answers to these questions: What kinds of exercises are safe during pregnancy? What to consider when choosing a vegan protein powder while pregnant? What is the difference between ALA vs DHA Omega 3s?  And more! Remember: always follow the advice of your doctor or midwife when it comes to prenatal exercise. This is for informational purposes only and is not meant to be prescriptive. Connect with Tara:Instagram: @vegan.sports.nutrition Connect with Maya:Website: Vegan Pregnancy Collective Instagram: @vegan.prenatal.nutrition

When stressed, people are quicker to jump to the worst conclusion University College London, July 29, 2021 When under stress, people reach undesirable conclusions based on weaker evidence than when they are relaxed, finds a new study led by UCL researchers. The findings, published today in the Journal of Neuroscience, show that stress can make people more likely to conclude the worst scenario is true. Senior author Professor Tali Sharot (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said: "Many of the most significant choices you will make, from financial decisions to medical and professional ones, will happen while you feel stressed. Often these decisions require you to first gather information and weigh the evidence. For example, you may consult multiple physicians before deciding on a best course of medical treatment. We wanted to find out: does feeling stressed change how you process and use the information you gather? "Our research suggests that under stress, people weight each piece of evidence that supports undesirable conclusions more than when they are relaxed. In contrast, how they weigh evidence that supports desirable conclusions is not affected by stress. As a result, people are more likely to conclude the worst is true when they are stressed." For the study, 91 volunteers played a categorisation game, in which they could gather as much evidence as they wanted to decide whether they were in a desirable environment (which was associated with rewards) or an undesirable environment (which was associated with losses). They were incentivised for accuracy. Prior to playing the game, 40 of the volunteers were told that they had to give a surprise public speech, which would be judged by a panel of experts. This caused them to feel stressed and anxious. The researchers found that under stress, the volunteers needed weaker evidence to reach the conclusion that they were in the undesirable environment. By contrast, stress did not change the strength of the evidence needed to reach the conclusion that they were in the desirable environment. Lead author, PhD student Laura Globig (UCL Psychology & Language Sciences and Max Planck UCL Centre for Computational Psychiatry and Ageing Research) said that "we usually think of stressful situations as a hindrance to our decision-making process. But the pattern of learning we have uncovered may counterintuitively be adaptive, because negative beliefs may drive people to be extra cautious when in threatening environments."   Thai Cabinet Approves Use of Fah Talai Jone (green chiretta) to Treat Asymptomatic COVID-19 Cases Bangkok Post, July 22, 2021 Prime Minister Prayut Chan-o-cha has instructed authorities to set up a committee to study the use of green chiretta (Andrographis paniculata) extracts to treat Covid-19 patients with mild symptoms. The announcement was made at a cabinet meeting on Tuesday, which was convened to discuss additional measures to help curb the Covid-19 outbreak, the premier said on Wednesday. Deputy Prime Minister and Public Health Minister Anutin Charnvirakul was appointed head of the committee. It will coordinate studies on the safety and efficacy of green chiretta extracts on Covid-19 patients, as well as draft a strategic plan to promote Thai traditional medicine in general. The decision was taken in response to a proposal from Justice Minister Somsak Thepsutin, who urged the government to scale up the use of traditional medicines on Covid-19 patients with mild symptoms. This comes amid a vaccine shortage which has led to criticism for the government. His proposal came with evidence showing the Department of Corrections' success in treating 12,376 inmates who were infected with Covid-19 with green chiretta extracts. Of this number, 5,045 inmates were in Chiang Mai Central Prison, 2,100 in Nonthaburi Provincial Prison and 5,231 in Bang Kwang Central Prison also in Nonthaburi, said Mr Somsak. Before prescribing the herbal medicine to infected inmates, Mr Somsak said he had studied information by the Department of Thai Traditional and Alternative Medicine, which recommended a dosage of 180mg of andrographolides from green chiretta for five consecutive days to patients with mild symptoms. Citing the same research, the minister said each rai of land can yield up to 600kg of green chirettas, which can be turned into roughly 375,000 herbal extract capsules, he said. A total of 3.1 billion such capsules will be needed to cover all Thais, which means 8,400 rai of land will need to be planted with the herb, he said. The Department of Corrections now plans to produce about 50 million capsules of the herbal medicine in the next four months, which it aims to prescribe to about 50% of the prison population, he said. Due to its medical benefits, green chiretta has become a cash crop which is now in high demand in the export sector, he said. Mr Somsak added that the medicinal herb costs about 450 baht per kg    Taking breaks while learning improves memory   Max Planck Institute of Neurobiology (Germany), July 29, 2021 We remember things longer if we take breaks during learning, referred to as the spacing effect. Scientists at the Max Planck Institute of Neurobiology gained deeper insight into the neuronal basis for this phenomenon in mice. With longer intervals between learning repetitions, mice reuse more of the same neurons as before—instead of activating different ones. Possibly, this allows the neuronal connections to strengthen with each learning event, such that knowledge is stored for a longer time. Many of us have experienced the following: the day before an exam, we try to cram a huge amount of information into our brain. But just as quickly as we acquired it, the knowledge we have painstakingly gained is gone again. The good news is that we can counteract this forgetting. With expanded time intervals between individual learning events, we retain the knowledge for a longer time. But what happens in the brain during the spacing effect, and why is taking breaks so beneficial for our memory? It is generally thought that during learning, neurons are activated and form new connections. In this way, the learned knowledge is stored and can be retrieved by reactivating the same set of neurons. However, we still know very little about how pauses positively influence this process—even though the spacing effect was described more than a century ago and occurs in almost all animals. Learning in a maze Annet Glas and Pieter Goltstein, neurobiologists in the team of Mark Hübener and Tobias Bonhoeffer, investigated this phenomenon in mice. To do this, the animals had to remember the position of a hidden chocolate piece in a maze. On three consecutive opportunities, they were allowed to explore the maze and find their reward—including pauses of varying lengths. "Mice that were trained with the longer intervals between learning phases were not able to remember the position of the chocolate as quickly," explains Annet Glas. "But on the next day, the longer the pauses, the better was the mice's memory." During the maze test, the researchers additionally measured the activity of neurons in the prefrontal cortex. This brain region is of particular interest for learning processes, as it is known for its role in complex thinking tasks. Accordingly, the scientists showed that inactivation of the prefrontal cortex impaired the mice's performance in the maze. "If three learning phases follow each other very quickly, we intuitively expected the same neurons to be activated," Pieter Goltstein says. "After all, it is the same experiment with the same information. However, after a long break, it would be conceivable that the brain interprets the following learning phase as a new event and processes it with different neurons." However, the researchers found exactly the opposite when they compared the neuronal activity during different learning phases. After short pauses, the activation pattern in the brain fluctuated more than compared to long pauses: In fast successive learning phases, the mice activated mostly different neurons. When taking longer breaks, the same neurons active during the first learning phase were used again later. Memory benefits from longer breaks Reactivating the same neurons could allow the brain to strengthen the connections between these cells in each learning phase—there is no need to start from scratch and establish the contacts first. "That's why we believe that memory benefits from longer breaks," says Pieter Goltstein. Thus, after more than a century, the study provides the first insights into the neuronal processes that explain the positive effect of learning breaks. With spaced learning, we may reach our goal more slowly, but we benefit from our knowledge for much longer. Hopefully, we won't have forgotten this by the time we take our next exam!     The flavonoid epicatechin inhibits progressive tau pathology in Alzheimer's University of Bath (UK), July 23, 2021 According to news reporting originating in Avon, United Kingdom, by NewsRx journalists, research stated, “Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer's Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor bioavailability and low potency, challenging their therapeutic translation.”  Green tea, cocoa, blackberries and blueberries are high in epicatechin. The news reporters obtained a quote from the research from the University of Bath, “We previously reported that oral administration of the flavonoid (-)-epicatechin (EC) reduced Amyloid-beta (A beta) plaque pathology in APP/PS1 transgenic mice. Here, we investigated whether EC impacts on tau pathology, independent of actions on A beta, using rTg4510 mice expressing P301L mutant tau. 4 and 6.5 months old rTg4510 mice received EC (similar to 18 mg/day) or vehicle (ethanol) via drinking water for 21 days and the levels of total and phosphorylated tau were assessed. At 4 months, tau appeared as two bands of similar to 55 kDa, phosphorylated at Ser262 and Ser396 and was unaffected by exposure to EC. At 6.5 months an additional higher molecular weight form of tau was detected at similar to 64 kDa which was phosphorylated at Ser262, Ser396 and additionally at the AT8 sites, indicative of the presence of PHFs. EC consumption reduced the levels of the similar to 64 kDa tau species and inhibited phosphorylation at Ser262 and AT8 phosphoepitopes. Regulation of the key tau kinase glycogen synthase kinase 3 beta (GSK3 beta) by phosphorylation at Ser9 was not altered by exposure to EC in mice or primary neurons. Furthermore, EC did not significantly inhibit GSK3 beta activity at physiologically-relevant concentrations in a cell free assay.” According to the news reporters, the research concluded: “Therefore, a 21-day intervention with EC inhibits or reverses the development of tau pathology in rTg4510 mice independently of direct inhibition of GSK3 beta.”     Fruit compound may have potential to prevent and treat Parkinson's disease   Johns Hopkins University, July 29, 2021 Johns Hopkins Medicine researchers say they have added to evidence that the compound farnesol, found naturally in herbs, and berries and other fruits, prevents and reverses brain damage linked to Parkinson's disease in mouse studies. he compound, used in flavorings and perfume-making, can prevent the loss of neurons that produce dopamine in the brains of mice by deactivating PARIS, a key proteininvolved in the disease's progression. Loss of such neurons affects movement and cognition, leading to hallmark symptoms of Parkinson's disease such as tremors, muscle rigidity, confusion and dementia. Farnesol's ability to block PARIS, say the researchers, could guide development of new Parkinson's disease interventions that specifically target this protein. "Our experiments showed that farnesol both significantly prevented the loss of dopamine neurons and reversed behavioral deficits in mice, indicating its promise as a potential drug treatment to prevent Parkinson's disease," says Ted Dawson, M.D., Ph.D., director of the Johns Hopkins Institute for Cell Engineering and professor of neurology at the Johns Hopkins University School of Medicine. Results of the new study, published July 28, in Science Translational Medicine, detail how the researchers identified farnesol's potential by screening a large library of drugs to find those that inhibited PARIS. In the brains of people with Parkinson's disease, a buildup of PARIS slows down the manufacture of the protective protein PGC-1alpha. The protein shields brain cells from damaging reactive oxygen molecules that accumulate in the brain. Without PGC-1alpha, dopamine neurons die off, leading to the cognitive and physical changes associated with Parkinson's disease. To study whether farnesol could protect brains from the effects of PARIS accumulation, the researchers fed mice either a farnesol-supplemented diet or a regular mouse diet for one week. Then, the researchers administered pre-formed fibrils of the protein alpha-synuclein, which is associated with the effects of Parkinson's disease in the brain. The researchers found that the mice fed the farnesol diet performed better on a strength and coordination test designed to detect advancement of Parkinson's disease symptoms. On average, the mice performed 100% better than mice injected with alpha-synuclein, but fed a regular diet. When the researchers later studied brain tissue of mice in the two groups, they found that the mice fed a farnesol-supplemented diet had twice as many healthy dopamine neurons than mice not fed the farnesol-enriched diet. The farnesol-fed mice also had approximately 55% more of the protective protein PGC-1alpha in their brains than the untreated mice. In chemical experiments, the researchers confirmed that farnesol binds to PARIS, changing the protein's shape so that it can no longer interfere with PGC-1alpha production. While farnesol is naturally produced, synthetic versions are used in commerce, and the amounts people get through diet is unclear. The researchers caution that safe doses of farnesol for humans have not yet been determined, and that only carefully controlled clinical trials can do so. Though more research is needed, Dawson and his team hope farnesol can someday be used to create treatments that prevent or reverse brain damage caused by Parkinson's disease.   Plant compounds reveal anticancer mechanisms Russian Academy of Sciences, July 28 2021.  Research published on June 9, 2021 in Scientific Reportsexplored mechanisms involved in the cancer protective effects of 30 compounds derived from fruits and vegetables. The researchers hope that their findings will contribute to the formulation of new drugs that will have fewer side effects than drugs currently in use.   “To create potent new drugs that will target only the tumor, it was necessary to determine how dietary compounds affect cell proteins in the prevention and treatment of cancer,” explained coauthor Grigory Zyryanov, who is a professor at the Russian Academy of Sciences. “Therefore, by modeling molecular mechanisms, we figured out how substances bind to proteins. This allowed us to determine the pool of therapeutic targets that the drugs will subsequently target. For example, these are anti-apoptotic (prevent apoptosis) and pro-apoptotic (induce apoptosis) proteins, protein kinases, and others. But a key drug target is phosphatidylinositol-3-kinase . . . This enzyme influences mutations in cancer, rearrangement, and amplification of genes.” Compounds investigated in the study included emodin, eugenol, gingerol, sulforaphane, linalool, catechin, oleanolic acid, ursolic acid, curcumin, yakuchinone-A, pinusolide, alpha-boswellic acid, oleandrin, sesquiterpene lactone-326, resveratrol, triterpenoid, beta-boswellic acid, anethole, capsaicin, glycolic acid, quercetin, genistein, ellagic acid, flavopiridol, zerumbone, garcinol, guggulsterone, parthenolide, halogenated monoterpenes and silibinin. Of these compounds, silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone and oleanolic acid had the greatest binding affinity with phosphatidylinositol-3-kinase alpha (P13K), which is involved in functions that can contribute to cancer. Other targets identified as binding with various compounds included PKC-η, Ras and H-Ras.  “We assumed that the foods we selected for the study had anti-cancer properties, but this needed to be verified,” Dr Zyryanov noted. “As a result, we found out that diseased cells stop development under the influence of certain combinations of food compounds.”     Meta-analysis supports potential of omega-3s for ADHD Kings College London, July 31, 2021 Omega-3s fatty acid supplements may improve symptoms and cognitive performance in children and adolescents with attention deficit hyperactivity disorder (ADHD), according to a meta-analysis of gold standard clinical trials. Data from seven clinical trials involving over 500 children and adolescents indicated that omega-3s were associated with improvements in clinical symptoms of ADHD, while data from three clinical trials involving over 200 children and adolescents indicated a positive impact on cognitive measures associated with attention. “[W]e provide strong evidence supporting a role for n3-PUFAs deficiency in ADHD, and for advocating n-3 PUFAs supplementation as a clinically relevant intervention in this group, especially if guided by a biomarker-based personalization approach,” wrote the authors, led by Jane Pei-Chen Chang from King's College London, in Neuropsychopharmacology . Boosting EPA/DHA intakes Commenting independently on the meta-analysis, Harry Rice, PhD, VP of regulatory & scientific affairs for the Global Organization for EPA and DHA Omega-3s (GOED): “In the past, I've been lukewarm on whether or not increasing EPA/DHA intake benefits children with ADHD. Results from this meta-analysis put me a little closer to believing. “Minimally, given the low side effect profile of omega-3s versus the drugs of choice to treat ADHD, I would highly recommend first increasing intake of EPA/DHA. This is particularly true if a child doesn't eat at least two servings of fatty fish a week or doesn't take an omega-3 supplement on a regular basis.” Meta-analysis details The new meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and used established scientific literature databases to identify appropriate studies for inclusion. Data from seven randomized controlled trials (RCTs) with 534 young people indicated that that omega-s3 supplementation significantly improved inattention and hyperactivity symptoms, according to parental reports. Additional analysis revealed that the improvements in hyperactivity were only observed when doses of EPA (eicosapentaenoic acid) of 500 mg/day or more were used. Interesting, the researchers did not find improvements in hyperactivity and inattention when they looked at teacher's reports, unlike what was reported by parents. Omega-3 supplements were associated with improvements in select measures of cognitive performance, said the researchers. “N-3 PUFAs are crucial for optimal neurotransmitter function: for example, incorporating more EPA and DHA in the cell membrane can increase cholesterol efflux, modulate lipid raft clustering and disruption, and affect the function of the dopamine transporter (DAT), which in turn may affect attention and executive function by regulating synaptic dopamine levels,” wrote the researchers. Omega-3 levels Data from case-control studies were also collected to assess if omega-3 levels were also associated with ADHD, with results indicating that children and adolescents with ADHD had lower levels of EPA, DHA (docosahexaenoic acid),and total omega-3s. “In the context of ‘personalised medicine', it is tempting to speculate that a subpopulation of youth with ADHD and with low levels of n-3 PUFAs may respond better to n-3 PUFAs supplementation, but there are no studies to date attempting this stratification approach,” wrote the researchers. “However, we have [previously] shown that individuals at genetic risk of developing depression in the context of the immune challenge, interferon-alpha (IFN-alpha), have lower levels of RBCs n3-PUFAs, and that n-3 PUFAs supplementation prevents the onset of IFN-alpha-induced depression, arguably by replenishing the endogenously low anti-inflammatory PUFAs in the ‘at risk' individuals.”

Drive with Dr. Peter Attia Podcast Notes Key Takeaways The brain is an electrical system that uses lipids to facilitate firing but uses glucose for energyThe brain prefers glucose as the predominant source of energy via GLUT1; the rest of the body uses GLUT4 (insulin-regulated transporter)The brain does its best to regulate glucose content, not dependent on insulin signalingWhen glucose is not available, the brain extracts all ketone bodies from fatty acids outside the brain to maintain itself  Historically, ApoE4 was associated with better outcomes prenatally and against parasite and disease – that changed as more movement, interbreeding, and dietary challenges took place“If you have two copies of ApoE4, your chance of getting Alzheimer’s disease increases 12-fold. If you have one copy of ApoE4 your chance of getting Alzheimer’s increase 2-4 fold” – Dr. Hussein YassineUnlike ApoA or ApoB you can’t make an assumption about the function of ApoE based on its concentrationAncestral diets rich with meat supported richness of ApoE4 – moving to a plant-based diet, increase in carbs supported ApoE 2 and ApoE 3 because they support GLUT1 expressionWe rely on diet to get omega-3s: the human body doesn’t have an efficient system to make EPA and DHA“Omega-3 fatty acids are important for the brain, we can’t make them efficiently, and we’re not consuming enough of them.” – Dr. Hussein YassineThere isn’t enough evidence to suggest supplementing with omega-3s but there is enough to suggest eating one serving of fatty fish per weekRead the full notes @ podcastnotes.org Hussein Yassine is a physician and researcher who studies brain lipid utilization in the context of finding preventative measures for cognitive impairment, specifically Alzheimer’s disease (AD). In my conversation with Hussein, we begin with a fundamental coursework in brain biology—including its architecture and energy systems. We go on to discuss what these systems look like when something goes wrong and cognitive decline ensues. We talk about the evolutionary origins of the ApoE genotype, with specific attention to the ApoE4 allele and its association with AD. We spend time discussing ApoE4 implications for the brain’s fuel utilization, notably omega-3 fatty acids: EPA and DHA. We briefly pivot to the implications of recent omega-3 trials for cardiovascular disease and return to what we currently understand about EPA/DHA and brain health; we contemplate potential dietary interventions across the lifespan to preserve and prolong cognitive function. We discuss: Hussein’s Background and introduction to brain composition (3:00); The blood-brain barrier and brain filtration (8:00); Lipids and brain function (13:00); How the brain utilizes energy (18:00); Apolipoprotein E (ApoE) structure and function in the periphery (27:30); ApoE function in the brain (38:15); Evolutionary origins of ApoE isoforms (43:45); ApoE4 variant and Alzheimer’s disease (AD) risk (53:30); Dietary fuel preference with the ApoE4 allele (1:03:00); The role of omega-3 fatty acids in the brain (1:13:30); Comparing findings from the REDUCE-IT and STRENGTH trial (1:21:45): The relationship between dietary omega-3 intake and brain health (1:34:15); Preventing cognitive decline: A critical window for DHA in ApoE4 carriers? (1:42:30); Hussein’s ongoing research and recommendations for E4 carriers (1:54:00); and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/HusseinYassine  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

You've likely heard of omega-3s by now, but are they still the “cool kids on the block” when it comes to health ingredients? We sat down with Ellen Schutt, Executive Director of GOED (the Global Organization for EPA and DHA Omega-3s) to learn about how omega-3s can help your body in ways you may not have thought of), why the industry is still hot even though it's been around for a while, and what to look for in the omega-3 space. ----- Guest: Ellen Schutt is the Executive Director of GOED, the Global Organization for EPA and DHA Omega-3s. Ellen has been with the company for nine years, and oversees all aspects of the organization's mission to increase consumption of EPA and DHA omega-3s as well as to protect the category by ensuring GOED members are manufacturing quality products that consumers can trust. Ellen previously directed GOED's communications strategy for industry and consumers and was instrumental in organizing a successful consumer education campaign in 2015. With 20 years of experience in the natural products industry, Ellen is the former editor of Nutraceuticals World magazine, an industry trade publication, and owner of Schutt Solutions, a consulting business focused on supporting growth in the dietary supplement industry. Websites: GOED Website for Industry - www.goedomega3.com GOED Website for Consumers - www.alwaysomega3s.com Fats of Life Website for Healthcare Practitioners - www.fatsoflife.com Facebook: https://www.facebook.com/AlwaysOmega3s Instagram: https://www.instagram.com/alwaysomega3s/ Twitter: https://twitter.com/alwaysomega3s LinkedIn: https://www.linkedin.com/company/goedomega-3/ ----- The NutraStrong Podcast is a production of Nutrasource, a service provider to the health products industry. Will Rowe is CEO of Nutrasource. For more information, visit www.nutrasource.ca To learn about our certification programs for health products, visit www.certifications.nutrasource.ca For more episodes, visit: www.nutrasource.ca/resources/nutrastrong-podcast/

In the first episode of The Light Diet Podcast, your host Matt Maruca, walks you through his story, how he got to where he is today, and his reasons why self optimization is necessary for our bodies. He starts by sharing that growing up he was very fortunate, but in 9th grade he hit a wall due to several ongoing health issues. When he started dealing with acne breakouts, he recalls that it was his vanity that led to the obsessive research and consumption of every bit of data he could find in order to heal his body. The information he took in about human health being tied to much more than just food and exercise fascinated him in so many ways, he thought: “wow there's something here and there has to be much more!” The real game changer was when he learned about a controversial figure, Dr. Jack Kruse. Through Dr. Kruse's blogs he learned the positive impacts of the DHA Omega-3 unsaturated fatty acid, the concept of grounding, and the effects of light exposure on the mitochondria and our body over all. If you've made it this far you're ready to learn how to optimize yourself through the 8 steps of the Light Diet. Grab your pen and paper and enjoy the show!   “Controversial figures, like Dr. Jack Kruse, are typically the people who impact the greatest change in the world.” -Matt Maruca   “You can't fix a broken car engine with premium fuel and fuel added if you can't fix broken human mitochondria with a clean diet, supplements and exercise.” -Matt Maruca   Episode Highlights: [01:41] The story that led to his journey of self optimization.  [09:15] The controversial figure! [13:24] Dr. Jack Kruse and his work. [25:16] Optimizing the mitochondria through the light diet. [50:23] How does our body resemble a car? [56:10] Food diets are not the way! [59:40] Trying to understand human diseases by understanding genetics. [01:08:57] Let's talk about the different types of diseases. [01:13:28] The importance of Dr. Jack Kruse's research.  [01:24:38] Blogs and books about research encompassing the light diet. [01:34:52] Has science helped people to be happy? [01:38:55] The negative effects of our modern lifestyle and how it bridges over. [01:42:53] Let's talk about the steps of, what Matt calls, ‘The Light Diet'. [02:09:14] The purpose of The Light Diet podcast.   Episode resources: Dr. Jack Kruse's blog Dr. Wallace Alexander Wunch The Fourth Phase of Water Health and Light The Body Electric Light shaping life Going Somewhere: Truth about a life in science   --- Connect with Matt! Instagram | Website

The Gary Null Show is here to inform you on the best news in health, healing, the environment. Pea protein-derived tripeptide shows bone-building potential University of Alberta, August 21, 2020   According to news originating from Edmonton, Canada, by NewsRx correspondents, research stated, “Osteoporosis is a bone disease affecting more than 2 million people comprising 1 in 3 women and 1 in 5 men in Canada. One possible approach to prevent this disease is to stimulate the activity of osteoblasts (bone-forming cells) using food protein-derived bioactive peptides.” Our news journalists obtained a quote from the research from the University of Alberta, “In our previous study, an ACE inhibitory tripeptide LRW (Leu-Arg-Trp) was identified from pea protein. This work aims to investigate the effect of tripeptide LRW on promoting osteoblastic activity. The tripeptide LRW treatment (50 mM) in MC3T3-E1 cells increased cell proliferation (4-fold increase) as indicated by BrdU incorporation assay. Moreover, we found that tripeptide LRW stimulated osteoblastic differentiation by increasing the levels of type 1 collagen (COL1A2; 3-fold increase), alkaline phosphatase (ALP; 4-fold increase), and runt-related transcription factor 2 (Runx2; 2-fold increase) and the activation of the protein kinase B (Akt) signaling pathway. Furthermore, tripeptide LRW increased matrix mineralization as evidenced by Alizarin-S red staining and nodule formation, osteoprotegerin levels (OPG; 2-fold increase), and wound healing based on cell migration assay.” According to the news editors, the research concluded: “Overall, pea protein-derived bioactive peptide LRW can positively modulate the activity of osteoblasts probably via the Akt/Runx2 pathway, indicating its potential use for the prevention of osteoporosis.”   Yoga linked with improved symptoms in heart patients SMS Hospital (India), August 24, 2020   Atrial fibrillation is the most common heart rhythm disorder. One in four middle-aged adults in Europe and the US will develop the condition, which causes 20-30% of all strokes and increases the risk of death by 1.5-fold in men and 2-fold in women. Reduced quality of life is common, and 10-40% of patients are hospitalised each year.2  Symptoms of atrial fibrillation include palpitations, racing or irregular pulse, shortness of breath, tiredness, chest pain and dizziness. "The symptoms of atrial fibrillation can be distressing. They come and go, causing many patients to feel anxious and limiting their ability to live a normal life," said study author Dr. Naresh Sen of HG SMS Hospital, Jaipur, India. This study investigated whether yoga could ease symptoms in patients with atrial fibrillation. The study enrolled 538 patients in 2012 to 2017. Patients served as their own controls. For 12 weeks they did no yoga, then for 16 weeks patients attended 30-minute yoga sessions every other day which included postures and breathing. During the yoga period, patients were also encouraged to practice the movements and breathing at home on a daily basis. During both study periods, symptoms and episodes of atrial fibrillation were recorded in a diary. Some patients also wore a heart monitor to verify atrial fibrillation episodes. Patients completed an anxiety and depression survey3 and a questionnaire4 assessing their ability to do daily activities and socialise, energy levels and mood. Heart rate and blood pressure were also measured. The researchers then compared outcomes between the yoga and non-yoga periods. During the 16-week yoga period, patients experienced significant improvements in all areas compared to the 12-week non-yoga period. For example, during the non-yoga period, patients experienced an average of 15 symptomatic episodes of atrial fibrillation compared to eight episodes during the yoga period. Average blood pressure was 11/6 mmHg lower after yoga training. Dr. Sen said: "Our study suggests that yoga has wide-ranging physical and mental health benefits for patients with atrial fibrillation and could be added on top of usual therapies."     Supplementing with fish oil can boost the benefits of resistance training for patients with sarcopenia New Mexico State University, August 21, 2020   A study published in the journal Sports found that taking fish oil supplements can enhance the effects of resistance training among people with sarcopenia, or age-related muscle loss. Researchers found that resistance training can help with muscle loss. But when coupled with fish oil supplementation, blood pressure also dropped, boosting the benefits of the exercise. These findings could help medical professionals develop intervention programs for adults with sarcopenia, as well as those with hypertension and other cardiovascular conditions. “Overall, our findings would provide meaningful implications for future clinical research to develop effective intervention programs for enhancing functional independence as well as cardiovascular health in older populations,” the researchers wrote. Fish oil supplements lower blood pressure levels Muscle loss leads to reduced strength. Data from the National Health and Nutrition Examination Survey for 2011–2012 estimated that about five percent of adults aged 60 and over had weak muscle strength. Meanwhile, the Centers for Disease Control and Prevention links muscle weakness to impaired mobility and mortality in older adults. Thus, it is important to prevent or slow down muscle loss. In the study, the researchers examined the effects of daily fish oil supplementation during 12 weeks of programmed resistance training on physical function and blood pressure. They sampled 28 healthy older adults with aged 66 years and above. Eighteen of the participants were female, while the rest were male. They were randomly assigned to either a group that had resistance training and fish oilsupplementation, a group that had resistance training and placebo capsules, or a group that had placebo capsules but no training. The team conducted tests at baseline and 12 weeks later, which measured hand-grip strength, physical function, timed up and go, six-minute walk and blood pressure. Results show that the two experimental groups displayed improvements in physical function while the control group performed poorer in time up and go and decreased their hand-grip strength. Meanwhile, only the group that had both resistance training and fish oil supplementation lowered their blood pressure levels, suggesting that the fish oil capsules have positive effects on blood pressure. Given these findings, the researchers concluded that resistance training and fish oil could be used as a therapeutic intervention for boosting muscular and vascular health, respectively. Harry Rice, vice president of regulatory and scientific affairs for the Global Organization for EPA and DHA Omega-3s, said that the benefits of exercise on health have been known for years. But he added, “What's really exciting about the results from the current research is that they suggest the addition of fish oil can boost those benefits.” Rice was not part of the study.     A healthy lifestyle for cardiovascular health also promotes good eye health Texas Tech University Health Sciences, August 20, 2020    In a new study, investigators found that ideal cardiovascular health, which is indicative of a healthy lifestyle, was associated with lower odds for ocular diseases especially diabetic retinopathy. These findings appearing in the American Journal of Medicine, published by Elsevier, suggest that interventions to prevent cardiovascular diseases may also hold promise in preventing ocular diseases.  Globally, about 2.2 billion people suffer from ocular diseases leading to vision impairment or blindness. Approximately half of these cases could have been prevented. The leading causes of vision impairment or blindness are age-related macular degeneration, diabetic retinopathy, cataract, and glaucoma.  "Earlier studies have observed associations between eye diseases and individual lifestyle factors such as smoking, obesity, or hypertension," explained lead investigator Duke Appiah, PhD, MPH, Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, TX, USA. "It is known that these metrics of ideal cardiovascular health do not work alone and may interact additively to result in diseases. However, prior to our research, no other studies have comprehensively evaluated the association of all of the metrics of ideal cardiovascular health with ocular diseases." Most ocular diseases show few symptoms at early stages and many people may not seek medical care despite readily available treatments. A recent online nationwide survey consisting of all racial and ethnic groups in the United States conducted by the Wilmer Eye Institute at Johns Hopkins University School of Medicine showed that 88 percent of the 2,044 respondents considered good vision to be vital to overall health with 47 percent of them rating losing their vision as the worst disease that could ever happen to them. Alarmingly, 25 percent did not have any knowledge about ocular diseases and their risk factors. This research shows that following healthy lifestyle and behavior habits can all contribute to good cardiovascular health as assessed by adherence to the American Heart Association's prescription for health metric known as Life's Simple Seven (LS7). LS7 is based on the status of seven cardiovascular disease risk factors: not smoking, regular physical activity, healthy diet, maintaining normal weight, and controlling cholesterol, blood pressure, and blood glucose levels.  Practicing these healthy lifestyles together was found to be associated with lower odds for age-related macular degeneration, diabetic retinopathy, cataract, and glaucoma. Individuals with optimal cardiovascular health had 97 percent lower odds for diabetic retinopathy compared to individuals with inadequate cardiovascular health.  Investigators evaluated data from 6,118 adults aged 40 or more years old who took part in the 2005-2008 National Health and Nutrition Examination Survey. The average age of participants was 57 years old, 53 percent of whom were women. A one unit increase in LS7 scores was associated with reduced odds for age-related macular degeneration, diabetic retinopathy, and glaucoma.  "Overall, we believe that primary prevention and early detection approaches of ocular diseases are important, considering that over half of all deaths from ocular diseases and cardiovascular diseases are known to be preventable," commented co-investigators Noah De La Cruz, MPH, and Obadeh Shabaneh, MPH, both from the Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, TX, USA. Since there is a significant overlap of the risk factors for ocular diseases and cardiovascular disease, the investigators recommended that screening for ocular diseases be incorporated into existing clinical and population-based screenings for cardiovascular diseases. "We hope that our study findings will encourage adherence to healthy lifestyles in order to prevent these age-related diseases while also leading to increased collaborations between cardiologists, optometrists, and ophthalmologists in order to better prevent cardiovascular and ocular diseases," noted Dr. Appiah.       Influence of vitamin D supplementation on a baby's gut microbiome Vitamin D supplementation is associated with compositional changes in a baby's microbiome at three months of age University of Alberta, August 20, 2020   New research from the CHILD Cohort Study has shed light on the influence of vitamin D supplementation on a baby's developing gut microbiome.  The study, published in the journal Gut Microbes, found that vitamin D supplementation is associated with compositional changes in a baby's microbiome--notably a lower abundance of the bacteria Megamonas--at three months of age. "Vitamin D plays an important role in early life, supporting bone metabolism and the healthy development of a baby's immune system," said senior author Anita Kozyrskyj, a professor in the Department of Pediatrics at the University of Alberta and a CHILD Cohort Study investigator. "Most infants in North America receive vitamin D, either as a supplement to breastfeeding or as an ingredient in commercial infant formulas, so we wanted to understand the association between vitamin D and the presence or abundance of key bacteria within a baby's intestinal tract." The researchers examined fecal samples taken during home visits from 1,157 infants who are part of the CHILD Cohort Study--a national study that is following nearly 3,500 Canadian children from before birth to adolescence with the primary goal of discovering the root causes of allergies, asthma, obesity and other chronic diseases. They found that direct vitamin D supplementation of infants with vitamin D drops was associated with a lower abundance of Megamonas, regardless of how a baby was fed (breastfed or formula fed). "While little is known about Megamonas in infancy, our previous research suggests there may be a link between this bacterium and asthma or respiratory viral infections, so vitamin D may offer additional benefits for childhood health that should be studied further," added Kozyrskyj, also a member of the Women and Children's Health Research Institute.  The researchers also assessed the association between infant and maternal vitamin D supplementation and the presence of Clostridioides difficile (C. difficile) in a baby's gut. "Some infants carry the diarrhea-causing bacterium C. difficile in their guts without any symptoms. However, when the levels of gut bacteria become imbalanced, this particular bacterium can multiply, causing illness and increasing the susceptibility to chronic disease later in childhood," commented first author Kelsea Drall, an MSc graduate from the U of A and an AllerGen trainee. The study found that nearly 30 per cent of the infants carried C. difficile, but there was a lower incidence of the bacterium among exclusively breastfed infants. However, neither infant supplementation with vitamin D drops nor maternal vitamin D supplementation during pregnancy or after delivery was associated with C. difficile colonization. "Interestingly, maternal consumption of vitamin D-fortified milk was the only factor that reduced the likelihood of C. difficile colonization in infants," added Drall.  According to Kozyrskyj, an infant's gut microbiota undergoes rapid change in early life. Therefore, it is critical to understand the factors associated with microbial communities populating the infant gut during this key developmental period. "Low vitamin D levels have been associated with respiratory syncytial virus (RSV)--a common lung infection among infants--and more recently, susceptibility to COVID-19 disease," she pointed out. "In the CHILD Cohort Study, we have a unique opportunity to follow our study children as they get older to understand how microbial changes observed as a result of dietary interventions may be associated with later health outcomes such as asthma and viral infections."     Ashwagandha linked to better quality sleep and less anxiety Prakruti Hospital (India), August 19, 2020 Ashwagandha, a prominent herb in traditional Indian medicine Ayurveda, continues to gain support from the medical community as studies find how beneficial the herb is for overall wellbeing and health. Previous studies have found the herb helps reduce cortisol levels and boosts testosterone levels in humans, and now researchers have found evidence the herb is linked to better quality sleep and reduced anxiety. One new trial, published in the journal Cureus, discovered that among aging women and men, taking Ashwagandha improved sleep, mental alertness and overall quality of life. For centuries, the herb has been used to promote longevity, health, and rejuvenation, and this new research backs up its traditional use. Older adults enjoyed improved sleep, mental alertness, and overall quality of life The trial involved aging adults between age 65 and 80, and half were give ashwagandha root extract twice a day and the rest were given a placebo. The trial lasted for 12 weeks, and sleep quality, mental alertness, daytime sleepiness, and quality of life were all evaluated before the trial, at four weeks, at eight weeks, and at the end of the 12-week period. Aging adults that were taking the ashwagandha root extra saw significant improvements in physical, social, quality of life, psychological, and environmental aspects of their lives compared to the placebo group. Mental alertness and sleep quality improved in those taking the supplement, too. Those taking ashwagandha tolerated it well, and it was considered beneficial and safe. According to researchers, the study showed improved sleep and a significant improvement in quality of life for elderly individuals taking the extract. They believe taking ashwagandha root extract could be an excellent supplement for aging adults to boost general well-being and improve age-related health problems     Study concludes that treatment of children with asthma, allergic rhinitis and atopic dermatitis should include vitamin D3 Bogomolets National Medical University (Ukraine), August 21, 2020   According to news reporting out of Kyiv, Ukraine, research stated, “The aim:Tostudythedynamicsof thelevelof 25(ON)D, IL-4, IL-10, and IgG in the bloodserum of children with allergicdiseasesandtostudytheclinicaleffectof vitamin D3 administration n different dosage in this category of patients. Materials andmethods: 153 children aged 3-16 with such allergicdiseasesasbronchialasthma, atopicdermatitisandallergicrhinitis havebeen examined.” Our news journalists obtained a quote from the research from Bogomolets National Medical University, “The level of 25(ON) D was determined using the electrochemiluminescence method, while the levels of IL-4, IL-10 and IgG were assessed using enzyme-linked immunoassay. In the contrasting of the initial level of 25(ON)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higherdoses (4,000-5,000 IU) over 2 months, significant difference wasestablishedbetween the indicators by the Friedman criterion (l2=41.211; p

The Gary Null Show is here to inform you on the best news in health, healing, the environment. Green tea ingredient may ameliorate memory impairment, brain insulin resistance, and obesity Northwest A&F University (China), July 28, 2020 A study published online in The FASEB Journal, involving mice, suggests that EGCG (epigallocatechin-3-gallate), the most abundant catechin and biologically active component in green tea, could alleviate high-fat and high-fructose (HFFD)-induced insulin resistance and cognitive impairment. Previous research pointed to the potential of EGCG to treat a variety of human diseases, yet until now, EGCG's impact on insulin resistance and cognitive deficits triggered in the brain by a Western diet remained unclear. "Green tea is the second most consumed beverage in the world after water, and is grown in at least 30 countries," said Xuebo Liu, Ph.D., a researcher at the College of Food Science and Engineering, Northwest A&F University, in Yangling, China. "The ancient habit of drinking green tea may be a more acceptable alternative to medicine when it comes to combatting obesity, insulin resistance, and memory impairment." Liu and colleagues divided 3-month-old male C57BL/6J mice into three groups based on diet: 1) a control group fed with a standard diet, 2) a group fed with an HFFD diet, and 3) a group fed with an HFFD diet and 2 grams of EGCG per liter of drinking water. For 16 weeks, researchers monitored the mice and found that those fed with HFFD had a higher final body weight than the control mice, and a significantly higher final body weight than the HFFD+EGCG mice. In performing a Morris water maze test, researchers found that mice in the HFFD group took longer to find the platform compared to mice in the control group. The HFFD+EGCG group had a significantly lower escape latency and escape distance than the HFFD group on each test day. When the hidden platform was removed to perform a probe trial, HFFD-treated mice spent less time in the target quadrant when compared with control mice, with fewer platform crossings. The HFFD+EGCG group exhibited a significant increase in the average time spent in the target quadrant and had greater numbers of platform crossings, showing that EGCG could improve HFFD-induced memory impairment. "Many reports, anecdotal and to some extent research-based, are now greatly strengthened by this more penetrating study," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.       Medieval medicine remedy could provide new treatment for modern day infections University of Warwick UK, July 28, 2020 Antibiotic resistance is an increasing battle for scientists to overcome, as more antimicrobials are urgently needed to treat biofilm-associated infections. However scientists from the School of Life Sciences at the University of Warwick say research into natural antimicrobials could provide candidates to fill the antibiotic discovery gap. Bacteria can live in two ways, as individual planktonic cells or as a multicellular biofilm. Biofilm helps protect bacteria from antibiotics, making them much harder to treat, one such biofilm that is particularly hard to treat is those that infect diabetic foot ulcers. Researchers at the University of Warwick, Dr Freya Harrison, Jessica Furner-Pardoe, and Dr Blessing Anonye, have looked at natural remedies for the gap in the antibiotic market, and in the paper, 'Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients' published in the journal Scientific Reports today the 28 July, researchers say medieval methods using natural antimicrobials from every day ingredients could help find new answers. The Ancientbiotics research team was established in 2015 and is an interdisciplinary group of researchers including microbiologists, chemists, pharmacists, data analysts and medievalists at Warwick, Nottingham and in the United States. Building on previous research done by the University of Nottingham on using medieval remedies to treat MRSA, the researchers from the School of Life Sciences at University of Warwick reconstructed a 1,000-year-old medieval remedy containing onion, garlic, wine, and bile salts, which is known as 'Bald's eyesalve', and showed it to have promising antibacterial activity. The team also showed that the mixture caused low levels of damage to human cells. They found the Bald's eyesalve remedy was effective against a range of Gram-negative and Gram-positive wound pathogens in planktonic culture. This activity is maintained against the following pathogens grown as biofilms:   1. Acinetobacter baumanii- commonly associated with infected wounds in combat troops returning from conflict zones. 2. Stenotrophomonas maltophilia- commonly associated with respiratory infections in humans 3. Staphylococcus aureus- a common cause of skin infections including abscesses, respiratory infections such as sinusitis, and food poisoning. 4. Staphylococcus epidermidis- a common cause of infections involving indwelling foreign devices such as a catheter, surgical wound infections, and bacteremia in immunocompromised patients. 5. Streptococcus pyogenes - causes numerous infections in humans including pharyngitis, tonsillitis, scarlet fever, cellulitis, rheumatic fever and post-streptococcal glomerulonephritis.   All of these bacteria can be found in the biofilms that infect diabetic foot ulcers and which can be resistant to antibiotic treatment. These debilitating infections can lead to amputation to avoid the risk of the bacteria spreading to the blood to cause lethal bacteremia. The Bald's eyesalve mixtures use of garlic, which contains allicin, can explain activity against planktonic cultures, however garlic alone has no activity against biofilms, and therefore the anti-biofilm activity of Bald's eyesalve cannot be attributed to a single ingredient and requires the combination of all ingredients to achieve full activity. Dr Freya Harrison, from the School of Life Sciences at the University of Warwick comments: "We have shown that a medieval remedy made from onion, garlic, wine, and bile can kill a range of problematic bacteria grown both planktonically and as biofilms. Because the mixture did not cause much damage to human cells in the lab, or to mice, we could potentially develop a safe and effective antibacterial treatment from the remedy. "Most antibiotics that we use today are derived from natural compounds, but our work highlights the need to explore not only single compounds but mixtures of natural products for treating biofilm infections. We think that future discovery of antibiotics from natural products could be enhanced by studying combinations of ingredients, rather than single plants or compounds. In this first instance, we think this combination could suggest new treatments for infected wounds, such as diabetic foot and leg ulcers. " Jessica Furner-Pardoe, from the Medical School at the University of Warwick comments: "Our work demonstrates just how important it is to use realistic models in the lab when looking for new antibiotics from plants. Although a single component is enough to kill planktonic cultures, it fails against more realistic infection models, where the full remedy succeeds." In previous research Christina Lee, from the School of English at the University of Nottingham, had examined the Bald's Leechbook, an Old English leatherbound volume in the British Library, to see if it really works as an antibacterial remedy. The Leechbook is widely thought of as one of the earliest known medical textbooks and contains Anglo-Saxon medical advice and recipes for medicines, salves and treatments. Christina adds: "Bald's eyesalve underlines the significance of medical treatment throughout the ages. It shows that people in Early Medieval England had at least some effective remedies. The collaboration which has informed this project shows the importance of the arts in interdisciplinary research."   First clinical trial of its kind studies whether cannabidiol could help treat cannabis use disorder, compared to placebo University of Bath (UK), July 28, 2020   Prescription medication of cannabis extract cannabidiol, or CBD, is safe for daily use in treating cannabis use disorder, and could help people to cut down on cannabis use, according to an initial randomised controlled trial published in The Lancet Psychiatry journal. The study is the first to report that daily prescribed medical-use CBD use can cause reduction in cannabis use among people with cannabis use disorder, but the four-week study was not designed to provide robust estimates of the magnitude or duration of efficacy and further studies are needed. Researchers found an optimal daily dose of between 400mg and 800mg of CBD, which is considerably higher than concentrations found in CBD products that are available without prescription (which typically contain around 25mg CBD). They warn that such products should not be used for medicinal purposes. The authors say that these findings are important in light of major policy changes surrounding the production and sale of cannabis products, increases in the number of people entering treatment for cannabis use disorders worldwide, and the current absence of recommended treatments for cannabis use disorder. Dr Tom Freeman, the study's lead author and Director of the Addiction and Mental Health Group at the University of Bath, UK, said: "Our study provides the first causal evidence to support cannabidiol, or CBD, as a treatment for cannabis use disorders. This is encouraging, as there are currently no drug treatments for cannabis addiction. CBD products are widely available in many countries but we would not advise people to self-medicate with these products. People with concerns about their cannabis use should always speak to a healthcare professional in the first instance." [1] Cannabis addiction affects an estimated 22 million people worldwide - similar to the prevalence of opioid use disorders - and the proportion of people seeking help for cannabis use disorders has risen in all world regions apart from Africa. However, there are currently no medications recommended for the treatment of cannabis use disorders. Cannabidiol, also known as CBD, is one of more than 80 chemicals present in cannabis. By itself, CBD has been reported to induce feelings of relaxation and calm, but it does not cause the "high" associated with cannabis use, which is caused by a different chemical called tetrahydrocannabinol, or THC. As a result, CBD is sold legally in many countries in oils, capsules, creams, tea and other products. Previous studies have suggested that taking CBD products could help to reduce withdrawal symptoms in people who are actively trying to quit cannabis use. However, it hasn't been possible to determine whether these effects were due to CBD, because the studies either used an open-label design (where the participants knew what medications they were taking and so the results could have been biased), or CBD was given together with THC so it wasn't possible to say to which chemical the effects were attributable. In this latest study, researchers carried out the first randomised clinical trial of cannabidiol for the treatment of cannabis addiction. All 82 people who took part in the study had been diagnosed with a cannabis use disorder of at least moderate severity, which means they experienced at least four out of 11 possible symptoms of addiction. They had all expressed a desire to quit within the next month, and had tried to quit on at least one occasion before. Participants were randomly assigned to treatment groups and asked to take two capsules of CBD twice daily for four weeks. The placebo group were given sham capsules containing no CBD, while the others received a daily dose of either 200mg, 400mg or 800mg CBD. All of the participants received six counselling sessions designed to help them quit using cannabis, which took place before and during the study period. Weekly urine samples were tested for levels of THC to assess how much cannabis had been consumed in the past week. Participants were also asked to report how many days they had abstained from using cannabis that week. The trial used an adaptive design to identify which doses of CBD were effective or ineffective compared to placebo. In the first stage of the trial, 12 people per group were assigned to either placebo, 200mg, 400mg or 800mg CBD (48 total). After the first phase of the study, the 200mg dose was found to be ineffective and these participants were removed from the trial. A further 34 people were recruited to the second stage of the study and randomly assigned to receive daily doses of either the placebo (11 people), 400mg CBD (12 people) or 800mg CBD (11 people). Daily CBD doses of 400mg and 800mg were both found to reduce participants' cannabis intake (reducing THC levels in the urine by -94.21ng/mL and -72.02ng/mL, respectively). In addition, abstinence from cannabis use increased by an average of 0.5 days per week in the group who received the 400mg daily dose of CBD and 0.3 days per week in the group who received 800mg CBD daily. The researchers observed no difference in side effects experienced by the placebo group and those receiving any dose of CBD. 77 of 82 participants completed the treatment and those who dropped out did so because of missing study visits, being lost to follow up, not taking the study medication, or taking additional medications, and not because of the CBD treatment. There were no serious adverse events during the study, suggesting that CBD is safe and well tolerated at the doses tested. Professor Valerie Curran, senior author and Director of the Clinical Psychopharmacology Unit at University College London, UK, said: "Our findings indicate that CBD doses ranging from 400mg to 800mg daily have the potential to reduce cannabis use in clinical settings, but higher doses are unlikely to bring any additional benefit. Larger studies are needed to determine the magnitude of the benefits of daily CBD for reducing cannabis use." [1] The study was carried out over a four week treatment period with follow up extending to six months. The researchers say additional research is needed to investigate the extent to which their findings translate to different durations of treatment. Studies are also needed to investigate whether CBD directly reduces cannabis use or if it reduces other mental health symptoms which might indirectly affect cannabis use, such as anxiety.   Pessimistic outlook on life linked to life expectancy QIMR Berghofer Medical Research Institute (Australia). July 28, 2020   A new QIMR Berghofer Medical Research Institute study has found people who are strongly pessimistic about the future are at greater risk of dying earlier than those who are not pessimists. The researchers also found, however, that being an optimist did not extend life expectancy. The lead researcher, Dr. John Whitfield from QIMR Berghofer's Genetic Epidemiology group, said study participants who scored higher on pessimism in a questionnaire were likely to die on average two years earlier than those with low scores. "We found people who were strongly pessimistic about the future were more likely to die earlier from cardiovascular diseases and other causes of death, but not from cancer," Dr. Whitfield said. "Optimism scores on the other hand did not show a significant relationship with death, either positive or negative. "Less than nine percent of respondents identified as being strongly pessimistic. There were no significant differences in optimism or pessimism between men and women. On average, an individual's level of either optimism or pessimism increased with age. "We also found depression did not appear to account for the association between pessimism and mortality." The researchers used data collected from almost 3,000 participants who completed the Life Orientation Test as part of a broader questionnaire that looked at the health of Australians aged over 50 between 1993 and 1995. The participants were invited to agree or disagree with a number of statements including positive statements such as, 'I'm always optimistic about my future' or negative statements such as, 'If something can go wrong for me, it will'. The participants' details were then cross checked with the Australian National Death Index in October 2017 to find out how many people had died and their cause of death. (More than 1,000 participants had died.) Previous studies have shown a correlation between optimism and pessimism and specific diseases such as cardiovascular disease or stroke, but most previous studies also put optimism and pessimism on one scale. This resulted in people who received low scores on the pessimism questions being classed as optimists, but Dr. Whitfield said that was not always an accurate reflection of people's outlooks. "Optimism and pessimism are not direct opposites," Dr. Whitfield said. "The key feature of our results is that we used two separate scales to measure pessimism and optimism and their association with all causes of death. "That is how we discovered that while strong pessimism was linked with earlier death, those who scored highly on the optimism scale did not have a greater than average life expectancy. "We think it's unlikely that the disease caused the pessimism because we did not find that people who died from cancer had registered a strong pessimism score in their tests. If illness was leading to higher pessimism scores, it should have applied to cancers as well as to cardiovascular disease." Dr. Whitfield said the research findings raised questions about the practical health benefits of training people out of pessimism. "Understanding that our long term health can be influenced by whether we're a cup-half-full or cup-half-empty kind of person might be the prompt we need to try to change the way we face the world, and try to reduce negativity, even in really difficult circumstances." The study findings have been published this week in the journal Scientific Reports.   Wealthier men are more likely to develop high blood pressure Hokkaido University Graduate School of Medicine (Japan), 26 July 2020:    Working men with higher incomes are more likely to develop high blood pressure, reports a study presented at the 84th Annual Scientific Meeting of the Japanese Circulation Society (JCS 2020). JCS 2020 takes place online from 27 July to 2 August in conjunction with the Asian Pacific Society of Cardiology Congress 2020 (APSC 2020). Joint scientific sessions are being held by the European Society of Cardiology (ESC) and JCS as part of the ESC Global Activities programme.1 "Men with higher incomes need to improve their lifestyles to prevent high blood pressure," said study author Dr. Shingo Yanagiya of the Hokkaido University Graduate School of Medicine, Sapporo, Japan. "Steps include eating healthily, exercising, and controlling weight. Alcohol should be kept to moderate levels and binge drinking avoided." More than one billion people have high blood pressure worldwide.2 Around 30-45% of adults are affected, rising to more than 60% of people over 60 years of age. High blood pressure is the leading global cause of premature death, accounting for almost 10 million deaths in 2015. Of those, 4.9 million were due to ischaemic heart disease and 3.5 million were due to stroke. Japan alone has more than 10 million people with high blood pressure, and the number continues to rise. Dr. Yanagiya said: "High blood pressure is a lifestyle-related disease. As a physician seeing these patients I wanted to know if risk varies with socioeconomic class, to help us focus our prevention efforts." This analysis of the J-HOPE3 study examined the relationship between household income and high blood pressure in Japanese employees. A total of 4,314 staff (3,153 men and 1,161 women) with daytime jobs and normal blood pressure were enrolled in 2012 from 12 workplaces. Workers were divided into four groups according to annual household income: less than 5 million, 5 to 7.9 million, 8 to 9.9 million, and 10 million or more Japanese yen per year. The researchers investigated the association between income and developing high blood pressure over a two-year period. Compared to men in the lowest income category, men in the highest income group were nearly twice as likely to develop high blood pressure. Men in the 5 to 7.9 million and 8 to 9.9 million groups had a 50% higher risk of developing high blood pressure compared to men with the lowest incomes, although the positive association did not reach statistical significance in the 8 to 9.9 million group. The findings were consistent regardless of age, and were independent of baseline blood pressure, worksite, occupation, number of family members, and smoking. The relationships were slightly weakened after accounting for alcohol consumption and body mass index (BMI; kg/m2), both of which were higher for men in the higher income groups. In women, there was no significant link between income and blood pressure. However, women with higher household income tended to have a lower risk of developing high blood pressure. "Some previous Japanese surveys have reported that higher household income is associated with more undesirable lifestyles in men, but not in women," said Dr. Yanagiya. "Our study supports this: men, but not women, with higher household incomes were more likely to be obese and drink alcohol every day. Both behaviours are major risk factors for hypertension." He concluded: "Men with high-paying daytime jobs are at particular risk of high blood pressure. This applies to men of all ages, who can greatly decrease their chance of a heart attack or stroke by improving their health behaviours." Dr. Yusuke Yoshikawa, public relations coordinator for JCS 2020, said: "Hypertension is one of the most important risk factors of cardiovascular disease in Japan, because the average daily salt intake in Japan (approx. 10 g/day) is much higher than desired. As the current guidelines2 strongly recommend healthy lifestyle to control high blood pressure, this study suggests a potential key to successful intervention for those who are at risk of heart disease and stroke." Professor Michel Komajda, a Past President of the ESC and course director of the ESC programme at JCS 2020, said: "The ESC is delighted to be part of JCS 2020 in Kyoto. We value our special partnership with JCS and the high quality of Japanese research. Japan is among the top submitters of abstracts to ESC Congress."   Acute exercise has beneficial effects on the immune system during prostate cancer Victoria University (Australia), July 28, 2020   New research published this week in Experimental Physiology found that in prostate cancer survivors, a moderate bout of exercise kept the cell count of certain type of immune cells at a normal level, suggesting the exercise is safe for prostate cancer survivors. After 24 hours after a moderate bout of cycling, the immune cell count of natural killer (NK) cells, part of the body's first line of defence, had returned to resting levels. Prostate cancer treatments, including androgen deprivation therapy (ADT), have numerous adverse effects that reduce physical function and quality of life. Exercise is recommended for cancer survivors to reduce the side effects of treatment and has shown to have many benefits. However, the effects of prostate cancer treatment and acute exercise on the immune system have only been briefly examined. Exercise oncology guidelines were initially based on the responses seen in healthy, older adults. But individuals with cancer have different physiological responses to exercise, many of which we are only just beginning to understand. Exercise helps the immune system mobilise by causing NK cells to move into the blood and be transported them to areas of need, such as sites of infection or tumours. At the tissues, these cells move out of circulation and in cancer patients they can the infiltrate the tumour and potentially slow the tumour's rate of growth. This has been shown very elegantly in animal models but the exercise and immune response in cancer survivors is limited, with only a few studies in prostate cancer. The researchers, based at Victoria University in Australia, had volunteers (11 cancer survivors currently receiving ADT treatment, and 14 men with prostate cancer not on ADT, and 8 healthy controls) completed a cycling task to determine their maximal aerobic fitness. The researchers chose to use a moderate intensity exercise session that was consistent with current exercise oncology guidelines but was also a bout that would be practical for prostate cancer survivors to perform on their own. To ensure that the exercise bout used to stimulate the immune system was the same degree of difficulty for everyone, they standardised based on their maximal effort. To determine immune function, they obtained blood samples before exercise, immediately after and 2h after they finished cycling. The participants then came back the next day (24h) after exercise, and immune function was assessed again after one night of recovery. They also measured several key hormone levels, including adrenaline and noradrenaline, as they play a role in activating and mobilising the NK immune cells. The researchers found that 24 hours after a moderate bout of cycling, the immune cell count of natural killer (NK) cells, part of the body's first line of defence, had returned to resting levels. They also showed that the immune cell mobilisation with exercise does not appear to be significantly altered during prostate cancer treatment, which provides direct evidence that acute exercise that falls within current oncology guidelines also appears to be beneficial for the immune system. A limitation of the study is the modest sample size, and also that they examined cytokines and proteins that are related to NK cell function but did not directly assess the killing capacity of the NK cells. Erik D Hanson, first author on the study said, "One of the most enjoyable aspects of working with these men is how willing these men are to help their fellow prostate cancer survivors. Many of them realise that these studies are not likely to benefit them directly. However, they do not hesitate to volunteer and are willing to do just about whatever is asked of them for the collective good."   Study shows mango consumption has positive impact on inflammatory bowel disease Texas A&M University, July 29, 2020  Initial results of a study by researchers in the department of nutrition and food science at Texas A&M University in College Station show mango consumption has a positive impact on people with inflammatory bowel disease. Dr. Susanne Talcott, Texas A&M AgriLife Research scientist, and others recently investigated the use of fresh mangoes as an adjuvant to conventional therapy in mild to moderate inflammatory bowel disease. "Inflammatory bowel disease presents a major risk factor for colon cancer with the most common forms of this disorder being Crohn's disease and ulcerative colitis," Talcott said. "Previous studies indicate that IBD affects about 1.5 million individuals in the U.S., about 2.2 million in Europe and many more in other countries." "Colorectal cancer can develop from precursor lesions that can be caused by inflammatory bowel disease over periods of 10 to 15 years, which provides an extended time for preventive measures," she said. Talcott said multiple studies have demonstrated the health benefits of secondary plant compounds in fruits and vegetables including pomegranate, citrus and curcuminoids, and polyphenolics have been found to reduce inflammatory processes in chronic diseases such as cardiovascular disease, cancer and inflammatory bowel diseases. "However, few human clinical studies using polyphenolics in the treatment of inflammatory bowel disease have been conducted," she said. Mangos are rich in gallotannins, a group of large molecular polyphenols that can be broken down to small, absorbable, bioactive molecules by certain intestinal bacteria. To investigate the impact of mango polyphenolics on humans, Talcott's team, which included husband Dr. Stephen Alcott, also an AgriLife Research scientist, designed a clinical trial conducted at Texas A&M. Trial subjects were recruited in the College Station area and at the Ertan Digestive Disease Center at the Memorial Hermann Hospital in Houston under the direction of Dr. Andrew Dupont, MD. The study was designed as a controlled clinical pilot trial in subjects with mild-to-moderate active Crohn's disease or mild-to-moderate ulcerative colitis. Subjects ate mango as an adjunct to their common drug treatment for mild-to-moderate IBD. Male and female individuals from 18 to 79 years old with Crohn's disease or ulcerative colitis were enrolled in the study. Those included were individuals undergoing current or previous IBD drug treatment within the past six months and those on a stable drug regimen for at least three weeks before the start of the treatment phase of the study. Excluded from the study were those with chronic health conditions or recurrent hospitalizations, as well as those who smoked more than one pack of cigarettes per week, had a current liver or renal dysfunction, were pregnant or lactating or had a known lactose intolerance, gluten sensitivity or celiac disease. Also excluded were those with planned or scheduled IBD-related surgery, current IBD-related intestinal stricture, current infection with C. difficile or a previous bowel resection. Medical personnel evaluated more than 300 subjects for the study based on medical records or surveys. Twenty subjects participated in some aspect of the study, including the screening, with 14 completing the study. Subjects were provided with and asked to include 200-400 grams of commercially available frozen mangos of the Keitt variety in their daily diet. They were asked to increase their mango consumption slowly over the first week. "Since the tolerability of large amounts of fiber-rich fruit varies between subjects and for each patient over time, this study allowed subjects to consume mango within a range rather than a fixed amount," Talcott said. "This range was from 200 grams twice daily to 400 grams three times a day." She said subjects could skip their mango consumption or reduce it to accommodate any possible digestive issues, but were required to document their daily mango intake. Subjects who underwent an endoscopy before the beginning of this study were asked to wait at least one week before the study treatment could be started. The treatment phase of the study was eight weeks. "Despite a relatively small subject number, this study yielded significant findings and several biomarkers would have been significantly reduced with a higher number of subjects," Talcott said. She said symptoms of ulcerative colitis were significantly reduced in the test subjects and several biomarkers associated with inflammation were decreased after eight weeks of mango consumption. Additionally, the presence of GRO, a molecule associated with colon cancer growth, was significantly reduced. "Intestinal Lactobacilli and other beneficial probiotic bacteria were significantly increased after the consumption of mango as were certain short-chain fatty acids essential for a healthy intact intestinal tract," she said. Talcott said high endotoxin levels are not only associated with intestinal inflammation but also with other chronic inflammatory diseases, but after eight weeks of mango consumption, high endotoxin levels in blood plasma were significantly decreased. "Taken together, our results indicate mango intake exerted beneficial effects in the progression and severity of the IBD after eight weeks of nutritional intervention," she said. She noted mango consumption might also mitigate inflammation in part by improving the composition of the intestinal microbiota and decreasing the serum endotoxin level. "All subjects who completed the study stated they would continue to consume mangoes regularly and will recommend this to others who suffer from IBD and also tell their physicians," Talcott said. She said if mango or any other polyphenolic-rich food can be identified as helpful in shortening or reducing severity of episodes of inflammatory bowel disease, the addition of mango polyphenolics to conventional IBD drug treatment could have a significant positive impact on public health.   Meta-analysis supports potential of omega-3s for ADHD Kings College London, July 28, 2020 Omega-3s fatty acid supplements may improve symptoms and cognitive performance in children and adolescents with attention deficit hyperactivity disorder (ADHD), according to a meta-analysis of gold standard clinical trials. Data from seven clinical trials involving over 500 children and adolescents indicated that omega-3s were associated with improvements in clinical symptoms of ADHD, while data from three clinical trials involving over 200 children and adolescents indicated a positive impact on cognitive measures associated with attention. “[W]e provide strong evidence supporting a role for n3-PUFAs deficiency in ADHD, and for advocating n-3 PUFAs supplementation as a clinically relevant intervention in this group, especially if guided by a biomarker-based personalization approach,” wrote the authors, led by Jane Pei-Chen Chang from King's College London, in Neuropsychopharmacology . Boosting EPA/DHA intakes Commenting independently on the meta-analysis, Harry Rice, PhD, VP of regulatory & scientific affairs for the Global Organization for EPA and DHA Omega-3s (GOED): “In the past, I've been lukewarm on whether or not increasing EPA/DHA intake benefits children with ADHD. Results from this meta-analysis put me a little closer to believing. “Minimally, given the low side effect profile of omega-3s versus the drugs of choice to treat ADHD, I would highly recommend first increasing intake of EPA/DHA. This is particularly true if a child doesn't eat at least two servings of fatty fish a week or doesn't take an omega-3 supplement on a regular basis.” Meta-analysis details The new meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and used established scientific literature databases to identify appropriate studies for inclusion. Data from seven randomized controlled trials (RCTs) with 534 young people indicated that that omega-s3 supplementation significantly improved inattention and hyperactivity symptoms, according to parental reports. Additional analysis revealed that the improvements in hyperactivity were only observed when doses of EPA (eicosapentaenoic acid) of 500 mg/day or more were used. Interesting, the researchers did not find improvements in hyperactivity and inattention when they looked at teacher's reports, unlike what was reported by parents. Omega-3 supplements were associated with improvements in select measures of cognitive performance, said the researchers. “N-3 PUFAs are crucial for optimal neurotransmitter function: for example, incorporating more EPA and DHA in the cell membrane can increase cholesterol efflux, modulate lipid raft clustering and disruption, and affect the function of the dopamine transporter (DAT), which in turn may affect attention and executive function by regulating synaptic dopamine levels,” wrote the researchers. Omega-3 levels Data from case-control studies were also collected to assess if omega-3 levels were also associated with ADHD, with results indicating that children and adolescents with ADHD had lower levels of EPA, DHA (docosahexaenoic acid),and total omega-3s. “In the context of ‘personalised medicine', it is tempting to speculate that a subpopulation of youth with ADHD and with low levels of n-3 PUFAs may respond better to n-3 PUFAs supplementation, but there are no studies to date attempting this stratification approach,” wrote the researchers. “However, we have [previously] shown that individuals at genetic risk of developing depression in the context of the immune challenge, interferon-alpha (IFN-alpha), have lower levels of RBCs n3-PUFAs, and that n-3 PUFAs supplementation prevents the onset of IFN-alpha-induced depression, arguably by replenishing the endogenously low anti-inflammatory PUFAs in the ‘at risk' individuals.”

This episode is brought to you by the great folks at Summit 420, the "Best of the Best" business event in the Young President's Organization. Learn more at www.ypo.org/Summit4202020Ben Chiarelli is the founder and CEO of Cellibre, a cellular agriculture company that is engineering cells to manufacture cannabinoids at industrial scale. Soon they'll be as prevalent and as inexpensive as vitamins. But at what cost?What if I were to tell you that in the next five years medicines and supplements made with cannabinoids will be 1/10th the price -- that $60 bottle of CBD will cost $6. They’ll be labeled “organic” or “natural” and they’ll deliver consistent measurable doses -- no more take a half a dropper and see what happens. And that all this will go a long way to diminishing the stigma currently associated with cannabis-based medicines—that that they’re for stoners or will lower IQ, permanently kill memory cells or drive you to harder drugs (all unfounded myths, btw). Now, what if I told you that these inexpensive cannabinoids will not be coming from a plant grown in the ground and fed by water and sun. That they are being industrially developed in a lab and will be produced in vats by biologists who are engineering the genetic structure of microbes like algae, yeast or E. Coli so that they produce and excrete cannabinoids. (That’s right, algae poop. If what the algae is fed is organic, the FDA may deem its excrement “natural” or “organic” no matter what is done to modify its genetic code). That they will being fermented in huge, 10,000 liter steel containers the size of grain silos. Oh, and if this sounds unimaginable consider that most of the vitamins you take today are made exactly in the same way. (You don’t really think there is enough cod in the ocean to produce all of that DHA Omega 3 fish oil do you?) And that this method of product could save billions of dollars in energy costs since indoor grows will soon be going the way of the coal fired steel factory). All of this is underway. There are at least 20 well-funded cellular agriculture companies currently bio-engineering cannabinoids, and this podcast features Ben Chiarelli, CEO and founder of Cellibre, based in San Diego, CA.To me, the implications of industrially produced cannabinoids are in equal parts thrilling and terrifying. The idea of Monsanto getting its claws into cannabis and creating GMO crops – Armageddon or at the very least, Soylent Green to many aficionados – is not a calming thought. And this new approach using microbes to make these medicines may be even more off putting. At the same time affordable cannabinoid meds will be a blessing to people with chronic illnesses. Remember, a month’s supply of the CBD you’re using today costs more than your leased car. And if they create predictable, clean and measurable formulations, well, that’s a future that most health care providers and patients would welcome. Please listen to this podcast and let me know what you think. Send comments to bravenewweedcast@gmail.com. I’m going to be exploring this topic for a long time – it’s a big one -- and I’m just starting to get my mind around it.

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:  Simon: Hi Stephen. Thanks so much for the amazing service you provide to us all! I discovered you a couple of months ago and have been binge-listening and reading you book ever since. My wife and I have blastocystis and my wife also has dientaboeba. Whilst I am doing the parasite protocol and others, my wife is doing two courses of Paromomycin (as she has a limited amount of time and wants the most effective result). Putting aside the question of whether she is making the right decision (I would prefer she avoided antibiotics), I am hoping to add to minimise the negative effects whilst maxamizing the effectiveness of her treatment. I was wondering: a) whether the a biofilm disruptor would assist with treating blasto with antibiotics, and if so should she take before or during treatment? b) would the CBO protocol approach to probiotics be appropriate after antibiotics? I.e populate with saccharomyces boulardii before/during/one month after; then acidophilus bifidus; then a broad spectrum? Note she wont do the CBO protocol as we will be trying for a baby shortly after the antibiotics. I am also feeding us a diet rich in antiparasitics (clove, cinnamon, garlic, pumpkin seeds) and have suggested she do the 7-14 day detox before treatment. I'd love your thoughts on the above and any related issues. Thanks so much and ayubowan! Cheryl: Hi Dr. Cabral, I am on week 2 day 3 of your 21 detox. I have lost 12 pounds to date- simply amazing!!! I waited too long between meals (4 hours). 2 times I noticed a sweet taste in my teeth just before my meal. Once I eat it goes away. What is the reason for the sweet taste??? Just note my brain fog melted away, I have had a surge of energy since week one day 3. So I have been very active not excercising but cleaning and moving-I surpassed my 10k steps on the detox!!!!. I am looking forward to taking your courses and my future lab tests. Much gratitude on my journey towards wellness.Cheryl Ryan: Hello Dr. Cabral, thanks for taking the time to answer questions! I have listened to many of your podcasts regarding histamines. To keep things short, I just wanted to know the difference between taking a supplement like Histpro and a supplement containing diamine oxidase? I realize rebalancing the gut, removing any overgrowth, etc is working more towards figuring out the root cause. But my question is for relief in the short term while you are healing. I realize the Histpro has multiple good componenets like quercetin, vitamin C, etc. Just wanted to know what would be stronger or more beneficial in short term, of course assuming you are eating a lower histamine diet and the whole lifestyle approach. Thanks, Ryan Cara: Hi Dr. Cabral! After 23 years of wearing contacts, I'm going in for Lasik in January. It took me a long time to come to this decision, but now the technology is amazing and we have an exceptional doctor here in So Cal. Prior to the procedure, they have you take an eye supplement as well as a fish oil. I asked the amounts of DHA/EPA/Omega 3's required and the reply was that their supplement has "DHA Omega-3 at least 800mg and total Omega-3’s 2000mg." It looks like EN's fish oil surpasses that requirement with a total of 2.6g of total Omegas. Do you have an eye supplement that you would recommend with the lutein and zeaxanthin? Cara: Hi Dr. Cabral, Did you catch Ben Greenfields interview of Dr. Tan and his research on Vitamin E? He claims that tocopherols are toxic and that tocotrienols are the form of Vitamin E that is most beneficial? It was a very interesting podcast and I'm Curious your thoughts on this. Thank you! Maurice: Hello Dr. Cabral, I'm 29 and was diagnosed with multiple sclerosis approximately one year ago. I decided to decline conventional treatment after being inspired by my brother Kevin, who is also an IHP 1&2. Since, I've conducted quite some research and have nearly perfected my diet, consisting of very low amount of saturated fat and processed foods, a regular Omega 3 intake, and mainly plant based meals (except for one weekly cheat meal). I work out regularly, do the sauna, and get my daily D3. I listen to your podcast regularly and find your advice very beneficial! I'm currently on the 7-Day Detox and am doing the CBO protocol right after Thanksgiving. I do plan on having the labs done, BUT the way my bank account is set up...Overall I feel good, but am deathly scared to relapse again and the thought of deteriorating. Do you have any additional lifestyle/diet suggestions? Also, is Iherrmitte's Sign (the brief, intense tingling sensations shooting down my spine when I tilt my head) reversible? Lastly, I recently heard of the angioplasty aka liberation therapy for the Chronic Cerebrospinal Venous Insufficiency (CCSVI) treatment, which has been shown to provide drastic improvements to MS patients. What is your knowledge and take on it?Thank you so much for sharing your expertise and your continuous inspiration! Very respectfully, Maurice   Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community’s questions!  - - - Show Notes & Resources: http://StephenCabral.com/1429 - - - Get Your Question Answered: http://StephenCabral.com/askcabral   - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)

BIG NEWS!!! The FDA just approved the first fish oil "drug" for heart health! Testing on this new "drug" showed reduced risk of deadly heart complications by 25%! In the history of heart health there has NEVER been a drug that reduced the risk of heart attack and stroke by 25%. The great news about this "drug"? It's basically Omega 3!! In today's podcast, Dr.Martin discusses this new "drug." He also discusses how to lower triglycerides and how DHA/Omega 3 work. If you're taking medication for heart health, you don't want to miss this episode!

The Omega-3 Clinical Study Database, now in phase 2 data extraction, will one day be a searchable database of human clinical trials that examined the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), or the combination of those two long-chain omega-3s. GOED (The Global Organization for EPA and DHA Omega-3s) started this endeavor two years ago, as Ellen Schutt, executive director, explains in this Healthy Insider Podcast, and has narrowed down 35,000 potential studies into 4,000 specifically focused on EPA/DHA that need to be categorized for demographics, dosage, intervention and outcome.

Wir sprechen heute über das Thema Radfahren im Winter. Wie motiviert man sich, welche Ausrüstung braucht man. Was mache ich gegen kalte Hände und kalte Füße? Welche Kleidung empfehlen wir? Und dann die Beleuchtung auf der Straße und im Gelände. Dazu natürlich viele kleine andere Fragen & Antworten und Fundstücke. DAS NEUE T-SHIRT! Hier im Shop ansehen: https://www.enjoyyourbike.com/Outdoor-Camping-Wandern/Enjoyyourbike-Freizeitshirt-aus-Bio-Baumwolle-Grau-Gr-L::13836.html NEU! Ab heute mit ungefähren Minuten-Angaben zu den Themen: —————— MINUTE 0: Intro, Luftdoping, Feedback Sardinien, Rückenschmerzen auf dem Rad —————— Luftdoping: https://www.welt.de/print/die_welt/hamburg/article119640006/Luft-Doping-in-den-70er-Jahren.html Sardinien Touren (und andere):  www.der-cyclist.com —————— MINUTE 29: Dan und der Elemnt Roam —————— —————— MINUTE 37: Lackfolie beim Bikepacking? —————— —————— Minute 45 Draußen oder drinnen trainieren, Motivation? —————— Rapha 500: https://www.rapha.cc/de/de/stories/festive-500 Ursprünglich 1000 km durch Graeme Raeburn: https://www.radsport-news.com/freizeit/freizeitnews_78959.htm —————— Minute 1:03: Welche Strecken - im Wald, Straße? —————— —————— Minute 1:13: Das Winterrad: Schutzbleche, Radpflege, etc. —————— Crud RoadRacer Schutzbleche: https://www.enjoyyourbike.com/Schutzbleche/Crud-RoadRacer-MK3-Schutzblech-Set-fuer-Rennraeder-Gravelbikes-und-Crossraeder::12343.html Film zu den Cruds: https://www.youtube.com/watch?v=WVsgmMqKLSg Der berühmte mobile Kärcher: https://amzn.to/2N0nGnN (Amazon Affiliate Link) Stihl Handsprüher für MucOff: https://amzn.to/2WqJYBZ (Amazon Affiliate Link) Ass Saver für das MTB oder OPEN: https://amzn.to/2JA0TNh (Amazon Affiliate Link) —————— Minute 1:26: Wichtig: Essen! Schokolade? —————— —————— Minute 1:30: Kalte Hände? Kalte Füße? Kleidungs-Strategien —————— Specialized Defroster Winterschuh: https://www.enjoyyourbike.com/Mountainbikeschuhe/Specialized-Defroster-Trail-MTB-Schuh-reflektierend-Gr-36::13777.html 30seven beheizbare Handschuhe: https://www.enjoyyourbike.com/Fahrradhandschuhe/30seven-beheizbare-Fahrradhandschuhe-Race-Waterproof-Groesse-6-2XS::13133.html ioMerino: https://iomerino.com/ Akustika Watte für die Ohren: https://amzn.to/2ovmUWp (Amazon Affiliate Link) —————— Minute 2:11: Pendeln im Winter - Alltagskleidung? —————— DU/ER Jeans: https://www.enjoyyourbike.com/DU-ER:.:414.html —————— Minute 2:15: Fahrradbeleuchtung —————— Lupine (Links zu unserem Shop folgt, sobald online) Lunivo Lampen (günstig und gut): https://www.enjoyyourbike.com/Lunivo:.:425.html Lezyne Lampen: https://www.enjoyyourbike.com/Lezyne:.:324.html —————— Minute 2:42: Picks —————— Dan: Stihl Handsprüher für MucOff: https://amzn.to/2WqJYBZ (Amazon Affiliate Link) Satellite Telefonnummer: https://www.satellite.me/ YR App: https://apps.apple.com/us/app/yr-no/id490989206 Ingo: Leinöl mit DHA Omega-3 Fettsäuren: https://amzn.to/2JyCwQg (Amazon Affiliate Link) _________________________________________________________ Hier findet Ihr überall unseren Podcast zum Herunterladen! _________________________________________________________ 1. iTunes Hier der direkte Link zu unserem Podcast auf dem iPad, iPhone, Mac (iTunes): https://podcasts.apple.com/de/podcast/enjoyyourbike-der-radsport-triathlon-talk/id1465087792 2. Spotify Hier findet Ihr den Podcast bei Spotify: https://open.spotify.com/show/5LXBbG8fif3aXcB3dS2PyS 3. Google Hier findet Ihr den Podcast in der Google Podcast App: https://www.google.com/podcasts?feed=aHR0cHM6Ly9lbmpveXlvdXJiaWtlLnBvZGlnZWUuaW8vZmVlZC9tcDM%3D 4. Deezer Hier findet Ihr den Podcast bei Deezer: https://www.deezer.com/de/show/364362 5. Direkte Links: Hier der Link zu unserer Podcast-Seite bei Podigee. Hier könnt Ihr z.B. MP3 direkt herunterladen: https://enjoyyourbike.podigee.io/ 6. Unser Podcast bei Youtube mit Video! (komplette Playlist): https://www.youtube.com/playlist?list=PLCLnrkmezkJR3Myov4To9yl1Wb4_OSTyb _____________

What’s the best way to fulfill the omega-3 essential fat requirements?

Niche Radio — Blankets from Africa [ FB ], from harsh environments, can come beautiful things. A vast semi-desert was known as the Karoo, a land of stark beauty, natural light and darkness enabling an intuitive touch and connection to the electric and magnetic fields of nature. Why is lamb amazing, apart from its consumption of being the second richest source of DHA (Omega 3 life source for our semiconductors), apart from seafood, the wool holds an additional photon barcode relationship to the Sun. This is partly why the fabric is such great material at helping entrap infrared light emitted from our bodies while allowing it to breathe. Listen to the show and submit your answer to jameslechconsulting@gmail.com for a Blankets from Africa prize hamper. Patreon members, get an additional two entries, plus access to loads of specials and special elaborations into the science [ patreon.com/jameslech ] blanketsfromafrica.co.za

Welcome back to this week’s #FridayReview where we’re going to be catching up on some exciting announcements, and our super nutrient of the week! First up, I’m excited to share with you a brand new extraction process that is now allowing far the highest quality, organic, Full spectrum CBD oil in the world! I also want to detail what exactly “Full-Spectrum” Cannabinoids are and how certain ones have been successfully used to heal over 100 mental & physical health ailments...   Keeping with our monthly health challenge I have a brand new quick tip on how to cut back on more plastic waste many of us unknowingly contribute to every week... And finally, I want to take you through the healing powers of two specific types of omega-3 fatty acid‘s that can dramatically reduce inflammation, calm joint pain, and improve mood...   Check out today’s Cabral concepts 826 for all the details, tips, and resources – enjoy the show!   - - -  Show Notes & Resources: http://StephenCabral.com/826 - - - Get Your Question Answered: http://StephenCabral.com/askcabral  

In this episode we discuss how to build a rockstar brain. We get into the neurochemical compositions that create moods from happiness to depression and look at you can change the building blocks of the neurochemicals by changing your diet and your habits. In a world were people are more stressed than ever, sleeping less, and trying to do more - we look at the causes of “brain drain” and what we can do to have physically happier and more productive brains with Dr. Michael Dow.      Dr. Michael Dow is a psychotherapist, neurotherapist, and a New York Times Bestselling author. He has been the host of several television series examining relationships, brain health, addiction, and mental illness. Dr. Mike is frequently a guest cohost on The Doctors and his work has been featured in Today, Good Morning America, Nightline, and more.      Your brain is being drained every day by stress, life, etc  The 3 subtypes of brain drain Adrenaline Norepinephrine Cortisol What happens, neurologically, when you suffer from “brain drain” or brain fog The brain balancing neurochemicals that are the antidotes to stress hormones EPA and DHA Omega 3 Acids - and why they are important co-factors in building a healthy brain People are feeling more stressed than ever, working more, sleeping less How are we causing “brain drain” with our daily habits and activities? The 24 hour relationship between cortisol and melatonin Throughout the day, your melatonin level rises and your cortisol level decreases What we do every single day has a far more profound effect on our neurochemicals than we even realize Lifestyle interventions you can implement to rebalance and change your neurochemicals Sugar and flour drain and shrink the hippocampus - which is the main site of neurogenesis How do we cultivate GABA? Glutamine from spinach Vitamin B6 in bananas, magnesium and zinc Eat seven servings of whole fruits and vegetables every day Are vitamins and supplements are useful tool or should we get all our nutrients from whole foods? The importance of getting Omega-3 fatty acids (EPA and DHA) EPA = Feel Better Omega 3 (stress less Omega 3) DHA = Sleep soundly Omega 3 (promotes restful sleep) EPA and DHA compete for space in your cells Omega 3s are one of the best foods you can eat for your brain - they are the building blocks of yo You can build a “rockstar brain” with a modified mediterranean diet Lean protein Nuts Olive Oil Fish Lots of fruits and vegetables The modified mediterranean diet has been shown via research to combat major depressive disorder Common sources of omega 6 fats - soybean oil and factory farmed meat products - most intense source of omega 6 fats which cause brain inflammation Strategies for shifting the brain from the sympathetic to the parasympat Learn more about your ad choices. Visit megaphone.fm/adchoices

What supplements should you be taking? We chat about our daily regimen, and continue our conversation about the enneagram, taking a deeper dive into type 5. We chat with Kelley Nikondeha, author of Adopted: The Sacrament of Belonging in a Fractured World, about some of the unique strengths and challenges of being an enneagram 5, as well as with Seth Haines, author of Coming Clean, about some of the internal fears and motivations unique to type 5's. We also share a great offer from Grove Collaborative, our favorite destination for clean and nontoxic beauty and cleaning products. They are offering new customers the following as a gift with purchase this week only; Mrs. Meyer's hand soap Mrs. Meyer's dish soap Mrs. Meyer's hand lotion Grove Collaborative cleaning caddy Grove Collaborative walnut scrubber sponges Use this link to cash in on this offer! Here are some of the supplements we talk about in this episode: SmartyPants chewable gummies ($14 for a month supply on Amazon( Vitamin D Alpha Lipoeic Acid Methylated Folate (a form of folic acid that is safe for everyone) Probiotics Omega 3 Fish Oil (burpless!) or DHA Omega 3 gummies Natural Calm Magnesium Riboflavin (B2)

In 10 years, the omega-3 market has grown from a concentration on fish oil concentrates to a diverse industry with several sources and an increasingly interesting scientific substantiation. Adam Ismail, Global Organization for Eicosapentaenoic Acid (EPA) and docosahexaenoic acid (DHA) Omega-3s (GOED), described these factors and more that have matured the omega-3 industry in the past decade. In this podcast with Sandy Almendarez, editor in chief, INSIDER, Ismail discuses: • The increase of quality omega-3 products on the market, spurred by a commitment to the GOED monograph, which is stricter than any regulation • How research—good and bad—have affected consumer interest in omega-3s, and emerging research that shows omega-3s’ benefit to health conditions beyond heart health • The growing number of sources for long-chain polyunsaturated acids (PUFAs), and how they help sustainability and a brand’s point of differentiation. Learn more about the issues and controversies affecting the omega-3 market at the GOED Exchange, Feb 6 to 8 in Seattle. Read more about Ismail’s take on the past decade in the INSIDER article, “10 Years of Fish Business.”

“I honestly believe this is a public health concern, particularly for those at risk for heart-related conditions” – Ellen Schutt  Ellen Schutt is the Communications Director with GOED, the Global Organization for EPA and DHA Omega-3s. GOED is an omega-3 trade association that works to educate about the importance of marine omega-3s. Most Americans (95%) do not get enough omega-3s and may not even be aware they aren’t getting enough. Omega-3s are important for many different reasons: heart health, brain health, eye health, and prenatal and maternal health. In this episode, we discuss the health benefits and the various options to increase omega-3 intake.  For the full show notes go to www.soundbitesrd.com.

Today’s Podcast is on PTSD Post Traumatic Stress Disorder. PTSD was first added to the third edition of the Diagnostic and Statistical Manual of Mental Disorders in 1980 by the American Psychiatric Association. When I first heard the term PTSD in the 80’s and 90’s it was something that I thought was tied to veterans coming back from war. Now when I hear about someone suffering from PTSD I recognize it as a someone who has experienced trauma in some way. Could be a car accident, a sexual assault, a mugging or in the case of today’s guest, a bike accident. Today’s guest is David Field. Before becoming a Trauma Therapist in training he worked with artists that included Radiohead, Crowded House and Carly Simon. After a traumatic bicycle accident in California, David spent years in pain and rehabilitation and suffered from depression and PTSD. Last year he made a life changing decision to go back to school and become a trauma therapist.   DAVID’S BOOK RECOMMENDATION:  Peter Levine: In an Unspoken Voice: How the Body Releases Trauma and Restores Goodness   SHOW NOTES ON PTSD RELATING TO BRAIN TRAUMA: PQQ - pyrroloquinoline quinone - discovered about 50 years ago, PQQ is currently being researched for its role in healing the brain. PQQ has been found to increase the formation of new nerve cells. PQQ can promote growth of new mitochondria and improve the function of existing mitochondria. PQQ has been shown to help protect the brain from neurodegenerative diseases and the effects of traumatic brain injury, including damage from stroke.   Mitochondria - Mitochondria are rod-shaped organelles that generate power for a cell. Responsible for aerobic cellular respiration, the process of converting oxygen and nutrients into adenosine triphosphate (ATP), the chemical energy that powers the cell's metabolic activities.  Mitochondria divide independently of the cell in which they reside, meaning mitochondrial replication is not dependent on cellular division.    Healthy Fats - It's easy to understand the importance of omega 3's and phospholipids when one realizes that the human brain and nervous system are made up of approximately 60% fat (mostly DHA - an omega 3 fatty acid).   Omega 3 Fatty Acids Support inflammation response Support mood and cognitive function Brain and nervous system mostly DHA Omega 3 protocol used for brain injury   Phospholipids - fats needed to build brain cell membranes that are fluid enough to release the neurotransmitters
 phosphatidylserine - required by the brain to manufacture memory-related neurotransmitters and functional membrane lipids, one of the few things shown to reverse age-related memory loss in clinical studies. phosphatidylcholine - required by the brain to manufacture memory-related neurotransmitters and functional membrane lipids. Essential nutrient necessary for normal brain function and the most abundant phospholipid found in the body. It’s found in its highest concentration in the liver and brain. alpha-glycerylphosphorylcholine (Alpha GPC) - Required by the brain to manufacture memory-related neurotransmitters and functional membrane lipids it’s believed to support cognitive function in high doses.   Lion's Mane - powerful medicinal mushroom and nerve tonic that benefits the brain and nervous system. Lion's Mane has been used successfully if Japan with patients with mild cognitive impairments. Lion's Mane is believed to have nerve-regenerative properties. Lion's Mane contains at least two classes of Nerve Growth Factors (NGFs)    Bacopa Monnieri - a powerful adaptogen commonly used in Ayurvedic medicine that is believed to support brain health, memory, and cognitive function.   Has been used for centuries for memory support and to cope with stress. Research has found the compounds in Bacopa to support the brain cells that prompt the regeneration of brain tissue.   Curcumin - the extract of Turmeric that supports the bodies inflammation response when used properly. Is currently being used to treat central nervous system injury,inflammation, and specifically for traumatic brain injury. Nervines - herbs that are of general benefit to the nervous system, whether they be tonifying or simply help to calm the nerves. Oatstraw Chamomile Lemon Balm Motherwort Lion's Mane - really more of a long-run tonic.  The best results come in time with this one.  Adaptogens - herbs or compounds considered to be safe that improve the bodies resiliency in dealing with physical, emotional, or environmental stress.   Cordyceps Ashwagandha Rhodiola Rosea Asian Ginseng American Ginseng  Moomiyo (Shilajiit)