Podcasts about sh2

The Government has announced the reversal of speed limit reductions on a large number of New Zealand roads, including many in the northern regions of the country. The move will result in speed limits being increased on 38 sections of key routes, including parts of State Highway 1 in Northland, SH16 near Auckland and SH3 in Hamilton. Also on the list are changes to SH2 between Featherston and Masterton, and SH3 Whanganui. Making the announcement in Wairarapa, where the speed limit increase will save drivers around three minutes on their journey, Transport Minister Chris Bishop said: “It all adds up - that is productivity and growth.” Viastrada Certified Safe System Assessor and Level Crossing Safety Impact Assessor Glenn Koorey says the move goes against evidence that lower speeds make for safer roads, but there are some areas where putting the limit up can be justified. LISTEN ABOVESee omnystudio.com/listener for privacy information.

Nebel verhüllt die aufgerissenen Straßen, das Radio fängt laut an zu Kratzen, Sirenen in der Ferne... diese Stichworte reichen aus, um Videospiel- und Horrorfans schnell klarzumachen, von was hier die Rede ist.Konami hat es nach über einem Jahrzehnt doch mal wieder geschafft, ihrer längst totgesagten Horrormarke Silent Hill neues Leben einzuhauchen und remaked ausgerechnet den ikonischsten Teil des gesamten Franchises. Ob das gut ausgegangen ist und wie Max generell so seit 1999 zu der verschneiten Kleinstadt steht, verrät er euch in der 143. Ausgabe der Mancave.Der Interprationsansatz sowie Spoilerteil zu SH2 am Ende sind klar im Podcast gekennzeichnet, so wird euch nicht zu viel verraten, wenn ihr nicht so viel wissen wollt. //WERBEPARTNER „HOLY“Gönnt euch den Nukular Shaker! https://www.radionukular.de/holyErstbesteller welcome! Spart 5€ mit dem Code "NUKULAR" auf die erste Bestellung oder gönnt euch für jede weitere Order 10% mit dem Code "NUKULAR10" - Das sind Freunde von uns, also geniesst die Sache nochmal ein besonderes Prädikat. Alle Produkte kommen ohne Zucker oder Taurin aus. Gutes Ding!//PATREONSondercontent, Early Access, Discord und Support von Maxe?Dann flott auf www.patreon.com/diemancave///TWITCH & YOUTUBEMaxi auf Twitch sehen könnt ihr auf twitch.tv/nerdyterdytimeDie Highlights gibts auf youtube.com/@nerdyterdytime///MEIN SHOPEin kleiner liebevoller Onlinestore für Toys, Sammelbares und Klamotten ist nerdyterdygang.de Hosted on Acast. See acast.com/privacy for more information.

咱當時會當同齊看著 烏洞、鬱金香、kah 天鵝？暗暝 ê 時陣，若是時間有拄好，而且你 ê 望遠鏡有指向 正確 ê 方向，按呢就看會著！這个複雜 美麗 ê 鬱金香星雲 就 tī 天鵝座 方向 8000 光年遠 ê 所在。Tī 天鵝座邊仔 ê OB3 星協 內底有 O 型星 HDE 227018。這款少年高能 ê 恆星發出 紫外光輻射，kā 鬱金香星雲內底 ê 原子 離子化，產生發射線。天文學家 Stewart Sharpless tī 1959 年 編 ê 目錄 內底，kā 這陣 70 光年長 ê 星際氣體 kah 塗粉 叫做 Sh2-101。這个視野 內底閣有 一粒烏洞 天鵝座 X-1。伊其實是一粒 微類星體，是天頂上強 ê X-光 發射源 之一。Tī 這个宇宙鬱金香花葉 ê 正爿，咱會當看著較暗較藍 ê 衝擊波前，彼是 ùi 藏 tī 星雲 內底 ê 烏洞 噴出來 ê 強力噴射流 驅動--ê。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20240828/ 影像：Anirudh Shastry 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap240828.html Powered by Firstory Hosting

Alguns destaques do Jornal da Manhã dessa segunda-feira (02): Primeira turma do Supremo Tribunal Federal começa a julgar se mantém ou não a decisão de Alexandre de Moraes que suspendeu o “X” do Brasil. A análise começou a 0h de hoje no plenário virtual. Os ministros Cármen Lúcia, Luiz Fux, Cristiano Zanin e Flávio Dino, tem até o final da noite para apresentar o voto. Elon Musk expõe determinação sigilosa de Moraes que levou ao bloqueio do “X” por descumprimento em perfil identificado como ‘Alexandre Files'. A plataforma revela a determinação do ministro para suspender usuários envolvidos em campanha de intimidação e ameaças a policiais federais que investigam atos antidemocráticos e milícias digitais. Starlink diz a presidente da Anatel que não vai cumprir determinação de Alexandre de Moraes de impedir acesso de clientes ao “X”. Segundo Carlos Baigorri, a provedora de internet por satélite, que também pertence a Elon Musk, informou que não pretende acatar a ordem enquanto o ministro não liberar as contas bancárias da empresa. Arthur Lira adia anúncio de candidato para a sucessão dele na presidência da Câmara e debate tema com Jair Bolsonaro. O parlamentar havia estabelecido agosto como mês em que indicaria o nome que pretende apoiar, mas o prazo se esgotou no final de semana sem que ele fizesse a escolha. Governo revoga licitação de R$ 200 milhões da Secretaria de Comunicação Social da Presidência, após suspensão pelo Tribunal de Contas da União por suspeita de irregularidade. Em publicação no Diário Oficial da União, a SECOM diz que desfez o processo por motivo de conveniência e oportunidade e abriu prazo de três dias para as empresas vencedoras entrarem com recurso. Debate da TV Gazeta e MyNews, em São Paulo, é marcado por trocas de acusações e de ofensas entre candidatos à prefeitura. Principal alvo, Pablo Marçal, do PRTB, foi confrontado por Guilherme Boulos, do PSOL, e Ricardo Nunes, do MDB, que dividem a liderança com ele, mas também foi assunto nas falas de José Luiz Datena, do PSDB e Tabata Amaral, do PSB. Rússia afirma ter interceptado mais de 150 drones em maior ataque ucraniano ao país, inclusive em Moscou. Aeronaves atingiram refinaria de petróleo na capital e usina elétrica de Konakovo, na Ucrânia. 44 pessoas ficaram feridas após mísseis russos atingirem prédios residenciais, um shopping center e uma instalação esportiva em Kharkiv. Israel tem noite de protestos após encontro de corpos de 6 reféns em Gaza. Manifestantes tomaram as ruas de Tel Aviv e outras cidades para pedir a saída de Benjamin Netanyahu, acusado de se recusar a fechar acordo de cessar-fogo que traria de volta os que estão em poder do Hamas. Estados Unidos darão ultimato a Israel e Hamas em nova proposta de cessar-fogo. Segundo o jornal The Washington Post, oficial do governo americano afirmou que a Casa Branca pode abandonar o papel de mediador nas negociações de trégua em Gaza, caso não haja acordo na atual rodada de tratativas. Agências da ONU iniciam vacinação contra a poliomielite na Faixa de Gaza. A imunização que pretende atingir cerca de 640 mil crianças começou ontem na região central do enclave, após Israel concordar com pausas limitadas nos combates. Em Paris, Brasil conquista medalha de número 400 em Jogos Paralímpicos em dia sem nenhum ouro. A marca histórica foi atingida com bronze do paulista André Rocha no lançamento de disco, classe F52, após outros dois bronzes na natação e uma prata inédita no tiro esportivo, modalidade SH2.    Essas notícias e muito mais você confere nessa edição do Jornal da Manhã. Learn more about your ad choices. Visit megaphone.fm/adchoices

00:00:00 - Kezdés 00:15:00 - PB0: Senki sem akar Xboxot 00:27:05 - Új IP-n dolgozik a Sony Santa Monica 00:31:25 - Ne izéljetek má', jó lesz a SH2 remake 00:39:40 - Új játékon dolgozik a Larian 00:50:15 - Már "senki" sem játszik a Hellblade 2-n 01:08:20 - Petíció a régi játékok megmentéséért 01:32:40 - Február 18-ra csúszik az Avowed 01:37:10 - Szarban a Warner, kalapács alatt a gaming szárny? 01:44:38 - 2x erősebb lesz a PS5 Pro, mint a PS5 01:59:20 - Xbox jövőkép: handheld és ingyenes multi? 02:06:25 - Jön a For Honor 2? 02:10:25 - PS5: tízből nyolc játékot digitálisan veszünk 02:16:28 - Szart se termelnek a Square SP játékai 02:23:07 - Steam: mindenki lesz*rja a 4K-t 02:27:23 - Sony: A PSVR2 eleve pécére is készült - kamu! 02:31:55 - Arany a Wukong 02:34:24 - Megvette a Ubi az Outlook kritikákat? 02:45:45 - Bezár a Ready at Dawn 02:46:30 - Jön a Jedi: Survivor prevgenre

地球 ê 花枝無遮爾大隻啦！這个星雲是一隻神祕 ê 花枝形宇宙雲，伊 tī 天頂足暗、嘛足大–ê。這幅圖 是 kā 30 點鐘久 ê 狹頻影像資料組合出來–ê，大細差不多是 3 粒 月娘 遐爾闊，就 tī 皇家星座 仙王座 遐。大花枝星雲是法國 ê 天文攝影師 Nicolas Outters tī 2011 年發現–ê。這是 伊發現 ê 第四个天體，所以才會號做 Ou4。伊 ê 雙極結構 有夠清楚，是雙電離酸素原子 發出 ê 青藍色 發射線。因為大花枝星雲去予紅色 ê 水素 發射線區 包 tī 內底，所以伊真正 ê 距離 kah 特性才會 遮爾歹量。最近 ê 研究 認為講，Ou4 應該是 tī 發射星雲 Sh2-129 內底，差不多是 2300 光年遠。照這个推論，這隻宇宙大花枝可能是一个壯觀 ê 噴流，是 ùi 星雲中心彼个高溫、大質量 ê 三星系統 HR8119 噴出來–ê。若真正是按呢，這隻實在有夠大隻 ê 花枝星雲，應該是比 50 光年 閣較長。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20240617/ 影像：Alex Linde 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap240617.html Powered by Firstory Hosting

是毋是獅仔星雲才是 仙王座 內底上大--ê？這个看起來敢若是一隻貓仔科動物 ê 星雲，是 2 粒 20 倍以上 太陽 質量 ê 大質量恆星 咧提供能量。星雲是 離子氣體殼 湠出來--ê 結構，伊 ê 高能物質毋但會 發光，密度嘛懸甲產生 重力收縮，形成新 ê 恆星。獅仔 星雲 ê 官方名稱是 Sh2-132，伊 ê 角寸尺比 規粒月娘 較大一屑屑仔。這个 有特別外形 ê 氣體區 差不多是 tī 1 萬 光年 遠 ê 所在。伊就 tī 仙王座內底，這是一个用 希臘神話 Aethopia 國王 ê 名 號名 ê 星座。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20240610/ 影像：Imran Badr 文稿：Natalia Lewandowska (SUNY Oswego) 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap240610.html Powered by Firstory Hosting

Join Msgr. John Esseff as he introduces us to the Enthronement of the Sacred Heart and of its incredible importance. The post SH2 – Introduction to the Sacred Heart, Continued – Building a Kingdom of Love with Msgr. John Esseff – Discerning Hearts Podcast appeared first on Discerning Hearts Catholic Podcasts.

Thank goodness for gameplay-less game trailers or I'd never get through them all! No timestamps this week as I spend the entire episode talking about the various video game trailers that caught my eye. If you missed Saturday's live broadcast of Molehill Mountain, you can watch the video replay on YouTube.  Alternatively, you can catch audio versions of the show on iTunes. Molehill Mountain streams live at 7p PST every Saturday night! Credits: Molehill Mountain is hosted by Andrew Eisen.  Music in the show includes “Albino” by Brian Boyko. It is in the public domain and free to use. Molehill Mountain logo by Scott Hepting. Chat Transcript: 7:01 PMJared Knisely​​video with stupid humor 7:01 PMSheekago​​Hey Adrew 7:01 PMJared Knisely​​i did watch that 7:02 PMOriana​​Hey, what day do you upload the reaction to The Code? 7:03 PMOriana​​wait, your beard grew... 

這个宇宙氣波去予大質量恆星 ê 高溫、高速恆星風吹 kah 遮爾大。伊去予編做 Sharpless 2-308，tī 大隻狗（大犬座）方向 5000 光年遠 ê 所在，比一粒月娘 tī 天頂 ê 寸尺閣較闊。按照這个距離來推算，這个直徑 差不多是 60 光年長。產生這个氣波 ê 大質量恆星是 Wolf-Rayet 星，to̍h 是星雲 中央附近 上光彼粒。Wolf-Rayet 星 ê 質量比太陽閣跤大 20 倍，伊應該是大質量恆星演化過程中，變做超新星進前 一个較短 ê 階段。Wolf-Rayet 星 ê 高速恆星風 tī 演化早期，會掃過行較慢 ê 物質，製造氣波形體 ê 星雲。這个 去予風歕出來 ê 星雲差不多有 7 萬歲 矣。這幅 深空影像 ê 狹頻濾鏡有翕著較暗 ê 發射線。影像內底上主要 ê 部份是發光 ê 離子化 酸素原子，tī 遮 kā 標做 藍色 ê。SH2-308 看起來 真古錐 ，伊嘛叫做海豬仔頭星雲。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20240607/ 影像：Prabhu Kutti 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap240607.html Powered by Firstory Hosting

這規片發光氣體塗粉雲，對 地球 ê 天文學家來講，看起來敢若是一隻鳥仔，所以伊才會提著這个外號，海鷗星雲。這隻 宇宙鳥仔 ê 肖像 包括了銀河盤，闊度有 2.5 度，就 tī 天狼星 方向附近。天狼星 是 大犬座（大隻狗星座）ê alpha 星。是講，這區 嘛有其他目錄 ê 天體，像有名 ê NGC 2327，伊是一个實密、厚塗粉 ê 發射星雲 kah 反射星雲，內底有一粒大質量恆星，這部份就是 海鷗 ê 頭。這規片海鷗星雲去予編做 Sh2-296 抑是 IC 2177，應該是連紲 ê 超新星爆炸 產生幾若重 大型外殼結構 ê 一部份。Tī 中央正爿下跤 彼个顯目 ê 藍色光弧，是 ùi 大犬座 FN 星 噴出來 ê 弓形衝擊波。這个複雜 ê 氣體塗粉雲主要是成份是發紅光 ê 水素原子。伊 kah 大犬座 ê OB1 星協 tī 天頂佔 200 光年闊，就 tī 離咱 3800 光年遠 ê 海鷗星雲 遐。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20240313/ 影像：Gianni Lacroce 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap240313.html Powered by Firstory Hosting

Kenyan doctors have vowed to continue their 23-day-old strike to demand better pay and improved working conditions. This, after a labor court in Nairobi Wednesday ordered the doctors to suspend the strike and complete negotiations with the government within 14 days. The doctors say the government has failed to implement a collective bargaining agreement signed in 2017. The government has accused the doctors of refusing to compromise. On Wednesday, the government offered to make available Sh2.4 billion (a little over $184 million) to cover the deployment of interns or junior doctors. Meanwhile, the strike has paralyzed health services at some hospitals. Dr Simon Kigondu, President of the Kenya Medical Association, tells VOA's James Butty, the strike will continue until the government completely addresses of all their concerns.

TCW Podcast Episode 206 - SEGA Saturn Part 1   In this in-depth exploration of the SEGA Saturn, our focus delves into the intricate technology that underpins the console. We delve into the challenges associated with 3D modeling, collision detection, and object occlusion, scrutinizing how the Saturn, primarily a sprite-based system, manages to incorporate 3D elements. The pivotal moment arrives with the announcement of the Sony PlayStation, prompting SEGA's aspirations for enhanced 3D capabilities. SEGA sought Hitachi's involvement to augment the machine's speed for handling 3D demands. Fortuitously, the utilization of the SH2 chip presented an opportunity for two processors to collaborate seamlessly. Our discussion delves into the profound technical intricacies, laying the groundwork for the subsequent episode where we will unravel the repercussions of these technological endeavors for SEGA and the Saturn.   TCW 127 - Dreams of SEGA: http://podcast.theycreateworlds.com/e/dreams-of-sega/ TCW 129 - The Crash That Almost Was: http://podcast.theycreateworlds.com/e/the-crash-that-almost-was/ Workstation VS Desktop: https://www.youtube.com/watch?v=KpBWaiWcXAk Workstation VS Gaming PCs: https://www.youtube.com/watch?v=IMSx2MUHSWM The Abyss - CGI Making of 1989: https://www.youtube.com/watch?v=gAFIUuFRkBA Terminator 2 Advanced Photorealistic Morphing: https://www.youtube.com/watch?v=37YrnLbQda0 How Did They Get the CGI in Jurassic Park to Look so Good?: https://www.youtube.com/watch?v=l4UuQxjFpfU TCW 087 - Virtual History: http://podcast.theycreateworlds.com/e/virtual-history/ Z-Buffer - Friday Minis: https://www.youtube.com/watch?v=F9GyYKcLDaw How Games Have Worked for 30 Years to Do Less Work: https://www.youtube.com/watch?v=CHYxjpYep_M Doom Engine - Limited but still 3D: https://www.youtube.com/watch?v=ZYGJQqhMN1U Collision Detection in Quake: https://www.youtube.com/watch?v=wLHXn8IlAiA MDShock: https://mdshock.com/ RISC vs CISK: https://www.youtube.com/watch?v=6Rxade2nEjk Universal Logic Gates: https://www.youtube.com/watch?v=jPLg_P9dHNY Rodrigo Copetti Technical Breakdown Website https://www.copetti.org/ SEGA Saturn Architecture: https://www.copetti.org/writings/consoles/sega-saturn/ SEGA Saturn Polygon Distorted Sprite Demo: https://www.youtube.com/watch?v=8TleepxIORU Why Was the SEGA Saturn so Hard to Develop On: https://www.youtube.com/watch?v=oa5pIfDvd68 Why Triangulate Game Assets: https://www.youtube.com/watch?v=6oY_Ogj9Gh0   New episodes are on the 1st and 15th of every month!   TCW Email: feedback@theycreateworlds.com  Twitter: @tcwpodcast Patreon: https://www.patreon.com/theycreateworlds Alex's Video Game History Blog: http://videogamehistorian.wordpress.com Alex's book, published Dec 2019, is available at CRC Press and at major on-line retailers: http://bit.ly/TCWBOOK1     Intro Music: Josh Woodward - Airplane Mode -  Music - "Airplane Mode" by Josh Woodward. Free download: http://joshwoodward.com/song/AirplaneMode  Outro Music: RolemMusic - Bacterial Love: http://freemusicarchive.org/music/Rolemusic/Pop_Singles_Compilation_2014/01_rolemusic_-_bacterial_love    Copyright: Attribution: http://creativecommons.org/licenses/by/4.0/

Jeżeli chcesz docenić moją twórczość - postaw mi kawę! https://buycoffee.to/okiemdeva Zacznij wspierać ten kanał, a dostaniesz te bonusy na YouTube: https://www.youtube.com/channel/UCiIpsRTb_RDda9w3WL7fndA/join oraz Spotify: https://podcasters.spotify.com/pod/show/okiemdeva/subscribe Niecodziennik 2024.01.08 00:00:00 Intro 00:00:23 Nowy rok, nowe zwolnienia 00:01:36 Rekordowo drogie DLC 00:03:33 Pomoc przy Outer Worlds 2 00:05:30 SH2 i MGS3 potwierdzone na 2024 00:06:23 Były co-dev Redfall planuje nowy tytuł 00:08:29 Ile są warte gry w XGP? 00:11:21 Mobilne PC od MSI 00:13:40 Nowy Switch: Ewolucja czy Rewolucja? 00:16:26 CD Projekt RED nie do kupienia 00:20:33 REKORDOWY rok dla Steam 00:26:31 Outro https://insider-gaming.com/bossa-studios-layoffs-lost-skies/ https://www.gamesindustry.biz/vr-game-studio-archiact-announces-layoffs https://www.gamesindustry.biz/stray-souls-developer-jukai-studio-announces-closure https://www.gamedeveloper.com/business/report-3d-realms-and-slipgate-may-have-been-hit-with-more-layoffs https://www.vg247.com/star-citizen-46k-ship-dlc-pack https://www.vg247.com/outer-worlds-2-devs-help-from-fallout-creator https://www.videogameschronicle.com/news/metal-gear-solid-delta-and-silent-hill-2-will-release-this-year-according-to-playstation/ https://insider-gaming.com/redfall-collaborator-studio-gobo-planning-new-aaa-game/ https://www.vg247.com/xbox-game-pass-2023-new-games-did-you-play-enough https://videocardz.com/newz/msi-claw-gaming-handheld-leaked-features-intel-core-ultra-7-155h-with-arc-graphics-and-32gb-memory https://insider-gaming.com/new-nintendo-switch-might-be-a-switch-pro-rather-than-a-switch-2/ https://www.gamesindustry.biz/cd-projekt-red-uninterested-in-being-acquired https://www.videogameschronicle.com/news/a-record-14000-games-were-released-on-steam-in-2023/ Music from #Uppbeat (free for Creators!): https://uppbeat.io/t/kidcut/desert-druids License code: TWVG0Z7J2RRKBOND Wspierający Junior Dev: Kojo Bojo, bibru RG, Exit Wound, ZajacccXD, CHRZ, Mithrandir, Ania Węglarzy, MichalDev, FiSherMan414, Aliwera, Lukas P Regular Dev: PabloRal, Bonga, Aquatofana, Leniwa Ola, Anatae GG, Sebastian Sadowy Senior Dev: Pielgrzym, Dawid Kuc, Morfiniusz Buycoffe.to: Mateusz Śliwakowski, Tomek Mar, Magdalena Kmieciak Mój nowy kanał po angielsku: @WaywardPreacher https://www.youtube.com/@WaywardPreacher Pog(R)adajmy https://www.facebook.com/pogradajmy Piekło produkcyjne w grach https://youtu.be/_5F_0ikkS5E Ile kosztuje tworzenie gier? https://youtu.be/hOOshkT15cI Okiem Deva to kącik w sieci, w którym z perspektywy twórcy gier będę omawiał sprawy związane z grami i gamedevem. Subskrybuj mój kanał lub zapisz się do newslettera, a będziesz na bieżąco z najnowszymi informacjami i spostrzeżeniami na gry z mojego punktu widzenia. WWW: https://okiemdeva.pl Facebook: https://www.facebook.com/okiemgamedeva Twitter: https://twitter.com/OkiemDeva Medium: https://okiemdeva.medium.com/ Beehiiv: https://okiemdeva.beehiiv.com/ Spotify: https://sptfy.com/OkiemDeva Instagram: https://www.instagram.com/okiemdeva/ Snapchat: https://www.snapchat.com/add/okiemdeva TikTok: https://tiktok.com/@okiemdeva RSS: https://anchor.fm/s/7bc4d6c0/podcast/rss YouTube: https://www.youtube.com/c/OkiemDeva --- Send in a voice message: https://podcasters.spotify.com/pod/show/okiemdeva/message

這隻 燕魟 tī 宇宙海內底 leh 飛。這个烏暗星雲 ê 正式編號是 SH2-63 抑是 LBN 86，是氣體 kah 塗粉組成--ê，伊 ê 外形就親像是 海底 ê 魚仔。這个 星際塗粉 星雲 ê 光是咖啡色--ê，因為伊 kā 伊後壁 ê 可見光 閘 leh、予光 變較紅。烏暗星雲主要是 tī 紅外線 leh 發光，毋過伊嘛會 tī 可見光 反射伊邊仔 ê 恆星光。烏暗星雲內底 ê 塗粉粒，一般攏是 tī 次毫米波看會著 ê 炭素、sir-lí-khóng、酸素，in ê 表面定定有 堅一重 一酸化炭素 kah 窒素。烏暗星雲嘛是 分子雲，因為

恆星形成區就親像是一支宇宙筅仔，利用內底 ê 發射線、塗粉、kah 烏暗星雲畫圖，畫出一張 星際畫布。這是一張 5 度闊 ê 望遠鏡拼鬥圖，這區包括 足光 ê 畢宿五以北 ê 區域，就 tī 金牛座分子雲 氣泡 ê 內底壁。相片倒爿下跤有 編號 Sh2-239 ê 發射線，可能是少年恆星藏 tī 遐。這區 ê Herbig-Haro 天體 (HH 天體)，是 kah 拄生出來 ê 恆星有關 ê 星雲，伊 ê 特徵是水素氣體受著衝擊產生 ê 紅色噴射流。金牛座 T 星 ê 正爿頂懸，是 金牛座 T 型變星 ê 原形。伊 ê 邊仔是一个黃色星雲，歷史上 kā 叫做 Hind 變光星雲 (NGC 1555)。金牛座 T 星這馬去 hŏng 認為是一粒少年、猶無夠幾若百萬歲 ê 類太陽恆星，猶 tī lih 恆星形成 ê 早期階段。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20231123/ 影像：Yuexiao Shen, Joe Hua 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap231123.html Powered by Firstory Hosting

這幅星際星場內底 ê 恆星 kah 塗粉，敢有啥物形體予你感覺足趣味--ê？這規片闊莽莽、反射恆星光 ê 雲，就敢若是有 寶石 tī 內底仝款，伊就浮 tī 皇家星座 仙王座 ê 夜空。這寡 敢若幻影 ê 幽靈 離 地球 厝邊隔壁猶足遠--ê，in 就 tī 銀河盤內底，仙王座爍光 分子雲複合體 ê 邊緣，離咱有 1200 光年 遠。Tī 這幅圖 下底 ê 幽靈星雲，編號是 VdB 141 抑是 Sh2-136。伊有超過 2 光年大，是比其他 奇奇怪怪 ê 組合體 較光。反射星雲 內底閣看會著 早期 恆星形成過程中，實密核心 崩塌 ê 明確痕跡。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20231030/ 影像：Bogdan Jarzyna 音樂：P!SCO - 鼎鼎 聲優：阿綠 翻譯：An-Li Tsai (NSYSU) 原文：https://apod.nasa.gov/apod/ap231030.html Powered by Firstory Hosting

Today on the panel Alison Mau and Liam Hehir find out what's behind the shambles at Auckland Airport, and what needs to be done to fix up SH2 with ongoing closures and disruptions. And, do sleep trackers help or hinder?

BUFFALO, NY- November 8, 2023 – A new editorial #paper was #published in Oncotarget's Volume 14 on March 31, 2023, entitled, “Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors.” The SH2 domain-containing tyrosine phosphatase 2 (SHP2) is a ubiquitously expressed non-receptor protein tyrosine phosphatase, encoded by the PTPN11 gene. It is positively regulated by upstream receptor tyrosine kinases (RTKs) to activate downstream the RAS-ERK pathway. In this new editorial, researchers Giulia Franciosa and Jesper V. Olsen from the University of Copenhagen discuss potential leukemia therapies that effectively prevent adaptive resistance. Acute myeloid leukemia (AML) is a bone marrow malignancy characterized by a blockage of differentiation and an uncontrolled proliferation of myeloid hematopoietic progenitor cells. The internal tandem duplication (ITD) in the juxtamembrane domain of the RTK FLT3 is an oncogenic driver mutation that leads to constitutive activation of its tyrosine kinase activity. Consequently, FLT3 inhibitors that block its tyrosine kinase activity represent the targeted treatment option for patients with FLT3-ITD AML, often administrated in combination with induction chemotherapy. “Nevertheless, the short duration of remission urges the development of novel combinatorial therapies for FLT3-ITD AML.” Since 2016, several potent and selective allosteric, noncovalent SHP2 inhibitors have been developed and tested in clinical trials for solid tumors. A recent study reported the effectiveness of short-term treatment with the allosteric SHP2 inhibitor SHP099 as a single agent in clinically relevant mouse models of Flt3-ITD AML. This observation was in contrast with published data showing that allosteric SHP2 inhibition is only effective as combination treatment with inhibitors of other nodes of the RAS-ERK pathway. In a research article published by Pfeiffer et al., the Olsen's lab at University of Copenhagen showed that two commercial FLT3-ITDpositive AML cell lines (MV-4-11 and MOLM-13) developed adaptive resistance after prolonged treatment in vitro with the allosteric SHP2 inhibitor SHP099. “All in all, the findings by Pfeiffer et al. suggest that combined inhibition of SHP2 and mutated RTKs are effective in preventing adaptive resistance, but also highlight the need for development of more potent and effective SHP2 inhibitors and combination therapies for clinical applications.” DOI - https://doi.org/10.18632/oncotarget.28392 Correspondence to - Giulia Franciosa - giulia.franciosa@cpr.ku.dk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28392 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, SHP2, PTPN11, tyrosine, phosphorylation About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Tī 北方星座 仙王座 方向 12 度闊 ê 視野 內底，有星際氣體 kah 烏暗塗粉雲 相濫發光 ê 大片發射星雲 IC 1396 kah Sh2-129。相片倒爿彼个幾若百光年闊、3000 光年遠 ê 星雲，是 去予中央恆星 IC 1396 激發--ê。這个星雲有趣味 ê 烏暗形體，包括 tī 中央正爿下底 彼个 彎彎曲曲 ê 烏暗雲，象管星雲。伊有幾若十光年長，是恆星形成 ê 原始材料，咱這馬知影講 這內底有 原恆星。正爿 ê Sh2-129 chhāi tī 差不多遠 ê 距離，伊內底較光 ê 雲丸 kah 向後壁去--ê 發射雲脊，予伊提著 飛行夜婆星雲 這个名。最近才 tī 飛行夜婆星雲內底 揣著--ê，是 發出小可仔藍光 ê Ou4，大花枝星雲，拄仔好替 這个皇家宇宙動物園 添丁。相片正爿下底邊仔閣有 一个 因為 伊 ê 烏暗外形 才號名做 海馬星雲，伊 ê 編號是 Barnard 150。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20230817/ 影像：Yann Sainty 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap230817.html Powered by Firstory Hosting

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.551026v1?rss=1 Authors: Bashore, F. M., Katis, V. L., Du, Y., Sikdar, A., Wang, D., Bradshaw, W. J., Rygiel, K. A., Leisner, T. M., Chalk, R., Mishra, S., Williams, A. C., Gileadi, O., Brennan, P. E., Wiley, J. C., Gockley, J., Cary, G. A., Carter, G. W., Young, J. E., Pearce, K. H., Fu, H., the Emory-Sage-SGC TREAT-AD Center,, Axtman, A. D. Abstract: RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. FCER1G is a component of Fc receptor complexes that contain an immunoreceptor tyrosine-based activation motif (ITAM). SYK interacts with the Fc receptor by binding to doubly phosphorylated ITAM (p-ITAM) via its two tandem SH2 domains (SYK-tSH2). Interaction of the FCER1G p-ITAM with SYK-tSH2 enables SYK activation via phosphorylation. Since SYK activation is reported to exacerbate AD pathology, we hypothesized that disruption of this interaction would be beneficial for AD patients. Herein, we developed biochemical and biophysical assays to enable the discovery of small molecules that perturb the interaction between the FCER1G p-ITAM and SYK-tSH2. We identified two distinct chemotypes using a high-throughput screen (HTS) and orthogonally assessed their binding. Both chemotypes covalently modify SYK-tSH2 and inhibit its interaction with FCER1G p-ITAM. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Damaged highways are stopping produce getting to market, and forcing at least one freight company to add a surcharge to account for the major detours they have to take. State Highway Two between Gisborne and Opotiki will be closed until at least the end of the week, because of a drop out from more wild weather. Countdown has already told customers to be prepared for shortages of some vegetables. Further north in the Coromandel, another lifeline highway is out of action because of persistent slips. With the school holidays around the corner, they're already counting their losses. Krystal Gibbens has more.

Join Msgr. John Esseff as he introduces us to the Enthronement of the Sacred Heart and of its incredible importance. The post SH2 – Introduction to the Sacred Heart – Building a Kingdom of Love with Msgr. John Esseff appeared first on Discerning Hearts Catholic Podcasts.

Join Msgr. John Esseff as he introduces us to the Enthronement of the Sacred Heart and of its incredible importance. The post SH2 – Introduction to the Sacred Heart – Building a Kingdom of Love with Msgr. John Esseff appeared first on Discerning Hearts Catholic Podcasts.

Commuters are frustrated with heavy congestion on State Highway 2 between Ōmokoroa and Tauranga. The stretch of highway is used by more than 25-thousand vehicles a day and in recent weeks commuters have complained about huge delays. The Western Bay of Plenty District Council has been counting vehicles using side roads to skip the congestion. Councillor Don Thwaites told Heather du Plessis Allan the congestion is caused by the building of 800 metres of cycle track near Tauranga City. He said that the problem was a lack of roads, as there's only one crossing each for the Te Puna Stream and Wairoa River. LISTEN ABOVESee omnystudio.com/listener for privacy information.

South Wairarapa District Council is in an invidious position with the population expected to swell in the coming years, infrastructure is under the microscope, and Mary says the latest news is not good. Martinborough's wastewater treatment plant is at capacity. And while infrastructure is failing in some areas of the district, in others, such as Greytown, SWDC has publicly notified resource consents for large-scale developments including a 235-hectare solar farm project lodged by Far North Solar Farm. There's also been a new application lodged by Woolworths to build access to the local Fresh Choice supermarket from SH2. And Featherston was buzzing at the weekend with 8000 visitors drawn to the annual Booktown Festival.

是啥物星會當製造這个氣泡？毋是 氣泡正爿彼粒金爍爍 ê 星製造--ê。嘛毋是太空大 海豬 製造--ê。是藍色星雲中心彼粒，能量懸甲通人知 ê Wolf-Rayet 星 製造--ê。Wolf-Rayet 星 ê 質量一般講--來是超過 20 倍 太陽質量，伊會歕出速度足緊 ê 粒子風，做出這个 外形 足出名 ê 星雲。像這張影像內底這个恆星氣泡，大細是超過 60 光年闊，年歲有 7 萬歲矣，看起來敢若是海豬仔 ê 頭。伊 ê 編號是 Sh2-308，嘛叫做 海豬仔頭星雲。這粒氣體球離咱有 5000 光年遠，tī 天頂看--起來是 kah 規粒月娘 差不多大，是講伊較暗。這張 影像 倒爿紅色色調 ê 星雲，可能是 ùi 仝這粒 Wolf-Rayet 星 發射出來--ê 能量較懸 ê 輻射光 kā 激發、創出這个外形--ê。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20230329/ 影像：Aleix Roig (AstroCatInfo) 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap230329.html Powered by Firstory Hosting

When soldiers approach the supply sergeant expecting him to fulfill their list of needs, he responds with James 4:2, “You do not have because you do not ask.” SH2 #biblelessonsforkids, #prayer, #godanswersprayer, #askandyoushallreceive, #christiankids, #jesuschrist, #bedtimestoriesforkids, #storiesforchristiankids, #fishbytesforkids, #fishbytes4kids, #fishbitesforkids, #fishbites4kids, #ronandcarriewebb, #roncarriewebb

When soldiers approach the supply sergeant expecting him to fulfill their list of needs, he responds with James 4:2, “You do not have because you do not ask.” SH2 #biblelessonsforkids, #prayer, #godanswersprayer, #askandyoushallreceive, #christiankids, #jesuschrist, #bedtimestoriesforkids, #storiesforchristiankids, #fishbytesforkids, #fishbytes4kids, #fishbitesforkids, #fishbites4kids, #ronandcarriewebb, #roncarriewebb

Trucks are getting food, water and fuel to cut-off townships along SH2 between Ōpōtiki and Te Karaka. There are multiple hazards on the stretch of road, which is still closed to the public Steve Weatherall from Weatherell Transport offered up his trucks for the journey. He talks to Lisa Owen.

"The most significant weather event this century." That's the way Prime Minister Chris Hipkins has described the impact of ex-tropical cyclone Gabrielle. Communication and physical access to many communities, particularly in Hawke's Bay and Tairawhiti, remain difficult, with power outages adding to the strain. Hipkins said he is particularly concerned about Wairoa, where the Wairoa River has burst its banks, inundating 10-15 percent of the town which is home to around half of the town's 8000 population.  Communication was only partly restored late last night through the use of a Star Link terminal. Hawke's Bay Civil Defence said Wairoa has only one day's worth of food, and enough drinking water for two days. They have made a request to NEMA for enough food and water to supply the district for seven days. Travel between Napier and Hastings is not possible. SH2 is out due to flooding, with the Ngaruroro River Bridge closed due to flooding. SH51 is also closed due to severe weather conditions".  Further north, Wairoa is cut off as State Highway 2 Gisborne to Ōpōtiki and Napier to Gisborne is closed as is State Highway 35 Gisborne to Hicks Bay A Tokomaru Bay business owner said the highway through Tairāwhiti has sustained incredible damage.  Peter Cunningham of Highway 35 Cafe spent last night sheltering at an uphill marae along with most of the town's population.  He said Tokomaru Bay has been flooded - but Uawa/Tolaga Bay appears to be the worst-affected.  Gisborne residents are being asked to urgently conserve water after a break in the city's main supply, somewhere between the dams and the treatment plant.   The Government estimates roughly 2500 people have been displaced by Cyclone Gabrielle so far. This includes 1000 people in the Far North, 400 households in Auckland, 93 in Bay of Plenty, 75 in Waikato and roughly 1000 people in Hawke's Bay.  But with communication sparse, officials have struggled to get an idea of the damage caused throughout the country. Northland Civil Defence said hundreds of people were evacuated in Dargaville yesterday after the Awakino River burst its banks.   Further south, hundreds of people were rescued from raging flood waters in Hawke's Bay after rivers burst their banks. Hawkes Bay civil defence reported late last night that a woman in Putorino had died after a bank collapsed onto her home. Police visited the property following a missing person's report and undertook rescue efforts but were unsuccessful. And a body was found on the shore in Bay View, Napier shortly before eight-PM last night. It is not yet known if the death is connected to the flooding. Kevin McCormack spent most of the day on his roof with his wife and two neighbours after the Tutaekuri River in Napier burst its banks. In Muriwai, near Auckland, Fire and Emergency will resume the search today for the volunteer firefighter missing in a landslide. Dave van Zwananberg is a vet at Vets North in Kumeu. He is trapped in the wreckage of a house that collapsed. A person is in a critical condition in hospital after being hit by a a falling tree fell in a Kohimarama playground yesterday afternoon. AT's Executive General Manager of Safety, Stacey Van Der Putten said: "Aucklanders should be prepared for delays and disruption to travel today as flood damage, sea conditions, power outages and fallen trees continue to affect our roads and public transport network." Work is well underway to assess and repair damaged roads, with over 500 crew members working across Auckland. While dozens of roads have been reopened, there are currently more than 100 roads closed or partially closed. Many thousands of people still don't have power this morning and face extended outages. Power outages have been reported for 60,000 customers across Hastings, Havelock North, Napier, north along east coast to Tūtira and south to Waimārama. It is expected to take some time before power is fully restored across the region. At its peak earlier yesterday, across the country close to 225,000 people were without power, authorities said.  

The sun might be out but the job isn't done in the Coromandel, according to Coromandel-Thames Civil Defence controller Gary Towler. The region has experienced massive slips and land instability, compromising its entire roading network. ”Every time our land guys clear a slip, another one comes down right behind them,” Towler told Kerre Woodham Mornings on Newstalk ZB today. A number of houses in the Coromandel have already been red-stickered, Towler confirmed, as staff worked their way through affected areas to check the condition of housing. The other focus is power, which most of the area is still without. Powerco said it had 7462 customers without power in the Coromandel as of 8am today. ”We have the luxury of the New Zealand Defence Force, which we're deploying on to the east coast today to do a lot of review work and drone work to get a good picture of what carnage was created,” Towler said. Meanwhile, critical assets such as generators and wastewater plants in the Coromandel are running out of diesel, which helicopters are bringing in for stock-ups as they can't be accessed by road. If people are wanting to visit their homes and baches, Towler has told residents to “take a breath” and check the NZTA website and affiliated social media pages for information on road conditions. ”People need to have a go-bag and Plan B in case a slip blocks their path. That will be the case for the next five or six days,” he said. ”But people should check their properties as quickly as possible so we know if we're dealing with any other stretches. Coromandel road information STATE HIGHWAYS SH25 Thames to Coromandel Town is CLOSED. SH25 Coromandel Town to Te Rerenga: Essential travel only. Drive with extra care. SH25 Te Rerenga to Kūaotunu is CLOSED. SH25 Kūaotunu to Whitianga: Essential travel only. Drive with extra care. SH25 Whitianga to Tairua. SH25 Hikuai to Onemana is CLOSED. SH25 Whangamatā to Waihī: Essential travel only. Drive with extra care. SH2 Paeroa to Waihī (Karangahake Gorge) is CLOSED. SH26 between SH2 and Paeroa-Tauhuna Rd is CLOSED. SH25A Kopu to Hikuai is CLOSED. Waikawau Beach Rd is CLOSED due to tree fall. Purangi Rd is OPEN to one lane. Hikuai Settlement Rd is OPEN. Sailors Grave Rd is OPEN to one lane. Pumpkin Hill Rd is OPEN to one lane. Koputauaki Bridge, Colville Road – No further monitoring required. ONGOING CLOSURES Coromandel/Colville: Colville Rd is CLOSED in several places due to overslips and dropouts. Road will have to remain closed overnight. Coromandel to Oamaru Bay CLOSED. Oamaru Bay to Amodeo Bay CLOSED. Amodeo Bay to Colville CLOSED. Colville to Port Jackson Road CLOSED. Te Kouma Road is CLOSED due to a large tree/slip blocking the road. Road will have to remain closed overnight. Port Jackson Rd is CLOSED due to multiple very large slips and dropouts. Road will have to remain closed overnight. Port Charles Rd is CLOSED due to an overslip 10.7km from the start of the road. Road will have to remain closed overnight. Puriri Rd is CLOSED due to a treefall and large slip Road will have to remain closed overnight. 309 Road is OPEN. Mercury Bay: Hot Water Beach Rd is CLOSED Between SH 25 and Parangi Road due to flooding. Road will have to remain closed overnight. Matarangi Rd is CLOSED due to a large slip. A crew will establish today. Road will have to remain closed overnight. Whangapoua Rd is CLOSED due to a slip. Tairua-Pāuanui: Puketui Valley Rd is CLOSED due to a slip Road will have to remain closed overnight. Whangamatā: Wentworth Valley Rd is CLOSED due to flooding. Thames: Tapu Coroglen Rd is CLOSED and impassable for the foreseeable future. Location is 10km from Tapu. Additional slips have been cleared for resident access. Kauaeranga Valley Rd is CLOSED due to flooding and large slips Road will have to remain closed overnight. Victoria St, Thames is CLOSED due to flooding and a large slip Road will have to remain closed overnight. Other: Blackjack Road is closed to all traffic except those requiring residential access. An area of road subject to previous damage has suffered significant movement overnight, and while passable with care, should not be used unless access is needed. Council geotechnical staff will inspect the area as soon as possible. Hauraki state of emergency Meanwhile, Hauraki District Council has issued an update on Cyclone Gabrielle. Residents are being asked to conserve water. “Due to river conditions with high levels of dirt and debris, we are struggling to produce as much water as we would like in Paeroa and Waihi. Please conserve water. If you noticed a drop in pressure around Waitakaruru, the Water Treatment Plant is now back up and running.” The council says it is continuing to support the clean-up effort around the district and evaluating damage. It is compiling a list of affected properties and completing a welfare needs assessment. “Please call our team on 07 862 8609 or 0800 734 834. Our team will then pass the information onto our Civil Defence Welfare team.” Building inspectors will be out checking damaged properties today. They will have their council identification with them. “They are there to help, so please let them into your properties to do this important work.” “Please call us if your house has been inundated with flood waters and our team will create a service request so our teams know to visit.” Local roads: Road between Whiritoa and Waihi – OPEN drive with extreme caution Ford Road, Waihi – CLOSED due to flooding Baxter Road, Waihi – CLOSED due to flooding Komata Reef Road, Komata – CLOSED due to multiple slips Bradshaw Road Bridge, Komata – WATCH FOR surface flooding Franklin Road, Waitawheta - CLOSED under slip Maratoto Road Bridge – Assessment ongoing - tree down blocking upstream East Coast Rd north and south OPEN but surface flooding Miranda/Findlay Rd – OPEN Kaiaua Rd – OPEN with flooding in patches State Highways SH2 Karangahake Gorge CLOSED - Paeroa to Waihi SH26 Criterion Bridge OPEN SH25 Between Whiritoa and Whangamata OPENSee omnystudio.com/listener for privacy information.

這規片發光氣體塗粉雲，對 地球 ê 天文學家來講，看起來敢若是一隻鳥仔，所以伊才會提著這个外號，海鷗星雲。這張影像是 tī 天狼星 ê 方向附近，大犬座 α 星 遐。這張相片是 kā 3 張宇宙鳥仔 ê 狹頻影像資料疊出來 ê 拼鬥影像，攏總迒過銀河盤 2.5 度闊 ê 範圍。這規片海鷗星雲去予編做 Sh2-296 抑是 IC 2177，應該是連紲 ê 超新星爆炸 產生幾若重 大型外殼結構 ê 一部份。Tī 中央正爿下跤 彼个顯目 ê 藍色光弧，是 ùi 大犬座 FN 星 噴出來 ê 弓形衝擊波。大犬座 FN 星是一粒 對伊邊仔 ê 星際介質來講，離開速度足緊 ê 恆星。這个複雜 ê 氣體塗粉雲 kah 大犬座 ê OB1 星協 tī 天頂有 200 光年闊。In 就 tī 離咱 3800 光年遠 ê 海鷗星雲 遐。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20230119/ 影像：Carlos Taylor 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap230119.html Powered by Firstory Hosting

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.31.522383v1?rss=1 Authors: Matsubayashi, H. T., Mountain, J., Yao, T., Peterson, A. F., Deb Roy, A., Inoue, T. Abstract: Class IA phosphoinositide 3-kinase (PI3K) galvanizes fundamental cellular processes such as migration, proliferation, and differentiation. To enable multifaceted roles, the catalytic subunit p110 utilizes a multi-domain, regulatory subunit p85 through its inter SH2 domain (iSH2). In cell migration, their product PI(3,4,5)P3 generates locomotive activity. While non-catalytic roles are also implicated, underlying mechanisms and its relationship to PI(3,4,5)P3 signaling remain elusive. Here, we report that a disordered region of iSH2 contains previously uncharacterized AP-2 binding motifs which can trigger clathrin and dynamin-mediated endocytosis independent of PI3K catalytic activity. The AP-2 binding motif mutants of p85 aberrantly accumulate at focal adhesions and upregulate both velocity and persistency in fibroblast migration. We thus propose the dual functionality of PI3K in the control of cell motility, catalytic and non-catalytic, arising distinctly from juxtaposed regions within iSH2. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.20.521329v1?rss=1 Authors: Doggett, K., Keating, N., Dehkhoda, F., Bidgood, G. M., Leong, E., Kueh, A., Nicola, N. A., Kershaw, N. J., Babon, J. J., Alexander, W. S., Nicholson, S. E. Abstract: Suppressor Of Cytokine Signaling (SOCS) 1 is a critical negative regulator of cytokine signaling and required to protect against an excessive inflammatory response. Genetic deletion of Socs1 results in unrestrained cytokine signaling and neonatal lethality, characterised by an inflammatory immune infiltrate in multiple organs. Overexpression and structural studies have suggested that the SOCS1 kinase inhibitory region (KIR) and Src homology 2 (SH2) domain are important for interaction with and inhibition of the receptor-associated JAK1, JAK2 and Tyk2 tyrosine kinases, which initiate downstream signaling. To investigate the role of the KIR and SH2 domain in SOCS1 function, we independently mutated key conserved residues in each domain and analysed the impact on cytokine signaling, and the in vivo impact on SOCS1 function. Mutation of the SOCS1-KIR or SH2 domain had no impact on the integrity of the SOCS box complex, however, mutation within the phosphotyrosine binding pocket of the SOCS1-SH2 domain specifically disrupted SOCS1 interaction with phosphorylated JAK1. In contrast, mutation of the KIR did not affect the interaction with JAK1, but did prevent SOCS1 inhibition of JAK1 autophosphorylation. In human and mouse cell lines, both mutants impacted the ability of SOCS1 to restrain cytokine signaling, and crucially, Socs1-R105A and Socs1-F59A mice displayed a neonatal lethality and excessive inflammatory phenotype similar to SOCS1 null mice. This study defines a critical and non-redundant role for both the KIR and SH2 domain in endogenous SOCS1 function. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Talking about whatever you all want to talk about live and working on my second SH2 platinum. Apologies for the delay in shows, but thanks to everyone who showed up to talk live. Expect a more traditional episode of the podcast next week! Support the podcast: Patron.com/SMTN Subscribe on YouTube Here: https://www.youtube.com/user/torchwood4SP Check out the Shin Megami Tensei Network podcast on iTunes: https://podcasts.apple.com/us/podcast/shin-megami-tensei-network/id1527210478 Spotify: https://t.co/wOXqDqPqoc?amp=1 Find us online Twitter @SMTNetwork @Torchwood4sp Join the Facebook group: https://www.facebook.com/groups/SMTNetwork Join our discord.gg/TkBgNpp

這个星雲是一隻神祕 ê 花枝形宇宙雲，伊 tī 天頂足暗、嘛足大--ê。這幅圖 是 kā 30 點鐘久 ê 狹頻影像資料組合出來--ê，大細差不多是 3 粒月娘遐爾闊，就 tī 皇家星座 仙王座 遐。大花枝星雲是法國 ê 天文攝影師 Nicolas Outters tī 2011 年發現--ê。這是伊發現 ê 第四个天體，所以才會號做 Ou4。伊 ê 雙極結構 有夠清楚，是雙電離酸素原子 發出 ê 青藍色 發射線。因為大花枝星雲去予紅色 ê 水素發射線區 包 tī 外口，所以伊真正 ê 距離 kah 特性才會遮爾歹量。最近 ê 研究 認為講，Ou4 應該是 tī 發射星雲 Sh2-129 內底，差不多是 2300 光年遠。照這个推論，這隻宇宙大花枝可能是一个壯觀 ê 大角度噴流，是 ùi 星雲中心彼个高溫、大質量 ê 三星系統 HR8119 噴出來--ê。若真正是按呢，這隻實在有夠大隻 ê 花枝星雲，應該是比 50 光年閣較長。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20221012/ 影像：Tommy Lease 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap221012.html Powered by Firstory Hosting

Welcome to the Power Hour Podcast. In this episode the boys talk about the following. What are we drinkingWhat are we playingPatreon (thank Travis Lee for going from $2 to $5)Seller notes from PRGE https://twitter.com/kobunheat/status/1582206545349074944?s=46&t=pCldyF5Jiyic3hvKjI9YnQHellena Taylor lied about her offer https://twitter.com/jasonschreier/status/1584479145274527744?s=46&t=AhuBAnMWpUjCc2TRVio5DQLongest we spent on a section of a game to pass / beat it? (Kit)Sony blocks COD from GamePass https://www.gamingbible.co.uk/news/playstation-blocked-cod-from-game-pass-says-xbox-20221019RE4 Remake Trailer https://youtu.be/pQsyi4j1RqMSilent Hill 2 remake announced https://twitter.com/konami/status/1582840411512393729?s=46&t=5G1pvXgrBxAwf-PckiUEqQ GamersMad: thinking SH2 looks bad means you are old https://twitter.com/bawkbasoup/status/1583187336451751936?s=46&t=gTuWMHBm6yqGsvtufheEDA gamersmad: gamers […]

Czekając na tegoroczny wysyp hitów ogrywamy dwa tytuły AA, może nie jest to najwyższa półka ale przykuły nas do konsoli. Studio Spider zaoferowało całkiem przyjemny rpg-soulslike w XVI-to wiecznym Paryżu a debitutancki projekt Reply Games zaserwował nam slashera w stylu DMC. Poza tym newsy, Resident Evil Showcase i to na co bardzo czekaliśmy czyli Silent Hill Showcase. Gdzie zaprezentowano remake SH2 od polskiego Bloober Team oraz trzecią część filmu i inne gry z tego uniwersum które zadebiutują w przyszłości.

大蝎虎星雲是天頂上大 ê 星雲之一，是講咱以前哪會無啥注意著？伊 kah 仙女座星系 ê 角寸尺差不多平大，咱會當 tī 四跤蛇星座（蝎虎座） 揣著伊。咱若是用雙筒千里鏡，欲揣 發射星雲 是有較困難，因為伊 足暗--ê。毋閣就算是用大型天文望遠鏡嘛真歹揣，因為伊 ê 角寸尺傷大矣，差不多有 3 度 闊。這个星雲去 hŏng 編做是 Sharpless 126 (Sh2-126)，伊 ê 深度、闊度、雲波、kah 美麗，會當利用 kha-mé-lah 長時間感光 kā 翕落來欣賞。這是一張組合相片，是 kā 今年六、七月彼陣 tiàm 西班牙 IC 天文台 開 6 暗 ê 時間，用 5 種無仝色光 ê 濾光片，攏總翕 10 點鐘久 ê 時間，疊出來 ê 影像。Tī 大蝎虎星雲內底 發紅光 ê 水素 氣體，是去予 蝎虎座 10 這粒足光 ê 恆星激發--ê。伊就 tī 這个發紅光 ê 星雲中央，彼粒上光 ê 藍光星。這寡恆星 kah 星雲 離咱有 1200 光年 遠。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20220914/ 影像來源 kah 版權：Jarmo Ruuth, Telescope Live 文稿：Ata Sarajedini (Florida Atlantic U., Astronomy Minute podcast) 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap220914.html Powered by Firstory Hosting

這个望遠鏡景色 是一个光 iàⁿ-iàⁿ ê 發射線區。Ùi 遮看出去，是咱銀河盤面頂 有足濟星雲 ê 天鵝座。這个發紅光 ê 星際氣體塗粉雲，一般人攏 kā 叫做鬱金香星雲。伊嘛有 tī 天文學家 Stewart Sharpless 1959 年編 ê 目錄 內底，叫做 as Sh2-101。這个複雜美麗 ê 鬱金香星雲差不多有 70 光年闊。這蕊花就開 tī 8000 光年遠 ê 所在。Tī 天鵝座上邊仔 ê OB3 星協 內底有 O 型星 HDE 22701。這寡少年高能 ê 恆星發出紫外光輻射，kā 鬱金香星雲內底 ê 原子 離子化，驅動發射線。這个視野內底閣有 微類星體 天鵝座 X-1，是天頂上強 ê X-光 天體之一。Tī 這个宇宙鬱金香花葉 ê 正爿，咱會當看著較暗較藍 ê 衝擊波，彼是 ùi 藏 tī 星雲內底 ê 烏洞 噴出來 ê 噴流 驅動--ê。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20220901/ 影像：Peter Kohlmann 音樂：P!SCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap220901.html Powered by Firstory Hosting

Star and Cluster Formation in the Sh2-112 Filamentary Cloud Complex by Alik Panja et al. on Tuesday 20 September We present the star formation activity around the emission nebula Sh2-112. At a distance of $sim2.1$~kpc, this ion{H}{2} complex, itself 3~pc in radius, is illuminated by the massive star (O8,V) BD$+$45,3216. The associated molecular cloud extends in angular scales of $2fdg0times0fdg83$, corresponding to linear sizes of 73~pc by 30~pc, along the Galactic longitude. The high-resolution ($30arcsec$) extinction map reveals a chain of dust clumps aligned with the filament-like structure with an average extinction of $A_{V} sim 2.78$~mag, varying up to a maximum of $sim17$~mag. Our analysis led to identification of a rich population ($sim 500$) of young (average age of $sim 1$~Myr) stars, plus a numerous number ($sim 350$) of H$alpha$ emitters, spatially correlated with the filamentary clouds. Located near the edge of the cloud, the luminous star BD$+$45,3216 has created an arc-like pattern as the ionizing radiation encounters the dense gas, forming a blister-shaped morphology. We found three distinct young stellar groups, all coincident with relatively dense parts of the cloud complex, signifying ongoing star formation. Moreover, the cloud filament (excitation temperature $sim 10$~K) traced by the CO isotopologues and extending nearly $sim 80$~pc is devoid of ionized gas except at the dense cores (excitation temperature $sim$ 28--32~K) wherein significant ionized emission excited by OB stars (dynamical age $sim$ 0.18--1.0~Myr) pertains. The radial velocity is dynamic (median $sim -3.65$~km~s$^{-1}$) along the main filament, increasing from Galactic east to west, features mass flow to form the massive stars/clusters at the central hubs. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.09609v1

In this extra long episode of the podcast I am joined by friend of the show Jodie. Along with a lengthy introduction for you all to get and know her we also dive deep into two topics. We discuss Soul Hackers 2 sales numbers from Japan/Europe so far. Along with talk to Jodie about the pop up event Atlus hosted in London to celebrate the launch of Soul Hackers 2 recently. Follow Jodie on Twitter @Jodiede Check out her post on the SH2 event here: https://twitter.com/jodiede/status/1564012299500888065 Check out my Soul Hackers 2 review here: https://youtu.be/nBelK-5-Nbo Soul Hackers 2 DLC video: https://youtu.be/hvx1h14dykQ Support the podcast: Patron.com/SMTN Subscribe on YouTube Here: https://www.youtube.com/user/torchwood4SP Check out the Shin Megami Tensei Network podcast on iTunes: https://podcasts.apple.com/us/podcast/shin-megami-tensei-network/id1527210478 Spotify: https://t.co/wOXqDqPqoc?amp=1 Find us online Twitter @SMTNetwork @Torchwood4sp Join the Facebook group: https://www.facebook.com/groups/SMTNetwork Join our discord.gg/TkBgNpp

Silent Hill: Secuelas: “Silent Hill: Revelation” (2012). Presupuesto: $50 M USD. Recaudación: $100 M USD. Año: 2006. Director: Christophe Gans. Actores: Radha Mitchell (Rose DaSilva), Sean Bean (Christopher DaSilva), Laurie Holden (Cybill Bennet) y Jodelle Ferland (Alessa Guillespie). Cronología:No hay que olvidar que para el 2006, cuando salió la película, ya existía el videojuego original del 99, también SH2 de 2001 y SH3 del 2003. Es decir, había más contexto en cuanto a la historia, personajes y sobre el pueblo. Esto tendría un impacto en la primera adaptación cinematográfica.Reparto: Radha Mitchell (Rose DaSilva): esta actriz no es muy popular, la recuerdo en el remake de George A. Romero “The Crazies”. Sean Bean (Christopher DaSilva): Actor de gran trayectoria y hasta donde se dice, todos sus personajes mueren. Tal vez lo recordemos más como Boromir en “TLOTR” y Ned Stark en “GOT”. Laurie Holden (Cybil Bennet): recordada por su trabajo en la serie “X-Files” y después en “The Walking Dead”. ¿De qué trata la película?El matrimonio DaSilva empieza a preocuparse debido a que su hija adoptada, Sharon (Alessa), sufre de pesadillas y sonambulismo, donde a menudo pronuncia las palabras “Silent Hill”, sin recordar nada al despertar.Rose investiga un poco sobre ese pueblo y decide llevar a su hija con el propósito de ayudarla a recordar sobre su vida antes de ser adoptada. Al llegar a Silent Hill, descubre un sitio cubierto de cenizas y neblina, sufre un aparatoso accidente y Sharon desaparece. Rose se adentrará hasta las entrañas del lugar para localizar a su hija, sin embargo, encontrará un terrible secreto.Antecedentes:¿Qué tanto se acerca la adaptación al juego? De entrada, en el juego es el esposo, Harry, quien se dirige a Silent Hill con su hija Cheryl para tomar unas vacaciones. Al entrar al pueblo, una niña se atraviesa haciendo que, de un volantazo, el hombre pierda el control del vehículo y queda inconsciente por el impacto. Al despertar, Cheryl no está y va a buscarla.Toda esta introducción es casi igual al juego en la película. Con la diferencia de que, en lugar de Harry, tenemos a Rose y el nombre de la hija adoptiva es Cheryl en lugar de Sharon.Además, contamos con el pueblo lleno de niebla y ceniza, en la película se explica que esto se debe al carbón ardiente bajo la ciudad. Sabemos que Rose escapaba de la policía, para llegar al pueblo. En ambas propuestas, logran el encuentro entre Cybil y Rose.¿Qué es lo que ocasiona que el pueblo esté lleno de neblina?Igual se preserva bastante bien este hecho, el horror detrás de la historia, muy crudo. En ambos casos, Alessa sufrió quemaduras fatales debido a un ritual que traería al dios del culto al que Dahlia lideraba. Como muestran en la película, Alessa es inmolada a sus siete años mediante un sacrificio horrible y lento.En su desesperación, la joven utiliza una proyección astral para separarse en dos versiones: la que está en sufrimiento y la feliz. Esto interfiere con el ritual porque, sí, logran poner la semilla del embrión maléfico en Alessa, pero no puede nacer porque su alma está dividida.Las heridas fatales de Alessa son sanadas por medio de un hechizo que la mantiene con vida. Dahlia quiere que su contraparte, Cheryl (en la película Sharon) regrese a Silent Hill para que se unan y pueda nacer la deidad prometida. Sin embargo, mantiene escondida a su hija en el sótano del hospital, a cargo de una enfermera. El médico –cultista– le administra alucinógenos y Dahlia la hace sufrir para que atraiga a Cheryl. ¿Cómo? Quiere intensificar el deseo de cometer un suicidio, pero en su estado, no puede hacerlo.En la película vemos a Dahlia, la madre vagabunda, aislada y viviendo en remordimiento por entregar a su hija. Sin embargo, en el juego, Dahlia era la líder del culto. De igual forma, la hija de Dahlia lleva el nombre de Alessa, la niña demonio que ha puesto la maldición sobre Silent Hill.La parte de Alessa que está enojada quiere venganza y se encuentra en continuo sufrimiento y alucinaciones.La enfermera que aparece en la película participa en el juego. Lisa, quien estaba a cargo de Alessa mientras era torturada y drogada, empieza a sangrar por los ojos, ya que no puede soportar verla.En el juego, Harry salva a Cybill (opcional) de morir y después de derrotar a la deidad reencarnada, huyen juntos.Es bien sabido que, según las decisiones del jugador, hay diferentes finales.En el caso de la película, Cybill termina inmolada también, quemada como bruja hasta morir.Derrotada la deidad, con la última energía de Alessa, reencarna un bebé, el cual Harry se lleva de regreso a su casa.En la película, Rose salva a Sharon de ser ejecutada. No existe la deidad como tal, sino la líder del culto que vive en el limbo sin aceptar que ellos son los pecadores. Cuando Alessa quiere vengarse de ellos, no puede porque se resguardan en la iglesia. Por eso guía a Rose con el propósito de que entre y por fin pueda hacerlos pagar.Al final, se entiende que Rose regresa a su casa con Sharon, sin embargo, se quedó en el Otro Mundo, ese limbo extraño.Mitología:Previo a la colonización de USA, el sitio se llamaba “El lugar del Silencio” o “Espíritus silenciados”. La leyenda dice que un espíritu no es solo de almas vivas, sino también rocas, agua, etc. El lugar no era malo por naturaleza, pero debido a las cosas ocurridas, cambió.El pueblo manifiesta los pensamientos más oscuros de las personas que están ahí.La conquista expulsa a los nativos, los nuevos habitantes le cambian el nombre. Una epidemia arrasa con ellos y los pocos sobrevivientes huyen. Más adelante construyen una prisión y un hospital debido a otra epidemia. La prisión cierra, se descubre la mina de carbón, entra en operación y la zona crece económicamente.Durante la guerra civil americana se construye otra prisión. Gente comienza a desaparecer.La prisión cierra y se vuelve un lugar turístico. Más gente muere, incluyendo gobernadores.Los cultistas son los culpables de las desapariciones.Debido a tanta corrupción en ese espacio sagrado y espiritual, es que el poder de esa tierra comenzó a reaccionar con más fuerza hacia sus ocupantes. Cada vez que alguien la toca, se expresaría lo que tuviera reprimido en lo más profundo de su ser.La neblina y el otro mundo:Es una delgada línea entre la realidad y los sueños.Los desarrolladores del juego explican estos cambios entre “el lado correcto” y “el lado inverso”. Ponen de ejemplo que, cuando uno duerme, puede estar en la fase de “sueño ligero” y “sueño REM (rapid eye movement)” que es cuando estamos soñando. De la misma forma actúa Silent Hill, hay momentos en la zona ligera, con la neblina y algo de luz... Pero al momento de alcanzar la zona REM, ahí nos adentramos a la peor pesadilla, junto a la oscuridad. Así, el ciclo se repite.Según los desarrolladores, ninguno de estos espacios es la realidad. La neblina representa los pensamientos que tiene y cómo los espíritus se aparecen en ellos. Conforme empiezas la espiral descendiente a las angustias y represiones, caes en el lado inverso y las manifestaciones se vuelven horribles.El mundo inverso:Según qué tan corrupto es su espíritu, será el lado inverso. ¿Por qué se llama así? En teoría es porque toma algo que conoces, algo que existe y lo transforma en su polo opuesto, en su lado más terrible.Dios (teoría de Max Derret):El dios al que La Orden (el culto) hace referencia, es muy probable que sea Baphomet –dios de lo absoluto–, se le conoce así porque es todo: tiene cara de cabra, cuerpo humano, tiene partes femeninas y masculinas, representa la luz y la oscuridad, tiene escamas y alas.Por otro lado, Carl Jung en su libro “Aion” dice que todos los humanos quieren convertirse en cosas mejores. Le llamó a la cumbre de este proceso de mejora como “Sí-mismo” o “The Self”. Este es el ideal máximo, equivalente a Dios.En varias religiones hay representaciones de Dios que alcanzan ese estado al llegar a un balance último entre lo mejor y peor de ellos. Por ejemplo, los cristianos quieren llegar a ser como Jesús, quien tuvo que vivir un infierno, ser crucificado y asesinado para resucitar como Dios, en su nivel más poderoso. Al lograr esto, se vuelve un todo: fue material y espiritual, fue malo y bueno, fue único (Jesús), pero universal porque es todo lo que existe, fue temporal como humano, pero también es eterno.Así, en “Silent Hill” vemos ese concepto en la deidad que quieren revivir y lo que se manifiesta en el pueblo. Está basada en el absoluto. El absoluto puede tomar varias formas según quién lo perciba. Por otro lado, La Orden, como culto está dispuesta a recorrer el camino del sufrimiento, sacrificios y demás, a cambio de llegar a un paraíso libre de sufrimiento.¿Cuál fue la contribución de la película al cine de horror?Las adaptaciones de videojuegos a películas por lo general no tienen buenos resultados, pero con “Silent Hill” se hizo un excelente trabajo.Basada en el primer título del videojuego del mismo nombre, nos presenta un gran tributo a la historia y personajes. Para el año del estreno ya contaban con cuatro títulos publicados.Tuvo buena recepción, pero tal vez se esperaba más por el potencial del universo de los videojuegos y por lo popular que estos son.Aunque mantiene la base de la historia, poco a poco la película se va alejando de Harry Mason. Inclusive toma elementos de otros títulos de la franquicia como las enfermeras y Pyramid Head del “Silent Hill 2” o la música de “Silent Hill 3”. Tal vez una estrategia para atraer a los fans.¿Por qué incluir a Pyramid Head?Pyramid head es un personaje icónico de “Silent Hill” y presenta una simbología importante: es la encarnación de la culpa y la ira.Es evidente que el personaje sale en “Silent Hill 2” por primera vez y que, muchos fans se enojaron porque no tenía nada que ver en la primera parte. Pero, si lo vemos desde un punto de vista simbólico, más allá de ser fan service e inspirar un gran miedo, representa todos los pensamientos oscuros que tenemos y que reprimimos.Como referencia, en “SH2”, el protagonista vive con una culpa terrible por haber asesinado a su esposa. No solo eso, previo al acto, lo acosan sentimientos de desesperación, enojo o represión sexual.Cuando vemos a Pyramid head, en varias ocasiones está realizando actos sexualizados y físicamente es un carnicero.En la película, la aparición de Pyramid head representaría aquella culpa de los actos horrendos realizados a Alessa y es el verdugo que va a castigar al pueblo. Actúa como protector.Se dice que también representa la figura paterna de Alessa. De cierta forma, en la película, debido a que Alessa nació del pecado, pues Dahlia era madre soltera, el culto decidió castigarla. Esto no hubiera sucedido si Alessa hubiera nacido de un matrimonio típico.Producción:Christopher Gans (“Brotherhood Of The Wolfes”) intentó por casi cinco años obtener los derechos de Konami para filmar una película de “Silent Hill”. Tanto Konami Japan y Team Silent, en ese entonces equipo de desarrollo de los videojuegos, se involucraron en la producción del filme.El escritor Roger Avary explicó que cuando su padre era niño, un ingeniero de minas solía contarle historias sobre el pueblo de Centralia, en Pensilvania, EE. UU., donde los depósitos de carbón de una mina local se incendiaron, lanzando gases tóxicos que obligaron a los habitantes a evacuarlo indefinidamente. Esta historia sirvió como base para “Silent Hill” en la película.La producción también contrató al compositor de la música de los videojuegos, Akira Yamaoka, y eso le da una mayor atracción, sin duda te transmite la sensación de estar jugando algún título de la saga.Gans pensó en hacer la película un universo de mujeres. La inclusión del esposo y el detective fueron elementos que la productora les hizo introducir.Al hacer el personaje principal mujer, Rose, considera que la película tiene una dirección clara: es un matriarcado, las mujeres están a cargo de toda decisión relevante y existe hermandad entre ellas, pueden sentir simpatía a través del hecho de ser madres, explorar desde la concepción divina. Lo vemos en la religión cristiana, pero en la historia se aborda como una deidad maligna, además de la fuerte simbología que existe respecto a la caza de brujas. Son concepciones con las cuales la audiencia está familiarizada.Akira Yamaoka menciona que el juego de “Silent Hill” se basa en todos los miedos y ansiedades reprimidas que tenemos. Cada persona sufre de manera diferente. Esas figuras deformadas representan dichos aspectos.Los efectos especiales son muy buenos, pero, además, el director buscó en la medida de lo posible que las criaturas humanoides fueran como esculturas, evitando el uso de CGI. Todas son actores y realzan la película, inspiran mayor miedo debido al impacto visual y por lo viscerales que son.Curiosidades:El director Gans, durante las grabaciones, tenía una TV con un PS2 y jugaba “Silent Hill” para que los actores y cinematógrafos pudieran ver lo que quería emular en algunos ángulos y movimientos.La película no cuenta con el elemento “JumpScare”. Se centra en la atmosfera y los sonidos, tal cual lo hacen en el videojuego.Créditos:Radio Horror es producido por Caro Arriaga y Rael Aguilar.Edición por Matías Beltrando desde Destek Soporte.Música:Closing Theme Hounds of Love por Dan Luscombe (Intro), Insiders por Joe Crotty (Intro), Patchwork por Patchworker f.k.a. [friendzoned] (Spoilers) y Nightlong por FSM Team (Outro).★ Support this podcast on Patreon ★

這寡 幽靈形體 浮 tī 皇家星座 仙王座 ê 夜空，kah 厚塗粉、寬闊 ê 星雲濫做伙。是講，這款形體是宇宙塗粉雲 去予 較暗 ê 恆星反射光 照--出來 ê。In 毋是 tī 恁兜厝邊 遐爾近 ê 所在，是 tī 閣較遠 ê 所在。In tī 銀河盤 ê 面頂、tī 仙王座閃焰 分子雲複合體 ê 邊仔墘，差不多離咱有 1200 光年遠。Tī 這个視場，天星滿滿。伊 ê 正爿有去予編做 vdB 141 抑是 Sh2-136 ê 天體，嘛叫做 幽靈星雲。這个大細比 2 光年較闊，嘛比其他大部份較光 ê 幽靈幻影閣較光。星雲內底 有 tī 恆星形成 早期階段，恆星 實密 ê 核心 崩陷 ê 信號。這个奇怪色調 ê 塗粉是反射 NGC 7023 內底 高溫少年恆星 ê 藍光。伊嘛叫做尾蝶花星雲，to̍h tī 這幅圖 ê 中央倒爿遐。Tùi 這个烏暗背景來講，伊實在是足出眾 ê。Tī 這幅闊幅望遠鏡影像內底，這个足

這个宇宙氣波去予大質量恆星 ê 高溫、高速恆星風吹 kah 遮爾大。伊去予編做 Sharpless 2-308，tī 大隻狗（大犬座）方向 5000 光年遠 ê 所在，比一粒月娘 tī 天頂 ê 寸尺閣較闊。按照這个距離來推算，這个直徑 差不多是 60 光年長。產生這个氣波 ê 大質量恆星是 Wolf-Rayet 星，to̍h 是星雲 中央附近 上光彼粒。Wolf-Rayet 星 ê 質量比太陽閣跤大 20 倍，伊應該是大質量恆星演化過程中，變做超新星進前 一个較短 ê 階段。Wolf-Rayet 星 ê 高速恆星風 tī 演化早期，會掃過行較慢 ê 物質，製造氣波形體 ê 星雲。這个 去予風歕出來 ê 星雲差不多有 7 萬歲 矣。這幅深空影像 ê 狹頻濾鏡有翕著較暗 ê 發射線。影像內底上主要 ê 部份是發光 ê 離子化 酸素原子，tī 遮 kā 標做 藍色 ê。SH2-308 看起來 真古錐 ，伊嘛叫做海豬頭星雲。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20211021/ 影像：Nik Szymanek 音樂：PiSCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap211021.html Powered by Firstory Hosting

The Src-family kinase Lck regulates T-cell development, activation, proliferation, and immune synapse dynamics. These are the initiation phases of TCR signaling. Upon antigen presentation via the APC- TCR immune synapse, Lck phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAMs) of the TCR-associated CD3 membrane protein domains. Phosphorylated ITAMs function as a molecular platform for tandem SH2 domains located on the tyrosine kinase Zap-70, initially activated by Lck. Lck kinase activity is regulated at two canonical phosphorylation sites Tyr394 and Tyr505, wherein auto-transphosphorylation of Tyr394 in the kinase domain erupts a relaxed/active conformation but phosphorylation of Tyr505, located at the C-terminus, by the tyrosine kinase Csk results in an inactive enzyme. References Longev Healthspan. 2012; 1: 6 SCIENCE ADVANCES•19 Jun 2019•Vol 5, Issue 6 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Jesus heals a leper by touching him--even though leprosy is contagious! (Matthew 8:1-4; Mark 1:40-45) SH2 #kids, #storiesforkids, #bedtimestoriesforkids, #biblelessonsforkids, #biblestoriesforkids, #christianpodcastsforkids, #roncarriewebb, #fishbytes4kids, #jesusisgreater, #jesusourhealer, #jesushealedthemall, #healing

Jesus heals a leper by touching him--even though leprosy is contagious! (Matthew 8:1-4; Mark 1:40-45) SH2

Tī 北方星座 仙王座 ê 方向 這个 10 度闊 ê 視場內底，有湠開 ê 發射星雲 IC 1396 kah SH2-129 相濫 ê 發光星際氣體，kah 塗粉烏雲。伊是去予中心 ê 藍色恆星 IC 1396（倒爿）激發 ê。伊有幾若百光年闊，離咱有 3000 光年遠。Tī 中央正爿下面是一个奇妙 ê 烏暗外形，內底有一个交纏 ê 烏暗雲，to̍h 叫做 象管星雲。伊有幾若十光年遐爾長，內底有恆星形成 ê 基本物質，嘛有藏 原恆星 tī 內底。這幅圖正爿 ê 發射光是 SH2-129，伊有幾若个光節 kah 掃轉來 ê 雲脊，to̍h chhāi tī kah 地球差不多遠 ê 所在。因為按呢，伊閣有一个較有名 ê 名，to̍h 叫做 飛行夜婆星雲。Tī 飛行夜婆星雲內底，除了這个皇家宇宙動物園，閣有最近變有名 ê Ou4，大花枝星雲。伊是較暗 ê 藍色發射光。 ——— 這是 NASA Astronomy Picture of the Day ê 台語文 podcast 原文版：https://apod.nasa.gov/ 台文版：https://apod.tw/ 今仔日 ê 文章： https://apod.tw/daily/20210723/ 影像：Patrick Hsieh 音樂：PiSCO - 鼎鼎 聲優：阿錕 翻譯：An-Li Tsai (NCU) 原文：https://apod.nasa.gov/apod/ap210723.html Powered by Firstory Hosting

Federated Farmers President David Clark said floodwaters in Canterbury have exceeded warnings "by a huge magnitude" and multiple rescue operations are taking place.One person is awaiting rescue by helicopter to get out of a flooded area as torrential rain hits Canterbury."It's a really serious situation here in Canterbury, the rivers are breaking in multiple places," he said.Clark has been helping with rescues, including a car that has been swept out in the floods at 4.30am where fire and emergency crews couldn't get to, and a farmer being trapped in a tractor by the floodwaters."Key message from Federated Farmers today is that safety is paramount, don't put your own life in danger," he said."We've seen multiple rescues, with machinery having to go out in deep floodwaters to rescue people."Police were called to assist a fire crew in a rescue emergency on Walkhams Rd at 8am this morning, a police spokeswoman said."It appears one person needs assistance to get out of a flooded area," she said."No injuries, they're just awaiting rescue at the moment. A helicopter has been called."A storm chaser at Canterbury Snow and Weather Watch is expecting multiple rivers to burst their banks today after the worst weather he has seen in a decade.The region is being lashed by torrential rain, causing widespread flooding and road closures, including the stretch from Springfield to Castle Hill on SH73, the main route to the west coast."We're hearing that a lot of the rivers on the Canterbury Plains, which people live very close to and normally run dry, are running at the highest levels on record," Josh Oliver said."People are pretty concerned. Yesterday people were a bit complacent about this event, we tried to warn people and it's now coming into fruition."Flooding of the Avon River in Christchurch. Photo / Hamish ClarkOliver said this was a "once in a lifetime event", it had been pouring for the past 24 hours, and there was still about 30 hours of the warning period to go."We've just heard that Mount Somers has already hit 300mm, which was the upper level of what the warning was for ... we're well on task to hit 600mm, which in New Zealand is almost unheard of, let alone in Canterbury."Oliver, who is based in Springfield, said he was out this morning and had seen surface flooding and atrocious driving conditions."People really shouldn't be out unless they absolutely have to," he said."I normally don't get worried about a weather event, I more enjoy the thrill of going out and chasing it, but this one has gotten me worried.He said the Heathcote River burst its banks in Christchurch last night "and it's only going to get worse from here"."Multiple rivers would burst its banks this afternoon I would say."Other parts of the country can expect thunderstorms as a complex low settles over New Zealand.For only the second time ever, MetService issued a rare red warning for heavy rain for Canterbury, south of Amberley. That warning will be valid until Monday at 11am.Civil Defence Emergency Management Canterbury is warning people to stay away from floodwaters and turn off electricity to avoid short circuits if water enters the home."Move livestock to paddocks that allow them to move away from floodwaters, are not at risk from landslides and are not close to power lines," it said."Check on neighbours and help anyone who might need assistance."Christchurch residents were warned the deluge would most likely reach dangerous levels, and there were reports some streets were already water-logged.This morning at 5.48am however, MetService has lifted road snowfall warnings at Arthur's Pass and Lewis Pass.Slips have also closed roads overnight.Tiniroto Rd in Gisborne was closed because of a large slip and will remain closed until contractors reassess the situation this morning.Motorists are being advised to use an alternate route between Gisborne and Wairoa, such as SH2.The stretch from Springfield to Castle Hill on SH73 also...

“Can we liquidators defend this appeal, and use someone else’s lawyers?” ___ A dispute between two Dirs and equal shareholders of a mining Co led to it being wound up. Before the windup SH1 brought a derivative action on behalf of the Co against SH2 and related entities. The claim succeeded re revenue from one mine which SH2 diverted away from the Co to their own interests, and failed in relation to redirected revenue from another mine. SH2 appealed. SH1 applied to lodge a cross-appeal on behalf of the Co. The liquidators came before the Court to seek s 90-15 advice including that they would be justified in: (i) causing the Co to defend SH2’s appeal (ii) not opposing SH1’s cross-appeal (iii) instructing the same lawyers SH1 used for the derivative action Advice was given. Re (i) the liqs were justified in defending the appeal: [40] Re (iii) the liqs were justified as it would be in the best interests of the Co to making use of the earlier lawyers’ case specific knowledge: [46], [47], [56] Re (ii) the liqs were justified in not opposing as SH1 bore many of the risks (including of an adverse costs order) and there was potential significant upside for the Co: [65] The liqs’ costs of the proceedings were to be costs of the winding up: [68]

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.30.361790v1?rss=1 Authors: Li, S., Zou, Y., Zhao, D., Yin, Y., Song, J., He, N., Liu, H., Li, L., Huang, H. Abstract: Protein engineering through directed evolution is an effective way to obtain proteins with novel functions with the potential applications as tools for diagnosis or therapeutics. Many natural proteins, largely antibodies as well as some non-antibody proteins, have undergone directed evolution in vitro in the test tubes in the laboratories around the world, resulted in the numerous protein variants with novel or enhanced functions. In this study, we constructed a Fyn SH2 variant library by randomizing the 8 variable residues in its phosphotyrosine (pTyr) binding pocket. Selection of this library by a pTyr peptide from MidT antigen led to the identification of SH2 variants with enhanced affinities to the peptide, compared to the wild type SH2, by EC50 assay. Fluorescent polarization (FP) was then applied to quantify the binding affinity of the newly identified SH2 variants. As a result, three SH2 variants, named V3, V13 and V24, have comparable binding affinities with the previously identified SH2 triple-mutant superbinder (refer to Trm). Biolayer Interferometry (BLI) assay was employed to disclose the kinetics of the binding of these SH2 superbinders, in addition to the wild type SH2, to the phosphotyrosine peptide. The results indicated that all the SH2 superbinders have two-orders increase of the dissociation rate when binding the pTyr peptide while there was no significant change in their associate rates. The previously identified SH2 superbinder Trm as well as the V13 and V24 discovered in this study have cross-reactivity with the sulfotyrosine (sTyr) containing peptide while the wild type SH2 does not. Intriguingly, though binding the pTyr peptide with comparable affinity with other SH2 superbinders, the V3 does not bind to the sTyr peptide, implying it binds to the pTyr peptide with a different pattern from the other superbinders. The newly identified superbinders could be utilized as tools for the identification of pTyr-containing proteins from tissues under different physiological or pathophysiological conditions and may have the potential in the therapeutics. Copy rights belong to original authors. Visit the link for more info

En este episodio hablamos de cómo percibimos el olor y qué nos dice la química respecto a los distintos olores. Notas:Redes sociales:Puedes seguirnos en Twitter, Instagram y Facebook para estar al tanto de cualquier novedad.Si quieres aprender más sobre Neurociencia, puedes seguir a Clara en su canal de YouTube “Cerebrotes”, donde sube vídeos semanales hablando de Neurociencia y Psicología. También la puedes encontrar en Twitter, Instagram y Facebook con el nombre artístico de Cerebrotes. A Hugo sólo puedes seguir por la calle, porque no está en redes sociales.-Referencias de Clara:-Artículo científico procesamiento de la recompensa del olfato en el cerebro:https://www.oxcns.org/papers/542%20Rolls%202015%20Taste,%20olfactory,%20and%20food%20reward%20value%20processing%20.pdf-Artículo científico mecanismos percepción olfativa:https://pubmed.ncbi.nlm.nih.gov/20700142/-Artículo cientifico corteza piriforme:https://www.pnas.org/content/111/47/16931-Artículo divulgativo sobre estudio relación olfato y memoria: https://www.sciencedaily.com/releases/2018/07/180723155726.htm-Artículo científico papel hipocampo relación olfato y memoria:https://www.nature.com/articles/s41467-018-05131-6-Artículo científico Alzheimer y olfato: https://www.sciencedirect.com/science/article/abs/pii/S0197458005002216-Referencias de Hugo:Relación entre estructura y olorhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244502/https://advances.sciencemag.org/content/4/2/eaao6086/tab-pdfhttps://academic.oup.com/chemse/article/36/6/539/478467https://app.dimensions.ai/details/publication/pub.1041592801Compuestos sulfurados en el ajohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731019/Química de los malos oloreshttps://blogs.scientificamerican.com/the-curious-wavefunction/chemists-and-bad-smells-and-sulfur-a-productive-pairing/Síndrome del ácido isovaléricohttps://www.sciencedirect.com/science/article/abs/pii/S0022347667801604Pauling y Matt(ew Meselson)http://library.cshl.edu/oralhistory/interview/cshl/research/graduate-work-linus-pauling-applying-chemistry-bio/Compuestos y su olor:Hidrocarburos aromáticos. Cetonas, éteres y ésteres. Aldehídos. Ácidos. Oxidación de alcohol a aldehído y a ácido. Aminas. Compuestos organosulfurados y SH2. Para conocer la estructura molecular de estos compuestos, accede a la página: https://www.podcastidae.com/programa/el-olor-mentes-covalentes-14/

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.28.271809v1?rss=1 Authors: Bobone, S., Pannone, L., Biondi, B., Solman, M., Flex, E., Canale, V., Calligari, P., De Faveri, C., Gandini, T., Quercioli, A., Torini, G., Venditti, M., Lauri, A., Fasano, G., Hoeksma, J., Santucci, V., Cattani, G., Bocedi, A., Carpentieri, G., Tirelli, V., Sanchez, M., Peggion, C., Formaggio, F., Den Hertog, J., Martinelli, S., Bocchinfuso, G., Tartaglia, M., Stella, L. Abstract: Mutations of PTPN11, the gene coding for the Src homology 2 domain-containing phosphatase 2 (SHP2), cause childhood leukemias and developmental disorders. SHP2 inhibitors targeting the catalytic site or an allosteric pocket lack specificity or are ineffective on pathogenic variants. In addition, several data indicate that increased association with cognate proteins, through its SH2 domains, rather than enhanced catalytic activity, is the main effect of mutations causing hyperactivation of SHP2-mediated signaling. We developed peptide-based molecules with low nM affinity to the N-SH2 domain and high specificity. These molecules bind to pathogenic variants of SHP2 with an affinity up to 20 times higher than to the wild-type protein, in contrast to allosteric inhibitors, and were able to revert the effects of a pathogenic SHP2 mutation in zebrafish embryos. Our results provide a novel route for SHP2-targeted therapies and a tool to investigate the role of protein-protein interactions in the function of SHP2. Copy rights belong to original authors. Visit the link for more info

It's a bit tricky to ramp up into processing one of the Most Important Games Of All Time, but that's we try to do here. Basically, Rachel and Brock do a good introduction episode to the story, themes, and spooky stuff from Silent Hill 2. We're really going to have to dig into SH2 more in the future, and we're hoping to have some Real Silent Hill Specialists do guest episodes. But right now, here's a very fine starting point. Thanks for listening and we'll have Silent Hill 3 up before Halloween!

Join the gaming Duo Keep 'et Classy (Aaron and Gabriel) as they discuss Australian life, video games and more. This week the boys discuss patreon, Nvidia Ray Tracing, Silent Hill 2 Enhanced (http://www.enhanced.townofsilenthill.com/SH2/) and more

This past week has been a downer for me news-wise, what with the news that the US government (through USAID) is suspending its support of the Ministry of Health's departments due to corruption and weak accounting practices. This support is worth KES 2.1 billion, and affects crucial health services. We also found out that the Jubilee campaign has engaged Cambridge Analytica, a firm said to be behind Donald Trump's victory in the US and the Brexit vote in Britain. I've been asking myself: what does this mean? Press play to find out. Resources USAID suspends funding for health ministry departments United States Agency withdraws Sh2.1 billion health support Launch of $650 Million U.S. Government KEMSA Medical Commodities Program The #LipaKamaTender Movement What is 1.66 Billion? On Resistance Dear Uhuru Kenyatta The Anatomy of a Lootocracy Kenya at 52 Uhuru hires data firm behind Trump, Brexit victories Cambridge Analytica Explained: Data and Elections Trump Data Gurus Leave Long Trail of Subterfuge, Dubious Dealing The great British Brexit robbery: how our democracy was hijacked

Now we are going to cover Space Rabbits! This conversation took place between Houston and the Apollo 11 crew just before the first Moon landing in 1969:         Houston: Among the large headlines concerning Apollo this morning, is one asking that you watch for a lovely girl with a big rabbit.         An ancient legend says a beautiful Chinese girl called Chang-O has been living there for 4,000 years. It seems she was banished to the Moon because she stole the pill of immortality from her husband.         You might also look for her companion, a large Chinese rabbit, who is easy to spot since he is always standing on his hind feet in the shade of a cinnamon tree. The name of the rabbit is not reported.         Michael Collins: Okay. We’ll keep a close eye out for the bunny girl. Having said that, lets look a little deeper into Rabbit's in space. Now from Wikipedia, Animals had been used in aeronautic exploration since 1783 when the Montgolfier brothers sent a sheep, a duck, and a rooster aloft in a hot air balloon (the duck serving as the experimental control). The limited supply of captured German V-2 rockets led to the U.S. use of high-altitude balloon launches carrying fruit flies, mice, hamsters, guinea pigs, cats, dogs, frogs, goldfish and monkeys to heights of up to 144,000 feet (44,000 m). These high-altitude balloon flights from 1947 to 1960 tested radiation exposure, physiological response, life support and recovery systems.  The U.S. high-altitude manned balloon flights occurred in the same time frame, one of which also carried fruit flies. Animals in space originally served to test the survivability of spaceflight, before human spaceflights were attempted.  Later, animals were also flown to investigate various biological processes and the effects microgravity and space flight might have on them.  Bioastronautics is an area of bioengineering research which spans the study and support of life in space. To date, seven national space programs have flown animals into space: the Soviet Union, the United States, France, Argentina, China, Japan and Iran. A wide variety of animals have been launched into space, including monkeys, dogs, and insects.  The United States launched flights containing monkeys and primates primarily between 1948-1961 with one flight in 1969 and one in 1985.  France launched two monkey-carrying flights in 1967.  The Soviet Union and Russia launched monkeys between 1983 and 1996.  During the 1950s and 1960s, the Soviet space program used a number of dogs for sub-orbital and orbital space flights. Back in the late 1950’s space programs in the Soviet Union (Russia) and United States used animals to make high altitude and orbital flights.  Tragically, many times they were one-way trips. It was inhumane on a lot of levels. Marfusha, the first rabbit astronaut, made a high altitude test flight on July 2, 1959 aboard an R2-A rocket.  Following this on August 19, 1960, another rabbit was sent into space on the Soviet Sputnik 5 and returned alive along with its fellow animal astronauts, which included dogs and mice. There are a few photo's of unlikely space travelers, such as a white dog and a grey rabbit, ad two dogs and a rabbit available on line. Otvazhnaya (the dog) and Marnushka (the rabbit) braved a high altitude test flight on July 2, 1959 aboard an R2-A rocket.  Another dog, Snezhinka, also went on the flight.  Fortunately, all three animals were recovered successfully.  This rabbit went on to make five more successful high altitude test flights in the following year. Then in August 1960, two dogs, Belka and Strelka, an unnamed gray rabbit, 40 mice and 2 rats, were launched in Sputnik 5. Again in September 1962 a rabbit was aboard the Artemis that made 12 complete earth orbits. However, Artemis collided with space debris and sustained critical damage. Fortunately, the rabbit was recovered unharmed 933 miles off the east coast of Brazil. NASA’s History of Animals in Space web page states, after the manned lunar landing of Apollo 11, the role of animals was limited to the status of "biological payload." The range of species broadened to include rabbits, turtles, insects, spiders, fish, jellyfish, amoebae, and algae. Although they were still used in tests dealing with long-range health effects in space, tissue development, and mating in a zero-g environment, etc., animals no longer made the front pages. One exception to this was one of the last Apollo flights, Skylab 3, which launched on July 28, 1973. On board were Anita and Arabella, two common Cross spiders. Tests were set up to record the spiders' successful attempts to spin webs in space. Now this is also from NASA. Most recently, Animals go into space to help conduct scientific research only when absolutely necessary. Researchers prefer to research with computer models, or by involving the astronauts directly. For some experiments, however, only animals will work. Sometimes the situations need to be closely controlled-such as a monitored diet. Human astronauts generally aren't willing to agree to eat the same amount and type of food, so this experiment would be a burden to them.  Animals, however, always have monitored feedings. Taking animals into space requires special considerations. If a group of laboratory mice were to fly aboard the next Space Shuttle mission, what would be needed? Traditional aquarium-style cages don't provide enough traction for mice to walk around; instead, space mice have wire mesh cages so their toes can grip a rougher surface. Wood chips couldn't be used for bedding; they wouldn't stay in place. Gravity-feed water bottles wouldn't work; pressurized water containers are needed instead. Bowls of dry food aren't practical, so compressed food bars are provided instead. As for how to clean the cages, a special waste containment system has been created to keep everything in its place. Do the animals like living in microgravity? Does floating instead of walking confuse them? "Amazingly, they adapt very quickly," says Laura Lewis, a member of NASA Ames Institutional Animal Care and Use Committee. "Within 5 minutes, mice are floating in their living spaces, grooming themselves, and eating, just as they would on Earth." "Good science sets up hypotheses for an experiment, but sometimes the result is not what you expect," says Lewis. "While we test our projects on the ground and in simulators, once we get into space, we are sometimes surprised by what we learn." Baby mammals have a hard time in space because they normally huddle for warmth-and in space, it's hard to huddle when bodies drift and float. It's also difficult for babies to nurse when they can't locate their mother's nipple. Animals that travel in space are cared for ethically and humanely, Lewis says. "The Institutional Animal Care and Use Community looks at the most humane alternatives for taking animals into space," she says. "Regulations for animal research are more intense than for using people in research because people can give consent. Animals can't object, so people need to work on their behalf. Animal housing rules are more extensive than the requirements for human children day care centers. NASA facilities that house animals for research are accredited by an organization that requires proof that animals are cared for in a facility that meets those standards." The United States Department of Agriculture Animal Welfare Act and the Public Health Services Policy Act protect research animals and set minimum standards. "Animals don't go into space very often," Lewis says. "There are so few flight opportunities for a mission to include animals, so the project has to be pretty important to earn a spot on any trip into space. When animals do make the trip, their welfare is a key concern." There are a couple of websites touting the use of rabbits as a food source for human space colonies on Mars. Over the past 50 years, American and Soviet scientists have utilized the animal world for testing. Despite losses, these animals have taught the scientists a tremendous amount more than could have been learned without them. Without animal testing in the early days of the human space program, the Soviet and American programs could have suffered great losses of human life. These animals performed a service to their respective countries that no human could or would have performed. They gave their lives and/or their service in the name of technological advancement, paving the way for humanity's many forays into space. http://history.nasa.gov/animals.html http://hopperhomebunnyblog.blogspot.com/2011/11/one-hop-for-mankind-rabbits-in-space.html https://www.nasa.gov/audience/forstudents/9-12/features/F_Animals_in_Space_9-12.html https://en.wikipedia.org/wiki/Animals_in_space http://www.china.org.cn/top10/2011-11/22/content_23976223_7.htm Word of the Week: Precaution Plant of the Week: Rhubarb Story of the Week: Rabbit and the Moon Man http://www.native-languages.org/mikmaqstory3.htm This is a Mi'kmaq Native American Tale The Mi'kmaq Nation is a member of the Wabanaki Confederacy that controlled northern New England and the Canadian Maritimes. The Micmacs are original natives of the Nova Scotia/New Brunswick region. They also settled in locations in Quebec, Newfoundland, and Maine. Today, most Mi'kmaq people live on the Canadian side of the border, but the Aroostook Micmacs live in northeastern Maine. Long ago, Rabbit was a great hunter. He lived with his grandmother in a lodge which stood deep in the Micmac forest. It was winter and Rabbit set traps and laid snares to catch game for food. He caught many small animals and birds, until one day he discovered that some mysterious being was robbing his traps. Rabbit and his grandmother became hungry. Though he visited his traps very early each morning, he always found them empty. At first Rabbit thought that the robber might be a cunning wolverine, until one morning he found long, narrow footprints alongside his trap line. It was, he thought, the tracks of the robber, but they looked like moonbeams. Each morning Rabbit rose earlier and earlier, but the being of the long foot was always ahead of him and always his traps were empty. Rabbit made a trap from a bowstring with the loop so cleverly fastened that he felt certain that he would catch the robber when it came. He took one end of the thong with him and hid himself behind a clump of bushes from which he could watch his snare. It was bright moonlight while he waited, but suddenly it became very dark as the moon disappeared. A few stars were still shining and there were no clouds in the sky, so Rabbit wondered what had happened to the moon. Someone or something came stealthily through the trees and then Rabbit was almost blinded by a flash of bright, white light which went straight to his trap line and shone through the snare which he had set. Quick as a lightning flash, Rabbit jerked the bowstring and tightened the noose. There was a sound of struggling and the light lurched from side to side. Rabbit knew b the tugging on his string that he had caught the robber. He fastened the bowstring to a nearby sapling to hold the loop tight. Rabbit raced back to tell his grandmother, who was a wise old woman, what had happened. She told him that he must return at once and see who or what he had caught. Rabbit, who was very frightened, wanted to wait for daylight but his grandmother said that might be too late, so he returned to his trap line. When he came near his traps, Rabbit saw that the bright light was still there. It was so bright that it hurt his eyes. He bathed them in the icy water of a nearby brook, but still they smarted. He made big snowballs and threw them at the light, in the hope of putting it out. As they went close to the light, he heard them sizzle and saw them melt. Next, Rabbit scooped up great pawfuls of soft clay from the stream and made many big clay balls. He was a good shot and threw the balls with all of his force at the dancing white light. He heard them strike hard and then his prisoner shouted. Then a strange, quivering voice asked why he had been snared and demanded that he be set free at once, because he was the man in the moon and he must be home before dawn came. His face had been spotted with clay and, when Rabbit went closer, the moon man saw him and threatened to kill him and all of his tribe if he were not released at once. Rabbit was so terrified that he raced back to tell his grandmother about his strange captive. She too was much afraid and told Rabbit to return and release the thief immediately. Rabbit went back, and his voice shook with fear as he told the man in the moon that he would be released if he promised never to rob the snares again. To make doubly sure, Rabbit asked him to promise that he would never return to earth, and the moon man swore that he would never do so. Rabbit could hardly see in the dazzling light, but at last he managed to gnaw through the bowstring with his teeth and the man in the moon soon disappeared in the sky, leaving a bright trail of light behind him. Rabbit had been nearly blinded by the great light and his shoulders were badly scorched. Even today, rabbits blink as though light is too strong for their eyes; their eyelids are pink, and their eyes water if they look at a bright light. Their lips quiver, telling of Rabbit's terror. The man in the moon has never returned to earth. When he lights the world, one can still see the marks of the clay which Rabbit threw on his face. Sometimes he disappears for a few nights, when he is trying to rub the marks of the clay balls from his face. Then the world is dark; but when the man in the moon appears again, one can see that he has never been able to clean the clay marks from his shining face. News stories of the Week:  2-4-17 Forty-foot Peter Rabbit statue built to mark Beatrix Potter’s 150th anniversary burnt down in suspected arson.  A 40ft straw statue of Peter Rabbit built for Beatrix Potter’s 150th anniversary has been burnt down in a suspected arson attack.  The tribute to the children's book character was unveiled last year to mark the anniversary of the Lake District writer's birth.  Police and fire chiefs are investigating the cause of the blaze that destroyed the artwork in a Cheshire field, But now there is nothing left after it caught fire at around 5pm on Thursday, in its field at Snugburys farm in Hurleston, Cheshire.  "It's wonderful to see that Peter Rabbit was loved by so many.  We certainly won't let this stop us!"family that run Snugburys farm.  For more than 10 years, staff at Snugburys have been building sculptures in their field. The giant Peter Rabbit was made last summer.  The farm wrote on its website: "The whole Snugburys family grew up listening to the stories of Peter and his friends.  "They therefore felt it was only fitting to dedicate this year's straw sculpture to Beatrix Potter. In total around 1,000 man hours have been spent creating the feature.  "The inspiration for the blue jacket came from recycling the blue bags our packaging arrives in.  We hand wove a thin layer of blue bags over the straw and we are really pleased with the outcome.  "The whole structure weighs in at an impressive 8 tonnes and Peter stands at 38 ft tall, with his 10 ft carrot and 10 ft ears!".  In a statement, the farm said: "We are very sad to confirm Peter was set alight last night by an arsonist.  "Thank you all - we are truly overwhelmed by all the support from everyone far and wide in the last few hours.  "It's wonderful to see that Peter Rabbit was loved by so many. We certainly won't let this stop us!"  Cheshire Fire and Rescue Service confirmed a crew from Nantwich was sent to the scene. Fire investigators are now liaising with Cheshire Police into the case of the incident. http://www.telegraph.co.uk/news/2017/02/03/forty-footpeter-rabbit-statue-built-markbeatrix-potters-150th/ Where top rabbit keepers go for lessons Neat cages made of timber and stainless weldmesh hosting dozens of animals welcome one to the Ngong National Rabbit Breeding Centre.  Successful rabbit farming depends on three things, first is the right structures in terms of houses, cages and pens. Two, a good feeding regime from when the animals are young to maturity and three, prevention and control of diseases,” says Vincent Maritim, the Deputy Officer in-charge of the centre. The article goes on to discussed housing, feeding and suggested meat breeds. Rabbit Keeping on the Rise There are no payments or registration for farmers when they visit the Ngong Rabbit Centre. Payment is made when there is training, where they part with Sh2,500 for three days.  “This is a breeding and training centre. We train farmers on how to raise rabbits and how to go commercial with rabbit farming. The training should be free, but there are costs that have to be incurred like lunch and stationery,” says Vincent Maritim, the deputy officer at the centre.  They sell rabbits to farmers who come for the breeding stock. They include individuals, institutions, farmers’ associations and farmers from neighbouring countries like Tanzania as well.  “Most farmers buy our rabbits for breeding. We only sell the non-productive rabbits for eating to farmers. We sell weaners at Sh750 and three-month olds at Sh1,500.”  Rabbit farming is fast spreading in the country due to its vast potential and ease of management.  The increasing cost of beef, mutton and poultry have motivated many farmers to rearing rabbits, which they slaughter themselves.  The meat is also sought in niche market http://www.nation.co.ke/business/seedsofgold/Where-top-rabbit-keepers-go-for-lessons/2301238-3798512-4ogggtz/ Del. Fariss' tall tale of rabbit hunt brings down the House Del. C. Matthew Fariss, R-Campbell, brought down the House (of Delegates) on Friday as he spun a tall tale of a bipartisan rabbit hunt on the grounds of the state Capitol.  The House gave preliminary approval to House Bill 1900, sponsored by Speaker of the House William J. Howell, R-Stafford, in spite of Fariss’ yarn in opposition to the bill. The bill would set civil penalties for people who knowingly and without permission let their hunting dogs roam over landowners’ property after notice is given. http://www.richmond.com/news/virginia/government-politics/article_516d81af-5c64-5220-a76f-1c2afd7b421b.html Snaring plan for Carmanville rabbit problem called off The central Newfoundland town of Carmanville has abandoned a plan to snare wild rabbits that are overrunning their community.  Wildlife officers will no longer be setting up rabbit snares next week, in response to the rabbit problem plaguing the town.  The town posted on Facebook Friday night that another plan would be developed.  The problem began about 10 years ago when someone's pet rabbits escaped and started breeding outside with other wild animals.  In recent years, the numbers have escalated to the point where residents in the Carmanville area are regularly complaining about their gardens being destroyed.  However just hours after the town posted the notice about the snaring, another notice was posted saying the plan had been abandoned and that "alternate solutions" would be explored http://www.cbc.ca/news/canada/newfoundland-labrador/carmanville-rabbit-problem-1.3966159 Belmont bunny predicts 6 more weeks of winter BELMONT - The rabbits of Belmont Community Day Care sought to continue their three-year streak of showing up groundhogs when it comes to predicting the duration of winter.  "We decided to cheat off of Groundhog Day and have Hare Hog Day, because we aren't allowed to have groundhogs," says Richard Doren, the day care's executive director.  The Belmont bunny Carmel set out to see its shadow -- or not -- much like the famous groundhog Punxsutawney Phil http://bronx.news12.com/news/carmel-the-rabbit-of-belmont-community-day-care-predicts-6-more-weeks-of-winter-on-groundhog-day-1.13056506 Rabbits, large and small, strut their fluff at Stock Show Exhibitors showed nearly 800 rabbits, representing 28 different breeds, on Saturday. There were Californians and New Zealands, prized for their meat; Lionheads, named for the distinct wool mane around their head; and Checkered Giants, known for their black and white fur and large stature.  Rabbit show Superintendent Tom Bell said judges evaluate rabbits by a number of qualities, from the sheen of their fur to arch of their back.  “Everything depends on the breed, and no two rabbits are identical,” said Bell, who has raised and shown rabbits since 1980 Read more here: http://www.star-telegram.com/news/local/community/fort-worth/fw-stock-show/article129358299.html#storylink=cpy Brave rabbit fends off a falcon in a showdown for the ages The wild is a scary place, but unlikely heroes emerge as a result.  In this video posted on Youtube by user DUB TV, a rabbit combats an attack from an aggressive falcon in a dramatic fight of life and death.  Even though the falcon has height on its side, the scrappy hare puts its dukes up and shows the falcon who's boss.  For now, this rabbit reigns on as King of the Prairie. http://mashable.com/2017/02/02/rabbit-fends-off-falcon/#o8RQ5O9_Vaqa 'Thousands' of feral bunny rabbits run rampant in Las Vegas communities Pet bunnies might seem like a good idea but many end up dumped in the wild, becoming feral. The abandoned household pets are now multiplying and taking over communities across the Las Vegas Valley.  Animal advocates estimate there could be thousands of feral bunnies throughout the community. Although it's not clear how the dumping sites started, the problem is only getting worse. http://news3lv.com/news/local/thousands-of-feral-bunny-rabbits-run-rampant-in-las-vegas-communities Thief dressed in bunny onesie steals hundreds worth of supplies from Jacksonville nail salon by: Amber Krycka, Action News Jax Updated: Feb 2, 2017 - 8:23 PM JACKSONVILLE, Fla. - A local business owner is trying to find the person who broke into his nail salon dressed in a onesie.  This week, Kenny Do, with China Nails in North Jacksonville, said someone shattered his front door, crawled inside and stole more than $500 worth of nail supplies. The entire crime was caught on surveillance video.  Dressed in a bunny-like onesie, the thief wastes no time. He smashes the glass door, crawls in and quickly grabs as many items as possible.  But this bunny snatcher wasn’t after money. He passed the cash register and went straight for the nail supplies. http://www.actionnewsjax.com/news/local/thief-dressed-in-bunny-onesie-steals-hundreds-worth-of-supplies-from-jacksonville-nail-salon/490421663

Flt3 is the most recently discovered member of the platelet-derived growth factor receptor (PDGFR) subfamily of receptor tyrosine kinases (RTKs). It is expressed on early hematopoietic progenitor cells and is involved in their growth. Activating mutations of Flt3, such as internal tandem duplications (ITD) in the juxtamembrane (JM) region of Flt3, are among the most common genetic alterations found in patients with acute myeloid leukemia (AML). For this reason Flt3 is an attractive target for specific tyrosine kinase inhibitors, and a number of such compounds are currently being tested in clinical trials. However, the mechanisms of Flt3-mediated signal transduction are poorly understood. Src family tyrosine kinases (SFKs) are involved in the signaling processes of various RTKs, including those of the PDGFR subfamily . Most SFKs are expressed predominantly or exclusively in hematopoietic cells, and at least Hck and Lyn were found to be activated in AML patients. These observations indicate that SFKs could also be involved in Flt3 signaling. In this work the role of SFKs in signal transduction of the Flt3 receptor was investigated. A panel of Hck and Flt3 mutants was used in biochemical and biological assays to deduce the contribution of kinase activity, SH2 and SH3 binding domains and tyrosine phosphorylation status to Flt3-SFK interaction. The work presented shows that SFKs interfere with the maturation of wild type and Flt3 ITD receptors in human embryonic kidney 293 (HEK- 293) cells in a kinase-dependent manner. The SFK-mediated effect on receptor maturation is reflected by accumulation of the immature, intracellular form of Flt3 at the expense of the mature, plasma membrane-inserted form of the receptor. This effect of SFK kinase activity on receptor maturation is not limited to Flt3, because analogous results were also obtained for the Kit receptor, another member of the PDGFR subfamily. The demonstration of the role of SFKs in regulation of receptor maturation is novel and the exact mechanism underlying this effect requires further investigation. Using the HEK-293 cells it was also shown that Hck is able to phosphorylate Flt3 on tyrosine residues and to associate with autophosphorylated Flt3 in an SH2 domain-dependent manner. Hck-mediated tyrosine phosphorylation occurs in the JM region of Flt3. Tyrosine residues 589 and 591 in the JM region, when phosphorylated, were also identified as the docking sites for Hck. Although Hck phosphorylation and binding sites on Flt3 overlap, Hck-mediated phosphorylation of Flt3 is not sufficient for Flt3-Hck association. In contrast to the situation in HEK-293 cells, Hck neither interferes with Flt3 maturation nor phosphorylates Flt3 on tyrosine residues, and does not detectably associate with the Flt3 receptor in the hematopoietic murine cell line 32D clone 3 (32D cl.3). However, the level of the ectopic expression of Hck in 32D cl.3 cells was lower than in HEK-293 cells. This difference in Hck expression level probably accounts for both the lack of the Hck-mediated phosphorylation of Flt3 and the interference with its maturation in 32D cl.3 cells. The lower Hck expression level, however, does not account for the lack of detectable association of Hck with Flt3 in 32D cl.3 cells. Using biological assays in which activation of Flt3 can partially overcome the requirement for cytokine stimulation in 32D cl.3 survival and proliferation, it was shown that Hck is not involved in Flt3 signal transduction leading to Flt3-mediated cell survival and Flt3 ITD-dependent cell growth. Therefore, biological relevance of SFKs in Flt3 signaling remains unclear. In summary, although the binding and phosphorylation of Flt3 by Hck can be shown, the biological relevance of Hck in Flt3 signaling remains to be formally demonstrated. This research led to the novel finding that, at least when over-expressed or hyperactivated, SFKs interfere with the maturation process of RTKs. Various studies have shown that the ligandindependent activation of RTKs as well as their premature phosphorylation can interfere with maturation of RTKs. This study reveals that, by virtue of their phosphorylating of Flt3, Kit and possibly other RTKs, SFKs can regulate maturation of these RTKs and consequently alter their transport to the plasma membrane. Further studies are required to investigate the biological relevance of this function of SFKs.