Podcasts about erythrocyte

Objective: Determine the significance and clinical use of Erythrocyte Sedimentation Rate in clinical practice   Lab Test Name: Erythrocyte Sedimentation Rate- ESR   Description: The Erythrocyte Sedimentation Rate (ESR) test measures sedimentation of Red Blood Cells (RBCs).  In normal conditions, RBCs settle or sediment very little.  Inflammation affects proteins in the blood causing RBCs to stick and settle together out of the liquid portion of the blood.   Indications: Identifies inflammation which assists in diagnosing: Cancer Infection Autoimmune diseases   Normal Therapeutic Values: Normal – 0-20 mm/hr   What would cause increased levels? Increased Conditions: Anemia Chronic Renal Failure Systemic Lupus Erythematosus (SLE) Infection Tuberculosis Pregnancy Polymyalgia Rheumatica Multiple myeloma Medications: Oral contraceptives Theophylline Vitamin A   What would cause decreased levels? Decreased Conditions: Sickle cell anemia Polycythemia Vera Leukocytosis Congestive Heart Failure (CHF) Medications: Aspirin Cortisone Quinine

Erythrocytopenia, leukocytopenia, leukopenia, osteopenia  these are some of the terms you will come across in your Funeral Service Pathology class.  I think it's a good idea to study the prefixes and suffixes of medical terms as they tend to repeat themselves. Here we see penia as in cytopenia, leukopenia.  Penia was the Greek Goddess of Poverty.  Her role was to teach humans to be productive and humble. To me the Penia sounds a lot like penny so it's an easy connection.  Therefore, anything-penia is a deficiency in something.  Here's an example Erythrocytopenia, Erythrocyte is a red blood cell add penia to that and you have a deficiency of red blood cells.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.16.528793v1?rss=1 Authors: Kepple, D., Ford, C. T., Williams, J., Abagero, B., Li, S., Popovici, J., Yewhalaw, D., Lo, E. Abstract: Plasmodium vivax uses Duffy binding protein (PvDBP1) to bind to the Duffy Antigen-Chemokine Receptor (DARC) to invade human erythrocytes. Individuals who lack DARC expression (Duffy-negative) are thought to be resistance to P. vivax. In recent years, P. vivax malaria is becoming more prevalent in Africa with a portion of these cases detected in Duffy-negatives. Apart from DBP1, members of the reticulocyte binding protein (RBP) and tryptophan-rich antigen (TRAg) families may also play a role in erythrocyte invasion. While the transcriptomes of the Southeast Asian and South American P. vivax are well documented, the gene expression profile of P. vivax in Africa and more specifically the expression level of several erythrocyte binding gene candidates as compared to DBP1 are largely unknown. This paper characterized the first P. vivax transcriptome in Africa and compared with those from the Southeast Asian and South American isolates. The expression of 4,404 gene transcripts belong to 12 functional groups including 43 specific erythrocyte binding gene candidates were examined. Overall, there were 10-26% differences in the gene expression profile amongst the geographical isolates, with the Ethiopian and Cambodian P. vivax being most similar. Majority of the gene transcripts involved in protein transportation, housekeeping, and host interaction were highly transcribed in the Ethiopian P. vivax. Erythrocyte binding genes including PvRBP2a and PvRBP3 expressed six-fold higher than PvDBP1and 60-fold higher than PvEBP/DBP2. Other genes including PvRBP1a, PvMSP3.8, PvMSP3.9, PvTRAG2, PvTRAG14, and PvTRAG22 also showed relatively high expression. Differential expression was observed among geographical isolates, e.g., PvDBP1 and PvEBP/DBP2 were highly expressed in the Cambodian but not the Brazilian and Ethiopian isolates, whereas PvRBP2a and PvRBP2b showed higher expression in the Ethiopian and Cambodian than the Brazilian isolates. Compared to Pvs25, the standard biomarker for detecting female gametocytes, PvAP2-G (PVP01_1440800), GAP (PVP01_1403000), and Pvs47 (PVP01_1208000) were highly expressed across geographical samples. These findings provide an important baseline for future comparisons of P. vivax transcriptomes from Duffy-negative infections and highlight potential biomarkers for improved gametocyte detection. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Podcast Editor, Erin Quist, interviews author Erica Behling-Kelly to discuss the article, "Identifying Erythrocyte Injury in Toxicology Studies" which can currently be found in Volume 50, Issue 7 of Toxicologic Pathology. Click here to read the article

Get a free nursing lab values cheat sheet at NURSING.com/63labs   Objective: Determine the significance and clinical use of Erythrocyte Sedimentation Rate in clinical practice   Lab Test Name: Erythrocyte Sedimentation Rate- ESR   Description: The Erythrocyte Sedimentation Rate (ESR) test measures sedimentation of Red Blood Cells (RBCs).  In normal conditions, RBCs settle or sediment very little.  Inflammation affects proteins in the blood causing RBCs to stick and settle together out of the liquid portion of the blood.   Indications: Identifies inflammation which assists in diagnosing: Cancer Infection Autoimmune diseases   Normal Therapeutic Values: Normal – 0-20 mm/hr   What would cause increased levels? Increased Conditions: Anemia Chronic Renal Failure Systemic Lupus Erythematosus (SLE) Infection Tuberculosis Pregnancy Polymyalgia Rheumatica Multiple myeloma Medications: Oral contraceptives Theophylline Vitamin A   What would cause decreased levels? Decreased Conditions: Sickle cell anemia Polycythemia Vera Leukocytosis Congestive Heart Failure (CHF) Medications: Aspirin Cortisone Quinine

“Microtoons” played to rave reviews at the May 2022 ANIMATION Film Festival. “What starts as a normal day for Eric the Erythrocyte becomes an action-packed adventure as the Golden Staph Gang invades the body and battles with the white blood cell army. As the general leading the army, Mike the Macrophage finds himself caught between leading the battle and keeping Eric out of harm's way. MicroToons entertains and explores the science of the microbiological world with original characters.” Conversation with collaborators Aaron Welch & Rina Fu on the making of the film from the day they met to distribution. Project Links: http://www.redbirdcreative.com.au/ https://www.facebook.com/RedBirdCreative https://twitter.com/scientist_mum https://www.instagram.com/redbirdcreative/ Film played on the WILDsound TV app next month. You can sign up for the 7 day free trial at www.wildsound.ca (available on your streaming services and APPS). There is a DAILY film festival to watch, plus a selection of award winning films on the platform. Then it's only $3.99 per month. Subscribe to the podcast: https://twitter.com/wildsoundpod https://www.instagram.com/wildsoundpod/ https://www.facebook.com/wildsoundpod

Curso TdC de Pronto Atendimento - Inscrições abertas: https://cursotdc.com.br/pagina-de-vendas/ Cupom desconto: TDC300 Nesse episódio, Fred, Iago e Ênio debatem sobre as principais evidências (e da falta delas) para o uso da VHS, PCR e Procalcitonina! Referências: Dima A, Opris D, Jurcut C, Baicus C. Is there still a place for erythrocyte sedimentation rate and C-reactive protein in systemic lupus erythematosus?. Lupus. 2016 Oct;25(11):1173-9. Brigden ML. Clinical utility of the erythrocyte sedimentation rate. American family physician. 1999 Oct 1;60(5):1443-50. Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, Yale SH. Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine. Wmj. 2016 Dec;115(6):317-21. Jurado RL. Why shouldn't we determine the erythrocyte sedimentation rate?. Clinical infectious diseases. 2001 Aug 15;33(4):548-9. Malcolm Brigden MD (1998) The erythrocyte sedimentation rate, Postgraduate Medicine, 103:5, 257-274 Watson J, Jones HE, Banks J, Whiting P, Salisbury C, Hamilton W. Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy. British journal of general practice. 2019 Jul 1;69(684):e462-9. Batlivala SP. Focus on DiagnosisThe Erythrocyte Sedimentation Rate and the C-reactive Protein Test. Pediatrics in Review. 2009 Feb 1;30(2):72-4. Acute phase reactantes. Acesso em uptodate.com Boere, Tjarda M., et al. "Effect of C reactive protein point-of-care testing on antibiotic prescribing for lower respiratory tract infections in nursing home residents: cluster randomised controlled trial." bmj 374 (2021). Santonocito, Cristina, et al. "C-reactive protein kinetics after major surgery." Anesthesia & Analgesia 119.3 (2014): 624-629. Cals, Jochen WL, et al. "Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial." Bmj 338 (2009). Butler, Christopher C., et al. "C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations." New England Journal of Medicine 381.2 (2019): 111-120. Llor, Carl, et al. "Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease." American journal of respiratory and critical care medicine 186.8 (2012): 716-723. Straatman, Jennifer, et al. "Predictive value of C-reactive protein for major complications after major abdominal surgery: a systematic review and pooled-analysis." PloS one 10.7 (2015): e0132995. Plat, Victor D., et al. "C-reactive protein after major abdominal surgery in daily practice." Surgery 170.4 (2021): 1131-1139. Kang, Byung-Uk, et al. "Surgical site infection in spinal surgery: detection and management based on serial C-reactive protein measurements." Journal of Neurosurgery: Spine 13.2 (2010): 158-164. Andreeva, Elena, and Hasse Melbye. "Usefulness of C-reactive protein testing in acute cough/respiratory tract infection: an open cluster-randomized clinical trial with C-reactive protein testing in the intervention group." BMC family practice 15.1 (2014): 1-9. Prins, H. J., et al. "CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions." European Respiratory Journal 53.5 (2019).

In this episode, we review the high-yield topic of Erythrocyte Sedimentation Rate from the Pathology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficialx Twitter: www.twitter.com/medbulletsIn this episode --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

It would be hard to find any health practitioner - traditional, functional, or otherwise - who doesn’t acknowledge the importance of consuming omega-3 fatty acids. Supplements in the form of fish oil or krill oil are widely recommended and consumed, and come with claims of cardiovascular disease prevention, cognitive benefits, and anti-inflammatory properties. But is it really a good idea to get your omega-3s in a gel cap rather than from food? And do they really do everything the media would have you believe? On this podcast, NBT Scientific Director Megan Hall and I discuss omega-3 fatty acids: what they are, what they’re good for, and the best ways to get them. Megan outlines the different types of omega-3 and explains why some are better than others. She also explains why some health claims are overblown, and why buying fish oil supplements may not be the best health strategy. Be sure to follow along with Megan’s outline for this podcast.  Here’s the outline of this interview with Megan Hall: [00:04:30] Blood flow restriction (BFR) training; Podcast: Blood Flow Restriction Training for Improved Strength, Performance, and Healthspan with Dr Jim Stray-Gundersen MD. [00:04:51] Podcast: Wired to Run: Why Your Brain Needs Exercise, David Raichlen. [00:05:41] What are omega-3 fatty acids? [00:06:31] Picture of omega-3 fatty acids. [00:08:40] Finding omega-3s in the diet; Review: Saini, Ramesh Kumar, and Young-Soo Keum. "Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance—A review." Life sciences 203 (2018): 255-267. [00:09:16] Poor conversion from ALA to EPA/DHA: Gerster, Helga. "Can adults adequately convert a-linolenic acid (18: 3n-3) to eicosapentaenoic acid (20: 5n-3) and docosahexaenoic acid (22: 6n-3)?." International journal for vitamin and nutrition research 68.3 (1998): 159-173. [00:10:56] Why EPA and DHA are important. [00:11:38] Conditions associated with inadequate omega-3 intake. [00:12:02] Whole foods vs. supplements; other micronutrients. [00:12:42] Krill oil vs. fish oil; Studies: 1. Ulven, Stine M., et al. "Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers." Lipids 46.1 (2011): 37-46. 2. Schuchardt, Jan Philipp, et al. "Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations-a comparative bioavailability study of fish oil vs. krill oil." Lipids in health and disease 10.1 (2011): 1-7. 3. Maki, Kevin C., et al. "Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women." Nutrition research 29.9 (2009): 609-615. 4. Mödinger, Yvonne, et al. "Plasma kinetics of choline and choline metabolites after a single dose of SuperbaBoostTM krill oil or choline bitartrate in healthy volunteers." Nutrients 11.10 (2019): 2548. [00:16:59] Megan's outline for this podcast. [00:18:21] Algae-based omega-3 supplements. [00:19:40] Omega 6:3 ratio; Paper: Simopoulos, Artemis P. "The importance of the ratio of omega-6/omega-3 essential fatty acids." Biomedicine & pharmacotherapy 56.8 (2002): 365-379. [00:25:54] Should we be supplementing with grams of fish oil? Studies: 1. De Magalhães, João Pedro, et al. "Fish oil supplements, longevity and aging." Aging (Albany NY) 8.8 (2016): 1578. 2. Strong, Randy, et al. "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer." Aging cell 15.5 (2016): 872-884. 3. López-Domínguez, José A., et al. "The influence of dietary fat source on life span in calorie restricted mice." Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 70.10 (2015): 1181-1188. [00:27:42] No support for omega-3 (fish oil) in the prevention of cardiovascular disease; Meta-analysis: Aung, Theingi, et al. "Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77 917 individuals." JAMA cardiology 3.3 (2018): 225-233. [00:29:12] Signs you're supplementing too much fish oil. [00:30:26] Podcast: How Oxidative Stress Impacts Performance and Healthspan [00:30:43] Elevated blood glucose omega-3 supplementation; Study: Friday, Karen E., et al. "Elevated plasma glucose and lowered triglyceride levels from omega-3 fatty acid supplementation in type II diabetes." Diabetes care 12.4 (1989): 276-281. [00:31:01] Immunosuppressive effects of supplementing omega-3s: Fenton, Jenifer I., et al. "Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes." Prostaglandins, Leukotrienes and Essential Fatty Acids 89.6 (2013): 379-390. [00:34:17] Stages of life when omega-3s are especially important. [00:34:48] Specialized pro-resolving mediators; STEM Talk podcast episode: David LeMay Talks About Countering Inflammation with SPMS. [00:35:31] DHA to mitigate traumatic brain injury; Study: Bailes, Julian E., and Vimal Patel. "The potential for DHA to mitigate mild traumatic brain injury." Military medicine 179.suppl_11 (2014): 112-116. [00:35:45] DHA for cognitive function and aging; Study: Weiser, Michael J., Christopher M. Butt, and M. Hasan Mohajeri. "Docosahexaenoic acid and cognition throughout the lifespan." Nutrients 8.2 (2016): 99. [00:37:20] omega-3s for athletic performance; Review: Gammone, Maria Alessandra, et al. "Omega-3 polyunsaturated fatty acids: benefits and endpoints in sport." Nutrients 11.1 (2019): 46. [00:38:54] omega-3s during pregnancy; Studies: Greenberg, James A., Stacey J. Bell, and Wendy Van Ausdal. "Omega-3 fatty acid supplementation during pregnancy." Reviews in obstetrics and Gynecology 1.4 (2008): 162; 2. Braarud, Hanne Cecilie, et al. "Maternal DHA status during pregnancy has a positive impact on infant problem solving: a Norwegian prospective observation study." Nutrients 10.5 (2018): 529. [00:39:44] Excess omega-3 consumption during pregnancy could be detrimental to offspring; Study: Church, M. W., et al. "Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring." Neurotoxicology and teratology 32.2 (2010): 171-181. [00:40:12] Testing: The Omega Index test; Framingham Heart Study: Harris, William S., et al. "Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study." Journal of clinical lipidology 12.3 (2018): 718-727. [00:42:34] Bottom line: More may not be better. [00:43:09] SMASH fish - sardines, mackerel, anchovies, salmon, herring (also black cod), 3-4x/week. [00:49:30] Schedule a free 15 min call with Megan.

This episode covers erythrocyte pathologies!

This episode covers pathologic erythrocyte forms!

FDA 批准治疗Cushing综合征的新药BMJ 妊娠期糖尿病患者16年后的2型糖尿病患病率比对照组高8.5倍Science Advance 可监测血糖、治疗糖网的隐形眼镜奥西卓司他（osilodrostat）奥西卓司他（osilodrostat）是一种新型的口服11‐β‐羟化酶和醛固酮合成酶抑制剂，可以直接阻断肾上腺皮质醇合成。2020年3月，FDA批准奥西卓司他上市，用于治疗库欣综合征，这是FDA批准的首个口服11‐β‐羟化酶抑制剂。《LINC3研究：奥西卓司他治疗库欣氏病的多中心、双盲、随机停药的III期临床试验》Lancet Diabetes Endocrinology，2020年8月 (1)LINC 3研究是一项前瞻性、多中心、开放标签、III期研究，旨在研究奥西卓司对库欣氏病治疗的安全性和有效性。研究共入组137人（平均年龄41岁、3/4为女性、未接受过垂体切除手术或接受过垂体切除手术但未治愈、24小时皮质醇>1.5*ULN）。研究采用双盲随机停药，包括四个期：（1）所有参与者服用开放标签的奥西卓司他直到第12周，每2周调整一次剂量直至30mg bid；（2）第13-24周，继续使用奥西卓司他；（3）26周开始，双盲、随机停药8周；（4）35-48周，所有患者开放标签的奥西卓司他直到研究结束。研究发现在，第34周，与随机停药组29%的患者相比，随机服药组86%的患者保持完全缓解状态。137例患者在第12周后完全缓解，滴度没有上升。结论：每天两次奥西卓司快速降低了平均24小时皮质醇浓度，同时改善了临床症状。2型糖尿病的预防2型糖尿病的高危人群包括：年龄≥45岁，有妊娠期糖尿病病史，BMI≥25kg/m2，一级亲属有糖尿病，久坐的生活方式，高血压高血脂。预防糖尿病的发生主要通过：锻炼和减重，戒烟或服用二甲双胍。其他用于预防的糖尿病的药，如利拉鲁肽、比格列酮、阿卡波糖、维生素D等，尚有争议。《荟萃分析：维生素D对糖尿病发病率的影响》Journal of Clinical Endocrinology and Metabolism，2020年8月 (2)这项荟萃分析的目的是平均25-羟基维生素D（25[OH]D）血液水平低与胰岛素分泌受损、胰岛素抵抗增加和2型糖尿病发病率增加相关。研究者对9项随机对照试验进行了荟萃分析，涵盖43,600名参与者，随访至少一年。在接受较大剂量维生素D（≥1000IU/d）的、糖尿病前期的、人群中，2型糖尿病的发病率较低（相对风险比 0.88），这一结果勉强达到统计学显著性。在接受较小剂量维生素D（

FDA 批准治疗Cushing综合征的新药BMJ 妊娠期糖尿病患者16年后的2型糖尿病患病率比对照组高8.5倍Science Advance 可监测血糖、治疗糖网的隐形眼镜奥西卓司他（osilodrostat）奥西卓司他（osilodrostat）是一种新型的口服11‐β‐羟化酶和醛固酮合成酶抑制剂，可以直接阻断肾上腺皮质醇合成。2020年3月，FDA批准奥西卓司他上市，用于治疗库欣综合征，这是FDA批准的首个口服11‐β‐羟化酶抑制剂。《LINC3研究：奥西卓司他治疗库欣氏病的多中心、双盲、随机停药的III期临床试验》Lancet Diabetes Endocrinology，2020年8月 (1)LINC 3研究是一项前瞻性、多中心、开放标签、III期研究，旨在研究奥西卓司对库欣氏病治疗的安全性和有效性。研究共入组137人（平均年龄41岁、3/4为女性、未接受过垂体切除手术或接受过垂体切除手术但未治愈、24小时皮质醇>1.5*ULN）。研究采用双盲随机停药，包括四个期：（1）所有参与者服用开放标签的奥西卓司他直到第12周，每2周调整一次剂量直至30mg bid；（2）第13-24周，继续使用奥西卓司他；（3）26周开始，双盲、随机停药8周；（4）35-48周，所有患者开放标签的奥西卓司他直到研究结束。研究发现在，第34周，与随机停药组29%的患者相比，随机服药组86%的患者保持完全缓解状态。137例患者在第12周后完全缓解，滴度没有上升。结论：每天两次奥西卓司快速降低了平均24小时皮质醇浓度，同时改善了临床症状。2型糖尿病的预防2型糖尿病的高危人群包括：年龄≥45岁，有妊娠期糖尿病病史，BMI≥25kg/m2，一级亲属有糖尿病，久坐的生活方式，高血压高血脂。预防糖尿病的发生主要通过：锻炼和减重，戒烟或服用二甲双胍。其他用于预防的糖尿病的药，如利拉鲁肽、比格列酮、阿卡波糖、维生素D等，尚有争议。《荟萃分析：维生素D对糖尿病发病率的影响》Journal of Clinical Endocrinology and Metabolism，2020年8月 (2)这项荟萃分析的目的是平均25-羟基维生素D（25[OH]D）血液水平低与胰岛素分泌受损、胰岛素抵抗增加和2型糖尿病发病率增加相关。研究者对9项随机对照试验进行了荟萃分析，涵盖43,600名参与者，随访至少一年。在接受较大剂量维生素D（≥1000IU/d）的、糖尿病前期的、人群中，2型糖尿病的发病率较低（相对风险比 0.88），这一结果勉强达到统计学显著性。在接受较小剂量维生素D（

Dear Listeners, The C-Reactive Protein and the Erythrocyte Sedimentation Rate are both lab tests used to measure inflammation in the body. They are usually elevated during infectious, inflammatory, and malignant diseases.  The CRP is produced by the liver shortly after the offending process so it is a direct measure of inflammation. The ESR is based […] The post Podcast 69: C-Reactive Protein and Erythrocyte Sedimentation Rate appeared first on Primary Medicine Podcast.

The Latest Malaria News, in 60 Seconds. Scientists publish new insights into Plasmodium falciparum P2, and the IDDO launch an online tool to map the prevalence of substandard and falsified antimalarial drugs around the world. More: www.fightmalaria.uk/MalariaMinute

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.29.225839v1?rss=1 Authors: Miller, J., Odom John, A. R. Abstract: Infection with malarial parasites renders hosts more mosquito attractive than their uninfected, healthy, counterparts. One volatile organic compound, -pinene, is associated with Plasmodium spp. infection in multiple studies and is a known mosquito attractant. However, how malarial infection results in elevated levels of host-associated -pinene remains unclear. One study suggests that erythrocyte exposure to the malarial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), results in increased levels of -pinene. Here, we establish that endogenous levels of -pinene are present in human erythrocytes, that these levels vary widely by erythrocyte donor, and that -pinene levels are not altered by HMBPP treatment. Copy rights belong to original authors. Visit the link for more info

Finally, a way to read comics in class without your teacher complaining! Real life scientists are producing educational comics to teach cool science stuff. And they're FREE! Check them out, they have some pretty good explanations for a bunch of different topics.The FDA has recognised the ability of video games to help with therapy and greenlit a game for treating ADHD suffers. I can't wait for a game to help you deal with idiots, but we'll get there one day.Where did Matt Mercer's Vox Machina come from? Now you can read both of the first two seasons of the Critical Role prequels in a hardback omnibus. Wait, didn't we already do comics this week? Oops. Anyway, watch Critical Role. It's really good.This week, Professor took to the skies in Sky Rogue and DJ set us up the bomb in Valorant.Real Life Scientists making comics- https://www.sciencenews.org/article/real-life-scientists-inspire-comic-book-superheroes-science-literacy- https://www.jkxcomics.com/- https://static1.squarespace.com/static/59ab7c15e4fcb5c602a09465/t/5a08e052e2c483d6cb8cf769/1510531187492/JKXComics_EBV+and+the+Replication+Dance.pdfA video game for kids with ADHD is greenlit by the FDA- https://www.statnews.com/2020/06/15/fda-akili-adhd-endeavorrx/Dark Horse to Release 'Critical Role' Hardcover Omnibus- https://www.hollywoodreporter.com/heat-vision/dark-horse-release-critical-role-hardcover-omnibus-1296484Games PlayedProfessor– Sky Rogue - https://store.steampowered.com/app/381020/Sky_Rogue/Rating: 3.5/5DJ– Valorant – https://playvalorant.com/en-us/Rating: 3/5Other topics discussedThe Last of Us Part 2 game review : Not as Good as It Thinks It Is- https://www.thewrap.com/the-last-of-us-part-2-review-not-as-good-as-it-thinks-it-is-ellie-naughty-dog/Naughty Dog's Neil Druckmann calls out journalist Jason Schreier for Anne Frank joke- https://www.ginx.tv/en/video-games/naughty-dog-s-neil-druckmann-calls-out-journalist-jason-schrier-for-anne-frank-jokeG.I. Joe - Give Him The Stick : Parody of G.I. Joe's Public Service Announcements created by Fensler films- https://www.youtube.com/watch?v=DXFdPTaCtkcVictoria's sudden spike in coronavirus cases could result in localised lockdowns- https://7news.com.au/lifestyle/health-wellbeing/victorias-sudden-spike-in-coronavirus-cases-could-result-in-localised-lockdowns-c-1113679Epstein–Barr virus (EBV) (formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.)- https://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virusOnce Upon a Time….Life (French animated series which tells the story of the human body for children.)- https://en.wikipedia.org/wiki/Once_Upon_a_Time..._LifeCells at Work! (Japanese manga series written and illustrated by Akane Shimizu. It features the anthropomorphized cells of a human body, with the two main protagonists being a red blood cell and a white blood cell she frequently encounters.)- https://en.wikipedia.org/wiki/Cells_at_Work!Cells at Work! CODE BLACK (spin-off written by Shigemitsu Harada, illustrated by Ikuta Hatsuya, and supervised by the author of the original, Akane Shimizu. Similar to the original, the series is set in a world of anthropomorphic cells working in a body. It follows a the life of a rookie Erythrocyte, AA2153, and a Neutrophil, U-1196, as they work in a poorly maintained, middle-aged body burdened by issues such as stress, smoking, drinking and the like, causing complications in the cells' work and living environment.)- https://cellsatwork.fandom.com/wiki/Cells_at_Work!_CODE_BLACKInside Ralphie (Magic School Bus episode) (Third episode of Season 1 of the animated children's series The Magic School Bus. While Ralphie hosts a TV broadcast from his sickbed, his classmates seek to discover the cause of his illness.)- https://magicschoolbus.fandom.com/wiki/Inside_RalphieFor Lunch (Magic School Bus episode) (Second episode of season one of the animated children's series The Magic School Bus. Ms. Frizzle's students explore Arnold's digestive system after he accidentally swallows his miniaturized classmates.)- https://magicschoolbus.fandom.com/wiki/For_LunchFood and Drug Administration ((FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counterpharmaceutical drugs (medications), vaccines,biopharmaceuticals,blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, animal foods & feed and veterinary products.)- https://en.wikipedia.org/wiki/Food_and_Drug_AdministrationRitalin (Methylphenidate, sold under the trade name Ritalin among others, is a stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is a first line medication for ADHD. It may be taken by mouth or applied to the skin.)- https://en.wikipedia.org/wiki/MethylphenidateTali Health (Tali Health creates game based programs to improve attention in children. TALi TRAIN is a clinically validated digital training and treatment program that addresses the world’s leading reported early childhood issue-attention difficulties, a key feature in conditions including ADHD and ASD (Autism Spectrum Disorder).)- https://talihealth.com.au/Michele Assarasakorn (comic artist | colorist on ISOLA / Gotham Academy/ Critical Role)Twitter : https://twitter.com/msassykInstagram : https://www.instagram.com/msassyk/Critical Role Wiki (A Place Documenting the Current History of Exandria)- https://criticalrole.fandom.com/wiki/Critical_Role_WikiThe World of RWBY: The Official Companion (RWBY lore book)- https://www.amazon.com/World-RWBY-Official-Companion/dp/1974704386Critical Role: Vox Machina Origins Library Edition: Series I & II Collection at Amazon-https://www.amazon.com/Critical-Role-Machina-Origins-Collection/dp/1506721737Ace Combat (Ace Combat is a hybrid arcade-style flight action video game franchise mainly developed by Bandai Namco Studios and published by Bandai Namco Entertainment.)- https://en.wikipedia.org/wiki/Ace_CombatLUFTRAUSERS (shoot 'em up video game developed by Netherlands-based indie developer studio Vlambeer and published by Devolver Digital for Microsoft Windows, OS X,Linux, PlayStation 3 and PlayStation Vita.)- https://store.steampowered.com/app/233150/LUFTRAUSERS/Guns of Icarus (Guns of Icarus Online is the original PvP steampunk airship combat game that laid the groundwork for the expanded Guns of Icarus experience, Guns of Icarus Alliance.)- https://store.steampowered.com/app/209080/Guns_of_Icarus_Online/PS5 Reveal Event & Every Next Gen Game announced- https://www.gamespot.com/articles/ps5-reveal-event-every-nextgen-game-announced-by-s/1100-6478266/Space Shuttle Challenger disaster (The Space Shuttle Challenger disaster was a fatal incident in the United States space program that occurred on Tuesday, January 28, 1986, when the Space Shuttle Challenger (OV-099) broke apart 73 seconds into its flight, killing all seven crew members aboard. The failure was caused by the failure of O-ring seals used in the joint that were not designed to handle the unusually cold conditions that existed at this launch.)- https://en.wikipedia.org/wiki/Space_Shuttle_Challenger_disasterSpace Shuttle Columbia disaster (The Space Shuttle Columbia disaster was a fatal incident in the United States space program that occurred on February 1, 2003, when the Space Shuttle Columbia (OV-102) disintegrated as it reentered the atmosphere, killing all seven crew members. During the launch of STS-107,Columbia's 28th mission, a piece of foam insulation broke off from the Space Shuttle external tank and struck the left wing of the orbiter.)- https://en.wikipedia.org/wiki/Space_Shuttle_Columbia_disasterThe Slo Mo Guys - How a TV Works in Slow Motion- https://www.youtube.com/watch?v=3BJU2drrtCMWinnie the Pooh could be banned from Shanghai Disneyland as a result of an ongoing meme used to criticize China's leader-https://www.businessinsider.com/winnie-the-pooh-shanghai-disneyland-meme-2018-11?r=AU&IR=TObama & Xi Jinping as Tigger & Winnie The Pooh- https://pbs.twimg.com/media/DsXrZ-6UwAUHGRx?format=jpg&name=900x900Shout Outs11 June 2020 – Playstation 5 reveal - https://deadline.com/2020/06/sony-playstation-5-revealed-videogames-1202957140/Sony lifted the veil to reveal the PlayStation 5, the video game console it hopes will be a significant lure for consumers this holiday season. In a live-streamed video presentation lasting more than an hour, Sony Interactive Entertainment revealed new details for the PS5, including its design and lineup of new games. Rockstar Games’ Grand Theft Auto will be included for free, and there are two dozen other games heading to the platform. The unit’s two-tone design is a shift from previous versions and gives off distinct imperial stormtrooper vibes. PS5 will be available in both a standard model with an Ultra HD Blu-ray disc drive, and a digital model without a disc drive. One of the biggest series of all time, Grand Theft Auto, will be coming to PS5, with enhanced and expanded versions of Grand Theft Auto V and Grand Theft Auto Online to launch on PS5 in the second half of 2021.15 June 2020 – Rare stone ginger beer bottle from 1930s-era sells for record price - https://www.abc.net.au/news/2020-06-15/ginger-beer-bottle-sells-for-huge-price/12353574A rare ginger beer bottle from the 1930s, made for a Warwick soft drink company, has sold for a record price in Toowoomba. It has collectors encouraging people to check their sheds and old farm dumps for possible 'buried treasure'. The hammer fell at $17,500 for the stoneware Doneley and Butler bottle. The little green lip at the top is what set it apart from bottles worth a fraction of that price."These bottles are extremely rare, there have only been two or three found in perfect condition," said auctioneer Graham Lancaster."That colour combination of glazes makes it unique worldwide."He said the Warwick bottle set a record price locally, and quite possible a world-record, for an antique crown-seal soft drink bottle of its type.16 June 2020 – Christopher Nolan’s Batman Begins turns 15 - https://comicbook.com/movies/news/batman-begins-anniversary-the-dark-knight-christopher-nolan-christian-bale/As the '90s progressed, the image of Batman on the big screen began to descend into the realm of campiness previously seen in Adam West's take on the character back in the '60s TV series and movie, which started to sour audiences on the character entirely. After a variety of reports emerged about a new take on the character in the early '00s, fans were given Christopher Nolan's gritty and grounded origin story for the character in 2005, debuting Christian Bale as the Dark Knight. This new take on the character harkened back to some of the more grounded interpretations of the character, while adding just enough whimsy to remind audiences that this was still a comic book movie. Batman Begins went on to take in $371 million worldwide, a fraction of the figures that subsequent superhero movies would go on to earn, That film's success might not have been groundbreaking, but it set the stage for The Dark Knight and The Dark Knight Rises, with some audiences considering those films to be the best comic book films of all time, both of which earned major box office hauls and the former earning Heath Ledger a posthumous Oscar for his performance as the Joker.18 June 2020 – Dame Vera Lynn passes away at 103 - https://www.bbc.com/news/uk-53091856The singer was best known for performing hits such as We'll Meet Again to troops on the front line in countries including India and Egypt. Six weeks ago, ahead of the 75th anniversary of VE Day and during the height of the coronavirus pandemic, Dame Vera said simple acts of bravery and sacrifice still define our nation. A week later, she became the oldest artist to get a top 40 album in the UK, beating her own record when her greatest hits album re-entered the charts at number 30. Born in London's East Ham in 1917, Dame Vera's singing talent was discovered at a young age and by age 11 she had left school to pursue a full-time career as a dancer and singer. Lynn devoted much time and energy to charity work connected with ex-servicemen, disabled children and breast cancer. She was held in great affection by Second World War veterans and in 2000 was named the Briton who best exemplified the spirit of the 20th century. Paying tribute, Prime Minister Boris Johnson said the singer's "charm and magical voice entranced and uplifted our country in some of our darkest hours". "Her voice will live on to lift the hearts of generations to come," he said. She died at the age of 103 in Ditchling,East Sussex.19 June 2020 – Sir Ian Holm passes away at 88 - https://www.theguardian.com/film/2020/jun/19/ian-holm-dies-alien-chariots-of-fire-bilbo-bagginsSir Ian Holm, an acclaimed British actor whose long career included roles in Chariots of Fire and The Lord of the Rings has died. A star of stage and screen, Sir Ian won a Tony Award for best featured actor as Lenny in Harold Pinter's play The Homecoming in 1967. He won a British Academy Film Award and gained a supporting-actor Oscar nomination for portraying pioneering athletics coach Sam Mussabini in the hit 1982 film Chariots of Fire. His other well-known film roles include Ash in Alien, Father Vito Cornelius in The Fifth Element, Chef Skinner in Ratatouille, and Bilbo Baggins in The Lord of the Rings and The Hobbit film series. Sir Ian was knighted in 1998 for his services to drama. He died from Parkinson’s disease in London.Remembrances16 June 1804 – Johann Adam Hiller - https://en.wikipedia.org/wiki/Johann_Adam_HillerGerman composer,conductor and writer on music, regarded as the creator of the Singspiel, an early form of German opera. It is a form of German-language music drama, now regarded as a genre of opera. It is characterized by spoken dialogue, which is alternated with ensembles,songs, ballads, and arias which were often strophic, or folk-like. Singspiel plots are generally comic or romantic in nature, and frequently include elements of magic, fantastical creatures, and comically exaggerated characterizations of good and evil. In many of these operas he collaborated with the poet Christian Felix Weiße. Furthermore, Hiller was a teacher who encouraged musical education for women, his pupils including Elisabeth Mara and Corona Schröter. He was Kapellmeister of Abel Seyler's theatrical company, and became the first Kapellmeister of Leipzig Gewandhaus. To Hiller has been given the credit of being the originator of the Singspiel, the beginning of German comedy opera as distinct from the French and Italian developments. The most important of his operas were: Lottchen am Hofe (Lottie at court, 1760),Der Teufel ist los (The devil is loose, 1768), and Poltis, oder Das gerettete Troja (Poltis, or Troy rescued, 1782). The lyrics of all his Singspiele were of considerable musical value, and were long popular. Among his sacred compositions are: A Passion Cantata, Funeral Music in Honor of Hasse, a setting of the one hundredth Psalm; and a few symphonies. He died at the age of 76 in Leipzig.16 June 1858 – John Snow - https://en.wikipedia.org/wiki/John_SnowEnglish physician and a leader in the development of anaesthesia and medical hygiene. He is considered one of the founders of modern epidemiology, in part because of his work in tracing the source of a cholera outbreak in Soho, London, in 1854, which he curtailed by removing the handle of a water pump. Snow's findings inspired the adoption of anaesthesia as well as fundamental changes in the water and waste systems of London, which led to similar changes in other cities, and a significant improvement in general public health around the world. John Snow was one of the first physicians to study and calculate dosages for the use of ether and chloroform as surgical anaesthetics, allowing patients to undergo surgical and obstetric procedures without the distress and pain they would otherwise experience. He designed the apparatus to safely administer ether to the patients and also designed a mask to administer chloroform. He personally administered chloroform to Queen Victoria when she gave birth to the last two of her nine children, Leopold in 1853 and Beatrice in 1857 and was still not yet knighted, leading to wider public acceptance of obstetric anaesthesia. John Snow studied chloroform as much as he studied ether, which was introduced in 1847 by James Young Simpson, a Scottish obstetrician. He realised that chloroform was much more potent and required more attention and precision when administering it. Snow first realised this with Hannah Greener, a 15-year-old patient who died on 28 January 1848 after a surgical procedure that required the cutting of her toenail. She was administered chloroform by covering her face with a cloth dipped in the substance. However, she quickly lost pulse and died. After investigating her death and a couple of deaths that followed, he realized that chloroform had to be administered carefully and published his findings in a letter to The Lancet. Snow was a skeptic of the then-dominant miasma theory that stated that diseases such as cholera and bubonic plague were caused by pollution or a noxious form of "bad air". The germ theory of disease had not yet been developed, so Snow did not understand the mechanism by which the disease was transmitted. His observation of the evidence led him to discount the theory of foul air. He first published his theory in an 1849 essay, On the Mode of Communication of Cholera, followed by a more detailed treatise in 1855 incorporating the results of his investigation of the role of the water supply in the Soho epidemic of 1854. By talking to local residents (with the help of Reverend Henry Whitehead), he identified the source of the outbreak as the public water pump on Broad Street (now Broadwick Street). Although Snow's chemical and microscope examination of a water sample from the Broad Street pump did not conclusively prove its danger, his studies of the pattern of the disease were convincing enough to persuade the local council to disable the well pump by removing its handle (force rod). Snow later used a dot map to illustrate the cluster of cholera cases around the pump. He also used statistics to illustrate the connection between the quality of the water source and cholera cases. He showed that homes supplied by the Southwark and Vauxhall Waterworks Company, which was taking water from sewage-polluted sections of the Thames, had a cholera rate fourteen times that of those supplied by Lambeth Waterworks Company, which obtained water from the upriver, cleaner Seething Wells. Snow's study was a major event in the history of public health and geography. It is regarded as the founding event of the science of epidemiology. He died from stroke at the age of 45 in London.16 June 1869 – Charles Sturt - https://en.wikipedia.org/wiki/Charles_SturtCharles Napier Sturt, British officer and explorer of Australia, and part of the European exploration of Australia. He led several expeditions into the interior of the continent, starting from Sydney and later from Adelaide. His expeditions traced several of the westward-flowing rivers, establishing that they all merged into the Murray River, which flows into the Southern Ocean. He was searching to prove his own passionately held belief that an "inland sea" was located at the centre of the continent. Sturt found the conditions and climate in New South Wales much better than he expected, and he developed a great interest in the country. Sturt received approval from Governor Darling on 4 November 1828 to explore the area of the Macquarie River in western New South Wales. The party faced the ordeal of rowing back upriver on the Murray and Murrumbidgee, against the current, in the heat of an Australian summer. Their supplies ran out and, when they reached the site of Narrandera in April, they were unable to go any further. Sturt sent two men overland in search of supplies and they returned in time to save the party from starvation. But Sturt went blind for some months and never fully recovered his health. By the time they reached Sydney again, they had rowed and sailed nearly 2,900 kilometres of the river system. Sturt believed that it was his destiny to discover a great salt water lake, known as 'the inland sea', in the middle of Australia. At very least, he wanted to be the first explorer to plant his foot in 'the centre' of Australia. In August 1844, he set out with a party of 15 men, 200 sheep, six drays, and a boat to explore north-western New South Wales and to advance into central Australia. They travelled along the Murray and Darling rivers before passing the future site of Broken Hill. They were stranded for months by the extreme summer conditions near the present site of Milparinka. When the rains eventually came, Sturt moved north and established a depot at Fort Grey (today this site is within Sturt National Park). With a small group of men, including explorer John McDouall Stuart as his draughtsman, Sturt pressed on across what is now known as Sturt's Stony Desert and into the Simpson Desert. Unable to go further, he turned back to the depot. Sturt made a second attempt to reach the centre of Australia, but he developed scurvy in the extreme conditions. His health broke down and he was forced to abandon the attempt. John Harris Browne, surgeon on the expedition, assisted Sturt, took over leadership of the party and, after travelling a total of 3,000 miles (4,800 km), brought it back to safety. He died from heart failure at the age of 74 in Cheltenham, Gloucestershire.16 June 1977 – Wernher von Braun - https://en.wikipedia.org/wiki/Wernher_von_BraunGerman and later American aerospace engineer and space architect. He was the leading figure in the development of rocket technology in Nazi Germany and a pioneer of rocket and space technology in the United States. While in his twenties and early thirties, von Braun worked in Nazi Germany's rocket development program. He helped design and develop the V-2 rocket at Peenemünde during World War II. Though a member of the SS, following the war he was secretly moved to the United States, along with about 1,600 other German scientists, engineers, and technicians, as part of Operation Paperclip. He worked for the United States Army on an intermediate-range ballistic missile program, and he developed the rockets that launched the United States' first space satellite Explorer 1. In 1960, his group was assimilated into NASA, where he served as director of the newly formed Marshall Space Flight Center and as the chief architect of the Saturn V super heavy-lift launch vehicle that propelled the Apollo spacecraft to the Moon. In 1967, von Braun was inducted into the National Academy of Engineering, and in 1975, he received the National Medal of Science. He advocated a human mission to Mars. Von Braun also developed the idea of a Space Camp that would train children in fields of science and space technologies, as well as help their mental development much the same way sports camps aim at improving physical development. Von Braun took a very conservative approach to engineering, designing with ample safety factors and redundant structure. This became a point of contention with other engineers, who struggled to keep vehicle weight down so that payload could be maximized. As noted above, his excessive caution likely led to the U.S. losing the race to put a man into space with the Soviets. He died from pancreatic cancer at the age of 65 in Alexandria, Virginia.Famous Birthdays16 June 1801 – Julius Plücker - https://en.wikipedia.org/wiki/Julius_Pl%C3%BCckerGerman mathematician and physicist. He made fundamental contributions to the field of analytical geometry and was a pioneer in the investigations of cathode rays that led eventually to the discovery of the electron. He also vastly extended the study of Lamé curves. In 1836, Plücker was made professor of physics at University of Bonn. In 1858, after a year of working with vacuum tubes of his Bonn colleague Heinrich Geißler, he published his first classical researches on the action of the magnet on the electric discharge in rarefied gases. He found that the discharge caused a fluorescent glow to form on the glass walls of the vacuum tube, and that the glow could be made to shift by applying an electromagnet to the tube, thus creating a magnetic field. It was later shown that the glow was produced by cathode rays. Plücker, first by himself and afterwards in conjunction with Johann Hittorf, made many important discoveries in the spectroscopy of gases. He was the first to use the vacuum tube with the capillary part now called a Geissler tube, by means of which the luminous intensity of feeble electric discharges was raised sufficiently to allow of spectroscopic investigation. He anticipated Robert Wilhelm Bunsen and Gustav Kirchhoff in announcing that the lines of the spectrum were characteristic of the chemical substance which emitted them, and in indicating the value of this discovery in chemical analysis. According to Hittorf, he was the first who saw the three lines of the hydrogen spectrum, which a few months after his death, were recognized in the spectrum of the solar protuberances. In 1865, Plücker returned to the field of geometry and invented what was known as line geometry in the nineteenth century. In projective geometry, Plücker coordinates refer to a set of homogeneous co-ordinates introduced initially to embed the set of lines in three dimensions as a quadric in five dimensions. The construction uses 2×2 minor determinants, or equivalently the second exterior power of the underlying vector space of dimension 4. It is now part of the theory of Grassmannians, to which these co-ordinates apply in generality (k-dimensional subspaces of n-dimensional space). He was born in Elberfeld,Duchy of Berg,Holy Roman Empire.16 June 1915 – John Tukey - https://en.wikipedia.org/wiki/John_TukeyJohn Wilder Tukey, American mathematician best known for development of the Fast Fourier Transform (FFT) algorithm and box plot. The Tukey range test, the Tukey lambda distribution, the Tukey test of additivity, and the Teichmüller–Tukey lemma all bear his name. He is also credited with coining the term 'bit'. Early in his career Tukey worked on developing statistical methods for computers at Bell Labs where he invented the term "bit" in 1947. n 1970, he contributed significantly to what is today known as the jackknife estimation—also termed Quenouille–Tukey jackknife. He introduced the box plot in his 1977 book, "Exploratory Data Analysis". He is also the creator of several little-known methods such as the trimean and median-median line, an easier alternative to linear regression. He also contributed to statistical practice and articulated the important distinction between exploratory data analysis and confirmatory data analysis, believing that much statistical methodology placed too great an emphasis on the latter. Though he believed in the utility of separating the two types of analysis, he pointed out that sometimes, especially in natural science, this was problematic and termed such situations uncomfortable science. Tukey coined many statistical terms that have become part of common usage, but the two most famous coinages attributed to him were related to computer science. While working with John von Neumann on early computer designs, Tukey introduced the word "bit" as a contraction of "binary digit" The term "bit" was first used in an article by Claude Shannon in 1948. In 2000, Fred Shapiro, a librarian at the Yale Law School, published a letter revealing that Tukey's 1958 paper "The Teaching of Concrete Mathematics" contained the earliest known usage of the term "software" found in a search of JSTOR's electronic archives, predating the OED's citation by two years. This led many to credit Tukey with coining the term, particularly in obituaries published that same year, although Tukey never claimed credit for any such coinage. In 1995, Paul Niquette claimed he had originally coined the term in October 1953, although he could not find any documents supporting his claim.The earliest known publication of the term "software" in an engineering context was in August 1953 by Richard R. Carhart, in a RAND Corporation research memorandum. He was born in New Bedford, Massachusetts.16 June 1909 – Archie Carr - https://en.wikipedia.org/wiki/Archie_CarrArchie Fairly Carr, Jr., American herpetologist,ecologist and a pioneering conservationist. He was a Professor of Zoology at the University of Florida. In 1987 he was awarded the Eminent Ecologist Award by the Ecological Society of America. He made extraordinary contribution to sea turtle conservation by way of bringing attention to the world's declining turtle populations due to over-exploitation and loss of safe habitat. He started out as a high school science teacher before becoming a college professor. He published numerous books and articles, including Ulendo: Travels of a Naturalist in and out of Africa, High Jungles and Low, So Excellent a Fishe (about his green turtles), The Windward Road and several Time-Life books such as The Everglades and The Reptiles. He was also the author of the Handbook of Turtles, and with Coleman J. Goin, Guide to the Reptiles, Amphibians and Freshwater Fishes of Florida. While a serious scientific and nature writer, he also had a remarkable sense of humor, which led him to publish the parody of scientific taxonomic keys - his A Subjective Key to the Fishes of Alachua County, Florida, affectionately known as the "Carr Key". Carr was also known for his efforts in conservation, especially for sea turtles, helping convince Costa Rica to establish Tortuguero National Park in 1975. He was a co-founder of the Caribbean Conservation Corporation, which helps to save and monitor sea turtles in Tortuguero,Costa Rica. He was often joined in his conservation work by his wife Marjorie Carr, who was a major advocate for conservation in her own right. In 1952 Carr was awarded the Daniel Giraud Elliot Medal from the National Academy of Sciences. He was born in Mobile, Alabama.Events of Interest16 June 1884 – The first purpose-built roller coaster, LaMarcus Adna Thompson's "Switchback Railway", opens in New York's Coney Island amusement park. - https://www.history.com/this-day-in-history/first-roller-coaster-in-america-opensKnown as a switchback railway, it was the brainchild of LaMarcus Thompson, traveled approximately six miles per hour and cost a nickel to ride. The new entertainment was an instant success and by the turn of the century there were hundreds of roller coasters around the country. For five cents, riders would climb a tower to board the large bench-like car and were pushed off to coast 600 ft (183 m) down the track to another tower. The car went just over 6 mph (9.7 km/h). At the top of the other tower the vehicle was switched to a return track or "switched back" (hence the name). The new entertainment was an instant success and by the turn of the century there were hundreds of roller coasters around the country.16 June 1911 – IBM founded as the Computing-Tabulating-Recording Company in Endicott, New York. - http://www.techgetz.com/history-of-ibm/In 1911 the company that leased Unit record equipment, especially Hollerith punched cards and card readers to government bureaus and insurance agencies, became the Computing-Tabulating-Recording Company (CTR). Thomas J. Watson (1874-1956) took over in 1924, using the name “International Business Machines.” IBM expanded into electric typewriters and other office machines. Watson was a salesman and concentrated on building a highly motivated, very well paid sales force that could craft solutions for clients unfamiliar with the latest technology. His motto was “THINK”; customers were advised to not “fold, spindle or mutilate” the delicate cardboard cards.16 June 2012 – The United States Air Force's robotic Boeing X-37B spaceplane returns to Earth after a classified 469-day orbital mission. - https://www.space.com/16110-secret-x37b-space-plane-landing.htmlThe unmanned X-37B spacecraft, also known as Orbital Test Vehicle-2 (OTV-2), glided back to Earth on autopilot, touching down at California's Vandenberg Air Force Base at 5:48 a.m. PDT (8:48 a.m. EDT, 1248 GMT). The landing brought to an end the X-37B program's second-ever spaceflight, a mission that lasted more than 15 months with objectives that remain shrouded in secrecy. The X-37B stayed in orbit for 469 days this time, more than doubling the 225 days its sister ship, OTV-1, spent in space last year on the program's maiden flight. Officials at Vandenberg said the spacecraft conducted "on-orbit experiments" during its mission. Exactly what the spacecraft, which is built by Boeing, was doing up there for so long is a secret. The details of the X-37B's mission, which is overseen by the Air Force's Rapid Capabilities Office, are classified, as is its payload. This secrecy has led to some speculation, especially online and abroad, that the X-37B could be a space weapon of some sort — perhaps a sophisticated satellite-killer. Some experts also suspect that the vehicle may be an orbital spy platform. "This is a test vehicle to prove the materials and capabilities, to put experiments in space and bring them back and check out the technologies," Richard McKinney, the Air Force's deputy undersecretary for space programs.16 June 2016 – Shanghai Disneyland Park, the first Disney Park in Mainland China, opens to the public - https://www.dw.com/en/distinctly-chinese-disneyland-opens-in-shanghai/a-19332984Shanghai Disney Resort, the first Disney resort in Mainland China and the sixth worldwide, celebrated its historic Grand Opening today, culminating one of Disney's most ambitious projects ever. The wonder and imagination of Disney greeted the people of China in magical new ways as the gates opened to Shanghai Disneyland, a theme park like no other with the biggest, tallest castle in any Disney park, the first pirate-themed land and Disney's most technologically advanced park to date. Walt Disney Co. CEO Bob Iger and Chinese Vice Premier Wang Yang cut a red ribbon together, signaling the Communist Party's endorsement of the $5.5 billion (4.87 billion euro) resort - one of the largest foreign investments in China. The lavish ceremony featured a children's choir singing "When You Wish Upon a Star," as well as actors dressed as Sleeping Beauty, Donald Duck, and other Disney characters dancing on stage. The entrance of the park is called "Mickey Avenue" instead of "Main Street USA." Stores feature Minnie Mouse in traditional quipau dresses and the Wandering Moon Teahouse is modeled after a building in eastern China. Shanghai Disney Resort is filled with immersive Disney storytelling, thrilling attractions, spectacular live entertainment and memory-making experiences designed to inspire and delight Chinese guests. The world-class vacation destination includes a magical theme park with six themed lands, two imaginatively designed hotels, a Disneytown shopping and dining district, and Wishing Star Park recreational area.IntroArtist – Goblins from MarsSong Title – Super Mario - Overworld Theme (GFM Trap Remix)Song Link -https://www.youtube.com/watch?v=-GNMe6kF0j0&index=4&list=PLHmTsVREU3Ar1AJWkimkl6Pux3R5PB-QJFollow us onFacebook- Page - https://www.facebook.com/NerdsAmalgamated/- Group - https://www.facebook.com/groups/440485136816406/Twitter - https://twitter.com/NAmalgamatedSpotify - https://open.spotify.com/show/6Nux69rftdBeeEXwD8GXrSiTunes -https://itunes.apple.com/au/podcast/top-shelf-nerds/id1347661094RSS -http://www.thatsnotcanonproductions.com/topshelfnerdspodcast?format=rssInstagram - https://www.instagram.com/nerds_amalgamated/Email - Nerds.Amalgamated@gmail.comSupport via Podhero- https://podhero.com/podcast/449127/nerds-amalgamatedRate & Review us on Podchaser - https://www.podchaser.com/podcasts/nerds-amalgamated-623195

Časovnica: [00:00:30] Aktualne teme: o nadaljevanju podcasta, projektu skupine evidance-based pristopa k prehrani in vadbi ter poskusu svetovnega rekorda v log liftu. [00:08:30] Kako je pot do naših ciljev lahko izvor sreče in zadovoljstva. Zakaj se moramo konstantno premikati proti nekemu cilju. O zanemarjanju prihodnosti in upiranju kratkoročnim ciljem ter zakaj je to pomembno pri delu na področju fitnesa in zdravja. [00:37:15] Ali je kava dober vir kofeina za športnike? O nevarnosti predoziranja s kofeinom z določenimi komercialno dostopnimi izdelki. [00:49:00] Omega-3 indeks. Kaj je in zakaj je pomemben? [01:22:15] Omega-3 indeks in športniki. Kako dosledni so športniki pri zagotavljanju potreb po omega-3? Zakaj športniki potrebujejo več omega-3 [01:37:15] Zaključek.   Omenjeni članki: Hipoteza rdeče kraljice: Brockhurst et al. (2014) ‘Running with the Red Queen: the role of biotic conflicts in evolution', Proceedings of the Royal Society B: Biological Sciences, 281(1797), p. 20141382. https://doi.org/10.1098/rspb.2014.1382 "Zanemarjanje prihodnosti": Frederick et al. (2002) ‘Time Discounting and Time Preference: A Critical Review', Journal of Economic Literature, 40(2), pp. 351–401.  https://doi.org/10.1257/002205102320161311 Vsebnost kofeina v kavi: McCusker et al. (2003). Caffeine Content of Specialty Coffees. Journal of Analytical Toxicology, 27(7), 520–522.  https://doi.org/10.1093/jat/27.7.520  Omega-3 index in zdravje: von Schacky, C. (2020) ‘Omega-3 index in 2018/19', Proceedings of the Nutrition Society, (October 2019), pp. 1–7. https://doi.org/10.1017/S0029665120006989Sarteret al. (2015) ‘Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement', Clinical Nutrition. Elsevier Ltd, 34(2), pp. 212–218. https://doi.org/10.1016/j.clnu.2014.03.003 Harris et al. (2018) ‘Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study', Journal of Clinical Lipidology. Elsevier Inc, 12(3), pp. 718-727.e6. https://doi.org/10.1016/j.jacl.2018.02.010 Harris et al. (2016) ‘Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico–Heart Failure trial', Nutrition Research. Elsevier B.V., 36(9), pp. 989–994. https://doi.org/10.1016/j.nutres.2016.06.012 Harris et al. (2017) ‘The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies', Atherosclerosis. Elsevier Ltd, 262, pp. 51–54. https://doi.org/10.1016/j.atherosclerosis.2017.05.007 ALA nimajo enakih koristi kot EPA in DHA: Burdge et al. (2002) ‘Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women', British Journal of Nutrition, 88(04), p. 411. https://doi.org/10.1079/BJN2002689 Wendland. (2006) ‘Effect of linolenic acid on cardiovascular risk markers: a systematic review', Heart, 92(2), pp. 166–169. https://doi.org/10.1136/hrt.2004.053538 Su et al. (2018) ‘Effect of dietary alpha-linolenic acid on blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials', European Journal of Nutrition. Springer Berlin Heidelberg, 57(3), pp. 877–891. https://doi.org/10.1007/s00394-017-1386-2 Jovanovski et al. (2017) ‘The effect of alpha-linolenic acid on glycemic control in individuals with type 2 diabetes', Medicine (United States), 96(21). https://doi.org/10.1097/MD.0000000000006531 Omega-3 index pri športnikih: Ritz et al. (2020). Dietary and Biological Assessment of the Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis. PloS one, 15(4), e0228834. https://doi.org/10.1371/journal.pone.0228834 Davinelli et al. (2019). Relationship Between Distance Run Per Week, Omega-3 Index, and Arachidonic Acid (AA)/Eicosapentaenoic Acid (EPA) Ratio: An Observational Retrospective Study in Non-elite Runners. Frontiers in physiology, 10, 487. https://doi.org/10.3389/fphys.2019.00487   Sledite nam: Nenadov instagram: @nenad.feelgood Matjažev instagram: @matjaz.feelgood Feelgood Skupnost na Facebooku: https://bit.ly/feelgoodskupnost Spletna stran: https://www.feel-good.si   Poslušate nas lahko na: Podbean: https://bit.ly/podbean-zdp Stitcher: https://bit.ly/stitcher-zdp Pocket Casts: https://bit.ly/pocket-zdp Podcast Addict: https://bit.ly/addict-zdp Castbox: https://bit.ly/castbox-zdp iTunes: https://bit.ly/itunes-zdp  

Thalassemia is a dangerous condition that has the ability to cut off some oxygen from reaching the body. Learn how it does this and more in this week's episode!https://www.brainontheloose.comhttps://www.horizons-app.comLeave an Review on Apple Podcasts: https://podcasts.apple.com/us/podcast/scrubcaps-a-health-and-medical-podcast/id1442030058References:https://rarediseases.info.nih.gov/diseases/7756/thalassemia https://www.mayoclinic.org/diseases-conditions/thalassemia/symptoms-causes/syc-20354995 https://www.nhlbi.nih.gov/health-topics/thalassemias Support the show (http://patreon.com/ Nathanhidajatscrubcaps)

The TWiP'ers solve the case of the Sudanese Boy With Fever, and reveal antibodies against that slow invasion of red blood cells potentiate other malaria-blocking antibodies. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Antibodies that slow malaria invasion (Cell) Hero: Sir Leonard Rogers (pdf) Letters read on TWiP 175 Become a patron of TWiP. Case Study for TWiP 175 70 yo man born in India, came to US 1985. Has not gone back for 2-3 years. Admitted with acute onset of fever, cough, not eating well. Was fine until a week ago, had lost consciousness, fever 102F. Negative cultures for urine and blood. Some kidney stones, type II diabetes, elevated cholesterol, no surgeries. No family medical issues. Started on vancomycin on zosyn. Works in post office, lives with house in private home. No toxic habits. Has history of hiking trip 1-2 months prior, in Rhode Island, in June. No pets, animals. Exam unimpressive. Labs: crit 25, hemoglobin 9. Platelets 39. Bilirubin 5.3. Liver enzymes slightly elevated. Chest CT clear, blood smear: anisocytosis, microcytosis, polychromasia, 4.3% reticulocytes. Daniel orders one test, 90 minutes later starts treatment. HIV negative.   Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

  You can contact Blood & Cancer at podcasts@mdedge.com and you can follow MDedge Hematology Oncology on Twitter @MDedgeHemOnc. Episode 11: Blood & Cancer host David Henry, MD, welcomes John Glaspy, MD, to talk about anemia in cancer. And in today's Clinical Correlation, Ilana Yurkiewicz, MD, talks apathy. Dr. Yurkiewicz has a column at MDedge, which you can find by clicking here. Show notes   By Emily Bryer, DO, resident in the department of internal medicine, University of Pennsylvania Hemoglobin is associated with quality of life and functional status, and quality of life improves continuously as hemoglobin rises from low (8 g/dL) to normal (12 g/dL) levels. The complete workup of anemia involves reticulocyte count, iron studies, folate, B12, peripheral smear, and creatinine. Anemia is a consequence of 1) cancer and 2) chemotherapy In patients with malignancy, the inflammatory state results in iron-restricted erythropoiesis, so patients may be functionally iron deficient even if their iron stores are replete. How do we treat anemia in cancer? Blood transfusion to rapidly improve hemoglobin Intravenous iron, if iron deficient Erythrocyte stimulating agents (ESA), if iron stores are replete. (Although IV iron augments ESA response in all cancer studies reported so far.) Risks associated with blood transfusion: Infection, transfusion-related-lung-injury, reactions to mismatched or well-matched blood, and iron overload (specifically in myelodysplastic syndrome). Recent FDA-mandated studies in anemic metastatic breast and non-small-cell lung cancer patients have demonstrated that there is no difference in survival among patients who receive ESA or placebo to treat their cancer/chemotherapy-associated anemia. HIF-1-alpha (hypoxia-inducible-factor) is a transcription factor produced in response to hypoxia. New class of drugs stabilizing HIF can result in both an increase in erythropoiesis and a decrease in hepcidin. References   2010 Dec 2;116(23):4754-61. Cancer Metastasis Rev.2007 Jun;26(2):341-52. Support Care Cancer.2006 Dec;14(12):1184-94. Cochrane Database Syst Rev.2016 Feb 4;2:CD009624. International Journal of Clinical Transfusion Medicine. 2018;6:21-31.    

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPanorama solve the case of the Dutch Woman with Wormy Objects in Her Stool, dissect a study on cytoadhesion of malaria infected red blood cells, and introduce Parasitology Superheroes. Become a patron of TWiP. Links for this episode: Myiasis (Wikipedia) Cytoadhesion of Plasmodium in severe malaria (PLoS Path) Image credit Letters read on TWiP 123 This episode is sponsored by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Case Study for TWiP 123 Nurse in early 20s, recent grad, decides to spend year in global health internship in western DR/Haitian border. On her foot has skin issue: told is fungal infection, using antifungal cream, is getting worse. Several days, only on one foot. Healthy, no past med/surg/allergies, no meds, no HIV, lives with local family. Daughter, wife, husband, cat. No toxic habits. Originally from US, swims, walks barefoot to and from, shoes off in house. Easts local food, exposure to dogs, cats, sister. Very itchy, but not open; rash area is raised. Blistery in certain areas, involves different areas in different days, snakelike.  Send your case diagnosis, questions and comments to twip@microbe.tv

The post Erythrocyte Sedimentation Rate (ESR) appeared first on NURSING.com.

Neurotrauma – How to Put Humpty together again Humpty is a 23 year old egg, who fancied himself as a bit of a Hipster. Little did poor old Humpty know that his day was about to end in tears and he was to join the 1000 other Australians who annually have a severe head injury.  The talk focuses on Traumatic Brain Injury. There is particular emphasis on Traumatic Subarachnoid Haemorrhage and Transfusion Thresholds in Traumatic Brain Injury. The discussion explores the incidence and patterns of vasospasm following tSAH and the role, if any, of nimodipine and other therapies usually reserved for the aneurysm SAH population  The optimal target haemoglobin concentration following TBI is unknown. The discussion looks at the literature and explores the pathophysiology of anaemia in this setting.  A blood conservation strategy for patients with TBI is outlined  

Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum, and introduce a new case study. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Malaria life cycle (jpg) cAMP regulates gametocyte infected erythrocyte deformability (PLoS Path) P. falciparum in bone marrow (Blood) Image credit Letters read on TWiP 91 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Links for this episode: Dermatobia hominis (Wikipedia) Plasmodium falciparum erythrocyte invasion (Science) Plasmodium life cycle (TWiP #10) Letters read on TWiP 90 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Interview with Claude Bagnis, Research Director of EFS, Marseille, France. Dr. Bagnis discusses the topic 'In vitro genetic manipulation of erythrocyte antigens'.The interview is led by Shaun McCann, Chair of EHATol Unit, Member of EHA Education Committee.

Interview with Claude Bagnis, Research Director of EFS, Marseille, France. Dr. Bagnis discusses the topic 'In vitro genetic manipulation of erythrocyte antigens'.The interview is led by Shaun McCann, Chair of EHATol Unit, Member of EHA Education Committee.

Tue, 1 Jan 2008 12:00:00 +0100 https://epub.ub.uni-muenchen.de/17756/1/cclm.2008.268.pdf Stauch, Thomas; Mueller, Wilhelm; Vogeser, Michael

Background: The erythrocyte binding antigen 175 (EBA-175) is a 175 kDa antigen of Plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. The antigen is also supposed to be partly responsible for the invasion of erythrocytes by merozoites. EBA-175 has been sequenced from the FCR-3 and CAMP strains of P. falciparum. The sequences were identical in most parts of the gene. Differences were apparent in a 423 bp segment in the FCR-3 strain, the F-Fragment, that is not found in the CAMP-strain and a 342 bp segment, the C-Fragment, which is present in the CAMP-strain but not in the FCR-3-strain. The aim of this study was to assess the distribution of the two EBA-175-alleles in the Lao PDR. Materials & Methods: Altogether, 240 blood-samples were collected in two areas of the country: Attapeu in the south and Lung Namtha in the north. Subsequently, the material was scanned for the F- and C-fragments. Results: In the whole study population, 52% carried the F- fragment, and 41% the C-fragment while seven percent of the patients were infected with at least two parasite strains and showed both alleles. Conclusion: Distribution of the alleles showed significant differences between the north and the south province. Reasons for this include possible importation of different parasite strains from neighbouring countries.

Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage. Although in organs other than the lung leukocytes interact with the vascular endothelium only in postcapillary venules, alveolar capillaries are considered to be the site of leukocyte sequestration in the lung. However, pulmonary venules and arterioles have not been investigated systematically after complement activation so far, A closed thoracic window was implanted in anesthetized rabbits; leukocytes and red blood cells were stained, and the movement of these cells was measured in superficial pulmonary arterioles, venules and alveolar capillaries using fluorescence video microscopy before and 30 and 60 min after infusion of cobra venom factor (CVF). Erythrocyte velocity and macrohemodynamic conditions did not change after CVF infusion and were not different from the sham-treated controls. The number of sticking leukocytes increased significantly compared to baseline and control: by 150% in arterioles and in venules and by 740% in alveolar capillaries within 60 min after CVF infusion. The width of alveolar septa in vivo was significantly enlarged after CVF infusion, indicating interstitial pulmonary edema. At the end of the experiments, myeloperoxidase activity was higher in the CVF group, showing leukocyte sequestration in the whole organ. It is concluded that complement activation by CVF induces leukocyte sequestration in lung arterioles, venules and alveolar capillaries and leads to mild lung injury.

Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/8183/1/improvement_of_the_predictive_value_of_cd4plus_lymphocyte_count_8183.pdf Bogner, Johannes R.; Koch, Meinrad A.; Burkowitz, Jörg; Koch, Judith; Skarabis, Horst; Bek, Barbara; Schwartländer, Bernhard

Mon, 1 Jan 1990 12:00:00 +0100 https://epub.ub.uni-muenchen.de/8083/1/8083.pdf Goebel, Frank-Detlef; Bäcker, U.; Matuschke, A.; Heinrich, B.; Gathof, B.; Bogner, Johannes R.