Podcasts about lipoproteins

ไลฟ์ #90: หลักฐานทางคลินิคและพยาธิวิทยา ที่สนับสนุน “The zero-LDL Hypothesis”วันจันทร์ 24 ก.พ. 2568เวลา 20.00 น.✅ จากหลักฐาน A consensus statement from the European Atherosclerosis Society Consensus Panel“Low-density Lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic. Epidemiologic, and clinical studies.ตีพิมพ์ใน European Heart Journal 24 April, 2017 ซึ่งรวบรวมการติดตามคนไข้ไป 20 million person years พบความสัมพันธ์เชิงเส้นตรงระหว่างระดับ LDL-Cholesterol กับ ความเสี่ยงของโรคหลอดเลือดหัวใจ ยิ่งลดระดับ LDL-Cholesterol ได้ต่ำเท่าไหร่ ความเสี่ยงของโรคหลอดเลือดหัวใจก็ลดลงเท่านั้น✅ ถึงแม้ว่าจะมีหลักฐานทางคลินิกที่สนับสนุนผลลัพธ์ของการลดระดับ LDL-C ในการป้องกันการเกิดโรคหลอดเลือดหัวใจมากแค่ไหนก็ตาม มันก็ยังคงน่าสนใจเป็นอย่างยิ่งที่จะศึกษาว่า การลดระดับ LDL-C ให้ต่ำอย่างยิ่งยวด มีผลกระทบต่อภาวะธำรงดุลของไขมันในเลือด (Lipid Homeostasis) หรือไม่

Dr. Ron Krauss is a prominent American scientist and researcher known for his work in lipid metabolism and cardiovascular disease. He is a senior scientist at the Children's Hospital Oakland Research Institute and has made significant contributions to our understanding of how different types of cholesterol and lipoproteins affect heart disease risk. His research has been influential in shaping current guidelines on cholesterol management and has advanced our knowledge of the complex interactions between diet, genetics, and cardiovascular health.EPISODE OUTLINE:00:00 Introduction and the Genetic Factor in Heart Disease03:22 Profiling Lipids and Lipoproteins for Heart Disease Risk08:04 The Impact of Carbohydrates on Metabolic Syndrome13:19 Challenges of Weight Loss and the Potential Benefits of Medication22:16 Personalized Medicine and Individual Genetic Profiles in Dietary Recommendations32:36 The Gut Microbiome and Genetics36:14 Obesity and Heart Disease40:10 Preventing Fat Accumulation in Childhood44:24 The Benefits of Endurance Exercise51:51 Stress, Sleep, and Heart Disease RiskTRANSCRIPT:https://share.transistor.fm/s/079e62ca/transcript.txtEPISODE LINKS:https://profiles.ucsf.edu/ronald.kraussPODCAST INFO:YouTube:   / @tysonpopplestone9467 Apple Podcasts: https://podcasts.apple.com/au/podcast...Spotify: https://open.spotify.com/show/2gWvUUY...RSS: https://feeds.transistor.fm/popcultureSOCIALS:- Instagram:   / tysonpopplestone - YouTube:    / @tysonpopplestone9467  

In this episode of *ReInvent Healthcare*Dr. Ritamarie Loscalzo uncovers the critical gaps between conventional and functional lab testing. If you're relying solely on standard test panels, you might be missing early signs of disease that could be caught with more comprehensive testing. Discover why more advanced testing and functional lab tests are essential for detecting imbalances before they escalate into serious health issues, and learn how they can transform your practice and improve your clients' outcomes. Don't let overlooked tests put your clients at risk—find out how to catch warning signs early and effectively. Key Takeaways from This Episode: The limitations of conventional lab testing and standard test panels and how functional testing provides a more comprehensive view.How using functional lab testing can help practitioners identify health imbalances early, leading to better outcomes.Top lab tests that conventional medicine often overlooks, and how they impact metabolic health, cardiovascular health, and chronic disease risk.Real-world success stories that showcase how these tests transformed client care.Practical steps for health professionals to integrate functional testing into their practice for more personalized and preventative care. Key Terms in This Episode: Advanced Cardiovascular Markers - Lab tests such as ApoB and Lipoprotein (a) that assess deeper cardiovascular risks beyond standard cholesterol panels.Advanced Functional Medicine Tests - Certain testing methods give a more complete picture of micronutrient imbalances, gut health, and hormones than blood tests.Comprehensive Blood Sugar Testing- Comprehensive panels that assess blood sugar, insulin, and other markers that influence metabolic syndrome and type 2 diabetes.Thyroid Panel - Functional testing that looks beyond TSH levels, including T3, T4, antibodies tests, and more, for a more complete view of thyroid health.Resources For This EpisodeFree Resource - Guide to Using Genetic Testing to Optimize Patient OutcomesWatch and learn about lab testing for cardiovascular System from our 3-day practitioner event HEREDownload a comprehensive cardiovascular Lab testing guide and watch powerful presentations HERELearn more about Lipoproteins from our blog: Holistic Approaches to Lipoprotein Management: Beyond Statins and Medications

In the realm of nutrition science, few topics have sparked as much debate and evolution in understanding as the impact of dietary fat on cardiovascular health. Dr. Alice Lichtenstein, a renowned expert in nutrition and cardiovascular disease, brings clarity to this complex field. Her extensive research at several prestigious institutions has been pivotal in shaping contemporary dietary guidelines. Dr. Lichtenstein delves into the journey from early observational studies that linked high-cholesterol diets to cardiovascular risk to more nuanced insights emphasizing the types of fats consumed. The discussion highlights the critical shift from merely reducing total fat intake to replacing saturated fats with unsaturated fats, reflecting the latest evidence-based recommendations. Furthermore, the conversation addresses the variability in individual responses to dietary changes and the ongoing debate over the most accurate biomarkers for assessing cardiovascular risk. Dr. Lichtenstein also tackles the pervasive issue of nutrition misinformation and underscores the necessity of robust, evidence-based public health guidelines. This episode offers a comprehensive exploration of whole dietary patterns, the importance of examining food choices in context, and the role of public health policy in fostering healthier eating environments. Join us to gain a deeper understanding of how dietary fat influences health and the critical considerations for future nutrition research and recommendations. Timestamps: 03:15 Dr. Lichtenstein's Academic Background 05:47 Evolution of Dietary Fat Research 14:47 Understanding Cholesterol and Lipoproteins 23:47 Dietary Patterns and Public Health 29:51 Seed Oils & Nutrition Misinformation 34:06 Future Directions in Nutrition Research 47:11 Key Ideas Segment (Premium-only) Links: Subscribe to Sigma Nutrition Premium Go to episode page Receive our free weekly email: the Sigma Synopsis Enroll in the next cohort of our Applied Nutrition Literacy course

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in measuring the risk of cardiovascular disease. He explains how APO-B can penetrate the blood vessel wall and trigger an immune response, leading to the formation of plaque and potential heart attacks. Buck recommends keeping APO-B levels below 60 milligrams per deciliter to reduce the risk of atherosclerosis. He also mentions the importance of testing for lipoprotein little A (Lp(a)) levels, as high levels of Lp(a) are a major risk factor for atherosclerotic cardiovascular disease.

Commentary by Dr. Candice Silversides

In episode 529 of Sigma Nutrition Radio, we discuss all things related to cholesterol, atherosclerosis, heart disease, and dietary fat. The discussion extensively covers the impact of LDL cholesterol and ApoB on atherosclerotic plaque progression, cardiovascular events, and the benefits of early LDL lowering interventions, particularly through the use of PCSK9 inhibitors alongside statins. We address misconceptions prevalent in the low-carb and carnivore communities, dissect claims regarding saturated fats, and elucidate why atherosclerosis predominantly affects arteries and not veins. The episode sheds light on the nuanced mechanisms of cholesterol metabolism, the significance of different lipid particles, and the limited dietary impact on LP(a) levels. Comprehensive evidence-based insights and practical recommendations for dietary patterns and cardiovascular health interventions are provided, offering clarity on these complex topics. Note: This discussion is hosted by Simon Hill, and originally appeared as an episode of The Proof podcast. Links: Subscribe to Sigma Nutrition Premium Receive our free weekly email: the Sigma Synopsis Episode with Professor Chris Packard Timestamps: 07:19 Understanding Cholesterol and Lipoproteins 14:35 The Role of ApoB in Cardiovascular Risk 25:10 Atherogenic Lipoproteins and Their Impact 37:42 Causal Pathways and Biomarkers in Heart Disease 47:02 Understanding Residual Risk and Triglycerides 49:46 Paul Saladino's Claims on LDL and Metabolic Health 01:03:01 Addressing Concerns About Lowering Cholesterol 01:16:16 The Importance of Early Intervention in Cholesterol Management 01:23:36 The Future of Cholesterol Management and Gene Editing 01:28:24 Atherosclerosis in Arteries vs. Veins 01:36:08 Dietary Interventions to Lower ApoB Levels 01:47:55 Modifying Keto Diet for Better Health Outcomes 01:56:33 Plant-Based Diets and Fat Consumption 02:05:10 Understanding Lp(a) and Its Impact on Health Subscribe to Sigma Nutrition Premium

Episode #315. What is ApoB and why should you care? In this latest instalment of our masterclass series, I've distilled the essential insights about apolipoprotein B (ApoB) into one informative episode. Join top experts including Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho as they unravel the significance of ApoB as a crucial marker of cardiovascular health. This episode provides a thorough understanding of why ApoB matters and how it impacts your health. We unpack the essentials of ApoB, covering its role in cholesterol transport and why it's a key marker for heart disease risk. You'll learn how ApoB affects cardiovascular health, from the way it modifies LDL particles to its impact on atherosclerosis and longevity. We discuss the best ways to measure ApoB, its normal levels, and what causes it to rise. The episode also explores the relationship between ApoB and saturated fats, and why it's a more reliable risk marker than LDL cholesterol. By the end, you'll have a clear understanding of why ApoB matters for your heart health and how it can help guide better health choices. Specifically, we discuss: Introduction (00:00) Lipoproteins & Cholesterol: Transport and Recycling (00:43) Cholesterol's Role in Lipoproteins (26:40) Is ApoB a More Accurate Marker of Cardiovascular Risk? (31:13) Endothelial Transcytosis of Lipoproteins (39:42) LDL Modification and Aggregation (49:17) Evidence for ApoB's Role in Atherosclerosis (55:49) ApoB and Genetics (58:29) ApoB and Longevity (1:02:16) Mechanisms Behind Elevated ApoB Levels (1:05:14) Why ApoB is the Best Predictor of Cardiovascular Disease (1:08:52) ApoB vs LDL-Cholesterol: Understanding the Discordance (1:21:00) Healthy ApoB Levels for Young Adults (1:31:39) Causes of Elevated ApoB Levels (1:45:16) Target ApoB Levels for Cardiovascular Disease Prevention (2:04:31) The History and Evolution of the Lipid Hypothesis (2:07:27) Role of ApoB Lipoproteins in Atherosclerosis (2:10:21) Importance of ApoB as a Cardiovascular Risk Marker and Its Clinical Application (2:18:39) Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:27:47) Top Saturated Fat Foods That Increase Cardiovascular Risk (2:33:53) Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:35:49) Dietary Changes to Lower ApoB Levels (2:38:59) Outro (2:45:54) Read more about the guests featured on this episode or connect with them on their respective pages on The Proof website: Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you're currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet's best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Heart Health Month provides the backdrop for a timely discussion on the latest breakthroughs in treating cardiovascular disease. This is a rebroadcast of Dr. Michael Koren and Dr. Victoria Helow's examination of the sobering reality of heart disease statistics, the impact of statins, and the promising PCSK9 inhibitors on the horizon. We'll provide you with a snapshot of what you need to know about lowering dangerous LDL levels and the accessibility of cutting-edge treatments. By comparing the effects of lifestyle changes and medical interventions, we give you a well-rounded perspective on how to approach heart disease management.Rounding off our episode, we're on the cusp of a revolution in heart disease prevention with a semi-annual injectable targeting PCSK9. We're excited to discuss the prospects of this game-changing treatment, designed to offer long-term protection against high LDL cholesterol. The anticipation builds as we prepare to bring you the latest findings from the American College of Cardiology meeting in Atlanta. So stay with us, and together let's navigate the future of cardiovascular care, keeping you informed and heart-healthy for years to come.Talking Tips to Share:Understanding Lipid Issues and Cholesterol NumbersUnderstanding Lipoproteins and LDL LevelsBreakthroughs in Heart Disease TreatmentCholesterol, Lipoproteins, and Heart HealthInjectable PCS-K9 Vaccine Study PresentationRecording Date: February 21, 2024Be a part of advancing science by participating in clinical researchShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInWant to learn more checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Powered by ENCORE Research GroupMusic: Storyblocks - Corporate InspiredThank you for listening!

Join me on the Flex Diet Podcast as I sit down with the esteemed cardiologist Dr. Michael Twyman to tackle the vital subject of cardiovascular health and the power of early risk detection. We discuss the significance of functional testing and specific scans that could revolutionize your approach to heart disease prevention. Listen in as Dr. Twyman shares his transformation from invasive to preventative cardiology and learn about the essential tests he recommends for gaining invaluable insights into your heart health.For Dr. Twyman's top 4 takeaways, go to https://miketnelson.com/flex4. Special thanks to Flex Diet Podcast sponsor LMNT. Choose LMNT for all your hydration needs. Check out https://drinklmnt.com/mikenelson.Episode Chapters:(0:00:00) - Cardiovascular Health and Early Detection(0:06:22) - Cardiovascular Risk and Plaque Development(0:12:37) - Understanding Heart Health and Cholesterol(0:19:13) - Understanding Lipoproteins and Cardiovascular Health(0:27:54) - Functional Testing for Arterial Health(0:36:32) - Nitric Oxide and Arterial Health(0:44:18) - Understanding the Calcium Score Test(0:50:34) - The Importance of Circadian Rhythms(1:00:47) - Optimal Red Light Therapy Parameters Connect with Dr. Twyman:InstagramWebsite 

Fuzzy science” abounds in the world, and even luminaries fall into its trap sometimes. This review clarifies the mis-explanations of important concepts in lipid science that were discussed in Peter Attia's podcast. The interview with Dr. Thomas Dayspring resulted in a 7 hour series that promised a deep dive into cholesterol and lipoproteins. Lipid science is a complex and ever-evolving field. Understanding some of the basic tenets of the field helps us traverse more complicated topics. The intention of this review is to help clarify the important points Dr. Dayspring made and to open up the scope of the discussion by examining less considered aspects of cholesterol, lipoproteins and their functions. The deep dive into the topic by Drs. Attia and Dayspring was indeed much needed and appreciated and this review acts merely as supplementary commentary or footnotes to the discussion. Since Attia and Dayspring devoted an impressive 7 hours to their discussion, the 2 hour length in this episode respects the time and effort that went into their series by attending to their points in detail. Let me know your thoughts in the comments. What questions do you have from Dr. Dayspring's interview?Time stamps: 00:00 Intro 05:11 Criteria for review 06:53 Aligning with their intention 09:29 Feynman's scientific principles 11:28 Phospholipids 18:46 Lipid Rafts 30:54 TD: "All cells make cholesterol." 45:28 The Rare Exceptions 50:45 Lipoproteins & cholesterol in artery walls 1:05:59 Pools of Cholesterol 1:09:50 Lipoprotein density1:12:23 How apoproteins are bound 1:15:04 Statins & liver selectivity 1:21:05 Cholesterol functions & metabolism 1:31:02 HDL 1:34:11 RBC membrane cholesterol 1:36:59 Lipoprotein lineages 1:40:48 ApoE 1:50:40 Cholesterol's function in lipoproteins 1:59:55 Unregulated apoB 2:02:23 Conclusion  My practice: https://vyvyanelohmd.com/work-with-me/

Dave Champion, Ph. D. is a returning guest on our show! Be sure to check out his first appearance on episode 121, and his second appearance on episode 358 of Boundless Body Radio! Dave Champion is a former Army Ranger with a law enforcement background. In the private sector, Dave is a businessman turned journalist, having hosted his own radio and television shows from 2000 through 2018. In addition to being a physiologist, with a doctoral degree in Political Philosophy, Champion has an extensive background in legal studies. Dave has written the groundbreaking and widely acclaimed Income Tax: Shattering The Myths. His second book Body Science: The New 21st Century Understanding Of How Your Physiology Really Works, Leave The Myths And Lies Behind, Get Healthier Than You (Or Your Doctor) Ever Imagined And Avoid Chronic Disease.is the result of his research into the core principles of human physiology, leading to a visionary understanding of how every person on the planet can get healthy, stay healthy, and reduce their odds of getting a diagnosis of a chronic disease to virtually zero. It is one of my favorite books on the subject, and will be the topic of our discussion today!Find Dave at-https://drreality.news/Book- Body ScienceTW- @DrReality5 Rumble- @Dave Champion, Ph. D.FB- Busy Keto Life with Dr. Dave ChampionFind Boundless Body at- myboundlessbody.com Book a session with us here!

ไลฟ์#68: Lipoprotein particles ชนิดใดบ้างที่อันตรายต่อหลอดเลือดหัวใจ น้องๆมักจะได้ยิน กูรูสุขภาพ เตือนให้เราระวังอันตรายจาก small dense ldl particle บอกว่าเป็น ldl particle ที่เป็นอันตรายต่อหลอดเลือดหัวใจ การเปลี่ยนมากินอาหารแบบคาร์บต่ำไขมันสูง จะทำให้ ldl-particle มีขนาดใหญ่ ไม่เป็นอันตรายต่อหลอดเลือดหัวใจ และให้เราสนใจสัดส่วน TG/HDL ถ้าใกล้เคียง 1 นี่ถือว่าปลอดภัย ไม่ต้องสนใจระดับ total cholesterol และ ldl-cholesterol ที่สูงลิ่ว….จริงหรือ ในไลฟ์#68 เราจะมาทำความเข้าใจกันว่า lipoprotein particles ชนิดใดบ้าง ที่อันตรายต่อหลอดเลือดหัวใจ เราควรสนใจแต่ small dense ldl particle จริงหรือ นอกจากนั้นมาฟังประธาน European Atherosclerosis Society คนปัจจุบัน ซึ่งเป็นแพทย์ผู้เชี่ยวชาญโรคหัวใจ/lipidologist มา 30 ปี ให้สัมภาษณ์พูดถึงสัดส่วน TG/HDL ว่า เป็น parameter ที่ใช้ในการทำนายความเสี่ยงของโรคหลอดเลือดหัวใจได้จริงตามที่ กูรูสุขภาพ ชวนเชื่อเราจริงหรือ งานวิจัยอ้างอิงในไลฟ์#68: Lipoproteins ชนิดใดบ้างที่อันตรายต่อหลอดเลือดหัวใจ 1. Low-density Lipoprotein Particle Number and Risk for Cardiovascular Disease https://moscow.sci-hub.st/817/60bd012... 2. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review by Allan D. Sniderman https://www.ncbi.nlm.nih.gov/pmc/arti... 3. LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA) https://pubmed.ncbi.nlm.nih.gov/16765... 4. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel https://academic.oup.com/eurheartj/ar... 5. Therapeutic Lipidology Chapter 27: Lipoprotein Subfractions in Clinical Practice by Jeffrey W.Meeusen https://link.springer.com/chapter/10.... 6. Metabolism and atherogenicity of apoB containing lipoproteins EAS https://eas-society.org/content/metab...#หาคำตอบสุขภาพจากงานวิจัยไม่ใช่จากเรื่องเล่า #FatOutHealthspans

Introduction to lipoproteins and what they do. Not all HDL are good, not all LDL are bad. https://dralo.net/links

TWiM reviews how a coating of lipoproteins provides a stabilizing environment on the inner membrane of Bacillus subtilis spores, and a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track mediators of inflammation in the gastrointestinal tract Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email. Become a patron of TWiM. Links for this episode Lipoproteins stabilize germination apparatus (J Bacteriol) A coating of liposomes (J Bacteriol) Biosensor to detect inflammatory molecules in the gut (Nature) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

This week on ReInvent Healthcare, I talk about a topic that not very many practitioners talk about these days - Lipoprotein A. I'll go in depth on how it affects the cardiovascular system, the genetic factors involved, testing that we can do, as well as some approaches for lifestyle and diet choices that can help bring down Lipoproteins. IN THIS EPISODE:Understanding the Significance of Lp(a)The Lp(a) is a lipoprotein particle in the bloodstream that is an independent risk factor for cardiovascular disease that resembles LDL cholesterol but is denser and even more dangerous. It can easily pass into the inner lining of blood vessels, leading to plaque formation, inflammation, increased clotting, and an increased risk of heart attacks, strokes, and aortic stenosis. We need to be knowledgeable about its characteristics, its role in plaque formation, inflammation, and clotting within blood vessels, and how it can lead to heart attacks, strokes, and aortic stenosis. The Role of Genetic FactorsElevated Lp(a) levels are estimated to be 90% hereditary, making it crucial to assess genetic risk factors. Certain genetic variants linked to Lp(a)are associated with a shorter lifespan and a higher risk of aortic stenosis. We should consider genetic testing, especially in individuals with a family history of heart disease, to assess the presence of Lp(a)-related genetic variants. Dietary and Supplemental ApproachesWhile there is no consensus on the best diet for heart disease, a whole foods diet rich in antioxidants, combined with specific supplements like niacin, ginkgo biloba, berberine, vitamin C, and L-carnitine, can potentially lower Lp(a) levels and improve overall cardiovascular health. Individualized approaches are essential, and regular testing is recommended to monitor progress and adjust interventions as needed. ReInvent Healthcare Links Get our FREE Guide to Taking a Detailed Health History that gets you to root causes.Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training. Visit my ReInvent Healthcare site to check out other episodes that will be beneficial to you and your clients.

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. Part 2 will drop as Episode 22. 0:01:31 - What exactly is a Cardio IQ? 0:03:15 - the cost of Cardio IQ 0:05:18 -Lipid panel, Total Cholesterol, HDL, Triglycerides, LDL Cholesterol 0:08:29 - HDL the so-called good cholesterol 0:13:55 - Lipoproteins 0:15:42 - LDL Particle Number 0:22:46 - Apolipoproteins 0:25:40 - Apolyte protein tag 0:27:48 - Apolipoprotein B or apoB 0:28:31 - Lipoprotein(a) or Lp(a) 0:31:41 - Statins: Crestor and Livalo 0:32:41 - How do Statins work? 0:33:11 - Repatha 0:36:58 - Inflammation and Atherogenesis 0:39:39 - High-sensitivity C-reactive protein (hsCRP) 0:40:43 - Lp-PLA2 activity  0:41:43 - Oxidative LDL 0:42:04 - Myeloperoxidase enzyme 0:45:07 - F2-isoprostanes as a marker of risk

Reference Dr Guerra: Graduate Biochemistry lecture material. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

Links: Go to episode page (with resources) Subscribe to Sigma Nutrition Premium Receive our free weekly emails Introduction: Discordance between low-density lipoprotein particle (LDL-p) and low-density lipoprotein cholesterol (LDL-C) occurs when the levels of these two biomarkers do not match up as expected. Discordance between Apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) is similar, except rather than counting just LDL particles, ApoB is a measure of the numbers of lipoproteins that have an ApoB attached. Discordance between ApoB and LDL-C can lead to either an underestimate or overestimate of ASCVD risk. And therefore there may be important implications for someone who does have discordance. Additionally, it is such cases that suggest that a measurement of ApoB may provide additional information beyond traditional lipid measures in assessing a person's cardiovascular risk. Recent work from researchers at Liverpool John Moores University has investigated whether discordance is associated with certain dietary patterns. In this episode, one of the researchers involved, Dr. Ian Davies, is on the podcast to discuss this work in addition to wider questions in the diet-lipids-CVD field that remain to be answered.

Episode #251. Cardiovascular disease is one of the biggest killers in the Western world, and it's vital that we understand cardiovascular health in order to improve lifespan and healthspan. In this episode, I sit down with Dr Thomas Dayspring for Part One of a three-part deep dive into cardiovascular disease and blood lipids. In this introductory episode, we examine how our body absorbs lipids and transports them throughout the body – and what happens when it goes wrong. Specifically, we discuss: Intro (00:00) Turning a family heartache into a mission (05:12) Atherosclerosis and the role of lipids (14:52) Lipoproteins & cholesterol transport and recycling (28:01) Cholesterol's role in lipoproteins (54:00) Is ApoB a more accurate marker of cardiovascular risk? (58:38) Endothelial transcytosis of lipoproteins (1:07:10) LDL aggregation (1:16:42) LDL particle retention and inflammation (1:23:15) Difference between veins and arteries (1:28:55) Atherosclerosis and genetics (1:30:22) High-fat diets and cholesterol (1:44:01) Fiber and cholesterol absorption (1:48:14) Outro (1:57:48) The best place to connect with Dr Thomas Dayspring is on Twitter, @DrLipid. Learn more about Dr Dayspring's career and current work on LinkedIn. Discover more insights and supporting studies in the full show notes. To assist with the digestibility of this content my team and I, along with Dr Dayspring, have added a bunch of illustrations and graphs to the video format of these episodes. So if you are visually inclined you can watch these episodes on our YouTube channel. Even if you prefer listening to the first time through audio, I highly recommend coming back for a second pass with the video versions.  We've also got a Summary PDF being created with the key learnings from each part of the series. To receive a copy of this simply submit your email at theproof.com/lipidseries.  And we are working on transcripts for these episodes too (release date TBC).  Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary two-week meal plan and high protein Plant Performance recipe book

Lipoproteins are a transport system for fats in the body. Certain classes of them have been implicated in atherosclerosis. We'll cover an overview on lipoproteins as they are commonly discussed in the medical world and also answer certain basic questions such as where small dense LDLs come from and what is oxidized in OxLDL?For more information visit http://www.VyvyaneLohMD.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.08.527629v1?rss=1 Authors: Ehring, K., Ehlers, S. F., Froese, J., Gude, F., Puschmann, J., Grobe, K. Abstract: The Sonic hedgehog (Shh) signaling pathway controls embryonic development and tissue homeostasis after birth. This requires regulated solubilization of dual-lipidated, firmly plasma membrane-associated Shh precursors from producing cells. Although it is firmly established that the resistance-nodulation-division transporter Dispatched (Disp) drives this process, it is less clear how lipidated Shh solubilization from the plasma membrane is achieved. We previously showed that Disp enhances proteolytic Shh solubilization from its lipidated terminal peptide anchors. This process, called shedding, converts tightly membrane-associated hydrophobic Shh precursors into delipidated soluble proteins. We show here that Disp-mediated Shh shedding is modulated by a serum factor that we identify as high-density lipoprotein (HDL). In addition to serving as soluble sinks for free membrane cholesterol, HDLs also accept the cholesterol-modified Shh peptide from Disp. The cholesteroylated Shh peptide is required and sufficient for Disp-mediated transfer because mCherry linked to cholesteroylated peptides associates with HDL in a Disp-dependent manner, but an N-palmitoylated Shh variant that lacks C-cholesterol does not. Disp-mediated Shh transfer to HDL is finalized by proteolytic processing of the palmitoylated N-terminal membrane anchor. The resulting mono-lipidated Shh variant may help meet the demands for Hh activity regulation in different cell types and developing tissues. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode, Dr. Stephen Kopecky, M.D., Preventative Cardiologist at @MayoClinic, gives us the scoop on lipoprotein (a) and how it can lead to heart disease. Order his book, Live Younger Longer, at: https://mcpress.mayoclinic.org/shop/healthy-aging-books/living-younger-longer/ Dr. Kopecky answers questions like: *What is lipoprotein (a)? *How does lipoprotein (a) lead to heart disease? *How do you see if you have high levels of lipoprotein (a)? *How do you avoid an excess of lipoprotein (a)? *How do you get lipoprotein (a)? *Are there any treatments to lower your lipoprotein (a) levels or inhibit its effects? Live Younger Longer Podcast | Episode 17 Subscribe to Dr. Kopecky's podcast, Live Younger Longer: Listen on Spotify: https://open.spotify.com/show/1NpjRShXrApylcGP5H9gvX Listen on Apple Podcasts: https://podcasts.apple.com/us/podcast/live-younger-longer/id1629548282 Watch the rest of the episodes here: https://youtube.com/playlist?list=PL-0wPfZ2Y6IYK0Tt924Ugr_urYP_80LOO You can pick up your copy of his book, Live Younger Longer, at: https://mcpress.mayoclinic.org/shop/healthy-aging-books/living-younger-longer/

Check out our new Patreon page! Get access to the Boundless Body Radio Premium Podcast, with a new episode added every other week! Other perks include early releases of our episodes, extended video content, and group and one on one coaching!Dave Champion, PhD is a returning guest on our show! Be sure to check out his first appearance on our podcast on episode 121 of Boundless Body Radio! Dave Champion is a former Army Ranger with a law enforcement background. In the private sector, Dave is a businessman turned journalist, having hosted his own radio and television shows from 2000 through 2018. In addition to being a physiologist, with a doctoral degree in Political Philosophy, Champion has an extensive background in legal studies. Dave has written the groundbreaking and widely acclaimed Income Tax: Shattering The Myths. His second book Body Science: The New 21st Century Understanding Of How Your Physiology Really Works, Leave The Myths And Lies Behind, Get Healthier Than You (Or Your Doctor) Ever Imagined And Avoid Chronic Disease.is the result of his research into the core principles of human physiology, leading to a visionary understanding of how every person on the planet can get healthy, stay healthy, and reduce their odds of chronic disease to virtually zero. It is one of my favorite books on the subject, and will be the topic of our discussion today!Find Dave at-https://drreality.news/Book- Body ScienceFB- Busy Keto Life with Dr. Dave ChampionDave's CAC Score Video on YouTubeFind Boundless Body at-myboundlessbody.comBook a session with us here! Find Boundless Body at- myboundlessbody.com Book a session with us here! Check out our new Patreon page!

In this interview, Andrea talks to Dr. Jonny Bowden, author of over 15 health books, including "The Great Cholesterol Myth, Revised and Expanded" and "Living Low Carb." Jonny Bowden has a Ph.D. in Holistic Nutrition and is a Certified Nutrition Specialist. Here are some of the topics they cover.00:50 Introduction01:20 Cholesterol 101-how it was measured with HDL and LDL measurements and why it's important to use new testing NMR Particle Test07:10 Lipoproteins, their relationship to cholesterol and plaque in the arteries09:08 The many types of cholesterol outnumber the two commonly talked about and measured, HDL and LDL10:45 How to advocate for yourself and what to ask for to test your cholesterol12:20 The main predictor of heart disease14:25 How little conventional doctors know about nutrition and prevention 16:20 Why cholesterol matters in menopause, especially when LDL rises, and its relationship to estrogen26:00 Triglycerides to HDL ratios and their importance in predicting heart disease29:10 Insulin resistance and root causes of chronic conditions31:26 Insulin resistance is treatable and reversible with diet, exercise, and lifestyle32:56 Is eating fat making us fat?35:00 The most important nutrition advice everyone needs to follow38:27 Supplements you can benefit from-Vitamin D3 + K2, Magnesium, Fish Oil, Multivitamin, and Multi-mineral with selenium and zinc, probiotics, and tocotrienols.Also recommended by Jonny during the podcast:The Cancer Code by Dr. Jason FongWhy We Get Sick by Benjamin Bikman, Ph.D.Jonny's Free Course-The Five Day Challenge-Intermittent FastingEpisode #40: The Best and Worst Oils for Your Health with Dr. Jonny BowdenVisit wearemorphus.com to learn more about the signs and symptoms you may be experiencing, and read our latest articles on perimenopause and menopause.Join our Wearemorphus PRIVATE group here: https://bit.ly/2MsxBBf ====== 

Dr. William Cromwell specializes in the diagnosis and management of lipid (cholesterol and triglyceride) and metabolic disorders. In addition to 30 years of clinical practice experience, his career includes 14 years of service as Medical Director / Division Chief of Lipoprotein and Metabolic Disorders at multiple institutions, 6 years as Chief Medical Officer of one of the world's most innovative lipoprotein diagnostic companies, LipoScience, and 4 years as Strategic Director / Discipline Director of Cardiovascular Disease at LabCorp. Throughout this journey, his motivation has been to create strategies that optimize patient-specific care. This is a significant challenge in the current health care environment. Find Dr. Cromwell: https://precisionhealthreports.com/bio/wcromwell Timestamps 00:00 Lipoproteins 04:09 Atherogenic lipoproteins, APO-B 06:52 Cholesterol not a good marker of cardiovascular risk 19:11 Plaques in young adults 23:03 Low-carb diets not making a difference in some people 25:13 LDL-skeptic 29:48 APO-B, APO-A relationship 33:34 HLD vs LDL 34:39 Glycation damage 37:50 Different types of plaque and thrombosis 41:29 CAC score pros and cons 48:06 APO-B better measure than LDL 50:29 Genetic vs therapeutic answer 56:11 PCSK-9 function 59:01 Precision Health Reports See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Book a Carnivore Coach: https://carnivore.diet/book-a-coach/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation #humanfood #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree ‪ Dr. William Cromwell specializes in the diagnosis and management of lipid (cholesterol and triglyceride) and metabolic disorders. In addition to 30 years of clinical practice experience, his career includes 14 years of service as Medical Director / Division Chief of Lipoprotein and Metabolic Disorders at multiple institutions, 6 years as Chief Medical Officer of one of the world's most innovative lipoprotein diagnostic companies, LipoScience, and 4 years as Strategic Director / Discipline Director of Cardiovascular Disease at LabCorp. Throughout this journey, his motivation has been to create strategies that optimize patient-specific care. This is a significant challenge in the current health care environment. Find Dr. Cromwell: https://precisionhealthreports.com/bio/wcromwell Timestamps 00:00 Lipoproteins 04:09  Atherogenic lipoproteins, APO-B 06:52 Cholesterol not a good marker of cardiovascular risk 19:11 Plaques in young adults 23:03 Low-carb diets not making a difference in some people 25:13 LDL-skeptic 29:48 APO-B, APO-A relationship 33:34 HLD vs LDL 34:39 Glycation damage 37:50 Different types of plaque and thrombosis 41:29 CAC score pros and cons 48:06 APO-B better measure than LDL 50:29 Genetic vs therapeutic answer 56:11 PCSK-9 function 59:01 Precision Health Reports See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Book a Carnivore Coach: https://carnivore.diet/book-a-coach/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation   #humanfood #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree  ‪

This week we're going to go straight to the HEART of the matter.LITERALLY.I have been searching for answers about HEART HEALTH for a long time now.  Those of you who follow me on a regular basis know I have some heart issues.  So not only is this going to be a great download about heart health for you, but it's also an especially personal episode for me as well.That's because this week's guest saved my life.Let me repeat that…SHE SAVED MY LIFE!Just as important, since HEART DISEASE is a leading cause of death worldwide, what you hear this week will impact you and many people you know.And what you'll learn could SAVE YOUR LIFE too.My guest, DR. AMY DONEEN, is an internationally recognized leader in the prevention of HEART ATTACKS, STROKES, AND DIABETES and is the owner and medical director of The Heart Attack & Stroke Prevention Center (HASPC) in Spokane, Washington.  Dr. Doneen is also the co-founder and a principal instructor in the BaleDoneen Method, a genetically guided, precision-medicine approach to preventing, detecting, and treating cardiovascular disease.  And she has written a must-read book, HEALTHY HEART, HEALTHY BRAIN.I GUARANTEE you'll think differently about your heart health after listening to this week's episode.Dr. Doneen wastes no time in giving you practical information about life-threatening symptoms you should watch for.  We spend time talking about……the RED FLAGS for a heart attack…why the right BLOOD PRESSURE is critical for long-term health…the role of CHOLESTEROL and LIPOPROTEINS in your body…what FAT DEPOSITS in the eyes mean…and the connection between ORAL and ARTERIAL HEALTHYou're going to get an important BIOLOGY LESSON on how all your vital organs and body systems work in concert with each other.  Dr. Doneen is going to teach you about your ARTERIAL HIGHWAY SYSTEM, how PSYCHOSOCIAL HEALTH AND BRAIN HEALTH are linked, and why it's important for those systems to function well so that you can improve your heart health.Is there a DOCTOR IN THE HOUSE this week?ABSOLUTELY!And her message is simple…If you want to LIVE LONGER, learn about your heart, and take care of it like your life depends on it.Because…it does.

Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today's conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more. If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld ETHAN WEISS LINKS: Website: https://profiles.ucsf.edu/ethan.weiss Twitter: https://twitter.com/ethanjweiss LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Welcome to Live Longer World 0:44 Misconceptions of heart disease / young people with heart disease 4:01 Predictors of heart disease 6:59 LDL vs HDL; Triglycerides 12:51 Small-dense LDL vs. Large fluffy LDL 16:09 Dietary Carbohydrates & heart disease risk 25:50 Inflammation & Cardiovascular risk 26:43 Lipoproteins, ApoB, Lp(a) 31:31 Statins, PCSK9 inhibitors 32:45 ApoB as gold standard risk marker 36:50 Triglycerides & Insulin resistance 40:00 Saturated Fat 42:42 Variation in Cholesterol measurement 46:03 Body composition as marker for heart disease risk 51:23 Ketogenic diets & heart health 56:43 Keyto breath sensor 1:01:46 Stress & heart disease 1:04:44 Growth hormone & heart disease 1:07:46 On the shortness of life 1:10:52 Support & Connect with Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Do you worry about your clothing size or whether your butt looks too big or not big enough? (hello everchanging and unrealistic beauty standards). Let's take a look at some of the numbers that REALLY matter. On this episode, Dr Sarah explains what your insulin, glucose and cholesterol levels should be. Come for the juicy science, stay for the nickname Sarah once gave her liver in Med School. The information in this podcast is for general use, always consult your doctor or physiotherapist before undertaking a new exercise program. Contact us:womenlikeyoupodcast@gmail.com WLY resources and recommendations: AusDRisk calculator https://www.health.gov.au/resources/apps-and-tools/the-australian-type-2-diabetes-risk-assessment-tool-ausdrisk Aerobic exercise and lipids and lipoproteins in women: a meta-analysis of randomized controlled trialshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447858/pdf/nihms34518.pdf WLY newsletter subscription  The Women Like You podcast is recorded on the lands of the Gadigal people of the Eora nation. We pay our respects to elders past, present and emerging. We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the land where we live, work, and exercise. See omnystudio.com/listener for privacy information.

Malonyl CoA controls the categorical/biochemical logic of hepatic glucose and lipid homeostasis via metabolic inhibition of metabolic antimony. References Dr Dan Guerra Biochemistry Lecture Notes. 2010-2021 Vance and Vance Biochemistry of Lipids, Lipoproteins and Membranes 4th ed. 2002. Elsevier Publisher. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Alzheimer's disease and dementia prevalence and deaths are on the rise, claiming over 6,000 lives in the USA every week! Yet many people don't even know their APOE genotype, which arguably has the biggest impact on future Alzheimer's disease and dementia as well as cardiovascular disease risk. In this show we dive deeper into what the APOE gene does and how knowing this info can help tweak your nutrition and lifestyle helping to reduce risk of future disease—especially if you have one or two copies of the APOE ε4 gene. Save on your Omega-3 Index Test by MYOXCIENCE Nutrition: http://bit.ly/omega-3-index Use code Podcast at checkout Link to Video + Show Notes: https://bit.ly/apoe-gene-alzheimers Eat Like Your Life Depends on it Tee Shirt: http://bit.ly/myoxcience Enroll in the Blood Work MasterClass: https://bit.ly/blood-work-masterclass Time Stamps: 0:00 Intro 00:53 APOE is a gene that makes proteins that are involved in lipid binding. 01:10 APOE and Immunity 01:39 APOE 4 alleles and Alzheimer's disease risk 03:13 3 different APOE isoforms: APOE2, APOE3, APOE4 allele. 03:44 Having the gene does not mean that you will get the disease. 04:35 APOE is involved in lipid metabolism 05:30 Lipoproteins and lipids transport 06:05 APOE can redistribute lipids across tissues and cell types. 07:40 APOE is secreted by the liver with VLDL and bile acids 08:00 Lipoprotein lipase facilitates your metabolic deposits. Hormone sensitive lipase facilitates your metabolic withdrawals. 09:42 Your omega 3 index and APE 4 isoform. 11:35 APOE4 and cholesterol 11:45 ApoB VS ApoE 12:09 APOE2 carriers tend to have a less atherogenic lipid profile. 12:15 APOE4 carriers are associated with decreased levels of APOE triglycerides and increased levels of APOB in lipoproteins 13:12 APOE4 puts genotype carriers at increased risk for heart disease. This is likely due to the association with APOE4 and elevated LDL and Apolipoprotein B. 14:07 APOE4 primes your microglia to be more inflammatory. Microglia are brain immune cells. They are involved in synaptic processing, pruning of cells, shaping neurons, and removing inflammatory debris. APOE4 carriers have decreased cerebral glucose metabolism and increased levels of beta amyloid and tau protein. 15:50 With APOE4, there are changes and increase of tau protein within the neurons. There are also alterations in the blood brain barrier integrity. 16:00 To preserve the integrity of the brain, moderate alcohol consumption, increase exercise, incorporate sauna therapy and sauna bathing, as it effects cerebral blood flow. 16:45 APOE is expressed in astrocytes, microglia and other vascular cells within the brain. Blood brain barrier prevents toxins and metabolic waste from going into your brain. Increased expression of APOE is detected in stressed neurons. 17:42 APOE isoforms affect lipid transport, glucose metabolism, mitochondrial function, synaptic plasticity, beta amyloid protein expression, tau protein and cerebral vascular function within the brain. 18:18 Ratio of APOE4 allele correlates with loss of gray matter volume and abnormal glucose metabolism, a hallmark of Alzheimer's and dementia. 19:00 APOE4 is the greatest genetic risk factor for late onset Alzheimer's disease. It also influences the risk and outcomes for stroke, MS, Parkinson's disease, and frontotemporal dementia. 22:11 A low carb diet, high in wild caught fish, is protective for APOE4 carriers. It impacts brain metabolism and lipid levels favorably. Drive your glycemic load down. 24:05 If you are over the age of 50 and have one or two copies of the APOE4 allele, consider microdosing with rapamycin. Rapamycin is an mTOR inhibitor. It may delay the onset of Alzheimer's and dementia.

Commentary by Dr. Valentin Fuster

Several new therapeutic drug classes are now available to manage lipid levels. John Wilkins, MD, MS, and Donald Lloyd-Jones, MD, ScM, of the Department of Preventive Medicine and Division of Cardiology at Northwestern University Feinberg School of Medicine, discuss the use of ezetimibe, PCSK-9 inhibitors, bempedoic acid, and icosapent ethyl to manage lipid levels in patients taking statins who require additional LDL lowering. Related Content: Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk Lipids and Lipoproteins in 2020

Dave Champion, Ph. D. caught my attention when he reached out to see if I'd like to read his book, Body Science. I did, and I found it to be a treasure. Dave does an incredible job describing the cholesterol and fat delivery systems in the body. If you or anyone you love needs answers to their questions about cholesterol, dietary fat, longevity, and chronic diseases, this is a must-listen! Please check out his book, Body Science, and continue researching this topic if you want more information! It couldn't be more important, and we are so grateful for Dave and his work!Find Dave at-https://drreality.news/Book- Body ScienceDave's CAC Score Video on YouTube

Cardiovascular, or heart, disease is the leading cause of death in America. Dr. Anthony Patrello discusses what the risks of heart disease are and how they are determined.

CardioNerds Academy Chief Fellows Dr. Rick Ferraro (FIT, Johns Hopkins) and Dr. Tommy Das (FIT, Cleveland Clinic) join Academy fellow Dr. Jessie Holtzman (soon, chief resident at UCSF internal medicine residency) to learn all about LDL physiology and function from Dr. Peter Toth! Low-density lipoprotein cholesterol (LDL-C) has been well established as a risk factor for atherosclerotic cardiovascular disease with an ever growing armamentarium of medications to lower LDL-C plasma levels. Yet, LDL-C also plays a number of key physiologic roles across mammalian species, such as cell membrane formation, bile acid synthesis, and steroid hormone production. In this episode, we discuss the definitions of high, normal, low, and ultra-low LDL-C, what functional assays are used to measure LDL-C, and what is considered the safe lower-limit of LDL-C, if there is one at all. Drawing upon experience from rare genetic conditions including abetalipoproteinemia and loss-of-function variants of the PCSK9 gene, we glean pearls that clarify  the risks and benefits of low LDL-C. Pearls • Quotables • Notes • References • Guest Profiles • Production Team CardioNerds Lipid Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls 1. Lipoproteins are processed via two major pathways in mammals: 1) exogenous fat metabolism that digests ingested lipids and 2) endogenous fat metabolism that synthesizes lipids in the liver and small intestine. High density lipoprotein (HDL)-mediated reverse transport also brings lipids from the periphery back to the liver. 2. LDL-C comprises ~70% of plasma cholesterol due to its long half-life of 2-3 days. It is one of 5 major lipid particles in plasma including chylomicrons, very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), LDL, and HDL. The liver degrades 40-60% of LDL, while no other tissues in the body make up more than 10% of LDL. LDL-C is energy-poor and cholesterol rich, such that peripheral tissues may not utilize these particles as a fuel source. 3. Preserved functions of LDL-C across mammalian species include cell membrane formation, bile acid synthesis, and steroid hormone production. In other mammalian species, LDL-C levels are found in the 35-50 mg/dL range (Way lower than found in the general human population, and likely more representative of baseline human physiology!). 4. Large, randomized control trials do not consistently demonstrate major adverse effects associated with lower serum LDL-C levels, including risks of cognitive decline, hemorrhagic stroke, reduced bone density, or impaired immune function. 5. Initiation of, and education on LDL-lowering therapy remains insufficient, both in terms of long-term adherence to therapy and achieving current guideline directed goals of LDL-C

To crack the causes of metabolic disease, Dr. Changting Xiao is peering into the "black box" of the human gut. As a boy, Xiao frequently ran homemade experiments, trying to figure out how systems work. Over the decades that followed, he observed an 'epidemic' increase in diabetes, obesity, strokes and heart disease. In this episode, the biomedical researcher explains why he recently moved to Saskatchewan, and his fascination with the human gut, and its role in creating 'bad blood fats'. "The gut is often overlooked and often under-studied," Xiao said. "The gut is very smart and complex, and there is much more to be learned."

In order to interpret your cholesterol tests, we need to understand lipoproteins. If fats and oils are released into the bloodstream, they would cause major damage if not for lipoproteins. Fats and oils would coalesce into large "bubbles" or emboli. These emboli would cause damage like heart attack if not controlled. Lipoproteins keep the fats and oils from forming large, or embolic, particles.  LDL (low-density lipoprotein) and HDL (high-density lipoprotein) are mostly the same except for the portion of protein. HDL has 50% or more protein. LDL has 25% or less protein. HDL is, therefore, like an empty dump truck, able to carry LDL away from the artery wall. LDL is like a full dump truck, spilling and leaving LDL in the lining of the arteries. That LDL deposition is plaque formation.  Other particles (lipoprotein) get larger and are carry even more fats and oils. These are called IDL (intermediate density lipoprotein) and VLDL (very low density lipoprotein) all have more fats and oils (cholesterol and triglycerides). The particles that are the most likely to get caught in the artery wall have mostly fat (LDLs), but they are small & dense enough to slip between cracks in the intima. They're called sdLDL, which stands for small, dense LDL. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's article on cardiovascular inflammationPrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

Dr. Nadir Ali, an interventional cardiologist clears up confusion about LDL and answers questions like is LDL cholesterol really bad for us? Why does LDL cholesterol go up on a low carb diet? Are statins bad for you? Do statins prevent or cause heart disease?As a leading cardiologist in the high fat, low carb space, Dr. Nadir Ali has been paving the way in advocating that we should not fear high LDL cholesterol when other numbers are in line such as low triglycerides, low insulin and glucose, low inflammation, and high HDL cholesterol.Statins are commonly prescribed for elevated LDL cholesterol but as Dr. Ali discusses in this video, we may be treating high LDL all wrong. Statins have been shown to have significant side effects like cognitive and memory problems, fatigue, and muscle pain for many patients. Elevated LDL has been shown to be important for sex hormones, muscle function, cognition, and inflammation. Tune in for a very informative episode and be sure to share this with someone (even your healthcare provider) who may need to hear it!CoachingIf you’re ready to lose the weight for good, you’ve come to the right place!Join my online course, Weight Loss for Health, to learn the science behind weight loss and habit change so you can lose weight, get healthy, and prevent disease. Also included with the program are weekly office hours with me and a membership site for encouragement, accountability, and support from other members. To learn more, go to https://www.weightlossforhealth.com/join.Free Weight Loss ResourcesWeight Loss Masterclass to Lower Insulin Resistance & InflammationThe 5% Mindset | How to Win at Weight LossThe Ultimate Food Guide | What to Eat to Burn FatConnect on Social>> Subscribe to My YouTube Channel>> Like My Facebook Page>> Follow Me on Instagram>> Connect on LinkedIn>> View My WebsiteSubscribe & Review in Apple PodcastsAre you subscribed to my podcast? If you’re not, I want to encourage you to do that today. I don’t want you to miss an episode. Click here to subscribe in Apple Podcasts.Now if you’re feeling extra loving, I would be really grateful if you left me a review over on Apple Podcasts, too. Those reviews help other people find my podcast and they’re also fun for me to go in and read. Just click here to review, select “Ratings and Reviews” and “Write a Review” and let me know what your favorite part of the podcast is. Thank you!

This episode goes deep on something called cardiometabolic risk, understanding lipoproteins and metabolic disorders. I’m here with Dr. William Cromwell, who is the chief of the Lipoprotein and Metabolic Disorders Institute in Raleigh, North Carolina, and who is one of the foremost experts in the world on these topics. I think this is a really …

This episode goes deep on something called cardiometabolic risk, understanding lipoproteins and metabolic disorders. I’m here with Dr. William Cromwell, who is the chief of the Lipoprotein and Metabolic Disorders Institute in Raleigh, North Carolina, and who is one of the foremost experts in the world on these topics. I think this is a really …

This episode goes deep on something called cardiometabolic risk, understanding lipoproteins and metabolic disorders. I’m here with Dr. William Cromwell, who is the chief of the Lipoprotein and Metabolic Disorders Institute in Raleigh, North Carolina, and who is one of the foremost experts in the world on these topics. I think this is a really …

Commentary by Dr. Valentin Fuster

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 am to 10 pm EST. Saturday & Sunday from 9 am to 6 pm EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - http://bit.ly/3nHbNTs • Plain (Unflavored) - http://bit.ly/3as0x9U Take Dr. Berg's Free Keto Mini-Course! I interview Dave Feldman, who has mastered the understanding of cholesterol. The second “L” in LDL stands for lipoprotein, and it's actually like a boat that carries cholesterol throughout your body and not the cholesterol itself. Your body makes cholesterol because it needs it for health. Cholesterol is in every cell in your body, and you couldn't function without it. Dave has demonstrated many times that LDL will often drop in response to a high-fat diet, though a small subset of people may experience a dramatic increase, as Dave did. When he deliberately gained 20 pounds of body fat, though, his LDL dropped down to a normal level. As well, populations with low triglycerides and high HDL (high-density lipoproteins) cholesterol have reduced the risk of cardiovascular disease and all-cause mortality. Lipoproteins carry not only cholesterol, but triglycerides, fat-soluble vitamins, and antioxidants. Everything your cells need that's not water-soluble is carried in lipoproteins. And yes, your cells need triglycerides for energy. LDL also plays an important immunity role, along with helping repair damage in your body. The ketogenic diet is powerful. It reduces your body's requirement for insulin and can be a driver for what's called autophagy, which is when your cells recycle damaged parts into usable protein. And it may help slow down the aging of cells, along with reducing your risk for cardiovascular disease. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Twitter: https://twitter.com/DrBergDC Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

Welcome To The MedFlashGo Podcast. This Is Your Daily 4 Minutes Or Less Rapid Review for medical students. Topics are based on medical board examinations including USMLE, COMLEX, And Shelf Exams. We release a new episode every weekday! In this question of the day, Sean asks students to identify which lipoprotein matches the function in the question. These questions are powered by MedFlashGo The First Voice-based interactive medical question bank currently available on Alexa. This tool allows medical students to study medical topics and be interactively tested without the use of a screen. You can study on your couch, in your car, and on the move without the use of a screen. To get access to the free audio-interactive question bank, click here or go to your Alexa application and search medflashgo In the skills section. To learn more details go to medflashgo.com and check out our frequently asked questions section. Please know that these questions were creatively designed by medical students and physicians for the purpose of education and do not replace health information given from your health professionals. We have tried our best to make sure the information is accurate please, so please let us know if you find any errors and we will be sure to correct them. --- Send in a voice message: https://anchor.fm/medflashgo/message

Dr. Samia Mora is an Associate Professor of Medicine at Harvard Medical School, Boston, Massachusetts. She is a cardiovascular medicine specialist at the Brigham and Women’s Hospital, where she is the Director of the Center for Lipid Metabolomics. Dr. Mora’s research focuses on risk factors and prevention of cardiovascular disease. Dr. Mora received her undergraduate degree from Harvard University, and her medical degree from Harvard Medical School. She completed an internal medicine residency at Massachusetts General Hospital and a cardiovascular disease fellowship at The Johns Hopkins Hospital, where she also obtained a Masters in Health Science (Epidemiology) from the Johns Hopkins Bloomberg School of Public Health. This episode is sponsored by Legion Athletics. Get 20% off your order using the code SIGMA. All US order come with free shipping and all international orders have free shipping on orders over $99. All orders have a money-back guarentee. Check out the products at buylegion.com Sigma Statement: https://sigmanutrition.com/lipids

This episode is the second part in a two part series talking about biomarker testing. If you have not listened to part 1 then do dive in (link below.) In essence, I utilised a testing service called Forth With Life (baseline plus test) in order to measure a series of bio markers over the last year or so ( initial test Aug 2018, follow up test Oct 2019.) This episode directly covers Cholesterol, Triglycerides and Lipoproteins (chylomicrons, HDL, VLDL, LDL.) I looks past ‘good’ or ‘bad’ cholesterol lovely people and I hope you find it useful. Forth with Life are not paying me to say any of this or do any of the testing. I self funded everything and bought their baseline plus test kits, because I was interested in looking under ‘the hood.’ Follow Forth With Life and their sports performance testing service Forth Edge: https://www.forthwithlife.co.uk/ https://www.forthedge.co.uk/ Listen to ‘Bio Marker Testing With Forth With Life - Part 1’ https://soundcloud.com/user-188029167/bio-marker-testing-with-forth-with-life-part-1 Listen to Ep 26 of the Big Feed Up HQ podcast with Sarah Bolt CEO of Forth ‘ A Deep Dive Into How To Interpret Your Blood Results With Forth’ https://soundcloud.com/user-188029167/a-deep-dive-into-how-to-interpret-your-blood-results-with-forth Some of my scores: Bio Marker - Aug 18 score - Oct 19 score - (Levels) Active B12 - 105 -118 ( Low

Did you know that there are four vitamins that can only be absorbed by the body in the presence of fat? On this episode, Ashdin shares with us interesting facts about vitamins and encourages the intake of fats. He also shares three guiding principles to a healthy life. Also check out Ep. 32: A Salad A Day You can follow Ashdin Doctor on Instagram @ashdindoc Check out Ashdin's website- Awesome180 Youtube Channel- The Habit Coach - Awesome180 This episode is powered by Storytel: https://www.storytel.com/in/en/ Use the link storytel.com/ivm to get a 30 day free trial as opposed to a 14 day free trial. You can listen to this show and other awesome shows on the IVM Podcasts app on Android: https://ivm.today/android or iOS: https://ivm.today/ios, or any other podcast app. You can check out our website at http://www.ivmpodcasts.com/

Join us as we deep dive into the nuance of plaque progression with Nadir Ali. We get Nadir’s take on the endotoxemia hypothesis of plaque formation and atherogenesis, discuss the lipoprotein’s role in the body and immune system, and identify some key areas of focus for future research in holistic management of cardiovascular disease.

Carl and Carrie talk to Siobhan Huggins about how lipoproteins and the immune system work together

Today on the show, I discuss how inflammation contributes to the development of heart disease.  I also talk about why it is NOT the only factor and why despite what many low carb nutrition experts are claiming, lipoproteins still matter.  Tune in to find out more:   Linked Research:  Review of the role of oxidative stress and vascular inflammation in heart disease Inflammation and Lipoproteins and Their Relation to Heart Disease  Mechanisms of LDL Oxidation  

Laboratory testing is a key component of models of care for all types of lipid disorders.  New therapies demand accuracy of dyslipidemia testing at very low LDL cholesterol concentration ranges.  Inaccurate results lead to incorrect diagnosis and therapeutic management, both of which are costly to society and harmful to patients. To address these key issues of lipoprotein and apolipoprotein markers and reach consensus on contemporary lipid testing, a multidisciplinary panel was established by the European Federation of Clinical Chemistry and Laboratory Medicine and the European Atherosclerosis Society.       The July 2018 issue of Clinical Chemistry includes a special report from this joint consensus initiative.  It provides recommendations for improving the use of the lipid profile to assess cardiovascular disease risk conferred by atherogenic lipoproteins.  

We're back with the big 400! For this episode of the podcast we have guest Dave Feldman. Dave is a software engineer that began researching cholesterol and lipoproteins. If you want to learn some new info about cholesterol and lipoproteins, this is a super interesting one! Show Notes: 1:47 – Summary/Pre-Intro 3:19 – Dave Feldman Intro and background 4:45 – Cholesterol/Lipoproteins change and keto 10:30 – Dave’s experience with drastically changing lipoprotein number 12:00 – Role of lipoproteins and cardiac events 20:24 – No good reason to have high energy in the blood 23:50 – Engineering view of the human operating system 25:42 – Fat storage, and why lean people can have higher LDL cholesterol 28:46 – How to distinguish between lean person’s and overweight person’s lipoprotein patterns, and lean mass hyper-responders 33:02 – Dairy (saturated, monounsaturated, and polyunsaturated fat) and carbohydrate’s effects on lipoproteins 40:26 – Minnesota coronary experiment 41:50 – Don’t blame the mirror for how bad you look 44:25 – Dairy, hyperpalatability, and whole unrefined foods 46:12 – Dave recording cut out, send us questions for a part 2 followup with Dave Website: http://cholesterolcode.com/ Twitter: @DaveKeto Facebook: https://www.facebook.com/DaveFeldmanLC/

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Hey Folks! You asked for it, and we delivered. We're back with a Q&A episode! If you have a question for a future episode, submit them here https://robbwolf.com/contact/submit-a-question-for-the-podcast/   Show notes: 1. (4:41) Ketosis and Carbohydrate timing Ryan says: Hi Robb. I don't know if this will reach you, but while listening to your podcast and reading your first book, a hundred questions pop into my head. This is one of them. I thought about asking my doctor, but I knew a blank stare and a sweaty forehead would be his answer. So here goes: Does frequency of carb intake play a role in disrupting ketosis? For example, if I am going to eat 150 grams in total of carbohydrates today, will eating all 150 grams of carbs at the same meal knock me out of ketosis for an EQUAL amount of time as eating 15 grams every hour for 10 hours?* My theory is eating 15 grams of carbs an hour for 10 hours will be just enough to keep a person out of ketosis for a longer period of time than eating all 150 grams in one meal while carb-fasting for the rest of the day. I could be wrong, but that's why I'm asking the master. Thank you in advance for any time you can dedicate to the this question. Have a great day. *Lets assume we are talking about starchy carbohydrates (rice, potatoes, etc.), not leafy green vegetables or other low glycemic vegetables. ------------ Links: Meal frequency and timing in health and disease-PNAS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250148/   2. (9:34) Genetics and Keto Charles says: Robb mentioned in the Paleo(f)x keto interview that he had some genetics (SNPs) that perhaps made Keto not a great diet for him, yet he gets around it somewhat with some supplementation including with Carnitine. I dabble in Keto and have made lots of progress with my health as a result. I plan to sign up for the Master Class too. I have done genetic testing already with 23 and me. I wonder if Robb could tell me the SNPs to look for to see what kind of genetic fit Keto is for me. I have a feeling I will find out in the Master Class, but would love to hear what Robb has to say or perhaps there is a link to an article or podcast that would do the trick. ------------ Found my fitness genetic interpretation: https://www.foundmyfitness.com/genetics FTO gene is called fat mass and obesity-associated protein because it is the gene that is the major genetic risk factor for obesity. This particular genotype, rs17817449(G;T), is associated with a 1.3-fold increased obesity risk. Saturated fat may have a negative effect on blood glucose and insulin levels and increases type 2 diabetes risk in individuals with this genotype. All sat’d fats the same?? NO. No one asks why this is: Sat’d fats increase endotoxemia to some degree: Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia-Nutrition and metabolism https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-10-6 Sat’d fats also tend to increase Lipoproteins and cholesterol, at least in some people. Is that bad? Maybe, maybe not, #context: https://www.google.com/search?q=LPS+clearance+lipoproteins&oq=LPS+clearance+lipoproteins&aqs=chrome..69i57.6086j0j4&sourceid=chrome&ie=UTF-8 Multiple mechanisms: 1-LPS binding protein 2-Multiple hepatic cells and receptors, including LDL-receptor 3-Small, dense lipoproteins work better for this!! In total, this FTO mutation is overall beneficial in dealing with endotoxemia dn infection. Consistent with other SNP’s I have (celiac potential, mild iron accretion). Shows direct influence of adaptations to agriculture. DAIRY really increases this for me.   3. (16:51) Familial history of cancer and the Ketogenic diet for prevention Clint says: Hey Robb- When I look back into my family history, a boatload of people have had various forms of cancer. We've run the gamut of colon cancer, breast cancer, cervical cancer, etc... I've listened to quite a few podcasts with Dominic D'Agostino in regards to the ketogenic diet as a tool in the toolbox for combating cancer and lessening the effects of Chemo. I've also heard on various podcasts the use of periodic multi-day fasts to help expunge faulty cells from the body in hopes for cancer prevention. I've been looking into these methods of cancer prevention and wanted your two cents on the matter. I'm 32 years old, 6'2", 180lbs. I'm an endurance athlete/run coach and compete in races from 5k-100 miles. If, in your opinion, these are good tools in regards to helping keep cancer at bay, at what age should I start implementing them? How would I go about balancing a ketogenic diet and being an endurance athlete w/out completely frying my adrenals? I'm not necessarily against reassessing my performance goals to include goals of health and longevity. It's not like I'm being paid to be an upper-midpack runner. Thanks for all that you do! Really looking forward to the new book Clint aka "Run Coach Clint" ----------------------- Likely sweet spot for IF is 18-24hrs: https://medium.com/the-mission/the-sweet-spot-for-intermittent-fasting-9aae12a2158c Scant evidence of periodic starvation among hunter-gatherers. https://www.ncbi.nlm.nih.gov/pubmed/10096796   4. (24:25) Fasting impact on weight training Matt says: when doing longer fasts like 5-7 day should one stop weight training altogether or keep thing business as usual?   5. (26:32) Cycling the carbs: is it supposed to suck Kate the Great says: Hey guys, huge fan of the podcast, although I'm only a hundred-some episodes in and trying to catch up. Scroll down for the actual question. I eat Paleo (duh- how could anyone listen to 100+ hours of Robb Wolf and not eat that way), which means no grains, dairy, legumes, or sugar. I'm also well on my way to converting the metabolically-resistant trifecta of my Baby Boomer mother and father and my Hot Cheeto-loving fiancé-- which seems to be the Holy Grail of Paleo living. I actually "discovered" Paleo when my fiancé and I did a month-long no-sugar challenge. Part of the protocol involved eliminating grains and dairy before adding it back in, and I noticed how much better I felt when ate things besides grain, dairy, and sugar. Turns out there is a name for it. I shortly transitioned into low-carb Paleo, around 50g-65g/day, because I got healthier and felt better simply eating meat, fish, eggs, sardines, avocado and coconut, and low-starch vegetables. On low-carb Paleo, I started absolutely shredding weight and dropping body fat. 16% to 12% body fat in two weeks- which was very alarming. My body adapts pretty quickly to whatever is thrown at it, and I tend to gain muscle and drop fat easily, but this was definitely unprecedented. After seeing that weight loss, listening through the podcast, and choosing to add in a few more weekly sessions of BJJ and Muay Thai, I figured it would be prudent to add in some high-carb days. Here's the curve ball: I'm a cop who works the road, but with a balling swing-shift schedule. 4 days on/4 days off, 1:30 PM to 1:00 AM (and we get paid an hour a day to workout). From what I hear, shift work is the devil, but I haven't had any problems with it. Yet. I started adding in a high-carb (200g) day every 8 days- it falls on my first day off. Carbs come from corn chips or tortillas at a Mexican restaurant, homemade coconut flour pancakes with banana and blueberries, and tons of raw vegetables (like a party-tray of dipping veggies with no dip). Here's the problem: on high carb days, I feel like BUTT. Bloating, fatigue, rapid heart rate, inability to focus my eyes or even keep them open, crashing and sleeping 14 hours that night, confusion, extreme thirst, muscle cramping, headaches, stuffy nose, and mental fog. On the following day, I am sluggish to wake up, but fine by the afternoon, and absolutely slay workouts. I'm talking adding 20 lbs to previous weeks' lifts, or able to go for hours nonstop in the ring. I love what the high-carb days do for me, but I hate them in the moment. This crash doesn't seem normal or healthy, and I can't figure out what it's coming from. Is it (1) a possible gluten exposure/cross-contamination? (2) a downer after four days of high-adrenaline work? (3) entirely too much fiber? (4) a combination of all the above? And am I giving myself the diabetes? What is the reason for this crash; is it a necessary part of carb-cycling, and how do I make it stop? I would go back to all low-carb, but I want to stave off further weight loss and pre-empt a hormonal clusterf*ck with the high-intensity workouts, high-stress job, and low-carb. Trading Card Stats: +27 YO female +5'10" 150 lbs., 13% body fat (walked myself down from 200 lbs and 20% body fat as an SEC hammer thrower 5 years ago) +Literally perfect lab blood work +BJJ, Muay Thai, long walks on the beach and candlelight dinners during my four days off (no but really, lots of walking with the martial arts those days) +Olympic lifting and power lifting (working off Rusin's FHT program right now, but historically have designed my own) and running (sprints or middle distance no greater than 3 miles) on work days +roughly 150g protein, 100g fat, 50g carbs on low carb days; 150g protein, 20-30g fat, 200g carbs on high-carb days +supplement with Carlson's fish oil, Natural Calm most nights; adaptogenic herbs or tea PRN after a high-stress work day (get shot at or crash the car, etc.) +7 hours of sleep on work nights, 9 hours of sleep on off nights +Hormonal girl stuff is fine. Goals: +Health, longevity, mitigate a stressful job +Maintain excellent PT scores (1.5 mile run, 1-minute pushups, 1-minute sit-ups, 300 meter sprint) +SWAT tryouts in a year: involves a 24-hour physical endurance and shooting test with 80 lbs. of gear +Continue to improve in martial arts so I don't get my narrow Paleo butt handed to me on the street by some dude who eats 7-11 hot dogs. Huge thanks to you and the team. Don't get any ideas or anything, but I can't believe all this is free. Love and support from VA.   6. (31:20) Weight loss--How much is too much? Jacquelyn says: About a month ago, I began the sugar elimination Paleo Meal plan. I needed to lose a lot of weight. I have spinal stenosis, severe lumbar arthritis and in the right hip. high blood pressure, prediabetes, Hashimoto's disease, lactose and gluten intolerant, etc. I take medication for the high blood pressure and the Hashimoto's disease. I've been going to the gym for 18 months---working on various muscle groups and doing cardio. I lost NOTHING, but my muscles did firm up---so I lost inches. My doctor and physical therapist were both nagging me to change something to get the weight off. I met with a friend of mine who has a company called: Verri Well. She advised me to do the sugar elimination plan (meat, veggies and fruit each meal). and see how it goes. I did. Within 4 days, the chronic pain I had in my lumbar spine and right hip disappeared. I continued eating meals based on the plan and going to the gym or walking everyday. At the end of a month, I went to my doctor's office for a check in. I lost 35 lbs in the first month. My doctor freaked out saying that it was dangerous for my organs what I was doing. I needed to slow down the weight loss and put peanut butter, bananas back in my diet and lose the citrus fruits. Well, I'm not going to do that because I feel it would hinder my progress. I like the way I'm feeling. My doctor added that my heart and kidneys would not be able to take the rapid weight loss. So, I am asking you for a general opinion. If I am working out everyday, and sticking to a paleo meal plan---Is a weight loss of 35 lbs for the first month unheard of or dangerous for my organs (starting weight was 280lbs)??? If so, what should the amount of pounds be for weight loss? Or does it even matter? I can see my doctor's position if I was anorexic or bulimic. But that is not the case at all. Thank you for reading. I really need your help with this.   Twitter: @RobbWolf Instagram: @dasRobbWolf Facebook: @RobbWolfOnline

Commentary by Dr. Valentin Fuster

In this episode, I discussed cholesterol, apolipoproteins (ApoA1, B48, B100, CII, and E), and lipoprotein particles (chylomicrons, VLDL, IDL, and LDL). Enjoy!The Med School Phys podcast discusses topics in human physiology. Our primary aim is to help medical students learn/review high yield material for their classes and board exams. Hopefully listeners find that this alternative audio-based learning format works for them. This podcast is intended to be educational and all the information shared herein is publicly available through the internet. Med School Phys is an independent project and currently shares no affiliation with other organizations, companies, or academic institutions.-You can email me questions or constructive feedback at medschoolphys@gmail.com -Check out my book, Read This Before Medical School: https://www.amazon.com/dp/B07YCXZM3X/ref=docs-os-doi_0 -Episode transcriptions can be found at: https://drive.google.com/drive/folders/12QQSFho-ThIIeZuulsblGSnnNL8oJ7ag?usp=sharingDISCLAIMER: All information, content, and materials published by the Med School Phys podcast are for informational purposes only and are NOT intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified healthcare provider. Please consult your healthcare provider regarding personal medical decisions.

In this episode, I discussed cholesterol, apolipoproteins (ApoA1, B48, B100, CII, and E), and lipoprotein particles (chylomicrons, VLDL, IDL, and LDL). Enjoy!The Med School Phys podcast discusses topics in human physiology. Our primary aim is to help medical students learn/review high yield material for their classes and board exams. Hopefully listeners find that this alternative audio-based learning format works for them. This podcast is intended to be educational and all the information shared herein is publicly available through the internet. Med School Phys is an independent project and currently shares no affiliation with other organizations, companies, or academic institutions.You can email me questions or constructive feedback at medschoolphys@gmail.comYou can share a link to our episodes via Spreaker or encourage others to listen on their podcasting app of choice: https://www.spreaker.com/user/medschoolphysFind our Youtube channel at: https://www.youtube.com/channel/UCXEEgC1JZysYsKy9NRYisEQEpisode transcriptions can be found at: https://drive.google.com/drive/folders/12QQSFho-ThIIeZuulsblGSnnNL8oJ7ag?usp=sharingDISCLAIMER: All information, content, and materials published by the Med School Phys podcast are for informational purposes only and are NOT intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified healthcare provider. Please consult your healthcare provider regarding personal medical decisions.

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

Dana Laake and her special guest Jan M. Troup, Ph.D., will be discussing LPP, an advanced lipoprotein test for better cardiovascular risk assessment. Jan M. Troup has over 30 years experience in the development of new analytical technology. He earned his Ph.D. in chemistry from Texas A&M University in 1974. In 2001 Dr. Troup started LipidLabs, Inc. and developed the Lipoprotein Particle Profile (LPP), the most advanced test for the separation of lipoproteins and measurement of lipoprotein particle numbers. LipidLabs was purchased by SpectraCell Laboratories in January 2006 and Dr. Troup is now the Director of Lipid Science at SpectraCell Laboratories.

Mon, 1 Apr 2013 12:00:00 +0100 https://epub.ub.uni-muenchen.de/23946/1/oa_23946.pdf Weber, Christian; Winkels, Holger; Gerdes, Norbert

In this week's episode of Escape from Caloriegate, we welcome Alan Watson of DietHeartNews.com. Alan is an accomplished author and nutrition researcher, whose works include "21 Days to a Healthy Heart" (2002) and "Cereal Killer: The Unintended Consequences of the Low Fat Diet" (2008). I believe his "Illustrated History of Heart Disease 1825-2015" piece is a MUST READ. Please check it out and share it around. Watson is a convincing advocate for a low carb, high fat, whole foods diet, and he spoke at length about the fascinating relationship between diet and heart disease. Here are some cool highlights from the show: In the last 50 years, we have seen a HUGE shift in the American diet. In 1910, lard was the #1 cooking fat. At Watson's grandfather's dairy farm, skim milk was fed to pigs to fatten them; cream was hauled off to make butter. Mortality from heart disease was just 3-8%, Today, it's 45%! Our genes don't change that fast. What HAS changed is the quality of the food we're eating. Since 1960, sugar consumption has spiked 40%, as has grain consumption. Butter consumption, meanwhile, went down by 30%, and we eat 18% fewer eggs. We've shifted away from natural fats to soybean oil and processed fats. Since 1980, obesity / diabetes has surged, and heart failure has doubled since 1987. The type of fat we're eating has changed dramatically. We're consuming much more polyunsaturated fats -- too much damaged omega 6, which leads to inflammation. Scientists now believe that inflammaton is the cause of heart diease... and not cholesterol. Yet the 2010 Dietary Guidelines lump saturated fats with trans fats, calling them "solid fats," which doesn't mean a thing. Dr. Mary Enig, in her book "Know Your Fats," provides compelling evidence that, inside the body, saturated fat and trans fat behave completely differently. Beef fat = predominantly oleic acid, the same "healthy" monounsaturated fat found in olive oil. Used to be: skim mlk was given to pigs to fatten them up. Today, we give skim milk to our kids. Compare two breakfast: Alan eats three eggs fried in lard with sausage. I eat a bowl of cheerios with skim milk and a glass of O.J. Whose breakfast is more "heart healthy"? I'm meeting Dietary Guildlines; he's off the charts in the "wrong direction." Dietary fat and cholesterol end up in the intestinal wall: the body breaks down fats, then reassembles them into triglycerides, which are put on chylomicrons (apoB48) and delivered to the body's 70 trillion cells. These chylomicrons have a half life of just 14 minutes; within that time, body snatches up all that fat -- that's how important fat is! Within just 2-3 hrs after the meal, very little signs of apoB48. It's gone, into the cell membranes, etc. My meal is another story! The skim milk contains sugar (galactose) and very little fat. All the sugar goes into the blood. Fructose goes to the liver. My meal will take the liver 12 hours to process. The liver then sends that out in VLDL, which loses its fat and becomes LDL, which delivers cholesterol to the body. Dietary fat has nothing to do with LDL! LDL is related to carb intake. Dietary fat is innocent: a completely different pathway. When people get bloodwork done, they should ask for VLDL count. LDL # doesn't really mean much or predict much, b/c it's not the amount of LDL in the circulation that matters; it's how many particles there are. Lipoproteins are particles -- we can count them. Counting VLDLs gives us a reliable predictor of heart disease: triglyceride count and size of LDL particles. AHA did a 6 year study of hospital admissions in 542 hospitals. Did lipid profiles on people -- checked HDL and LDL. Study went over 5 years. 75% of people who had heart attacks had LDL below 130. 50% had LDL below 100! Astonishingly, researcher's conclusion was "maybe we have to lower LDL even more." We've always been told that LDL is bad and HDL is good b/c HDL offers reverse ...

Interview with Margaret D. Carroll, MSPH, author of Trends in Lipids and Lipoproteins in US Adults, 1988-2010

Collectivistic statist turf war insanity King rejects govt's resignation, for now by Robert Wielaard http://www.washingtontimes.com/news/2008/jul/17/king-rejects-govts-resignation-for-now-1/ Governmental "officials" tear markets apart and extol self-sacrifical "public service" D.C. Arrests Residents For Missing Jury Service by Keith L. Alexander http://www.washingtonpost.com/wp-dyn/content/article/2008/07/13/AR2008071301798_pf.html Forced "justice" makes perfect sense, doesn't it; coercion is "cooperation" Jurors are essentially slaves of judges; jury nullification is illegal, sayeth "the law" The legal system benefits government and lawyers and screws the enslaved "customers" Once again, voting and jury nullification are not needed to achieve liberty; rather, people's independent mindset is Legislature approves bill banning trans fats by Samantha Sondag http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2008/07/15/MN0111OTUA.DTL The 'land of ban' scoffs at the nature of property rights; public pressure is voluntary; governmental pressure is coercive The most important thing in the world that needs protecting: Your right to choose a couple interesting scientific articles related to cardiovascular health: Lipoproteins and Atherosclerosis -- The Role of HDL Cholesterol, Lp(a), and LDL Particle Size (just google the article title and click from there, if you get the annoying sign-in page) http://www.medscape.com/viewarticle/439375 Measurement of LDL and HDL particle size does not improve CAD diagnosis http://www.lipidsonline.org/news/print.cfm?aid=6602 Genetic-testing start-ups asked to stop selling in Calif. by Stefanie Olsen http://news.cnet.com/8301-10784_3-9971383-7.html?hhTest=1 Perfect example of the regulatory State; following the money trail and areas of corporate convolution What a free market in medicine would be like: everything becomes more and more affordable Bush lifts executive ban on offshore oil drilling http://www.cnn.com/2008/POLITICS/07/14/bush.offshore/index.html Politics in midstream, once again, based on central planning; rather, all drilling areas should be privately owned and regulated--and thus be accountable here's a great blog post with lots of info: The Oil Pricing Squeeze Is On by David Theroux http://www.independent.org/blog/?p=140 Deadliest job in America: Working on cell phone towers http://tech.yahoo.com/blogs/null/97827 OSHA fascists to the rescue! Give me a break; say goodbye to common sense and productivity; workers know their work best; rational tort law All the most vile forms of tyranny come from the edict that "This is for your safety"--as if we should look to a coercive monopoly to protect us The guiding light for people in the free market: Use your own judgment, do things reasonable and prudent based on the circumstances, and don't follow authoritarian rules for their own sake Loss of personal control and belief in Higher Powers http://atheists.meetup.com/518/boards/view/viewthread?thread=5064714 Need for self-esteem and individual choice "But Who Will Build the Roads" Market Anarchy Explained http://www.newhampshirefreepress.com/NHFreePress/?q=node/166 The contradiction of government: Evil people controlling other purportedly evil people? Death By Government by R. Rummel http://tinyurl.com/rusyx The governmental employee modus operandi: passing the buck and shirking moral responsibility They Didn’t Attack Switzerland by Bill Walker http://www.lewrockwell.com/walker/walker32.html The whole "war on terror" is ill-gotten; US government only protects their own (and even that fails) Collectivistic thinking treats States as quasi-individuals; coercive government is the real problem, not a State that has an interventionist foreign policy bumper music "All You Fascists" by Billy Bragg And Wilcohttp://www.billybragg.co.uk/releases/albums/mermaid_avenueII/merII11.html to comment, please go to http://completeliberty.com/magazine/category/91697  

In patients after elective abdominal surgery, different fat emulsions were used to compare their efficacy in total parenteral nutrition and in normalizing plasma lipoprotein levels. In five different groups with 5 patients each, half of the nonprotein calories were given as medium-chain triglycerides/ long-chain triglycerides (1:1) or as long-chain triglycerides alone in 10 or 20% fat emulsions or as glucose alone in a control group for 7 days. After surgery, an initial decrease of all plasma lipoprotein components was followed by a different behavior of glyceride-glycerol, cholesterol, phospholipids, and apolipoproteins. Glyceride-glycerol in very-low-density lipoproteins and high-density lipoproteins is increasing during infusion of fat emulsions and decreasing during overnight interruption of infusions. After the 7-day infusion period, there was no significant difference in very-low-density lipoprotein glyceride-glycerol as compared with the values before different infusions, Low-density lipoprotein cholesterol is reaching and exceeding preoperative concentrations between the 4th and the 7th day, most during infusion of 10% fat emulsion and especially due to an increase of free cholesterol, High-density lipoprotein cholesterol and apolipoprotein A-I reach preoperative levels during infusion of fat emulsions but not with glucose alone, Higher than preoperative values are reached in phospholipids with all fat infusions already on day 4, Abnormal lipoprotein X occurred least with the medium-chain/long-chain triglyceride 20% fat-infusion. This fat emulsion is suggested as having the best normalizing effect on plasma lipoproteins and best tolerance in patients after surgery.

The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis. To prove this hypothesis, we compared serum lipoprotein profiles with the excretion of high density lipoproteins in urine in 19 nephrotic patients. Serum cholesterol ranged from 19–152 (median value 45) mg/dl in very low density lipoproteins (VLDL), from 130–443 (median 186) mg/dl in low density lipoproteins (LDL) and from 19–64 (median 33) mg/dl in high density lipoproteins (HDL). Hyperlipoproteinemia was found in 17 patients, which was classified as phenotype IIa (Fredrickson) in 2, as phenotype IIb in 9 and as phenotype IV in 6 subjects. Two patients showed normal lipoprotein patterns. VLDL- and LDL-cholesterol were not found in detectable amounts in urine, whereas HDL-cholesterol was measured in low concentrations from 0.1–8.3 mg/24 h in all samples. There was no correlation between serum HDL-cholesterol and urinary HDL-cholesterol, but a positive correlation between serum LDL-cholesterol and urinary HDL-cholesterol (r= +0.54, p < 0.05). However, the total amount of the daily urinary loss of HDL (