Podcasts about isomer

In this episode of the EUVC podcast, our host, David Cruz e Silva, talks with Chris Wade, Co-Founder of Isomer Capital, to explore the evolving European venture landscape in 2025. Reflecting on a decade since Isomer's inception, Chris shares insights on the industry's growth and how Europe has expanded from just 20 unicorns in 2014 to nearly 400 today.Here's what's covered:02:25 Celebrating 10 Years of Isomer05:39 The Growth and Future of European Venture Capital08:43 Challenges and Opportunities in the VC Landscape17:56 Transparency and Communication in Venture Capital25:57 The Role of VCs on Company Boards27:17 Understanding DPI and Secondary Transactions39:16 The Future of European VC and Emerging Managers

In this episode of the EUVC podcast, David discusses with Chris Wade, Founding Partner at Isomer Capital.David and Chris discuss the current sentiment in the European venture capital ecosystem. They touch on topics such as VC sentiment, comparisons to previous years, LP appetite, the potential IPOs of Revolut and Klarna, the rise of AI and semiconductor companies, and the geopolitical and economic uncertainties affecting the industry.Chris also reflects on the positive and negative developments in 2024 and the importance of humanity prevailing over negative forces.Go to eu.vc for our core learnings and the full video interview

In this work, we introduce Unique3D, a novel image-to-3D framework for efficiently generating high-quality 3D meshes from single-view images, featuring state-of-the-art generation fidelity and strong generalizability. Previous methods based on Score Distillation Sampling (SDS) can produce diversified 3D results by distilling 3D knowledge from large 2D diffusion models, but they usually suffer from long per-case optimization time with inconsistent issues. Recent works address the problem and generate better 3D results either by finetuning a multi-view diffusion model or training a fast feed-forward model. However, they still lack intricate textures and complex geometries due to inconsistency and limited generated resolution. To simultaneously achieve high fidelity, consistency, and efficiency in single image-to-3D, we propose a novel framework Unique3D that includes a multi-view diffusion model with a corresponding normal diffusion model to generate multi-view images with their normal maps, a multi-level upscale process to progressively improve the resolution of generated orthographic multi-views, as well as an instant and consistent mesh reconstruction algorithm called ISOMER, which fully integrates the color and geometric priors into mesh results. Extensive experiments demonstrate that our Unique3D significantly outperforms other image-to-3D baselines in terms of geometric and textural details. 2024: Kailu Wu, Fangfu Liu, Zhihan Cai, Runjie Yan, Hanyang Wang, Yating Hu, Yueqi Duan, Kaisheng Ma https://arxiv.org/pdf/2405.20343

Celebrating one of the finalists in the Firm of The Year-category at this year's European VC Awards, this episodes dives deep with Stephen Chandler, Co-founder & Managing Partner of Notion Capital. With 1.1 bn€ under management and 5 flagship funds under their belt, Notion is one of Europe's absolute top firms and in this episode, Stephen dives into a level of detail rarely seen discussing everything from the guiding principles building Notion to the process and learnings from raising their latest fund. I highly encourage you to read Stephen's notes below and tune in for this episode. I truly think this is one of our best to date. Notion at glimpse:Fund Name: Notion CapitalFund size: €300m (Fund V)AUM: €1.1bnHQ Country: UKTarget Stage: Series A focus, but invest across pre-seed to growthTarget Geography: Pan EuropeanTarget Sector/Vertical: Business Software & FintechNotable Investments: CurrencyCloud, Easol, GoCardless, Mews Systems, Paddle, Upvest, YulifeFrom the principles building Notion to the learnings from raising fund V oversubscribed and the decision to clone his dog, this episode is one of our best to date. Don't miss Stephen's notes on eu.vc - they're legendary.Big shout out to our Firm of The Year Sponsor Haynes Boone.And you don't have to take it from themselves, take it from one of their long term clients, Joe Schorge: "Having worked together for many years now, they fully understand the Isomer ethos and process, and we really appreciate the value that this long-term relationship brought to this mandate from start to finish. We look forward to continuing to work with Karma, Ronan, Will and the rest of team.”  Naturally, we're incredibly excited about having the Haynes Boone team with us as sponsors of the Firm of The Year Awards - yet another testament to their support for the EUVC ecosystem. We strongly encourage you get in touch with Karma and the team for a great experience

The landscape of venture capital is evolving, and Isomer Capital is at the forefront with its new fund designed to meet the dynamic needs of the European venture capital market.We sat down with Joe Schorge and Omolade Adebisi from Isomer to talk through the market, the strategy and the future. Well-worth a watch as we open up the deck that raised the fund and tap the brains that incept and run it. But let's get the headline numbers in place:100 M€ Fund dedicated to secondaries exclusively.65-75% of dedicated to acquiring Limited Partner (LP) interests in existing VC funds.An additional 15-25% is earmarked for direct secondaries in companies, providing crucial liquidity to stakeholders.The remaining funds, up to 15%, are reserved for discretionary investments, which may include buying stakes or carry from general partners.This strategic distribution of funds is a response to the current market conditions where many European VCs have yet to realize significant returns from their investments. These circumstances often necessitate liquidity solutions for personal reasons—such as purchasing homes or funding private education—or professional requirements like meeting General Partner (GP) commitments for raising new funds.Typical ticket sizes range from €1 million to €10 million injecting much-needed flexibility and liquidity across Europe's venture capital ecosystem and broadening Isomer's impact beyond the traditional fund of funds model to include any Europe-based fund or startup

Join us as we step back and chart the evolution of European VC with a true O.G. Roundtable:Yaron Valler, Founding Partner at Target GlobalChris Wade, Founding Partner at Isomer CapitalKerry Baldwin, Founding Partner at IQ CapitalAnd moderated by Andreas Munk Holm from EUVC and Gabriel Shin, CFA from Vauban from Carta

965 joined us for yesterday's roundtable on acing LP relationships - in case you missed it, listen here or rewatch on eu.vc

As we welcome 2024, let's reflect on the critical developments in scientific research and innovation shaped by geopolitical dynamics over the past year. This pod (and article on eu.vc) delve into the shifting landscape of international collaboration, emphasizing the roles of major global players and innovative breakthroughs in energy, space technologies, and generative AI.We'll explore how these advancements are influencing our sustainable future and expanding our cosmic understanding. Additionally, we examine the burgeoning world of AI, where rapid growth brings both opportunities and challenges in regulation and industry adaptation.A special focus is given to the evolving dynamics of startup ownership and control, illustrated by Open AI's public board deliberations.This case study highlights the complex balance of power among founders, teams, investors, and boards in guiding the future of pioneering companies.As we step into the new year, let's navigate these changes with insight and integrity, both professionally and personally. Here's to a year of positive impact and innovation. We hope you enjoy and have a great New Year's!

Welcome to the first episode of the special series NEUVC, hosted by Freddie Macpherson, analyst at Isomer Capital, and Linda Võeras, associate at Karma Ventures. Today we have Martin Krag with us. Martin is a partner at byFounders, a seed fund looking to back the best tech founders in the new Nordics. We spoke to Martin to hear how he rose to partner in four years, the firm culture and coaching the courage to do so, and, of course, his own secret sauce of excellence.Chapters:00:00:00 - Introduction of Martin & byFounders 00:01:52 - Incentive alignment and portfolio assistance00:03:24 - Joining a Startup Venture Capital Firm00:04:44 - The importance of decisiveness for VCs00:06:07 - Using Analysts for Understanding Spaces and Sectors00:07:43 - Progression and Responsibility Levels00:09:17 - The Importance of Curiosity and Quick Learning00:10:41 - Finding Focus and Prioritizing00:12:09 - Balancing Networking and Board Responsibilities00:13:35 - The Fluid Partnership with Founders and Career Development00:15:09 - Building a Strong Team and Defined Roles00:16:42 - Calibrating New Hires for Long-Term Aspirations00:18:04 - Transparency and Core Values in VC Industry00:19:39 - Career Progression and Future at the Fund00:21:18 - The Responsibility of Partners and Youngsters in Investment Decisions00:22:40 - Avoidable Mistakes made by Junior VC Team00:24:29 - Being Patient and Calibrating Before Making Decisions00:25:58 - The Perspective of a Poker Player-Investor00:27:30 - Dreaming with the Founders00:28:57 - Diversifying Experience in the VC Industry00:30:42 - Choosing between being a VC or Founder00:32:19 - The Challenges of Being a VC00:34:14 - Building a Fund and Firm00:36:15 - Experience and Bad Judgment

Today we present Freddie, analyst at Isomer, the venture fund of funds backing Europe's VC champions early and doubling down on their breakout companies, and Linda, associate at Karma Ventures, which is a deep tech VC in Estonia, focusing on Series A companies in the Baltics.We want to welcome you to the NEUVC podcast series, a limited edition series dedicated to those entering and on their journey in VC, sharing the insights, stories, and learnings from different voices in the industry. There are many ways into VC and a number of skills that can make you successful in this industry. Upon closer inspection, many investors possess superpowers that are super useful for finding new deals, helping portfolio companies grow and succeed, as well as getting the deal signed and sealed.The series is dedicated to exploring those unique superpowers in some of the trailblazing venture ladder climbers in Europe, drawing out learnings about how to develop them, use them and leverage them. So to this effect, we spoke to a wide range of voices, managing partners, recruiters, principals, and even marketing specialists, to provide a diverse range of opinions on how to help you improve at your job. Hope you'll enjoy!

Welcome back to the Alt Goes Mainstream podcast.Today, we travel to London to talk with someone who has seen the evolution of the European tech ecosystem up close.We discuss the rise of Europe with Isomer Capital's Co-Founder and Managing Partner Joe Schorge. Isomer is a pan-European fund-of-funds, co-investment, and secondaries platform that is on its way to €1B AUM. They've invested in 70 VC funds, including the likes of Seedcamp, Hoxton Ventures, Atlantic Labs, and leading European companies like Sorare, Refurbed, Zenjob, and more.Joe has a fascinating perspective on European's tech ecosystem on a number of dimensions. He's an American who moved to Europe in the late 1990s to work in tech before moving to the allocator and investor side. He worked as an investment consultant at Cambridge Associates, where he advised institutional investors in Europe and MENA on strategy, planning, and implementation that amounted to over $2B of capital across 75 transactions in private markets. He was then a Managing Director at Pomona Capital in Europe, where he focused on secondaries, fund investing, and co-investments, which paved the way for him to found Isomer as one of the early institutional pan-European fund-of-funds based in Europe.Joe and I had a rich conversation about the past, present, and future of the European tech ecosystem. We discussed: Why Europe is a great place to invest right now. Perspectives on how to build a tech ecosystem, given Joe's deep experience and history in Europe. How they uncovered two local funds which invested in one of Europe's biggest tech successes, UiPath. The biggest opportunities in the ecosystem. Why availability of capital is not the issue for the European ecosystem. Why local funds will still win in their respective regions at pre-seed and seed. Why there are different skillsets that both investors and founders need to have to succeed in Europe. What the current market environment means for European venture. Why more institutional investors should be allocating to European venture. Thanks Joe for coming on the Alt Goes Mainstream podcast to share your wisdom and experiences about European venture and thanks to the EUVC team, Andreas Munk Holm and David Cruz e Silva, for the intro to Joe, where they together have a fantastic partnership between Isomer and EUVC.

Welcome to today's roundtable on raising in a bear market. We have some of Europe's best and most active LPs with us to discuss the following three topics: LP views on the state of the current market and when you see the light at the end of the tunnel?The most important considerations the panel sees managers having today and the tactics they employ to be successfulAdvice from the panel to managers thinking about embarking on the raise of their first fund today.Speakers:David Dana - Head of VC Investments at EIFJoe Schorge - Founding Partner of Isomer CapitalChristian Roehle - Head of Investment Management at KFW CapitalMichael Sidgmore - Co-Founder & Partner at Broadhaven Ventures by Broadhaven Capital PartnersAnd finally, we just wanna give a massive shoutout the sponsor of this roundtable: Affinity without whose continued support we couldn't dedicate all our time to create content like this roundtable for you. So if you're not yet a client, our message is clear: do reach out, say thx and consider if they're the platform for you!

Today is a special one as we have three guests with us, Joe Schorge and Chloe Dagnell from Isomer Capital (Europe's hands-down best Fund of Fund — full disclaimer, we're VP at Isomer! lol) and Benjamin Notlev, COO and CIO at TechBBQ, the leading tech conference in the Nordics - and also (announcement alert!), EUVC's Country Ambassador in Denmark

Today, we're happy to welcome Sara Rywe, partner at byFounders, a Nordic and Baltic's early stage tech investor with a difference.They stand toe to toe with founders and have a community driven approach to investing. Founders know exactly what they're getting into when they engage with byFounders from the metrics they're looking for to ticket size, investment terms, and the fund standard term sheet. It's all published on their website.Portfolio founders also have access to the wisdom of the byFounders collective, a group of experienced founders, tech experts, and more who can help them through the company building journey. The firm has two funds under its belt and invests across tech sectors. Sara joined in 2019 as an associate with a focus on finding funding and having the back of founders across the new Nordics.But for someone who's had a meteoric rise through VC, Sara describes herself as someone completely ordinary. In many ways, Sara's prior experience at McKinsey, her MBA and the fact she's a Kauffman Fellow gloss over the fact she did not originally pursue a conventional path. She'll talk more about her journey starting work in her teen years at McDonald's through to her entrepreneurial journey, starting up a dance school, and how this led her to catch the founder bug and lead to opportunities in tech.Sara's deep interest is in impact aware startups. She's mentored and invested in startups in sectors that combine profit with purpose and has a particular focus not just on responsible companies, but responsible founders. In this episode, we'll hear more about Sara's journey into VC, her path to partner, and how she's turned her interest and impact into a core pillar of the investment strategy and decision making process at byFounders.

Welcome to At The Cap Table podcast, a new series that shines the spotlight on the investors who are changing the vc industry in Europe. Today your host Savs Tan welcomes Deepali Nangia, Partner at Speedinvest. Speedinvest is a hands-on, pan-European early stage tech investor, partnering with founders from their early stages and helping them to grow game changing businesses. The Speedinvest team is one of the most active investors in Europe and last year announced 500m€ of fresh capital to invest in new ventures, and to continue to back their existing portfolio. The firm manages more than €1 billion in AuM and although it started in Austria, counts a team of over 40 investors based in Berlin, London, Munich, and Paris.Deepali joined Speedinvest as a Partner with a focus on finding, funding, and supporting investment in underrepresented founders but the majority of her time in venture capital has been as an angel investor, supporting startups from day 1.In this episode you'll learn:– About how Deepali's thesis in investing in female founders came through her own experiences of being underestimated in the workplace – How cleaning up the cap table is a myth: angels can continue to add value beyond capital and are a vital support for founders in a way that VCs cannot be, particularly in the early stages– Demystifying investment for operators could create a better angel ecosystem and is just as important as access to deal flow– Deepali's move from independent Angel to Partner at Speedinvest was not planned - she got to know the team and look at deals together before they developed a Venture Partner role for her, and she gradually became more and more involved with the firm before joining full time

Today we are happy to have Tobias Schirmer with us, Founding Partner of Join Capital, a 150m€ early stage venture capital investor in European technology startups providing access to industrial companies.Join Capital has an established portfolio of 20 companies and notable investments including Flexciton, Valispace, Opteran Technologies, Digital Spine, Frenetic.Joining Tobias as a guest on this episode we have someone who'll need little introduction to all of you: Joe Schorge, founding and managing partner of Isomer Capital, one of Europe's absolute strongest Fund of Funds.

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Earlier-than-expected first close of Isomer Capital's third flagship fund continues proven strategy of investing in Europe's best venture capital funds and their breakout companiesThe TL:DRIsomer Capital's track record and reputation as a ‘partnership' investor has enabled the firm's third flagship fund to reach a substantial first close ahead of schedule, despite headwinds in the macro-environment.Since inception, Isomer Capital has invested in more than 70 early-stage venture capital (VC) firms across Europe, gaining exposure to 29 unicorns to date, including the likes of UiPath in Romania, Tractable, Deliveroo, Oyster in the UK, ManoMano, Sorare in France, Wefox in Germany, and Dune Analytics in Norway.Isomer's proven hybrid fund of funds strategy is one of the best ways for institutional investors to access the high potential of European technology venture capital, by supporting European entrepreneurs creating the technology products of tomorrow. As a testament to this, IC II saw its net asset value (NAV) continue to increase in Q4 2022 against macro headwinds, maintaining its ranking in the top 5% of its kind globally.Isomer Capital has attracted investment from British Business Investments, the European Commission, and a range of endowments, pensions, corporates, and family offices from across Europe, Asia, and the United States.

Welcome to "At The Cap Table," the exciting new podcast series brought to you by your hosts, Sarah Finegan from Antler, Savitri Tan and Chloe Dagnell from Isomer Capital. Coming to you from London to showcase the top European female investors who are making waves in the VC industry.In this episode, we want to give you a glimpse into what this podcast is all about, who it's for, and why it stands out from the rest.As the European VC fund ecosystem evolves and diversifies, 'At The Cap Table' is dedicated to amplifying the voices of top female investors who are driving the VC industry forward.Each episode will feature a different leader who will share their insights, experiences, and strategies for backing the next generation of unicorn founders across Europe. We aim to cover a wide range of VC profiles, including partners at established funds, emerging managers, angels-turned-VCs, operators, and family offices.Expect fascinating stories from Balderton's Rana Yared about her invaluable experiences taking companies from seed through to successful exit, hear from industry experts like Deepali Nangia, who will share what it's like to make a move from angel investing into VC. And Check Warner who will discuss building a global movement to address barriers to entry in the industry, amongst many others.This podcast will bring you perspectives from investors all across Europe and beyond. We'll hear from investors in the UK, Germany, France, and more!This podcast series is proudly supported by our respective VC funds; Antler and Isomer Capital and brought to you by EUVC.Antler is the world's leading day zero investor and the most active early-stage VC firm in Europe, making 102 investments into European startups in 2022. We are committed to further increasing our investment rate this year to support the emerging world-class founder talent in Europe.Isomer Capital, on the other hand, is an LP supporting entrepreneurs throughout Europe through VC fund commitments, co-investments, and providing liquidity via secondary purchases of funds and companies. We've backed over 70 funds across Europe, and counting!Whether you are an investor seeking to learn from top investors across Europe or a founder looking to raise capital, this podcast is a must-listen for all early-stage investing enthusiasts.So, let's dive into the exciting world of venture capital and uncover the stories behind the success of Europe's most influential investors.Let's go!

Today we are happy to welcome Chris and Alexis.Chris Wade is an all-time favorite guest here at the EUVC Podcast, the co-founder of Isomer Capital is undeniably one of Europe's true OG LPs. With an extensive career as a founder, startup mentor and LP with more than 50 Venture fund investments under his belt, Chris co-leads Isomer's fund investments and leads their co-investment program.And we brought along for this episode Alexis Houssou, the Founder & Managing Partner of HCVC, an community-first early-stage venture capital firm that helps hardtech founders tackle problems with capital, resources and collaboration.In this episode, you'll learn: - The origin story of the relationship between Isomer and HCVC- Reflections from both sides of the table on managing LP relations in co-investments- Why Alexis thinks it's paramount that you only do co-investments with LPs/GPs when there's a lot of trust on both sides.- Why Chris thinks the overwhelming most important thing an LP can ask of a GP is to be transparent and trustworthy.- Reflections on the inconvenient yet fundamental truth: Funds don't make money, companies make money.

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Today we are happy to welcome one of Europe's true OG LPs: Chris Wade, co-founding Partner of Isomer Capital. With an extensive career as a founder, startup mentor and LP with more than 50 Venture fund investments under his belt, Chris is a guy you should want to know. At Isomer, Chris co-leads their fund investments and leads their co-investment program - and has a weekly section in the EUVC newsletter where he shares his perspectives and learnings from the week gone by. Tune in for the second of a two-part episode where we reflect on the year that has gone by and predict what is in stock for 2023.In this episode you'll learn:– Why Chris believes 2022 was a year of landmark achievements in technology that we should all remember and why perseverance and necessity are key to innovation– Why 2022 was also a year of tears, how Chris thinks about the war in Ukraine and it's impact on society and venture capital– What gives Chris hope going into the year of 2023

Today we are happy to welcome one of Europe's true OG LPs: Chris Wade, co-founding Partner of Isomer Capital. With an extensive career as a founder, startup mentor and LP with more than 50 Venture fund investments under his belt, Chris is a guy you should want to know. At Isomer, Chris co-leads their fund investments and leads their co-investment program - and has a weekly section in the EUVC newsletter where he shares his perspectives and learnings from the week gone by.Tune in for the first of a two-part episode where we, in this instalment, explore .In this episode, you will learn: How Chris' path as an entrepreneur has formed his thinking and behavior as a limited partnerWhy Chris chose to devote his life to found and build Isomer CapitalWhat guides Chris as an LP and how it informs you in your work with LPsWhy venture capital is like the road to enlightenment for a buddhist monk

For today's special series episode on navigating the current market with Europe's absolute VC elites we're talking to Chris Wade, Founding Partner of Isomer Capital - The O.G. of European LP investing. With investments in more than 50 European early stage VC funds counting anything from first time managers to the known greats like Seedcamp, Semantic, Hoxton, and Kindred, we thought Chris would be the perfect guest to dive deep on the effects on the current market on VC fundraising. On a final note, we should say that this episode is an edited version of a virtual event earlier hosted on LinkedIn, so in case you missed it; enjoy! and in case you're part of the 5.000 VCs that have seen it thus far; we hope it'll be worth revisiting.

How are isomers like ice cream? Originally published September 6, 2017.

Researchers at Chalmers University in Sweden have developed an entirely new way of capturing and storing energy from sunlight.  The system is called the Molecular Thermal Energy Storage System or MOST.  It is based on a specially designed molecule that changes shape when it is exposed to sunshine. The molecule is composed of carbon, hydrogen, […]

Breaking news: First time Isomer Capital talks openly about their emerging manager cornerstone program. For our in-person interview with Joe Schorge, founding and managing partner of Isomer Capital, at TEDxAthens, Joe Schorge revealed yet undisclosed details about their cornerstone program for emerging managers. In this episode you'll learn: - How Joe thinks about being an optimist in the current market- What advice he gives to managers - A first-ever lift of the curtain for a sneak peak into Isomer's extremely selective cornerstone program for emerging managers We also want to give a huge shout out to Dimitris Kalavros-Gousiou, founding of Velocity Partners for having invited us to host this talk with Joe Schorge at TEDxAthens this weekend.

Today's episode is a bit different as we're joined by Catherine Dupere, Partner at Isomer Capital and John Dutton, head of the World Economic Forum's Uplink to talk about the Forum's “Innovative Funds for Our Future”-challenge which calls for innovative VC funds who invest in people and planet-focused entrepreneurs that can strengthen innovation ecosystems and strive for the achievement of the 2030 Global Goals. Selected funds will receive the magical recognition and visibility that only highly acclaimed organizations like the WEF can give you. So pay attention to see if this challenge is something for you and apply here

Although we’ve had clearly defined political boundaries since 1836, there’s still an inseparable culture between Texas and Mexico. Whether you call it Tejano or Texican, it’s a give-and-take social process within which Austin’s Graham Reynolds has found a golden opportunity. Graham and the Golden Hornet team have already applied rock production techniques to classical arrangements […]

This week on CUTalks we are talking to Joe Schorge, the founder and managing partner of Isomer Capital, one of Europe's leading Fund-of-Funds based in London UK. Isomer has a broad portfolio underlying more than 1,300 companies from start-ups to unicorns and including 6 IPOs, such as Darktrace, Deliveroo and Acast. Having worked as LP, GP, Angel Investor and Technology Operations Executive in the US and Europe over the last 25 years - Joe holds an impressive career trajectory in VC and private investing with distinguished accomplishments. In this episode, we spoke about Joe's experience of founding Isomer, his path to VC and impact of working in VC, digital finance, Crypto Fund-of-Funds as well as some of the new additions of start-ups in Isomer's portfolio. To find out more about CUTEC, visit www.cutec.io/ This podcast was produced by Carl Homer, Cambridge TV.

Every year I have a tradition of choosing ten targets for the year. After coaching this for the past 5+ years, here are the top 5 things that I have discovered that if you avoid them, can create a phenomenal and fun year!  IN THIS EPISODE, I TALK ABOUT:How my experience at a fast food restaurant pushed me out energetically.How learning and saying someone's name can get you into a state of presence.The question, “How are you?” can be stale and overused that we become zombies and tune out when we ask it.   CLASSES:If you're interested in creating your life AND generating REAL change and potency in 2022, I invite you to join my CREATE YOUR LIFE “Annual Planning Workshop” in January 2022. Text: CREATE to 323-524-9857 to learn about our future dates.  ​​RESOURCES:Text: CREATE to 323-524-9857 to apply for my Get Up Girl Gang community  If you enjoyed this episode, make sure and give us a five star rating  and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox. Let's Connect:The Get Up GirlInstagramFacebookMonthly online fitness academy

Our guest today is Joe Schorge he is the Founder and Managing Partner of Isomer Capital, which is an investment firm based in London and focused exclusively on European venture capital. Isomer accesses high-potential opportunities in European technology through limited partner investments in early stage funds, company co-investments, and secondary purchases of funds and company positions. We speak to him about why he is so excited about emerging managers and what the biggest opportunities and challenges are in the European VC space.

The Stock Day Podcast welcomed Can B Corp. (CANB)(“the Company”), a health & wellness company providing the highest quality hemp derived cannabinoid products. CEO of the Company, Marco Alfonsi, joined Stock Day host Everett Jolly. 

Recently the major enantiomer, or paired molecule, of THC was found in samples of low-THC fiber hemp from Europe. Such a report isn't surprising considering how biochemical processes work. However, this finding could cause a legal ripple capable of sending the hemp industry back to 2019. --- Support this podcast: https://anchor.fm/cannabis-tech/support

Joe Schorge is the founding and managing partner of Isomer Capital, one of the most formative Fund of Funds in the European ecosystem. This is the second part of a two-part episode and this episode focuses on Joe's views on disruption in the VC space, the current state of The European ecosystem and how he assesses emerging managers. To top it off, Joe also left us with some clues of what's coming next for him and for Isomer Capital.In this episode you'll learn:- What it takes to start a VC firm and get interest and money from the best LPs. - Why GPs attempting to disrupt VC rarely catches Joe's interest.- Why being the first and the only is a bad strategy to be fundraising on in VC - How and why Joe and the Isomer team worked close with the founders of First Entrepreneur. - Why LPs should consider investing in a Fund of Funds instead of directly into VC funds.

Joe Schorge is the founding and managing partner of Isomer Capital, one of Europe's absolute strongest Fund of Funds. Joe started his career in technology management positions that got him up close with M&A which led Joe to a whole string of accomplishments in PE and VC doing direct as well as fund investments. To top it off, Joe has also made Angel investments. In this first part of a two-part episode we're truly talking to one of the greats as we dive deep on the origin story of Isomer Capital, Joe's investment thesis and what it takes to be a great VC. In this episode you'll learn:- What made Europe so unique that Joe, as an American, had to start his fund here.- What profiles make up the VC dream team – the VC hackers, hipsters and hustlers.- Why innovation requires an open minded attitude while searching for past patterns.- How Isomer Capital creates value for their portfolio of VC funds.

In this episode we tackle the hot topic of Hemp derived Delta 8 THC, and Isomer of CBD. We will discuss the legal facts surrounding Hemp derived cannabinoids, the August 2020 DEA Memo, and answer the questions on everyone's mind: Is Delta 8 THC Legal?

The science suggests hafnium can't be used to create a gamma ray bomb, but that won't stop the U.S. government from trying.

“You can run an organization where you communicate clearly, and you treat people fairly, and you try to set people up for success. I have seen it work, and I can make that happen, and I remember that it is possible." Hongyi is the Director of Open Government Products, a division of the Government Technology Agency of Singapore. He leads an experimental team of engineers, designers, and product managers who build technology for the public good, such as Data.gov.sg, Parking.sg, FormSG, Go.gov.sg, and Isomer. In this episode, I had an inspiring chat with Hongyi about the Singapore government’s challenges in adopting new tech, including some major hurdles that he needed to overcome at the beginning. Hongyi then shared more about his team, Open Government Products (OGP), how he started the whole initiative, scaled it up, and importantly built some cool products that have brought tremendous impact to the public good. Hongyi also outlined his visions for OGP, that include open sourcing the products that his team has built for other governments to adopt and implement. He also touched on Singapore government’s challenges in terms of cloud adoption and hiring engineering talent. Do not miss Hongyi’s explanation on “bureaucratic deadlock” that he beautifully explained as one of the major challenges that he faced when starting OGP. Listen out for: Hongyi’s career journey - [00:04:36] Singapore government’s challenges in adopting new tech - [00:13:33] The biggest hurdles that Hongyi overcame at the beginning - [00:17:38] Open Government Products (OGP) - [00:21:04] How Open Government Products get approved - [00:24:08] Examples of Open Government Products and the impact - [00:25:38] How Hongyi scaled up OGP - [00:30:11] OGP vision - [00:31:30] Cloud adoption in Singapore government - [00:36:04] Singapore government’s talent challenge - [00:39:42] Hongyi’s 3 Tech Lead Wisdom - [00:42:06] _____ Li Hongyi’s Bio Hongyi is the Director of Open Government Products, a division of the Government Technology Agency of Singapore. He leads an experimental team of engineers, designers, and product managers who build technology for the public good. Projects they work on include Parking.sg, Go.gov.sg, and RedeemSG. Prior to joining the public sector, Hongyi worked at Google on the distributed databases and image search teams. He previously attended MIT, where he obtained degrees in computer science and economics. In his free time, he works on personal projects like typographing.com and chatlet.com. Follow Hongyi: LinkedIn – https://www.linkedin.com/in/hongyi-li-16183230 Our Sponsors This episode is brought to you by JetBrains. Do you want to learn to code? Do you have friends who are looking to learn how to code? Our sponsors at JetBrains recently launched JetBrains Academy, an education platform that offers interactive, project-based learning combined with powerful, professional development tools. Advance your Java and Python skills, with more programming languages to come. To get an extended 3-month free trial on JetBrains Academy, go to https://techleadjournal.dev/jetbrains-academy. Like this episode? Subscribe on your favorite podcast app and submit your feedback. Follow @techleadjournal on LinkedIn, Twitter, and Instagram. Pledge your support by becoming a patron. For more info about the episode (including quotes and transcript), visit techleadjournal.dev/episodes/12.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.13.295642v1?rss=1 Authors: Hata, S., Kikuchi, K., Kano, K., Saito, H., Sobu, Y., Kinoshita, S., Saito, T., Saido, T. C., Sano, Y., Taru, H., Aoki, J., Komano, H., Tomita, T., Natori, S., Suzuki, T. Abstract: Conjugated linoleic acid (CLA) comprises several geometric and positional isomers of the parental linoleic acid (LA). Two of the isomers, cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA) exert various biological activities. However, the effect of CLA on generation of neurotoxic amyloid-{beta} (A{beta}) protein remains unclear. We found that c9,t11CLA significantly suppressed generation of A{beta} in primary cultures of mouse neurons. CLA treatment did not affect the levels of {beta}-site APP-cleaving enzyme 1 (BACE1), a component of active {gamma}-secretase complex presenilin 1 amino-terminal fragment (PS1 NTF), or A{beta} protein precursor (APP) in cultured neurons. BACE1 activity in lysate of neurons treated with c9,t11 CLA, but not t10,c12 CLA, decreased slightly, although c9,t11 CLA did not directly affect the activity of recombinant BACE1. Interestingly, localization of BACE1 and APP in early endosomes increased in neurons treated with c9,t11 CLA; concomitantly, the localization of both proteins was reduced in late endosomes, where APP is predominantly cleaved by BACE1. c9,t11 CLA and t10,c12 CLA appeared to be incorporated into membrane phospholipids, as the level of CLA-containing lysophosphatidylcholine (CLA-LPC) increased dramatically in neurons incubated with CLA. Taken together, our findings indicate that accumulation of c9,t11 CLA-LPC, but not t10,c12 CLA-LPC, in neuronal membranes suppresses amyloidogenic cleavage of APP, thereby contributing to preservation of brain neurons by suppressing neurotoxic A{beta} production in aged subjects. Copy rights belong to original authors. Visit the link for more info

Ep. 83 - Interview with Chris Wade, Partner at Isomer Capital by Scaleup Valley Podcast

In this episode, I am excited to have Samara Anderson on to talk about the effects of stress in the practice of law and the difference proper mitigation of stress can have for the mindful lawyer. Samara is a yoga teacher, Agency of Human Services legal and policy advisor, and an entrepreneur creating a non-profit community farm in Vermont to use farm animals, nature, and mindfulness to heal people. Her legal work has evolved from litigation to public service as an in-house legal and policy advisor with the State of Vermont. Samara has combined her mindfulness practices with the practice of law in her Mindful Practices workshops to reduce stress and increase productivity and happiness.   Topics Covered What brought her to incorporate mindfulness into her law practice, and how to use a mindfulness practice to recognize when you are being reactive and triggered. The effects of stress on the practice of law (the power of the mind to hurt and heal). The power of mindfulness in improving your role as an attorney, and using stress and adrenaline to your advantage. How to be more efficient, productive, happier, and have more integrity as an attorney.   Learn more about Samara at: The Happy Human Projects     Questions? Comments? Email Jeena! hello@jeenacho.com. You can also connect with Jeena on Twitter: @Jeena_Cho For more information, visit: jeenacho.com Order The Anxious Lawyer book — Available in hardcover, Kindle and Audible Find Your Ease: Retreat for Lawyers I'm creating a retreat that will provide a perfect gift of relaxation and rejuvenation with an intimate group of lawyers. Interested? Please complete this form: https://jeena3.typeform.com/to/VXfIXq MINDFUL PAUSE: Bite-Sized Practices for Cultivating More Joy and Focus 31-day program. Spend just 6 minutes every day to practice mindfulness and meditation. Decrease stress/anxiety, increase focus and concentration. Interested? http://jeenacho.com/mindful-pause/ Transcript Intro: [00:00:00] Welcome to The Resilient Lawyer podcast. In this podcast, we have meaningful, in-depth conversations with lawyers, entrepreneurs, and change agents. We offer tools and strategies for creating a more joyful and satisfying life. And now your host, Jeena Cho. Jeena Cho: [00:00:23] Hello my friends, thanks for joining me for another episode of The Resilient Lawyer podcast. In this episode, I am really happy to have Samara Anderson. She is a yoga teacher, Agency of Human Services legal and policy adviser, and an entrepreneur at creating a nonprofit community farm in Vermont to use farm animals nature and mindfulness to heal people. Her legal work has a ball from litigation to public service as an in-house legal and policy adviser with the state of Vermont. Samara has combined her mindfulness practice with the practice of law and her mindfulness practices workshop to reduce stress and increase productivity and happiness and who doesn't want that. Before we get into the interview, if you haven't listened to the last bonus episode go back and check it out. I shared a 6 minute guided meditation practice to let go of stress and anxiety. It's a preview for my new cars mindful pause so often I hear from lawyers that they know they should practice mindfulness but they don't have the time and I was hell lawyer start with just six minutes or point one hour of all the hours you dedicate your client's work and others don't deserve to have at least point one hour to yourself mindful pauses designed for lawyers like it to fit into your schedule. Think of it like taking your daily vitamin to booze show while being head on over to JeenaCho.com to learn more. Or check it out in the shownotes. And with that, here's Samara. Samara, welcome to the show. Samara Anderson: [00:01:48] Awesome thank you. I'm really excited to be here. Jeena Cho: [00:01:51] So let's just start by having you give us a 30 second introduction of who you are and what you know. Samara Anderson: [00:01:57] Well I like to refer to myself as a Yagur so I combining Beany yoga teacher with being a lawyer and that started about five years ago. I started my professional legal career as a complex commercial litigator in Manhattan working on securities fraud antitrust violations products liability. Very very stressful work high stakes very wealthy clients and it was very hostile and you know I kind of transitioned out of that environment into being a yoga teacher thinking I would never practice law again. And then I realized I could actually combine the two. I could bring the mindfulness and the healing that I was feeling both physically and mentally from from yoga and meditation into the practice of law. And so I returned to the practice of law as an assistant attorney general here in Vermont which is where I live now doing some really complex challenging family law cases representing people that were being abused neglected or violated as either adults or children with developmental disabilities. So it was a very stressful kind of situation. But I was able to bring the mindfulness into it and that's made all the difference and now I've kind of transitioned into managing some of their complex projects and representing the agency of Human Services. I'm still you know integrating the two. I teach a lot of mindful practices courses to all types of lawyers Vermont Legal Aid. I teach to other government attorneys law firms. And I'm really passionate about combining these two things and helping other lawyers the less stressed and happier. Jeena Cho: [00:03:51] Well it is combining the two books like they did day basis. Know client by client basis how does that look different than what you were doing previously. Samara Anderson: [00:04:04] I think previously I was just I felt like I was in a rat race. I was just I felt like I was just rushing from one thing to the next. Never really even enjoying whatever it was I was doing even if it was something that could be enjoyable I was just in in those moments. I was thinking of other things are planning the next thing or thinking about something that happened before. And so when I look back at my first seven eight years as a lawyer I was essentially not present at all. I think I was physically present. And my mind was engaged but I wasn't actually there. I think I was always somewhere else. And I think you looking back at you know it just didn't allow me to maximize everything I was doing. But now after you know I have a very solid practice. I incorporate our Iveta into my day as well. So I have in our Ubaid it's called a Jeena Cho area it's a routine that's kind of there to support your body to maximize what you eat when you sleep when you exercise. It's kind of this holistic way of approaching you know your health and that. So those things yoga meditation are kind of all combined to now allow me to be present in all of the moments so I'm really there as much as I can be of course I'm human I'm not. You know I'm not completely enlightened yet but I think the moments of mindfulness and being present are much more powerful and I'm getting a lot more of it out of everything I do. So yeah I think that's the biggest difference just in a kind of a general context. Jeena Cho: [00:05:53] Yeah. And can you talk more specifically about you know when you talk about the power of mindfulness and harnessing it to improve your role as an attorney what that looks like. Can you give a specific example of how you may have handled this situation differently before than you do now. Samara Anderson: [00:06:10] I think that the biggest thing is efficiency and that's really coming from self awareness so you know when you become mindful you become a little bit more self aware. You know you start to realize when you're being triggered you start you starting to realize when you're being reactive. And I think you know the biggest thing is starting to look at both efficiency and sustainability so you know let's say looking at my daily tasks. So before I would be sitting at my desk and e-mails would come in and phone calls would come in and I was just a victim to everyone else contacting me. So if I get a phone call I would answer it if I got an e-mail I would read it if I got to it. This is before the time of cell phones they were just starting to pick up and then now that you know when those cell phones came in I had a BlackBerry and so it was you know e-mail notifications and all these notifications and I was just you know kind of rushing from one thing to the next and getting distracted and not being able to focus on anything that was just you know kind of my mind was jumping from one thing to the next. And now I do what's called batching. So I'll bad I'll let all the e-mails you know just accumulate and I'll have a notification that says I check my e-mails three times a day. So I check them one hour in the morning one hour in the afternoon one hour in the evening. And then you know I take that one hour and it's you know I complete the analysis of all the e-mails looking at the e-mails responding to the e-mails and giving them my full attention. It's the same with phone calls so that the phone calls go to voicemail and then you know Habba time that I've said that I've determined I'm going to you know listen to those phone messages and then I'll listen to them and prioritize the responses and let people know I'll get back to them. So I think it's it's just a different way of of actually practicing. And I think that plays out not just being a lawyer but I think you know anyone in the professional context that that kind of distracted practice is not very efficient or sustainable. Jeena Cho: [00:08:19] So it is one of the things that I often will talk to lawyers about is time management and how to structure their time more efficiently and often I'll get something like well but my clients expected to be available 24/7 and if I don't respond right away they get upset. I'm curious when you started to make these changes. Did you get any pushback. And if so how did you deal with that. Samara Anderson: [00:08:40] Yeah I get that a lot from lawyers especially those that are in the criminal context of the civil litigation context where you've got judges you've got cook you know opposing counsel you've got clients and in one of the things I started to kind of look at I have a government client and I think the key is to set their expectation with the client or the expectation with opposing counsel to state that you know I want to give you all of my attention. And if I respond to your e-mails right away it means I'm not giving you all your all the tension that you know you really deserve. And so I'd rather wait give myself space to like schedule the time to do it. I know there is an emergency. You know I will be available. But typically clients are fine with that. I mean once you set the expectation I mean if the expectation is you're always available then you're you know if that's what they expect then that's what you have to provide. And I've had many lawyers even in the Ledet litigation context as I don't actively practice litigation anymore that are able to actually set those expectations with their clients. So I think that's the key. You know just communicating that upfront. And and you know and then allowing the media negotiation to occur with a client to say well you know if they do have something that's urgent then I'll let that come through. You can set up all these different you know an outlook and different e-mails you can set up certain e-mails can come through with the notification that they're important. So you can actually prioritize things that way. Jeena Cho: [00:10:07] So just not have outlook open during the day when you're not supposed to be checking your e-mail or you sort of internally manage that. Samara Anderson: [00:10:17] I just turn the notifications off. So I mean it's there but I'm not actively looking at it. And I think you know the key is to kind of you know take all your time so if you're you know in the office for eight hours to you know kind of schedule everything. So look down at your calendar and schedule that schedule. You know the break that you're going to take I have a little notification that pops up. Be mindful and it pops up at 1:00 and so it's always like I'm always rushing. That is like. Be mindful. And it's just I can just be mindful for one breath if I don't have the time to take the full five minutes. But usually I can take five minutes and then sometimes it's ten. But you know to really maximize it so if you give if you batched everything you've put everything you know in your calendar then you're just then there's less stress too because you know I'm going to get to this. There's my mind isn't racing to be like how did I do this. Did I do that you've already prioritized everything you already know what you have to do and then you just do it when you schedule it. Jeena Cho: [00:11:13] Yeah. And I think also scheduling things kind of you know it's respecting your own energy right because we don't think you know it's lawyers. We like to think that where we can just work and work and work and work but it's not true. So recognizing that there are only so many hours in the day and you know you're going to prioritize those things that are important and make sure that you are able to do those things when you're sort of at your know optimal energy level and that kind of trying and doing you know for me as you say earlier in the morning tends to be sort of my better hours in terms of getting work done and not putting the most important things to be done at 4:00 o'clock. Oh my energy levels is not going to be as high. Samara Anderson: [00:11:58] Exactly. Or 3 o'clock when all over serotonin and dopamine levels drop later. Jeena Cho: [00:12:06] And you know I think that very nicely kind of leads us into the next topic which has the effect of stress on the practice. Applying this ability of the mind to both hurt and heal so say more about that. Samara Anderson: [00:12:23] I think this is this is something that it kind of developed as I started to teach mindfulness because as a lawyer you know we always kind of want to look at it what's the problem like what is the problem what are we what are we dealing with. And then what is a solution. So as always you know I always start with that kind of a two step analysis. What's the problem. What are my you know possible solutions. And so as I started to break down what had really started to fall apart for me both physically and emotionally it was the effects of stress. And it was the you know the physical and the mental effects of stress. So the example I always use when I write teach my mind for practice practices workshops is I ask all the participants you know what causes stress in your life. And they all you know they have different things and they go around the room and then I say Alright imagine that all the things that you just identified as causing stress your so you're mentally saying these things are causing me stress. Physically your body is reacting as though a supportive tigers chasing you because your mind is telling your body. I'm under stress. There is something that is you know coming after me and it could just be a deadline. It could just be you know a phone call an awkward conversation an argument. And so you know I say well if a saber toothed tigers chasing you what are your options like. What do you need to do. And you know everyone's like run. And I said while you could run or you could you know you could you could fight. You know it may not be the best option but maybe you could. Or you could freeze. And all three of those states cause the same exact amount of hormones in the body. So you've got first nor epinephrine an adrenalin are created. Those are the like. I've got to get out of here. I've got I got get moving. And then and then after that cortisol starts to come online and that stays in the body much longer. But they all are meant to get you to run. You're supposed to be running. So all the blood flow is now going out into your extremities. You know your heart rate increases your respiration it increases your hands could get sweaty. You know and so you're having a stress response. And you know when I tell people that I have them in vision that they're getting chased by sabertooth tiger they start to think wow I actually do kind of feel that way. Like when you and I have a deadline or when I'm under stress it's like my body is reacting that way I could just be sitting in a room thinking about something and my body is going to have that response. And so you know I really talk about how powerful the mind body connection is and it really hits home like you know I'll even do the example of just everyone close their eyes and take your awareness to your left index finger and then I'll have them you know just take their awareness their take their energy there and then open their eyes and say well what did it feel like. Did you feel. What did you feel in your left index finger in there like tingly and it felt like buzzing it felt warm. That is your mind. You're just taking your mind and you're putting it on something. And you know that mind body connection is so powerful and so I say well you know if you've got these stress hormones how how do you decrease them you know how do you kind of get out of the sympathetic nervous system and get into what's called the parasympathetic nervous system and then in that system you've got the other three opposing hormones serotonin dopamine and oxytocin and those actually decrease those stress hormones. So you know mindful practices and there's a lot of documented evidence. Lawyers always want to see the evidence so I always have my studies about you know how deep breathing and mindful movement whatever kind of movement it is. Even if you're running if you're doing it mindfully you'll still have the same facts yoga a tight tchi all of these different motions activate the parasympathetic system and they activate those hormones serotonin dopamine and oxytocin so you actually you've got these I almost kind of see it as like stress hormones versus relaxation hormones and like you know which can you start to increase the relaxation and decrease the stress. And what can you do during the day what can you do in the moment. What can you do to to start to to alter that balance so that you know when someone cut you off in traffic you're not reacting you're just thinking what a person must be having a bad day you know you're your reactive state is much different because you're in he start to cultivate this place of of of more relaxation. So that's kind of how I Jeena I generalize that I have a lot of lawyers say we can handle the talking about the prefrontal cortex I'm like well you know that's probably more advanced mindfulness. Let's just stick with the basics right. And a lot of people are blown away just by the basics right. Because it does have a complex. Jeena Cho: [00:17:17] you explain the actual practice. Can you give one example of a practice of filibusterers and that I like I yeah reading she says is totally making sense. But what do I do in that moment. So you're sitting in the office. The phone rings and says to someone that you like low then you know your heart's racing our stomachs tightening up and you just yell like you can sort of feel that adrenaline kicking in. So what's a practice that you can recommend a lawyer try to do in that moment. Samara Anderson: [00:17:49] Well I think the most critical pieces that you actually are aware that you're having a stress response you know and that in itself is extremely powerful. The second you are realizing wow I am I am I'm I'm really upset right now. I can feel my heart beating faster I can feel my breath rate increasing like you don't want to even talk about stress. I have a lot of lawyers say how many people feel stressed just talking about stress syndrome it raised their hands because even like as you describe that I started feeling it. So you know you know and so the awareness number one that you're having a stress response is extremely powerful. Like that is I think that is probably the key to decreasing your stress is knowing that you're having stress right. You have to know you have to become aware that you have a problem before you can solve it. And then so you realize I'm having a stress response. I'm having a reaction. I think that second piece is is can be very simple and very profound and it's completely free and it's available all the time. It doesn't require any advanced training or any kind of special clothing. It's just your breath. So the second you realize I'm having a stress response. So stress that kind of sympathetic nervous system when it activates that's the inhale. So when I teach yoga when you end it so if you're going to get hit by a car you know you almost get hit and go you know you breathe them. So that's sympathetic system that activates the sympathetic system and usually that happens you look at this phone call or email or you know my mother's calling or whatever could be stressing you out. And and then. So the parasympathetic response is the exhale. So it's. It's letting the breath out. And I think even if you just took one mindful breath like one deep breath in with your eyes closed softening the jaw relaxing the teeth and then one deep exhale out and try linger a little bit in that exhale just that one breath could be enough to have you shift just slightly. It's not going to decrease all the stress hormones. It really depends on how big of a trigger that was. You know how intense the emotion was. But that one breath that could be enough. You know if you still have to take the call you might be a little bit more present because you've just taken two huge steps in mindfulness. Number one you're aware of a stress response. Number two you're trying to become present bring yourself into the moment out of the reactive state. So you know mindfulness is not I'm judgmental it's subjective. You know you're cultivating it which is extremely difficult. You're like sane. I know I have this whole past and I have this you know all these environmental issues and where I was raised and how I was raised and all these things are in me and they alter my perception of reality. But I'm going to try and look at this objectively and try and breathe through the reaction that I'm having so that I can actually be present and non-judgemental. And I think that's I think that's the practice. I mean I guide I guide my students into awareness of their bodies. I mean like really feeling the body. And I think for some people that can be traumatic especially if you've had any kind of abuse in the past. So sometimes coming into the body can be very stressful sometimes you can get the eyes open and just a where the body and then become aware of the breath. So those two things that's mindfulness and it and it's available all the time completely free. Jeena Cho: [00:21:30] You know often when I suggest paying attention to the breath just what you suggested a lot of a lot more so at lawyers and non lawyers they find that that just paying attention to the brand to be very distressing. And you know I think a lot of it just has to do with Ed because we're such control freaks and all of a sudden they are paying attention to this thing that you and doing all of your life. And now that all of these dots are going through it's like am I breathing right. Am I not breathing. And then they start to change your breathing pattern and then they start speed up their breath and all this and act like they can't prevent it. It's just very very distressing so for the listeners out there like you know like pay attention to the press just doesn't work for me. Are there other practices that you can suggest. Samara Anderson: [00:22:16] Well I mean if paying attention to the breath is going to be challenging how is the one thing that I've realized about practices that are challenging it. They're usually there to kind of be our best teacher you know like people that are the most challenging. They're our best teachers you know. You know any kind of practice that I find challenging is my best teacher to say well maybe this is something I really need to look at. But if it's if it's something you absolutely can't do so you're having a really hard time you know doing it alone. Sometimes it works better in a group maybe a guided situation or just use other tools. So instead of focusing on the breath you can focus on the body or you can you know become aware of your surroundings and really start to look around June. What do you see. You could also pay attention to sounds you know eyes are open or closed. I find it easier to pay attention to sound with the eyes closed. I also find it easier to pay attention to sensations in the body with the eyes close. So you know if the brass if trying to and I guess you know what you're talking about is more like a pranayama. So prandial would be breath control you're trying to alter the breath maybe do counties and I've noticed a lot of lawyers when I do accounting so I have them I'll have them count to four on the inhale and I'll have them count to six on the exhale because what I'm trying to do is lengthen the exhale right. So I want to get the parasympathetic system online and I'll have lawyers after it say that was really hard. I start to compete with myself because I'll say well you could do five count inhale and seven count exhale. Or you could do a 6 hour inhale and an eight count accelerate like I was trying to get to succinate and it was so hard and I was really forcing it. And so I think we know because we're so competitive you know we will compete. So if given the opportunity we will start to ratchet it up like five and five and seven is really comfortable for me but succinate is a challenge. I won't push myself and all of a sudden your jaws. You know you're stressing yourself out doing it. And so I say well if that if that practice is stressing you out. And let's try something else let's just try another sense right because what you're trying to do is just bring yourself into the moment. So right. You know take our hands as the breath is the vehicle into the body. So what it does is it brings you if you're in the body you're present like you're here. And so you know if the if there's other ways to get you to into the body that you're out using the breath then you can use those and I find feeling sensations. What does the body feel like. And it's more actually I don't like that word feeling either when you get into some of the verbiage it's better to think about like what is this sensation. What is a sensation in the body because feelings are different. You know there's thoughts and then there's feelings that could be associated with those. Jeena Cho: [00:25:02] Right. Yeah you know words can be tricky. What you may mean by feel or notice or I think maybe didn't know how somebody else explained for that. Samara Anderson: [00:25:12] Yeah. Yeah. Woman is very. Because we're working with lawyers right. And words are our life. So when you start to use a certain word and certain words can be triggering. I find yoga to be triggering. I find meditation to be triggering people like you know what is a some kind of spiritual thing like it and I'm like now you're just focusing on your breath. So it's like I always had to scrub things out so that it's just it's mindfulness you're just mindfully practicing your mindfully moving your mindfully breathing. You know sometimes I do some manual work and so I was like oh what are in it is some kind of seance. It's like no all you're going to do is inhale and think the words Let's exhale go let go. And so I always say the the mind and the body there's no separation of the mind is thinking let go the body will start to let go and then the mind can start to let go of whatever it's holding onto. So you know there's there's lots of little tools and I think you know as I say with yoga it's like and it's the same with the practice of law you take the practice of law. You take the practice of yoga and you add you know add whoever that lawyer is and you get a certain experience and not everyone is going to like every lawyer and not everyone's going to like every yoga teacher and not everyone's going to like every practice. And so I always say if something doesn't work then keep working night. Don't give up on mindfulness just because something didn't resonate for you. Find something that does. You know and maybe it's visualization maybe it's another sense but keep looking because there's something out there that will resonate for you. And then that will be your gateway that will be your path forward into less stress and more happiness. So that's where it's worth looking for. If she can't find it. Jeena Cho: [00:27:06] Yeah that feels like the perfect place to wrap things up. Isomer for. The lesson is out there that want to learn more about you or your work it was the best placement Jeena. Samara Anderson: [00:27:18] The best place is I have a website. It's called The Happy Human projects plural because I didn't really think one would be enough. And it's really a place where you know I teach therapeutic yoga. I teach mindful practice workshops but I also what my biggest passion is is really one on one and group work around mindfulness. And I just I just love working with people and helping them. I feel like I am becoming more mindful. You know as I work with other people you know I learn more as a teacher than I sometimes think my students do so extremely you know passionate about that I travel all over the country teaching. So I would love to have people connect with me. Jeena Cho: [00:27:59] Wonderful. One final question before I let you go. What does it mean to be a resilient lawyer. Samara Anderson: [00:28:07] I think they are resilient lawyers really honoring everything that that has taken you to where you're at. You know it's honoring all of the all the horrible things that might have happened to you as in your legal practice. All the wonderful wins that you had and kind of looking at all of that as you know your teacher. You know I'm so glad that I worked in a very challenging stressful legal practice where I was building you know 3000 hours a year because if I hadn't done that I would not have come to a place of of mindfulness. And so I think being resilient is honoring everything that that that has happened to you that has gotten to you to where you're at. And then you're using it and you're maximizing it to maximize your life. So I think that's for me that's what resilient lawyer and resiliency in general mean wander smile. Jeena Cho: [00:28:58] Thank you so much for joining me today. Really appreciate it. Samara Anderson: [00:29:02] Thank you I really enjoyed it. Closing: [00:29:10] Thanks for joining us on The Resilient Lawyer podcast. If you've enjoyed the show please tell a friend. It's really the best way to grow the show to leave us a review on iTunes search for The Resilient Lawyer and give us your honest feedback. It goes a long way to help with our visibility when you do that. So we really appreciate it. As always we'd love to hear from you. E-mail us at smile at the anxious lawyer dot com. Thanks and look forward to seeing you next week.

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In lebenden Organismen spielen Proteine eine wichtige Rolle bei Stoffwechselvorgängen. Für ihre Funktion ist die dreidimensionale Anordnung der Aminosäurekette von entscheidender Bedeutung. Um die frühen Faltungsprozesse von bestimmten Sekundärstrukturelementen zu analysieren, ist die Verwendung von Modellpeptiden nötig, da hier die Bildung solcher Strukturelemente getrennt beobachtet werden kann. Der Einbau eines optischen Schalters wie Azobenzol in Modellpeptide ermöglicht durch dessen lichtgetriebene cis/trans Isomerisierung eine Auslösung der Faltungsprozesse auf ultrakurzer Zeitskala (< 10 ps). Ein wesentliches Merkmal der Kombination dieses Photoschalters mit der in dieser Arbeit verwendeten Methode der UV-Anreg-Infrarot-Abtast-Spektroskopie ist die Möglichkeit, Zwischenzustände, sogenannte Intermediate, zeitlich einordnen und mittels ihrer Infrarotspektren Aussagen über ihre Struktur treffen zu können. Als Modell für das Sekundärstrukturelement des beta-Faltblatts dient eine beta-Hairpin Struktur. Diese Struktur besteht aus zwei anti-parallelen Aminosäuresträngen, welche durch Wasserstoffbrückenbindungen verbunden sind. Eine Kehre aus vier Aminosäuren schließt die Stränge auf einer Seite ab. Als photoschaltbares beta-Hairpin Modellpeptid wurde im Rahmen dieser Arbeit das AzoTrpZip2 mit der Sequenz H-Ser-Trp-Thr-Trp-Glu-AMPP-Lys-Trp-Thr-Trp-Lys-NH2 eingesetzt, wobei AMPP eine auf Azobenzol basierende pseudo-Aminosäure bezeichnet. Das Peptid AzoTrpZip2 bildet als cis-Isomer zu 45 % im Lösungsmittel Methanol-d4 eine beta-Hairpin Struktur aus. Das cis-Isomer des AMPPs ersetzt dabei zwei Aminos¨auren der Kehre. Das Ensemble an trans-Isomeren des AzoTrpZip2 hingegen besitzt eine deutlich weniger definierte Struktur. Ausgelöst durch die Isomerisierung des Schalters AMPP beginnt die Entfaltung der beta-Hairpin Struktur des AzoTrpZip2 mit einem reißverschlussartig sich fortsetzenden Bruch der schalternahen Wasserstoffbrückenbindungen und der Bildung eines desolvatisierten Zustandes mit einer Zeitkonstante von 4,1 ps. Mit 26 ps entsteht ein weiteres Intermediat, das mit einer Zeitkonstante von 630 ps in einer Klappbewegung mit den Strangmitten als Scharnier in einen Zustand übergeht, der dem Endzustand des trans- Ensemble ähnlich ist. Die Entfaltung ist nach 3 ns also weitgehend abgeschlossen. Auch bei der Faltungsreaktion erfolgt die Isomerisierung des Photoschalters auf der Pikosekundenzeitskala. Somit ist die zentrale Kehre der beta-Hairpin Struktur bereits innerhalb weniger Pikosekunden ausgebildet. Ähnlich wie bei der Entfaltung wird mit einer Zeitkonstante von 4,8 ps ein desolvatisierter Zustand erreicht, der mit einer Zeitkonstante von 64 ps in ein Faltungsintermediat übergeht. Daraus wird mit der Faltungszeitkonstante von 30 µs die beta-Hairpin Struktur gebildet. Die in der Literatur kontrovers diskutierte Frage nach dem geschwindigkeitsbestimmenden Schritt konnte für dieses Modellpeptid geklärt werden: Es ist die korrekte Anordnung der Wasserstoffverbrückung der Stränge und nicht die Ausbildung der Schleife.

Fulgide gehören zu den photochromen molekularen Schaltern auf der Basis eines 6-elektrozyklischen Systems. Ihre ausgeprägte Photochromie wird von einer photoinduzierten, reversiblen Ringöffnung bestimmt: Das farbige Isomer mit geschlossenem Ring wird dabei durch sichtbares Licht in ein farbloses, offenes Isomer überführt. Mithilfe der transienten Absorptionsspektroskopie im UV/VIS und im mittleren IR konnten in der vorliegenden Arbeit entscheidende Fortschritte im Verständnis der perizyklischen Ringöffnung von Fulgiden und von chemisch nahe verwandten Fulgimiden erreicht werden. Erstmals konnte die Kinetik der Ringöffnungsreaktion im Detail vermessen und damit der Reaktionsweg der Ringöffnung aufgeklärt werden: Die Messergebnisse deuten auf einem Modell mit einer direkten photochemischen Umwandlung auf der Zeitskala von wenigen Pikosekunden und ohne langlebige Intermediate hin. Nach Anregung des geschlossenen Isomers in den angeregten S2-Zustand alternative Reaktionspfade abläuft. Die Mehrheit der S2-angeregten Moleküle beschreiten einen direkten Reaktionsweg, während nur etwa 40% die bekannte Abfolge (Kasha-Regel) der molekularen Prozesse für Photoreaktionen aus höheren elektronischen Zuständen durchlaufen: Zunächst erfolgt eine Relaxation in den niedrigsten elektronisch angeregten Zustand und von dort die „normale“ S1-Photochemie. Weiter werden die Auswirkungen optischer und thermischer Überschussenergie auf die Quanteneffizienz der Ringöffnungsreaktion der Fulgide untersucht. Ein einfaches Modell auf der Basis der Arrhenius-Gleichung wird entwickelt, das davon ausgeht, dass beide Arten der Energiezufuhr eine äquivalente photochemische Wirkung zeigen, dass also optische Überschussenergie sehr schnell thermalisiert. Zentrales Element ist dabei ein Konversionskoeffizient, der es in linearer Näherung erlaubt, optische Überschussenergie in zusätzliche thermische Energie umzurechnen. Im Zusammenhang mit potentiellen Anwendungen ist es gelungen, den Prototyp eines extrem schnellen, rein optischen Schreib/Lese/Lösch/Lese Operationszyklus auf molekularer Basis zu realisieren. Dieses „proof of principle“ Experiment demonstriert, dass die einzelnen Elemente des Zyklus basierend auf photochromen Fulgiden mit einer Taktrate von 250 GHz kombiniert werden können.

Das Hauptaugenmerk dieser Arbeit ist auf das extrem seltene Isotop 180Ta gerichtet. 180Ta ist eines der wenigen Isotope, dessen Nukleosynthese unklar ist. Als weitere Besonderheit liegt 180Ta in der Natur in einem isomeren Zustand vor. Eine wichtige Fragestellung dieser Arbeit ist, ob Zwischenzust¨ande im 180Ta existieren, die das Isomer mit dem unstabilen Grundzustand koppeln. Die Existenz solcher Zustaende kann Auswirkungen auf die Nukleosynthese von 180Ta in heißen Entstehungsszenarien wie dem s-Prozess haben, da ueber thermisch anregbare Zwischenzustaende das Isomer in den Grundzustand entvoelkert werden koennte. Durch Coulombanregung sollten moeglichst viele Zust¨ande im 180Ta entdeckt und auf ihr moegliches Wirken als Zwischenzustaende untersucht werden. Im ersten Teil der Arbeit wird ein zu diesem Zweck am Niels-Bohr-Institut in Risø, Daenemark, durchgefuehrtes Coulombanregungs-Experiment beschrieben, bei dem 180Ta erstmals gammaspektroskopiert werden konnte. Ein an 180Ta angereichertes und ein nicht angereichertes Tantaloxidtarget wurden mit 58Ni-Projektilen mit einer Energie von 225 MeV bestrahlt. Durch den Vergleich dieser Spektren konnten die auf dem Isomer im 180Ta aufbauende Rotationsbande sowie Zust¨ande, die wahrscheinlich zu zwei γ-Vibrationsbanden gehoeren, gefunden werden. In dem mitspektroskopierten Isotop 181Ta konnten neue Uebergaenge entdeckt werden, die den bisher unbekannten γ-Vibrationsbanden zugeschrieben werden. Aus den gemessenen γ-Intensitaeten wurden die Uebergangsmatrixelemente zwischen den gefundenen Zustaenden von 180Ta und 181Ta bestimmt. Der zweite Teil der Arbeit stellt ein am Muenchener Tandem-Beschleuniger durchgef uehrtes Aktivierungsexperiment zur Suche nach Zwischenzustaenden im 180Ta vor. In diesem Experiment wurden angereicherte und nicht angereicherte Tantaloxidtargets mit 36S- und 64Ni-Projektilen bei verschiedenen Energien bestrahlt und die gestreuten 180Ta-Kerne in Folien aufgefangen. Nach der Bestrahlung waren in den Folien Grundzustandszerf¨alle von 180Ta-Kernen nachweisbar. Das Experiment zeigt, dass Coulomb-anregbare Zwischenzustaende im 180Ta existieren, die das Isomer mit dem Grundzustand koppeln. Um die Multipolaritaet der Anregung und die Energie der Zwischenzustaende zu bestimmen, wurden fuer drei Kopplungsmodelle (K-verbotenes-, γ-Vibrations- und Oktupol-Vibrations-Kopplungsmodell) die ¨Ubereinstimmung mit den experimentellen Daten getestet. Im dritten Teil der Arbeit wird die Nukleosynthese von 180Ta im s-Prozess mit und ohne Beruecksichtigung von Zwischenzustaenden diskutiert. Die Rechnungen im Fall von Zwischenzustaenden zeigen, dass die Nukleosynthese von 180Ta durch den klassischen s-Prozess erklaert werden koennte.

1. Propargylkationen - Erzeugung, Struktur und Reaktivität In Anlehnung an die literaturbekannte Addition [71] eines Lithiumacetylids an ein Aldehydderivat werden unter zusätzlicher Chromtricarbonylaren-Komplexierung diastereomerenreine Substratvorläufer 91 erhalten. Mit dem Ziel, die relevanten Einflußfaktoren und Stabilisierungsmechanismen für eine stereo- und regioselektive kationische Propargylierungsreaktion mit den ortho-substituierten planar chiralen Systemen 91 zu ermitteln, wird die Reaktionssequenz der formalen nucleophilen Substitution in ihre Einzelschritte zerlegt (Ionisation und nucleophile Addition). Die Ionisation der gelben Acetate 77 (entspricht 91 mit R1 = H, R2 = C6H5) bzw. 91 (R1 ¹ H) zu den purpurrot- bis violettfarbigen übergangsmetallstabilisierten Propargylkationen 17 (R1 = H, R2 = C6H5) bzw. 92 (R1 ¹ H) wird zwischen -70 und -40 °C in Dichlormethan durchgeführt und NMR- bzw. UV/Vis-spektroskopisch untersucht (Schema 0.1). Dabei stellt man fest, daß unter der Voraussetzung einer ausreichend starken Lewis-Säure bei tiefen Temperaturen zunächst unter kinetischer Kontrolle das konformativ fixierte s-syn- Propargylkation 92 (R1 ¹ H) irreversibel unter Nachbargruppenbeteiligung des Chroms erzeugt wird, das jedoch bei höheren Temperaturen zum thermodynamisch günstigeren s-anti- Isomer 92' isomerisiert. Aus den Geschwindigkeitskonstanten zweiter Ordnung und den bekannten N- und s- Parametern der eingesetzten Nucleophile (Allyltrimethylsilan, Allylchlordimethylsilan, Anisol, Dimethylphenylsilan) wird mit Mayrs Gleichung [lg k (20°C) = s (E + N)] [103] der Elektrophilie-Parameter E für das Propargylkation 17 (R1 = H, R2 = C6H5) zu E = 1.24 ± 0.39 ermittelt und in seiner Reaktivität mit verwandten Propargylsystemen verglichen (z.B. Nicholas-Kationen E = -1.34 und g-(aren)Cr(CO)3-substituierten Propargylkationen E = -0.35). 2. Diastereoselektive Propargylierungsreaktion Planar chirale ortho-(aren)Cr(CO)3-stabilisierte Propargylkationen 92 reagieren mit einer Vielzahl von O-, S-, N- und p-Nucleophilen regioselektiv zu den entsprechenden Propargylderivaten 93 in guten Ausbeuten (65 bis 90 %) und ausgezeichneten Diastereoselektivitäten (93 : 93' mit d.r. > 9 : 1) (Schema 0.2). Die relative Stereochemie der Produkte wird anhand zahlreicher Kristallstrukturanalysen manifestiert und auf Basis eines Doppel-Inversions-Mechanismus unter Retention der Konfiguration am Propargylzentrum erklärt. Ein Arylsubstituent an der g-Position (R2) steigert die Stabilität der kationischen Zwischenstufe 92, aber auch 92e mit einem g-Alkylsubstituenten wird erfolgreich in der diastereoselektiven nucleophilen Substitutionsreaktionen eingesetzt (Tabelle 0.1). Nur starke Lewis-Säuren ermöglichen durch eine irreversible Ionisation die bevorzugte Bildung des Diastereomers 93 (Tabelle 0.1, siehe Ionisation des Propargylacetats 91e mit unterschiedlichen Säuren). Die Diastereoselektivität wird zudem durch die Stabilität des Propargylkations (92a > 92b-e) und die Reaktivität des angreifenden Nucleophils (Amin ³ Thiol > Silylenolether) erhöht. (Tabelle 0.1). Die stufenseparierte nucleophile Substitution ist unumgänglich, weil bei der in situ-Ionisation des Acetats 91e mit einer starken Lewis-Säure (TiCl4) unter gleichzeitiger Anwesenheit des Nucleophils 110f eine Verringerung der Selektivität (d.r. = 34 : 66) sowie eine Selektivitätsumkehr zugunsten des thermodynamisch kontrollierten Produkts 93' resultiert. 3. Diastereofaciale Selektivität Es kann gezeigt werden, daß der Angriff eines prostereogenen Nucleophils an ein (aren)Cr(CO)3-substituiertes und damit konfigurationsstabiles Propargylkation 92a mit einer Vorzugsorientierung einhergeht (Schema 0.3). Mehrere stereochemisch kontrollierende Elemente (durch den Chromtricarbonyltripoden einseitig abgeschirmtes Kation und prostereogenes Nucleophil) ergeben neben der einfachen stereochemischen Kontrolle des Propargylzentrums auch eine hohe diastereofaciale Selektion bezüglich des zweiten neu generierten Stereozentrums zum Produkt 121. Im Fall des 1-Morpholinocyclohexens (110h) und -pentens (110i) erreicht man in guten Ausbeuten (59 und 68 %) und ausgezeichneten Selektivitäten von d.r. = 88 : 22 und 94 : 6 die Ketone 126a und 127b. In der Reaktion des acyclischen Aminoacrylats 110m und anschließender Reduktion kann ebenfalls in beachtlicher Selektivität von d.r. = 80 : 20 das entsprechende Produkt 131 gewonnen werden. Kristallstrukturanalysen stützen die Zuordnung der relativen Stereochemie der Stereozentren. 4. Versuch einer sukzessiven asymmetrischen Induktion auf drei stereogene Zentren Nach der Addition des 1-Morpholinocyclohexens (110h) an das aus dem Propargylacetat 91a erzeugte Kation und abschließenden Reduktion des intermediären Iminiumions 134 wird das dritte, benachbarte Stereozentrum nur mit einer geringen Stereodifferenzierung (d.r. = 55 : 45) gebildet (Schema 0.4). Jedoch deutet die Entstehung von lediglich zwei Diastereomeren 135 darauf, daß die Propargyl- sowie die Homopropargylzentren hochgradig stereoselektiv entstanden sein müssen. 5. Bemerkenswerte Amphoterie der propargylsubstituierten Arentricarbonylchrom- Komplexe Die elektronisch hermaphroditische Natur der (Aren)Cr(CO)3-Komplexe wird bei der Darstellung eines stabilisierten Propargylanions 137a (-25 °C, THF) in einer einzigartigen Reaktionssequenz zur Seitenkettenfunktionalisierung genutzt (Schema 0.5). In einer sukzessiven Reaktionsfolge wird die Vorstufe 78d über die in dieser Arbeit entwickelten kationischen Propargylierungsreaktion mit Anisol (110d) als Nucleophil hergestellt. Das Propargylderivat 78d wird ohne zusätzliche Einführung von Elektronenakzeptoren direkt mit Lithiumhexamethyldisilazid in das Propargylanion 137a übergeführt, das dann der elektrophilen Addition von Methyliodid zum Propargylderivat 138a unterzogen werden kann. Die Additionen von Protonen oder Trimethylsilylchlorid liefern hingegen nach ausschließlichem g-Angriff die entsprechenden Allene 139 in guten Ausbeuten um 70 %. Die anionische Zwischenstufe 137a kann bei tiefen Temperaturen in Tetrahydrofuran sowohl NMR- als auch UV/Vis-spektroskopisch nachgewiesen werden. 6. Ungewöhnliche Propargyl-Allenyl-Isomerisierung in den Abfangreaktionen der Propargylkationen Anstelle der erwarteten Propargylderivate 93 liefert die Addition des Triphenylphosphans 140 an die (aren)Cr(CO)3-substituierten Propargylkationen 17 bzw. 92 die Allenylphosphoniumsalze 141 (Schema 0.6). Diese ungewöhnliche Reaktionssequenz in saurem Medium, die man bei der nucleophilen Addition des Phosphans an das Kation 17 bzw. 92 beobachtet, kann über eine konsekutive, wahrscheinlich prototropische Isomerisierung gedeutet werden. Die Strukturen der komplexsubstituierten Allenylphosphoniumsalze 141 werden mit der NMR-Spektroskopie und zusätzlich über Röntgenstrukturanalysen von 141b und 141c unzweifelhaft identifiziert. Die Produktverhältnisse der als Diastereomere erhaltenen Phosphoniumsalze 141b und 141c lassen auf keinen stereochemisch induzierten Verlauf bei der nachgeschalteten prototropen Isomerisierung schließen. 7. Regioselektiver a-Angriff der Thiole an mono- und disubstituierte (Aren)Cr(CO)3- Propargykationen Während die ortho-substituierten Arylpropargylkationen 92 (R1 ¹ H und unabhängig vom g-Substituenten R2) mit Thiolen die erwarteten Propargylthioether 118 bilden, entstehen bei dem monosubstituierten Vertreter 17 (R1 = H) die Allenylthioether 79 (Schema 0.7). Die Anwesenheit eines ortho-Substituenten R1 unterbindet vermutlich aus sterischen Gründen eine Folgereaktion der Alkine zu den thermodynamisch stabileren Allenen. Kristallstrukturanalysen untermauern neben der NMR-Spektroskopie die a-Verknüpfung der Propargyleinheit mit dem eingesetzten Thiol. Der gelbe Allenylthioether 79c ergibt nach einer Kristallisationsdauer von mehreren Wochen aus Acetonitril bei 0 °C rote Einkristalle eines einzigen [2+2]-Additionsprodukts 144 der angegebenen Stereochemie, dessen Struktur mittels der Kristallstrukturanalyse aufgeklärt werden kann (Schema 0.8). 8. Totalsynthese des rac-O,O'-Dimethylethers des pharmakologisch interessanten Hinokiresinols Aufbauend auf der etablierten, hochgradig stereoselektiv geführten Propargylierungsreaktion über ein (aren)Cr(CO)3-substituiertes Propargylkation 92 wird eine neuartige Totalsynthese zu einem Derivat 153b des pharmakologisch bedeutenden und in der Natur vorkommenden Hinokiresinols vorgestellt (Schema 0.9). Im Schlüsselschritt wird ein E-Vinylsilan an das aus dem Acetat 188a bei -78 °C generierte Propargylkation 189 addiert. Neben der beachtlich hohen Ausbeute von 36 % über acht lineare Syntheseschritte bietet dieser Syntheseweg die Möglichkeit, unter Verwendung enantiomerenreinen Ausgangsmaterials 188a die Synthese enantioselektiv zu führen sowie durch die Addition des entsprechenden Z-Vinylsilans den isomeren Nyasoldimethylether darzustellen.