Podcasts about why we don't have to

Brutális mélyre merülés Tábori VIktor elméjébe közel 3 órában. Viktor úgy döntött, az életét arra szenteli, hogy 1000 életet éljen meg egy emberöltő alatt. Ő így tanul, így érzi jól magát, ez tartja motiváltan. Mentális modellek, AI, sport és a hosszú élet titka, proteinek, böjtölés, új célország választás adatalapon, a siker és a depresszió kapcsolata, paprikaszósz készítés tudományos alapon, és még számtalan dolog, ami Viktort jellemzi, és amiken keresztül megéli ezt a sok-sok dolgot, ami másoknak egy életre is bőven sok élmény és tapasztalat lenne. Linkek az adásból: - "Hellicious" a márkája a csípősszósznak amit kóstoltunk - hogyan fermentálj saját chili-t vagy kimchi-t: https://www.youtube.com/watch?v=iiNl0Jv6xTw - Longevity, böjtölés, fehérje bevitel: The Longevity Solution: Rediscovering Centuries-Old Secrets to a Healthy, Long Life https://www.amazon.com/The-Longevity-Solution-audiobook/dp/B07RVCZSXK/ Outlive: The Science and Art of Longevity https://www.amazon.com/Audible-Outlive-Science-Art-Longevity/dp/B0B64WL9PK/ Lifespan: Why We Age - and Why We Don't Have To https://www.amazon.com/Lifespan-audiobook/dp/B07QGH1Q43/ Aktuális kurzusajánlatunk BB hallgatóknak a LABA-tól: https://cutt.ly/CwcObCfZ Adi Myprotein-nagyköveti kedvezményes linkje sportruházatra és táplálék-kiegészítőkre (10-20% állandó, 20-40% eseti kedvezménnyel): https://prf.hn/l/NJ1Ze4X VOIZ hangoskönyv app 50%-os kedvezmény az első hónapra: https://bizniszboyz.hu/voiz Impulzus Hírlevél: https://impulzushirlevel.hu

David Sinclair is a professor of genetics at Harvard Medical School and the founder of the Sinclair Lab. He's the author of the bestselling book Lifespan: Why We Age—and Why We Don't Have To, as well as a founder of several biotech companies. Auren and David discuss the potential to expand the average human lifespan by decades. David challenges traditional notions of aging and emphasizes the need to embrace new technologies. They also discuss the benefits and drawbacks of common anti-aging practices like interval training, fasting, and stress reduction. David shares his thoughts on what longevity medicines and supplements are most beneficial, and how to talk to your doctor about them. He breaks down which health metrics to monitor in treating and preventing aging. Overall, David offers an incredibly optimistic vision for what the future of aging could look like, and the science it will take to get there. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and David Sinclair on Twitter at @davidasinclair 

He gave up a staggeringly successful career to live a quiet life -- and now he shares his wisdom with us. Murali Neelakantan joins Amit Varma in episode 329 of The Seen and the Unseen to talk about the life he has lived and the lessons he has learnt. (FOR FULL LINKED SHOW NOTES, GO TO SEENUNSEEN.IN.) Also check out: 1. Murali Neelankantan on Twitter and LinkedIn. 2. An Idea of a Law School -- NR Madhava Menon, Murali Neelakantan and Sumeet Malik. 3. Akshaya Mukul and the Life of Agyeya -- Episode 324 of The Seen and the Unseen. 4. The Life and Times of Shanta Gokhale — Episode 311 of The Seen and the Unseen. 5. Wanting — Luke Burgis. 6. It is immoral to have children. Here's why — Amit Varma. 7. The Loneliness of the Indian Woman — Episode 259 of The Seen and the Unseen (w Shrayana Bhattacharya). 8. The Life and Times of Mrinal Pande — Episode 263 of The Seen and the Unseen. 9. Sara Rai Inhales Literature — Episode 255 of The Seen and the Unseen. 10. Casino Royale -- Martin Campbell. 11. Schrödinger's cat. 12. Dance Dance For the Halva Waala — Episode 294 of The Seen and the Unseen (w Jai Arjun Singh and Subrat Mohanty). 13. Right to Education: Just another law -- Meera Neelakantan. 14. The Life and Times of Abhinandan Sekhri — Episode 254 of The Seen and the Unseen. 15. The Forgotten Greatness of PV Narasimha Rao — Episode 283 of The Seen and the Unseen (w Vinay Sitapati). 16. The Prem Panicker Files — Episode 217 of The Seen and the Unseen (w Prem Panicker). 17. Major Navneet Vats SM. 18. Lifespan: Why We Age – and Why We Don't Have To — David Sinclair. 19. The Lifespan Podcast by David Sinclair. 20. The Adda at the End of the Universe — Episode 309 of The Seen and the Unseen (w Vikram Sathaye and Roshan Abbas). 21. Loss Aversion. 22. Aandhi -- Gulzar. 23. Nowhere Near -- Yo La Tengo. 24. Dil Hi To Hai Na Sang o Hishat -- Abida Parveen. 25. Ranjish hi Sahi -- Mehdi Hasan. 26. Old Man -- Neil Young. 27. Oscar Wilde on Amazon and Wikipedia. 28. Tum Itna Jo Muskura Rahe Ho -- Jagjit Singh. 29. Bonjour Tristesse -- Françoise Sagan. 30. Everybody Lies — Seth Stephens-Davidowitz. 31. Politics and the Sociopath (2014) — Amit Varma. 32. History of European Morals — WEH Lecky. 33. The Expanding Circle — Peter Singer. 34. Dunbar's number. 35. Rankthings.io by Aella and David. 36. Aella on Twitter and Substack. 37. Ye Humse Na Hoga -- Javed Akhtar. 38. All You Who Sleep Tonight -- Vikram Seth. 39. GCN +. 40. The Gentle Wisdom of Pratap Bhanu Mehta — Episode 300 of The Seen and the Unseen. 41. The Life and Times of Jerry Pinto — Episode 314 of The Seen and the Unseen. 42. SVB, Banking and the State of the Economy -- Episode 323 of The Seen and the Unseen (w Ajay Shah and Mohit Satyanand). 43. Ashutosh Salil and the Challenge of Change -- Episode 312 of The Seen and the Unseen. 44. Laws Against Victimless Crimes Should Be Scrapped — Amit Varma. 45. One Bad Law Goes, but Women Remain Second-Class Citizens — Amit Varma. 46. ये लिबरल आख़िर है कौन? — Episode 37 of Puliyabaazi (w Amit Varma, on Hayek). 47. Elite Imitation in Public Policy — Episode 180 of The Seen and the Unseen (on isomorphic mimicry, with Shruti Rajagopalan and Alex Tabarrok). 48. The Long Road From Neeyat to Neeti — Episode 313 of The Seen and the Unseen (w Pranay Kotasthane and Raghu S Jaitley). 49. Narendra Shenoy and Mr Narendra Shenoy — Episode 250 of The Seen and the Unseen. 50. Restaurant Regulations in India — Episode 18 of The Seen and the Unseen (w Madhu Menon). 51. The Wealth of Nations -- Adam Smith. 52. The Theory of Moral Sentiments — Adam Smith. 53. Humesha Der Kar Deta Hoon Main -- Muneer Niazi. 54. The Economics and Politics of Vaccines — Episode 223 of The Seen and the Unseen (w Ajay Shah). 55. Rustom -- Tinu Suresh Desai on the Nanavati case. 56. Natasha Badhwar Lives the Examined Life — Episode 301 of The Seen and the Unseen. 57. The Nurture Assumption — Judith Rich Harris. 58. Mohit Satyanand on Twitter and Substack. 59. Episodes of The Seen and the Unseen with Mohit Satyanand: 1, 2, 3, 4, 5, 6. 60. Richard Dawkins on unpleasant gods. 61. Pushpesh Pant Feasts on the Buffet of Life -- Episode 326 of The Seen and the Unseen. 62. Three Hundred Verses: Musings on Life, Love and Renunciation -- Bhartrihari. 63. Drug Price Controls -- Episode 29 of The Seen and the Unseen (w Pavan Srinath). 64. The Dark Side of Indian Pharma — Episode 245 of The Seen and the Unseen (w Dinesh Thakur). 65. Bottle of Lies — Katherine Eban. 66. The Truth Pill: The Myth of Drug Regulation in India -- Dinesh Thakur and Prashant Reddy. 67. Fire in the Blood -- Dylan Mohan Gray. 68. New York Stories -- Martin Scorcese, Francis Ford Coppola and Woody Allen. 69. The Ideas of Our Constitution — Episode 164 of The Seen and the Unseen (w Madhav Khosla). 70. Kumārasambhava -- Kalidasa. 71. Quiet: The Power of Introverts in a World That Can't Stop Talking -- Susan Cain. 72. Goodbye, Mr Chips -- Sam Wood. 73. Hitler's SS: Portrait in Evil -- Jim Goddard. 74. What Money Can't Buy -- Michael Sandel. 75. Tum Bilkul Hum Jaise Nikle -- Fehmida Riaz. 76.  Kuchh Log Tumhein Samjhaaenge -- Fehmida Riaz. 77. The Four Quadrants of Conformism — Paul Graham. Check out Amit's online course, The Art of Clear Writing. And subscribe to The India Uncut Newsletter. It's free! Episode art: ‘This is the World' by Simahina.

He's a guitarist, a composer, a producer, an audio engineer and a teacher. Gaurav Chintamani joins Amit Varma in episode 316 of The Seen and the Unseen to share his reflections on music and life. (FOR FULL LINKED SHOW NOTES, GO TO SEENUNSEEN.IN.) Also check out: 1. Gaurav Chintamani at Instagram, Twitter, LinkedIn, SACAC and his own website. 2. Advaita on YouTube Music, YouTube, Spotify, Instagram and Twitter. 3. Raman Negi on YouTube Music, YouTube, Spotify, Instagram and Twitter. 4. The Dirt Machine on YouTube Music, YouTube and Spotify. 5. Grounded in Space -- Advaita. 6. The Silent Sea -- Advaita. 7. Shaksiyat -- Raman Negi. 8.  Mehroom -- Raman Negi. 9. Lullaby for the Anxious Bones -- Raman Negi. 10. It's About Time -- The Dirt Machine. 11. Kleptocrat -- The Dirt Machine + Amartya Ghosh (The song that started with dripping water). 12. Carol of the Bells -- Ishaan Chintamani. 13. Gaurav Chintamani on the School of Bass Podcast. 14. The Life and Times of Shanta Gokhale — Episode 311 of The Seen and the Unseen. 15. Hard work vs. Long work -- Seth Godin. 16. Warren Mendonsa Plays the Universal Pentatonic — Episode 273 of The Seen and the Unseen. 17. The Beatles on YouTube Music, Spotify and Wikipedia. 18. Bob Dylan on YouTube Music, Spotify and Wikipedia. 19. Choo Lo -- The Local Train. 20. Episodes of The Seen and the Unseen on the creator ecosystem with Roshan Abbas, Varun Duggirala, Neelesh Misra, Snehal Pradhan, Chuck Gopal, Nishant Jain, Deepak Shenoy and Abhijit Bhaduri. 21. Four Thousand Weeks -- Oliver Burkeman. 22. Redemption Song -- Bob Marley. 23. The Beach (book) -- Alex Garland. 24. The Beach (film) -- Danny Boyle. 25. John Cage on YouTube Music, Spotify and Wikipedia. 26. A Scientist in the Kitchen — Episode 204 of The Seen and the Unseen (w Krish Ashok). 27. Over the Hills and Far Away -- Led Zeppelin. 28. Amit Varma's favourite lofi playlists on YouTube and Spotify. 29. Music for Airports -- Brian Eno. 30. The Formula Behind Every Perfect Pop Song — Seeker. 31. The Double ‘Thank-You' Moment — John Stossel. 32. Deezer -- The French streaming service that Gaurav mentions. This is how they pay their artists. 33. Entry and Exit in Agriculture -- Episode 1 of The Seen and the Unseen (w Pavan Srinath and Karthik Shashidhar). 34. Altitude -- Advaita on The Dewarists. 35. A Hard Day's Night -- The Beatles. 36. Thriller -- Michael Jackson. 37. Guns N' Roses, Pantera and The Doors. 38. The Sky is Crying -- Stevie Ray Vaughan. 39. Jai Arjun Singh Lost It at the Movies — Episode 230 of The Seen and the Unseen. 40. Lou Majaw on YouTube Music and Spotify. 41. Acquired Senses (a demo version) -- HFT. 42. Natasha Badhwar Lives the Examined Life — Episode 301 of The Seen and the Unseen. 43. Suyash Rai Embraces India's Complexity -- Episode 307 of The Seen and the Unseen. 44. Jeff Beck on YouTube Music, Spotify and Wikipedia. 45. Jimi Hendrix on YouTube Music, Spotify and Wikipedia. 46. Imposter Syndrome. 47. Aakar Patel on Twitter. 48. A Meditation on Form — Amit Varma. 49. Wanting — Luke Burgis. 50. René Girard on Amazon and Wikipedia. 51. Lifespan: Why We Age – and Why We Don't Have To — David Sinclair. 52. Waking Up - A New Operating System for Your Mind -- Sam Harris. 53. The Adda at the End of the Universe — Episode 309 of The Seen and the Unseen (w Vikram Sathaye and Roshan Abbas). 54. Dirty Mind -- Jeff Beck. 55. The Haas Effect. 56. The Advaita jam in the Kolkata hotel room. 57. Here, There and Everywhere -- Geoff Emerick. 58. Paul McCartney listens to John Lennon's Beautiful Boy. 59. Watching the Wheels -- John Lennon. 60. Chris Cornell's covers of Watching the Wheels, Redemption Song, Long As I Can See The Light, Nothing Compares 2 U, I Will Always Love You and Thunder Road. 61. Penny Lane -- The Beatles. 62. Strawberry Fields Forever -- The Beatles. 63. The Bends -- Radiohead. 64. The White Album -- The Beatles. 65. Sticky Fingers, Exile on Main Street and Goat's Head Soup -- The Rolling Stones. 66. Time out of Mind -- Bob Dylan. 67. Amitava Kumar Finds the Breath of Life — Episode 265 of The Seen and the Unseen. 68. A Day in the Life -- The Beatles. 69. Stevie Wonder on YouTube Music, Spotify and Wikipedia. 70. Friends, Crime, & The Cosmos -- Abhishek Upmanyu. 71. This Be The Verse — Philip Larkin. 72. Somebody That I Used To Know -- Mike Dawes. 73. Happy -- Pharrell Williams. 74. Blow by Blow -- Jeff Beck. 75. Cause We've Ended as Lovers -- Jeff Beck. 76. Miles Davis on YouTube Music, Spotify and Wikipedia. 77. Bitches Brew -- MIles Davis. 78. Pat Metheny on YouTube Music, Spotify and Wikipedia. 79. John Scofield on YouTube Music, Spotify and Wikipedia. 80. I Can See Your House from Here -- Pat Metheny and John Scofield. 81. SD Burman on YouTube Music, Spotify and Wikipedia. 82. John Williams on YouTube Music, Spotify and Wikipedia. 83. The Study of Orchestration -- Samuel Adler. 84. Maurice Ravel on YouTube Music, Spotify and Wikipedia. 85. Claude Debussy on YouTube Music, Spotify and Wikipedia. 86. Johann Sebastian Bach on YouTube Music, Spotify and Wikipedia. 87. Cello Suite No. 1 in G Major -- Johann Sebastian Bach, played by Yo Yo Ma. 88. Thomas Dybdahl on YouTube Music, Spotify and Wikipedia. 89. The Old Man and the Sea -- Ernest Hemingway. 90. The Great Gatsby -- F Scott Fitzgerald. 91. Crime and Punishment — Fyodor Dostoevsky. 92. Atomic Habits — James Clear. 93. Stanley Kubrick on IMDb and Wikipedia. 94. Martin Scorsese on IMDb and Wikipedia. 95. Goodfellas -- Martin Scorsese. 96. Raging Bull -- Martin Scorsese. 97. Bernard Herrmann. 98. Psycho -- Alfred Hitchcock. 99. The Sopranos, Breaking Bad and Better Call Saul. 100. Seven Samurai -- Akira Kurosawa.. 101. The Girl From Kashmir — Episode 295 of The Seen and the Unseen (w Farah Bashir). 102. Dance Dance For the Halva Waala — Episode 294 of The Seen and the Unseen (w Jai Arjun Singh and Subrat Mohanty). 103. Akira Kurosawa and Yasujirō Ozu. 104. Mulholland Drive and Twin Peaks -- David Lynch. 105. Taxi Driver, New York Stories, Casino, Kundun and Silence -- Martin Scorsese. 106. A Whiter Shade of Pale -- Procul Harum. Check out Amit's online course, The Art of Clear Writing. And subscribe to The India Uncut Newsletter. It's free! Episode art: ‘Pieces of Me' by Simahina.

เราเคยเชื่อกันว่า “ความแก่” คือสิ่งที่ทุกคนต้องเผชิญเมื่ออายุมากขึ้น แต่วิทยาศาสตร์ในยุคปัจจุบันเห็นต่าง เพราะมีการค้นพบว่าความแก่นั้นชะลอได้ . ทำความเข้าใจความแก่กันอีกครั้งผ่านทฤษฎีใหม่ ของดอกเตอร์เดวิด ซินแคลร์ จาก Harvard Medical School เจ้าของหนังสือชื่อดัง Lifespan: Why We Age, and Why We Don't Have To พร้อมเคล็ดลับหลากหลายวิธีที่จะช่วยให้เรา “แก่ช้า อายุยืน” . เชิญรับฟังพร้อมๆ กันได้ใน Mission To The Moon EP. นี้ . การหมั่นตรวจสุขภาพก็เป็นอีกหนึ่งวิธีที่ช่วยให้เราดูแลตัวเองได้ตรงจุด รักษาสุขภาพให้แข็งแรงและดูดี แม้จะมีอายุมากขึ้น หากสนใจโปรแกรมตรวจสุขภาพ “All You Can Check” สามารถสอบถามรายละเอียดเพิ่มเติมที่ รพ.พญาไท-เปาโล Call Center โทร. 1772 หรือ Website ของทั้งรพ.พญาไท และ เปาโล ดูรายละเอียดแพ็กเกจได้ที่ลิงก์นี้ : https://bit.ly/3heRQFS . Mission To The Moon x Phayathai & Paolo Hospitals #AllYouCanCheck  #PhyathaiHospital  #PaoloHospital #missiontothemoon #missiontothemoonpodcast

As 2022 draws to a close, it's time to chill. Vikram Sathaye and Roshan Abbas join Amit Varma in episode 309 of The Seen and the Unseen to share wit, wisdom and life lessons that are priceless. There is cricket, there is singing, there are great bad jokes -- never has insight been so much fun! (For full linked show notes, go to SeenUnseen.in.) Also check out: 1. Roshan Abbas at Instagram, Twitter and his own website. 2. Vikram Sathaye at Instagram, Twitter and YouTube. 3. Roshan Abbas and the Creator Economy — Episode 239 of The Seen and the Unseen. 4. Kommune on YouTube, Facebook, Twitter and Instagram. 5. Speechless — Roshan Abbas and Siddharth Banerjee. 6. What the Duck With Vikram Sathaye -- Vikram Sathaye's talk show on YouTube. 7. How Sachin Destroyed My Life -- Vikram Sathaye. 8. Vikram Sathaye's breakout performance at the 2004 Ceat Cricket Awards. 9. Episodes of The Seen and the Unseen on the creator ecosystem with Roshan Abbas, Varun Duggirala, Neelesh Misra, Snehal Pradhan, Chuck Gopal, Nishant Jain, Deepak Shenoy and Abhijit Bhaduri. 10. The Loneliness of the Indian Man -- Episode 303 of The Seen and the Unseen (w Nikhil Taneja). 11. Pu La Deshpande. 12. Roam Research. 13. Zettelkasten on Wikipedia. 14. Dance Dance For the Halva Waala — Episode 294 of The Seen and the Unseen (w Jai Arjun Singh and Subrat Mohanty). 15. Parkinson's Law — C Northcote Parkinson. 16. Bhimsen Joshi on Spotify and YouTube. 17. Arnold: The Education of a Bodybuilder -- Arnold Schwarzenegger. 18. Papa Kehte Hain -- Mahesh Bhatt. 19. Ghar Se Nikalte Hi -- Song from Papa Kehte Hain. 20. Tarkash -- Javed Akhtar. 21. Vijay Tendulkar and Satyadev Dubey. 22. Wednesday, starring Jenna Ortega, directed by Tim Burton & others. 23. 1000 True Fans — Kevin Kelly. 24. 1000 True Fans? Try 100 — Li Jin. 25. The BarberShop with Shantanu. 26. The Refreshing Audacity of Vinay Singhal — Episode 291 of The Seen and the Unseen. 27. Stage.in. 28. Parasite — Bong Joon-ho. 29. Sunandan Lele on Instagram, Twitter, YouTube, LinkedIn and Facebook. 30. Atomic Habits — James Clear. 31. The Love Fools on Instagram, Zomato and Facebook. 32. Behave — Robert Sapolsky. 33. The Double ‘Thank-You' Moment — John Stossel. 34. Seinfeld -- Created by Larry David and Jerry Seinfeld. 35. 3 Deewarein (Nagesh Kukunoor), Satta (Madhur Bhandarkar) and Dil Vil Pyar Vyaar (Anant Mahadevan). 36. A Meditation on Form — Amit Varma. 37. Vijay Gokhale on Amazon. 38. The Evolution of Cricket — Episode 97 of The Seen and the Unseen (w Harsha Bhogle). 39. Profit = Philanthropy — Amit Varma. 40. Nudge -- Richard Thaler and Cass Sunstein. 41. Japan fans clean up the stadium after defeat to Croatia. 42. Euphoria on Hotstar/HBO. 43. Why I'm Hopeful About Twitter -- Amit Varma. 44. Lifespan: Why We Age – and Why We Don't Have To -- David Sinclair. 45. The Lifespan Podcast by David Sinclair. 46. Huberman Lab. 47. Muse: EEG-Powered Meditation & Sleep Headband. 48. Factfulness — Hans Rosling. 49. Genepath Diagnostics. 50. Abby Philips on Twitter, Instagram, YouTube and Google Scholar. 51. The Case Against Sugar — Gary Taubes. 52. The Big Fat Surprise: why butter, meat, and cheese belong in a healthy diet — Nina Teicholz. 53. The Obesity Code — Jason Fung. 54. Why We Sleep — Matthew Walker. 55.The Swimmers -- Sally El Hosaini. 56. Khakee: The Bihar Chapter -- Created by Neeraj Pandey. 57. Bihar Diaries -- Amit Lodha. 58. Angad Daryani of Praan on Twitter, Instagram and LinkedIn. 59. Robert Sapolsky's biology lectures on YouTube. 60. Jonathan Haidt on Amazon, Twitter, Google Scholar and his own website. 61. Anatomy of the Vertical Invader -- IMRB International. 62. Josh Talks and The Lallantop. 63. The full Cristiano Ronaldo Interview With Piers Morgan. 64. Anumita Nadesan on Spotify, YouTube and Instagram. 65. Kusha Kapila on Instagram and YouTube. 66. I Boiled My Buttocks for a Week -- Amit Varma. 67. Propah Lady -- Puma commercial directed by Reema Sengupta. 68. The Life and Times of Mrinal Pande — Episode 263 of The Seen and the Unseen. 69. Glimpses from the event with Zakir Hussain and Sachin Tendulkar. 70. Phineas Gage. 71. Don't think too much of yourself. You're an accident — Amit Varma's column on Chris Cornell's death. 72. Why We Choke — Amit Varma. 73. Garden -- The app for staying in touch. 74. A Creator of the Floating World — Episode 218 of The Seen and the Unseen (w Varun Duggirala). 75. The Artist's Way -- Julia Cameron. 76. Coverage of the Bawraas by YourStory, Times of India and Hindustan Times. 77. Varun Grover Is in the House — Episode 292 of The Seen and the Unseen. 78. Monsoon Wedding -- Mira Nair. 79. How to Be Successful -- Sam Altman. Check out Amit's online course, The Art of Clear Writing. And subscribe to The India Uncut Newsletter. It's free! Episode art: ‘Time For Adda' by Simahina.

Right, swimming! It's probably the discipline that frustrates triathletes most. It takes years of regular pool time to make even small gains. There is so much noise out there that choosing the right path for yourself is a big task. I'm fortunate to be at the front end of the triathlon swim, but everyone needs help which is why I turned to this week's guest, swim coach Josh Spencer, to help me understand why my shoulder was hurting after each swim. Josh highlighted some technical flaws and gave me some drills to help correct the problem. On chatting with Josh it turns out that we're pretty aligned in our approach to helping swimmers improve, and I really wanted to share some of his knowledge with you in this episode. There are many topics covered, including some you might find contrary to popular belief: There are only two ways to get faster in the pool Why swimming backstroke will improve your freestyle If you want to be a better swimmer you might need to up your mobility, not your volume The polarised approach to fitness works really well for swimming Sometimes you have to forget about the clock Even a 5-minute pre-swim warm-up can make a big difference to your pool session The YES or NO round - Josh's thoughts on popular swim tools Josh doesn't do social media but if you would like to contact him about swim coaching then please email him. We talked about the swim stroke of Alexander Popov. Please watch this video, there are some really good technical points from 13 minutes onwards. This is a great video. Probably the best ever men's 200m freestyle race (Athens Olympics 2004) - Thorpe v Van de Hoogenband v Phelps. Just watch the underwater footage of the catch. Almost perfect!!   Josh also recommends the following books: The Rise of the Ultra Runners: A Journey to the Edge of Human Endurance by Adharanand Finn Lifespan: Why We Age and Why We Don't Have To by David Sinclair To download your FREE 4-week mobility plan, please click here. Join our SWAT/High Performance Human tribe now, with a happiness guarantee! Join SWAT/High Performance Human tribe here. Purchase a copy of my High Performance Human e-book featuring more than 30 top tips on how to upgrade your life. If you would like to help offset the cost of our podcast production, we would be so grateful.  Please click here to support the HPH podcast.  Thank you! Visit Simon's website for more information about his coaching programmes.  Links to all of Simon's social media channels can be found here.  For any questions please email Beth@TheTriathlonCoach.com.

Question for you: what if you could slow down, stop or even reverse your aging process? What if you could live, not just longer, but better? Extending and even potentially expanding your physical and mental health and well-being. Staving off decline or illness. Is any of that really possible, and what does cutting-edge science have to say?That is what we are talking about with today's guest. David Sinclair. David is a worldwide leader in aging research. He is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School.He's best known for his work on genes and small molecules that delay aging, including the sirtuin genes and resveratrol and its precursors, which we get into. He's published over 170 scientific studies, is the co-inventor on over 50 patents, has co-founded 14 biotechnology companies in the area of aging vaccines, diabetes, fertility Cancer Biodefense. His book Lifespan, Why We Age, and Why We Don't Have To explores what we get wrong about aging and how to approach it differently. And, his podcast, Lifespan, explores healthy aging and how to live not just longer, but better, too. So excited to share this Best Of conversation with you.You can find David at: Website | InstagramIf you LOVED this episode you'll also love the conversations we had with Aviva Romm, MD about how hormones control health, and what we can do about it.Check out our offerings & partners: My New Book SparkedMy New Podcast SPARKEDVisit Our Sponsor Page For a Complete List of Vanity URLs & Discount Codes.Peloton: Access high-energy workouts, instantly. Discover Peloton: streaming fitness classes to you live and on-demand. Try Peloton risk-free with a 30 Day Home Trial. New Members only. Not available in remote locations. See additional terms at www.onepeloton.com/home-trial. Hosted on Acast. See acast.com/privacy for more information.

Oxygen therapy to lengthen our telomeres and prolong the life of our chromosomes. Boosting the functioning of our mitochondria with NAD. Stem cell rejuvenation. These are just some of the exciting therapies that scientists are exploring in their quest to prevent the decline and suffering we experience as we age. But some scientists argue that these are just partial fixes and that the answer to the eternal quest for the fountain of youth lies in pinpointing the upstream driver of these hallmarks of ageing. They claim that thanks to breakthroughs in the science of genetics they have finally discovered the control system that generates the strength and health we associate with youth. It's the “epigenome”, which is the packaging that coils around our DNA and switches on and off the genes that shape the identity of our cells. They say that as we age this packaging unravels, which deregulates the DNA and cell information they have been safeguarding. Fix the packaging and we can completely reset our DNA and cells and regenerate our bodies so they are once again like brand new. Skeptics say that we need to look no farther than evolution to recognize that while ageing can be slowed down it can't be abolished. Despite the formidable powers of natural selection, a species that doesn't age and die has not emerged. This is because ageing is marked not just by cells that are slowing down but also by cells that are rapidly multiplying and becoming cancerous. It is impossible to fix one without the other benefiting, a form of intercell competition where human beings and our hopes of eradicating old age are the losers. Arguing for the motion is David Sinclair, Professor of Genetics at Harvard Medical School and one of TIME Magazine's “Top 50 people in health care”. He is the author of over 200 scientific papers as well as the New York Times bestseller Lifespan: Why We Age—and Why We Don't Have To. Arguing against the motion is Joanna Masel, Professor of Ecology & Evolutionary Biology at the University of Arizona. She is a mathematical modeller who has published over 50 papers in a variety of scientific fields and is the author of Bypass Wall Street: A Biologist's Guide to the Rat Race. Sources: ZNews, Fox News, WKTV Newschannel2, Science Time The host of the Munk Debates is Rudyard Griffiths - @rudyardg.   Tweet your comments about this episode to @munkdebate or comment on our Facebook page https://www.facebook.com/munkdebates/ To sign up for a weekly email reminder for this podcast, send an email to podcast@munkdebates.com.   To support civil and substantive debate on the big questions of the day, consider becoming a Munk Member at https://munkdebates.com/membership Members receive access to our 10+ year library of great debates in HD video, a free Munk Debates book, newsletter and ticketing privileges at our live events. This podcast is a project of the Munk Debates, a Canadian charitable organization dedicated to fostering civil and substantive public dialogue - https://munkdebates.com/ The Munk Debates podcast is produced by Antica, Canada's largest private audio production company - https://www.anticaproductions.com/   Executive Producer: Stuart Coxe, CEO Antica Productions Senior Producer: Christina Campbell Editor: Kieran Lynch Producer: Nicole Edwards Associate Producer: Abhi Raheja

Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it's never too late to slow the process of aging, and so much more.   Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He's been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To. -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

I'm excited to introduce this week's guest, Dr. Molly Maloof, who has been at the forefront of how biohacking, functional medicine, and personalized healthcare can be used to optimize your health.  Dr. Molly provides personalized medicine to world class entrepreneurs, investors, and technology executives in Silicon Valley. She has also worked as an advisor or consultant to over 50 companies in the digital health, consumer health, and biotech industries, and she's currently writing a book on biohacking for women. Dr. Molly gives so much incredible information on this episode that you can start implementing today. To make it a little bit easier, I created this free downloadable “Optimize Your Health Checklist” that lists out Dr. Molly's recommended steps for achieving optimal health. On Ep. 176, we cover: Dr. Molly's background: Her path away from “traditional” medicine to create her own lane Biohacking 101: How to start optimizing your health (with lots of actionable specifics!) Why women and men need to take different approaches to biohacking Testing you should be doing, supplements you need to take, and more specific recommendations from Dr. Molly.  Her new venture as the founder and CEO of Adamo Bioscience, a company pioneering the science of love The biggest driver of long term happiness and health, and more! **Please note that this is for informational purposes only, and is not intended to be taken as medical advice. Free Resource! Get my 3 favorite FREE self-compassion guided meditations for entrepreneurs from Dr. Kristin Neff here: https://www.brittanykrystle.com/optimize Dr. Molly's Book Recommendations Power vs. Force: The Hidden Determinants of Human Behavior by David R. Hawkins, M.D., PhD https://amzn.to/3ELNptc Real Magic: Ancient Wisdom, Modern Science, and a Guide to the Secret Power of the Universe by Dean Radin, PhD https://amzn.to/39eXrHJ The Mood Cure: The 4-Step Program to Take Charge of Your Emotions--Today by Julia Ross, M.A. https://amzn.to/3vDQCae The Anatomy of Anxiety by Ellen Vora, M.D. https://amzn.to/3Msxjri   My Book Recommendations Glucose Revolution: The Life-Changing Power of Balancing Your Blood Sugar by Jessie Inchauspé https://amzn.to/3keU05V State Change: End Anxiety, Beat Burnout, and Ignite a New Baseline of Energy and Flow by Robin Berzin, MD https://amzn.to/3LBmseF Lifespan: Why We Age—and Why We Don't Have To by David A. Sinclair, PhD, AO, and Matthew LaPlante https://amzn.to/3vhyrIs Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love by Tony Robbins, Peter H. Diamandis, MD, and Robert Hariri, MD, PhD https://amzn.to/3keGNKm   Recommended Products and Suppplements Oura ring https://ouraring.com/ Garmin vivosmart 4 https://amzn.to/3kdgPXJ  Upgraded Formulas - mineral and metal testing https://bit.ly/37HT1sB Levels Health - App-Based Continuous Glucose Monitor https://www.levelshealth.com/join?partner=DRMOLLY&campaignid=36303 Genova Diagnostics - allergy testing (food, molds, airborne) https://www.gdx.net/product/igg-food-antibodies-food-sensitivity-test-blood  Parsley Health (affordable functional medicine doctors) https://www.parsleyhealth.com/ Qualia Skin Science-Backed Radiance -  https://amzn.to/3ka43cF Zembrin - natural mood booster https://amzn.to/3EWIqpF Omega Supplement:Thorne Super EPA https://amzn.to/3Mw7oPf Vitamin D3 and K2 Liquid Supplement https://amzn.to/3KiKmK8 KAL B-12 Methylcobalamin Active Melt Raspberry Tablets https://amzn.to/3vkVyC3 Some reputable supplement brands:Quicksilver Scientific (https://amzn.to/392ksNS),Thorne (https://amzn.to/3k6XxDC),Metagenics (https://amzn.to/3MoD8Wz)  Want to Support the Podcast for free? Leaving a rating goes a long way and allows me to continue putting out quality content! You can leave one on Apple (https://podcasts.apple.com/us/podcast/beyond-influential/id1264581842) or Spotify (https://open.spotify.com/show/0Z55W0OeqRN9VHhVVDQaMD)! Take a screenshot while listening to the episode and share it in your Instagram Stories—and make sure to tag me @brittanykrystle!   To connect with Dr. Molly: Website: https://drmolly.co/ Facebook: https://www.facebook.com/MollyMaloofMD/   Twitter: https://twitter.com/mollymaloofmd   Instagram: https://www.instagram.com/drmolly.co/   To connect with me, Brittany Krystle: Website: https://www.brittanykrystle.com/ Instagram: https://www.instagram.com/brittanykrystle/ Twitter: https://www.twitter.com/brittanykrystle/   LinkedIn: https://www.linkedin.com/in/brittanykrystle/   Facebook: https://www.facebook.com/brittanykrystlexoxo/   Pinterest: https://www.pinterest.com/brittanykrystle/   YouTube: https://www.youtube.com/channel/UC1f0uI6wzWqp58n7fk-7-1g     Don't want to miss an episode (or valuable free resources!)? Get on my list here: https://www.brittanykrystle.com/subscribe   *Disclosure: These show notes may contain affiliate links. If you choose to purchase through them, I may earn a commission which helps me continue to create this content (at no extra cost to you). Thank you so much for your support.

What makes a food a comfort food? Do those foods really comfort you? This episode begins by discussing why we crave our favorite comfort foods and what, if anything, does eating those foods do for us. https://www.theatlantic.com/health/archive/2015/04/why-comfort-food-comforts/389613/  Can you really slow down the aging process and add years to your life? There is a lot of hype about products that supposedly help you turn back the clock that don't have much evidence to support the claims. However, there is also a lot of serious research into increasing lifespan by slowing the effects of getting older. One of the people on front lines of this is Dr. David Sinclair who is a leading longevity expert, professor at Harvard University and author of the book Lifespan: Why we Age and Why We Don't Have To (https://amzn.to/3KXpzN8). Listen as he explains proven ways that he says can easily add 14 years to your life - or more. Is a day really 24 hours long? Do we really have just 5 senses? Is it lack of gravity that allows astronauts on the International Space Station to float around? These are examples of things many people believe to be true that really aren't - or may just have a grain or two of truth according to my guest Philip Bouchard. He is a software engineer, educator and author of the book The Stickler's Guide to Science in the Age of Misinformation: The Real Science Behind Hacky Headlines, Crappy Clickbait, and Suspect Sources (https://amzn.to/3tH5swJ).  Why does your stomach growl? People often think it is because you are hungry and your stomach is empty. Listen as I explain what is really going on and why it isn't actually your stomach that is doing the growling. https://www.medicalnewstoday.com/articles/319901 PLEASE SUPPORT OUR SPONSORS! We really like The Jordan Harbinger Show! Check out https://jordanharbinger.com/start OR search for it on Apple Podcasts, Spotify or wherever you listen!  Go to https://Indeed.com/Something to claim your $75 credit before March 31st! Discover matches all the cash back you've earned at the end of your first year! Learn more at https://discover.com/match Follow CALL ME CURIOUS on Apple Podcasts, Amazon Music, or you can listen one week early and ad-free by joining Wondery Plus in the Wondery app.  Download Best Fiends FREE today on the App Store or Google Play! Use SheetzGo on the Sheetz app! Just open the app, scan your snacks, tap your payment method and go!  https://www.geico.com Bundle your policies and save! It's Geico easy! Learn more about your ad choices. Visit megaphone.fm/adchoices

A future in which we can pop pills to make us look and physically morph into being ten years younger… Well, according to biologist and Professor of Genetics, David Sinclair, it might not be as far-fetched as it sounds. In this episode of Brilliant Brains, Tim Samuels speaks to Dr David Sinclair about his groundbreaking book Lifespan: Why We Age - and Why We Don't Have To, why we need to view ageing as an illness, the implications of people routinely living into their 120s, and his daily regime for keeping ageing at bay.Brilliant Brains is a deep, deep - no holds - dive into the minds of some of the most fascinating thinkers out there.Find all the shows at karmacist.com/podcast. Music by Natureboy - remixed by Mudd. Hosted on Acast. See acast.com/privacy for more information.

InsideTracker is a truly personalized nutrition and performance system that can help you feel better, live longer, and maybe even figure out how to turn back the clock. Their mission is to help people add years to their lives and life to their years by optimizing their bodies from the inside out. By analyzing your body's data, they can give you a crystal clear picture of what's going on inside you along with a science-backed action plan for improving your health and becoming your best self. Before I found this system, I was searching for a way to know more about my current health. I also wanted to know how I could feel better, live a longer, healthier life, and be in my most optimal state of wellness. In this episode I share my personal experience using InsideTracker as a guide to better wellness, with an added perk: I'm getting younger too! Stay tuned for a coupon code to try InsideTracker for yourself this year! Check out InsideTracker.com and listen to the InsideTracker podcast, Longevity by Design with InsideTracker founder Dr. Gil Blander as well. In this episode I also mention Dr. David Sinclair and his book, Lifespan: Why We Age and Why We Don't Have To. Dr. Sinclair is one of the many scientists on InsideTracker's scientific advisory board. Just another reason why I'm impressed with what they do. Stay tuned for the special coupon code for 20% off your first order of any InsideTracker plan. --- Support this podcast: https://anchor.fm/plantfull/support

Was hat es mit dem Altern auf sich und wie lässt sich der Alterungsprozess verlangsamen?  Im hohen Alter noch voller Energie bleiben ist tatsächlich etwas, das man kontrollieren kann.  Im heutigen Podcast gebe ich dir einige interessante Einblicke aus dem Buch "Lifespan: Why We Age – and Why We Don't Have To" von David Sinclair Wie ist deine Meinung dazu?  Schreibe mir gerne auf Instagram: https://www.instagram.com/denizdeke/ https://www.instagram.com/erschaffedichneu/ 

In this episode, I talk to world-renowned biologist David Sinclair about aging and longevity. David rejects the notion that the deterioration of health is a natural part of growing old and asserts that aging is a disease itself that we need to reverse. But how will a reset of our biological clocks affect our interactions, responses to adversity, morality, and how we live our lives? We discuss the ethical implications of limitless lifespans and also touch on the topics of death, evolution, genetics, medicine, and data tracking.BioDr. David Sinclair is a professor in the department of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and co-founder of the scientific journal Aging. He is best known for his work on understanding why we age and how to slow its effects. In addition to being a co-founder of several biotechnology companies, he's the author of the book Lifespan: Why We Age – and Why We Don't Have To. Dr. Sinclair was listed by TIME magazine as one of the “100 most influential people in the world”.Website: sinclair.hms.harvard.eduTwitter: @davidasinclair Topics00:02:26 David's “sticky beak” personality00:05:08 David's childhood and upbringing00:10:21 The torment of inevitable death 00:15:13 David's life purpose00:22:06 Intergenerational interactions 00:28:59 Aging is a disease we can reverse 00:32:20 Accelerating human evolution 00:36:24 The SIR2 gene and the NMN+ pill00:40:04 Reverse brain aging and Alzheimer's00:42:50 Gene therapy in pills00:48:45 Will we be happier with longer lifespans? 00:52:49 Inside Tracker00:55:31 The future of data tracking and medicine01:00:47 The Information Theory of Aging01:09:08 Is there a biological limit to our lifespans?01:14:21 Mental states can produce epigenetic changes01:20:39 David's future projects

As the saying goes, trust your gut — and this isn't only figuratively. One of the most overlooked aspects of health is our digestive system. We tend to ignore and underestimate the symptoms we experience around our gut. But with its link to our brains, our guts play a much more significant role in our overall health. The simple act of eating healthy foods can completely turn your life around. Kirsty Wirth joins us in this episode to share how reexamining gut health impacted her and her son's life. She talks about the road to recovery, specifically her family undergoing fecal microbial transplant (FMT). Kirsty highlights the importance of in-depth gut health testing, cutting out junk foods, and consuming healthy foods. She further discusses the two types of fermented food and how we can incorporate it into our diet. If you're having trouble with your digestive system and want to know which healthy foods to choose, this episode is for you.    Here are three reasons why you should listen to the full episode: Learn how an undiagnosed gut issue can lead to an autism spectrum misdiagnosis. Discover the importance of eating healthy foods when looking after your microbiome. Find out the two types of fermented food and their effects on the body.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new program, BOOSTCAMP, is coming this September at Peak Wellness!  Listen to my other Pushing the Limits episodes:  #170: The Search for the Perfect Protein and Why So Many of Us Are Deficient with Dr David Minkoff #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Kirsty: Instagram I Facebook I Email  Kultured Wellness Get your Kultured Wellness starter culture here! Join a Kultured Wellness Programme today! Kulturing Kuriosity podcast Lifespan: Why We Age – and Why We Don't Have To by Dr David Sinclair   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third-party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [04:55] The Story Behind Kultured Wellness Kirsty started Kultured Wellness because of her personal experience and what her son went through.  She started having tummy upsets from age two onwards. She would constantly swing between constipation and diarrhea.  Acquiring viral encephalitis at age 13 and being hospitalised for a week was a landmark time in Kirsty's life. Gut problems became a constant issue from then on. Her husband, who is a nurse, told her constant diarrhea is not normal. So, she dabbled with various diets but didn't stick with them. It's not until they found out about her son's conditions that Kirsty took concrete action. [09:55] Kirsty's Son's Autism Spectrum Diagnosis At 13 months, Noah suffered from infections and tummy troubles. Fortunately, his recovery progressed well. But at 18 months, Noah became completely non-verbal, underwent behavioural changes, and suffered from constant diarrhea. The paediatrician said that Noah's condition was normal. However, his condition only worsened.  Then, Noah was diagnosed with autism. This gave them funding for treatment and support. [13:56] Discovery of an Underlying Gut Issue The possibility that Kirsty passed on her diarrhea issue to Noah was always at the back of her mind. They found a doctor who listened to their suspicion that Noah has an underlying condition.  After testing Noah's stool sample, they discovered that he had Clostridium difficile, a type of antibiotic-resistant bacteria. This bacteria releases endotoxin that compromises the gut and the blood-brain barrier. They found that the endotoxin in Noah's body had attached to the brain receptors responsible for socialisation and learning. [17:21] Undergoing Fecal Microbial Transplant (FMT) Kirsty and her two children participated in a research study in Canada. There, they underwent a fecal microbial transplant. Their guts were flushed with antibiotics to get rid of everything, including the Clostridium difficile. These were then replaced with donors' microbes.  Kirsty's children were the youngest people to undergo FMT. While they were there, Noah started becoming more sociable. Not everyone needs to undergo FMT to recover their gut. There are now many ways to modulate the gut, one of which is eating healthy foods. Tune in to the full episode to hear more about Noah's recovery and development as a teen! [25:42] Getting Diagnosed with PANDAS PANDAS is an autoimmune neurological condition associated with an antigen. Both Kirsty and Noah got diagnosed with it. It stands for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. Listen to the full podcast to learn more about PANDAS and how Kirsty acquired it! [33:13] Looking After Your Microbiome Test, don't guess. Get a comprehensive stool analysis. Kirsty uses two tests for her clients. You need to be intentional in choosing healthy foods. Include fermented and nourishing food for your gut. Also, remember that diets do not work. No amount of willpower can go against our primal built-in set point. [46:10] Two Types of Fermented Food and Their Effect on the Body The first is the wild type. This includes histamine-forming foods or lactate-forming metabolites. Our gut has microbes that consume histamine and help us not develop histamine issues. The second is uncultured ferment. These are specific ferments in a controlled environment with specifically chosen strains. People struggling with lactate-forming metabolites should choose D-lactate bacteria strains.  These strains break down and down-regulate histamines without causing reactions. [48:50] Incorporating Fermented Healthy Foods into Your Diet You can start with small amounts of uncultured ferment to build out your microbiome.  Then, you can start dabbling with wild ferments. Kirsty develops cultures with nine different strains that have efficacy for autoimmune, neurological, and digestive conditions. Kultured Wellness offers a starter culture that you make yourself. Listen to the full episode to know the ingredients and the procedure! [53:05] On Probiotics and Digestive Enzymes One capsule of probiotics in the market has around 3 million CFU or colony-forming units.  Meanwhile, a cup of Kultured Wellness yoghurt has 41 billion CFU. The absence of digestive enzymes and stomach acid is a major problem today. Fermented food helps with this problem because it has already been pre-digested from the fermenting process.  Fermented food doesn't require a robust amount of digestive enzymes. In fact, it supports the excretion of stomach acid. [57:06] Parting Advice  Be curious and try your best to connect with your body. You're in a state of fight or flight all the time when you're unwell. We should not be focusing on DNA; it's the microbes that affect our DNA. Being curious, taking responsibility, owning it, and wanting more for yourself is crucial.   7 Powerful Quotes ‘I have seen how important your gut is and how it can completely change the pathway of your life. It can completely change who you are as a person.' ‘You don't just suddenly wake up one day and you've got cognition issues; that's coming from somewhere.' ‘So the first thing is just test, don't guess... We [can] really find out what is happening in our gut, and we can find out what it is doing to the rest of our body.' ‘If you want to make change, you've got to front up to make the change.' ‘If they don't include fermented foods and they don't include nourishing foods for their gut, they're relying on willpower. No one can get anywhere with willpower.' ‘It's what everyone finds hard and doesn't know, is that you should never rely on willpower. Diets will never work.' ‘DNA is not what we should be focusing on. It's actually the microbes and those fungi and viruses that make up our whole body that actually interacts through that.'   About Kirsty Kirsty Wirth is the founder of Kultured Wellness and an expert in cultures, gut health, and probiotics. Kultured Wellness is a company dedicated to providing knowledge and healthy foods for optimum gut health. As an integrative health coach, Kirsty's area of interest is in how lifestyle, environment, and diet can impact gut health and the immune system. Drawing on her background and years of research, Kirsty educates people on the root cause behind underlying conditions. Her mission is to spread the word about the benefits of healthy foods, particularly fermented food in nourishing the gut's microbiome. If you want to learn more about Kultured Wellness, you may visit their website. You can reach out to Kirsty on Instagram and Facebook. You can also send her an email at mailto:info@kulturedwellness.com.     Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can be inspired to eat healthy foods for their gut health.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

The most successful people are also the most purposeful. They create a vision for the future and take steps to get a little better every day. They take the time to ask: Is my life working for me? If not, how would I like it to look different? David Osborn is the principal owner of the sixth largest real estate company in the US with 4,500-plus agents and $11B in annual sales. David also runs a real estate investing private equity firm and operates 35 other profitable real estate related businesses in the US and Canada. He is well-known for being one of the cofounders of GoBundance, a community of healthy, wealthy, generous men who choose to lead EPIC lives. On this episode of Financial Freedom with Real Estate Investing, David joins cohost Garrett Lynch and me to explain his tagline, ‘Who you become on your journey is far more important than what you achieve.' He offers insight on the value of connecting with the right people and growing into the best version of yourself. Listen in to understand why David's definition of wealth involves more than just money and find out how the most successful people get clear on where they're going and walk in purpose. Key Takeaways  How David became a real estate investor Got start as agent, opened KW franchises in TX, NM All-in on investing in 2011 but ran out of own capital Mission to meet wealthy people and raise money Establish fund to invest in single family rentals What investments David is bullish on right now Dwelling spaces and rentals (single and multifamily) Real estate in Sunbelt states with fewer regulations Why who you become is more important than what you achieve Controlling every decision makes you the bottleneck Leadership means delegating trust (world gets bigger) External world = reflection of who you are as human The areas of his life David is working on right now More present with wife and children Working with coach on conscious leadership Meditate on regular basis Health including workouts Learning (40 books/year and podcasts) How David thinks about finding work-life balance Worked 12-hour days to achieve financial freedom Work smarter now, better relationships at home David's well-rounded definition of wealth More than just money and financial freedom Being good human, finding ways to contribute Having adventures and being well-learned Why it's crucial to surround yourself with the right people Genius of humans = sharing and connectivity Find peers who push and inspire you to get better The GoBundance origin story Accountability partners with Pat Hiban, Tim Rhode Invite others to join in bucket-list adventures Growth comes from authenticity and transparency David's top lessons learned as an entrepreneur Know where you're going (purposeful vision for life) Invest in marriage and make time for kids Connect with David Osborn David's Website David on Instagram GoBundance Resources Be a Part of Michael's Deal Maker Mastermind Join the Nighthawk Equity Investor Club Entrepreneurs' Organization TIGER 21 Conscious Loving: The Journey to Co-Commitment by Gay & Kathlyn Hendricks The 15 Commitments of Conscious Leadership: A New Paradigm for Sustainable Success by Jim Dethmer, Diana Chapman & Kaley Klemp The Almanack of Naval Ravikant: A Guide to Wealth and Happiness by Eric Jorgenson Huberman Lab Podcast Wealth Can't Wait: Avoid the 7 Wealth Traps, Implement the 7 Business Pillars, and Complete a Life Audit Today! by David Osborn & Paul Morris Diego Corzo The Family Board Meeting: You Have 18 Summers to Create Lasting Connection with Your Children by Jim Sheils Lifespan: Why We Age—and Why We Don't Have To by David A. Sinclair Black Belt of the Mind by Fred Grosse Pat Hiban Tim Rhode Scott Harrison of Charity Water Gary Keller The Miracle Morning: The Not-So-Obvious Secret Guaranteed to Transform Your Life (Before 8AM) by Hal Elrod Richard Branson Tribe of Millionaires: What If One Choice Could Change Everything? by David Osborn & Pat Hiban Michael's Website  Michael on Facebook  Michael on Instagram  Michael on YouTube  Apartment Investor Network Facebook Group Podcast Show Notes

David Sinclair (biologist, Professor of Genetics at Harvard Medical School, and author of Lifespan: Why We Age and Why We Don't Have To) discusses ways we can extend our lifespan and the work he's doing to slow and reverse aging brain cells. He details the best lifestyle changes and emerging technologies available now to prevent most diseases until our 80's, increase longevity, and even reverse the effects of aging. David opens up about his mental health struggles stemming from his own insecurities and frustrations with the planet, how his mother's passing changed his outlook on life, and the dream he had that influenced his research and became a turning point in his career. After debating about intermittent fasting, Mayim and David examine the thread between solving problems in medicine, economics, and sociology, the effects of stress on the aging process, and mental health components tied to the aging brain. Mayim considers the amount of resources needed if humans lived longer, and the impact western culture's attitude about aging might have on an increased lifespan.David Sinclair's Book: https://lifespanbook.com/?utm_medium=social&utm_source=linktress&utm_campaign=get%20the%20book

I am delighted to have Dr. Gil Blander, an internationally recognized anti-aging researcher, joining me on the show today! Gil has a background in the basic biology of aging and translating his discoveries into new ways of detecting and preventing age-related conditions. He received a Ph.D. in biology from the Weizmann Institute of Science and completed his postdoctoral fellowship at MIT. He has been featured In CNN Money, The New York Times, Forbes, The Financial Times, and The Boston Globe. There are many connections between Gil's childhood in Israel and his quest for longevity. One of his relatives passed away when he was twelve years old. When that happened, Gil realized that he would not live forever. It worried him, and that concern stimulated his interest in longevity and aging and prompted him to study biology, do a Ph.D. at the Weizmann Institute of Science, spend five years at MIT in the best lab to study aging, and found InsideTracker. Listen in today to find out all you need to know about the lifestyle choices that will promote anti-aging and longevity. IN THIS EPISODE YOU WILL LEARN Gil shares his background. What prompted Gil to leave the lab at MIT to go into the private sector. How and why caloric restriction extends our lifespan. How Gil transitioned from academia into the private sector. Gil explains what happens in the body when calories are restricted. How Gil managed to find the best blood biomarkers for longevity,   performance, and wellness. How Gil found the interventions to optimize anti-aging blood biomarkers. How nutrition and lifestyle changes can aid longevity. How the InsideTracker process works, and why it utilizes blood rather than saliva or urine for the testing. Gill talks about bio-individuality and clarifies some of the confusion often associated with epigenetic testing. Foods that promote or prevent longevity. The lifestyle choices that are essential for anti-aging and longevity. Gil talks about supplements. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia's website  Connect with Gil Blander (InsideTracker) On the website On Facebook, Instagram, LinkedIn,   and Twitter Book mentioned: Lifespan: Why We Age―and Why We Don't Have To  by Dr. David Sinclair

What if I told you that there's a way to keep yourself young? It takes a lot of hard work, and it's a continuing process. However, the payoff is definitely worth it. It also offers a lot of benefits aside from longevity. The secret? It's developing a lifelong passion for learning and growing. In this episode, Craig Harper joins us once again to explain the value of having a growth mindset. We explore how you can keep yourself young and healthy even as you chronologically age. He also emphasises the importance of fun and laughter in our lives. Craig also shares how powerful our minds are and how we can use them to manage our pain.    If you want to know how to develop a growth mindset for a fuller life, then this episode is for you!   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or are wanting to take your performance to the next level and learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third-party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Here are three reasons why you should listen to the full episode: Learn how to develop a growth mindset to keep yourself young and healthy, regardless of your chronological age. Understand why you need to manage your energy and plan fun and laughter into your life. Discover the ways you can change your mindset around pain.    Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Listen to other Pushing the Limits Episodes: #60: Ian Walker - Paraplegic Handbiker - Ultra Distance Athlete #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #188: Awareness and Achieve High Performance with Craig Harper  #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Craig: Website | Instagram | Linkedin Interested to learn more from Craig? You can check out his books and his podcast, The You Project. T: The Story of Testosterone by Carole Hooven  Mind Over Medicine by Lissa Rankin M.D. Lifespan - Why We Age and Why We Don't Have To  by David A. Sinclair PhD Neuroscience professor Andrew Huberman's Instagram  Dr Rhonda Patrick's website A new program, BoostCamp, is coming this September at Peak Wellness!   Episode Highlights [06:50] A Growth Mindset Keeps Us Young and Healthy It's helpful to take advantage of the availability of high-level research and medical journals online. If you're prepared to do the hard work, you can learn anything.  Learning and exposing ourselves to new things are crucial parts of staying young and healthy.  Age is a self-created story.  With a growth mindset, you can change how your body and mind works so that you feel younger than your real age.  [12:23] Develop a Growth Mindset It's vital to surround yourself with people with the same mindset — people who drag you up, not down.  You can also get a similar experience by exposing yourself to good ideas and stories. Be aware of what you're feeding your mind, on top of what you're feeding your body.  School is not a marker of your intelligence. Your academic failures do not matter.  With a growth mindset, you can keep growing and learning.  [17:40] Let Go and Be Happy People tend to have career and exercise plans, but not a fun plan.  We can't be serious all the time — we also need time to have fun and laugh.  Laughter can impact and improve the immune system. Laughing can change the biochemistry of your brain. Plan for the future, but also learn to live in the now. Having a growth mindset is important, but so is finding joy and enjoyment.  [23:31] Look After Your Energy Having fun and resting can impact your energy and emotional system.  These habits can help you work faster than when you're just working all the time.  Remember, volume and quality of work are different.  [30:24] Work-Life Balance Many people believe that they need to balance work and life. However, when you find your passion, it's just life.  Even doing 20 hours of work for a job you hate is worse than 40 hours of doing something you love. There's no one answer for everyone. Everything is a lot more flexible than before. Find what works for you.  [35:56] Change the Way You Think It's unavoidable that we think a certain way because of our upbringing.  Start to become aware of your lack of awareness and your programming.  Learn why you think of things the way you do. Is it because of other people?  Be influenced by other people, but test their ideas through trial and error. Let curiosity fuel your growth mindset.  Listen to the full podcast to learn how Craig learned how to run his gym without a business background!  [44:18] Sharing Academic Knowledge Academics face many restrictions due to the nature and context of their work.  He encourages the academic community to communicate information to everyone, not just to fellow researchers.  He plans to publish a book about his PhD research to share what he knows with the public. Science is constantly changing. We need to keep up with the latest knowledge.   [50:55] Change Your Relationship with Pain There is no simple fix to chronic pain.  The most you can do is change your relationship and perception of pain.  Our minds are powerful enough to create real pain even without any physical injury. Listen to Craig and Lisa's stories about how our minds affect our pain in the full episode!   7 Powerful Quotes from This Episode ‘My mind is the CEO of my life. So I need to make sure that as much as I can, that I'm managing my mind, and my mental energy optimally.' ‘If you're listening to this, and you didn't succeed in the school system, that means absolutely nothing when you're an adult.' ‘We're literally doing our biology good by laughing.' ‘Living is a present tense verb, you can't living in the future, and you can't live in the future.' ‘Often, more is not better. Sometimes more is worse.  So there's a difference between volume of work and output and quality of work.' ‘It's all about those people just taking one step at a time to move forward... That growth mindset that I think is just absolutely crucial.'   About Craig Craig Harper is one of Australia's leading educators, speakers, and writers in health and self-development. He has been an integral part of the Australian health and fitness industry since 1982. In 1990, he established a successful Harper's Personal Training, which evolved into one of the most successful businesses of its kind.  He currently hosts a successful Podcast called 'The You Project'. He is also completing a neuropsychology PhD, studying the spectrum of human thinking and behaviour. Craig speaks on various radio stations around Australia weekly. He currently fills an on-air role as a presenter on a lifestyle show called 'Get a Life', airing on Foxtel.  Want to know more about Craig and his work? Check out his website, or follow him on Instagram and Linkedin!   Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn how to develop a growth mindset. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa   Full Transcript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Well, hi everyone and welcome back to Pushing the Limits with Lisa Tamati. This week I have Craig Harper. He is really well known in Australia. He's a broadcaster, a fitness professional, a PhD scholar, an expert on metacognition, and self-awareness. And we get talking on all those good topics today and also neuro-psycho-immunology, very big word. Really interesting stuff; and we get talking about laughter, we get talking about pain management. We sort of go all over the show in this episode, which I sometimes do on this show. I hope you enjoy this very insightful and deep conversation with Craig Harper.  Before we head over to the show, I just want to let you know that Neil and I at Running Hot Coaching have launched a new program called Boost Camp. Now, this will be starting on the first of September and we're taking registrations now. This is a live eight-week program, where you'll basically boost your life. That's why it's called Boost Camp. not boot camp, Boost Camp. This is all about upgrading your body, learning how to help your body function at its base, learning how your mindset works, and increasing your performance, your health, your well-being and how to energise your mind and your body. In this Boost Camp, we're going to give you the answers you need in a simple, easy-to-follow process using holistic diagnostic tools and looking at the complete picture.  So you're going to go on a personalised health and fitness journey that will have a really life-changing effect on your family and your community. We're going to be talking about things like routine and resilience, mental resilience, which is a big thing that I love to talk about, and how important is in this time of change, in this time of COVID, where everything's upside down, and how we should be all building time and resources around building our resilience and energising our mind and body. We're going to give you a lot of health fundamentals. Because the fundamentals are something simple and easy to do, it means that you probably aren't doing some of the basics right, and we want to help you get there.  We're going to give you the answers you need in a simple, sort of easy, process. So we are now in a position to be able to control and manage all of these stressors and these things that are coming at us all the time, and we want to help you do that in the most optimal manner. So check out what boost camp is all about. Go to www.peakwellness.co.nz/boostcamp. I'll say that again, peakwellness.co.nz/boostcamp, boost with a B-O-O-S-T, boost camp. We hope to see you over there! Right, now over to the show with Craig Harper. Well, hi everyone and welcome to Pushing the Limits! Today, I have someone who is a special treat for you who has been on the show before. He's an absolute legend, and I love him to bits. Craig half and welcome to the show mate, how are you doing?  Craig Harper: Hi Lisa! I'm awesome but you're not.  Lisa: No I'm a bit of a miss, people. I've got shingles, a horrible, horrible virus that I advise nobody to get. Craig: What it— do we know what that's made? What causes it, or is it idiopathic as they say? Lisa: Yeah, no, it is from the chickenpox virus. Although, I've never, ever had that virus. So I'm like heck how, you know, it's related to the cold sore virus and all of that, which I definitely have had often. So it sits on the spinal cord, these little viruses, dormant and then one day when your immune systems are down, it decides to attack and replicate and go hard out. So yeah, that'll be the down for the count now for two and a half weeks. In a lot of pain, but— Craig: What is it like nerve pain or what kind of pain is it?  Lisa: Yes, it's nerve pain. So this one's actually, it hits different nerves in different people, depending on where it decides to pop out. My mum had the femoral nerve, which is one that goes right down from the backbone, quite high up on the backbone, down across the back and then down through the hip flexor and down the leg. I've got all these horrible looking sores, I look like a burn victim all the way down my leg and across my back. And it comes out through the muscles of your like, through the nerves and nerve endings and causes these blisters on top of the skin but it's the nerve pain that's really horrible because there's no comfortable position. There's no easy way to lie or sit and of course, when you're lying at night, it's worse. It's worse at nighttime than in the day. So I learned a lot about shingles. And as usual, we're using these obstacles to be a learning curve. Craig: Why on earth are you doing a bloody podcast? You should be relaxing. Lisa: You're important, you see. I had, you know, I had this appointment with you, and I honour my appointments, and I— Craig: Definitely not important. What's the typical treatment for shingles? Lisa: Well, actually, I wish I'd known this two weeks ago, I didn't know this, but I just had a Zoom call with Dave Asprey, you know, of Bulletproof fame, who is one of my heroes, and he's coming on the show, people, shortly. So that's really exciting. He told me to take something called BHT, butylated hydroxytoluene, which is a synthetic antioxidant. They actually use them in food additives, they said that kills that virus. So I'm like, ‘Right, get me some of that.' But unfortunately, I was already, it's— I only got it just yesterday, because I had to wait for the post. So I'm sort of hoping for a miracle in the next 24 hours.  Also, intravenous vitamin C, I've had three of those on lysine, which also helps. One of the funny things, before we get to the actual topic of the day, is I was taking something called L-Citrulline which helps with nitric oxide production and feeds into the arginine pathway. Apparently, while that's a good thing for most people, the arginine, if you have too much arginine in the body, it can lead to replication of this particular virus, which is really random and I only found that out after the fact. But you know, as a biohacker, who experiments sometimes you get it wrong.  Craig: Sometimes you turn left when you should have turned right.  Lisa: Yes. So that, you know, certainly took a lot of digging in PubMed to find that connection. But I think that's maybe what actually set it off. That combined with a pretty stressful life of like— Craig: It's interesting that you mentioned PubMed because like a lot of people now, you know how people warn people off going Dr Google, you know, whatever, right. But the funny thing is, you can forget Dr Google, I mean, Google's okay. But you can access medical journals, high level— I mean, all of the research journals that I access for my PhD are online. You can literally pretty much access any information you want. We're not talking about anecdotal evidence, and we're not talking about theories and ideas and random kind of junk. We're talking about the highest level research, you literally can find at home now. So if you know how to research and you know what you're looking for, and you can be bothered reading arduous academic papers, you can pretty much learn anything, to any level, if you're prepared to do the work and you know how— and you can be a little bit of a detective, a scientific detective.  Lisa: That is exactly, you know, what I keep saying, and I'm glad you said that because you are a PhD scholar and you are doing this. So you know what you're talking about, and this is exactly what I've done in the last five years, is do deep research and all this sort of stuff. People think that you have to go to university in order to have this education, and that used to be the case. It is no longer the case. We don't have to be actually in medical school to get access to medical texts anymore, which used to be the way. And so we now have the power in our hands to take, to some degree, control over what we're learning and where we're going with this.  It doesn't mean that it's easy. You will know, sifting through PubMed, and all these scholarly Google articles and things in clinical studies is pretty damn confusing sometimes and arduous. But once you get used to that form of learning, you start to be able to sift through relatively fast, and you can really educate yourself. I think having that growth mindset, I mean, you and I never came from an academic background. But thanks to you, I'm actually going to see Prof Schofield next week. Prof Schofield and looking at a PhD, because, I really need to add that to my load. But— Craig: You know, the thing is, I think in general, and I don't know where you're gonna go today, but I think in general, like what one of the things that keeps us young is learning and exposing ourselves, our mind and our emotions and for that matter, our body to new things, whether that's new experiences or new ideas, or new information, or new environments, or new people. This is what floats my boat and it keeps me hungry and it keeps me healthy physically, mentally, emotionally, intellectually, creatively, sociologically. It keeps me healthy. Not only does it keep me in a good place, I'm actually at 57, still getting better. You know, and people might wonder about that sometimes.  Of course, there's an inevitability to chronological aging. Clearly, most people at 80 are not going to be anything like they were at 40. Not that I'm 80. But there's— we know now that there's the unavoidable consistency of time as a construct, as an objective construct. But then there's the way that we behave around and relate to time. Biological aging is not chronological aging. In the middle of the inevitability of time ticking over is, which is an objective thing, there's the subject of human in the middle of it, who can do what he or she wants. So, in other words, a 57-year-old bloke doesn't need to look or feel or function or think like a 57-year-old bloke, right?  When we understand that, in many ways, especially as an experience, age is a self-created story for many people. I mean, you've met, I've met and our listeners have met 45-year-olds that seem 70 and 70-year-olds— and we're not talking about acting young, that's not what we're talking about. I'm not talking about that. I'm not talking about pretending you're not old or acting young. I'm actually talking about changing the way that your body and your mind and your brain and your emotional system works, literally. So that you are literally in terms of function, similar to somebody or a ‘typical' person who's 20 or 25 years younger than you. We didn't even know that this used to be possible, but not only is it possible, if you do certain things, it's very likely that that's the outcome you'll create. Lisa: Yeah, and if you think about our grandparents, and when I think about my Nana at 45 or 50, they were old. When I think about now I'm 52, you're 57, we're going forward, we're actually reaching the peak of our intellectual, well, hopefully not the peak, we're still going up. Physically, we got a few wrinkles and a few grey hairs coming. But even on that front, there is so much what's happening in the longevity space that my take on it is, if I can keep my shit together for the next 10 years, stuff's gonna come online that's gonna help me keep it on for another 20, 30, 40 years.  For me now it's trying to hold my body together as best I can so that when the technology does come, that we are able to meet— and we're accessing some of the stuff now, I mean, I'm taking some of the latest and greatest bloody supplements and biohacking stuff, and actively working towards that, and having this, I think it's a growth mindset. I had Dr Demartini on the show last week, who I love. I think he's an incredible man. His mindset, I mean, he's what nearly, I think he's nearly 70. It looks like he's 40. He's amazing. And his mind is so sharp and so fast it'll leave you and I in the dust. He's processing books every day, like, you know, more than a book a day and thinking his mind through and he's distilling it and he's remembering, and he's retaining it, and he's giving it to the world. This is sort of— you know, he's nothing exceptional. He had learning disabilities, for goodness sake, he had a speech impediment, he couldn't read until he was an adult. In other words, he made that happen. You and I, you know, we both did you know, where you went to university, at least when you're younger, I sort of mucked around on a bicycle for a few years. Travelling the world to see it. But this is the beauty of the time that we live in, and we have access to all this. So that growth mindset, I think keeps you younger, both physically and mentally. Craig: And this is why I reckon it's really important that we hang around with people who drag us up, not down. And that could be you know, this listening to your podcast, of course, like I feel like when I listen to a podcast with somebody like you that shares good ideas and good information and good energy and is a good person, like if I'm walking around, I've literally got my headphones here because I just walked back from the cafe, listening to Joe Rogan's latest podcast with this lady from Harvard talking about testosterone, you'd find it really interesting, wrote a book called T.  When I'm listening to good conversations with good people, I am, one, I'm fascinated and interested, but I'm stimulating myself and my mind in a good way. I'm dragging myself up by exposing myself to good ideas and good thinking, and good stories. Or it might even be just something that's funny, it might— I'm just exposing myself to a couple of dickheads talking about funny shit, right? And I'd spend an hour laughing, which is also therapeutic.  You know, and I think there's that, I think we forget that we're always feeding our mind and our brain something. It's just having more awareness of what am I actually plugging into that amazing thing? Not only just what am I putting in my body, which, of course, is paramount. But what am I putting in, you know, that thing that sits between my ears that literally drives my life? That's my HQ, that's my, my mind is the CEO of my life. So I need to make sure that as much as I can, that I'm managing my mind and my mental energy                                                                                  optimally. Lisa: Yeah. And I think, you know, a lot of people if they didn't do well in the school system, think that, 'Oh, well, I'm not academic therefore I can't learn or continue to learn.' I really encourage people, if you're listening to this, and you didn't succeed in the school system, that means absolutely nothing when you're an adult. The school system has got many flaws, and it didn't cater to everybody. So I just want people to understand that.  You know, just like with Dr Demartini, he taught himself 30 words a day, that's where he started: vocabulary. He taught himself to read and then taught— Albert Einstein was another one, you know, he struggled in school for crying out loud. So school isn't necessarily the marker of whether you're an intelligent human being or not. It's one system and one way of learning that is okay for the average and the masses. But definitely, it leaves a lot of people thinking that they're dumb when they're not dumb.  It's all about those people just taking one step at a time to move forward and becoming, you know, that growth mindset that I think is just absolutely crucial. You talked there about laughter and I wanted to go into that a little bit today too, because I heard you talking on Tiffany, our friend Tiffany's podcast, and you were talking about how important laughter is for the body, for our minds, for our— and if we laugh a lot, we're less likely to fall victim to the whole adult way of being, which is sometimes pretty cynical and miserable. When you think, what is it? Kids laugh something like 70 times a day and adults laugh I think, six times a day or some statistic. Do you want to elaborate on that a little bit? Craig: Well, I used to sit down with you know, I don't do much one-on-one coaching anymore, just because I do other stuff. I would sit with people and go, ‘Alright, tell me about your exercise plan and blah, blah, blah. Tell me about your career plan, blah, blah, blah. Tell me about your financial plan, blah, blah, blah.' Tell me about, you know, whatever. And they have systems and programs and plans for everything.  I would say to them, 'Do you like fun?' And they're like, they look at me like I was a weirdo. 'What do you mean?' I go, 'Well, what do you mean, what do I mean? Like, do you like having fun?' And they're like, very seriously, like, 'Well, of course, everyone likes having fun.' I go, 'Great. What's your fun plan?' And they go, 'What?' I go, 'What's your fun— like, is laughing and having fun important to you?' 'Yeah, yeah.' 'Okay, what's your fun plan?'  They literally, like this idea of just integrating things into my life, which are for no reason other than to laugh and to have fun. Not to be productive and efficient and to tick more boxes and create more income and elevate output and tick fucking boxes and hit KPIs and you know, just to be silly, just to laugh like a dickhead, just to hang out with your mates or your girlfriends, or whatever it is. Just to talk shit, just to, not everything needs to be fucking deep and meaningful and world-changing. Not everything. In fact, it can't, you know?  Our brain and our body and our emotional system and our nervous system and— it can't work like that we can't be elevated all the time. And so, literally when we are laughing, we're changing the biochemistry of our brain. You know, literally when we are having fun, we're impacting our immune system in a real way through that thing I've probably spoken to you about, psychoneuroimmunology, right? We're literally doing our biology good by laughing and there's got to be, for me, there's got to be, because, like you probably, I have a lot of deep and meaningful conversations with people about hard shit. Like, I'm pretty much a specialist at hard conversations. It's what I do. But, you know, and, and I work a lot, and I study a lot. Then there needs to be a valve. You can't be all of that all of the time because you're human, you're not a cyborg, you're not a robot. And this hustle, hustle, hustle, grind, work harder, sleep less, you can, you know, you can sleep when you're dead, it's all bullshit. Because, also, yeah, I want to learn and grow and evolve, and I want to develop new skills. But you know what, I want to also, in the moment, laugh at silly shit. I want to be happy and I want to hang out with people I love and I want to be mentally and emotionally and spiritually nourished.  Like, it's not just about acquiring knowledge and accumulating shit that you're probably not going to use. It's also about the human experience now. This almost sounds contradictory. But because of course, we want a future plan and we want goals and all of those, but we're never going to live in the present because when we get there, it's not the present. It's just another installment of now. So when next Wednesday comes, it's not the future, it's now again, because life is never-ending now, right?  It's like you only like, live— living is a present tense verb. You can't living in the future, and you can't live in the future. You cannot. Yes, I know, this gets a little bit, what's the word existential, but the truth is that, yeah, we need to— well, we don't, we can do whatever we want. But I believe we need to be stimulated so we're learning and growing, and we're doing good stuff for our brain and good stuff for our body. But also that we are giving ourselves a metaphoric hug, and going, 'It's all right to lie on your bed and watch Netflix, as long as it's not 20 hours a day, five days a week,' you know. It's okay to just laugh at silly stuff. It's okay, that there's no purpose to doing this thing other than just joy and enjoyment, you know.  I think that people like you and me who are, maybe we would put ourselves in the kind of driven category, right? You and I are no good at this. Like, at times, having fun and just going, ‘I'm going to do fuck all today.' Because the moment that we do sometimes we start to feel guilty and we start to be like, 'Fuck, I'm not being productive. I've got to be productive.' That, in itself, is a problem for high performance. Like, fuck your high performance, and fuck your productivity today. Be unproductive, be inefficient, and just fucking enjoy it, you know, not— because in a minute, we're going to be dead. We're going to go, 'But fuck, I was productive. But I had no fun, I never laughed, because I was too busy being important.' Fuck all that. Lisa: I think both of us have probably come a long way around finding that out. I mean, I used to love reading fiction novels, and then I went, ‘Oh, I can't be reading fiction novels. I've got so many science books that I have to read.' Here I am, dealing with insomnia at two o'clock in the morning reading texts on nitric oxide, you know. It is this argument that goes on, still in my head if there was an hour where you weren't learning something, you know, I can't. Because I know that if I go for a big drive or something, and I have to travel somewhere, or going for a long run or something, I've probably digested a book on that road trip or three, or 10 podcasts or something and I've actually oh, I get to the end and I'm like, ‘Well, I achieved something.' I've got my little dopamine hits all the way through.  Now I've sort of come to also understand that you need this time out and you need to just have fun. I'm married to this absolute lunatic of a guy called Haisely O'Leary, who I just love, because all day every day, he is just being an idiot. In the best sense of the word. I come out and I'm grumpy and you know, had a hard day and I'm tired, I'm stressed, and I come out and he's doing a little dance, doing some stupid meme or saying some ridiculous thing to me. I'm just like, you know, I crack up at it. That's the best person to have to be around because they keep being—and I'm like, ‘Come on, stop being stupid, you should be doing this and you shouldn't be doing that.' Then I hear myself, and I'm like, ‘No, he's got it right.' Craig: Well, I think he does, in some ways, you know. It's not about all, it's not about one or the other, it's about— and it's recognising that if I look after my energy, and my emotional system, and all of that, I'll get more done in 8 hours than 12 hours when I'm not looking after myself. So more is not better, necessarily. In fact, often, more is not better; sometimes, more is worse. So there's a difference between volume of work and output and quality of work. Also, you know, quality of experience.  I wrote a little thing yesterday, just talking on social media about the fact that I, like all of the things that I do, even study, although it's demanding, but I enjoy it. My job, you know, like, right now you and I do podcasts. I do seven podcasts a week, apart from the ones like this, where I'm being interviewed by someone else, or spoken to by somebody else. My life is somewhat chaotic, but I don't really, in terms of having a ‘job'. Well, one, I don't have a job. I haven't had a job since I was 26. Two, I don't really feel a sense of work, like most people do.  Like the other night, I did a gig. I don't know if you, if I posted a little thing about this on Insta, and I was doing a talk for Hewlett Packard in Spain. Now, how cool is the world? Right? So I'm talking here, right here in my house, you can see, obviously, your listeners can't. But this is not video, is it? Just us? I wish I knew that earlier. Sorry, everyone, I would have brushed my hair. But anyway, you should see my hair by the way. I look like bloody Doc from Back to the Future. Anyway, but I'm sitting in here, I'm sitting in the studio, and I'm about to talk to a few hundred people in Spain, right, which is where, that's where they're all— that's where I was dealing with the people who are organising me to speak.  Just before I'm about to go live at 5:30, the lady who had organised me was texting me. So it's on Zoom. There's already a guy on the screen speaking and then lots of little squares of other humans. I said to her, ‘How many?' and said, ‘You know, like a few 100.' I said, ‘Cool.' I go, ‘Everyone's in Spain,' and she goes, ‘No, no, we're in Spain, but the audience is around the world.' And I go, ‘Really? How many countries?' She goes, ‘38.' I'm sitting here and I'm thinking, I'm wearing a black t-shirt. I'm wearing my camo shorts. I've got bare feet. I'm talking to hundreds of humans from this big organisation in 38 countries, and I'm talking about the stuff that I am passionate about, right? I don't have to do any prep, because it's my default setting. I'm just talking. I had to talk for an hour and a half about high performance. Well, giddy up, that's like an hour and a half of breathing. You know?  I just had such fun, and I had this moment, Lisa, halfway through, I don't know, but about halfway through, where I'm like, I remember growing up in a paradigm where pretty much when I was a kid everyone went and got a job and you went, you became a cop or you sold clothes, or you're a bricky or sparky or you're some kind of tradie. A few of my super smart friends went to university. That was way over my head, I'm like, ‘Fuck university.' But there was literally about 50 jobs in the world. You know, it's like there was only 50 jobs, and everyone or nearly everyone fitted into one of those 50. There was a few other ones but for the most part, nearly everyone fitted into about 50 jobs. I'm sitting there going— I won't say what but I'm earning pretty good money. I'm sitting in bare feet in my house talking to humans around the world about this stuff that I want to tell everyone about anyway.  I do it for free on my podcast and your podcast and I do it anyway. I have this great time, it's a really good experience. Then I finish at 7 pm. Then I walk 15 feet into the kitchen and put the kettle on and check my messages.  Lisa: No commuting, no travelling, no flying. Craig: I'm like, ‘How is this a job?' I'm like, ‘How is this real?' ‘This is a scam. I'm scamming everybody.' Like, how great is 2021? I know there's a lot of shit going on and I'm not trying to be insensitive, and it's smashed my business too. All of my live events for 2020 got kicked in the dick in two weeks, right? I got financially annihilated, but you just go, ‘Oh well, improvise, adapt, overcome and figure shit out.' But, I think when you can have it and a lot of people and it's a very well-worn kind of idea. But when you're, what you love, and what you're curious about, and how you make a few bucks, when that can all collide, then life is a different thing. Then there's not work and life, there's just life.  You know, and so when we talk about this idea of work-life balance, you know, it's like the old days that talk about that a lot. And it's like, almost like there was some seesaw, some metaphoric seesaw with work on one side and life on the other. And when you get balance like that— because what happens, think about this, if we're just basing it on numbers, like all 40 hours of work versus however many hours of non-work or however many hours of recreation and recovery. But if you're doing even 20 hours of a job that you hate, that's going to fuck you up. That's gonna, that's gonna mess with you physically, mentally, and emotionally. That's going to be toxic; that's going to be damaging; that's going to be soul-destroying, versus something else like me studying 40 hours a week, working 40, 50 hours a week doing 90 in total, depending on the week and loving it, and loving it. And going, ‘I feel better than I've ever felt in my life.'  I still train every day, and I still, I live 600-800 metres from the beach, I still walk to the beach every day, you know. And I still hang out with my friends. You know, it's like, it doesn't have to be this cookie-cutter approach. The beauty I think of life, with your food, with your lifestyle, with your career, with your relationships with the way that you learn, like the way that you do business, everything now is so much more flexible, and optional than any time ever before that we can literally create our own blueprint for living. Lisa: Yeah. And then it's not always easy. And sometimes it takes time to get momentum and stuff. Being, both you and I have both said before we're unemployable. Like, I'm definitely not someone you want to employ, because I'm just always going to run my own ship. I've always been like that, and that's the entrepreneurial personality. So not everyone is set up for that personality-wise. So you know, we're a certain type of people that likes to run in a certain type of way. And we need lots of other people when doing the other paths.  There is this ability now to start to change the way you think about things. And this is really important for people who are unhappy in where they're at right now. To think, ‘Hang on a minute. I've been I don't know, policeman, teacher, whatever you've been, I don't want to be there anymore. Is there another me out there? Is there a different future that I can hit?' The answer is yes, if you're prepared to put in the work, and the time, and the effort, the looking at understanding and learning, the change, being adaptable, the risk-taking, all of those aspects of it. Yes, but there is ways now that you can do that where they weren't 30 years ago, when I came out of school I couldn't be, I was going to be an accountant. Can you imagine anything worse than that?  Craig: Hi, hi. Shout out to all our account listeners, we love you and we need you. Lisa: I wasn't that— Academically that's I was good at it. But geez, I hated it. And I did it because of parental pushing direction. Thank goodness, I sort of wake up to that. And you know, after three years. I had Mark Commander Mark Devine on the show. He's a Navy SEAL, man. You have to have him on the show. I'll hook you up. He's just a buck. He became an accountant before he became a Navy SEAL and now he's got the best of both worlds really, you know, but like you couldn't get more non-accountant than Mark Devine. We all go into the things when we leave school that we think we're meant to be doing. And they're not necessarily— and I think you know, the most interesting 50 year-olds still don't know what the hell they want to be when they grow up. Just interrupting the program briefly to let you know that we have a new Patron program for the podcast. Now, if you enjoy Pushing the Limits, if you get great value out of it, we would love you to come and join our Patron membership program. We've been doing this now for five and a half years and we need your help to keep it on air. It's been a public service free for everybody, and we want to keep it that way. But to do that we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on www.patron.lisatamati.com. That's P-A-T-R-O-N dot lisatamati.com. We have two Patron levels to choose from. You can do it for as little as $7 a month, New Zealand, or $15 a month if you really want to support us. So we are grateful if you do. There are so many membership benefits you're going to get if you join us. Everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries and much, much more. So check out all the details: patron.lisatamati.com. And thanks very much for joining us. You know, I'm still in that camp. Craig: You raise a really interesting point too, and that is programming and conditioning. And, you know, because we all grow up being programmed, one way or consciously or not, we grow— if you grow up around people, you're being programmed. So that's not a bad thing. That's an unavoidable human thing. So, situation, circumstance, environment, school, family, friends, media, social media, all of that stuff shapes the way that we see the world and shapes the way that we see ourselves.  When you grow up in a paradigm that says, ‘Okay, Lisa, when you finish school, you have to go to university, or you have to get a job, or you have to join the family business, or you have to work on our farm,' or whatever it is, you grow up in that. You're taught and told and trained. And so you don't question that, you know. And for me, I grew up in the 70s, I finished in the 80s. I finished school in 1981. And I grew up in the country, and most people go to trade or most people worked in logging or on a farm or— and I would say about five in 100 of the kids that I did— by the way, doing year 12 was a pretty big deal in that time. ‘Geez, are you a brainiac?' Definitely wasn't a brainiac. But year 12 is a big thing now. Now, even if you have an undergrad degree that it's almost nothing really enough. It's like, you kind of got to go get honours, or masters or maybe even a PhD down the track. And that landscape has really changed. So it's just changing again to— you know, and I think to become aware— like this is for me, I love it; this is my shit; this is what I love— is starting to become aware of our lack of awareness. And starting to become aware of my own programming and go, ‘Oh, I actually think this. Why not? Because this is how I naturally think about, because this is how I've been trained to think about work. I've been trained to or programmed to think this way about money, or relationships, or marriage, or eating meat, or being a Catholic or being an atheist or voting liberal law,' or whatever it is, right.  Not that any of those things are good or bad, but it's not about how I eat or how I vote or how I worship. It's about how I think. And is this my thinking? Or is this just a reflection of their thinking, right? So when we open the door on metacognition now we start to become aware of our own stories, and where they come from. And this is where I think we really start to take control of our own life, and our own present, and our own future that doesn't exist, by the way, but it will, but it won't be the present.  Then, we start to write our own story with our own voice, not our parents' voice, not our friends', not our peers' voice, you know. And we're always going to be influenced by other people. Of course. Just like people are influenced by you and your podcast, and your stories, and your thinking, and your lessons for them. They're influenced. But I always say to people, ‘Don't believe me because you like me. Listen to me, if you like me and consider what I say. If what I say sounds reasonable for you, maybe a good idea to test drive, take that idea for a test drive, and see if that works for you, because it might not.' Right?  I think, I really encourage people to learn for themselves and to listen to their own internal wisdom that's always talking. So listen to smart people. I don't know if Lisa and I are in that category, Lisa is, listen to her. But at the same time, do your own, learning through exploration and trial and error, and personal kind of curiosity and drive.  For me, I opened my first gym at 26; first personal training centre in Australia, there weren't any. I'd never done a business course, I've never done an admin course, I knew nothing about marketing. I knew nothing about employees. I knew nothing. But I learned more in one year than I would say, most people would learn in five years at university studying business, because I was in the middle of it, and I was going to sink or swim. So in one year, I started a business and I acquired overwhelming knowledge and skill because I had to, because of the situation. But that was all learning through doing.  The way that you've learned, you know you said earlier that, like, a lot of people think that they're not academic; therefore, they're not smart. Some of the smartest people I've ever met, and I don't— and this not being patronising, but like, mind-blowingly brilliant, how they think, live outside of academia. One of the reasons some people are so brilliant outside of academia is because they're not forced into an echo chamber of thought. They're living outside the academic paradigm, where we're not trying to restrict how you think or write or speak. There are no rules out here. So there's no intellectual inhibition.  Lisa: Yeah, I love that. Craig: When you do a PhD, like me, and I can separate the two, thankfully. But there's a way of communicating and writing in PhD land, which is incredibly restrictive because of the scientific process, which is fine, I get that. But it's having an awareness of— this is what I'm often talking to my supervisors about is, yes, I'm studying this thing, which is deep, deep neuropsychology, and everything, the way that you do your research, get your data or interpret your data. The whole process of creating new science, which is what you're doing as a PhD, creating, bringing something new into the world. That's one thing. But you write your journal articles, which is my PhD process, you get them, hopefully, you get them published in academic resources and magazines. But then, I don't want that to be it. I'm going to write a book when I finish about all of my research totally in layman's terms so that people can use the knowledge, so that people can— because that's the value.  For me handing in some papers and going, ‘Oh, Craig Harper is an academically published author.' That's cool, but it's not— and I'm so respectful of people who have had hundreds of things published, but that doesn't blow my socks off. I'm not really— like that's a real, you really hang your hat on that in academia. Oh, how many things he or she had published, publications, which is cool. They're all smarter than me. But I'm not. I'm like, yeah, that that's cool. But I want to connect with the masses, not the few. Also, by the way, people who read academic papers, they raise it— they're reading it generally, just like I am right now, for a specific reason which relates to their own research. There ain't too many people like you. You're one of the rare ones who just thumb through fucking academic journals to make your life better. Lisa: Yeah. And it's just some real goals. So you've got the wisdom of having lived outside of academia and being a pracademic, as Paul Taylor says, and then actually seeing the pre— and this is a discussion that I had when I was talking to someone about doing a PhD and they say, ‘But then you're going to become a part of the establishment, and you're going to be forced into this box.' And I said, ‘No, not necessarily because it's— I can see where you're coming from. But you can take that, because you have that maturity and that life experience and you can fit yourself into the box that you have to fit into in order to get those things done. That research done, but you don't have to stay there.'  That's what you know, one of my things has been, I don't want to spend however many years doing a PhD, and then that's not out on the world. To me that that needs to be taken out of the academic journals, wherever you go to publish, and then put out into a book or something that where it's actually shared, like you say, with the masses, because otherwise, it just collects dust like your MA does, or your whatever, you know, that sits on your bookshelf, and how you got hey, your exam your piece of paper, but you didn't actually do anything with it.  Of course, lots of people do their thing, they're going like they're in research, and they're furthering research and so on. But I— my approach, I think yours is too, is to be able to communicate that information that you've learned, and then share it with everyone, so that they can actually benefit from it, and not just the people that are in academia. The other thing I see after interviewing hundreds of doctors and scientists and people is that they are, actually, the more specialised they are, the more inhibited they are by what they can and can't say.  While they need to be doing that because they need to protect what they are doing in their studies and what they're allowed to and what they're not allowed to do and say, it also is very inhibiting, and they don't get the chance to actually express what they would actually like to say. That's a bit of a shame, really, because you don't get to hear the real truth in the qualifying everything flat stick. Craig: I reckon you're exactly right. But they don't need to be that. And the reason that a lot of academics are like that is because they get their identity and sense of self-worth from being an academic. They're way more worried about three of their peers hearing something that might not be 100% accurate, and then being reprimanded or, rather than just going— look, I always say to my academic, super academic friends, when I talk with them, not everything that comes out of your mouth needs to be research-based. You can have an idea and an opinion. In fact, I want to hear your ideas and opinions. Lisa: You're very educated. Craig: You know, that's the— and as for the idea of you becoming an academic, No, you go, you do your thing you study, you learn the protocol, the operating system, and you do that you go through that process, but you're still you. Right, and there's— you and I both know, there are lots of academics who have overcome that self-created barrier like Andrew Huberman.  Lisa: Yeah, who we love. Craig: Who we love, who, for people listening, he's @hubermanlab on Insta, and there's quite a few academics now, like the one that I spoke on before, on Joe Rogan. She's a Harvard professor, she's a genius, and she's just having a— it's a three-hour conversation with Rogan, about really interesting stuff.  There's been a bit of a shift, and there is a bit of a shift because people are now, the smart academics, I think, are now starting to understand that used the right way, that podcasts and social media more broadly, are unbelievably awesome tools to share your thoughts and ideas and messages. By the way, we know you're a human. If you get something wrong, every now and then, or whatever, it doesn't matter. Lisa: Well, we'll all get, I mean, you watch on social media, Dr Rhonda Patrick, another one that I follow? Do you follow her? Fantastic lady, you know, and you watch some of their feeds on social media, and they get slammed every day by people who pretending to be bloody more academic than her. That just makes me laugh, really. I'm just like, wow, they have to put up with all of that. The bigger your name and the more credibility you have as a scientist, the more you have to lose in a way.  You know, even David Sinclair another you know, brilliant scientists who loves his work. And I love the fact that he shared us with, you know, all his, all his research in real-time, basically, you know, bringing it out in the book Lifespan, which you have to read, in getting that out there in the masses, rather than squirrelling it away for another 20 years before it becomes part of our culture, and part of our clinical usage. We ain't got time for that. We have to, we're getting old now. I want to know what I need to do to stop that now. Thanks to him, you know, I've got some directions to show them. Whether he's 100% there, and he's got all the answers? No. But he's sharing where we're at from the progress. Science by its very nature is never finished. We never have the final answer. Because if someone thinks they do, then they're wrong, because they're not, we are constantly iterating and changing, and that's the whole basis of science. Craig: Well just think about the food pyramid. That was science for a few decades. Lisa: Lots of people still believe that shit. That's the scary thing because now that's filtering still down into the popular culture, that that's what you should be doing, eating your workbooks and God knows what. This is the scary thing, that it takes so long to drip down to people who aren't on that cutting edge and staying up with the latest stuff, because they're basically regurgitating what there was 20 years ago and not what is now.  Now Craig, I know you've got to jump off in a second. But I wanted to just ask one more question, if I may, we're completely different. But I want to go there today because I'm going through this bloody shingles thing. Your mate Johny that you train, and who you've spoken about on the last podcast, who had a horrific accident and amazingly survived, and you've helped him, and he's helped you and you've helped him learn life lessons and recover, but he's in constant chronic pain.  I'm in constant chronic pain now, that's two and a half weeks. For frick's sake, man, I've got a new appreciation of the damage that that does to society. I just said to my husband today, I've been on certain drugs, you know, antivirals, and in pain medication. I can feel my neurotransmitters are out of whack. I can feel that I'm becoming depressed. I have a lot of tools in my toolbox to deal with this stuff, and I am freely sharing this because what I want you to understand is when you, when you're dealing with somebody who is going through chronic pain, who has been on medications and antibiotics, and God knows whatever else, understanding the stuff that they're going through, because I now have a bit of a new appreciation for what this much of an appreciation for someone like Johnny's been through. What's your take on how pain and all this affects the neurotransmitters in the drugs? Craig: Do you know what? Lisa: You got two minutes, mate. Craig: I'm actually gonna give you I'm gonna hook you up with a friend of mine. His name is Dr Cal Friedman. He is super smart, and he specialises in pain management, but he has a very different approach, right? He's a medical doctor, but look, in answer to, I talked to Johnny about the pain a bit, and we have, we use a scale, obviously 10 is 10. 0 is 0. There's never a 0. Every now and then it's a 1 or 2, but he's never pain-free. Because he has massive nerve damage. And sometimes, sometimes he just sits down in the gym, and he'll just, I'll get him to do a set of something, and he'll sit down and I just see this, his whole face just grimaces. He goes, ‘Just give me a sec.' His fist is balled up. He goes, sweat, sweat. I go, ‘What's going on, mate?' He goes, ‘It feels like my leg, my whole leg is on fire.'  Lisa: Yeah. I can so relate to that right now.  Craig: Literally aren't, like, burning, like excruciating. I don't think there's any, I mean, obviously, if there was we'd all be doing it. There is no quick fix. There is no simple answer. But what he has done quite successfully is changed his relationship with pain. There is definitely, 100% definitely, a cognitive element to, of course, the brain is, because the brain is part of the central nervous system. Of course, the brain is involved. But there's another element to it beyond that, right.  I'm going to tell you a quick story that might fuck up a little bit of Dr Cal, if you get him on. He has done a couple of presentations for me at my camps. He's been on my show a little bit. But he told this story about this guy at a construction site that was working and he had a workplace accident. And he, a builder shot a three-inch nails through his boots, through his foot. Right? So the nail went through his foot, through the top of the leather, and out the sole, and he was in agony, right? He fell down, whatever and he's just rolling around in agony and his mates, they didn't want to take anything off because it was through the boot, through his foot.  They waited for the ambos to get there, and they gave him the green whistle. So you know that whatever that is, the morphine didn't do anything, he was still in agony. He was in agony. Anyway, they get him into the back of the ambulance and they cut the boot off. And the nail has gone between his big toe and second toe and didn't even touch his foot.  Lisa: Oh, wow. In other words, psychologically—  Craig: There was no injury. But the guy was literally in excruciating pain, he was wailing. And they gave him treatment, it didn't help. He was still in pain. So what that tells us— Lisa: There is an element of—  Craig: What that tells us is our body can, our mind can create real, not perceived, but real pain in your body. And again, and this is where I think we're going in the future where we start to understand, if you can create extreme pain in your body where there is no biological reason, there is no actual injury, there's no physical injury, but you believe there's an injury, now you're in agony.  I think about, and there's a really good book called Mind Over Medicine by a lady called Lissa Rankin, which we might have spoken about. L-I-S-S-A, Lissa Rankin, Mind Over Medicine. What I love about her is, she's a medical doctor, and she gives case after case after case of healing happening with the mind, where people think placebos and no-cebos, people getting sick, where they think they're getting something that will make them sick, but it's nothing, they actually make themselves sick. And conversely, people getting well, when they're not actually being given a drug. They're being given nothing, but they think it's something. Even this, and this is fascinating, this operation, pseudo-operation I did with people where—  Lisa: Yeah, I read that one. I read that study. Craig: Amazing. Craig: Oh, yeah, it's look, pain is something that even the people who are experts in it, they don't fully understand. Lisa: Well, I just like, if I can interrupt you there real briefly, because I've been studying what the hell nerve pain, and I'm like, my head, my sores are starting to heal up right. So in my head, I'm like ‘Whoa, I should be having this pain, I'm getting more pain from the burning sensation in my legs and my nerves because it's nerve pain.' So I read somewhere that cryotherapy was good. So in the middle of the night, when I'm in really bad pain, instead of lying there and just losing my shit, and have I now have been getting up every night and having two or three cold ice-cold showers a night, which probably not great for my cortisol bloody profile, but it's, I'm just targeting that leg. That interrupts the pain sensation for a few minutes.  What I'm trying to do as I go, I'm trying to go like, can I—am I getting pain because my brain is now used to having pain? Is it sending those messages, even though there's no need, the sores are healing?  Craig: That is possible. Lisa: Am I breaking? And I can break the pain for about 10 minutes, and then it will come back in again. But I'm continuing on with it, that idea that I can interrupt that pain flow. Then of course, during the breathe in, the meditation, the stuff and sometimes you just lose your shit and you lose it, and then you just start crying, ‘Mummy, bring me some chicken soup' type moments. But it's really interesting. I mean, I just like to look at all these shit that we go from and then say, ‘Well, how can I dissect this and make this a learning curve?' Because obviously, there's something wrong, but I just, I feel for people that are going through years of this. Craig: It's, yeah, I'm the same I feel. Sometimes I work with people, where I work with and as do you, I work with a lot of people who have real problems. I don't have any problems. I mean, they have real problems. And I'm, despite my appearance, I'm quite, I'm very compassionate. It's hard for me because I, it upsets me to see people in pain. I feel simultaneously sad and guilty. How do I deserve this? But it just is what it is. But people like John and a lot of the people that I've worked with and you've worked with, you know, people like that inspire me.  I mean, they're— I don't find typical heroes inspirational. They don't really inspire me like the people we normally hold up as, I mean, well done. I think they're great, but they don't inspire me. People who inspire me or people who really, how the fuck are you even here? How do you turn up? He turns up. He's actually in hospital right now because he's got a problem that's being fixed. But, and he's in and out of hospital all of the time. And then he turns up, he hugs me and he goes, ‘How are you?' I go, ‘I'm good.' He goes, ‘Now look at me.' So I look at him. And he goes, ‘How are you really?' And I go, ‘I'm good.' This is the guy who—  Lisa: Who's dealing with so much. I've got a friend, Ian Walker8, who I've had on the show, too, so he got hit by a truck when he was out cycling, I think it was years and years ago. He ended up a paraplegic. And then he recovered, he didn't recover, he's still in a wheelchair, but he was out racing his wheelchair, he did wheelchair racing, and he's part of our club and stuff. And then he got hit by another truck, now he's a quadriplegic.  This guy, just, he is relentless in his attitude, like he is, and I've seen him dragging himself like with his hands because he's got access now to his hands again. After working for the last couple of years, and he kind of, on a walker frame thing, dragging himself two steps and taking a little video of him, dragging his feet, not the feet out, working, they're just being dragged. But the relentless attitude of the guy, I'm just like, ‘You're a fricking hero. You're amazing. Why aren't you on everybody magazine cover? Why aren't you like, super famous?' Those people that really flip my boat. Craig: Yeah. And I

In this episode, we discuss the anti-aging information in the books, Ageless, The New Science of Getting Older Without Getting Old, by Andrew Steele published in 2020, and Lifespan, Why We Age and Why We Don't Have To, by David A. Sinclaire Ph.D. with Mathew D. LaPlante, Published in 2019. We go over the actual physical causes of what we have come to associate with "Old Age" as well as the recommended lifestyle practices which can counter the state of being we call aging. While the science is complicated the remedies are easy. It takes dedication and knowledge to educate yourself to live your best life. --- Send in a voice message: https://podcasters.spotify.com/pod/show/agingintelligently/message

David Sinclair is a Harvard researcher who believes aging is a treatable disease. His book Lifespan: Why We Age and Why We Don't Have To is available now.

Dr. David Sinclair is a world-renowned biologist and professor of genetics at Harvard Medical school and author of the book Lifespan: Why We Age and Why We Don't Have To.  Dr. Sinclair tells us how we can live forever and Whitney almost electrocutes him by spilling coffee on his biochip.  Plus, Whitney and Benton talk about meeting her lover's family in a slutty dress, a rogue pube, and announce her fall stand-up tour.   Check out David's website: www.doctorsinclair.com

Oxygen therapy to lengthen our telomeres and prolong the life of our chromosomes. Boosting the functioning of our mitochondria with NAD. Stem cell rejuvenation. These are just some of the exciting therapies that scientists are exploring in their quest to prevent the decline and suffering we experience as we age. But some scientists argue that these are just partial fixes and that the answer to the eternal quest for the fountain of youth lies in pinpointing the upstream driver of these hallmarks of ageing. They claim that thanks to breakthroughs in the science of genetics they have finally discovered the control system that generates the strength and health we associate with youth. It's the “epigenome”, which is the packaging that coils around our DNA and switches on and off the genes that shape the identity of our cells. They say that as we age this packaging unravels, which deregulates the DNA and cell information they have been safeguarding. Fix the packaging and we can completely reset our DNA and cells and regenerate our bodies so they are once again like brand new. Skeptics say that we need to look no farther than evolution to recognize that while ageing can be slowed down it can't be abolished. Despite the formidable powers of natural selection, a species that doesn't age and die has not emerged. This is because ageing is marked not just by cells that are slowing down but also by cells that are rapidly multiplying and becoming cancerous. It is impossible to fix one without the other benefiting, a form of intercell competition where human beings and our hopes of eradicating old age are the losers. Arguing for the motion is David Sinclair, Professor of Genetics at Harvard Medical School and one of TIME Magazine's “Top 50 people in health care”. He is the author of over 200 scientific papers as well as the New York Times bestseller Lifespan: Why We Age—and Why We Don't Have To. Arguing against the motion is Joanna Masel, Professor of Ecology & Evolutionary Biology at the University of Arizona. She is a mathematical modeller who has published over 50 papers in a variety of scientific fields and is the author of Bypass Wall Street: A Biologist's Guide to the Rat Race. Sources: ZNews, Fox News, WKTV Newschannel2, Science Time The host of the Munk Debates is Rudyard Griffiths - @rudyardg.   Tweet your comments about this episode to @munkdebate or comment on our Facebook page https://www.facebook.com/munkdebates/ To sign up for a weekly email reminder for this podcast, send an email to podcast@munkdebates.com.   To support civil and substantive debate on the big questions of the day, consider becoming a Munk Member at https://munkdebates.com/membership Members receive access to our 10+ year library of great debates in HD video, a free Munk Debates book, newsletter and ticketing privileges at our live events. This podcast is a project of the Munk Debates, a Canadian charitable organization dedicated to fostering civil and substantive public dialogue - https://munkdebates.com/ The Munk Debates podcast is produced by Antica, Canada's largest private audio production company - https://www.anticaproductions.com/   Executive Producer: Stuart Coxe, CEO Antica Productions Senior Producer: Christina Campbell Editor: Kieran Lynch Producer: Nicole Edwards Associate Producer: Abhi Raheja

I'm covering David Sinclair's new book, "Lifespan: Why We Age—and Why We Don't Have To." Contained here are some interesting theories and discussions about aging and age-related diseases.  I also touched on the topics of Valter Longo's Prolon FMD (fasting-mimicking diet), vitamin K2 carboxylation and vitamin K2-dependent enzymes, inflammation tests (Hs-CRP, MPO, Lp-PLA2, and MACR), the secret life of fat cells, and niacin. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

How does the body age? There are many theories about the aging process. In his new book "Lifespan: Why We Age—and Why We Don't Have To," longevity researcher Dr. David Sinclair discussed interesting concepts, like the information theory of aging and the so-called "zombie cells."  For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

In dieser Folge von Female Future Finance hat Agnieszka mit Ellen Kuder, Vice President DACH von Afterpay, über das Thema Payments gesprochen. Wie haben sich die Bedürfnisse der Kunden verändert, vor allem durch den Digitalisierungsschub, ausgelöst von der Pandemie? Warum ist der Trend rund um das Prinzip Buy Now, Pay Later so beliebt und welche Zielgruppe wird hier angesprochen? Welche Ökosysteme können sich durchsetzen und wie positioniert sich AfterPay dahingehend? Welche Trends lassen sich derzeit im Payments-Bereich ausmachen? Und: Wie sieht ein Einkauf in zehn Jahren aus? • Wie haben sich die Bedürfnisse von Nutzerinnen und Nutzer durch die Pandemie verändert? • Was hat es mit der „Renaissance“ von Kauf auf Rechnung auf sich, welche Zielgruppe findet sich hier? • Welche neuen Trends gibt es im Bereich Payments derzeit? • Zum Thema Ökosysteme: Welches wird sich am ehesten durchsetzen können? • Was hat es mit “Data-Driven Offers” auf sich? • Wie kann man bei Zahlungen im Hintergrund Transparenz schaffen? • Wir wird man in zehn Jahren einkaufen – und wie für den Einkauf dann wohl bezahlen? --- Die Buchempfehlungen von Ellen Kuder: David A. Sinclair: “Lifespan: Why We Age―and Why We Don't Have To” (https://www.amazon.de/Lifespan-Why-Age_and-Dont-Have/dp/1501191977) Celeste Headlee: “We Need to Talk: How to Have Conversations That Matter” (https://www.amazon.de/We-Need-Talk-Conversations-Matter/dp/0062669001) Celeste Headlee: “Speaking of Race: Why We Need to Talk About Race-and How to Do It Effectively” (https://www.amazon.com/Speaking-Race-About-Race-Effectively-ebook/dp/B08VNMFCDF, Erscheinungstermin 02.11. 2021) Der Ted-Talk von Celeste Headlee (https://www.ted.com/talks/celeste_headlee_10_ways_to_have_a_better_conversation) Alle weiteren Folgen, Infos und Kontaktmöglichkeiten hier: www.femalefuturefinance.creativeconstruction.de Feedback, Fragen, Wünsche und Ideen bitte an: podcast@femalefuturefinance.de

This is part 3 of our series on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." We'll talk about 3 concepts—rapamycin, mTOR, autophagy. Rapamycin (an antibiotic) inhibits mTOR (a protein). mTOR inhibits autophagy. Autophagy is a natural process by which the body eliminates unnecessary components (like dead mitochondria). So, does rapamycin have an effect on aging and longevity? That's what we'll discuss in the podcast.  For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

In this episode, I have the pleasure to interview Dr. David Sinclair. David is a professor in the Department of Genetics at Harvard Medical School. Time magazine has named him one of the 100 most influential people in the world and among the top 50 people in healthcare. He and his colleagues study sirtuins - protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction - as well as other subjects like learning, memory, neurodegeneration, cancer and cellular reprogramming. Our conversation today is all about his book Lifespan: Why We Age - and Why We Don't Have To. David believes that aging is a disease and that we may soon have the tools to put it into remission. This has been one of my favorite conversations to date. Please enjoy this amazing conversation with Dr. David Sinclair. Today's episode is sponsored by Audible. Try Audible for free: www.bookthinkers.com/audibletrial. The purpose of this podcast is to connect you, the listener, with new books, new mentors, and new resources that will help you achieve more and live better. Each and every episode will feature one of the world's top authors so that you know each and every time you tune-in, there is something valuable to learn. If you have any recommendations for guests, please DM them to us on Instagram. (www.instagram.com/bookthinkers) If you enjoyed this show, please consider leaving a review. It takes less than 60-seconds of your time, and really makes a difference when I am trying to land new guests. For more BookThinkers content, check out our Instagram or our website. Thank you for your time!

本期节目的嘉宾是我们的朋友黄宇翔。黄宇翔是美国密歇根大学安娜堡分校分子、细胞与发育生物学的博士学生，主要研究方向是细胞代谢。他也是科学新媒体"知识分子"的撰稿人，目前正在创作《科研外史》，一部以科学史为主题，以武侠为风格的非虚构文集。“有人的地方就有江湖。”作为一门实验科学，生物科研的江湖是什么样的？为什么在黄宇翔看来，生物化学法和遗传学法分别对应降龙十八掌、掷暗器这样的绝顶武功？如果科研史是一部武侠小说，它的精神内核是什么？如果说做研究也是修行，研究者以什么为目标、如何理解自己的角色？在广为人知的科学结论背后往往是无数次失败的经历，而这些探索的过程恰恰构成了科学的基石。为什么这些经历值得被记录、为什么科普写作是重要的？在传递事实信息之外，科普写作又如何传递知识？从高中生物与生物学研究的区别讲起，黄宇翔和我们在这期节目中聊到了科研观、研究者身份、科研武侠、科普写作等话题。本期嘉宾黄宇翔内容提要+精彩预告01:15 生物科学的研究和高中生物课程有什么区别？“说生命科学是文科是完全错误的概念。生物学是一门实验科学，高中生物学课本上的每一个概念背后都有实验支持。高中生物学课本上过度强调了结论性的东西，使得很多人对生物失去了兴趣。”“本科生物学训练强调知识是怎么来的这一过程。”“十九世纪以前的生物学研究叫natural history，自然史或者博物学，是非常描述性的研究。这和当代强调逻辑和抽象概念的生物学研究有所不同。”“生物学上没有百分之百确定的东西，都是在限定条件下的结论。”06:40 生物医学的原创性和重要性“真正开创领域的工作在刚刚发现的时候大部分人无法认识到其重要性。”“作为细胞自噬这个现象最最早发现的人之一，我的导师在90年代观察到这个现象的时候还觉得很郁闷，因为人们不觉得它重要。直到90年代末，人们发现细胞自噬与癌症发病原因的关系，才意识到这个生理学过程的重要意义。”10:58 什么事值得研究的？-不同科学家的科研观“分子生物学的先驱Max Delbrück说过Don't follow the fashion science. 一个科研问题如果大部分人都知道它重要了，那就不要去研究他了。因为有没有你，也会有人能做出来。”“生物学研究的很多竞争很像武侠小说中的华山论剑。大家都想争取第一，但是通过不同的途径。”“生物化学途径像降龙十八掌，是非常霸道的外家功夫，从上百升的培养液中提取中不同的组份进行实验。思路比较简单，但是比较消耗内力。”“遗传学像剑或是暗器，通过化学物质诱发随机突变探索克隆基因的方法。”“两种方法思路非常不一样，但是殊途同归，几乎是同一时间把同一基因克隆出来并一起获得了2001年的诺贝尔生理学奖。”20:20 对武侠的兴趣：做研究也是修行“生物学研究大部分时候是很重复且枯燥的。研究是Re-search，需要你一次又一次的去探索。”“关于武侠的联想是我在科研中找乐子的方法。”“科研大部分时候还是很艰苦的。探究知识的边界大多会以失败收尾，给自己找一些正反馈就很重要。”29:20 生物医学武侠的精神内核：“为苍生的健康谋福利”“从大的学科角度说生物医学研究以科学为手中的宝剑，以愚昧无知作为敌人，为苍生的健康谋福利。从个人的角度说，武侠小说是成年人的童话。我未必能成为封号斗罗或绝世大侠，我也没有天资聪颖，可能放在武侠小说里就是路人甲。我能做到的就是努力把自己的武功练扎实，能做到无愧于心，不要浪费有限的武功，不要让时光虚度掉。做些有益的事情，在过程中充实自己享受过程。”32:00 从《斯通纳》一个本关于学者的一生的小说中获得的启发“不是每个人都要成为那个站在山顶上的人。做自己的英雄，去做一些有益于社会事情。焚膏油以继晷，恒兀兀以穷年。也是一种很好的人生选择。”34:00 对科普写作的兴趣“最开始写科学史科普的时候是出于对学术文章背后科研探索过程的好奇。”“文章是很清晰的，但是探索的过程是曲折的。”“在接近崩溃的时候，如何通过身边人的鼓励而坚持下来。”“一个项目可能六七年前就开始做了，研究幕后的故事细节可能研究者本人都不太记得。但艰苦的奋斗过程如果不记录下来就太可惜了，这都是人类奋斗的经历”39:32 科普写作与播客节目“科普写作和播客都是希望记录冷冰冰的研究背后生动的人和事”“写科普也是希望把理性的科学逻辑传递给大家。”“研究的意义可能在回顾的时候才能够更加清楚，借助导师的见解也很重要。”“科学的前沿是通过武艺的切磋，互相的批评而推进的。“45:40 生物科学科学所理解的科学是什么样的？“生物科学的底层逻辑是必要性、充分性。”46:40 科普不是什么？“科普不是fact，是knowledge：科学中的结论是怎么来的，如何把fact整合成knowledge的过程是科普真正想传递的。这些科学思维可以帮助我们更理性地思考一些现象。”“有人给你展现了一段推理的过程，你可以思考它是不是有道理。这是科普想要传达的思维。”“我们要明白这个结论在什么条件下才成立。一个结论常常只是在一个很小的范围内才成立的。写科普的一大动力是希望大家能以更批判的角度看待问题。”50:40 做科普的感受“做科普写作对自己最直接的影响是增长了自己的科研修养，武器库，扩充了自己的科研思路。”“通过采访老科学家一路的科研生涯也拓宽了我对于科学作为一种职业的的理解。”52:40 总结“科学是一个过程，它的背后是很多有血有肉、像我们一样普通的平凡人。”54:00 书籍推荐Li, J. J. (2006). Laughing gas, Viagra, and Lipitor: The human stories behind the drugs we use. Oxford University Press. “药物发现背后的故事”Sinclair, D. A., & LaPlante, M. D. (2019). Lifespan: Why We Age—and Why We Don't Have To. Atria Books. “明星科学家实验室背后的故事；关于衰老医学的见解。”Ribatti, D. (2018). Judah Folkman: A Biography. Springer. “一位医生科学家的传记。”参考资料黄宇翔在知识分子发表的文章列表：http://zhishifenzi.com/u/2425.html李少峰. (2017年09月28日). "知乎大v王立铭:相信伪科学只需要本能". 长江日报. Retrieved from: http://www.cjrbapp.cjn.cn/p/1694.html片头片尾音乐《Sunrise at Seaside》by 王乾-----------双重意识是一档「让我们认识到那些我们以为此时此刻与我们生活需求没有关联的东西其实和我们紧密相关」的播客节目。你可以在苹果播客, 喜马拉雅，网易云音乐，荔枝fm，小宇宙APP和Spotify搜索"双重意识DoubleConsciousness"找到我们，关注我们并收听我们的节目。欢迎大家在微信后台或是微博(@双重意识DoubleConsciousness)等各大平台给我们留言、提供反馈意见。

Metformin is a popular anti-diabetes medication. But it is also said to be an anti-aging drug. This podcast is based on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." Here, we'll talk about metformin, metformin's benefits, multiple metabolic pathways impacted by metformin, and the TAME study (Targeting Aging with Metformin).For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's metformin articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

Metformin is a popular anti-diabetes medication. But it is also hailed as an anti-aging drug too. This podcast is based on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." We'll talk about metformin, metformin's benefits, multiple metabolic pathways impacted by metformin, and the TAME study (Targeting Aging with Metformin).For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's blog articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

Chelsea Handler has been a long time client of Christine and Jamie. Christine worked on her Netflix show “Chelsea” traveling the world with her doing her hair. She quickly realized that Chelsea was way more than just a pretty face. Her long list of attributes include multiple time NY times #1 best selling Author, Actress, TV show Host, activist, entrepreneur, Documentarian, and all around bad ass. We find it hard to believe she finds time for it all, but time after time she proves us wrong. During this episode we find out how she defies the aging process and what's next on her list to conquer. With her new found love of meditation and marijuana, the world really should take some notes from this new side of Handler that they've never seen. Shop the Episode Native Deodorant Megababe Deodorant Castor Oil Pill of Youth Resveratrol "Lifespan: Why We Age―and Why We Don't Have To" by David A. Sinclair PhD Headspace Meditation App All Amazon links provided are part of our Amazon Affiliate partnership. The Make Down earns a small commission at no extra cost to you.  Thanks in advance for helping to support this free podcast!

El coronavirus nos obliga a teletrabajar y a analizar nuevas soluciones a las situaciones de antifragilidad que estamos viviendo, pero no ha impedido que una semana más nos encontremos, en esta ocasión en formato virtual, para hacer nuestro podcast. [amazon_link asins='8408149636,B07MBV5JR3,8408008544' template='ProductCarousel' store='zetatesters_-21' marketplace='ES' link_id='835227f2-a365-41f9-8ab0-4e867958f30d'] No os contaremos cómo @granludo  llegó a dar con esta delicatessen, pero seguro que os va a encantar conocer a David Sinclair, un biólogo profesor de genética de la universidad de Harvard que lleva más de 25 años investigando en cómo frenar el envejecimiento. El pasado mes de septiembre Sinclair publicó su libro Lifespan. Why We Age- and Why We Don't Have To donde explica por qué envejecemos y cómo aunque no sea un proceso imparable se puede combatir. [amazon_link asins='B07N4C6LGR' template='ProductCarousel' store='zetatesters_-21' marketplace='ES' link_id='42e76312-5974-45e6-9d24-74c1aa4c479c']  Para Sinclair envejecer es una enfermedad y como tal se debería tratar de manera global y no segmentada. Su investigación propone estimular las defensas naturales del organismo frente al deterioro del ADN para activar los genes que protegen y reparan las celulas. Extender la vida es un efecto secundario de la longevidad por ello Sinclair prueba con su propio cuerpo distintas sustancias, entre ellas el Resveratrol, el NMN (Nicotinamida mononucleótida) y la Metmorfina que le hacen mantener un aspecto mucho más joven. Si no te atreves a hackear tu cuerpo después de leer su libro seguro que comiendo un poco menos, haciendo ejercicio y pasando algo de frío puedes sentirte algo mejor. El peso de la genética en la esperanza de vida sólo supone un 20%, así que tener buenos hábitos seguro que te va ayudar a vivir más. ¿Sabíais que nuestras células están diseñadas para vivir 120 años? Estas y otras curiosidades más te las explicamos esta semana.

David A. Sinclair, Ph.D., is one of the world's most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him "one of the 100 most influential people in the world" (2014) and among the "Top 50 People in Healthcare" (2018). New York Times Bestselling author of Lifespan: Why We Age―and Why We Don't Have To.David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you'd most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world's top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab's discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing--and what that means for humanity going forward.He's applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results-- which, it should be noted, are completely anecdotal--are encouraging. He's now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award.- https://lifespanbook.com/Catch my book - Screw Being Shy, March 14th on my website markmetry.comPlease do NOT hesitate to reach out to me for any reason on LinkedIn, Instagram, via email mark@vudream.com, text me 508-925-0261!LinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast

Dr. David Sinclair is author of "Lifespan: Why We Age and Why We Don't Have To" Dr. Sinclair was named one of Time Magazine's "Most Influential" people. This Harvard researcher reveals a bold new theory on why we age and talks to Cristina about his cutting edge research on how to extend our lifespans. He also reveals something about himself not heard in any other interview.

David A. Sinclair, Ph.D., co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, has been listed in TIME magazine's “100 most influential people in the world” (2014), and appeared on their list of the "Top 50 in Healthcare" (2018). Dr. Sinclair is best known for his work into anti-aging and longevity, putting forth the idea that aging is a disease and we can uncover the tools to put it into remission. His book "Lifespan: Why We Age - and Why We Don't Have To" is a New York Times Bestseller. Full show notes: Dr. Sinclair|Mind-Jam Podcast

Today's guest is David Sinclair, professor of genetics at Harvard Medical School and co-director of the Paul Glenn Center Biological Mechanisms of Aging. He is widely considered on the world's foremost experts on longevity research. A co-founder of the journal Aging and several biotech companies, he also hold 35 patents. Dr. Sinclair is a recipient of more than 25 awards and honors, including being knighted in the Order of Australia. His work is featured in five books, two documentary movies, “60 Minutes,” Morgan Freeman's “Through the Wormhole,” and other media. His newest book, LifeSpan. Why We Age and Why We Don't Have To, was released in September 2019 by Simon and Schuster. Colin Miller and Dr. Keith Mankin host the popular medical podcast, PeerSpectrum. Colin works in the medical device space and Keith is a retired pediatric orthopedic surgeon. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's guest is David Sinclair, professor of genetics at Harvard Medical School and co-director of the Paul Glenn Center Biological Mechanisms of Aging. He is widely considered on the world's foremost experts on longevity research. A co-founder of the journal Aging and several biotech companies, he also hold 35 patents. Dr. Sinclair is a recipient of more than 25 awards and honors, including being knighted in the Order of Australia. His work is featured in five books, two documentary movies, “60 Minutes,” Morgan Freeman's “Through the Wormhole,” and other media. His newest book, LifeSpan. Why We Age and Why We Don't Have To, was released in September 2019 by Simon and Schuster. Colin Miller and Dr. Keith Mankin host the popular medical podcast, PeerSpectrum. Colin works in the medical device space and Keith is a retired pediatric orthopedic surgeon. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine