Podcasts about lifespan why we age

Dr. David Sinclair is a leading world authority on aging and longevity. He is Professor of Genetics at Harvard Medical School. David is the author of Lifespan: Why We Age - and Why We Don't Have To & the host of Lifespan podcast. Show sponsor: LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Show notes: https://ultimatehealthpodcast.com/617

In today's episode of Category Visionaries, we speak with James Bates, CEO and Founder of AdviNOW Medical, an AI healthcare automation company that's raised $24 Million in funding. Topics Discussed: James' background in the healthcare industry, including experience working in Japan and what it taught him Why so many physicians spend a significant portion of their time on clerical work and regulatory tasks, rather than delivering care Burnout and stress in the medical sector, and why freeing up physicians with automation means a higher quality, as well as more quantity, care How AdviNOW aims to mimic the brain functions of their potential clients in medical care and administration The future of healthcare in an automation-first economy, and what innovation means for everyone's medical experience   Favorite book:  Lifespan: Why We Age―and Why We Don't Have To

She's been a journalist, an editor, a columnist, a novelist -- someone who sees the world and writes it down. Seema Goswami joins Amit Varma in episode 346 of The Seen and the Unseen to talk about her life and times, and what they taught her. (FOR FULL LINKED SHOW NOTES, GO TO SEENUNSEEN.IN.) Also check out: 1. Seema Goswami on Twitter, Instagram, Amazon and her own site. 2. Seema Goswami's column in HT Brunch. 3. Woman on Top -- Seema Goswami. 4. Race Course Road -- Seema Goswami. 5. Madam Prime Minister -- Seema Goswami. 6. The Life and Times of Shanta Gokhale — Episode 311 of The Seen and the Unseen. 7. One Foot on the Ground — Shanta Gokhale's brilliant memoir. 8. I Feel Bad About My Neck -- Nora Ephron. 9. Swim against the stereotypes -- Seema Goswami. 10. Zeenat Aman on Instagram. 11. The Culture Code --  Clotaire Rapaille. 12. Jane Austen on Amazon and Wikipedia. 13. Photographic memory -- Seema Goswami. 14. Cameo: Personalized videos from your favorite stars. 15. The West Wing -- Aaron Sorkin. 16. The Prem Panicker Files — Episode 217 of The Seen and the Unseen (w Prem Panicker). 17. Kohrra and Dahaad. 18. Natasha Badhwar Lives the Examined Life — Episode 301 of The Seen and the Unseen. 19. Self-Portrait — AK Ramanujan. 20. The Complete Works of George Bernard Shaw. 21. Georgette Heyer, Enid Blyton, Nancy Drew, James Hadley Chase and Alistair MacLean on Amazon. 22. SJ Bennett's murder mysteries. 23. Manu Pillai on Amazon and The Seen and the Unseen (1, 2, 3, 4). 24. Madhulika Liddle's Muzaffar Jang mysteries. 25. The Malory Towers collections by Enid Blyton: 1, 2, 3, 4. 26. The Gell-Mann Amnesia Effect. 27. Aakash Singh Rathore, the Ironman Philosopher -- Episode 340 of The Seen and the Unseen. 28. Lifespan: Why We Age – and Why We Don't Have To — David Sinclair. 29. Outlive: The Science and Art of Longevity — Peter Attia. 30. Peter Attia on the Huberman Lab Podcast. 31. Pandemic Praise -- Seema Goswami. 32. Blooming Glory -- Seema Goswami. 33. The Life and Times of Vir Sanghvi — Episode 236 of The Seen and the Unseen.  34. Why I Loved and Left Poker — Amit Varma. 35. The archives of Amit Varma's poker column for the Economic Times, Range Rover. 36. Amarcord -- Federico Fellini. 37. Pushpesh Pant Feasts on the Buffet of Life — Episode 326 of The Seen and the Unseen. 38. The Indianness of Indian Food — Episode 95 of The Seen and the Unseen (w Vikram Doctor). 39. Chourangi, Dhamaka and Semma. 40. The Slow Fire Chef on Twitter. 41. Mahabelly, Savya Rasa and Jamun. 42. The Romantic Idiot -- Samarth Bansal. 43. Cut the Clutter with Shekhar Gupta. 44. Mojo Story on YouTube. 45. Faye D'Souza on YouTube and Instagram. 46. Faye D'Souza doing stand-up comedy on One Mic Stand. 47. Larking About -- Seema Goswami. 48. Amitava Kumar Finds the Breath of Life — Episode 265 of The Seen and the Unseen. 49. Films, Feminism, Paromita — Episode 155 of The Seen and the Unseen (w Paromita Vohra). 50. The Poetic Feminism of Paromita Vohra — Episode 339 of The Seen and the Unseen. 51. Seema Goswami's Instagram post on her mother and grandmother. 52. The Simple Knot -- Seema Goswami. 53. Desperately Seeking Shah Rukh — Shrayana Bhattacharya. 54. The Loneliness of the Indian Woman — Episode 259 of The Seen and the Unseen (w Shrayana Bhattacharya). 55. The Imitation Game -- Seema Goswami. 56. Wanting — Luke Burgis. 57. Luke Burgis Sees the Deer at His Window — Episode 337 of The Seen and the Unseen. 58. René Girard on Amazon and Wikipedia. 59. The Life and Times of Nilanjana Roy — Episode 284 of The Seen and the Unseen. 60. Shashi Tharoor on Amazon. 61. The Paradox of Narendra Modi — Episode 102 of The Seen and the Unseen (w Shashi Tharoor). 62. Kashi Ka Assi — Kashinath Singh. 63. Kathal: A Jackfruit Mystery -- Yashowardhan Mishra. 64. Daniel Silva, Clare Mackintosh and Elizabeth Jane Howard on Amazon. This episode is sponsored by CTQ Compounds. Check out The Daily Reader and FutureStack. Use the code UNSEEN for Rs 2500 off. Amit Varma and Ajay Shah have launched a new video podcast. Check out Everything is Everything on YouTube. Check out Amit's online course, The Art of Clear Writing. And subscribe to The India Uncut Newsletter. It's free! Episode art: ‘Write it Down' by Simahina.

She's a filmmaker, feminist, artist, writer -- impossible to pin down, a connoisseur of multitudes. Paromita Vohra joins Amit Varma in episode 339 of The Seen and the Unseen to shoot the breeze and share her thoughts on Covid, relationships, the garden of consent, how being a misfit can be liberating and what she means by Poetic Feminism. (FOR FULL LINKED SHOW NOTES, GO TO SEENUNSEEN.IN.) Also check out: 1. Paromita Vohra on Twitter, Instagram, LinkedIn, IMDb and Parodevi Pictures. 2.  Paromita Vohra's column archives in Mid-Day. 3. Agents of Ishq. 3. Films, Feminism, Paromita -- Episode 155 of The Seen and the Unseen (w Paromita Vohra). 4. Unlimited Girls (95 mins). 5. Partners in Crime (95 mins). 6. Paromita Vohra interviewed by The Third Eye. 7. Empire of the Sun -- Steven Spielberg. 8. Simple Recipes for Complicated Times -- Peter Griffin's Facebook group. 9. Tsunami Help and Cloudburst Mumbai. 10. Feeding the Hungry in the Pandemic — Episode 210 of The Seen and the Unseen (w Ruben Mascarenhas). 11. The Life and Times of Abhinandan Sekhri — Episode 254 of The Seen and the Unseen. 12. Chekhov's Gun. 13. Natasha Badhwar Lives the Examined Life — Episode 301 of The Seen and the Unseen. 14. Padosan and Kashmir Ki Kali. 15. The Life and Times of Shanta Gokhale — Episode 311 of The Seen and the Unseen. 16. One Foot on the Ground — Shanta Gokhale. 17. Men Are from Mars, Women Are from Venus — John Gray. 18. What Makes Women Happy -- Fay Weldon. 19. The Loneliness of the Indian Woman — Episode 259 of The Seen and the Unseen (w Shrayana Bhattacharya). 20. The Loneliness of the Indian Man — Episode 303 of The Seen and the Unseen (w Nikhil Taneja). 21. Asterix, Tintin, Phantom and Mandrake. 22. Midnight's Children -- Salman Rushdie. 23. Shame -- Salman Rushdie. 24. Amitav Ghosh on Amazon. 25. Anjali Arondekar on Amazon and her own website. 26. Sex, Law, and the Politics of Age: Child Marriage in India, 1891–1937 -- Ishita Pande. 27. Indian Sex Life -- Durba Mitra. 28. The Looking-Glass Self. 29. The Four Quadrants of Conformism — Paul Graham. 30. Miss Excel on Instagram and TikTok. 31. How an Excel Tiktoker Manifested Her Way to Making Six Figures a Day — Nilay Patel. 32. Tokyo is the new Paris -- Noah Smith. 33. Maximum City -- Suketu Mehta. 34. Kuch Kuch Hota Hai — Karan Johar. 35. Supermen of Malegaon -- Faiza Ahmad Khan. 36. The Overton Window. 37. The Indianness of Indian Food — Episode 95 of The Seen and the Unseen (w Vikram Doctor). 38. The Refreshing Audacity of Vinay Singhal — Episode 291 of The Seen and the Unseen. 39. Stage.in. 40. On Exactitude in Science — Jorge Luis Borges. 41. On Uniform Civil Code, intent matters -- GN Devy. 42. Past Lives --  Celine Song. 43. Joseph Fasano on Twitter. 44. Imaginary Number — Vijay Seshadri. 45. Therigatha: Poems of the First Buddhist Women -- Translated by Charles Hallisey. 46. Early Indians — Episode 112 of The Seen and the Unseen (w Tony Joseph). 47. Early Indians: The Story of Our Ancestors and Where We Came From — Tony Joseph. 48. Why Children Labour (2007) -- Amit Varma. 49. The Life and Times of Urvashi Butalia — Episode 287 of The Seen and the Unseen. 50. Manjima Bhattacharjya: The Making of a Feminist -- Episode 280 of The Seen and the Unseen. 51. Roots -- Alex Haley. 52. Lifespan: Why We Age – and Why We Don't Have To — David Sinclair. 53. Outlive: The Science and Art of Longevity -- Peter Attia. 54. Chronicle of a Summer -- Jean Rouch and Edgar Morin. 55. Chaalbaaz -- Pankaj Parashar. 56. Topsy-Turvy -- Mike Leigh. 57. Your Emergency Contact Has Experienced an Emergency -- Chen Chen. 58. i love you to the moon & -- Chen Chen. 59. Chen Chen on Instagram. 60. Rajendra Krishan on Wikipedia, IMDb and Rekhta. 61. Pyar Ke Jahan Ki Nirali Sarkar Hai -- Song from Patang, written by Rajendra Krishan. 62. Ga Ga Ga Gori Gori -- Baba Sehgal. 63. Ek Thi Ladki -- Roop Shorey. 64. Lara Lappa Lara Lappa -- Song from Ek Thi Ladki. 65. The Incredible Curiosities of Mukulika Banerjee — Episode 276 of The Seen and the Unseen (w Mukulika Banerjee). 66. Regrets, None -- Dolly Thakore. 67. Timepass: The Memoirs of Protima Bedi -- Protima Bedi. 68. Joan Didion on Amazon. 69. The Odd Woman and the City — Vivian Gornick. 70. We Should All Be Feminists -- Chimamanda Ngozi Adichie. 71. Fearless Freedom -- Kavita Krishnan. Amit Varma and Ajay Shah have launched a new video podcast. Check out Everything is Everything on YouTube. Check out Amit's online course, The Art of Clear Writing. And subscribe to The India Uncut Newsletter. It's free! Episode art: ‘The Dance of Life' by Simahina.

David Sinclair is a professor of genetics at Harvard Medical School and the founder of the Sinclair Lab. He's the author of the bestselling book Lifespan: Why We Age—and Why We Don't Have To, as well as a founder of several biotech companies. Auren and David discuss the potential to expand the average human lifespan by decades. David challenges traditional notions of aging and emphasizes the need to embrace new technologies. They also discuss the benefits and drawbacks of common anti-aging practices like interval training, fasting, and stress reduction. David shares his thoughts on what longevity medicines and supplements are most beneficial, and how to talk to your doctor about them. He breaks down which health metrics to monitor in treating and preventing aging. Overall, David offers an incredibly optimistic vision for what the future of aging could look like, and the science it will take to get there. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and David Sinclair on Twitter at @davidasinclair 

On the first episode of Season Three of ‘We're Not Blowing Hot Air,' Dr. Jordan Shilts, Founder of Statera Health – a clinic specializing in functional medicine in Edina, Minnesota – chats with Lauren Carlstrom and new co-host, Robert Burns, about how and why we can live longer than we think!  Dr. Jordan explains the difference between lifespan and healthspan, chronological age versus biological age, and what we can do to win at the game of life.  Plus, learn why goals are at the crux of helping us live a long, healthy, happy life – all on this episode of ‘We're Not Blowing Hot Air.'About Dr. Jordan Shilts:Dr. Jordan Shilts is Founder of Statera Health – a clinic specializing in functional medicine in Edina, Minnesota.  Dr. Jordan incorporates chiropractic care, brain-based therapies, nutrition, and movement into his holistic treatments to extend his patient's healthspan and improve quality of life.  His goal is to make longevity practices effective, simple and accessible.  His unique approach promotes foundational pillars of health (sleep, autonomic functions and recovery) while simultaneously improving his patient's mindset towards lifestyle change.  Dr. Jordan graduated with his Doctor of Chiropractic from Northwestern Health Sciences University in Bloomington, Minnesota.  He received his B.S. in Kinesiology from Winona State University.  Dr. Jordan is certified in nutrition and applied kinesiology and is dedicated to furthering his education.  He is actively finalizing his M.S. in Exercise Science, performing thesis research in autonomic nervous system function, and currently pursuing a diplomate in Functional Neurology.Learn more Statera Health:  https://officialstatera.com/ Follow Statera Health on Instagram:  https://www.instagram.com/staterahealth_edina/ This podcast references, and suggests reading, the book, Lifespan: Why We Age―and Why We Don't Have To' by Dr. David Sinclair. "In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: 'Aging is a disease, and that disease is treatable.'"Follow Oxygen Plus (O+) on Instagram at @oxygenplus and on TikTok @oxygenpluso2

Watch the Full Episode for FREE: Dr David Sinclair - Lifespan: Why We Age & Why We Don't Have To - London Real 

เราเคยเชื่อกันว่า “ความแก่” คือสิ่งที่ทุกคนต้องเผชิญเมื่ออายุมากขึ้น แต่วิทยาศาสตร์ในยุคปัจจุบันเห็นต่าง เพราะมีการค้นพบว่าความแก่นั้นชะลอได้ . ทำความเข้าใจความแก่กันอีกครั้งผ่านทฤษฎีใหม่ ของดอกเตอร์เดวิด ซินแคลร์ จาก Harvard Medical School เจ้าของหนังสือชื่อดัง Lifespan: Why We Age, and Why We Don't Have To พร้อมเคล็ดลับหลากหลายวิธีที่จะช่วยให้เรา “แก่ช้า อายุยืน” . เชิญรับฟังพร้อมๆ กันได้ใน Mission To The Moon EP. นี้ . การหมั่นตรวจสุขภาพก็เป็นอีกหนึ่งวิธีที่ช่วยให้เราดูแลตัวเองได้ตรงจุด รักษาสุขภาพให้แข็งแรงและดูดี แม้จะมีอายุมากขึ้น หากสนใจโปรแกรมตรวจสุขภาพ “All You Can Check” สามารถสอบถามรายละเอียดเพิ่มเติมที่ รพ.พญาไท-เปาโล Call Center โทร. 1772 หรือ Website ของทั้งรพ.พญาไท และ เปาโล ดูรายละเอียดแพ็กเกจได้ที่ลิงก์นี้ : https://bit.ly/3heRQFS . Mission To The Moon x Phayathai & Paolo Hospitals #AllYouCanCheck  #PhyathaiHospital  #PaoloHospital #missiontothemoon #missiontothemoonpodcast

In this Ask Me Anything session, David and Peter discuss the latest age-reversal breakthroughs, getting approval from the FDA, and the possibility of living forever. You will learn about: 01:54 | Where are the breakthroughs & when are they coming? 06:46 | David Sinclair's experience dealing with the FDA 19:16 | How are David & Peter going to reduce aging? David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. He's been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents _____________ Resources Read David's book, Lifespan: Why We Age- and Why We Don't Have To Levels: Real-time feedback on how diet impacts your health. levels.link/peter  Consider a journey to optimize your body with LifeForce. Learn more about Abundance360. Read the Tech Blog. Learn more about Moonshots & Mindsets.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, David and Peter discuss aging as a disease, the technology needed to reverse aging, and tips and tricks to increase your lifespan. You will learn about: 01:27 | Is aging a disease? 18:20 | It's never too late to begin your Longevity Mindset 25:11 | How long until we reverse aging? 47:28 | Dietary changes to increase your health David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. He's been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents _____________ Resources Read David's book, Lifespan: Why We Age- and Why We Don't Have To Levels: Real-time feedback on how diet impacts your health. levels.link/peter  Consider a journey to optimize your body with LifeForce. Learn more about Abundance360. Read the Tech Blog. Learn more about Moonshots & Mindsets.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Durant cet épisode, je discute avec Maxime Mireault de balance occupationnelle, habitudes de vie, et de dépassement personnel. Si tu es une personne qui cherche à optimiser ta performance professionnelle - tu es au bon endroit parce que je te partage une conversation avec mon grand ami et ancien coéquipier, Maxime Mireault, qui va explorer l'équilibre fin de performance au travail et performance dans sa vie personnelle. Maxime partage sa biographie en début de conversation, alors je vais le laisser s'introduire soi-même… mais ce que je peux vous dire c'est que Maxime est excellent à faire des liens entre la vie de tous les jours et la performance professionnelle, c'est dans sa nature et dans sa personnalité puis on l'aime comme ça.  Pour rejoindre Maxime: maxime@ergolanaudiere.com Pour en connaitre plus sur ses services: https://www.ergolanaudiere.com/ Suivez Coach Frank sur TWITTER: https://twitter.com/coachfrankphd ABONNEZ-VOUS au podcast: https://drcoachfrank.com/contact/ NOTES D'ÉMISSION Introduction Maxime Mireault. (1:47) Ergothérapie Lanaudière clinique virtuelle. (6:10) Douleur chronique et l'intervention : « neuroscience pain ». (7:51) Étude fondamentale et étude clinique sur la douleur. (10:49) Profil évitant et profil modulant. (13:11) Coach Frank et Maxime parlent de leur sport ensemble et le « Spartan Race ». (18:10) Montrer l'exemple pour un top performer. (23:32) Le flow, balance récupération, travail sur l'ordinateur. (25:17) Livre de David Sinclair « Lifespan » (30:09) Balance occupationnelle. (33:36) Transitions majeures. (36:50) Les valeurs de Coach Frank, premièrement la santé. (38:33) Reconstruction cognitive. (43:46) Quelles sont les pliés de Maxime? (46:53) Profil persistant. (51:32) « Serial Winning Coaches ». (53:43) Zone de défi optimale. (59:44) Activité cognitive. (1:05:31) Notion du flow. (1:07:56) Le flow c'est une expérience dans laquelle on se perd. (1:13:36) Question : Si tu pouvais retourner en arrière et donner un conseil à toi-même, quand tu avais 23-24 ans, ça serait quoi? (1:14:30) Question : Pour Coach Frank, retourner en arrière à 2012, un conseil quand sa carrière a changé? (1:17:27) Mot de la fin. (1:21:02) PERSONNES ET ORGANISATIONS MENTIONNÉES Maxime Mireault (59) Maxime Mireault | LinkedIn Université d'Ottawa Accueil | Université d'Ottawa (uottawa.ca) Trail du Mont-Blanc [Ultra Trail du Mont-Blanc, 22 Aug 2022 | World's Marathons (worldsmarathons.com)](https://worldsmarathons.com/marathon/ultra-trail-du-mont-blanc-#:~:text=The Ultra-Trail du Mont-Blanc (also referred to as,a total elevation gain of around 9%2C600 m.) Pain neuroscience The Neuroscience of Pain | ICORD Ergo Lanaudière Accueil | Centre de thérapies et de réadaptation : Ergo Lanaudière (ergolanaudiere.com) Réseau québéquois des étudiants chercheurs sur la douleur QNJPI RQECD | RÉSEAU QUÉBÉCOIS DES CHERCHEURS JUNIORS SUR LA DOULEUR Lake Placid Spartan Race Lake Placid Trail Challenge - Spartan Trail David Sinclair « Lifespan »Lifespan: Why We Age―and Why We Don't Have To: Sinclair PhD, David A., LaPlante, Matthew D.: 9781501191978: Books - Amazon.ca

Telomere length is a recognized biomarker of aging and it plays an important role in longevity medicine. On today’s episode I have a renowned expert on telomere biology and longevity medicine, Dr. Joseph Raffaele, MD. Dr. Raffaele received his Bachelor of Arts in philosophy from Princeton University and his MD from Hahnemann University Medical School. He did his residency at The New York Hospital-Cornell University Medical Center. Dr. Raffaele is board certified in internal medicine, and is a diplomat of the American Board of Age Management Medicine. Dr. Raffaele is the co-founder and CEO of PhysioAge, a software analytic tool that enables next-generation medical consultations by comparing patient data to populations and optimal values to form a deeper understanding of the patients aging process. Their mission is to enhance the delivery of proactive medicine. Topics covered: What it means to practice longevity medicine Normal vs optimal results and the impact that has on our quality of life Improvement in GylcanAge/PhyscioAge scores when patients optimize their hormones The importance of estradiol for arterial health What is a telomere? How do you test the length of someones telomere? How do you improve the length of your telomere? What is TA-65? CMV virus and herpes virus Rapamycin This podcast is NOT medical advice. To check out Dr. Raffaele's PhysioAge software CLICK HERE To visit Dr. Raffaele's website CLICK HERE To purchase the book Lifespan: Why We Age―and Why We Don't Have To CLICK HERE Dr. Raffaele's INSTAGRAM Dr. Raffaele's TWITTER To reach Amy Stuttle for questions or comments please email podcast@amystuttle.cpm To visit Victory Men's Health webiste CLICK HERE Victory Men's Health INSTAGRAM Dr. Raffael's presentation on telomeres at A4M CLICK HERE Studies: Double-Blind, Placebo-Controlled, Randomized Clinical Trial Demonstrates Telomerase Activator TA-65 Decreases Immunosenescent CD8+CD28- T Cells in Humans What if there’s no such thing as “aging”? Rapamycin for longevity: opinion article Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease A natural product telomerase activator as part of a health maintenance program

Oxygen therapy to lengthen our telomeres and prolong the life of our chromosomes. Boosting the functioning of our mitochondria with NAD. Stem cell rejuvenation. These are just some of the exciting therapies that scientists are exploring in their quest to prevent the decline and suffering we experience as we age. But some scientists argue that these are just partial fixes and that the answer to the eternal quest for the fountain of youth lies in pinpointing the upstream driver of these hallmarks of ageing. They claim that thanks to breakthroughs in the science of genetics they have finally discovered the control system that generates the strength and health we associate with youth. It's the “epigenome”, which is the packaging that coils around our DNA and switches on and off the genes that shape the identity of our cells. They say that as we age this packaging unravels, which deregulates the DNA and cell information they have been safeguarding. Fix the packaging and we can completely reset our DNA and cells and regenerate our bodies so they are once again like brand new. Skeptics say that we need to look no farther than evolution to recognize that while ageing can be slowed down it can't be abolished. Despite the formidable powers of natural selection, a species that doesn't age and die has not emerged. This is because ageing is marked not just by cells that are slowing down but also by cells that are rapidly multiplying and becoming cancerous. It is impossible to fix one without the other benefiting, a form of intercell competition where human beings and our hopes of eradicating old age are the losers. Arguing for the motion is David Sinclair, Professor of Genetics at Harvard Medical School and one of TIME Magazine's “Top 50 people in health care”. He is the author of over 200 scientific papers as well as the New York Times bestseller Lifespan: Why We Age—and Why We Don't Have To. Arguing against the motion is Joanna Masel, Professor of Ecology & Evolutionary Biology at the University of Arizona. She is a mathematical modeller who has published over 50 papers in a variety of scientific fields and is the author of Bypass Wall Street: A Biologist's Guide to the Rat Race. Sources: ZNews, Fox News, WKTV Newschannel2, Science Time The host of the Munk Debates is Rudyard Griffiths - @rudyardg.   Tweet your comments about this episode to @munkdebate or comment on our Facebook page https://www.facebook.com/munkdebates/ To sign up for a weekly email reminder for this podcast, send an email to podcast@munkdebates.com.   To support civil and substantive debate on the big questions of the day, consider becoming a Munk Member at https://munkdebates.com/membership Members receive access to our 10+ year library of great debates in HD video, a free Munk Debates book, newsletter and ticketing privileges at our live events. This podcast is a project of the Munk Debates, a Canadian charitable organization dedicated to fostering civil and substantive public dialogue - https://munkdebates.com/ The Munk Debates podcast is produced by Antica, Canada's largest private audio production company - https://www.anticaproductions.com/   Executive Producer: Stuart Coxe, CEO Antica Productions Senior Producer: Christina Campbell Editor: Kieran Lynch Producer: Nicole Edwards Associate Producer: Abhi Raheja

John R. Miles - The Reverse Aging Effect: How to Stay Young and Healthy  | Brought to you by AppSumo (https://social.appsumo.com/passion) and Gusto  (https://www.gusto.com/passionstruck.) New research indicates that Ponce de Leon's much-hoped-for Fountain of Youth may be closer to reality than we imagined. And, that, my friends, is no science fiction. However, You don't have to imagine or hope for a mythical fountain of youth that holds the secret of reverse aging. You can decide daily to turn back the clock, slow the aging process, and reset your age.   --► Full show notes: https://passionstruck.com/the-reverse-aging-effect-stay-young-and-healthy/  --► Subscribe to My YouTube Channel Here: https://www.youtube.com/c/JohnRMiles --► Subscribe to the podcast: https://podcasts.apple.com/us/podcast/passion-struck-with-john-r-miles/id1553279283. *Our Patreon Page: https://www.patreon.com/passionstruck. Thank you for listening to this podcast. I hope you keep up with the weekly videos I post on the YouTube channel, subscribe to, and share your learnings with those who need to hear them. Your comments are my oxygen, so please take a second and say 'Hey' ;). Thank You To Our Sponsors: More Info At PassionStruck.Com/Deals Thank You, Gusto For Sponsoring. Gusto offers all-in-one payroll and HR for growing businesses. From full-service payroll and benefits to team management tools, Gusto makes it easy to support your hardworking team in one intuitive platform. Gusto is offering our listeners three months free: https://www.gusto.com/passionstruck. Thank You AppSumo For Sponsoring. Over 1 million entrepreneurs and creators trust AppSumo to help them discover, buy, and sell the products they need to grow their business and audience. As a special bonus, AppSumo is giving 10% off the already discounted price to the first 100 people who click the link in the show notes: https://social.appsumo.com/passion. Passion Struck Podcast Starter Packs New to the show? These Starter Packs are collections of our most popular episodes grouped by topic, and we now have them also on Spotify. You can also browse starter packs for existing listeners to find your old favorites. Every week, John interviews everyday heroes from all walks of life. Learn how to subscribe to the show and never miss a new episode and topic. What I discuss about the reverse aging effect: In this episode, I will discuss how we can intentionally slow down our biological aging process. Yes, you heard that right. Finding the core reason for aging and learning how diet, lifestyle choices, and exercise affect extending your life places the power of perspective and knowledge within your control. 0:00 Introduction and announcements 3:02 The quest for the fountain of youth 5:23 Why biological aging is influenced by our behavior 10:13 The science behind reverse aging 13:24 How Epigenetics and DNA Methylation impact reverse aging 16:16 Six secrets to reverse aging 23:04 Our future health is in our own hands 25:11 Analysis and future guest promo Show Links Show discussion questions: What is the history of the search for the fountain of youth? Why is reverse aging a hard topic for people to grasp? What were the key results of Ellen Langer's experience with the older men? What is the difference between chronological age and biological age? What other research has Dr. David Sinclair been involved with? What are your takeaways on epigenetics? How can you apply the six ways to reverse aging? What three things can you do to alter how you approach aging? What steps will you take after hearing today's episode to change your approach to how you are approaching your aging process? Interested in reading the transcript for the episode: https://johnrmiles.com/the-reverse-aging-effect-how-to-live-longer/  Lifespan: Why We Age and Why We Don't Have to By David Sinclair Ph.D.: https://amzn.to/3a1aaP7  Younger You: Reduce Your Bio Age And Live Longer, Better by Dr. Kara Firzgerald: https://amzn.to/3AgDYlf  My episode on why you should Why the Journey Is More Important Than the Destination: https://passionstruck.com/life-is-about-the-journey-not-the-destination/  My interview with Katy Milkman Ph.D. on how to create lasting behavior change: https://passionstruck.com/katy-milkman-behavior-change-for-good/  My interview with David Yaden Ph.D. on Self-Transcendence, Psychedelics, and Behavior Change: https://passionstruck.com/david-yaden-on-self-transcendence-experiences/  My interview with Elise Micheals on How Men Can Take Back their Power: https://passionstruck.com/elise-micheals-the-power-of-being-a-man/  My interview with Cathy Heller on How Do You Find Your Life's Passion: https://passionstruck.com/cathy-heller-how-do-you-find-your-lifes-passion/  Are you having trouble prioritizing yourself? I discuss the importance of self-love in Episode 104 Follow John on the Socials: * Twitter: https://twitter.com/Milesjohnr * Facebook: https://www.facebook.com/johnrmiles.c0m * Medium: https://medium.com/@JohnRMiles ​* Instagram: https://www.instagram.com/john_r_miles * LinkedIn: https://www.linkedin.com/in/milesjohn/ * Blog: https://johnrmiles.com * Instagram: https://www.instagram.com/passion_struck_podcast/ * Gear: https://www.zazzle.com/store/passion_struck/ -- John R Miles is a serial entrepreneur and the CEO and founder of Passion Struck. His full-service media company helps people live intentionally by creating best-in-class educational and entertainment content. John is also a prolific public speaker, venture capitalist, and author named to the ComputerWorld Top 100 IT Leaders.

This episode is based on the work of Dr. David Sinclair and his team. The book references is called Lifespan: Why We Age and Why We Don't Have to. Episode 3la syam: https://open.spotify.com/episode/7bAFut0AAvj185yE5591AQ Episode 3la Epigenetics: https://open.spotify.com/episode/2KRM1We9gsMAWlX31zWetY David Sinclair Podcast on Youtube: https://www.youtube.com/c/DavidSinclairPodcast

Venturing into entrepreneurship may seem like a far cry from the medical world and it's easy to feel scared when you're just getting started. What you need is an expert to guide and direct your steps, someone who knows the ins and outs, and most importantly, who knows that it is possible to achieve incredible success even in areas that are different from your field.  Chris Larsen joins Vikram to share from experience how the concept of arbitrage became a key factor that led him to achieve limitless wealth and success. Learn how this particular concept can be applied to every area of life and leads to unyielding results. If you're looking for strategies on how to amplify your life and take it to the next level, the formula you need is right here. “Understanding what our WHY is can make us think there's so much more we can do in life than what we think we're capable of.” - Chris Larsen In This Episode: - Welcome back to another episode of the Limitless MD podcast - Hear out the big WHY in the life of Chris Larsen  - Chris had an epiphany and this epiphany led him to make these kinds of decisions… - Here are the questions that Chris had to ask himself which led him to the path of financial abundance… - Study how the concept of arbitrage works and how to leverage it so you can take your income to the next level  - Learn the secret to having more money and more time freedom - Here are the two tangible reasons why it's okay to be selfish… - Find out why you need to be ruthless and the things that can be applied in all areas of life that define what can be done better - This is what people often forget about the real estate cycle… - Here are the things you need to know that can be really scary if you don't… - Realize the true essence of having joy in your life  - Here's the “one thing” that Chris wants to leave to the world as his lasting impact   Resources Mentioned: - https://www.nextlevelincome.com/next-level-income-show/ep-97-where-we-are-in-the-real-estate-cycle-with-dj-van-keuren (Where We Are In The Real Estate Cycle With DJ Van Keuren) - https://www.nextlevelincome.com/book (Get Your Free Book & Audiobook of The Next Level Income by Chris Larsen) - https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/1501191977 (Lifespan: Why We Age―and Why We Don't Have To by David Sinclair) - https://www.amazon.com/Secret-Life-Real-Estate-Banking/dp/0856832634 (The Secret Life of Real Estate and Banking by Phillip J. Anderson) - https://www.amazon.com/Who-Not-How-Accelerating-Teamwork-ebook/dp/B0867ZJ151 (Who Not How: The Formula to Achieve Bigger Goals Through Accelerating Teamwork by Dan Sullivan and Benjamin Hardy) - https://www.amazon.com/Gap-Gain-Achievers-Happiness-Confidence/dp/B09HN6GKNY/ref=sr_1_1?keywords=dan+sullivan&pd_rd_r=d7d2190c-1bfa-4d4d-bbfe-841ddfb70c62&pd_rd_w=3X3Ws&pd_rd_wg=7Na2L&pf_rd_p=2c083df3-a26e-4ea9-a512-e0aeb6fffdc2&pf_rd_r=0DAHTJ04GV6QJ5NBC6B5&qid=1651155874&sr=8-1 (The Gap and the Gain: The High Achievers' Guide to Happiness, Confidence, and Success by Dan Sullivan) Resources: - https://limitless-md.mn.co/ (Join our FREE group coaching program: the Physician Wealth Accelerator)- https://vikramraya.com/programs/ (https://vikramraya.com/programs/)  - https://vikramraya.com/ (Sign up to my email list) - Apply to work with Vik and book a clarity call https://www.theultramd.com/go?fbclid=IwAR1fp5TQt4aCSu_2EWu2sKZd3HumrHKOVePwFlPQC-2aYLgCAsm7_MHY69c (here)   Connect with Vikram: - https://vikramraya.com/ (Website) - https://www.instagram.com/vikramraya/ (Instagram) - https://www.facebook.com/Vikramrayamd (Facebook) - LinkedIn - https://www.youtube.com/channel/UCdq9M-kD0L2hy1UlfOK-hwQ (YouTube)  Connect with Chris Larsen: - https://www.nextlevelincome.com/ (Website) - https://www.linkedin.com/in/nextlevelincome/ (LinkedIn) - https://www.facebook.com/nextlevelincomeshow (Facebook) -...

Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it's never too late to slow the process of aging, and so much more.   Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He's been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To. -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish

Dr. Sinclair is a professor of genetics and co-director of Harvard Medical School's Center for Biology of Aging Research.    He is also the author of the great book Lifespan, why we age and why we don't have to and the host of the podcast Lifespan with Dr. David Sinclair that covers topics such as  the science behind why we age and interventions for slowing and even reversing aging.   Time Magazine has him as one of the 100 most influential people on earth and we packed so much incredible content into this podcast.    If you are interested in longevity, health, looking or feeling better and how to reduce ageing, this one is not to be missed.    Here are some of the things we talked about        What to eat and when to eat for longevity     Why fasting is hard for a few weeks and then it becomes considerably easier as your body gets used to it     The major misconceptions around aging     David's anti-aging regimen     Why aging is a disease and how that disease is treatable,     Anti-aging supplements to look into     Using exercise, heat and cold as acute stressors for longevity      His top seven tips for living a longer and younger life     And much more     Biological age test website:  Tallyhealth.com   His social   Facebook - https://www.facebook.com/davidsinclairphd Twitter - https://twitter.com/davidasinclair Instagram: https://www.instagram.com/davidsinclairphd/?hl=en Linkedin - https://www.linkedin.com/in/sinclairda/ Linktree: https://linktr.ee/lifespanbook   Youtube - https://www.youtube.com/davidsinclairpodcast     His website / Podcast   https://www.lifespanpodcast.com/  

A future in which we can pop pills to make us look and physically morph into being ten years younger… Well, according to biologist and Professor of Genetics, David Sinclair, it might not be as far-fetched as it sounds. In this episode of Brilliant Brains, Tim Samuels speaks to Dr David Sinclair about his groundbreaking book Lifespan: Why We Age - and Why We Don't Have To, why we need to view ageing as an illness, the implications of people routinely living into their 120s, and his daily regime for keeping ageing at bay.Brilliant Brains is a deep, deep - no holds - dive into the minds of some of the most fascinating thinkers out there.Find all the shows at karmacist.com/podcast. Music by Natureboy - remixed by Mudd. Hosted on Acast. See acast.com/privacy for more information.

InsideTracker is a truly personalized nutrition and performance system that can help you feel better, live longer, and maybe even figure out how to turn back the clock. Their mission is to help people add years to their lives and life to their years by optimizing their bodies from the inside out. By analyzing your body's data, they can give you a crystal clear picture of what's going on inside you along with a science-backed action plan for improving your health and becoming your best self. Before I found this system, I was searching for a way to know more about my current health. I also wanted to know how I could feel better, live a longer, healthier life, and be in my most optimal state of wellness. In this episode I share my personal experience using InsideTracker as a guide to better wellness, with an added perk: I'm getting younger too! Stay tuned for a coupon code to try InsideTracker for yourself this year! Check out InsideTracker.com and listen to the InsideTracker podcast, Longevity by Design with InsideTracker founder Dr. Gil Blander as well. In this episode I also mention Dr. David Sinclair and his book, Lifespan: Why We Age and Why We Don't Have To. Dr. Sinclair is one of the many scientists on InsideTracker's scientific advisory board. Just another reason why I'm impressed with what they do. Stay tuned for the special coupon code for 20% off your first order of any InsideTracker plan. --- Support this podcast: https://anchor.fm/plantfull/support

In this episode, I talk to world-renowned biologist David Sinclair about aging and longevity. David rejects the notion that the deterioration of health is a natural part of growing old and asserts that aging is a disease itself that we need to reverse. But how will a reset of our biological clocks affect our interactions, responses to adversity, morality, and how we live our lives? We discuss the ethical implications of limitless lifespans and also touch on the topics of death, evolution, genetics, medicine, and data tracking.BioDr. David Sinclair is a professor in the department of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and co-founder of the scientific journal Aging. He is best known for his work on understanding why we age and how to slow its effects. In addition to being a co-founder of several biotechnology companies, he's the author of the book Lifespan: Why We Age – and Why We Don't Have To. Dr. Sinclair was listed by TIME magazine as one of the “100 most influential people in the world”.Website: sinclair.hms.harvard.eduTwitter: @davidasinclair Topics00:02:26 David's “sticky beak” personality00:05:08 David's childhood and upbringing00:10:21 The torment of inevitable death 00:15:13 David's life purpose00:22:06 Intergenerational interactions 00:28:59 Aging is a disease we can reverse 00:32:20 Accelerating human evolution 00:36:24 The SIR2 gene and the NMN+ pill00:40:04 Reverse brain aging and Alzheimer's00:42:50 Gene therapy in pills00:48:45 Will we be happier with longer lifespans? 00:52:49 Inside Tracker00:55:31 The future of data tracking and medicine01:00:47 The Information Theory of Aging01:09:08 Is there a biological limit to our lifespans?01:14:21 Mental states can produce epigenetic changes01:20:39 David's future projects

As the saying goes, trust your gut — and this isn't only figuratively. One of the most overlooked aspects of health is our digestive system. We tend to ignore and underestimate the symptoms we experience around our gut. But with its link to our brains, our guts play a much more significant role in our overall health. The simple act of eating healthy foods can completely turn your life around. Kirsty Wirth joins us in this episode to share how reexamining gut health impacted her and her son's life. She talks about the road to recovery, specifically her family undergoing fecal microbial transplant (FMT). Kirsty highlights the importance of in-depth gut health testing, cutting out junk foods, and consuming healthy foods. She further discusses the two types of fermented food and how we can incorporate it into our diet. If you're having trouble with your digestive system and want to know which healthy foods to choose, this episode is for you.    Here are three reasons why you should listen to the full episode: Learn how an undiagnosed gut issue can lead to an autism spectrum misdiagnosis. Discover the importance of eating healthy foods when looking after your microbiome. Find out the two types of fermented food and their effects on the body.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new program, BOOSTCAMP, is coming this September at Peak Wellness!  Listen to my other Pushing the Limits episodes:  #170: The Search for the Perfect Protein and Why So Many of Us Are Deficient with Dr David Minkoff #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Kirsty: Instagram I Facebook I Email  Kultured Wellness Get your Kultured Wellness starter culture here! Join a Kultured Wellness Programme today! Kulturing Kuriosity podcast Lifespan: Why We Age – and Why We Don't Have To by Dr David Sinclair   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third-party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [04:55] The Story Behind Kultured Wellness Kirsty started Kultured Wellness because of her personal experience and what her son went through.  She started having tummy upsets from age two onwards. She would constantly swing between constipation and diarrhea.  Acquiring viral encephalitis at age 13 and being hospitalised for a week was a landmark time in Kirsty's life. Gut problems became a constant issue from then on. Her husband, who is a nurse, told her constant diarrhea is not normal. So, she dabbled with various diets but didn't stick with them. It's not until they found out about her son's conditions that Kirsty took concrete action. [09:55] Kirsty's Son's Autism Spectrum Diagnosis At 13 months, Noah suffered from infections and tummy troubles. Fortunately, his recovery progressed well. But at 18 months, Noah became completely non-verbal, underwent behavioural changes, and suffered from constant diarrhea. The paediatrician said that Noah's condition was normal. However, his condition only worsened.  Then, Noah was diagnosed with autism. This gave them funding for treatment and support. [13:56] Discovery of an Underlying Gut Issue The possibility that Kirsty passed on her diarrhea issue to Noah was always at the back of her mind. They found a doctor who listened to their suspicion that Noah has an underlying condition.  After testing Noah's stool sample, they discovered that he had Clostridium difficile, a type of antibiotic-resistant bacteria. This bacteria releases endotoxin that compromises the gut and the blood-brain barrier. They found that the endotoxin in Noah's body had attached to the brain receptors responsible for socialisation and learning. [17:21] Undergoing Fecal Microbial Transplant (FMT) Kirsty and her two children participated in a research study in Canada. There, they underwent a fecal microbial transplant. Their guts were flushed with antibiotics to get rid of everything, including the Clostridium difficile. These were then replaced with donors' microbes.  Kirsty's children were the youngest people to undergo FMT. While they were there, Noah started becoming more sociable. Not everyone needs to undergo FMT to recover their gut. There are now many ways to modulate the gut, one of which is eating healthy foods. Tune in to the full episode to hear more about Noah's recovery and development as a teen! [25:42] Getting Diagnosed with PANDAS PANDAS is an autoimmune neurological condition associated with an antigen. Both Kirsty and Noah got diagnosed with it. It stands for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. Listen to the full podcast to learn more about PANDAS and how Kirsty acquired it! [33:13] Looking After Your Microbiome Test, don't guess. Get a comprehensive stool analysis. Kirsty uses two tests for her clients. You need to be intentional in choosing healthy foods. Include fermented and nourishing food for your gut. Also, remember that diets do not work. No amount of willpower can go against our primal built-in set point. [46:10] Two Types of Fermented Food and Their Effect on the Body The first is the wild type. This includes histamine-forming foods or lactate-forming metabolites. Our gut has microbes that consume histamine and help us not develop histamine issues. The second is uncultured ferment. These are specific ferments in a controlled environment with specifically chosen strains. People struggling with lactate-forming metabolites should choose D-lactate bacteria strains.  These strains break down and down-regulate histamines without causing reactions. [48:50] Incorporating Fermented Healthy Foods into Your Diet You can start with small amounts of uncultured ferment to build out your microbiome.  Then, you can start dabbling with wild ferments. Kirsty develops cultures with nine different strains that have efficacy for autoimmune, neurological, and digestive conditions. Kultured Wellness offers a starter culture that you make yourself. Listen to the full episode to know the ingredients and the procedure! [53:05] On Probiotics and Digestive Enzymes One capsule of probiotics in the market has around 3 million CFU or colony-forming units.  Meanwhile, a cup of Kultured Wellness yoghurt has 41 billion CFU. The absence of digestive enzymes and stomach acid is a major problem today. Fermented food helps with this problem because it has already been pre-digested from the fermenting process.  Fermented food doesn't require a robust amount of digestive enzymes. In fact, it supports the excretion of stomach acid. [57:06] Parting Advice  Be curious and try your best to connect with your body. You're in a state of fight or flight all the time when you're unwell. We should not be focusing on DNA; it's the microbes that affect our DNA. Being curious, taking responsibility, owning it, and wanting more for yourself is crucial.   7 Powerful Quotes ‘I have seen how important your gut is and how it can completely change the pathway of your life. It can completely change who you are as a person.' ‘You don't just suddenly wake up one day and you've got cognition issues; that's coming from somewhere.' ‘So the first thing is just test, don't guess... We [can] really find out what is happening in our gut, and we can find out what it is doing to the rest of our body.' ‘If you want to make change, you've got to front up to make the change.' ‘If they don't include fermented foods and they don't include nourishing foods for their gut, they're relying on willpower. No one can get anywhere with willpower.' ‘It's what everyone finds hard and doesn't know, is that you should never rely on willpower. Diets will never work.' ‘DNA is not what we should be focusing on. It's actually the microbes and those fungi and viruses that make up our whole body that actually interacts through that.'   About Kirsty Kirsty Wirth is the founder of Kultured Wellness and an expert in cultures, gut health, and probiotics. Kultured Wellness is a company dedicated to providing knowledge and healthy foods for optimum gut health. As an integrative health coach, Kirsty's area of interest is in how lifestyle, environment, and diet can impact gut health and the immune system. Drawing on her background and years of research, Kirsty educates people on the root cause behind underlying conditions. Her mission is to spread the word about the benefits of healthy foods, particularly fermented food in nourishing the gut's microbiome. If you want to learn more about Kultured Wellness, you may visit their website. You can reach out to Kirsty on Instagram and Facebook. You can also send her an email at mailto:info@kulturedwellness.com.     Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can be inspired to eat healthy foods for their gut health.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

David Sinclair (biologist, Professor of Genetics at Harvard Medical School, and author of Lifespan: Why We Age and Why We Don't Have To) discusses ways we can extend our lifespan and the work he's doing to slow and reverse aging brain cells. He details the best lifestyle changes and emerging technologies available now to prevent most diseases until our 80's, increase longevity, and even reverse the effects of aging. David opens up about his mental health struggles stemming from his own insecurities and frustrations with the planet, how his mother's passing changed his outlook on life, and the dream he had that influenced his research and became a turning point in his career. After debating about intermittent fasting, Mayim and David examine the thread between solving problems in medicine, economics, and sociology, the effects of stress on the aging process, and mental health components tied to the aging brain. Mayim considers the amount of resources needed if humans lived longer, and the impact western culture's attitude about aging might have on an increased lifespan.David Sinclair's Book: https://lifespanbook.com/?utm_medium=social&utm_source=linktress&utm_campaign=get%20the%20book

This book takes us to the frontlines of research many from Dr David Sinclair's own lab at Harvard—that demonstrate how we can slow down, or even reverse, ageing. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of ageing and the key to reversing it.

I am delighted to have Dr. Gil Blander, an internationally recognized anti-aging researcher, joining me on the show today! Gil has a background in the basic biology of aging and translating his discoveries into new ways of detecting and preventing age-related conditions. He received a Ph.D. in biology from the Weizmann Institute of Science and completed his postdoctoral fellowship at MIT. He has been featured In CNN Money, The New York Times, Forbes, The Financial Times, and The Boston Globe. There are many connections between Gil's childhood in Israel and his quest for longevity. One of his relatives passed away when he was twelve years old. When that happened, Gil realized that he would not live forever. It worried him, and that concern stimulated his interest in longevity and aging and prompted him to study biology, do a Ph.D. at the Weizmann Institute of Science, spend five years at MIT in the best lab to study aging, and found InsideTracker. Listen in today to find out all you need to know about the lifestyle choices that will promote anti-aging and longevity. IN THIS EPISODE YOU WILL LEARN Gil shares his background. What prompted Gil to leave the lab at MIT to go into the private sector. How and why caloric restriction extends our lifespan. How Gil transitioned from academia into the private sector. Gil explains what happens in the body when calories are restricted. How Gil managed to find the best blood biomarkers for longevity,   performance, and wellness. How Gil found the interventions to optimize anti-aging blood biomarkers. How nutrition and lifestyle changes can aid longevity. How the InsideTracker process works, and why it utilizes blood rather than saliva or urine for the testing. Gill talks about bio-individuality and clarifies some of the confusion often associated with epigenetic testing. Foods that promote or prevent longevity. The lifestyle choices that are essential for anti-aging and longevity. Gil talks about supplements. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia's website  Connect with Gil Blander (InsideTracker) On the website On Facebook, Instagram, LinkedIn,   and Twitter Book mentioned: Lifespan: Why We Age―and Why We Don't Have To  by Dr. David Sinclair

What if I told you that there's a way to keep yourself young? It takes a lot of hard work, and it's a continuing process. However, the payoff is definitely worth it. It also offers a lot of benefits aside from longevity. The secret? It's developing a lifelong passion for learning and growing. In this episode, Craig Harper joins us once again to explain the value of having a growth mindset. We explore how you can keep yourself young and healthy even as you chronologically age. He also emphasises the importance of fun and laughter in our lives. Craig also shares how powerful our minds are and how we can use them to manage our pain.    If you want to know how to develop a growth mindset for a fuller life, then this episode is for you!   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or are wanting to take your performance to the next level and learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third-party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Here are three reasons why you should listen to the full episode: Learn how to develop a growth mindset to keep yourself young and healthy, regardless of your chronological age. Understand why you need to manage your energy and plan fun and laughter into your life. Discover the ways you can change your mindset around pain.    Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Listen to other Pushing the Limits Episodes: #60: Ian Walker - Paraplegic Handbiker - Ultra Distance Athlete #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #188: Awareness and Achieve High Performance with Craig Harper  #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Craig: Website | Instagram | Linkedin Interested to learn more from Craig? You can check out his books and his podcast, The You Project. T: The Story of Testosterone by Carole Hooven  Mind Over Medicine by Lissa Rankin M.D. Lifespan - Why We Age and Why We Don't Have To  by David A. Sinclair PhD Neuroscience professor Andrew Huberman's Instagram  Dr Rhonda Patrick's website A new program, BoostCamp, is coming this September at Peak Wellness!   Episode Highlights [06:50] A Growth Mindset Keeps Us Young and Healthy It's helpful to take advantage of the availability of high-level research and medical journals online. If you're prepared to do the hard work, you can learn anything.  Learning and exposing ourselves to new things are crucial parts of staying young and healthy.  Age is a self-created story.  With a growth mindset, you can change how your body and mind works so that you feel younger than your real age.  [12:23] Develop a Growth Mindset It's vital to surround yourself with people with the same mindset — people who drag you up, not down.  You can also get a similar experience by exposing yourself to good ideas and stories. Be aware of what you're feeding your mind, on top of what you're feeding your body.  School is not a marker of your intelligence. Your academic failures do not matter.  With a growth mindset, you can keep growing and learning.  [17:40] Let Go and Be Happy People tend to have career and exercise plans, but not a fun plan.  We can't be serious all the time — we also need time to have fun and laugh.  Laughter can impact and improve the immune system. Laughing can change the biochemistry of your brain. Plan for the future, but also learn to live in the now. Having a growth mindset is important, but so is finding joy and enjoyment.  [23:31] Look After Your Energy Having fun and resting can impact your energy and emotional system.  These habits can help you work faster than when you're just working all the time.  Remember, volume and quality of work are different.  [30:24] Work-Life Balance Many people believe that they need to balance work and life. However, when you find your passion, it's just life.  Even doing 20 hours of work for a job you hate is worse than 40 hours of doing something you love. There's no one answer for everyone. Everything is a lot more flexible than before. Find what works for you.  [35:56] Change the Way You Think It's unavoidable that we think a certain way because of our upbringing.  Start to become aware of your lack of awareness and your programming.  Learn why you think of things the way you do. Is it because of other people?  Be influenced by other people, but test their ideas through trial and error. Let curiosity fuel your growth mindset.  Listen to the full podcast to learn how Craig learned how to run his gym without a business background!  [44:18] Sharing Academic Knowledge Academics face many restrictions due to the nature and context of their work.  He encourages the academic community to communicate information to everyone, not just to fellow researchers.  He plans to publish a book about his PhD research to share what he knows with the public. Science is constantly changing. We need to keep up with the latest knowledge.   [50:55] Change Your Relationship with Pain There is no simple fix to chronic pain.  The most you can do is change your relationship and perception of pain.  Our minds are powerful enough to create real pain even without any physical injury. Listen to Craig and Lisa's stories about how our minds affect our pain in the full episode!   7 Powerful Quotes from This Episode ‘My mind is the CEO of my life. So I need to make sure that as much as I can, that I'm managing my mind, and my mental energy optimally.' ‘If you're listening to this, and you didn't succeed in the school system, that means absolutely nothing when you're an adult.' ‘We're literally doing our biology good by laughing.' ‘Living is a present tense verb, you can't living in the future, and you can't live in the future.' ‘Often, more is not better. Sometimes more is worse.  So there's a difference between volume of work and output and quality of work.' ‘It's all about those people just taking one step at a time to move forward... That growth mindset that I think is just absolutely crucial.'   About Craig Craig Harper is one of Australia's leading educators, speakers, and writers in health and self-development. He has been an integral part of the Australian health and fitness industry since 1982. In 1990, he established a successful Harper's Personal Training, which evolved into one of the most successful businesses of its kind.  He currently hosts a successful Podcast called 'The You Project'. He is also completing a neuropsychology PhD, studying the spectrum of human thinking and behaviour. Craig speaks on various radio stations around Australia weekly. He currently fills an on-air role as a presenter on a lifestyle show called 'Get a Life', airing on Foxtel.  Want to know more about Craig and his work? Check out his website, or follow him on Instagram and Linkedin!   Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn how to develop a growth mindset. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa   Full Transcript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Well, hi everyone and welcome back to Pushing the Limits with Lisa Tamati. This week I have Craig Harper. He is really well known in Australia. He's a broadcaster, a fitness professional, a PhD scholar, an expert on metacognition, and self-awareness. And we get talking on all those good topics today and also neuro-psycho-immunology, very big word. Really interesting stuff; and we get talking about laughter, we get talking about pain management. We sort of go all over the show in this episode, which I sometimes do on this show. I hope you enjoy this very insightful and deep conversation with Craig Harper.  Before we head over to the show, I just want to let you know that Neil and I at Running Hot Coaching have launched a new program called Boost Camp. Now, this will be starting on the first of September and we're taking registrations now. This is a live eight-week program, where you'll basically boost your life. That's why it's called Boost Camp. not boot camp, Boost Camp. This is all about upgrading your body, learning how to help your body function at its base, learning how your mindset works, and increasing your performance, your health, your well-being and how to energise your mind and your body. In this Boost Camp, we're going to give you the answers you need in a simple, easy-to-follow process using holistic diagnostic tools and looking at the complete picture.  So you're going to go on a personalised health and fitness journey that will have a really life-changing effect on your family and your community. We're going to be talking about things like routine and resilience, mental resilience, which is a big thing that I love to talk about, and how important is in this time of change, in this time of COVID, where everything's upside down, and how we should be all building time and resources around building our resilience and energising our mind and body. We're going to give you a lot of health fundamentals. Because the fundamentals are something simple and easy to do, it means that you probably aren't doing some of the basics right, and we want to help you get there.  We're going to give you the answers you need in a simple, sort of easy, process. So we are now in a position to be able to control and manage all of these stressors and these things that are coming at us all the time, and we want to help you do that in the most optimal manner. So check out what boost camp is all about. Go to www.peakwellness.co.nz/boostcamp. I'll say that again, peakwellness.co.nz/boostcamp, boost with a B-O-O-S-T, boost camp. We hope to see you over there! Right, now over to the show with Craig Harper. Well, hi everyone and welcome to Pushing the Limits! Today, I have someone who is a special treat for you who has been on the show before. He's an absolute legend, and I love him to bits. Craig half and welcome to the show mate, how are you doing?  Craig Harper: Hi Lisa! I'm awesome but you're not.  Lisa: No I'm a bit of a miss, people. I've got shingles, a horrible, horrible virus that I advise nobody to get. Craig: What it— do we know what that's made? What causes it, or is it idiopathic as they say? Lisa: Yeah, no, it is from the chickenpox virus. Although, I've never, ever had that virus. So I'm like heck how, you know, it's related to the cold sore virus and all of that, which I definitely have had often. So it sits on the spinal cord, these little viruses, dormant and then one day when your immune systems are down, it decides to attack and replicate and go hard out. So yeah, that'll be the down for the count now for two and a half weeks. In a lot of pain, but— Craig: What is it like nerve pain or what kind of pain is it?  Lisa: Yes, it's nerve pain. So this one's actually, it hits different nerves in different people, depending on where it decides to pop out. My mum had the femoral nerve, which is one that goes right down from the backbone, quite high up on the backbone, down across the back and then down through the hip flexor and down the leg. I've got all these horrible looking sores, I look like a burn victim all the way down my leg and across my back. And it comes out through the muscles of your like, through the nerves and nerve endings and causes these blisters on top of the skin but it's the nerve pain that's really horrible because there's no comfortable position. There's no easy way to lie or sit and of course, when you're lying at night, it's worse. It's worse at nighttime than in the day. So I learned a lot about shingles. And as usual, we're using these obstacles to be a learning curve. Craig: Why on earth are you doing a bloody podcast? You should be relaxing. Lisa: You're important, you see. I had, you know, I had this appointment with you, and I honour my appointments, and I— Craig: Definitely not important. What's the typical treatment for shingles? Lisa: Well, actually, I wish I'd known this two weeks ago, I didn't know this, but I just had a Zoom call with Dave Asprey, you know, of Bulletproof fame, who is one of my heroes, and he's coming on the show, people, shortly. So that's really exciting. He told me to take something called BHT, butylated hydroxytoluene, which is a synthetic antioxidant. They actually use them in food additives, they said that kills that virus. So I'm like, ‘Right, get me some of that.' But unfortunately, I was already, it's— I only got it just yesterday, because I had to wait for the post. So I'm sort of hoping for a miracle in the next 24 hours.  Also, intravenous vitamin C, I've had three of those on lysine, which also helps. One of the funny things, before we get to the actual topic of the day, is I was taking something called L-Citrulline which helps with nitric oxide production and feeds into the arginine pathway. Apparently, while that's a good thing for most people, the arginine, if you have too much arginine in the body, it can lead to replication of this particular virus, which is really random and I only found that out after the fact. But you know, as a biohacker, who experiments sometimes you get it wrong.  Craig: Sometimes you turn left when you should have turned right.  Lisa: Yes. So that, you know, certainly took a lot of digging in PubMed to find that connection. But I think that's maybe what actually set it off. That combined with a pretty stressful life of like— Craig: It's interesting that you mentioned PubMed because like a lot of people now, you know how people warn people off going Dr Google, you know, whatever, right. But the funny thing is, you can forget Dr Google, I mean, Google's okay. But you can access medical journals, high level— I mean, all of the research journals that I access for my PhD are online. You can literally pretty much access any information you want. We're not talking about anecdotal evidence, and we're not talking about theories and ideas and random kind of junk. We're talking about the highest level research, you literally can find at home now. So if you know how to research and you know what you're looking for, and you can be bothered reading arduous academic papers, you can pretty much learn anything, to any level, if you're prepared to do the work and you know how— and you can be a little bit of a detective, a scientific detective.  Lisa: That is exactly, you know, what I keep saying, and I'm glad you said that because you are a PhD scholar and you are doing this. So you know what you're talking about, and this is exactly what I've done in the last five years, is do deep research and all this sort of stuff. People think that you have to go to university in order to have this education, and that used to be the case. It is no longer the case. We don't have to be actually in medical school to get access to medical texts anymore, which used to be the way. And so we now have the power in our hands to take, to some degree, control over what we're learning and where we're going with this.  It doesn't mean that it's easy. You will know, sifting through PubMed, and all these scholarly Google articles and things in clinical studies is pretty damn confusing sometimes and arduous. But once you get used to that form of learning, you start to be able to sift through relatively fast, and you can really educate yourself. I think having that growth mindset, I mean, you and I never came from an academic background. But thanks to you, I'm actually going to see Prof Schofield next week. Prof Schofield and looking at a PhD, because, I really need to add that to my load. But— Craig: You know, the thing is, I think in general, and I don't know where you're gonna go today, but I think in general, like what one of the things that keeps us young is learning and exposing ourselves, our mind and our emotions and for that matter, our body to new things, whether that's new experiences or new ideas, or new information, or new environments, or new people. This is what floats my boat and it keeps me hungry and it keeps me healthy physically, mentally, emotionally, intellectually, creatively, sociologically. It keeps me healthy. Not only does it keep me in a good place, I'm actually at 57, still getting better. You know, and people might wonder about that sometimes.  Of course, there's an inevitability to chronological aging. Clearly, most people at 80 are not going to be anything like they were at 40. Not that I'm 80. But there's— we know now that there's the unavoidable consistency of time as a construct, as an objective construct. But then there's the way that we behave around and relate to time. Biological aging is not chronological aging. In the middle of the inevitability of time ticking over is, which is an objective thing, there's the subject of human in the middle of it, who can do what he or she wants. So, in other words, a 57-year-old bloke doesn't need to look or feel or function or think like a 57-year-old bloke, right?  When we understand that, in many ways, especially as an experience, age is a self-created story for many people. I mean, you've met, I've met and our listeners have met 45-year-olds that seem 70 and 70-year-olds— and we're not talking about acting young, that's not what we're talking about. I'm not talking about that. I'm not talking about pretending you're not old or acting young. I'm actually talking about changing the way that your body and your mind and your brain and your emotional system works, literally. So that you are literally in terms of function, similar to somebody or a ‘typical' person who's 20 or 25 years younger than you. We didn't even know that this used to be possible, but not only is it possible, if you do certain things, it's very likely that that's the outcome you'll create. Lisa: Yeah, and if you think about our grandparents, and when I think about my Nana at 45 or 50, they were old. When I think about now I'm 52, you're 57, we're going forward, we're actually reaching the peak of our intellectual, well, hopefully not the peak, we're still going up. Physically, we got a few wrinkles and a few grey hairs coming. But even on that front, there is so much what's happening in the longevity space that my take on it is, if I can keep my shit together for the next 10 years, stuff's gonna come online that's gonna help me keep it on for another 20, 30, 40 years.  For me now it's trying to hold my body together as best I can so that when the technology does come, that we are able to meet— and we're accessing some of the stuff now, I mean, I'm taking some of the latest and greatest bloody supplements and biohacking stuff, and actively working towards that, and having this, I think it's a growth mindset. I had Dr Demartini on the show last week, who I love. I think he's an incredible man. His mindset, I mean, he's what nearly, I think he's nearly 70. It looks like he's 40. He's amazing. And his mind is so sharp and so fast it'll leave you and I in the dust. He's processing books every day, like, you know, more than a book a day and thinking his mind through and he's distilling it and he's remembering, and he's retaining it, and he's giving it to the world. This is sort of— you know, he's nothing exceptional. He had learning disabilities, for goodness sake, he had a speech impediment, he couldn't read until he was an adult. In other words, he made that happen. You and I, you know, we both did you know, where you went to university, at least when you're younger, I sort of mucked around on a bicycle for a few years. Travelling the world to see it. But this is the beauty of the time that we live in, and we have access to all this. So that growth mindset, I think keeps you younger, both physically and mentally. Craig: And this is why I reckon it's really important that we hang around with people who drag us up, not down. And that could be you know, this listening to your podcast, of course, like I feel like when I listen to a podcast with somebody like you that shares good ideas and good information and good energy and is a good person, like if I'm walking around, I've literally got my headphones here because I just walked back from the cafe, listening to Joe Rogan's latest podcast with this lady from Harvard talking about testosterone, you'd find it really interesting, wrote a book called T.  When I'm listening to good conversations with good people, I am, one, I'm fascinated and interested, but I'm stimulating myself and my mind in a good way. I'm dragging myself up by exposing myself to good ideas and good thinking, and good stories. Or it might even be just something that's funny, it might— I'm just exposing myself to a couple of dickheads talking about funny shit, right? And I'd spend an hour laughing, which is also therapeutic.  You know, and I think there's that, I think we forget that we're always feeding our mind and our brain something. It's just having more awareness of what am I actually plugging into that amazing thing? Not only just what am I putting in my body, which, of course, is paramount. But what am I putting in, you know, that thing that sits between my ears that literally drives my life? That's my HQ, that's my, my mind is the CEO of my life. So I need to make sure that as much as I can, that I'm managing my mind and my mental energy                                                                                  optimally. Lisa: Yeah. And I think, you know, a lot of people if they didn't do well in the school system, think that, 'Oh, well, I'm not academic therefore I can't learn or continue to learn.' I really encourage people, if you're listening to this, and you didn't succeed in the school system, that means absolutely nothing when you're an adult. The school system has got many flaws, and it didn't cater to everybody. So I just want people to understand that.  You know, just like with Dr Demartini, he taught himself 30 words a day, that's where he started: vocabulary. He taught himself to read and then taught— Albert Einstein was another one, you know, he struggled in school for crying out loud. So school isn't necessarily the marker of whether you're an intelligent human being or not. It's one system and one way of learning that is okay for the average and the masses. But definitely, it leaves a lot of people thinking that they're dumb when they're not dumb.  It's all about those people just taking one step at a time to move forward and becoming, you know, that growth mindset that I think is just absolutely crucial. You talked there about laughter and I wanted to go into that a little bit today too, because I heard you talking on Tiffany, our friend Tiffany's podcast, and you were talking about how important laughter is for the body, for our minds, for our— and if we laugh a lot, we're less likely to fall victim to the whole adult way of being, which is sometimes pretty cynical and miserable. When you think, what is it? Kids laugh something like 70 times a day and adults laugh I think, six times a day or some statistic. Do you want to elaborate on that a little bit? Craig: Well, I used to sit down with you know, I don't do much one-on-one coaching anymore, just because I do other stuff. I would sit with people and go, ‘Alright, tell me about your exercise plan and blah, blah, blah. Tell me about your career plan, blah, blah, blah. Tell me about your financial plan, blah, blah, blah.' Tell me about, you know, whatever. And they have systems and programs and plans for everything.  I would say to them, 'Do you like fun?' And they're like, they look at me like I was a weirdo. 'What do you mean?' I go, 'Well, what do you mean, what do I mean? Like, do you like having fun?' And they're like, very seriously, like, 'Well, of course, everyone likes having fun.' I go, 'Great. What's your fun plan?' And they go, 'What?' I go, 'What's your fun— like, is laughing and having fun important to you?' 'Yeah, yeah.' 'Okay, what's your fun plan?'  They literally, like this idea of just integrating things into my life, which are for no reason other than to laugh and to have fun. Not to be productive and efficient and to tick more boxes and create more income and elevate output and tick fucking boxes and hit KPIs and you know, just to be silly, just to laugh like a dickhead, just to hang out with your mates or your girlfriends, or whatever it is. Just to talk shit, just to, not everything needs to be fucking deep and meaningful and world-changing. Not everything. In fact, it can't, you know?  Our brain and our body and our emotional system and our nervous system and— it can't work like that we can't be elevated all the time. And so, literally when we are laughing, we're changing the biochemistry of our brain. You know, literally when we are having fun, we're impacting our immune system in a real way through that thing I've probably spoken to you about, psychoneuroimmunology, right? We're literally doing our biology good by laughing and there's got to be, for me, there's got to be, because, like you probably, I have a lot of deep and meaningful conversations with people about hard shit. Like, I'm pretty much a specialist at hard conversations. It's what I do. But, you know, and, and I work a lot, and I study a lot. Then there needs to be a valve. You can't be all of that all of the time because you're human, you're not a cyborg, you're not a robot. And this hustle, hustle, hustle, grind, work harder, sleep less, you can, you know, you can sleep when you're dead, it's all bullshit. Because, also, yeah, I want to learn and grow and evolve, and I want to develop new skills. But you know what, I want to also, in the moment, laugh at silly shit. I want to be happy and I want to hang out with people I love and I want to be mentally and emotionally and spiritually nourished.  Like, it's not just about acquiring knowledge and accumulating shit that you're probably not going to use. It's also about the human experience now. This almost sounds contradictory. But because of course, we want a future plan and we want goals and all of those, but we're never going to live in the present because when we get there, it's not the present. It's just another installment of now. So when next Wednesday comes, it's not the future, it's now again, because life is never-ending now, right?  It's like you only like, live— living is a present tense verb. You can't living in the future, and you can't live in the future. You cannot. Yes, I know, this gets a little bit, what's the word existential, but the truth is that, yeah, we need to— well, we don't, we can do whatever we want. But I believe we need to be stimulated so we're learning and growing, and we're doing good stuff for our brain and good stuff for our body. But also that we are giving ourselves a metaphoric hug, and going, 'It's all right to lie on your bed and watch Netflix, as long as it's not 20 hours a day, five days a week,' you know. It's okay to just laugh at silly stuff. It's okay, that there's no purpose to doing this thing other than just joy and enjoyment, you know.  I think that people like you and me who are, maybe we would put ourselves in the kind of driven category, right? You and I are no good at this. Like, at times, having fun and just going, ‘I'm going to do fuck all today.' Because the moment that we do sometimes we start to feel guilty and we start to be like, 'Fuck, I'm not being productive. I've got to be productive.' That, in itself, is a problem for high performance. Like, fuck your high performance, and fuck your productivity today. Be unproductive, be inefficient, and just fucking enjoy it, you know, not— because in a minute, we're going to be dead. We're going to go, 'But fuck, I was productive. But I had no fun, I never laughed, because I was too busy being important.' Fuck all that. Lisa: I think both of us have probably come a long way around finding that out. I mean, I used to love reading fiction novels, and then I went, ‘Oh, I can't be reading fiction novels. I've got so many science books that I have to read.' Here I am, dealing with insomnia at two o'clock in the morning reading texts on nitric oxide, you know. It is this argument that goes on, still in my head if there was an hour where you weren't learning something, you know, I can't. Because I know that if I go for a big drive or something, and I have to travel somewhere, or going for a long run or something, I've probably digested a book on that road trip or three, or 10 podcasts or something and I've actually oh, I get to the end and I'm like, ‘Well, I achieved something.' I've got my little dopamine hits all the way through.  Now I've sort of come to also understand that you need this time out and you need to just have fun. I'm married to this absolute lunatic of a guy called Haisely O'Leary, who I just love, because all day every day, he is just being an idiot. In the best sense of the word. I come out and I'm grumpy and you know, had a hard day and I'm tired, I'm stressed, and I come out and he's doing a little dance, doing some stupid meme or saying some ridiculous thing to me. I'm just like, you know, I crack up at it. That's the best person to have to be around because they keep being—and I'm like, ‘Come on, stop being stupid, you should be doing this and you shouldn't be doing that.' Then I hear myself, and I'm like, ‘No, he's got it right.' Craig: Well, I think he does, in some ways, you know. It's not about all, it's not about one or the other, it's about— and it's recognising that if I look after my energy, and my emotional system, and all of that, I'll get more done in 8 hours than 12 hours when I'm not looking after myself. So more is not better, necessarily. In fact, often, more is not better; sometimes, more is worse. So there's a difference between volume of work and output and quality of work. Also, you know, quality of experience.  I wrote a little thing yesterday, just talking on social media about the fact that I, like all of the things that I do, even study, although it's demanding, but I enjoy it. My job, you know, like, right now you and I do podcasts. I do seven podcasts a week, apart from the ones like this, where I'm being interviewed by someone else, or spoken to by somebody else. My life is somewhat chaotic, but I don't really, in terms of having a ‘job'. Well, one, I don't have a job. I haven't had a job since I was 26. Two, I don't really feel a sense of work, like most people do.  Like the other night, I did a gig. I don't know if you, if I posted a little thing about this on Insta, and I was doing a talk for Hewlett Packard in Spain. Now, how cool is the world? Right? So I'm talking here, right here in my house, you can see, obviously, your listeners can't. But this is not video, is it? Just us? I wish I knew that earlier. Sorry, everyone, I would have brushed my hair. But anyway, you should see my hair by the way. I look like bloody Doc from Back to the Future. Anyway, but I'm sitting in here, I'm sitting in the studio, and I'm about to talk to a few hundred people in Spain, right, which is where, that's where they're all— that's where I was dealing with the people who are organising me to speak.  Just before I'm about to go live at 5:30, the lady who had organised me was texting me. So it's on Zoom. There's already a guy on the screen speaking and then lots of little squares of other humans. I said to her, ‘How many?' and said, ‘You know, like a few 100.' I said, ‘Cool.' I go, ‘Everyone's in Spain,' and she goes, ‘No, no, we're in Spain, but the audience is around the world.' And I go, ‘Really? How many countries?' She goes, ‘38.' I'm sitting here and I'm thinking, I'm wearing a black t-shirt. I'm wearing my camo shorts. I've got bare feet. I'm talking to hundreds of humans from this big organisation in 38 countries, and I'm talking about the stuff that I am passionate about, right? I don't have to do any prep, because it's my default setting. I'm just talking. I had to talk for an hour and a half about high performance. Well, giddy up, that's like an hour and a half of breathing. You know?  I just had such fun, and I had this moment, Lisa, halfway through, I don't know, but about halfway through, where I'm like, I remember growing up in a paradigm where pretty much when I was a kid everyone went and got a job and you went, you became a cop or you sold clothes, or you're a bricky or sparky or you're some kind of tradie. A few of my super smart friends went to university. That was way over my head, I'm like, ‘Fuck university.' But there was literally about 50 jobs in the world. You know, it's like there was only 50 jobs, and everyone or nearly everyone fitted into one of those 50. There was a few other ones but for the most part, nearly everyone fitted into about 50 jobs. I'm sitting there going— I won't say what but I'm earning pretty good money. I'm sitting in bare feet in my house talking to humans around the world about this stuff that I want to tell everyone about anyway.  I do it for free on my podcast and your podcast and I do it anyway. I have this great time, it's a really good experience. Then I finish at 7 pm. Then I walk 15 feet into the kitchen and put the kettle on and check my messages.  Lisa: No commuting, no travelling, no flying. Craig: I'm like, ‘How is this a job?' I'm like, ‘How is this real?' ‘This is a scam. I'm scamming everybody.' Like, how great is 2021? I know there's a lot of shit going on and I'm not trying to be insensitive, and it's smashed my business too. All of my live events for 2020 got kicked in the dick in two weeks, right? I got financially annihilated, but you just go, ‘Oh well, improvise, adapt, overcome and figure shit out.' But, I think when you can have it and a lot of people and it's a very well-worn kind of idea. But when you're, what you love, and what you're curious about, and how you make a few bucks, when that can all collide, then life is a different thing. Then there's not work and life, there's just life.  You know, and so when we talk about this idea of work-life balance, you know, it's like the old days that talk about that a lot. And it's like, almost like there was some seesaw, some metaphoric seesaw with work on one side and life on the other. And when you get balance like that— because what happens, think about this, if we're just basing it on numbers, like all 40 hours of work versus however many hours of non-work or however many hours of recreation and recovery. But if you're doing even 20 hours of a job that you hate, that's going to fuck you up. That's gonna, that's gonna mess with you physically, mentally, and emotionally. That's going to be toxic; that's going to be damaging; that's going to be soul-destroying, versus something else like me studying 40 hours a week, working 40, 50 hours a week doing 90 in total, depending on the week and loving it, and loving it. And going, ‘I feel better than I've ever felt in my life.'  I still train every day, and I still, I live 600-800 metres from the beach, I still walk to the beach every day, you know. And I still hang out with my friends. You know, it's like, it doesn't have to be this cookie-cutter approach. The beauty I think of life, with your food, with your lifestyle, with your career, with your relationships with the way that you learn, like the way that you do business, everything now is so much more flexible, and optional than any time ever before that we can literally create our own blueprint for living. Lisa: Yeah. And then it's not always easy. And sometimes it takes time to get momentum and stuff. Being, both you and I have both said before we're unemployable. Like, I'm definitely not someone you want to employ, because I'm just always going to run my own ship. I've always been like that, and that's the entrepreneurial personality. So not everyone is set up for that personality-wise. So you know, we're a certain type of people that likes to run in a certain type of way. And we need lots of other people when doing the other paths.  There is this ability now to start to change the way you think about things. And this is really important for people who are unhappy in where they're at right now. To think, ‘Hang on a minute. I've been I don't know, policeman, teacher, whatever you've been, I don't want to be there anymore. Is there another me out there? Is there a different future that I can hit?' The answer is yes, if you're prepared to put in the work, and the time, and the effort, the looking at understanding and learning, the change, being adaptable, the risk-taking, all of those aspects of it. Yes, but there is ways now that you can do that where they weren't 30 years ago, when I came out of school I couldn't be, I was going to be an accountant. Can you imagine anything worse than that?  Craig: Hi, hi. Shout out to all our account listeners, we love you and we need you. Lisa: I wasn't that— Academically that's I was good at it. But geez, I hated it. And I did it because of parental pushing direction. Thank goodness, I sort of wake up to that. And you know, after three years. I had Mark Commander Mark Devine on the show. He's a Navy SEAL, man. You have to have him on the show. I'll hook you up. He's just a buck. He became an accountant before he became a Navy SEAL and now he's got the best of both worlds really, you know, but like you couldn't get more non-accountant than Mark Devine. We all go into the things when we leave school that we think we're meant to be doing. And they're not necessarily— and I think you know, the most interesting 50 year-olds still don't know what the hell they want to be when they grow up. Just interrupting the program briefly to let you know that we have a new Patron program for the podcast. Now, if you enjoy Pushing the Limits, if you get great value out of it, we would love you to come and join our Patron membership program. We've been doing this now for five and a half years and we need your help to keep it on air. It's been a public service free for everybody, and we want to keep it that way. But to do that we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on www.patron.lisatamati.com. That's P-A-T-R-O-N dot lisatamati.com. We have two Patron levels to choose from. You can do it for as little as $7 a month, New Zealand, or $15 a month if you really want to support us. So we are grateful if you do. There are so many membership benefits you're going to get if you join us. Everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries and much, much more. So check out all the details: patron.lisatamati.com. And thanks very much for joining us. You know, I'm still in that camp. Craig: You raise a really interesting point too, and that is programming and conditioning. And, you know, because we all grow up being programmed, one way or consciously or not, we grow— if you grow up around people, you're being programmed. So that's not a bad thing. That's an unavoidable human thing. So, situation, circumstance, environment, school, family, friends, media, social media, all of that stuff shapes the way that we see the world and shapes the way that we see ourselves.  When you grow up in a paradigm that says, ‘Okay, Lisa, when you finish school, you have to go to university, or you have to get a job, or you have to join the family business, or you have to work on our farm,' or whatever it is, you grow up in that. You're taught and told and trained. And so you don't question that, you know. And for me, I grew up in the 70s, I finished in the 80s. I finished school in 1981. And I grew up in the country, and most people go to trade or most people worked in logging or on a farm or— and I would say about five in 100 of the kids that I did— by the way, doing year 12 was a pretty big deal in that time. ‘Geez, are you a brainiac?' Definitely wasn't a brainiac. But year 12 is a big thing now. Now, even if you have an undergrad degree that it's almost nothing really enough. It's like, you kind of got to go get honours, or masters or maybe even a PhD down the track. And that landscape has really changed. So it's just changing again to— you know, and I think to become aware— like this is for me, I love it; this is my shit; this is what I love— is starting to become aware of our lack of awareness. And starting to become aware of my own programming and go, ‘Oh, I actually think this. Why not? Because this is how I naturally think about, because this is how I've been trained to think about work. I've been trained to or programmed to think this way about money, or relationships, or marriage, or eating meat, or being a Catholic or being an atheist or voting liberal law,' or whatever it is, right.  Not that any of those things are good or bad, but it's not about how I eat or how I vote or how I worship. It's about how I think. And is this my thinking? Or is this just a reflection of their thinking, right? So when we open the door on metacognition now we start to become aware of our own stories, and where they come from. And this is where I think we really start to take control of our own life, and our own present, and our own future that doesn't exist, by the way, but it will, but it won't be the present.  Then, we start to write our own story with our own voice, not our parents' voice, not our friends', not our peers' voice, you know. And we're always going to be influenced by other people. Of course. Just like people are influenced by you and your podcast, and your stories, and your thinking, and your lessons for them. They're influenced. But I always say to people, ‘Don't believe me because you like me. Listen to me, if you like me and consider what I say. If what I say sounds reasonable for you, maybe a good idea to test drive, take that idea for a test drive, and see if that works for you, because it might not.' Right?  I think, I really encourage people to learn for themselves and to listen to their own internal wisdom that's always talking. So listen to smart people. I don't know if Lisa and I are in that category, Lisa is, listen to her. But at the same time, do your own, learning through exploration and trial and error, and personal kind of curiosity and drive.  For me, I opened my first gym at 26; first personal training centre in Australia, there weren't any. I'd never done a business course, I've never done an admin course, I knew nothing about marketing. I knew nothing about employees. I knew nothing. But I learned more in one year than I would say, most people would learn in five years at university studying business, because I was in the middle of it, and I was going to sink or swim. So in one year, I started a business and I acquired overwhelming knowledge and skill because I had to, because of the situation. But that was all learning through doing.  The way that you've learned, you know you said earlier that, like, a lot of people think that they're not academic; therefore, they're not smart. Some of the smartest people I've ever met, and I don't— and this not being patronising, but like, mind-blowingly brilliant, how they think, live outside of academia. One of the reasons some people are so brilliant outside of academia is because they're not forced into an echo chamber of thought. They're living outside the academic paradigm, where we're not trying to restrict how you think or write or speak. There are no rules out here. So there's no intellectual inhibition.  Lisa: Yeah, I love that. Craig: When you do a PhD, like me, and I can separate the two, thankfully. But there's a way of communicating and writing in PhD land, which is incredibly restrictive because of the scientific process, which is fine, I get that. But it's having an awareness of— this is what I'm often talking to my supervisors about is, yes, I'm studying this thing, which is deep, deep neuropsychology, and everything, the way that you do your research, get your data or interpret your data. The whole process of creating new science, which is what you're doing as a PhD, creating, bringing something new into the world. That's one thing. But you write your journal articles, which is my PhD process, you get them, hopefully, you get them published in academic resources and magazines. But then, I don't want that to be it. I'm going to write a book when I finish about all of my research totally in layman's terms so that people can use the knowledge, so that people can— because that's the value.  For me handing in some papers and going, ‘Oh, Craig Harper is an academically published author.' That's cool, but it's not— and I'm so respectful of people who have had hundreds of things published, but that doesn't blow my socks off. I'm not really— like that's a real, you really hang your hat on that in academia. Oh, how many things he or she had published, publications, which is cool. They're all smarter than me. But I'm not. I'm like, yeah, that that's cool. But I want to connect with the masses, not the few. Also, by the way, people who read academic papers, they raise it— they're reading it generally, just like I am right now, for a specific reason which relates to their own research. There ain't too many people like you. You're one of the rare ones who just thumb through fucking academic journals to make your life better. Lisa: Yeah. And it's just some real goals. So you've got the wisdom of having lived outside of academia and being a pracademic, as Paul Taylor says, and then actually seeing the pre— and this is a discussion that I had when I was talking to someone about doing a PhD and they say, ‘But then you're going to become a part of the establishment, and you're going to be forced into this box.' And I said, ‘No, not necessarily because it's— I can see where you're coming from. But you can take that, because you have that maturity and that life experience and you can fit yourself into the box that you have to fit into in order to get those things done. That research done, but you don't have to stay there.'  That's what you know, one of my things has been, I don't want to spend however many years doing a PhD, and then that's not out on the world. To me that that needs to be taken out of the academic journals, wherever you go to publish, and then put out into a book or something that where it's actually shared, like you say, with the masses, because otherwise, it just collects dust like your MA does, or your whatever, you know, that sits on your bookshelf, and how you got hey, your exam your piece of paper, but you didn't actually do anything with it.  Of course, lots of people do their thing, they're going like they're in research, and they're furthering research and so on. But I— my approach, I think yours is too, is to be able to communicate that information that you've learned, and then share it with everyone, so that they can actually benefit from it, and not just the people that are in academia. The other thing I see after interviewing hundreds of doctors and scientists and people is that they are, actually, the more specialised they are, the more inhibited they are by what they can and can't say.  While they need to be doing that because they need to protect what they are doing in their studies and what they're allowed to and what they're not allowed to do and say, it also is very inhibiting, and they don't get the chance to actually express what they would actually like to say. That's a bit of a shame, really, because you don't get to hear the real truth in the qualifying everything flat stick. Craig: I reckon you're exactly right. But they don't need to be that. And the reason that a lot of academics are like that is because they get their identity and sense of self-worth from being an academic. They're way more worried about three of their peers hearing something that might not be 100% accurate, and then being reprimanded or, rather than just going— look, I always say to my academic, super academic friends, when I talk with them, not everything that comes out of your mouth needs to be research-based. You can have an idea and an opinion. In fact, I want to hear your ideas and opinions. Lisa: You're very educated. Craig: You know, that's the— and as for the idea of you becoming an academic, No, you go, you do your thing you study, you learn the protocol, the operating system, and you do that you go through that process, but you're still you. Right, and there's— you and I both know, there are lots of academics who have overcome that self-created barrier like Andrew Huberman.  Lisa: Yeah, who we love. Craig: Who we love, who, for people listening, he's @hubermanlab on Insta, and there's quite a few academics now, like the one that I spoke on before, on Joe Rogan. She's a Harvard professor, she's a genius, and she's just having a— it's a three-hour conversation with Rogan, about really interesting stuff.  There's been a bit of a shift, and there is a bit of a shift because people are now, the smart academics, I think, are now starting to understand that used the right way, that podcasts and social media more broadly, are unbelievably awesome tools to share your thoughts and ideas and messages. By the way, we know you're a human. If you get something wrong, every now and then, or whatever, it doesn't matter. Lisa: Well, we'll all get, I mean, you watch on social media, Dr Rhonda Patrick, another one that I follow? Do you follow her? Fantastic lady, you know, and you watch some of their feeds on social media, and they get slammed every day by people who pretending to be bloody more academic than her. That just makes me laugh, really. I'm just like, wow, they have to put up with all of that. The bigger your name and the more credibility you have as a scientist, the more you have to lose in a way.  You know, even David Sinclair another you know, brilliant scientists who loves his work. And I love the fact that he shared us with, you know, all his, all his research in real-time, basically, you know, bringing it out in the book Lifespan, which you have to read, in getting that out there in the masses, rather than squirrelling it away for another 20 years before it becomes part of our culture, and part of our clinical usage. We ain't got time for that. We have to, we're getting old now. I want to know what I need to do to stop that now. Thanks to him, you know, I've got some directions to show them. Whether he's 100% there, and he's got all the answers? No. But he's sharing where we're at from the progress. Science by its very nature is never finished. We never have the final answer. Because if someone thinks they do, then they're wrong, because they're not, we are constantly iterating and changing, and that's the whole basis of science. Craig: Well just think about the food pyramid. That was science for a few decades. Lisa: Lots of people still believe that shit. That's the scary thing because now that's filtering still down into the popular culture, that that's what you should be doing, eating your workbooks and God knows what. This is the scary thing, that it takes so long to drip down to people who aren't on that cutting edge and staying up with the latest stuff, because they're basically regurgitating what there was 20 years ago and not what is now.  Now Craig, I know you've got to jump off in a second. But I wanted to just ask one more question, if I may, we're completely different. But I want to go there today because I'm going through this bloody shingles thing. Your mate Johny that you train, and who you've spoken about on the last podcast, who had a horrific accident and amazingly survived, and you've helped him, and he's helped you and you've helped him learn life lessons and recover, but he's in constant chronic pain.  I'm in constant chronic pain now, that's two and a half weeks. For frick's sake, man, I've got a new appreciation of the damage that that does to society. I just said to my husband today, I've been on certain drugs, you know, antivirals, and in pain medication. I can feel my neurotransmitters are out of whack. I can feel that I'm becoming depressed. I have a lot of tools in my toolbox to deal with this stuff, and I am freely sharing this because what I want you to understand is when you, when you're dealing with somebody who is going through chronic pain, who has been on medications and antibiotics, and God knows whatever else, understanding the stuff that they're going through, because I now have a bit of a new appreciation for what this much of an appreciation for someone like Johnny's been through. What's your take on how pain and all this affects the neurotransmitters in the drugs? Craig: Do you know what? Lisa: You got two minutes, mate. Craig: I'm actually gonna give you I'm gonna hook you up with a friend of mine. His name is Dr Cal Friedman. He is super smart, and he specialises in pain management, but he has a very different approach, right? He's a medical doctor, but look, in answer to, I talked to Johnny about the pain a bit, and we have, we use a scale, obviously 10 is 10. 0 is 0. There's never a 0. Every now and then it's a 1 or 2, but he's never pain-free. Because he has massive nerve damage. And sometimes, sometimes he just sits down in the gym, and he'll just, I'll get him to do a set of something, and he'll sit down and I just see this, his whole face just grimaces. He goes, ‘Just give me a sec.' His fist is balled up. He goes, sweat, sweat. I go, ‘What's going on, mate?' He goes, ‘It feels like my leg, my whole leg is on fire.'  Lisa: Yeah. I can so relate to that right now.  Craig: Literally aren't, like, burning, like excruciating. I don't think there's any, I mean, obviously, if there was we'd all be doing it. There is no quick fix. There is no simple answer. But what he has done quite successfully is changed his relationship with pain. There is definitely, 100% definitely, a cognitive element to, of course, the brain is, because the brain is part of the central nervous system. Of course, the brain is involved. But there's another element to it beyond that, right.  I'm going to tell you a quick story that might fuck up a little bit of Dr Cal, if you get him on. He has done a couple of presentations for me at my camps. He's been on my show a little bit. But he told this story about this guy at a construction site that was working and he had a workplace accident. And he, a builder shot a three-inch nails through his boots, through his foot. Right? So the nail went through his foot, through the top of the leather, and out the sole, and he was in agony, right? He fell down, whatever and he's just rolling around in agony and his mates, they didn't want to take anything off because it was through the boot, through his foot.  They waited for the ambos to get there, and they gave him the green whistle. So you know that whatever that is, the morphine didn't do anything, he was still in agony. He was in agony. Anyway, they get him into the back of the ambulance and they cut the boot off. And the nail has gone between his big toe and second toe and didn't even touch his foot.  Lisa: Oh, wow. In other words, psychologically—  Craig: There was no injury. But the guy was literally in excruciating pain, he was wailing. And they gave him treatment, it didn't help. He was still in pain. So what that tells us— Lisa: There is an element of—  Craig: What that tells us is our body can, our mind can create real, not perceived, but real pain in your body. And again, and this is where I think we're going in the future where we start to understand, if you can create extreme pain in your body where there is no biological reason, there is no actual injury, there's no physical injury, but you believe there's an injury, now you're in agony.  I think about, and there's a really good book called Mind Over Medicine by a lady called Lissa Rankin, which we might have spoken about. L-I-S-S-A, Lissa Rankin, Mind Over Medicine. What I love about her is, she's a medical doctor, and she gives case after case after case of healing happening with the mind, where people think placebos and no-cebos, people getting sick, where they think they're getting something that will make them sick, but it's nothing, they actually make themselves sick. And conversely, people getting well, when they're not actually being given a drug. They're being given nothing, but they think it's something. Even this, and this is fascinating, this operation, pseudo-operation I did with people where—  Lisa: Yeah, I read that one. I read that study. Craig: Amazing. Craig: Oh, yeah, it's look, pain is something that even the people who are experts in it, they don't fully understand. Lisa: Well, I just like, if I can interrupt you there real briefly, because I've been studying what the hell nerve pain, and I'm like, my head, my sores are starting to heal up right. So in my head, I'm like ‘Whoa, I should be having this pain, I'm getting more pain from the burning sensation in my legs and my nerves because it's nerve pain.' So I read somewhere that cryotherapy was good. So in the middle of the night, when I'm in really bad pain, instead of lying there and just losing my shit, and have I now have been getting up every night and having two or three cold ice-cold showers a night, which probably not great for my cortisol bloody profile, but it's, I'm just targeting that leg. That interrupts the pain sensation for a few minutes.  What I'm trying to do as I go, I'm trying to go like, can I—am I getting pain because my brain is now used to having pain? Is it sending those messages, even though there's no need, the sores are healing?  Craig: That is possible. Lisa: Am I breaking? And I can break the pain for about 10 minutes, and then it will come back in again. But I'm continuing on with it, that idea that I can interrupt that pain flow. Then of course, during the breathe in, the meditation, the stuff and sometimes you just lose your shit and you lose it, and then you just start crying, ‘Mummy, bring me some chicken soup' type moments. But it's really interesting. I mean, I just like to look at all these shit that we go from and then say, ‘Well, how can I dissect this and make this a learning curve?' Because obviously, there's something wrong, but I just, I feel for people that are going through years of this. Craig: It's, yeah, I'm the same I feel. Sometimes I work with people, where I work with and as do you, I work with a lot of people who have real problems. I don't have any problems. I mean, they have real problems. And I'm, despite my appearance, I'm quite, I'm very compassionate. It's hard for me because I, it upsets me to see people in pain. I feel simultaneously sad and guilty. How do I deserve this? But it just is what it is. But people like John and a lot of the people that I've worked with and you've worked with, you know, people like that inspire me.  I mean, they're— I don't find typical heroes inspirational. They don't really inspire me like the people we normally hold up as, I mean, well done. I think they're great, but they don't inspire me. People who inspire me or people who really, how the fuck are you even here? How do you turn up? He turns up. He's actually in hospital right now because he's got a problem that's being fixed. But, and he's in and out of hospital all of the time. And then he turns up, he hugs me and he goes, ‘How are you?' I go, ‘I'm good.' He goes, ‘Now look at me.' So I look at him. And he goes, ‘How are you really?' And I go, ‘I'm good.' This is the guy who—  Lisa: Who's dealing with so much. I've got a friend, Ian Walker8, who I've had on the show, too, so he got hit by a truck when he was out cycling, I think it was years and years ago. He ended up a paraplegic. And then he recovered, he didn't recover, he's still in a wheelchair, but he was out racing his wheelchair, he did wheelchair racing, and he's part of our club and stuff. And then he got hit by another truck, now he's a quadriplegic.  This guy, just, he is relentless in his attitude, like he is, and I've seen him dragging himself like with his hands because he's got access now to his hands again. After working for the last couple of years, and he kind of, on a walker frame thing, dragging himself two steps and taking a little video of him, dragging his feet, not the feet out, working, they're just being dragged. But the relentless attitude of the guy, I'm just like, ‘You're a fricking hero. You're amazing. Why aren't you on everybody magazine cover? Why aren't you like, super famous?' Those people that really flip my boat. Craig: Yeah. And I

David Sinclair is a Harvard researcher who believes aging is a treatable disease. His book Lifespan: Why We Age and Why We Don't Have To is available now.

A panel talk with scientists and thought leaders in age reversal and longevity science. Featuring: Aubrey de Grey (Founder of SENS Research Foundation, author of "Ending Aging")  David Sinclair (Harvard Medical School, Life Biosciences, author of "Lifespan: Why We Age -- and Why We Don't Have to") Joao Pedro de Magalhaes (University of Liverpool, CSO at Centaura) Liz Parrish (Founder of Bioviva Science) Jean Hebert (Albert Einstein College of Medicine, author of "Replacing Aging") Alexandra Stolzing (SENS Research Foundation, Loughborough University) Greg Fahy (Intervene Immune) David Gobel (Methuselah Foundation, Methuselah Fund) Hosted by: Laura Minquini (MYKIGAI, Let's Talk Longevity), Avi Roy (Oxford University), and Nathan Cheng (Longevity Marketcap / Longevity List)  

Oxygen therapy to lengthen our telomeres and prolong the life of our chromosomes. Boosting the functioning of our mitochondria with NAD. Stem cell rejuvenation. These are just some of the exciting therapies that scientists are exploring in their quest to prevent the decline and suffering we experience as we age. But some scientists argue that these are just partial fixes and that the answer to the eternal quest for the fountain of youth lies in pinpointing the upstream driver of these hallmarks of ageing. They claim that thanks to breakthroughs in the science of genetics they have finally discovered the control system that generates the strength and health we associate with youth. It's the “epigenome”, which is the packaging that coils around our DNA and switches on and off the genes that shape the identity of our cells. They say that as we age this packaging unravels, which deregulates the DNA and cell information they have been safeguarding. Fix the packaging and we can completely reset our DNA and cells and regenerate our bodies so they are once again like brand new. Skeptics say that we need to look no farther than evolution to recognize that while ageing can be slowed down it can't be abolished. Despite the formidable powers of natural selection, a species that doesn't age and die has not emerged. This is because ageing is marked not just by cells that are slowing down but also by cells that are rapidly multiplying and becoming cancerous. It is impossible to fix one without the other benefiting, a form of intercell competition where human beings and our hopes of eradicating old age are the losers. Arguing for the motion is David Sinclair, Professor of Genetics at Harvard Medical School and one of TIME Magazine's “Top 50 people in health care”. He is the author of over 200 scientific papers as well as the New York Times bestseller Lifespan: Why We Age—and Why We Don't Have To. Arguing against the motion is Joanna Masel, Professor of Ecology & Evolutionary Biology at the University of Arizona. She is a mathematical modeller who has published over 50 papers in a variety of scientific fields and is the author of Bypass Wall Street: A Biologist's Guide to the Rat Race. Sources: ZNews, Fox News, WKTV Newschannel2, Science Time The host of the Munk Debates is Rudyard Griffiths - @rudyardg.   Tweet your comments about this episode to @munkdebate or comment on our Facebook page https://www.facebook.com/munkdebates/ To sign up for a weekly email reminder for this podcast, send an email to podcast@munkdebates.com.   To support civil and substantive debate on the big questions of the day, consider becoming a Munk Member at https://munkdebates.com/membership Members receive access to our 10+ year library of great debates in HD video, a free Munk Debates book, newsletter and ticketing privileges at our live events. This podcast is a project of the Munk Debates, a Canadian charitable organization dedicated to fostering civil and substantive public dialogue - https://munkdebates.com/ The Munk Debates podcast is produced by Antica, Canada's largest private audio production company - https://www.anticaproductions.com/   Executive Producer: Stuart Coxe, CEO Antica Productions Senior Producer: Christina Campbell Editor: Kieran Lynch Producer: Nicole Edwards Associate Producer: Abhi Raheja

I'm covering David Sinclair's new book, "Lifespan: Why We Age—and Why We Don't Have To." Contained here are some interesting theories and discussions about aging and age-related diseases.  I also touched on the topics of Valter Longo's Prolon FMD (fasting-mimicking diet), vitamin K2 carboxylation and vitamin K2-dependent enzymes, inflammation tests (Hs-CRP, MPO, Lp-PLA2, and MACR), the secret life of fat cells, and niacin. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

How does the body age? There are many theories about the aging process. In his new book "Lifespan: Why We Age—and Why We Don't Have To," longevity researcher Dr. David Sinclair discussed interesting concepts, like the information theory of aging and the so-called "zombie cells."  For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

With special guest: David Sinclair PhD AO… in conversation with Bill Kable Lifespan: Why We Age – and Why We Don’t Have To is a visionary book in a fast moving field. In fact when we talk to Dr David Sinclair for today’s program we discover that there have been some amazing developments in the scientific research of aging even since the book was written. The immediate response of some people to aging research is that death at a certain age is the natural order of things. Perhaps you might hear that someone has had a look at old age and now does not want to lengthen this time in that person’s life. But would we want to go back to the time not so long ago when life expectancy was more like 40 than the current 80? What if by controlling aging we could reduce rather than extend time spent in total dependency in a nursing home? Podcast (mp3)

This is part 3 of our series on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." We'll talk about 3 concepts—rapamycin, mTOR, autophagy. Rapamycin (an antibiotic) inhibits mTOR (a protein). mTOR inhibits autophagy. Autophagy is a natural process by which the body eliminates unnecessary components (like dead mitochondria). So, does rapamycin have an effect on aging and longevity? That's what we'll discuss in the podcast.  For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

In this episode, I have the pleasure to interview Dr. David Sinclair. David is a professor in the Department of Genetics at Harvard Medical School. Time magazine has named him one of the 100 most influential people in the world and among the top 50 people in healthcare. He and his colleagues study sirtuins - protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction - as well as other subjects like learning, memory, neurodegeneration, cancer and cellular reprogramming. Our conversation today is all about his book Lifespan: Why We Age - and Why We Don't Have To. David believes that aging is a disease and that we may soon have the tools to put it into remission. This has been one of my favorite conversations to date. Please enjoy this amazing conversation with Dr. David Sinclair. Today's episode is sponsored by Audible. Try Audible for free: www.bookthinkers.com/audibletrial. The purpose of this podcast is to connect you, the listener, with new books, new mentors, and new resources that will help you achieve more and live better. Each and every episode will feature one of the world's top authors so that you know each and every time you tune-in, there is something valuable to learn. If you have any recommendations for guests, please DM them to us on Instagram. (www.instagram.com/bookthinkers) If you enjoyed this show, please consider leaving a review. It takes less than 60-seconds of your time, and really makes a difference when I am trying to land new guests. For more BookThinkers content, check out our Instagram or our website. Thank you for your time!

本期节目的嘉宾是我们的朋友黄宇翔。黄宇翔是美国密歇根大学安娜堡分校分子、细胞与发育生物学的博士学生，主要研究方向是细胞代谢。他也是科学新媒体"知识分子"的撰稿人，目前正在创作《科研外史》，一部以科学史为主题，以武侠为风格的非虚构文集。“有人的地方就有江湖。”作为一门实验科学，生物科研的江湖是什么样的？为什么在黄宇翔看来，生物化学法和遗传学法分别对应降龙十八掌、掷暗器这样的绝顶武功？如果科研史是一部武侠小说，它的精神内核是什么？如果说做研究也是修行，研究者以什么为目标、如何理解自己的角色？在广为人知的科学结论背后往往是无数次失败的经历，而这些探索的过程恰恰构成了科学的基石。为什么这些经历值得被记录、为什么科普写作是重要的？在传递事实信息之外，科普写作又如何传递知识？从高中生物与生物学研究的区别讲起，黄宇翔和我们在这期节目中聊到了科研观、研究者身份、科研武侠、科普写作等话题。本期嘉宾黄宇翔内容提要+精彩预告01:15 生物科学的研究和高中生物课程有什么区别？“说生命科学是文科是完全错误的概念。生物学是一门实验科学，高中生物学课本上的每一个概念背后都有实验支持。高中生物学课本上过度强调了结论性的东西，使得很多人对生物失去了兴趣。”“本科生物学训练强调知识是怎么来的这一过程。”“十九世纪以前的生物学研究叫natural history，自然史或者博物学，是非常描述性的研究。这和当代强调逻辑和抽象概念的生物学研究有所不同。”“生物学上没有百分之百确定的东西，都是在限定条件下的结论。”06:40 生物医学的原创性和重要性“真正开创领域的工作在刚刚发现的时候大部分人无法认识到其重要性。”“作为细胞自噬这个现象最最早发现的人之一，我的导师在90年代观察到这个现象的时候还觉得很郁闷，因为人们不觉得它重要。直到90年代末，人们发现细胞自噬与癌症发病原因的关系，才意识到这个生理学过程的重要意义。”10:58 什么事值得研究的？-不同科学家的科研观“分子生物学的先驱Max Delbrück说过Don't follow the fashion science. 一个科研问题如果大部分人都知道它重要了，那就不要去研究他了。因为有没有你，也会有人能做出来。”“生物学研究的很多竞争很像武侠小说中的华山论剑。大家都想争取第一，但是通过不同的途径。”“生物化学途径像降龙十八掌，是非常霸道的外家功夫，从上百升的培养液中提取中不同的组份进行实验。思路比较简单，但是比较消耗内力。”“遗传学像剑或是暗器，通过化学物质诱发随机突变探索克隆基因的方法。”“两种方法思路非常不一样，但是殊途同归，几乎是同一时间把同一基因克隆出来并一起获得了2001年的诺贝尔生理学奖。”20:20 对武侠的兴趣：做研究也是修行“生物学研究大部分时候是很重复且枯燥的。研究是Re-search，需要你一次又一次的去探索。”“关于武侠的联想是我在科研中找乐子的方法。”“科研大部分时候还是很艰苦的。探究知识的边界大多会以失败收尾，给自己找一些正反馈就很重要。”29:20 生物医学武侠的精神内核：“为苍生的健康谋福利”“从大的学科角度说生物医学研究以科学为手中的宝剑，以愚昧无知作为敌人，为苍生的健康谋福利。从个人的角度说，武侠小说是成年人的童话。我未必能成为封号斗罗或绝世大侠，我也没有天资聪颖，可能放在武侠小说里就是路人甲。我能做到的就是努力把自己的武功练扎实，能做到无愧于心，不要浪费有限的武功，不要让时光虚度掉。做些有益的事情，在过程中充实自己享受过程。”32:00 从《斯通纳》一个本关于学者的一生的小说中获得的启发“不是每个人都要成为那个站在山顶上的人。做自己的英雄，去做一些有益于社会事情。焚膏油以继晷，恒兀兀以穷年。也是一种很好的人生选择。”34:00 对科普写作的兴趣“最开始写科学史科普的时候是出于对学术文章背后科研探索过程的好奇。”“文章是很清晰的，但是探索的过程是曲折的。”“在接近崩溃的时候，如何通过身边人的鼓励而坚持下来。”“一个项目可能六七年前就开始做了，研究幕后的故事细节可能研究者本人都不太记得。但艰苦的奋斗过程如果不记录下来就太可惜了，这都是人类奋斗的经历”39:32 科普写作与播客节目“科普写作和播客都是希望记录冷冰冰的研究背后生动的人和事”“写科普也是希望把理性的科学逻辑传递给大家。”“研究的意义可能在回顾的时候才能够更加清楚，借助导师的见解也很重要。”“科学的前沿是通过武艺的切磋，互相的批评而推进的。“45:40 生物科学科学所理解的科学是什么样的？“生物科学的底层逻辑是必要性、充分性。”46:40 科普不是什么？“科普不是fact，是knowledge：科学中的结论是怎么来的，如何把fact整合成knowledge的过程是科普真正想传递的。这些科学思维可以帮助我们更理性地思考一些现象。”“有人给你展现了一段推理的过程，你可以思考它是不是有道理。这是科普想要传达的思维。”“我们要明白这个结论在什么条件下才成立。一个结论常常只是在一个很小的范围内才成立的。写科普的一大动力是希望大家能以更批判的角度看待问题。”50:40 做科普的感受“做科普写作对自己最直接的影响是增长了自己的科研修养，武器库，扩充了自己的科研思路。”“通过采访老科学家一路的科研生涯也拓宽了我对于科学作为一种职业的的理解。”52:40 总结“科学是一个过程，它的背后是很多有血有肉、像我们一样普通的平凡人。”54:00 书籍推荐Li, J. J. (2006). Laughing gas, Viagra, and Lipitor: The human stories behind the drugs we use. Oxford University Press. “药物发现背后的故事”Sinclair, D. A., & LaPlante, M. D. (2019). Lifespan: Why We Age—and Why We Don't Have To. Atria Books. “明星科学家实验室背后的故事；关于衰老医学的见解。”Ribatti, D. (2018). Judah Folkman: A Biography. Springer. “一位医生科学家的传记。”参考资料黄宇翔在知识分子发表的文章列表：http://zhishifenzi.com/u/2425.html李少峰. (2017年09月28日). "知乎大v王立铭:相信伪科学只需要本能". 长江日报. Retrieved from: http://www.cjrbapp.cjn.cn/p/1694.html片头片尾音乐《Sunrise at Seaside》by 王乾-----------双重意识是一档「让我们认识到那些我们以为此时此刻与我们生活需求没有关联的东西其实和我们紧密相关」的播客节目。你可以在苹果播客, 喜马拉雅，网易云音乐，荔枝fm，小宇宙APP和Spotify搜索"双重意识DoubleConsciousness"找到我们，关注我们并收听我们的节目。欢迎大家在微信后台或是微博(@双重意识DoubleConsciousness)等各大平台给我们留言、提供反馈意见。

Metformin is a popular anti-diabetes medication. But it is also said to be an anti-aging drug. This podcast is based on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." Here, we'll talk about metformin, metformin's benefits, multiple metabolic pathways impacted by metformin, and the TAME study (Targeting Aging with Metformin).For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's metformin articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

Metformin is a popular anti-diabetes medication. But it is also hailed as an anti-aging drug too. This podcast is based on David Sinclair's new book, "Lifespan: Why We Age and Why We Don't Have To." We'll talk about metformin, metformin's benefits, multiple metabolic pathways impacted by metformin, and the TAME study (Targeting Aging with Metformin).For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's blog articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

How do we know when something is wrong with us? I want to understand the testing process we have for COVID19. I want to understand "symptomatic" cases vs. "asymptomatic" cases. And who's data should we trust? So I called David Sinclair. He runs The Sinclair Lab at Harvard Medical School and is the New York Bestselling author of "Lifespan: Why We Age?and Why We Don't Have To." I also want to know how do I build up my immune systems? What steps can I take RIGHT NOW? And how do I keep this going over time? And what's going on with testing for COVID19? What are the numbers? And why are they off? David breaks this down. And he explains which coronavirus tests are bringing us into the future of science and biology. He'll also help you understand who's at risk (everyone). And how to protect yourself. AND how to protect others. Because we're in this together. Also, I've been getting great feedback on how these episodes around the coronavirus are helping people make sense in a really confusing time. So thanks for your support. Right now, the best way to support this show is to support your own nutrition by checking out this special offer from our sponsor, Athletic Greens. Learn more. This is for your health. Go to athleticgreens.com/james Thanks. And stay well.- James I write about all my podcasts! Check out the full post and learn what I learned at jamesaltucher.com/podcast. Thanks so much for listening! If you like this episode, please subscribe to "The James Altucher Show" and rate and review wherever you get your podcasts: Apple Podcasts Stitcher iHeart Radio Spotify Follow me on Social Media: YouTube Twitter Facebook Linkedin Instagram ------------What do YOU think of the show? Head to JamesAltucherShow.com/listeners and fill out a short survey that will help us better tailor the podcast to our audience!Are you interested in getting direct answers from James about your question on a podcast? Go to JamesAltucherShow.com/AskAltucher and send in your questions to be answered on the air!------------Visit Notepd.com to read our idea lists & sign up to create your own!My new book, Skip the Line, is out! Make sure you get a copy wherever books are sold!Join the You Should Run for President 2.0 Facebook Group, where we discuss why you should run for President.I write about all my podcasts! Check out the full post and learn what I learned at jamesaltuchershow.com------------Thank you so much for listening! If you like this episode, please rate, review, and subscribe to "The James Altucher Show" wherever you get your podcasts: Apple PodcastsiHeart RadioSpotifyFollow me on social media:YouTubeTwitterFacebookLinkedIn

David A. Sinclair, Ph.D., is one of the world's most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him "one of the 100 most influential people in the world" (2014) and among the "Top 50 People in Healthcare" (2018). New York Times Bestselling author of Lifespan: Why We Age―and Why We Don't Have To.David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you'd most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world's top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab's discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing--and what that means for humanity going forward.He's applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results-- which, it should be noted, are completely anecdotal--are encouraging. He's now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award.- https://lifespanbook.com/Catch my book - Screw Being Shy, March 14th on my website markmetry.comPlease do NOT hesitate to reach out to me for any reason on LinkedIn, Instagram, via email mark@vudream.com, text me 508-925-0261!LinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast

A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time's most influential people. It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair's own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Dr. David Sinclair is author of "Lifespan: Why We Age and Why We Don't Have To" Dr. Sinclair was named one of Time Magazine's "Most Influential" people. This Harvard researcher reveals a bold new theory on why we age and talks to Cristina about his cutting edge research on how to extend our lifespans. He also reveals something about himself not heard in any other interview.

In this episode, Sal, Adam and Justin speak to Ben Greenfield about unschooling his kids, nootropics, putting on several pounds of muscle in just a few months, The Game Changers documentary, aging and more. Discussing a woman's proper place in the home. (2:10) Ben's ultimate pesto recipe from plants in your backyard. (4:52) Unschooling his sons: Free thinking, creating creative workers, identifying what you're passionate about & MORE. (7:28)   The importance of being an example to your kids and creating an environment that allows them to cultivate creativity. (15:07)  What challenges has he faced so far? (18:03) Fostering resilience and his son's rite of passage. (20:03) How has he incorporated plant medicine into his life? (23:12) Open relationships: Their connection to plant medicines, his take & MORE. (26:07) Why he believes everything was put on the planet for a purpose. (35:17) How Ben got JACKED! (39:50) The guys talk the Game Changers documentary, veganism vs carnivore, figuring out the right diet for you & MORE. (46:24) The overlooked psychological elements of food. (57:00) The proper balance of living a long & high quality of life and acknowledging one's mortality. (1:04:26) What excites him most in the field of anti-aging? (1:08:00) His six variables for mitochondria he addresses with everyone he works with. (1:14:37) Has he ever had something go wrong with any of his bio hacks? (1:17:36) Are his days as an endurance athlete numbered? (1:19:15) Featured Guest/People Mentioned Ben Greenfield Fitness (@bengreenfieldfitness)  Instagram Website Steven Kotler (@kotler.steven)  Instagram Paul Saladino, MD (@carnivoremd)  Instagram Dr. Joseph Mercola (@mercola)  Instagram/Twitter David Sinclair (@davidsinclairphd)  Instagram Related Links/Products Mentioned October Promotion: MAPS Anabolic ½ off!! **Code “RED50” at checkout** Visit Kion for an exclusive offer for Mind Pump listeners! **Code “mindpump10” at checkout for the discount.** Go Greenfields | a podcast for your palate 21 Lessons for the 21st Century - Book by Yuval Noah Harari Stealing Fire: How Silicon Valley, the Navy SEALs, and Maverick Scientists Are Revolutionizing the Way We Live and Work - Book by Jamie Wheal and Steven Kotler Mind Pump 760: Paleo f(x) Wrap-Up with the Mind Pump Crew The Truth About The Carnivore Diet: Everything You Need To Know About Dangers, Benefits, Mistakes & Hacks For Eating Only Meat. The Game Changers Official Film Website | Documentary What Can We Learn from the Kitavans? Lifespan: Why We Age—and Why We Don't Have To - Book by David Sinclair Earthing: The Most Important Health Discovery Ever – Book by Clinton Ober

David A. Sinclair, Ph.D., co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, has been listed in TIME magazine's “100 most influential people in the world” (2014), and appeared on their list of the "Top 50 in Healthcare" (2018). Dr. Sinclair is best known for his work into anti-aging and longevity, putting forth the idea that aging is a disease and we can uncover the tools to put it into remission. His book "Lifespan: Why We Age - and Why We Don't Have To" is a New York Times Bestseller. Full show notes: Dr. Sinclair|Mind-Jam Podcast

Today's guest is David Sinclair, professor of genetics at Harvard Medical School and co-director of the Paul Glenn Center Biological Mechanisms of Aging. He is widely considered on the world's foremost experts on longevity research. A co-founder of the journal Aging and several biotech companies, he also hold 35 patents. Dr. Sinclair is a recipient of more than 25 awards and honors, including being knighted in the Order of Australia. His work is featured in five books, two documentary movies, “60 Minutes,” Morgan Freeman's “Through the Wormhole,” and other media. His newest book, LifeSpan. Why We Age and Why We Don't Have To, was released in September 2019 by Simon and Schuster. Colin Miller and Dr. Keith Mankin host the popular medical podcast, PeerSpectrum. Colin works in the medical device space and Keith is a retired pediatric orthopedic surgeon. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's guest is David Sinclair, professor of genetics at Harvard Medical School and co-director of the Paul Glenn Center Biological Mechanisms of Aging. He is widely considered on the world's foremost experts on longevity research. A co-founder of the journal Aging and several biotech companies, he also hold 35 patents. Dr. Sinclair is a recipient of more than 25 awards and honors, including being knighted in the Order of Australia. His work is featured in five books, two documentary movies, “60 Minutes,” Morgan Freeman's “Through the Wormhole,” and other media. His newest book, LifeSpan. Why We Age and Why We Don't Have To, was released in September 2019 by Simon and Schuster. Colin Miller and Dr. Keith Mankin host the popular medical podcast, PeerSpectrum. Colin works in the medical device space and Keith is a retired pediatric orthopedic surgeon. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine

When it comes to anti-aging research, Dr. David A. Sinclair of Harvard Medical School is on the forefront of research and innovation. He joins on episode 231 to discuss his new book Lifespan: Why We Age – and Why We Don’t Have To. Dr. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and … Continue reading "231: David A. Sinclair | Anti-Aging Research And Understanding In “Lifespan”" The post 231: David A. Sinclair | Anti-Aging Research And Understanding In “Lifespan” appeared first on The Armen Show.

Anti-aging technology is here. And David Sinclair is the biologist, researcher and genetics professor with the answers to all my questions about how to live longer, how to reverse your biological clock, age better, or even anti-age. He just wrote the book, "Lifespan: Why We Age?and Why We Don't Have To." And runs The Sinclair Lab at Harvard Medical School... But before you press play, I'll tell you the best part. We don't have to wait or be babies to take advantage of this technology. All we have to do is be alive.   And I have an announcement for my listeners. I'm giving away free copies of my new book, "The Side Hustle Bible. This book is a collection of 177 proven ways to extra income. Make sure to click play to hear how you can claim a copy today. I write about all my podcasts! Check out the full post and learn what I learned at jamesaltucher.com/podcast. Thanks so much for listening! If you like this episode, please subscribe to "The James Altucher Show" and rate and review wherever you get your podcasts: Apple Podcasts Stitcher iHeart Radio Spotify   Follow me on Social Media: YouTube Twitter Facebook Linkedin Instagram ------------What do YOU think of the show? Head to JamesAltucherShow.com/listeners and fill out a short survey that will help us better tailor the podcast to our audience!Are you interested in getting direct answers from James about your question on a podcast? Go to JamesAltucherShow.com/AskAltucher and send in your questions to be answered on the air!------------Visit Notepd.com to read our idea lists & sign up to create your own!My new book, Skip the Line, is out! Make sure you get a copy wherever books are sold!Join the You Should Run for President 2.0 Facebook Group, where we discuss why you should run for President.I write about all my podcasts! Check out the full post and learn what I learned at jamesaltuchershow.com------------Thank you so much for listening! If you like this episode, please rate, review, and subscribe to "The James Altucher Show" wherever you get your podcasts: Apple PodcastsiHeart RadioSpotifyFollow me on social media:YouTubeTwitterFacebookLinkedIn