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What if you could test your cognition from the comfort of your own home using a smartphone? Drs. David Berron and Lindsay Clark have spent years researching cognitive neuroscience, culminating in a 2024 published study investigating the effectiveness of a smartphone app as a tool for detecting cognitive impairment outside of a clinic or research setting. Drs. Berron and Clark join Dementia Matters to discuss how the app and tests were developed, the benefits and drawbacks of this approach  and the implications of remote testing in the healthcare field. Guests: David Berron, PhD, Clinical Cognitive Neuroscience research group leader, German Center for Neurodegenerative Diseases (DZNE), and Lindsay Clark, PhD, licensed neuropsychologist, clinical core co-lead, Wisconsin Alzheimer's Disease Research Center (ADRC), assistant professor, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health Show Notes Read Drs. Berron and Clark's study, “A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices,” online through the journal npj Digital Medicine. Learn more about Dr. Berron and his research on his website. Learn more about Dr. Clark on her profile on the Wisconsin ADRC's website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production.

How to look younger than your age for longer? We all want to age gracefully and keep our youthful looks for as long as possible. Thankfully, there are a couple of simple rules you can follow to make that happen! One of the main things that can significantly shorten your telomeres is stress. Luckily, there's a solution for all your worries: meditation! Multiple studies have confirmed its efficiency in dealing with telomeres becoming shorter. The best option here is Zen meditation. Scientists from the University of Zaragoza in Spain discovered that, on average, Zen meditators have longer telomeres than any other people of their age! #livelonger #vitamins #lookyoung TIMESTAMPS Manage your stress level 0:30 Surround yourself with people you like 1:28 Eat less 2:05 Rack your brain 3:05 Wear sunscreen 3:33 Dance 4:22 Go to sleep earlier 4:47 Add more vitamins to your diet 5:41 Drink more tea 6:26 Music by Epidemic Sound https://www.epidemicsound.com/ SUMMARY: - As it turns out, one of the main things that can significantly shorten your telomeres is stress. Luckily, there's a solution for all your worries: meditation! - The other secret to staying young is having people you love and appreciate around you. - Burgers and cupcakes are delicious, but a study published in Nature Communications journal confirmed that caloric restriction is way more beneficial for keeping a fresh and youthful look. - Scientists from Rutgers University discovered that learning boosts the number of neurons you have, which helps your brain stay younger. - It doesn't matter if it's sunny or cloudy — unfortunately, UV rays are always there waiting to damage your skin. They not only break down elastin but also cause other skin problems like wrinkles and an uneven skin tone. - A study from the German Center for Neurodegenerative Diseases came to a fascinating discovery: dancing is one of the most effective types of exercise to reverse the aging process! - Having a steady sleeping regime is extremely important for your inner and outer health. - Believe it or not, antioxidants are extremely important for our looks as they prevent free radicals from damaging the cells in our bodies. - Bad news for all the coffee lovers out there! A recent Israeli study found that tea drinkers live longer! Do you know any other tricks to slow down the aging process? Tell us in the comments below. Subscribe to Bright Side : https://goo.gl/rQTJZz ---------------------------------------------------------------------------------------- Our Social Media: Facebook:   / brightside   Instagram:   / brightgram   5-Minute Crafts Youtube: https://www.goo.gl/8JVmuC ---------------------------------------------------------------------------------------- For more videos and articles visit: http://www.brightside.me/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Helena Gellersen, narrates her blog written for the Dementia Researcher website. Helena shares valuable tips on making the most of academic conferences, particularly the Alzheimer's Association International Conference (AAIC). She offers practical advice on leveraging conference resources, setting goals, effective networking, and presenting research. She emphasises the importance of preparation, strategic planning, and follow-up to enhance the conference experience and foster meaningful connections, ultimately advancing one's career. Her guidance is particularly beneficial for early career researchers navigating the often overwhelming environment of large academic conferences. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-ultimate-guide-to-making-the-most-of-the-aaic/ -- Dr Helena Gellersen is a Postdoctoral Researcher at the German Center for Neurodegenerative Diseases (DZNE) and current Education Chair Trainee for the ISTAART Neuroimaging. The focus of Helena's work is on identifying preclinical signatures of Alzheimer's disease and to develop novel memory and neuroimaging markers for the early detection of Alzheimer's disease and for monitoring disease progression. @HGellersen Find out more about the Neuroimaging PIA and ISTAART at alz.org/istaart -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

n the upcoming episode of The Science of Aging Podcast, we dive deep into the critical questions surrounding mouse models in aging research with our special guest, Dr. Dan Ehninger from the German Center for Neurodegenerative Diseases (DZNE) in Bonn. Dr. Ehninger, a visionary in the field of biogerontology, brings to the table his controversial and thought-provoking perspectives on the limitations and potential pitfalls of relying on mouse models for understanding human aging. We'll dissect the intricacies of rapamycin and caloric restriction studies, the debate over the mouse model's relevance to human aging, and innovative approaches to designing more effective mouse studies. This episode is a journey into the foundational challenges of aging science, highlighting the need for robust, translational research strategies. Join us for a riveting discussion that promises to enlighten, challenge, and inspire our understanding of the path forward in aging research.

BUFFALO, NY- January 3, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 24, entitled, “Mapping of the gene network that regulates glycan clock of ageing.” Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but only a few were functionally validated. One of the key functional features of IgG glycosylation is the addition of galactose (galactosylation), a trait which was shown to be associated with ageing. In this new study, researchers Azra Frkatović-Hodžić, Anika Mijakovac, Karlo Miškec, Arina Nostaeva, Sodbo Z. Sharapov, Arianna Landini, Toomas Haller, Erik van den Akker, Sapna Sharma, Rafael R. C. Cuadrat, Massimo Mangino, Yong Li, Toma Keser, Najda Rudman, Tamara Štambuk, Maja Pučić-Baković, Irena Trbojević-Akmačić, Ivan Gudelj, Jerko Štambuk, Tea Pribić, Barbara Radovani, Petra Tominac, Krista Fischer, Marian Beekman, Manfred Wuhrer, Christian Gieger, Matthias B. Schulze, Clemens Wittenbecher, Ozren Polasek, Caroline Hayward, James F. Wilson, Tim D. Spector, Anna Köttgen, Frano Vučković, Yurii S. Aulchenko, Aleksandar Vojta, Jasminka Krištić, Lucija Klarić, Vlatka Zoldoš, and Gordan Lauc from Genos Glycoscience Research Laboratory, University of Zagreb, Novosibirsk State University, Lomonosov Moscow State University, University of Edinburgh, University of Tartu, Leiden University Medical Center, Delft University of Technology, Helmholtz Zentrum Muenchen, German Center for Diabetes Research (DZD), King's College London, Guy's and St Thomas' Foundation Trust, University of Freiburg, University of Rijeka, German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam, Harvard T.H. Chan School of Public Health, Chalmers University of Technology, University of Split School of Medicine, Algebra University College, Johns Hopkins Bloomberg School of Public Health, and Institute of Cytology and Genetics SB RAS performed GWAS of IgG galactosylation (N=13,705) and identified 16 significantly associated loci, indicating that IgG galactosylation is regulated by a complex network of genes that extends beyond the galactosyltransferase enzyme that adds galactose to IgG glycans. “Here, we conducted a GWAS of IgG galactosylation phenotypes in a study that almost doubles the sample size (N=13,705) compared to previous GWAS of IgG N-glycome [33] and focused on the genes with in silico evidence for involvement in the IgG galactosylation process.” Gene prioritization identified 37 candidate genes. Using a recently developed CRISPR/dCas9 system, the researchers manipulated gene expression of candidate genes in the in vitro IgG expression system. Upregulation of three genes, EEF1A1, MANBA and TNFRSF13B, changed the IgG glycome composition, which confirmed that these three genes are involved in IgG galactosylation in this in vitro expression system. “Further research is needed to fully elucidate [the] functional mechanism behind their role in ageing and to reveal the complete network of gene interactions regulating the complex process of IgG glycosylation.” DOI - https://doi.org/10.18632/aging.205106 Corresponding authors - Azra Frkatović-Hodžić - afrkatovic@genos.hr, and Gordan Lauc - glauc@genos.hr Visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

Alert: A Must Hear. New COVID Variant Very Deadly to Vaccinated. Prepare Now. Buy Ivermectin, Hydroxychloroquine, etc. Now.   To watch the entire 1:37 minute interview visit- https://www.youtube.com/live/EoMH2R0vVxM?si=9qrW6pdyUYNKTl1I Geert's Concern about the New Covid Variant (JN.1) Vejon Health 95.6K subscribers 83,098 views Streamed live on Dec 21, 2023 #CovidVaccines #COVID19 #covid Dr. Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer. He then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager and subsequently joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. Geert is now primarily serving as a Biotech/Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines. Website: https://www.voiceforscienceandsolidar...  Latest news, research and updates about COVID-19 and health. Join on Substack: https://philipmcmillan.substack.com/ Join on Patreon:   / vejonhealth   #COVID19 #CovidVaccines FREE and Paid Courses Available! https://mcmillanresearch.com/mr-educa... Watch videos at McMillan Research: https://mcmillanresearch.com/media/ #covid #medicine #research Transcript available at: https://www.youtube.com/live/EoMH2R0vVxM?si=9qrW6pdyUYNKTl1I

Birds and mindfulness is the topic of today's episode. You might remember me telling you about planting various flowers around my house and how having plants around me adds to the mindfulness in my life. Well, back in May, I made a new flower bed just for Black-Eyed Susans. Every time I look out our big window into the backyard, I see the beautiful bright yellow-orange flowers. Well this episode isn't about flowers, it's about birds, but they are closely related, at least in my mind. When I got married, I discovered my new in-laws were avid bird-watchers. When my wife and I would visit my mother-in-law and sister-in-law, we'd be deep in conversation, and suddenly everyone would run to the window to see a specific kind of bird that had appeared at the bird feeder. The conversation would be immediately redirected. This was all new for me. In the past, my wife's aunt June would watch and count birds for certain organizations, I think, BirdLife International or Birdcount.org. I was always amazed that she knew about and could identify dozens and probably hundreds of different birds. Listen & Subscribe on: iTunes / Stitcher / Podbean / Overcast / Spotify The Joy From Birds A growing body of scientific evidence also shows that the joy delivered by birds is real. Research increasingly links exposure to nature—and specifically, exposure to birds—with improved well-being. In December, a new study by the German Center for Integrative Biodiversity Research connected greater bird biodiversity to increased life-satisfaction for more than 26,000 people in 26 European countries. It turns out the people who live near natural areas with a greater diversity of bird species were simply happier. In fact, the study found that seeing 10 percent more bird species generates satisfaction on par with a comparable increase in income. Birds Can Do This seeing and hearing birds can improve well-being. Bird exposure is effective for those suffering with depression, or without. Birds can bring longer-lasting psychological, intellectual, and social well-being. 5 Ways Noticing Birds Can Boost Mindfulness. Heightened Awareness: Noticing birds in your surroundings encourages you to be more present and attentive to the environment. It helps you cultivate a sense of mindfulness by focusing your attention on the present moment and the natural world around you. Deepening Observation Skills: Birdwatching requires keen observation skills, such as noticing different colors, patterns, behaviors, and sounds. Engaging in this practice sharpens your ability to observe details and enhances your overall mindfulness. Connection to Nature: Birds are an integral part of the natural ecosystem, and observing them can deepen your connection to nature. By being aware of their presence and interactions, you develop a sense of interconnectedness with the environment, promoting a mindful and appreciative mindset. Cultivating Curiosity: Birdwatching often sparks curiosity and a sense of wonder about the natural world. As you observe different bird species, you may find yourself seeking knowledge, researching their behaviors, habitats, and characteristics. This curiosity fosters an inquisitive and mindful mindset. Engaging the Senses: Birdwatching stimulates multiple senses, such as sight, sound, and sometimes even touch. Paying attention to the melodies, calls, and movements of birds can create a sensory-rich experience that draws you into the present moment and cultivates mindfulness through sensory awareness. Suggested Resources Website: Birdlife International Website: The Great Backyard Bird Count Book: Bird Therapy by Joe Harkness and Chris Packham Book: Silent Spring by Rachel Carson App: Bird Sounds, Listen and Relax Words of Wisdom I suggest we allow birds to help guide us into a deeper state of presence, serenity, and connection. Notice the melodies of their songs and the graceful and almost miraculous way they effortlessly fly around above us. Let birds be a constant reminder of the beauty and peace that surrounds us, inviting us to live fully in each moment with mindfulness and appreciation. And remember the black-eyed Susans I planted in the backyard? Just yesterday, I looked out there and saw two yellow finches having a great time drinking nectar from the flowers, flitting around, and looking like they were in heaven. That in itself was a gift of mindfulness. Related Episodes Nature and Mindfulness Weekends With Bruce Langford and Hilde Larsen Pause, Breathe, And Smile To Awaken Your Mindfulness; Gary Gach Reclaim Your Health and Freedom With A Walking Life; Antonia Malchik Special Offer Are you experiencing anxiety & stress? I'm Bruce Langford, a practicing hypnotist helping fast-track people just like you to shed their inner bully and move forward with confidence. Book a Free Session to get you to a more satisfying life, feeling grounded and focused. Send me an email at bruce@mindfulnessmode.com with ‘Let's Talk' in the subject line. We'll set up a call and talk about how you can move forward to a better life.

Are we facing a healthcare tragedy? Geert Vanden Bossche. Book- The Inescapable Immune Escape Pandemic. Last year we had our first conversation with virologist Dr. Geert Vanden Bossche. Already two years ago, this brilliant scientist warned about the possible negative effects of mass vaccination during a pandemic. Unfortunately, just about all of his predictions have come true so far. Earlier this week, his book "The Inescapable Immune Escape Pandemic" was published. So it was time for a second interview and we are sure you will learn a lot this time as well. His book provides a thought-provoking analysis of the complex interactions between the virus and the host immune system that underlie the evolution of the COVID-19 pandemic. The author delves into the impact of mass vaccination on individual and global health, and explains how powerful organizations, institutions, and industries lacking an understanding of this complex environment have turned a natural viral pandemic into one of disastrous immune escape. The author's predictions are compelling and indicate that Nature will correct this mistake, but at a substantial cost to human lives in highly vaccinated countries. The book also highlights the ignorance and arrogance of key opinion leaders and decision-makers in the field as the main reason for this colossal blunder. It is a must-read for anyone interested in understanding the intricacies of the pandemic and the impact of mass vaccination on society. The author's unique approach and reliance on basic scientific principles make this a valuable addition to the literature on the subject. Dr. Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer. He then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager and subsequently joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. 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Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer, he then worked with the Global Alliance for Vaccines and Immunization (GAVI) ============================== Please Consider Donating so I may Continue to Create FREE Content https://www.awakeningpodcast.org/support/ ========================================== Freedom Broadcaster Livestream On April 27, 2023 Grace from Start to 26:55 & 1:05 to finish Roy From 26:55 to 49:50 Jayne from 49:50 to 1:05 Guest: Dr. Geert Vanden Bossche Topic:  The Inescapable Immune Escape PandemicBook: The Inescapable Immune Escape Pandemic Bio: Dr. Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager and subsequently joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. Geert is now primarily serving as a Biotech/ Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines. As a creative thinker, innovator, entrepreneur and visionary, Geert has been invited to speak at multiple international congresses. His work and supportive advice are driven by a relentless passion to translate scientific breakthrough findings into competitive solutions to emerging challenges in public and global health. Dr. Vanden Bossche has become world famous for warning Humanity against the health danger of conducting mass vaccination programs during a pandemic (March 2021). What we Discussed: - How is his family and circle of friends regarding the jab - What is a Natural Pandemic - Innate immunity - None of the measure that the authorities introduced make sense - Does he know that the Gates foundation and WHO know that Vaccines don't work - The WHO depends on Sponsors and its problems - Why were Dr's and Hospitals Incentivised to put patients on ventilators - Studies prove that the measures were wrong to lockdown and mask - I (Roy) do not believe any vaccine work with all the toxins - Natural things to build your immunity - Why the Vaccines should stop - How critical mass can make change - Hes against the yearly flu vaccine - Children should not be getting so many vaccine's at a young age and more Interview Panel Grace Asagra, RN MA (Holistic Nurse, US, originally from the Phil)Podcast:  Quantum Nurse: Out of the Rabbit Hole from Stress to Bless⁠ www.quantumnurse.life⁠ TIP/DONATE LINK for Grace Asagra  @ Quantum Nurse Podcast https://patron.podbean.com/QuantumNurse Dr. Jayne Marquis, ND Podcast: INpowered https://linktr.ee/INpoweredhealth Roy Coughlan Podcast: AWAKENING https://www.awakeningpodcast.org/ TIP/DONATE LINK for Roy Coughlan @ Awakening Podcast https://www.awakeningpodcast.org/support/ Dr. Geert Vanden Bossche : ⁠www.DrGeert.com⁠ ⁠http://substack.com/profile/57302394-geert-vanden-bossche⁠ Book https://www.amazon.com/Inescapable-Immune-Escape-Pandemic/dp/1956257691?asin=B0C1NZ16L1&revisionId=c516639f&format=1&depth=1⁠ More about Roy: All Podcasts + Coaching and Social Media https://bio.link/podcaster https://awakeningpodcast.org/ Donations  https://www.awakeningpodcast.org/support/ Video https://www.bitchute.com/channel/y2XWI0VCPVqX/ https://rumble.com/user/Awakening

Quantum Nurse www.quantumnurse.life presents Freedom International Livestream On April 27, 2023 Thursday @ 12:00 PM EST 5:00 PM UK 6:00 PM Germany Guest: Dr.Geert Vanden Bossche Topic:  The Inescapable Immune Escape Pandemic   www.DrGeert.com http://substack.com/profile/57302394-geert-vanden-bossche   Bio: Dr. Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager and subsequently joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. Geert is now primarily serving as a Biotech/ Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines. As a creative thinker, innovator, entrepreneur and visionary, Geert has been invited to speak at multiple international congresses. His work and supportive advice are driven by a relentless passion to translate scientific breakthrough findings into competitive solutions to emerging challenges in public and global health. Dr. Vanden Bossche has become world famous for warning Humanity against the health danger of conducting mass vaccination programs during a pandemic (March 2021).   Book: The Inescapable Immune Escape Pandemic https://www.amazon.com/Inescapable-Immune-Escape-Pandemic/dp/1956257691?asin=B0C1NZ16L1&revisionId=c516639f&format=1&depth=1                 Interview Panel   TIP/DONATE LINK for Grace Asagra  @ Quantum Nurse Podcast https://patron.podbean.com/QuantumNurse https://www.paypal.com/donate/?hosted_button_id=FHUXTQVAVJDPU               Grace Asagra, RN MA (Holistic Nurse, US, originally from the Phil) Podcast:  Quantum Nurse: Out of the Rabbit Hole from Stress to Bless www.quantumnurse.life Quantum Nurse - Bichute https://www.bitchute.com/channel/nDjE6Ciyg0ED/ Quantum Nurse – Apple https://podcasts.apple.com/us/podcast/quantum-nurse-out-of-the-rabbit-hole-from-stress-to-bliss/id1522579988 Quantum Nurse Earth Heroes TVhttp://www.earthheroestv.com/categories/the-freedom-broadcasters?via=grace Quantum Nurse Rumble https://rumble.com/c/c-764837 Quantum Nurse Podbean https://graceasagra.podbean.com       Dr. Jayne Marquis, ND  Podcast: INpowered  https://linktr.ee/INpoweredhealth   Roy Coughlan Podcast: AWAKENING https://www.awakeningpodcast.org/   TIP/DONATE LINK for Roy Coughlan @ Awakening Podcast https://www.awakeningpodcast.org/support/

Met jullie maandelijkse steun maken wij jullie wereldbeeld completer!https://www.buzzsprout.com/1956185/supportDe Nederlandse vertaling (tekst) vind je op www.compleetdenkers.be.Last year we had our first conversation with virologist Dr. Geert Vanden Bossche. Already two years ago, this brilliant scientist warned about the possible negative effects of mass vaccination during a pandemic. Unfortunately, just about all of his predictions have come true so far. Earlier this week, his book "The Inescapable Immune Escape Pandemic" was published. So it was time for a second interview and we are sure you will learn a lot this time as well.His book provides a thought-provoking analysis of the complex interactions between the virus and the host immune system that underlie the evolution of the COVID-19 pandemic. The author delves into the impact of mass vaccination on individual and global health, and explains how powerful organizations, institutions, and industries lacking an understanding of this complex environment have turned a natural viral pandemic into one of disastrous immune escape. The author's predictions are compelling and indicate that Nature will correct this mistake, but at a substantial cost to human lives in highly vaccinated countries. The book also highlights the ignorance and arrogance of key opinion leaders and decision-makers in the field as the main reason for this colossal blunder. It is a must-read for anyone interested in understanding the intricacies of the pandemic and the impact of mass vaccination on society. The author's unique approach and reliance on basic scientific principles make this a valuable addition to the literature on the subject.Dr. Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer. He then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager and subsequently joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. Meer info:www.compleetdenkers.beSteun ons zodat we content kunnen blijven maken:http://steunactie.be/actie/steun-podcast-compleetdenkers-1/-25295Of koop ons een ☕️ https://www.buymeacoffee.com/compleetdenkersInterviewer: Steven Arrazola de OñateGastspreker: Geert Vanden BosscheCamera: anja coenen ⓢ & Finn FransenMontage: Finn Fransen & anja coenen ⓢSoundmixer: Finn FransenMuziek Compleetdenkers: Finn FransenDatum opname: 8 februari 2023#compleetdenkers #podcast #stevenarrazoladeonate #cocoenenfilms #finnfransen #anjacoenen #geertvandenbosscheSupport the show

Last week Adam Smith attended the 32nd Alzheimer Europe Conference in Bucharest, Romania. In this podcast Adam and his guests bring you highlights from the discussion and an informal chat around some of the issues being explored on the agenda. This week's guests are husband and wife team - Chris Roberts, Chair of the European Working Group of People with Dementia, Jayne Goodrick, Dementia Carers Count Advisory Member. We also have three fantastic early career researchers, Dr Joni Gilissen & Charlèss Dupont from Vrije Universiteit Brussel and Simone Felding from DZNE, German Center for Neurodegenerative Diseases. In this great show we not only get the highlights from our researchers, but we have the privilege of getting first-hand commentary from Chris and Jane, whose personal experience of living with dementia and its impact on their lives, provides a unique, thought provoking, often moving, and essential perspective. This year's conference was held under the motto “Building bridges”. As in previous years, this conference is one of the few in the diary that provides a great networking opportunity which brings together people with dementia, their carers, volunteers and staff of Alzheimer associations, policy makers, health and social care professionals, researchers, academics and industry representatives from all over Europe and beyond. It received over 300 abstracts for oral and poster presentations covering a broad range of topics, from fundamental science to care, diagnosis, policies, interventions, treatments and more. Links discussed in the show: Conference Website - https://bit.ly/3gm4eTo Conference hashtag - https://bit.ly/3Sn4ezT Alzheimer Europe Reports - https://bit.ly/3Srxo0V INTERDEM World Café 5th December 2022 - https://bit.ly/3Ttj9dk -- You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

This is a special episode for the German community in the Shanghai area. You learn about a complete flexpat career from university to retirement. Including all challenges, happiness, and fears along the way. Not only, but especially for Germans. Share this episode with your German friend! The German Center is a "home away from home" for German companies in China. Taicang is probably the "most German" city in China. Find the German Center Taicang here: https://www.germancentretaicang.com/en/ Find Marieke on LinkedIn https://www.linkedin.com/in/marieke-bossek-5a009159 WeChat: MariekeBossek Email: Marieke.Bossek@gctaicang.com

Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness. Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech / Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines. https://www.voiceforscienceandsolidarity.org/scientific-blog/predictions-gvb-on-evolution-c-19-pandemic  https://twitter.com/GVDBossche  HELP ME CROWDFUND MY GAMESTOP BOOK. Go to https://wen-moon.com to join the crowdfunding campaign and pre-order To The Moon: The GameStop Saga! If you haven't already and you enjoyed this episode, please subscribe to this podcast and our mailing list, and don't forget, my book, Brexit: The Establishment Civil War, is now out, you'll find the links in the description below. You can listen to the show on Spotify - https://open.spotify.com/show/5AYWZh12d92D4PDASG4McB?si=5835f2cf172d47cd&nd=1  Apple Podcasts - https://podcasts.apple.com/us/podcast/chatter/id1273192590  Google Podcasts - https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5wb2RpYW50LmNvL2NoYXR0ZXIvcnNzLnhtbA  And all major podcast platforms.  Watch Us On Odysee.com - https://odysee.com/$/invite/@TheJist:4   Sign up and watch videos to earn crypto-currency!  Buy Brexit: The Establishment Civil War - https://amzn.to/39XXVjq  Mailing List - https://www.getrevue.co/profile/thejist  Twitter - https://twitter.com/Give_Me_TheJist  Website - https://thejist.co.uk/  Music from Just Jim – https://soundcloud.com/justjim 

Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness. Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech / Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines.

In this episode of Talking Techniques, supported by Resolve BioSciences, we explore the realm of spatial biology, with a particular focus on the techniques involved in this approach to biological exploration, and the exciting insights gleaned from these techniques that have led to this approach being labeled Natures Method of the year 2020!  Stefano Pupe, Postdoctoral Researcher at German Center for Neurodegenerative Diseases, takes me through this field, revealing – amongst other fascinating insights – the neuroscience studies that can now be conducted on live mice to monitor their neurological cell expression profiles as they perform specific behaviors. We also discuss the potential immortality complexes that could be driving a large amount of investment into the field and highlight some of the challenges to watch out for when conducting spatial biology studies. ContentsIntroduction 00:00-02:20 The concept of spatial biology 02:20-03:30 The key techniques involved in spatial biology: 03:30-05:10 What does the combination of transcriptomics and proteomic profiling enable you to determine: 05.10-06:00 Unique insights from spatial biology: 06:10-07:20 Spatial biology in the characterization of cells from the medial septal: 07:20-8:20 First impressions of working with spatial biology: 8:10-09:20 How many omic datasets you can generate from one tissue sample? 09:20-10:45 The impact of spatial biology in diagnostics: 10:45-11:50 Exciting breakthroughs in neuroscience from spatial biology: 11:50-14:00 Predicting neuronal activity with spatial data: 14:00-15:55 Developments in microscopy pairing with spatial biology: 15:55-18:05 The challenges of working with a new technique: 18:05-19:45 The role of automation in resolving with vast data sets 19:45-21:45 Why Facebook and Google are looking assisting with spatial biology: 21:45-24:15 What would you ask for to take spatial transcriptomics to the next level? 24:15-25:40 Challenges of reproducibility in an emerging field: 25:40-29:05 Final comments: 29:05-30:25

In this episode of Talking Techniques, supported by Resolve BioSciences, we explore the realm of spatial biology, with a particular focus on the techniques involved in this approach to biological exploration, and the exciting insights gleaned from these techniques that have led to this approach being labeled Natures Method of the year 2020! Stefano Pupe, Postdoctoral Researcher at German Center for Neurodegenerative Diseases, takes me through this field, revealing – amongst other fascinating insights – the neuroscience studies that can now be conducted on live mice to monitor their neurological cell expression profiles as they perform specific behaviors. We also discuss the potential immortality complexes that could be driving a large amount of investment into the field and highlight some of the challenges to watch out for when conducting spatial biology studies. ContentsIntroduction 00:00-02:20 The concept of spatial biology 02:20-03:30 The key techniques involved in spatial biology: 03:30-05:10What does the combination of transcriptomics and proteomic profiling enable you to determine: 05.10-06:00Unique insights from spatial biology: 06:10-07:20Spatial biology in the characterization of cells from the medial septal: 07:20-8:20First impressions of working with spatial biology: 8:10-09:20How many omic datasets you can generate from one tissue sample? 09:20-10:45The impact of spatial biology in diagnostics: 10:45-11:50 Exciting breakthroughs in neuroscience from spatial biology: 11:50-14:00Predicting neuronal activity with spatial data: 14:00-15:55 Developments in microscopy pairing with spatial biology: 15:55-18:05The challenges of working with a new technique: 18:05-19:45The role of automation in resolving with vast data sets 19:45-21:45Why Facebook and Google are looking assisting with spatial biology: 21:45-24:15What would you ask for to take spatial transcriptomics to the next level? 24:15-25:40Challenges of reproducibility in an emerging field: 25:40-29:05Final comments: 29:05-30:25 See acast.com/privacy for privacy and opt-out information.

Chronobiology is the study of biological rhythms. The human circadian system is a biological process known to regulate the sleeping and waking cycle (circadian rhythm; CR). Components of the circadian system are known as ​​clock genes. Clock genes generate daily oscillations of gene expression and interact as an intricate network to influence biological processes in organisms, tissues and cells. This system is primarily regulated by Earth's day and night cycles (light and darkness), though it can be affected by other factors, including nutrition, cellular devices, stress, illness, jet lag, and aging. “It is well established that aging interferes with the regulation of the circadian system, which, in return, contributes to the manifestation and progression of aging-related diseases (reviewed in [4, 5]).” Across an organism's lifespan, changes in circadian rhythm take place. These changes can cause aging-related diseases to become more prevalent. Studies have also shown that age-independent alterations in the circadian system can result in premature aging. This interrelation between aging and CR means that aging may play a role in the circadian system and that the circadian system may play a role in aging. However, researchers have not yet fully illuminated the impact of aging-related circadian system changes on healthy organs and tissues. “Whether aging-related changes of the circadian system's regulation follow a conserved pattern across different species and tissues, hence representing a common driving force of aging, is unclear.” In an effort to identify circadian rhythm regulatory patterns over the course of aging, researchers—from Friedrich Schiller University Jena, FLI Leibniz Institute for Age Research, Jena University Hospital, German Center for Integrative Biodiversity Research, and European Virus Bioinformatics Center—performed inter-species and inter-organ transcriptional analyses. The research paper was published in December of 2021 as the cover of Aging (Aging-US) Volume 12, Issue 24, and entitled, “Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.” Full blog - https://www.impactjournals.com/journals/blog/aging/aging-and-circadian-rhythm-does-a-conserved-link-exist/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203788 DOI - https://doi.org/10.18632/aging.203788 Full Text - https://www.aging-us.com/article/203788/text Correspondence to: Emanuel Barth email: emanuel.barth@uni-jena.de Keywords: aging, circadian clock system, circadian rhythm, inter-species comparison, longevity, RNA-Seq About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Courageous Convos is a weekly live webinar hosted by Voices For Freedom co-founders (Claire, Alia & Libby) with international guest, Dr. Geert Vanden Bossche. The former pharma, Gates Foundation, GAVI, and WHO insider spoke with us about his public concerns about the vaccine, the potential for virus mutation, and the possible consequences. Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness. Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech/ Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines. Geert was interviewed live on 11 October 2021. Remember to sign up to our mailing list to keep informed: www.voicesforfreedom.co.nz/stay-informed/ For more podcasts on these and other topics relating to upholding our freedoms join Claire, Libby and Alia at VOICES FOR FREEDOM - https://voicesforfreedom.co.nz

‘Covid Vaccinations in Children Will Lead to a Tsunami of Autoimmune Diseases. Under No Conditions Should We Vaccinate Any Child.'- Dr. Geert Vanden Bossche PhD “Very Seriously, Very Seriously, I am convinced that immunizing young children will lead to a tsunami of autoimmune diseases…” “We cannot, we should not, under no conditions should we vaccinate any child…” Dr. Geert Vanden Bossche. https://youtu.be/AWbhMSMAwPE 5,745 views Vejon Health 31.9K subscribers The recent decision to approve vaccines in the 5 - 11 year old groups has caused concern among some parents. Others have welcomed the news and look at this as another step in the process to stop the COVID-19 pandemic. Usually childhood vaccines take many years to be approved. What are the perspectives of a vaccine developer who has worked in the industry for many decades. Listening to the thoughts of Geert Vanden Bossche should be instructive for scientists and the general public. Want to understand the fundamentals of COVID? Try our COVID-19 Foundation 360 course. Click link below. https://mcmillanresearch.com/covid-19...   Geert Vanden Bossche (DVM, PhD) Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness. Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech/ Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines.

‘Covid Vaccinations in Children Will Lead to a Tsunami of Autoimmune Diseases. Under No Conditions Should We Vaccinate Any Child.'- Dr. Geert Vanden Bossche PhD “Very Seriously, Very Seriously, I am convinced that immunizing young children will lead to a tsunami of autoimmune diseases…” “We cannot, we should not, under no conditions should we vaccinate any child…” Dr. Geert Vanden Bossche. https://youtu.be/AWbhMSMAwPE 5,745 views Vejon Health 31.9K subscribers The recent decision to approve vaccines in the 5 - 11 year old groups has caused concern among some parents. Others have welcomed the news and look at this as another step in the process to stop the COVID-19 pandemic. Usually childhood vaccines take many years to be approved. What are the perspectives of a vaccine developer who has worked in the industry for many decades. Listening to the thoughts of Geert Vanden Bossche should be instructive for scientists and the general public. Want to understand the fundamentals of COVID? Try our COVID-19 Foundation 360 course. Click link below. https://mcmillanresearch.com/covid-19...   Geert Vanden Bossche (DVM, PhD) Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation's Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness. Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech/ Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines.

Sept 2021 You're listening to the September episode of 3 Minute 3Rs. The papers behind the pod: Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Scientific Reports 11, 6403 (2021) https://doi.org/10.1038/s41598-021-85708-2 Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations Brain and Neuroscience Advances (2021) https://doi.org/10.1177/23982128211036332 O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)—an RFID-based tracking system. Behavior Research Methods (2021) https://doi.org/10.3758/s13428-021-01593-7 [Transcript] It's the 3rd Thursday of September, and you're listening to 3 Minute 3Rs, your monthly recap of efforts to replace, reduce, and refine the use of animals in research. This month, we've got a paper for each R. Let's get started with a replacement. NA3RsC Drug induced liver injury in clinical trial and for newly approved drugs is a serious adverse reaction that causes massive financial loss and preventable human suffering. But what if we could more accurately predict these adverse reactions before they happened? A systematic review in Scientific Reports compared two anti-diabetic drugs, one that was withdrawn from the market due to liver injuries and another that remains. They reviewed in vivo studies, in vitro data, and reported liver injury cases. While the animal and human trials failed to predict liver injuries, the in vitro assays showed the withdrawn drug had twice the activity than the other. Overall, in vitro assays may offer a new paradigm to predict drug induced liver injuries thereby improving drug safety and development. Want to learn more? Read the full paper online. Next let's reduce... NC3Rs If you want to know where you're going, an atlas can help – and now, if you're performing rodent stereotaxic surgery, Ratlas can help! Lister hooded rats are widely used in behavioural neuroscience studies in the UK and beyond. When these studies involve stereotaxic surgery, accurate coordinates are vital for precisely targeting the relevant areas of the brain – otherwise, additional animals may be used for pilot surgeries to establish the correct coordinates. To reduce the need for these pilot surgeries, ­researchers at the University of Nottingham and Leibniz Institute for Neurobiology have developed Ratlas-LH, a user-friendly template combining in vivo MRI images and ex vivo micro-CT images of young adult male Lister hooded rats. The team have published a paper describing the development and validation of Ratlas-LH, and aim to expand their work to other commonly used rat and mouse strains. Interested? Read the paper in Brain and Neuroscience Advances and download Ratlas-LH for free. And finally, let's refine: Lab Animal Most mice will spend most of their time just hanging out in the comfort of their home cages. Providing simple husbandry refinements there can go a long way for the animals' welfare, but what do mice want? Why not ask them? A new home cage device from researchers at the German Center for the Protection of Laboratory Animals aims to do just that. Dubbed the Mouse Position... See acast.com/privacy for privacy and opt-out information.

Two Top Virologists' Frightening Warnings About COVID Injections: Ignored by Government and Big Media By Joel S. Hirschhorn NOQ Report, August 21 2021     When two great minds come to similar conclusions about the current global push to vaccinate everyone with the COVID experimental vaccines, we should pay close attention.  Both highly experienced scientists have a totally negative view of the vaccination effort.  Worse than being ineffective, they point to negative health outcomes for the global population.  These two truth-telling acclaimed medical researchers make Fauci look as inept, deceitful and dangerous as he is. The point made in this article is not only has Fauci pushed the wrong potentially disastrous pandemic solution, he has blocked the right one. Much of what the two virologists say is very technical in nature.  This article simplifies their controversial messages without losing their essential meanings.  The public needs to understand their warnings that refute all the propaganda pushing vaccines from government and public health agencies as well as big media. Warning: Keep reading and you may become depressed. * Dr. Luc Montagnier First considered is the thinking of Dr. Luc Montagnier, a French virologist and recipient of the 2008 Nobel Prize in Medicine for his discovery of the human immunodeficiency virus (HIV).  He has a doctorate in medicine.  But there is a lot more to conclude he is a great expert: He has received more than 20 major awards, including the French National Order of Merit and the Légion d'honneur.  He is a recipient of the Lasker Award, the Scheele Award, the Louis-Jeantet Prize for medicine , the Gairdner Award  the Golden Plate Award of the American Academy of Achievement, King Faisal International Prize (known as the Arab Nobel Prize), and the Prince of Asturias Award. He has worked hard to expose the dangers of the COVID-19 vaccines, still experimental but sadly may soon be fully approved.  The vaccines don't stop the virus, argues the prominent virologist, they do the opposite — they “feed the virus,” and facilitate its development into stronger and more transmittable variants.  These new virus variants will be more resistant to vaccination and may cause more health implications than their “original” versions. Montagnier refers to the mass vaccine program as an “unacceptable mistake” and are a “scientific error as well as a medical error.”  His assertion is that “The history books will show that…it is the vaccination that is creating the variants.”  In other words: “There are antibodies, created by the vaccine,” forcing the virus to “find another solution” or die.  “This is where the variants are created.  It is the variants that “are a production and result from the vaccination.”  Stop and think about these thoughts.  Have you heard a better explanation of variant creation?  I doubt it. He is talking about the mutation and strengthening of the virus from a phenomenon known as Antibody Dependent Enhancement (ADE).  ADE is a mechanism that increases the ability of a virus to enter cells and cause a worsening of the disease. Data from around the world confirms ADE occurs in SARS-CoV-2, which causes COVID-19, says Montagnier. “You see it in each country, it's the same: the curve of vaccination is followed by the curve of deaths.”  Sounds like what we are now hearing more about, namely escalating breakthrough infections that kill some people.  And this spiral into disaster may have no end. In a November 2020 documentary he emphasized harmful and irrational mask mandates as well as lockdowns, quarantines, abuses of government overreach, and supported use of effective COVID treatments such as hydroxychloroquine.  The film was banned by YouTube and most other mainstream outlets.  At that time Fauci had succeeded in blocking wide use of the cheap generic based treatments for COVID and pursued the wait for the vaccine strategy. Montagnier has been a vocal critic of the mass vaccination campaign.  In a letter to the President and Judges of the Supreme Court of the State of Israel, which unrolled the world's speediest and the most massive vaccination campaign, Montagnier argued for its suspension.  He said: “I would like to summarize the potential dangers of these vaccines in a mass vaccination policy.”  Here they are: 1. Short-term side effects: these are not the normal local reactions found for any vaccination, but serious reactions involve the life of the recipient such as anaphylactic shock linked to a component of the vaccine mixture, or severe allergies or an autoimmune reaction up to cell aplasia.  In this group we should include a number of lethal blood problems involving clots and loss of platelets that cause strokes, brain bleeds and other impacts. Lack of vaccine protection: 2.1 In induced antibodies do not neutralize a viral infection, but on the contrary facilitate it depending on the recipient.  The latter may have already been exposed to the virus asymptomatically.  Naturally induced antibodies may compete with the antibodies induced by the vaccine. 2.2 The production of antibodies induced by vaccination in a population highly exposed to the virus will lead to the selection of variants resistant to these antibodies.  These variants can be more virulent or more transmissible.  This is what we are seeing now.  An endless virus-vaccine race that will always turn to the advantage for the virus. Long-term effects: Contrary to the claims of the manufacturers of messenger RNA vaccines, there is a risk of integration of viral RNA into the human genome. Our cells have the ability to reverse transcriptase from RNA into DNA. Although this is a rare event, its passage through the DNA of germ cells and its transmission to future generations cannot be excluded. His bottom line: “Faced with an unpredictable future, it is better to abstain.”  But most people will find it extremely difficult to resist all the coercion and vaccine mandates. Back in April 2020, before all the talk of variants and before the rollout of the experimental vaccines, Montagnier urged people to refuse vaccines against COVID-19 when they become available.  His main point should always be remembered: “instead of preventing the infection, they [would] accelerate infection.”  Today, the newly occurring variants of SARS-CoV-2 that affect vaccinated people prove his thesis.  With his scientific thinking, mass vaccination may cause a new, more deadly wave of pandemic infection. As to the much talked about and hope for herd immunity, he has said: “the vaccines Pfizer, Moderna, Astra Zeneca do not prevent the transmission of the virus person-to-person and the vaccinated are just as transmissive as the unvaccinated.  Therefore the hope of a ‘collective immunity' by an increase in the number of vaccinated is totally futile.” On the positive side, he advocated this: “The early treatment of infection with ivermectin and bacterial antibiotic because there is a bacterial cofactor that amplifies the effects of the virus. “ Dr. Vanden Bossche The stark views of Montagnier have been shared by the esteemed Belgium virologist Dr. Vanden Bossche.  He too has considerable credentials that make his views worth consideration.  He has PhD degree in Virology from the University of Hohenheim, Germany.  He held faculty appointments at universities in Belgium and Germany.  He was at the German Center for Infection Research in Cologne as Head of the Vaccine Development Office.  He has been in the private sector at several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) where he worked on vaccine R&D as well as vaccine development.  He also worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. His views have been analyzed in a recent article.  He too has loudly called for a halt to mass-vaccination programs.  He believes that if the jabs are not halted, they could lead to the evolution of stronger and stronger variants of the virus until a “supervirus” takes hold and wipes out huge numbers of people. This is his bold view: “Given the huge amount of immune escape that will be provoked by mass vaccination campaigns and flanking containment measures, it is difficult to imagine how human interventions would not cause the COVID-19 pandemic to turn into an incredible disaster for global and individual health.” Here is an essential element of his thinking.  Pretty much everything being done in the pandemic doesn't guarantee elimination of the virus.  What is happening is selective viral ‘immune escape' where viruses continue to be shed from those who are infected [both vaccinated and nonvaccinated] because neutralizing antibodies fail to prevent replication and elimination of the virus. The evolutionary selection pressure on the virus through ‘immune escape,' creates ever more virulent strains of the virus that have a competitive advantage over other variants and will increasingly have the potential to break through the antibody defenses.  Defenses provided by the vaccine induced immune system.  This is ‘vaccine resistance.'  What happens is that vaccine makers keep trying to outsmart variants, but fail.  So, they keep pushing boosters and yearly vaccine shots.  This is the more is better approach.  This is aided by suppression of many negative facts about the vaccines by big media. A frightening forecast by Bossche is that the worst of the pandemic is still to come.  Hard to believe considering all the bad news propaganda about cases, hospitalizations and deaths.  But he thinks we are now experiencing the calm before the ultimate storm.  Imagine a new wave of infection far worse than anything we've seen so far is how Bossche thinks. How does this happen?  There will be more mutants or variants to which the adaptive immune system from vaccine shots provides little resistance.  At the same time there will be decreased innate or natural immune effectiveness.  Unless people take a number of steps to boost their natural immunity. Bossche consistently points to a lack of evidence that the existing global, mass vaccination program that has been mounted while there is still significant infection around, is unprecedented and there is no scientific evidence that this will work.  This is why he is largely ignored. He stresses that historic vaccination programs have always emphasized the importance of vaccinating populations prophylactically in the absence of infection pressure. He also argues that if different types of vaccine were used that provided sterilizing immunity i.e., that prevented immune escape and killed all viruses in those vaccinated, the situation would be entirely different.  Most people do not understand that the current experimental vaccines do not actually kill the virus; and that both the vaccinated and nonvaccinated shed the virus.  These vaccines do not stop viral transmission.  And all the contagion control measures simply to not work effectively enough to stop wide spread of the virus in its various forms. Here is his big picture view: “There is only one single thing at stake right now and that is the survival of our human race, frankly speaking.” But there are more strong words recently said by Bossche to pay attention to: “every person out there who is ‘partially' or ‘fully' vaccinated is a walking disease incubation system that puts everyone else at risk of contracting a deadly, vaccine-caused ‘variant' that could kill them.  The ‘vaccinated' are walking murderers spreading disease to others.  Getting injected for the Fauci Flu is not only foolish; it is also a form of murder in that unvaccinated people are now at risk of contracting the deadly diseases being manufactured inside the bodies of the vaccinated.  If Trump had never introduced the vaccine in the first place, the pandemic would have long ago fizzled out.  Since his vaccines continue to be pushed … however, the ‘Delta' variant is spreading like wildfire, soon to be followed by other ‘variants' as we enter the fall season.” This too is a very strong view.  The “mass vaccination program is…unable to generate herd immunity.”  If true, there is little hope of seeing the COVID pandemic ending. What is the solution?  Bossche has identified the needed alternative to the current massive vaccine effort.  It is this; “This first critical step can only be achieved by calling an immediate halt to the mass vaccination program and replacing it by widespread use of antiviral chemoprophylactics while dedicating massive public health resources to scaling early multidrug treatments of Covid-19 disease.”  This is referring to the early home/outpatient treatment protocols based on cheap, safe and fully approved generics like ivermectin and hydroxychloroquine; these also work as preventatives.  Pandemic Blunder provides much data and advice on using this treatment approach.  So, both virologists support use of what Fauci has blocked. These action recommendations were also made by Bossche “Provide – at no cost – early multidrug treatment to all patients in need.  Roll out campaigns to promote healthy diets and lifestyle.”  In other words, people need to take actions to boost their natural immunity, this should include vitamins and supplements, including this cocktail: vitamin C, vitamin D, zine and quercetin. Conclusions Take a moment to consider that Patrick Wood on the Bannon show on August 21 concluded that all the available data from the US and Europe shows some 100,000 people have died from the COVID experimental vaccines.  I agree with that assessment.  And by the time you read this FDA may have given full approval to the Pfizer vaccine. After considering what these two experts have said it is appropriate to criticize what current government officials say, namely blame the unvaccinated for the surges in COVID cases, hospitalizations and deaths.  The major alternative to this thinking is that it is the vaccinated people who are creating pandemic problems, including the variants.  The strong conclusion is that the current vaccines are ineffective, nonprotective and dangerous. What is needed is an entirely new approach to COVID vaccines. Perhaps there are companies working on this.  This would threaten the trillion-dollar business of the current vaccine makers. If the people, agencies and institutions with all the power listening to these two very smart people they would devote all their energies to using alternatives to the current vaccines.  We have them.  Notably, the treatment protocols that so many great doctors have created and used to help their patients. Many other physicians and medical researchers have called for a halt to the current vaccine bonanza for big drug companies.  In the meantime, on a daily basis for all those willing to look at the facts, it is clearer and clearer that the experimental vaccines are not effective.  It is insanity to keep doing or expanding what is not working.  That is the insane world we are now experiencing even as more and people die from breakthrough infections, blood problems and other bad vaccine health impacts. Perhaps the ugly truth about the vaccines will be widely revealed only when there are massive, widespread deaths despite all the shots and jabs.  That will be too late to change pandemic management from money-driven stupidity to life-saving, medically moral actions. * Dr. Joel S. Hirschhorn, author of Pandemic Blunder and many articles on the pandemic, worked on health issues for decades.  As a full professor at the University of Wisconsin, Madison, he directed a medical research program between the colleges of engineering and medicine.  As a senior official at the Congressional Office of Technology Assessment and the National Governors Association, he directed major studies on health-related subjects; he testified at over 50 U.S. Senate and House hearings and authored hundreds of articles and op-ed articles in major newspapers.  He has served as an executive volunteer at a major hospital for more than 10 years.  He is a member of the Association of American Physicians and Surgeons and America's Frontline Doctors and has been a long-time contributor to the sites of Kettle Moraine.

Show Notes for Episode Nineteen of seX & whY: About Vaccine Research Host: Jeannette Wolfe Guests: Christine Dahlke, Biologist and vaccine researcher at University Medical Center Hamburg-Eppendor and The German Center for Infection Research Marylyn M Addo, Physician, Professor, Infectious disease specialist and vaccine researcher from University Medical Center Hamburg-Eppendor and The German Center for Infection Research Link to their paper: Sex Differences in Immunity: Implications for the Development of Novel Vaccines Against Emerging Pathogens Take-home points Vaccine development has evolved over the years from having each vaccine be independently developed “one drug for one bug” to “plug and play” platform technology in which a vector that predictably and effectively triggers the immune system is attached to a new pathogen's antigen (or mRNA or DNA that codes for that antigen), allowing for a much more accelerated development of new vaccines because researchers are not starting from scratch every time. Researchers often test antibody levels to determine vaccine efficacy but, immunization changes other aspects of the immune system such as t cell response and some innate immunity too. These changes may be more difficult to test but may also be important for long term protection even if antibody levels fall. Traditionally, drug companies have not been all that excited about developing vaccines due to the lack of a profit margin compared to a drug someone needs to take every day. The Coalition for Epidemic Preparedness Innovation (CEPI) helped jump start vaccine development in 2017 (apparently this was sparked by the realization that Ebola could have become a global pandemic and that we needed more tools to develop rapid turn- around vaccines.) Sex differences - due to sex hormones and chromosomes - influence how a body's innate and adaptative immune system works. Women generally having an advantage in fighting off infection by having a more robust innate and adaptative immune system. This may come at a cost of increased risk for autoimmune disease and in Covid, women are also much more likely to have long haul Covid symptoms. Age can act as an additional confounder with males having more impaired antibody response and increased innate inflammatory responses with age Most immune cells have sex steroid receptors on them Many genes that influence the immune system are housed on the X chromosome and some of them like Toll-like receptor 7 - aka the Paul Revere of the early immune response, may not undergo X-inactivation leading to it's over expression in females and possibly giving them an advantage in decreasing their viral load compared to males after similar exposures. Other references: Paper referred in podcast about Dr Klein: Bishof E, Wolfe J, Klein S - Clinical trials for COVID-19 should include sex as a variable. Podcast from last summer with my interview with Evelyn Bishof and Sabra Klein about Sex Differences in Immunology and Drug Therapy Herpes vaccine trial showing efficacy in females and not in males. Here are some videos on the immune system: Dr Iwasaki Made Easy New York Times article nicely explaining how different vaccines work

This is the fourth part of our CoG analysis for the Battle of France series. We discuss the Center of Gravity for Germany.  An interesting case as the Strategic Center of Gravity was unable to defeat France, so the Wehrmacht developed a highly risky operational Center of Gravity to defeat France in just 46 days - something that they could not achieve in all of WW1. How did the German's temporally dislocate themselves at the Strategic level? How could they avoid the nightmare of a two front war? Would they succumb to the siren song of the Schlieffin Plan and a quick win with all the risk that entails? Thank you to the British Army's Lessons Exploitation Centre for the assistance with getting the resources for this podcast series. Check out the show notes for the podcast for all of the information that we cover in this episode as well as the images and other details that didn't make it into the podcast. Join the conversation on Twitter or Facebook.

Lycopene is a promising nutrient that can prevent gastric diseases associated with H. pylori Yonsei University (Japan), April 30, 2021 Helicobacter pylori is a spiral-shaped bacterium that grows in your digestive tract. An opportunistic pathogen, it is considered to be the most successful colonizer of the human gastrointestinal tract, infecting the stomachs of roughly 60 percent of the world’s adult population. In a recent study, researchers at Yonsei University in South Korea found that lycopene, a bioactive pigment with powerful antioxidant properties, can help prevent gastric diseases associated with H. pylori infection. Lycopene is a non-provitamin A carotenoid commonly found in bright red and orange produce, such as tomatoes, watermelons, papaya and pink grapefruit. This beneficial compound is extensively studied for its remarkable ability to scavenge free radicals, the unstable byproducts of cellular metabolism responsible for causing oxidative stress. How lycopene prevents H. pylori-induced gastric cancer According to studies, H. pylori infection promotes the hyperproliferation of gastric epithelial cells — the very cells that make up the stomach lining — by increasing the production of free radicals called reactive oxygen species (ROS). ROS then activates two signaling pathways — Wnt/B-catenin and JAK1/Stat3 — that influence cell fate decisions. While Wnt/B-catenin signaling is involved in the regulation of the self-renewal processes of cells, JAK1/Stat3 signaling is said to play a role in conferring malignant properties to cancer cells. Due to the involvement of ROS, the South Korean researchers hypothesized that lycopene, which has antioxidant and anti-cancer properties, may be able to suppress H. pylori-induced hyperproliferation by inhibiting the activation of Jak1/Stat3 and Wnt/B-catenin signaling, as well as the expression of B-catenin target genes. B-catenin is a protein that accumulates due to the aberrant activation of Wnt/B-catenin signaling. The buildup of this protein promotes the expression of cancer genes (oncogenes) and the progression of tumors. In an earlier study published in The American Journal of Clinical Nutrition, German researchers reported that lycopene is the most effective scavenger of singlet oxygen, a very strong oxidant and one of the major ROS produced by cells. To determine if it can prevent ROS-mediated hyperproliferation, South Korean researchers treated H. pylori-infected gastric epithelial cells with lycopene.  They measured the cells’ ROS levels and viability before and after treatment. The researchers found that lycopene effectively reduced ROS levels and inhibited not only the activation of Jak1/Stat3 and Wnt/B-catenin signaling but also the expression of B-catenin target oncogenes and the proliferation of H. pylori-infected gastric epithelial cells. In addition, lycopene inhibited the increase in Wnt-1 (an oncogenic protein) and lipoprotein-related protein 5 (a protein involved in cancer progression) expression caused by H. pylori infection. Based on these findings, the researchers concluded that lycopene can be used to prevent H. pylori-associated gastric cancer, thanks to its inhibitory effects on gastric cell hyperproliferation.   Too much salt suppresses phagocytes Max Delbrück Center for Molecular Medicine (Germany), May 4, 2021 For many of us, adding salt to a meal is a perfectly normal thing to do. We don't really think about it. But actually, we should. As well as raising our blood pressure, too much salt can severely disrupt the energy balance in immune cells and stop them from working properly. Back in 2015, the research group led by Professor Dominik Müller of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Experimental and Clinical Research Center (ECRC) found that elevated sodium concentrations in the blood affect both the activation and the function of patrolling monocytes, which are the precursors to macrophages. "But we didn't know exactly what was happening in the cells," says Dr. Sabrina Geisberger of the Berlin Institute for Medical Systems Biology (BIMSB) at the MDC. She is lead author of the study of an international research team led by MDC scientists together with colleagues from University of Regensburg and from Flanders Institute for Biotechnology (VIB) /Hasselt University in Belgium. It was funded by the German Center for Cardiovascular Research (DZHK) and has now been published in the journal Circulation.  Salt disrupts the respiratory chain in cells Working with biochemist and metabolomics expert Dr. Stefan Kempa of BIMSB, the researchers began in the lab by looking at the metabolism of immune cells that had been exposed to high salt concentrations. Changes appeared after just three hours. "It disrupts the respiratory chain, causing the cells to produce less ATP and consume less oxygen," explains Geisberger. ATP (adenosine triphosphate) is the universal fuel that powers all cells. It provides energy for the "chemical work" - synthesizing proteins and other molecules - required for muscle power and metabolic regulation. ATP is produced in the mitochondria, the cell's "power plant," using a complex series of biochemical reactions known as the respiratory chain. "Salt very specifically inhibits complex II in the respiratory chain." This has consequences: The lack of energy causes the monocytes to mature differently. "The phagocytes, whose task is to identify and eliminate pathogens in the body, were able to fight off infections more effectively. But this could also promote inflammation, which might increase cardiovascular risk," explains Müller.  Effects of salt are reversible Professor Markus Kleinewietfeld of Hasselt University and VIB, and Professor Jonathan Jantsch of Universität Regensburg, were heavily involved in the work investigating human monocytes and macrophages. They were able to show that salt affects the functioning of human phagocytes in the same way. Researchers at the ECRC, which is run jointly by the MDC and Charité - Universitätsmedizin Berlin, then conducted a study in which healthy male participants supplemented their usual diets with six grams of salt in tablet form every day for 14 days. In another clinical study, the researchers investigated a familiar scenario: eating a pizza delivered by an Italian restaurant. They then analyzed the monocytes in the participants' blood. The findings showed that the dampening effect on mitochondria doesn't just occur after an extended period of increased salt intake - it also happens after a single pizza. Data from the pizza experiment showed how long the effect lasted: Blood was taken from the participants after three and eight hours, and the effect was barely measurable in the second sample. "That's a good thing. If it had been a prolonged disturbance, we'd be worried about the cells not getting enough energy for a long time," says Müller. The mitochondrial activity is therefore not permanently inhibited. That said, the continuous risk of sodium on mitochondrial function if a person eats very salty food several times a day cannot be ruled out, but needs to be tested in the future. The pizza, incidentally, contained ten grams of salt. Nutrition experts recommend that adults limit their daily intake to five or six grams at most. The calculation includes the salt that is hidden in processed foods. Small ion, big effect "The fundamental finding of our study is that a molecule as small as the sodium ion can be extremely efficient at inhibiting an enzyme that plays a crucial role in the respiratory chain," says Kempa. "When these ions flood into the mitochondria - and they do this under a variety of physiological conditions - they regulate the central part of the electron transport chain." It therefore appears to be a very fundamental regulatory mechanism in cells. Now the task is to investigate whether salt can also influence this mechanism in other types of cells. Kleinewietfeld believes that this is extremely likely because mitochondria aren't just present in immune cells; with the exception of red blood cells, they exist in every cell of the body. They can be found in particularly high numbers wherever a lot of energy is consumed - in muscle cells, neurons, receptors, and egg cells.  It is still not fully elucidated how different cell types regulate the influx of sodium into the mitochondria. Nevertheless, the study confirms that consuming too much salt can be bad for our health. "Of course the first thing you think of is the cardiovascular risk. But multiple studies have shown that salt can affect immune cells in a variety of ways. If such an important cellular mechanism is disrupted for a long period, it could have a negative impact - and could potentially drive inflammatory diseases of the blood vessels or joints, or autoimmune diseases," says Kleinewietfeld.     Ginkgo biloba extract improves cognitive function and increases neurogenesis by reducing amyloid beta pathology  Xuzhou Medical University (China), May 1, 2021 According to news reporting from Jiangsu, People’s Republic of China, research stated, “Previous studies have indicated that the generation of newborn hippocampal neurons is impaired in the early phase of Alzheimer’s disease (AD). A potential therapeutic strategy being pursued for the treatment of AD is increasing the number of newborn neurons in the adult hippocampus.” The news correspondents obtained a quote from the research from Xuzhou Medical University, “Recent studies have demonstrated that ginkgo biloba extract (EGb 761) plays a neuroprotective role by preventing memory loss in many neurodegenerative diseases. However, the extent of EGb 761’s protective role in the AD process is unclear. In this study, different doses of EGb 761 (0, 10, 20, and 30 mg/kg; intraperitoneal injections once every day for four months) were tested on 5xFAD mice. After consecutive 4-month injections, mice were tested in learning memory tasks, A beta, and neurogenesis in the dentate gyrus (DG) of hippocampus and morphological characteristics of neurons in DG of hippocampus. Results indicated that EGb 761 (20 and 30 mg/kg) ameliorated memory deficits. Further analysis indicated that EGb 761 can reduce the number of A beta positive signals in 5xFAD mice, increase the number of newborn neurons, and increase dendritic branching and density of dendritic spines in 5xFAD mice compared to nontreated 5xFAD mice.” According to the news reporters, the research concluded: “It was concluded that EGb 761 plays a protective role in the memory deficit of 5xFAD mice.” This research has been peer-reviewed.     Fasting lowers blood pressure by reshaping the gut microbiota Baylor College of Medicine, April 30 2021 Nearly half of adults in the United States have hypertension, a condition that raises the risk for heart disease and stroke, which are leading causes of death in the U. S. At Baylor College of Medicine, Dr. David J. Durgan and his colleagues are dedicated to better understand hypertension, in particular the emerging evidence suggesting that disruption of the gut microbiota, known as gut dysbiosis, can have adverse effects on blood pressure. "Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone rat) model, is different from that in animals with normal blood pressure," said Durgan, assistant professor of anesthesiology at Baylor. The researchers also have shown that transplanting dysbiotic gut microbiota from a hypertensive animal into a normotensive (having a healthy blood pressure) one results in the recipient developing high blood pressure. "This result told us that gut dysbiosis is not just a consequence of hypertension, but is actually involved in causing it," Durgan said. "This ground work led to the current study in which we proposed to answer two questions. First, can we manipulate the dysbiotic microbiota to either prevent or relieve hypertension? Second, how are the gut microbes influencing the animal's blood pressure?" Can manipulating the gut microbiota regulate blood pressure? To answer the first question, Durgan and his colleagues drew on previous research showing that fasting was both one of the major drivers of the composition of the gut microbiota and a promoter of beneficial cardiovascular effects. These studies, however, had not provided evidence connecting the microbiota and blood pressure. Working with the SHRSP model of spontaneous hypertension and normal rats, the researchers set up two groups. One group had SHRSP and normal rats that were fed every other day, while the other group, called control, had SHRSP and normal rats with unrestricted food availability. Nine weeks after the experiment began, the researchers observed that, as expected, the rats in the SHRSP control had higher blood pressure when compared to the normal control rats. Interestingly, in the group that fasted every other day, the SHRSP rats had significantly reduced blood pressure when compared with the SHRSP rats that had not fasted. "Next, we investigated whether the microbiota was involved in the reduction of blood pressure we observed in the SHRSP rats that had fasted," Durgan said. The researchers transplanted the microbiota of the rats that had either fasted or fed without restrictions into germ-free rats, which have no microbiota of their own. Durgan and his colleagues were excited to see that the germ-free rats that received the microbiota of normally fed SHRSP rats had higher blood pressure than the germ-free rats receiving microbiota from normal control rats, just like their corresponding microbiota donors. "It was particularly interesting to see that the germ-free rats that received microbiota from the fasting SHRSP rats had significantly lower the blood pressure than the rats that had received microbiota from SHRSP control rats," Durgan said. "These results demonstrated that the alterations to the microbiota induced by fasting were sufficient to mediate the blood pressure-lowering effect of intermitting fasting." How the microbiota regulates blood pressure The team proceeded to investigate the second question of their project. How does the gut microbiota regulate blood pressure? "We applied whole genome shotgun sequence analysis of the microbiota as well as untargeted metabolomics analysis of plasma and gastrointestinal luminal content. Among the changes we observed, alterations in products of bile acid metabolism stood out as potential mediators of blood pressure regulation," Durgan said. The team discovered that the SHRSP hypertensive animals that were fed normally had lower bile acids in circulation than normotensive animals. On the other hand, SHRSP animals that followed an intermittent feeding schedule had more bile acids in the circulation. "Supporting this finding, we found that supplementing animals with cholic acid, a primary bile acid, also significantly reduced blood pressure in the SHRSP model of hypertension," Durgan said. Taken together, the study shows for the first time that intermittent fasting can be beneficial in terms of reducing hypertension by reshaping the composition of gut microbiota in an animal model. The work also provides evidence that gut dysbiosis contributes to hypertension by altering bile acid signaling. "This study is important to understand that fasting can have its effects on the host through microbiota manipulation," Durgan said. "This is an attractive idea because it can potentially have clinical applications. Many of the bacteria in the gut microbiotaare involved in the production of compounds that have been shown to have beneficial effects as they make it into the circulation and contribute to the regulation of the host's physiology. Fasting schedules could one day help regulate the activity of gut microbial populations to naturally provide health benefits.   Study: Following healthy diets found to reduce the risk of acquired hearing loss by 30% Brigham and Women's Hospital, April 30, 2021 A study published in the American Journal of Epidemiology suggests that following a healthy diet may help ward off acquired hearing loss. A team led by Brigham and Women’s Hospital researchers examined middle-aged women and found that the odds of developing hearing loss is 30 percent lower in those who adhere to a healthy diet. Adherence to a healthy diet linked to lower risk of hearing loss Acquired hearing loss refers to the total or partial inability to hear sounds that develop after birth. It occurs for various reasons, including ear infection, meningitis, measles, head injury, exposure to loud noise and aging. Past studies linked higher intake of certain nutrients such as beta-carotene (found in carrots, legumes and other foods) and omega-3 fatty acids (found in fatty fish) to a lower risk of self-reported hearing loss. The researchers wished to learn more about this connection by tracking people’s diets and measuring changes in their hearing sensitivity over a long period of time. To do so, the researchers studied 20 years of dietary intake information from over 3,000 women with a median age of 59 who were included in the Nurses’ Health Study II. Using this information, they examined how closely the women’s long-term diets resembled the Alternate Mediterranean diet (AMED), Dietary Approaches to Stop Hypertension (DASH diet) and Alternate Healthy Index-2010 (AHEI-2010).  AMED is a version of the Mediterranean diet adapted to reflect eating patterns that are linked to a lower risk of chronic disease, while the DASH diet is intended to control and prevent high blood pressure. On the other hand, AHEI-2010 is based on the 2010 U.S. Department of Agriculture’s Dietary Guidelines for Americans and shares similar components with AMED and the DASH diet. Past studies linked adherence to these diets to a lower risk of heart disease, stroke, diabetes, hypertension and premature death. To measure the participants’ hearing sensitivity over the course of three years, the team put up 19 testing sites across the country and trained audiologists to measure changes in the participants’ pure-tone hearing thresholds – the lowest and highest pitch (frequency of a sound) that a person can detect in one ear. The researchers found that the odds of hearing loss in the mid-frequencies were nearly 30 percent lower in the women whose dietary patterns resembled the three diets, compared to those whose diets least resembled them. Meanwhile, the odds of hearing loss in higher frequencies were up to 25 percent lower. The frequencies encompassed in these associations, according to the researchers, are critical for speech understanding. “We were surprised that so many women demonstrated hearing decline over such a relatively short period of time,” said Sharon Curhan, a professor of medicine at Harvard Medical School and the lead researcher of the study. After only three years, nineteen percent of the participants had low-frequency hearing loss, 38 percent had mid-frequency hearing loss, while nearly half had high-frequency hearing loss. (Related: Age-related hearing loss halted with folate nutrient.) “The mean age of the women in our study was 59 years; most of our participants were in their 50s and early 60s. This is a younger age than when many people think about having their hearing checked,” she added. The researchers plan to continue tracking the participants with repeated hearing tests and are currently investigating ways to collect high-quality information for future studies across diverse populations.   Thai ginseng found to improve erectile function in men Life Extension Foundation, April 28, 2021 American researchers examined the effects of an ethanol extract derived from Kaempferia parviflora, also known as Thai ginseng, on erectile function in healthy middle-aged and older men. Their findings were published in the Journal of Integrative Medicine. Sexual health positively correlates with overall well-being. Current strategies that are meant to enhance male sexual health are limited by many factors, such as responsiveness, adherence and adverse effects. Researchers understand the need for safe and effective interventions that could help preserve male sexual function. K. parviflora, a plant from the Zingiberaceae (ginger) family, has been found to support cardiovascular health and has shown signs that it could ameliorate erectile dysfunction. To investigate this, the researchers conducted an open-label, one-arm study involving 14 generally healthy males aged 50 to 68 years with self-reported mild erectile dysfunction. The participants received 100 mg of an extract obtained from the rhizome of K. parviflora daily for 30 days. Primary efficacy analyses included the International Index of Erectile Function (IIEF), while secondary efficacy analyses included the Global Assessment Question about erectile function. The researchers reported that 13 of the 14 participants completed the study. Supplementation of the K. parviflora ethanol extract induced statistically significant improvements in erectile function, intercourse satisfaction and total scores on IIEF questionnaire. The extract was well-tolerated by the participants and exhibited an excellent safety profile. Based on these findings, the researchers concluded that K. parviflora can improve erectile function in healthy middle-aged and older men.     Curcumin Reduces Anxiety and Depression Even In People With Major Depression Texas Christian University and University of Arkansas, May 1, 2021   Dietary supplements formulated with highly bioavailable curcumin may allow for faster recovery after competition-level training, and blunt training-related decreases in performance , says new data presented at Experimental Biology.   Powdered turmeric has been used for centuries to treat a host of illnesses. It inhibits inflammatory reactions, has anti-diabetic effects, reduces cholesterol among other powerful healtheffects. A recent study led by a research team in Munich showed that it can also inhibit formation of metastases.  Dietary supplements formulated with highly bioavailable curcumin may allow for faster recovery after competition-level training, and blunt training-related decreases in performance , says new data presented at Experimental Biology. Using OmniActive's supplement ingredient, scientists reported that supplementation for eight weeks resulted in significant reductions in levels of creatine kinase, a marker of muscle damage, while self-reported pain scores were also significantly lower 24 hours post-exercise. A daily 200 mg dose of curcuminoids (in the form of 1,000 mg supplement) was also associated with a decrease in performance declines observed during "These data suggest that high dose bioavailable curcumin (200 mg curcuminoids) attenuates performance decrements following downhill running, eccentric loading, which may improve subsequent adaptations to chronic training," wrote the researchers in the FASEB Journal . Dr Ralf Jager from Wisconsin-based Increnovo and co-author on the study reports, explained that curcumin's sports nutrition benefits were linked to its antioxidant and anti-inflammatory potential. Muscle Damage Study The researchers recruited 59 moderately trained men and 29 women with an average age of 21 to participate in their double-blind, randomized, placebo controlled parallel design study. The participants were randomly assigned to receive 250 mg or 1,000 mg of supplement or placebo per day for eight weeks. The data indicated that, following muscle-damaging exercise, the high dose curcumin group experienced significantly lower pain scores, while increases in creatine kinase (CK) levels were also significantly reduced compared to placebo, when the baseline CK value is held constant at the mean. "These data demonstrate curcuminoids reduce muscle damage and improve muscle soreness in healthy young subjects following a bout of muscle damaging exercise. Faster recovery allows for consistent training at competition intensity and might lead to enhanced adaptation rate and performance," they wrote in the FASEB Journal . Performance A separate analysis was done with 62 men and women randomly assigned to 250 mg or 1,000 mg of supplement per day or placebo. After eight weeks the subjects performced downhill running, which promotes muscle damage. The results showed that performance declined significantly in both the placebo and low-dose curcumin group, but such declined were attenuated in the high-dose curcumin group. "Further study is warranted in other exercise types (i.e. resistance training) and chronically," wrote the researchers.

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy.  Becoming an Essentialist Prevent memory loss with a powerful nutrient in cucumbers Salk Institute for Biological Studies, February 16, 2021 The results of a recent study are offering new hope that avoiding memory loss related to aging as well as Alzheimer’s disease could be as simple as eating more cucumbers. Many older adults resign themselves to memory loss as part of the aging process. However, a study out of the the Salk Institute for Biological Studies has shown that this doesn’t have to be the case. The health benefits of cucumbers are many, and one of them seems to be better memory and even the prevention of Alzheimer’s disease. Researchers working with mice that normally developed the symptoms of Alzheimer’s (including memory loss) discovered that a daily dose of a flavonol called fisetin prevented these and other related impairments. This improvement occurred despite the continued formation of amyloid plaques, the brain proteins commonly blamed for Alzheimer’s. A natural food cure for memory loss The compound fisetin is found in numerous vegetables and fruits but is especially concentrated in strawberries and cucumbers. This flavonol is quite effective in stopping memory loss in mice and holds hope for humans as well. In the past, the main approach to treating Alzheimer’s symptoms was to target amyloid plaques in the brain. The findings of this study call into question the assumption that these proteins are largely responsible for the effects of Alzheimer’s. Even in animals with no signs of Alzheimer’s and otherwise normal functioning, fisetin has been shown to improve memory. However, its ability to prevent memory loss associated with Alzheimer’s disease could have profound implications for humans. Cucumbers protect the brain from inflammation Fisetin works by switching on a cellular pathway associated with the process of retrieving memories in the brain. Over a decade ago, other researchers discovered the compound fisetin assists in protecting the neurons of the brain from agingand its associated effects. It was found that this potent compound has both anti-inflammatory and antioxidant effects on brain cells. The list of health benefits of cucumbers, strawberries and other fruits and vegetables containing fisetin now include brain and memory improvements. By extension, fisetin has properties that can be highly beneficial for those at risk for Alzheimer’s. Other health benefits of cucumbers In addition to improving memory and potentially protecting against Alzheimer’s, the cucumber fruit has a range of additional nutritional and health benefits. They are low in calories (a cup of cucumbers contains just 16 calories) and assist in hydration (they are comprised of 95 percent water). They also provide flavonoids, triterpenes and lignans which offer anti-inflammatory, antioxidant and cancer-preventing benefits. The peel and seeds in cucumbers contain beta-carotene for eye health and are the most nutrient-dense portions of the fruit. Cucumber seeds contain calcium and the skin and seeds are also excellent sources of fiber. Other vitamins include potassium, vitamin C, magnesium and manganese.     Testosterone levels increased significantly after DHEA administration among older women Jiangxi University of Traditional Chinese Medicine, February 14, 2021 According to news originating from Jiangxi, People’s Republic of China, research stated, “Despite the fact that numerous clinical studies have evaluated the positive effects of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and on the body mass index (BMI), more evidence is needed to certify that DHEA is a BMI-reducing agent in the elderly. This meta-analysis aims to clarify the various incompatible results and investigate the impact of DHEA supplementation on serum testosterone levels and lean body mass in elderly women.” Our news journalists obtained a quote from the research from the Jiangxi University of Traditional Chinese Medicine, “Four scientific databases (EMBASE, PubMed/MEDLINE, Scopus and Web of Science) were searched from inception until 20 August 2020 for trials comparing DHEA with placebo. Results were presented as weighted mean differences (WMDs) and 95 % confidence intervals (CIs) based on the random effects model (DerSimonian-Laird approach). Nine arms with 793 subjects reported testosterone as an outcome measure. The overall results demonstrated that testosterone levels increased significantly after DHEA administration in elderly women (WMD: 17.52 ng/dL, 95 % CI: 6.61, 28.43, P = 0.002). In addition, DHEA administration significantly decreased the BMI (WMD:-0.39 kg/m(2), I-2 = 0.0 %).” According to the news editors, the research concluded: “The results of the current meta-analysis support the use of DHEA supplementation for increasing testosterone concentrations in elderly women.” This research has been peer-reviewed.   How healthy lifestyle behaviours can improve cholesterol profiles Harvard School of Public Health, February 15, 2021 Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife. Having a healthy lifestyle has long been associated with a lower risk of developing heart disease. The new study provides more detailed information on how healthy lifestyles improve cholesterol, and suggests that combining cholesterol-lowering medications and lifestyle interventions may yield the greatest benefits to heart health. Cholesterol-lowering medications such as statins help reduce heart risks by lowering levels of low-density lipoprotein (LDL) cholesterol, the so-called "bad" cholesterol. Healthy lifestyle interventions, including exercising regularly, having a healthy diet, lowering alcohol consumption and maintaining a healthy weight, have also been shown to lower LDL as well as increase "healthy" high-density lipoprotein (HDL) cholesterol. "Until now, no studies have compared the lipid-lowering effects of cholesterol-lowering medications and healthy lifestyle interventions side by side," says lead author Jiahui Si, Postdoctoral Research Fellow in the Department of Epidemiology at Harvard T.H. Chan School of Public Health, Boston, Massachusetts, US. To address this gap, Si and colleagues used a technique called targeted nuclear magnetic resonance spectroscopy to measure 61 different lipid markers in blood samples from 4,681 participants in the China Kadoorie Biobank, including cases of stroke, coronary heart disease and healthy individuals. They studied lipid markers in the blood of participants who had multiple healthy lifestyle habits and compared them to those of participants with less healthy habits. They found 50 lipid markers associated with a healthy lifestyle. When the team looked at a subset of 927 individuals who had coronary heart disease in the next 10 years and 1,513 healthy individuals, they found 35 lipid markers that showed statistically significant mediation effects in the pathway from healthy lifestyles to the reduction of heart disease. Together, the combined beneficial effects of the lipid changes associated with healthy lifestyle practices were linked to a 14% reduced risk of heart disease. Specifically, very-low-density lipoprotein (VLDL) and HDL levels in the blood were linked to the heart-protecting benefits of healthy lifestyles. "Using a genetic scoring technique, we could compare the effect of cholesterol-lowering drugs with that of lifestyle side by side in the study participants," says co-senior author Liming Liang, Associate Professor of Statistical Genetics in the Department of Epidemiology at Harvard T.H. Chan School of Public Health. "Our analysis confirmed that cholesterol-lowering drugs would have the expected effect in lowering LDL cholesterol, but this is much weaker compared to the effect of healthy behaviours on VLDL cholesterol which also increases the risk of heart disease." Overall, they found that taking cholesterol-lowering medications and engaging in multiple healthy lifestyles would likely help individuals to achieve the greatest heart-protecting benefits because of the complementary effects of the drugs and healthy behaviours. "Lifestyle interventions and lipid-lowering medications may affect different components of the lipid profile, suggesting they are not redundant strategies but could be combined for improved benefits," concludes co-senior author Jun Lv, Professor at the Department of Epidemiology & Biostatistics at the School of Public Health, Peking University Health Science Center, Beijing, China.   Role of Diet in Colorectal Cancer IncidenceUmbrella Review of Meta-analyses of Prospective Observational Studies University of Utah, February 16 Question  How credible is the evidence behind the association of dietary factors with colorectal cancer (CRC) risk in published meta-analyses of prospective observational studies? Findings  This umbrella review of 45 meta-analyses describing 109 associations found convincing evidence for an association between lower CRC risk and higher intakes of dietary fiber, dietary calcium, and yogurt and lower intakes of alcohol and red meat. Meaning  This study suggests that dietary factors may have a role in the development and prevention of CRC, but more research is needed on specific foods for which the evidence remains suggestive. Abstract Importance  Several meta-analyses have summarized evidence for the association between dietary factors and the incidence of colorectal cancer (CRC). However, to date, there has been little synthesis of the strength, precision, and quality of this evidence in aggregate. Objective  To grade the evidence from published meta-analyses of prospective observational studies that assessed the association of dietary patterns, specific foods, food groups, beverages (including alcohol), macronutrients, and micronutrients with the incidence of CRC. Data Sources  MEDLINE, Embase, and the Cochrane Library were searched from database inception to September 2019. Evidence Review  Only meta-analyses of prospective observational studies with a cohort study design were eligible. Evidence of association was graded according to established criteria as follows: convincing, highly suggestive, suggestive, weak, or not significant. Results  From 9954 publications, 222 full-text articles (2.2%) were evaluated for eligibility, and 45 meta-analyses (20.3%) that described 109 associations between dietary factors and CRC incidence were selected. Overall, 35 of the 109 associations (32.1%) were nominally statistically significant using random-effects meta-analysis models; 17 associations (15.6%) demonstrated large heterogeneity between studies (I2 > 50%), whereas small-study effects were found for 11 associations (10.1%). Excess significance bias was not detected for any association between diet and CRC. The primary analysis identified 5 (4.6%) convincing, 2 (1.8%) highly suggestive, 10 (9.2%) suggestive, and 18 (16.5%) weak associations between diet and CRC, while there was no evidence for 74 (67.9%) associations. There was convincing evidence of an association of intake of red meat (high vs low) and alcohol (≥4 drinks/d vs 0 or occasional drinks) with the incidence of CRC and an inverse association of higher vs lower intakes of dietary fiber, calcium, and yogurt with CRC risk. The evidence for convincing associations remained robust following sensitivity analyses. Conclusions and Relevance  This umbrella review found convincing evidence of an association between lower CRC risk and higher intakes of dietary fiber, dietary calcium, and yogurt and lower intakes of alcohol and red meat. More research is needed on specific foods for which evidence remains suggestive, including other dairy products, whole grains, processed meat, and specific dietary patterns.     Pizza, burgers and the like: A single high-fat meal can damage  metabolism Deutsches Diabetes-Zentrum (Germany), February 16, 2021   The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists at the German Diabetes Center (Deutsches Diabetes-Zentrum, DDZ) and the Helmholtz Center in Munich (HMGU) have found that even the one-off consumption of a greater amount of palm oil reduces the body's sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver. The results of the study provide information on the earliest changes in the metabolism of the liver that in the long term lead to fatty liver disease in overweight persons as well as in those with type 2 diabetes.   In the current issue of the "Journal of Clinical Investigation", DZD researchers working at the German Diabetes Center, in conjunction with the Helmholtz Center in Munich and colleagues from Portugal, published a scientific investigation conducted on healthy, slim men, who were given at random a flavored palm oil drink or a glass of clear water in a control experiment. The palm oil drink contained a similar amount of saturated fat as two cheeseburgers with bacon and a large portion of French fries or two salami pizzas. The scientists showed that this single high-fat meal sufficed to reduce the insulin action, e.g. cause insulin resistance and increase the fat content of the liver. In addition, changes in the energy balance of the liver were proven. The observed metabolic changes were similar to changes observed in persons with type 2diabetes or non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common liver disease in the industrial nations and associated with obesity, the so-called "metabolic syndrome," and is associated with an increased risk in developing type 2 diabetes. Furthermore, NAFLD in advanced stages can result in severe liver damage.   "The surprise was that a single dosage of palm oil has such a rapid and direct impact on the liver of a healthy person and that the amount of fat administered already triggered insulin resistance", explained Prof. Dr. Michael Roden, scientist, Managing Director and Chairman at the DDZ and the German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD). "A special feature of our study is that we monitored the liver metabolism of people with a predominantly non-invasive technology, e.g. by magnetic resonance spectroscopy. This allows us to track the storage of sugar and fat as well as the energy metabolism of the mitochondria (power plants of the cell)." Thanks to the new methods of investigation, the scientists were able to verify that the intake of palm oil affects the metabolic activity of muscles, liver and fatty tissue. The induced insulin resistance leads to an increased new formation of sugar in the liver with a concomitant decreased sugar absorption in the skeletal muscles - a mechanism that makes the glucose level rise in persons afflicted with type 2 diabetes and its pre-stages. In addition, the insulin resistance of the fatty tissue causes an increased release of fats into the blood stream, which in turn continues to foster the insulin resistance. The increased availability of fat leads to an increased workload for the mitochondria, which can in the long term overtax these cellular power plants and contribute to the emergence of a liver disease.   The team of Prof. Roden suspects that healthy people, depending on genetic predisposition, can easily manage this direct impact of fatty food on the metabolism. The long-term consequences for regular eaters of such high-fat meals can be far more problematic, however.    

Als Austauschschülerin kam Kerstin nach Shanghai und traf sogar den späteren Premier Minister Chinas Herrn Zhu. Die prägenden Eindrücke brachten sie wieder nach China. Seit 1999 arbeitet und lebt sie in China. Nach den Stationen Kahla Porzellan und BMW hat sie die Idee von einem German Centre so gut gefunden, so dass sie seit 2007 dort arbeitet. Heute leitet sie die Zweigstelle von German Centre in Qingdao und hilft mit Leidenschaft deutschen kleinen und mittelständischen Kunden für ihren Markterfolg.

A conversation with Henning Boecker, Professor for Clinical Functional Neuro Imaging at the University of Bonn and at the German Center for Neuro Degenerative Disease in Bonn, collector of contemporary art and co-founder of Espace Sauvage in Düsseldorf. Henning speaks about his scientific research, about the effects art and music can have on the brain, how he was initiated into art by his german teacher and Dadaism. He speaks about the older artists that inspired him, why he wanted to relate to his own generation of artists, the individuality of the artistic experience and the reason to open up an art space. He shares how Corona highlights and accelerates certain developments and how collaboration is key in these special times. 34 min., August 2020, Language: English

“One person's data is another person's noise.” - K.C. Cole This week’s Fish Fry podcast is all about noisy neurons, cough signature identification, and how AI can help us stem the tide of COVID-19. First up, we check out new research from the German Center for Neurodegenerative Diseases that may have finally unlocked the mysteries of memory retention in people afflicted with Alzheimer’s disease with a little help from a bunch of mice and some very noisy neurons. Also this week, Chris Rogers (CEO - SensiML) joins us to chat about a new health monitoring solution to help fight the COVID-19 pandemic. We discuss the role of artificial intelligence in this solution and how this new platform may help detect symptoms earlier than before with identification of cough sounds.  

Rob and Jason are joined by Bryce Adelstein Lelbach. They discuss the mdspan proposal that first introduced Bryce to the C++ ISO committee. They also discuss Bryce's role as moderator for the /r/cpp subreddit and talk about the upcoming CppCon 2019 conference. Bryce Adelstein Lelbach Bryce Adelstein Lelbach has spent nearly a decade developing libraries in C++. Bryce is passionate about C++ evolution and is one of the leaders of the C++ community. He is an officer of ISO/IEC JTC1/SC22/WG21, the C++ Standards Committee. Bryce chairs both the C++ Committee's Tooling Study Group (SG15) and Library Evolution Incubator (SG18). He is the program chair for the C++Now and CppCon conferences, and the chief organizer of the Bay Area C++ User Group. On the C++ Committee, he has personally worked on the C++17 parallel algorithms, executors, futures, senders/receivers, multidimensional arrays, and modules. Bryce works at NVIDIA, where he leads the CUDA C++ core libraries team. He is one of the initial developers of the HPX parallel runtime system. He also helped start the LLVM Linux initiative and has occasionally contributed to the Boost C++ libraries. News Resharper 2019.2 released Game Performance Improvements in Visual Studio 2019 16.2 The German Center for Aerospace (DLR) just open sourced CosmoScout VR, which is a universe 'simulator' written in modern C++ Links P0009r6: mdspan: A Non-Owning Multidimensional Array Reference P1684r0: mdarray: An Owning Multidimensional Array Analog of mdspan P1767r0: Packaging C++ Modules /r/cpp/ CppCon 2019 CppCon 2018: Bryce Adelstein Lelbach "The C++ Execution Model" Sponsors Backtrace Announcing Visual Studio Extension - Integrated Crash Reporting in 5 Minutes  

Host Puneet Dhaliwal, PT, DPT, NCS is joined by Dr. Andreas Zwergal, MD, PhD, an associate professor at Department of Neurology and German Center for Vertigo and Balance Disorders at University of Munich, Germany to discuss cerebellar dizziness - assessment and treatment interventions. In this episode they discuss how neurodegenerative and hereditary disorders of the cerebellum often lead to postural vertigo, associated with gait and balance disorders and oculomotor disorders. The importance of correct assessment in the clinic leads to successful intervention. The Vestibular Rehabilitation Special Interest Group is part of the Academy of Neurologic Physical Therapy - www.neuropt.org

Host Puneet Dhaliwal, PT, DPT, NCS is joined by Dr. Andreas Zwergal, MD, PhD, an associate professor at Department of Neurology and German Center for Vertigo and Balance Disorders at University of Munich, Germany to discuss cerebellar dizziness - assessment and treatment interventions. In this episode they discuss how neurodegenerative and hereditary disorders of the cerebellum often lead to postural vertigo, associated with gait and balance disorders and oculomotor disorders. The importance of correct assessment in the clinic leads to successful intervention. The Vestibular Rehabilitation Special Interest Group is part of the Academy of Neurologic Physical Therapy - www.neuropt.org

Gerrit has been living in New York since ten years and currently holds the position as Program Manager at the New York office of the German Center for Research and Innovation (DWIH). He gave us insights into this year’s program, which includes topics like Artificial Intelligence, Big Data, working innovatively in a digital world as well as innovative topics like Nightlife. More about the German Center for Research and Innovation: https://www.dwih-newyork.org/en/  Connect with Gerrit: https://www.linkedin.com/in/gerrit-roessler/

Five experts from the University of Bristol, the German Center for Neurodegenerative Diseases, and the Hungarian Academy of Sciences answer questions from a webinar where they present methodology and research findings from neurophysiological studies in head-fixed, behaving mice.

Five experts from the University of Bristol, the German Center for Neurodegenerative Diseases, and the Hungarian Academy of Sciences answer questions from a webinar where they present methodology and research findings from neurophysiological studies in head-fixed, behaving mice.

Dr Carolyn Lam:                Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr Greg Hundley:             And I'm Greg Hundley, also associate editor from VCU Health Systems, the Poly Heart Center in Richmond, Virginia. Dr Carolyn Lam:                So arrhythmogenic cardiomyopathy that will make most of us think of right ventricular disease and fatty infiltration of the muscle, but could arrhythmogenic cardiomyopathy really be a bi-ventricular disease? Well you've got to stay tuned to find out more in a fantastic interview coming right up after our little coffee chat. So Greg, what are your picks this week? Dr Greg Hundley:             My first paper is from Chris Lim at NYU in New York. And it's looking at the relationship between Mediterranean diet, air pollution and cardiovascular events.                                                 So, it's unknown whether usual individual dietary patterns can modify the association between long-term air pollution exposure and health outcomes. And so, in this large cohort with detailed diet information at the individual level, they had 548000 individuals across six states and two cities within the U.S. and a follow up period of 17 years. And that occurred between 1995 and 2011. And they evaluated whether a Mediterranean Diet modified the association between long-term exposure to ambient air pollution and then cardiovascular disease and mortality risk. And so, the average exposures to parts per billion and nitric oxide air pollution that the residential census track level were measured, and the investigators found that for the particulate matter there were elevated significant associations with cardiovascular disease. So, a hazard ratio of 1.13, ischemic heart disease similar hazard ratio and cerebrovascular disease with also a similar hazard ratio.                                                 For the nitric oxide, there were also significant associations with cardiovascular disease, as well as ischemic heart disease. And then the analysis indicated that Mediterranean diet modified the relationships. Those with a higher Mediterranean diet score had significantly lower rates of air pollution related mortality. These results therefore indicate Carolyn, that Mediterranean diet reduce cardiovascular disease mortality related to long-term exposure to air pollutants in a large perspective, U.S. cohort. Can you believe increased consumption of foods rich in antioxidant compounds actually may aid in reducing the considerable disease burden associated with ambient air pollution? Dr Carolyn Lam:                Oh wow. That is hugely interesting. Gosh, what do we do about this clinically now?  Dr Greg Hundley:            Remember, first of all, this is an associate study, so we can't infer cause effect. And what we need next are some more independent studies from other cities around the world, prospective cohorts, examinations of clinical outcomes and randomize interventions. And so, I think the results add to a growing body of literature suggesting that dietary patterns may help reduce cardiovascular events in these high air pollution exposure areas. And how does this work? Well, potentially through augmenting antioxidants and reducing oxidative stress. Dr Carolyn Lam:                That's really cool. So from one region, talking about air pollution to another region that often reports about air pollution and that's China. But this study from China is actually the largest registry study to evaluate sex related differences and hospital management and outcomes of patients with acute coronary syndrome in China.                                                 This is from corresponding author Dr Zhao from Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease. With colleagues of the improving care for cardiovascular disease in China, Acute Coronary Syndrome project, which is an ongoing nationwide registry of the American Heart Association and the Chinese Society of Cardiology. So, the authors use data from this project and evaluate at sex differences in the acute management, medical therapies for secondary prevention and in hospital mortality in more than 82000 patients admitted for acute coronary syndrome in 192 hospitals across China from 2014 to 2018. Dr Greg Hundley:             What did they show in this study? Dr Carolyn Lam:                They showed that women hospitalized for acute coronary syndrome in China less frequently received acute treatments and strategies for secondary prevention and had a higher in hospital mortality rate than men. Now the observed sex differences in this in hospital mortality were likely due to older age, worse clinical profiles and fewer evidence base acute treatments provided to women. And that's because the sex differences were no longer observed after adjustment for these clinical characteristics and acute treatments.                                                 What this all means though is specifically targeted quality improvement programs may be warranted to narrow these sex related disparities in patients with acute coronary syndrome in China.  Dr Greg Hundley:            Very interesting. I'm going to take sort of the next paper and it's looking at a different aspect of acute myocardial infarction. And these papers from Yong Wang from the Division of Molecular and Translational Cardiology at Hannover Medical School in Hanover, Germany.                                                 Now as we know, the heart can undergo deleterious changes and left ventricular geometry and function during that vulnerable period before scar formation has stabilized the infarct area. And so inflammatory cell trafficking from hematopoietic organs like the spleen to sites of tissue injury is coordinated by chemokine chemokine receptor networks. Therapeutically modulating these chemokine chemokine receptor interactions may promote infarct healing by limiting excessive inflammation induced tissue damage or by enhancing the recruitment of angiogenic cell populations to the infarct or the wound. Inflammatory cell trafficking after a myocardial infarction is controlled by a CXC motif chemokine ligand 12 or CXCL12 and its receptor CXC motif chemokine receptor 4. CXC receptor 4 antagonists, mobilize inflammatory cells and promote infarct repair. But the cellular mechanisms are unclear.                                                 So, what do these investigators do? In mouse models, the investigators found that inflammatory cell trafficking between a hematopoietic organs and sites of tissue injury is controlled by CXCL12 and its receptor CXC receptor 4. And bolus injectives of a highly selected peptidic macrocycles CXC receptor 4 antagonist, enhanced tissue repair and functional recovery after re-perfused acute myocardial infarction in mice. And interestingly, the therapeutic effects require a dendritic cell priming and we're specifically mediated by t-regulator cells. Intermittent CXC R4 blockade mobilized the t-regulator cells from their splenic reservoir. Leading to their enhanced recruitment to the infarct region. Dr Carolyn Lam:                So bring it home for us, Greg. What does this mean clinically for MI management in humans? Dr Greg Hundley:             Right. Highlighting the translational potential. What we might infer is that CXC receptor 4 blockade reduces infarct volume and improved systolic function in a porcine close chest model of re-perfuse acute myocardial infarction.                                                 And so, the results of both the mouse experiments and this sort of translational model in pigs should stimulate further research into therapeutic potential of CXC R4 blockade after MI and in other acute conditions were excessive, innate or adaptive immune responses cause immunopathology. Dr Carolyn Lam:                Fascinating. So from one preclinical paper to another, but this time focused on heart failure. And focus specifically on titin. Titin is this giant elastic protein that spans the half-sarcomere from the Z-disk to the M band, and it acts like a molecular spring and a mechanosensor that has been linked to striated muscle disease. Now the pathways that govern tight independent cardiac growth and contribute to disease are diverse and have been really difficult to dissect. And so corresponding author Dr Gotthardt, from Max Delbruck Center for Molecular Medicine and the German Center for Cardiovascular Research and his colleagues aimed to study titin deficiency versus titin dysfunction.                                                 And how they did that is they generated and compared striatum muscles specific knockouts with progressive postnatal loss of the complete titin protein. And that's by removing Exxon 2. Or an M-band truncation that eliminates the proper structure and integration, but retains all the other functional domains. So they then evaluated cardiac function, cardiomyocytes mechanics, and the molecular basis of the phenotype. Now, what they found was that progressive depletion of titin led to sarcomere disassembly an atrophy in striated muscle. And in the complete knockout, remaining titin molecules had increased strain resulting in mechanically induce trophic signaling and eventual dilated cardiomyopathy.                                                 On the other hand, the truncated titin helped maintain passive properties and thus reduced mechanically and do signaling. In other words, truncations versus loss of titin, differentially affected cardiac pathology with atrophy versus dilated cardiomyopathy respectively. And together, these findings really contribute to the molecular understanding of why titin mutations differentially affect cardiac growth and have implications importantly for genotype, phenotype relations that support a personalized approach to the diverse titinopathy. Dr Greg Hundley:             Interesting, Carolyn. All this information on titin. So why is it clinically important? Dr Carolyn Lam:                Well, first of all, tightened mutations are the most common genetic basis of heart disease and the findings are clinically relevant, as I said, for understanding the genotype phenotype relations at the Titin mutation. But understanding the integration of Titin based signaling and sarcomere biology could indeed help personalize diagnostics by improved clinical decisions and maybe identify suitable therapeutic targets for these titinopathy. But that of course requires much further work. Well that brings us to the end of our summaries. Let's go to our feature discussion.  Dr Greg Hundley:            Welcome everyone to our second segment of our program. We're discussing an interesting paper today entitled Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy. And we want to welcome our coauthors Elijah Behr and Mary Sheppard from St George's University in London. And also, our own associate editor, Sami Viskin to discuss this paper. Mary, can you tell us a little bit about your study design here, the population and the hypothesis and some of your results? Dr Mary Sheppard:          I am a cardiac pathologist of 20 years and I have a special interest in sudden death. Over this time, I've established a national pathology database, where pathologists throughout the country when they have a sudden death, which is likely cardiac and non-ischemic, they will send the heart or tissue blocks insides to me for my opinion concerning the death. We have as a result developed a large number, over 5200 cases which has now built up to 6000. It's the largest pathological series in the world.                                                 And I was also discovering the pathologists were either under or over diagnosing all types of cardiomyopathy but particularly ergogenic cardiomyopathy. And that is why with Chris Miles, our research fellow, we looked in detail at what I had diagnosed, or the pathologist as ergogenic cardiomyopathy and we actually honed are pathological diagnostic criteria for this very important entity. Establishing that left ventricular is five and ventricular and left and ventricular is the norm almost. That right or left ventricular is unusual by themselves and even in 20%, one in five, the heart can look macroscopically normal. So that histology is essential when you're making this diagnosis. You cannot make the diagnosis pathologically without histologically examining the heart. Dr Greg Hundley:             Very good, Mary. And did you also examine some genetic markers in some of the subsets of the patients? And how did you decide who those individuals would be that received the genetic analysis? Dr Mary Sheppard:          A small subset and I will hand over to Elijah Behr, my colleague concerning that. Dr Elijah Behr:                   The genetic tissue is only available in a minority of cases. We've developed a pipeline now with the referring pathologists who are increasingly they're sending samples of spleen suitable for DNA extraction that allow us then to do a retrospective postmortem genetic testing or molecular autopsy. But unfortunately, in this particular series we only had a small proportion. I think there were roughly about 24 out of the 202 cases, so just over ten percent. And interestingly, while we didn't necessarily mirror the expected yield of genetic testing that is seen in clinical cases, where you may see about 40% carrying pathogenic variance. We certainly picked up some important pathogenic variance, particularly those that are often associated with highly penetrant and more severe disease. In particular TMEM43 and desmoplakin. These findings may reflect the small size of the sample, but it also may reflect where the greatest risk for sudden death from ergogenic cardiomyopathy lies. Dr Greg Hundley:             Elijah, getting back to some of the patients that experienced the sudden death in the study population Mary was referring to, were there characteristics that were associated with the sudden death? For example, those that might be related to gender or activity? Dr Elijah Behr:                   So the majority of the cases were male. The majority has never had prior symptoms. These were unheralded deaths. The majority did not have a family history and I think the majority were addressed, but those that were athletes, we're much more likely to have died during exertion. So as we found with ergogenic cardiomyopathy in general and exertion is a trigger to sudden death. The risk was higher and compared to the athletes in death during exertion was associated with being younger as well. I think exertion and sports clearly play a role in ergogenic cardiomyopathy. It didn't appear to play a role in whether there was left ventricular involvement or not, but certainly a role at more severe presentation.  Dr Greg Hundley:            Maybe both Mary and Elijah answering this. You found histopathological evidence of fibrosis and fatty infiltration. How extensive was that? And do you think that could be identified with a test like maybe magnetic resonance imaging? Dr Mary Sheppard:          Yes. Our diagnostic criteria which is illustrated in the addendum is that it was at least two blocks of tissue. We always look at 10 to 12 to 15 blocks of tissue from both right and left ventricle. And at least two of the blocks had to have fibrosis with fat in 20% of the area examined. We did not include inflammation because inflammation is, an important histological criterion in our experience. We were very precise about that because you need that much at least to make the diagnosis. A little bit of fibrosis or a little bit of fat is not sufficient by itself. Dr Greg Hundley:             When you mention a block, for us clinically, how much myocardium would that be? For example, on an imaging test like an echo or an MRI scan. Dr Mary Sheppard:          One to two centimeters squared. Dr Greg Hundley:             So quite a bit. Dr Elijah Behr:                   You're looking at probably around two to four millimeters of potential depth of fibrosis. And what we've seen clinically in LV involvement of MRI scans is miss two epicardial late enhancement. Now the question is whether our scans are sensitive enough to pick that up? Given the technology available or a sense to the histopathology and I think that's why maybe some of the clinical studies have tended to miss the true proportion of left ventricular involvement. Because of the relative subtlety of the fibrosis compared to the technological ability to discriminate it. I mean certainly when you look at our cases that were diagnosed previously with cardiomyopathy, either they were arrhythmogenic or dilated, many did have imaging findings if MRI was performed, that would indicate or suggest some left ventricular involvement. But as you know, the task force criteria for arrhythmogenic cardiomyopathy having very much right ventricular focus. An LV imaging findings and LV ECG findings are just not part of those at the moment. Dr Greg Hundley:             Was there a particular location within the heart where there was a predilection toward the findings of fibrosis and fat? Dr Mary Sheppard:          In the posterior basal wall particularly, transmural involves going from the epicardium to the sub endocardium and also the interior walls of the left ventricular were the predilection areas. Dr Elijah Behr:                   I think that's what we see on our MRI scans as well. When you look at these patients, that posterior basal area, is the one that tends to light up the most. Dr Mary Sheppard:          It is believed that increased stress in that area gives more damage because of the stretching away from the septum. Dr Greg Hundley:             Very interesting. So Elijah, you had mentioned task force criteria. I want to shift to Sami now and ask, Sami, can you help us put this in perspective relative to the existing task force criteria and then the findings in this study? And how that could lead to subsequent changes down the road?  Dr Sami Viskin:                 Okay, so it is difficult to place this in the context of the task force because mentioned by Elijah, the taskforce are focused on a disease that is believed to be in the right ventricle. And the study shows that many of the sudden death cases will involve the left ventricle. One of the most important messages of this paper is importance of her forensic examination. And importance of making it for anything examination in the center of expertise. We know of patients that will travel a thousand miles to undergo surgery or an ablation procedure, but families do not think that way when there is casualty or family dies. You may take a postmortem as a given, but in many countries, including my own, most cases of sudden death would not be followed by a post mortem and will not go into center of expertise. And you cannot overemphasize the importance of doing that because then you have to know what you are looking for in the remaining relatives is extremely important. Dr Greg Hundley:             Very good. How about from the perspective as an electrophysiologist? Does this impact in any way how you might evaluate a younger person with syncope? Dr Sami Viskin:                  Well, it is difficult to conclude from this paper about how to evaluate patients with syncope because most of the cases in this series don't have symptoms at all. But this paper calls to very interesting investigations by Mario del Mar and others in New York. Looking about the electrophysiology consequences of a disease like right ventricle are like a bit mechanical in [inaudible 00:21:58] The tissues becomes editing the disease, the electrical properties how the patients in brugada can cause malfunction of this sodium channel and create a disease that is more like brugada and dysplasia at the beginning. So, the entire correlation between a morphologic disease and the metrical disease and we used to think they are two different things. And now we see that we can actually put them together and you can go through stages where one disease is before an electrical disease and only at later stages it becomes a morphological evident disease.  Dr Greg Hundley:            A fantastic discussion on pathologic findings. Sami making the point that certainly in cases for young individuals having a postmortem examination performed at centers that have expertise such as what Mary's described, can be very important. And then Elijah, helping us to understand with arrhythmogenic cardiomyopathy, number one, findings are not, we shouldn't just be thinking about the right ventricle in isolation, but also the left ventricle. Fibro fatty infiltration, particularly in the posterior basal wall could be an important thing to look for, for those that are performing the magnetic resonance imaging exams. And then lastly, many of the patients in the study like this, the first presentation was of sudden death. And we need to be cognizant that this condition could be prevalent in the population and not necessarily appreciated by some of our current task force guidelines and examinations. So, what an outstanding discussion. And I think for today, we want to thank our authors and our associate editor and wish everyone a great week.                                                 On behalf of Carolyn and myself, we look forward to seeing you next week. Thank you very much. Dr Carolyn Lam:                This program is copyright American Heart Association 2019.  

Cardiovascular factors are associated with risk of stroke - and those factors can be mediated by lifestyle and by genetic make up. New research published by The BMJ sets out to explore how these risks combine, and we're joined on the podcast by two of the authors - Loes Rutten-Jacobs, senior postdoctoral researcher at the German Center for Neurodegenerative diseases, and Susanna Larsson, associate professor at the Karolinska Institutet. Read the full open access research: https://www.bmj.com/content/363/bmj.k4168

1) Age of first exposure to football and the effect of later-life cognitive impairment on former NFL players and 2) Topic of the month: Stroke in systemic disease. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Howard Goodkin interviews Dr. Robert Stern about his paper on the age of first exposure to football and the effect of later-life cognitive impairment on former NFL players. Dr. James Addington is reading our e-Pearl of the week about REM behavior disorder. In the next part of the podcast Dr. Michelle Johansen interviews Dr. Kevin Barrett about the topic of stroke in the setting of Endocrine disorders. The participants had nothing to disclose except Drs. Goodkin, Stern, Addington, Johansen and Barrett.Dr. Goodkin serves on the scientific advisory board for Tuberous Sclerosis Alliance and CURE Infantile Spasms; serves as an editorial board member of Neurology, Surgical Neurology International and Epilepsia; receive a royalty from UpToDate for co-authorship of an entry entitled The "choking game" and other strangulation activities in children and adolescents; will be receiving royalties for editing Epilepsy as part of the Neurology in Practice series and receives research support from the NIH.Dr. Stern serves as an Associate Editor of Journal of Neuropsychiatry and Clinical Neurosciences; serves as an editorial board member of Archives of Clinical Neuropsychology; serves as a Review Editor of Frontiers in Neurotrauma and Frontiers in Sports Neurology; serves as Series Editor of Alzheimer's Research and Therapy; serves on the Mackey-White Traumatic Brain Injury Committee of the National Football League Players Association; serves on the medical advisory board of Sports Legacy Institute, the National Graves' Disease Foundation and Amarantus Biosciences (paid advisor); serves on the Medical and Scientific Advisory Committee of the MA/NH Chapter of the Alzheimer's Association; is a consultant for Janssen Research & Development and Athena Diagnostics; receives publishing royalties from Psychological Assessment Resources, Inc. for the Visual Analog Mood Scales, the Boston Qualitative Scoring System for the Rey-Osterreith Complex Figure, and the Neuropsychological Assessment Battery; receives research support from Eisai Inc., Eli Lilly and Company, Amarantus Biosciences, Aethlon Medical, Avid Radiopharmaceuticals, the Department of Defense and the NIH; received honorariums from, Braintree Neurorehabilitation Conference, National Academy of Neuropsychology, Harvard Medical School, The German Center for Research and Innovation and Ludwig-Maximilians-Universitat Munchen, Medical University of South Carolina, Spaulding Rehabilitation Hospital and 8th Annual National Summit on Sports Concussion.Dr. Addington serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Johansen serves as a scientific advisory member of Stroke and as a contributor to Blogging Stroke.Dr. Kevin Barrett serves as an Associate Editor of Neurohospitalist; serves as an editorial board member of Neurology; and receives research support from the NIH.

Stephan Hartmann (MCMP/LMU) gives an evening lecture on "Mathematical Philosophy, Science and Public Policy", hosted by the German Center for Research and Innovation (GCRI) on occasion of the MCMP workshop "Bridges 2014" in the German House, New York City (2 and 3 September, 2014). Abstract: What is the proper method of philosophy? To what extent does the philosophical method differ from the scientific method? Many philosophers believe that philosophy is an armchair activity and that the exact methods of the natural and social sciences cannot guide philosophical research. Scientific Philosophy, on the contrary, maintains that philosophical theses and arguments should be just as clear and precise as scientific ones: philosophers ought to build theories and models as much as scientists do; and the application of mathematical methods as well as input from empirical studies are often necessary in order to gain new insights into old philosophical questions and to progress to new and deeper ones. This talk spells out Scientific Philosophy by focusing on central themes from the philosophy of science. It focuses on understanding aspects of scientific rationality and presents descriptively adequate and normatively interesting models of intertheoretic relations, scientific reasoning, and decision-making in a scientific community. These topics have a philosophical as well as a scientific dimension, and addressing them requires a combination of methods from both areas.

Philipp Kahle, Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Faculty of Medicine, University of Tübingen - GERMANY speaks on "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 ubiquitinylation - RNA Metabolism: Changing Paradigms in Neurodegeneration”. This seminar has been recorded at Area Science Park Trieste by ICGEB Trieste

Bettina Schmid, German Center for Neurodegenerative Diseases(DZNE), Munich - GERMANY speaks on "In vivo function of TDP-43 in zebrafish - RNA Metabolism: Changing Paradigms in Neurodegeneration".This seminar has been recorded at Area Science Park Trieste by ICGEB Trieste

Thomas Gaeghtens, current director of the Getty Research Institute and recent director of the German Center for the History of Art, Paris, reflects on Berlin's encyclopedic National Museums and their history.yclopedic National Museums and their history. This podcast is brought to you by the Ancient Art Podcast. Explore more at ancientartpodcast.org.