Podcasts about Angiogenesis

Ever feel like your workouts just aren't delivering the same results anymore? You're training hard, lifting heavy, and doing everything “right,” but somehow, progress stalls. Strength fades. Recovery slows. And your joints? Yeah, they're not loving it either.Here's the truth: it's not your age—it's your approach.That's why I brought in Nick Nilsson, aka The Mad Scientist of Muscle. This guy has spent decades reinventing the way we build muscle, train smart, and stay strong—especially as we get older. His Return to Prime system isn't about grinding yourself into the ground. It's about training smarter, not harder, by optimizing the four key systems that fuel muscle growth.I put his method to the test, and let me tell you—it humbled me in the best way possible. This workout forced my body to adapt in ways I didn't even think were possible.Timestamps:09:29 Nick's origin story and fitness background21:00 How Nick created his "best exercises you've never done" brand28:48 The inspiration behind the Return to Prime program33:36 Phase 1: Angiogenesis training for rebuilding circulation46:08 Phase 2: Connective tissue training and hydraulic circulation1:00:14 Phase 3: Hyperplasia training for increasing muscle fiber numbers1:10:30 Phase 4: Nervous system efficiency and activation training1:24:42 Nutrition recommendations for each training phase1:32:10 Final thoughts: Have fun whith training!Mentioned Resources:Mad Scientist of Muscle website: https://www.madscientistofmuscle.com/ The Best Exercises You've Never Heard Of: https://www.fitstep.com/2/the-best-exercises-index/index.htm Return to Prime: https://www.fitstep.com/2/return-to-prime/index-story.htm

In this episode of The Visible Voices Podcast, Dr. William Li, a physician researcher and CEO founder of The Angiogenesis Foundation, joins to talk about starving cancer with food and more generally about food as medicine. We discuss the concept of angiogenesis, the impact of diet on cancer, and debunk common myths surrounding coffee, soy, and eggs. Dr. Li emphasizes the importance of nutrition education in medical training and shares recent discoveries about the health benefits of oats.  Will reflects on the challenges of communicating complex medical concepts to the public and the significance of empowering patients with knowledge about their health.  Some conversation learning points:Food is a powerful tool in preventing disease. Angiogenesis is a key factor in cancer development. Soy does not cause breast cancer; it may actually help. Nutrition education is lacking in medical training. High-quality eggs can be beneficial for health. Oats contain bioactives that promote gut health. Coffee has anti-inflammatory and anti-cancer properties. Dietary fiber is essential for cancer patients. Empowering patients can lead to better health outcomes. Check out Will's content: 2023 Eat to Beat Your Diet (book) 2021 Eat to Beat Disease (book) 2010 Can We Eat To Starve Cancer? (TED Talk) If you enjoy the show, please leave a ⭐⭐⭐⭐⭐ rating or review on Apple or YouTube , subscribe via the Website and forward to a friend.

Guest Kristy Red-Horse is a biologist who specializes in coronary artery development and disease. She says the latest advances in treatment of blockages could do away with invasive bypass surgeries in favor of growing new arteries using molecules like CXCL12, known to promote artery regrowth in mice. Red-Horse explains how leaps forward in medical imaging, expanding atlases of gene expressions, and new drug delivery mechanisms could someday lead to trials in humans. But, before that day can arrive, much work remains, as Red-Horse tells host Russ Altman in this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Kristy Red-HorseKristy's Lab: Red-Horse LabConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Kristy Red-Horse, a professor of biology at Stanford University.(00:03:46) Replacing Open-Heart SurgeryWhy bypass surgery is invasive, risky, and requires long recovery.(00:05:09) Challenges in Artery GrowthThe difficulty of targeting artery growth with medical interventions.(00:07:32) The Role of Collateral ArteriesDefinition and function of collateral arteries as natural bypass.(00:09:37) Triggers for Natural Bypass FormationGenetic factors that may influence the growth of these bypass arteries.(00:10:49) Unique Properties of Coronary ArteriesChallenges of ensuring artificial growth replicates natural artery function.(00:13:04) The Discovery of CXCL12A key molecule that stimulates collateral artery formation.(00:16:16) Precise Artery Growth ControlThe results of targeted CXCL12 injections into mice hearts.(00:17:32) CXCL12's Overlooked RoleThe molecule's role in the immune system and stem cells.(00:20:27) Guinea Pigs and Heart Attack ResistanceHow guinea pigs naturally develop collaterals.(00:23:19) Preventing Heart DiseaseUsing artery growth treatments to target early-stage coronary disease.(00:25:25) Breakthroughs in Imaging TechnologyNew technology that enables identification of collateral growth pathways.(00:27:07) How Collateral Arteries FormThe two mechanisms in which new arteries form.(00:28:48) The Future of Medical Artery GrowthThe possibility of eliminating bypass surgery with targeted artery growth. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

References:Weight loss on GLP-1 receptor agonistsMoiz A, Levett JY, Filion KB, et al. Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Cardiol 2024, 222:121-130.Highlights: On average, weight loss on semaglutide (Ozempic) is approximately 15% of body weight.Gastrointestinal adverse effects of GLP-1 receptor agonistsSodhi M, Rezaeianzadeh R, Kezouh A, Etminan M. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss. JAMA 2023.Nutrient Density and Satiety:Drewnowski, A.. Concept of a nutritious food: toward a nutrient density score. The American Journal of Clinical Nutrition 2005. Nutrient-dense foods like greens and beans have been shown to promote satiety, support weight loss, and provide essential micronutrients.Highlights: Nutrient-dense foods can naturally regulate appetite and reduce caloric intake without sacrificing nutrition.Anti-Angiogenic Effects of Vegetables and Mushrooms:Li WW, Li VW, Hutnik M, Chiou AS. Tumor angiogenesis as a target for dietary cancer prevention. J Oncol 2012, 2012:879623. Certain foods, like cruciferous vegetables and green tea, have anti-angiogenic properties that not only combat tumor growth.Corvera S, Solivan-Rivera J, Yang Loureiro Z. Angiogenesis in adipose tissue and obesity. Angiogenesis 2022, 25:439-453.Cao QZ, Lin ZB. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta pharmacologica Sinica 2004, 25:833-838.Highlights: Anti-angiogenic foods limit blood vessel growth in fat cells, aiding in long-term weight management.Role of Fiber in Appetite Suppression:Slavin, JL. Dietary fiber and body weight. Nutrition. 2005. High-fiber foods, such as beans and greens, slow digestion, lower postprandial glucose levels, and enhance satiety, contributing to sustainable weight loss.McRorie JW, Jr., McKeown NM. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. J Acad Nutr Diet 2017, 117:251-264.Highlights: Fiber promotes healthy gut microbiota, which indirectly regulates appetite, and viscous fiber directly regulates appetite by slowing breakdown of macronutrients.Green Tea and Weight Regulation:Neyestani TR, Nikooyeh B. A comprehensive overview on the effects of green tea on anthropometric measures, blood pressure, glycemic and lipidemic status: An umbrella review and meta meta-analysis study. Nutr Metab Cardiovasc Dis 2022, 32:2026-2040. Green tea's catechins and mild caffeine content have been shown to modestly increase fat oxidation and support metabolic health.Highlights: Green tea is a natural complement to weight-loss strategies.Nut Consumption and Caloric Absorption:Tindall AM, Petersen KS, Lamendella R, et al. Tree Nut Consumption and Adipose Tissue Mass: Mechanisms of Action. Curr Dev Nutr 2018, 2:nzy069.Highlights: Whole nuts, not oils, reduce caloric intake without compromising satisfaction.

Connect with Dr. Craig Robbins: limblengthening.org Have questions about peptides and recovery? Drop them in the comments below, and we'll try to answer them during the livestream! #Peptides #BPC157 #TB500 #SurgeryRecovery #LimbLengthening #PostSurgeryHealing #Cyborg4Life #DrCraigRobbins #DrScottWillis ________ Audio Podcast: will be available within 48hrs when stream ends Timestamps: 0:00 - Intro Music0:25 - Welcome to Episode 1420:37 - Introducing Dr. Craig Robbins and Dr. Scott Willis1:05 - Dr. Willis' Expertise and Background1:35 - Overview of Peptides for Recovery2:06 - Dr. Robbins' Initial Thoughts on Peptides2:53 - Peptides vs. Natural Healing3:23 - Masterclass on Peptides with Dr. Scott Willis3:39 - What Are Peptides?5:01 - Peptides and Post-Surgical Recovery6:06 - Popular Recovery Peptides: BPC-157 and TB-5008:14 - Angiogenesis and Healing Properties of BPC-1579:31 - Effectiveness of Peptide Injections vs. Oral Peptides10:18 - FDA Regulations on Peptides12:26 - The Wolverine Stack: BPC-157 and TB-50016:01 - Anti-Inflammatory Properties of Peptides19:05 - Peptides vs. Testosterone and Growth Hormone21:18 - Growth Hormone Releasing Peptides (Secretagogues)24:19 - The Role of Testosterone in Healing27:12 - Optimizing Recovery for Older Patients30:01 - Challenges of Recovery After Surgery32:10 - Peptides for Bone Healing in Consolidation Phase35:05 - Risks of Self-Administering Peptides38:09 - Protocols for Optimized Recovery41:04 - Importance of Protein and Nutrition44:06 - Synergy Between Peptides and Nutrition46:45 - Peptides for Sleep: Delta Sleep Inducing Peptide (DSIP)48:53 - Anecdotal Evidence for Peptide Effectiveness50:49 - Combining Therapies for Recovery55:05 - Exploring Additional Peptides: GHK-Cu and DSIP59:01 - Future of Peptides in Medicine1:02:26 - Practical Challenges and FDA Lists1:04:43 - Lifestyle Medicine and Chronic Health Solutions1:07:29 - Dr. Robbins' Insights on Limb Lengthening Recovery1:12:04 - Gym Equipment Enthusiasm with Dr. Willis1:17:19 - Victor's Bodybuilding Journey1:25:02 - Closing Remarks ________

In this episode of the Thrive State Podcast, Dr. Kien Vuu sits down with Dr. William Li, a world-renowned medical doctor and researcher, to explore the groundbreaking science of angiogenesis—the process by which new blood vessels are formed in the body. They dive into how angiogenesis affects everything from cancer prevention to healing and longevity. Dr. Li shares powerful insights on how the food we eat can influence our health at the cellular level and offers practical advice on how to optimize your diet for disease prevention and overall well-being. Don't miss out on this fascinating conversation on how the right foods can boost your health and healing power. Tune in to learn more! Episode Highlights: What is Angiogenesis? The Link Between Angiogenesis and Disease How Foods Influence Angiogenesis Foods that Fight Cancer and Other Diseases Practical Tips for Everyday Wellness The Future of Medicine and Food

BUFFALO, NY- December 4, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 22, 2024, entitled, “The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells.” Researchers Murad K. Nazzal, Hanisha L. Battina, Nikhil P. Tewari, Sarah L. Mostardo, Rohit U. Nagaraj, Donghui Zhou, Olatundun D. Awosanya, Saveda K. Majety, Sue Samson, Rachel J. Blosser, Ushashi C. Dadwal, Patrick L. Mulcrone, and Melissa A. Kacenaat from Indiana University School of Medicine and Richard L. Roudebush Veterans' Administration Medical Center, have uncovered how certain bone marrow cells, called megakaryocytes (MKs), promote the growth of new blood vessels (angiogenesis) to aid in bone healing. Their findings help explain why healing slows with age and offer insights into potential treatments to accelerate fracture recovery in older adults. Broken bones are common in older adults, and slower healing can lead to complications and longer hospital stays. Accelerating the healing process could significantly improve the quality of life for millions. In this study, researchers investigated the effects of substances secreted by MKs, collected from young and older male and female mice. These substances, known as conditioned media (CM), were tested for their ability to stimulate the growth and function of endothelial cells (EC), which form the building blocks of blood vessels. Blood vessels play a critical role in healing by delivering oxygen and nutrients to damaged areas, making angiogenesis a vital part of the recovery process. The results showed that CM from younger MKs mice was more effective at helping blood vessels grow. Interestingly, MKs from female mice performed better than those from males, regardless of age. For example, substances from female MKs mice boosted blood vessel growth by over 115% and significantly improved the movement of cells needed for healing. The researchers also studied changes in genes related to blood vessel growth, and found that aging affects how these genes work. These changes may explain why older people heal more slowly after breaking a bone. “An understanding of which factors regulate which mechanisms of EC functionality may allow for isolation of one or a few factors that influence EC migration changes with aging, resulting in the development of targeted therapy to improve EC migration, subsequent angiogenesis, and fracture healing.” In conclusion, this research paves the way for developing new therapies to help older individuals recover from fractures more quickly, reducing pain and improving mobility. One potential approach could involve creating treatments that replicate the effects of MKs from younger individuals or isolating the specific substances that promote blood vessel growth. This represents an important step toward addressing the growing challenge of delayed healing in an aging population. DOI - https://doi.org/10.18632/aging.206077 Corresponding authors - Patrick L. Mulcrone - pamulcro@iu.edu, and Melissa A. Kacena - mkacena@iupui.edu About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

In this episode, hosts Reed Davis and Dr. Gonshor delve into the surprising research on how antioxidants, commonly seen as beneficial, can stimulate BAC1-dependent tumor angiogenesis, potentially aiding the growth and spread of cancerous tumors. They explain the mechanism by which vitamin C and other antioxidants contribute to new blood vessel formation in tumors, discuss the implications for cancer patients, and emphasize the need for careful consideration of antioxidant use. The episode also touches on recent findings regarding the incidence of long COVID with different coronavirus variants and underscores the importance of healthy lifestyle choices.  Get Functional Diagnostic Nutrition's best free resources at fdntraining.com/resources.

In this episode of the Life of Flow podcast, hosts dive deep into the cutting-edge world of limb salvage surgery with Dr. Michael Theodoulou, a podiatrist, Assistant Professor of Surgery at Harvard Medical School, and Chief of Foot and Ankle Surgery at Cambridge Health Alliance. Dr. Theodoulou introduces listeners to an innovative approach called distraction angiogenesis, which is helping patients with severe lower extremity conditions that have left them with "no option" for treatment. Dr. Theodoulou on the Impact of Distraction Angiogenesis:"We've seen significant improvements in blood flow and healing in patients with no other options. The angiogenesis response from controlled fractures can be remarkable." Hosts on the Future of Vascular Surgery:"There's a real intellectual curiosity here, and the results are exciting. Techniques like this could change how we approach limb salvage."

The fields of Cell and gene therapy are booming and poised to change the treatment and prevention of disease. These research areas require the transfer of genetic material to cells, and viral vectors are commonly used here. Specifically, adeno-associated virus (AAV) and lentiviral vectors (LVV) are vectors of choice. We're joined for this episode by MinGin Kim and Kimberly Gomez, both scientists at Thermo Fisher. With backgrounds and expertise in the areas of cell and gene therapy, they help explain what all the excitement is about and how AAV and LVV are used. We hear about some of the challenges associated with viral vector work and get to hear about how digital PCR (dPCR) and good assay design are helping overcome many of these challenges to enable research and the biopharmaceutical industry. As you might expect from Absolute Gene-ius, you also get to hear their respective career path journeys and some really interesting lab stories.Visit the Absolute Gene-ius page to learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23, pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination.  This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateína: https://drinkmateina.com/huberman Levels: https://levels.link/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Peptides (00:03:20) Sponsors: Mateina, Levels & Joovv (00:07:44) What is a Peptide? (00:12:06) Peptide Sourcing, Lipopolysaccharide (LPS) (00:14:48) Rejuvenation & Tissue Repair: BPC-157, Angiogenesis (00:21:50) BPC-157 & Tissue Injury; Mode of Delivery (00:27:53) BPC-157: Safety, Doses, Cycling, Tumor Risk (00:35:16) Sponsor: AG1 (00:36:43) Tissue Repair: Thymosin Beta-4, TB-500 (00:40:49) Growth & Metabolism: Growth Hormone, IGF-1, Risks (00:45:25) Secretagogues, Sermorelin, Tesamorelin, CJC-1295 (00:52:21) Sponsor: LMNT (00:53:44) Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing (00:58:69) Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing (01:06:12) Longevity: Thymosin Beta-4, Epitalon (Epithalon) (01:12:09) Vitality: Melanotan, PT-141 (Vyleesi), Risks (01:17:21) Vitality: Kisspeptin (01:21:46) Peptides, Potential Benefits, Side-Effects & Risks (01:24:19) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

Get early access to The Perfect Health Lesson, and the classroom and FREE web class that are discussed in today's lesson. ⁠⁠⁠⁠⁠Click this link now⁠⁠⁠⁠⁠ In today's episode: Raising your CRF score, which reflects your body's ability to utilize oxygen during exercise, triggers several molecular and physiological adaptations that contribute to the formation of new blood vessels (angiogenesis) and the remodeling of existing arteries (arteriogenesis). Here's how these processes occur and contribute to lowering your clinical risk of cardiovascular disease: Increased Oxygen Demand: When you engage in physical activity, your muscles require more oxygen to meet the increased energy demands. This elevated oxygen demand stimulates the release of signaling molecules such as vascular endothelial growth factor (VEGF) and nitric oxide (NO) within the vascular endothelium. Stimulation of Angiogenesis: VEGF is a key factor in promoting the growth of new blood vessels (angiogenesis) from pre-existing ones. This process helps to expand the network of blood vessels, improving oxygen delivery to tissues and organs. Enhanced angiogenesis ensures adequate blood supply to active tissues, reducing the risk of ischemia and promoting tissue repair and regeneration. Promotion of Arteriogenesis: Nitric oxide (NO), produced by endothelial cells in response to increased blood flow and shear stress, plays a crucial role in arteriogenesis. More inside the episode...

Dr. Philip Rosenfeld joins to discuss the Angiogenesis 2024 meeting, with topics covered including imaging breakthroughs for age-related macular degeneration, geographic atrophy treatment benefits and risks, and the importance of molarity in assessing efficacy and safety of intravitreal agents.Relevant Financial Disclosures: Dr. Rosenfeld has consulted for Regeneron and Zeiss. Dr. Sridhar has consulted for Apellis, Genentech, Iveric, and Regeneron.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Episode Highlights With Katrina FoeThe root drivers of cancer and what we all need to know to avoid itLess than 10% of cancers are genetically inheritedThe root cause drivers of cancer and the tests that relate to themWhat the metabolic drivers of cancer arePreventative tests that can indicate early cancer riskHow hormones relate to cancerMicrobiome connections to cancer and what to know to improve itWhat angiogenesis is and why it mattersHow environmental toxins can relate to cancerThe emotional component to any diagnosis Why she got kicked out of the cancer treatment clinic and why she is so grateful for itHer take on coffee enemas Why too much protein isn't ideal with her cancer protocolThe therapeutic ranges for ketosisResources We MentionCancer FreedomInstagram - KatrinaNutritional Pilates: Relieve Joint Pain, Lose Unwanted Weight, and Prevent Chronic Disease to Become Your Most Vibrant Self by Katrina FoeTripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms by Travis ChristoffersonThe Roadmap to Prevent Cancer Recurrence - Free ebook watercheck.comLevels Glucose MonitorKeto monitor

Break out your dictionaries! Michelle dives in to explaining all about phytonutrients and other words Kevin isn't brave enough to try to pronounce. But don't worry - they really aren't that scary... in fact, they are the nutritional superheroes! They can help your body fight lots of nasty diseases and conditions - and they're so easy to find!

The creation of new blood vessels can fuel tumors and the accumulation of body fat

In this episode of The Luke Coutinho Show, I am privileged to bring you an eye-opening discussion with the internationally acclaimed, Dr. William Li, a physician, Harvard-scientist, and NYT bestselling author of the groundbreaking books -  ‘Eat To Beat Your Diet' and ‘Eat To Beat Disease.' Delve into the science of food as medicine as we discuss: The 'why' behind nutrition and meaningful lifestyle changesThe five health defense systems: Angiogenesis, DNA, microbiome, immunity, and stem cellsThe role of food in activating the body's defense systems and preventing diseasesModern molecular science in nutritionThe link between cancer, DNA, inflammation, and angiogenesisThe 'Goldilocks zone' where our body precisely manages food intakeImpact of genetically modified organisms (GMOs) on health and the gutAnd much more…

If you're looking to improve your circulation / blood flow and athletic performance or simply combat increased vascular permeability (which can create edema and, therefore, hypoxia) due to the damaging effects of hyperglycemia, inflammation, toxins, etc..., then this episode is a MUST-listen! We're delving into the intricacies of the vesugen bioregulator peptide – so stay tuned for some pretty intriguing research! Topics: 1. Introduction to the Episode - Previous background interest in vesugen: Lyme and Mold / CIRS issues - Introduction to bioregulator peptide vesugen - Effects on blood vessels, circulation, hypoxia, and athletic performance 2. Quick Overview of CIRS and the Circulatory System - Damage to the endothelial blood vessel wall due to high MMP-9 levels - Hemolysins released by MARCoNS - Narrowed capillaries and induced hypoxia - Interest in vesugen 3. Blood Cell Formation - Hematopoiesis - Process and origin in the bone marrow - Characteristics of multipotent hematopoietic stem cells (HSCs) - Regulation of HSC self-renewal vs. differentiation - Myeloid and Lymphoid Progenitors - Differentiated blood cells from each progenitor type - Pathway: Myeloid progenitor to erythrocyte - Role of Erythropoietin (EPO) 4. Maturation Process of Erythrocytes - Ejection of nucleus and organelles - Hemoglobin acquisition - Biconcave shape for optimal gas exchange - Transition to the bloodstream via sinusoids 5. Vascular Wall Anatomy and Dysfunction - Overview of vascular wall layers: Tunica intima, tunica media, and tunica externa - Detailed understanding of endothelial cell functions - Barrier function and vascular permeability - Vascular tone and blood flow regulation - Inflammation and the role in immune response - Angiogenesis and its significance 6. Bioregulator Peptide Vesugen - Definition and unique characteristics - Composition: Lysine, Glutamine, and Asparagine - Mechanism of action: Promotion of endothelial cell proliferation 7. Benefits and Potential of Vesugen - Restoration of endothelial function - Role in injury and endothelial dysfunction scenarios: edema, hypoxia, etc... - Protective effect on the blood-brain barrier - Impact on nitric oxide production and athletic performance, hair growth, skin health Thanks so much for tuning in! Pre-Order Chloe's Book "⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Drs Michelle Kittleson and Bonnie Ky discuss the field of cardio-oncology and how cancer treatment-related cardiotoxicity can be prevented, detected, and treated to improve the quality of cancer survivorship. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/982164). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Heart Failure https://emedicine.medscape.com/article/163062-overview Cardio-oncology: A New and Developing Sector of Research and Therapy in the Field of Cardiology https://pubmed.ncbi.nlm.nih.gov/30073443/ Cardiovascular Effects of Neuregulin-1/ErbB Signaling: Role in Vascular Signaling and Angiogenesis https://pubmed.ncbi.nlm.nih.gov/24283954/ Heart Failure in Patients With Cancer Treated With Anthracyclines-Revisiting the Foundation of Cardio-oncology https://pubmed.ncbi.nlm.nih.gov/36735260/ 2022 ESC Guidelines on Cardio-oncology Developed in Collaboration With the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS) https://pubmed.ncbi.nlm.nih.gov/36017568/

Expanding body fat releases blood supply-generating factors that may end up hooking up tumors, too.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.16.549192v1?rss=1 Authors: Torres-Espin, A., Rabadaugh, H., Fitzsimons, S., Chou, A., Harvey, D., Lindberg, C., Goldberger, L., Casaletto, K. B., Staffaroni, A., Maillard, P., Miller, B. L., Hinman, J. D., DeCarli, C., Ferguson, A. R., Kramer, J., Elahi, F. M. Abstract: Aberrant angiogenesis could contribute to cognitive impairment, representing a therapeutic target for preventing dementia. However, most angiogenesis studies focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in two deeply phenotyped human cohorts (n=435, age 74+9) with longitudinal cognitive assessments, biospecimens, structural brain imaging, and clinical data. Machine learning and traditional statistics revealed sex dimorphic associations of plasma angiogenic growth factors with brain aging outcomes. Specifically, angiogenesis is associated with higher executive function and less brain atrophy in younger women (not men), a directionality of association that reverses around age 75. Higher levels of basic fibroblast growth factor, known for pleiotropic effects on multiple cell types, predicted favorable cognitive trajectories. This work demonstrates the relevance of angiogenesis to brain aging with important therapeutic implications for vascular cognitive impairment and dementia. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.10.548410v1?rss=1 Authors: Biswas, S., Shahriar, S., Bachay, G., Arvanitis, P., Brunken, W. J., Agalliu, D. Abstract: Interactions among neuronal, glial and vascular components are crucial for retinal angiogenesis and blood-retinal barrier (BRB) maturation. Although synaptic dysfunctions precede vascular abnormalities in many retinal pathologies, how neuronal activity, specifically glutamatergic activity, regulates retinal angiogenesis and BRB maturation remains unclear. Using in vivo genetic studies in mice, single cell RNA sequencing and functional validation, we show that deep plexus angiogenesis and paracellular BRB maturation are delayed in Vglut1-/- retinas, where neurons fail to release glutamate. In contrast, deep plexus angiogenesis and paracellular BRB maturation are accelerated in Gnat1-/- retinas, where constitutively depolarized rods release excessive glutamate. Norrin mRNA expression and endothelial Norrin/{beta}-catenin activity are downregulated in Vglut1-/- retinas, and upregulated in Gnat1-/- retinas. Pharmacological activation of endothelial Norrin/{beta}-catenin signaling in Vglut1-/- retinas rescued defects in deep plexus angiogenesis and paracellular BRB integrity. Our findings demonstrate that glutamatergic neuronal activity regulates retinal angiogenesis and BRB maturation by modulating Norrin/{beta}-catenin signaling. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Get ready to embark on an electrifying journey that will revolutionize your relationship with food and health!In this mind-blowing episode, you'll learn how to “Eat your way to better health." And who better to guide us than the extraordinary DR. WILLIAM LI—the world's foremost authority on the incredible power of food.Oh and yea , we're discussing Ozempic and similar injections AND Groundbreaking work on Cancer cells! This is something you have NEVER heard before!Dr. Li is about to unveil the secrets that will rock your understanding of nutrition and well-being. With over 40 FDA-approved breakthroughs under his belt, revolutionizing cancer treatment, cardiovascular health, wound healing, vision restoration, and NYT Bestselling book, his expertise is unparalleled.Brace yourself for this groundbreaking exploration of FOOD AS MEDICINE packed with game-changing insights that will directly impact your health—no matter where you are on your health journey!Prepare to take notes as we uncover:How to EAT your way to healthThe profound effects of EXTREME and FAD DIETING, both the good and the badThe dangers of relying on PRESCRIPTION DRUGS for weight lossA comprehensive exploration of ANGIOGENESIS and its implications for overall healthUnderstanding the critical role of HEALTHY BLOOD VESSELS in maintaining well-beingUncovering how food influences INFLAMMATION within the bodyAn eye-opening discussion on the daily formation of CANCER CELLS in our bodiesThe significance of embracing WHOLE FOODS to optimize healthThe impact of WHITE FAT AND BROWN FAT on our bodiesAND Dr. Li shares his cutting-edge research that will forever reshape your understanding of your body's metabolic processes and the connection between SLEEP, INTERMITTENT FASTING, and your body's ability to unleash its fat-burning superpowers.Dr. Li's groundbreaking insights on HARNESSING THE POWER OF EVERYDAY FOODS will activate your body's hidden potential, unleashing a new era of vitality and long-term health and revolutionize your well-being!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.19.537575v1?rss=1 Authors: Zink, J., Froemel, T., Boon, R. A., Fleming, I., Benz, P. M. Abstract: Endothelial tip cells are essential for VEGF-induced angiogenesis, but underlying mechanisms are elusive. Endothelial-specific deletion of EVL, a member of the mammalian Ena/VASP protein family, reduced the expression of the tip cell marker protein endothelial cell specific molecule-1 (Esm1) and compromised the radial sprouting of the vascular plexus in the postnatal mouse retina. The latter effects could at least partly be attributed to reduced VEGF receptor 2 (VEGFR2) internalization and signaling but the underlying mechanisms(s) are not fully understood. In the present study, we revealed that the expression of the long non-coding RNA H19 was significantly reduced in endothelial cells from postnatal EVL-/- mice and in siRNA-transfected human endothelial cells under hypoxic conditions. H19 was recently shown to promote VEGF expression and bioavailability via Esm1 and hypoxia inducible factor 1 (HIF-1). Similar to EVL-/- mice, the radial outgrowth of the vascular plexus was significantly delayed in the postnatal retina of H19-/- mice. In summary, our data suggests that loss of EVL not only impairs VEGFR2 internalization and downstream signaling, but also impairs VEGF expression and bioavailability in the hypoxic retina via downregulation of lncRNA H19. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.08.527688v1?rss=1 Authors: Robillard, S., Tran, K., Brazeau, T., Boisvert, E., Lizotte, F., Auger-Messier, M., Boudreault, P.-L., Marsault, E., Geraldes, P. Abstract: Objective: Peripheral artery disease (PAD) is a major risk factor for lower-extremity amputation in diabetic patients caused by an insufficient angiogenic response. Unfortunately, therapeutic angiogenesis using growth factors, such as the vascular endothelial growth factor (VEGF), are ineffective in diabetic conditions due to diabetes-induced growth factor resistance. The apelinergic system (APJ receptor/apelin) is highly upregulated under hypoxic condition and acts as an activator of angiogenesis. Apelin treatment has been shown to improve revascularization in nondiabetic models of ischemia, however, its role on angiogenesis in diabetic conditions remains poorly investigated. Thus, this study explored the impact of Pyr-apelin-13 in endothelial cell function and diabetic mouse model of hindlimb ischemia. Approach and Results: Nondiabetic and diabetic mice underwent femoral artery ligation to induce lower limb ischemia. A group of diabetic mice was implanted subcutaneously with osmotic pumps delivering Pyr-apelin-13 for 28 days. Blood flow reperfusion was measured for 4 weeks post-surgery and exercise willingness was assessed in individual cages with voluntary wheels. In vitro, BAECs were exposed to normal (NG) or high glucose (HG) levels and hypoxia. Cell migration, proliferation and tube formation assays were performed following either VEGF or Pyr-apelin-13 stimulation. Following limb ischemia, blood flow reperfusion, functional recovery of the limb and vascular density were improved in diabetic mice receiving Pyr-apelin-13 compared to untreated diabetic mice. In cultured BAECs, exposure to HG concentrations and hypoxia reduced VEGF proangiogenic actions, whereas apelin proangiogenic effects remained unaltered. Pyr-apelin-13 induced its proangiogenic actions through Akt/AMPK/eNOS and RhoA/ROCK signaling pathways under both NG or HG concentrations and hypoxia exposure. Conclusion: Pyr-apelin-13 promoted endothelial cell function and angiogenesis in the ischemic limb despite diabetes and HG level exposure. Therefore, our results identified the apelinergic system as a potential therapeutic target for angiogenic therapy in diabetic patients with PAD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527726v1?rss=1 Authors: Inoue, O., Goten, C., Hashimuko, D., Yamaguchi, K., Takeda, Y., Nomura, A., Ootsuji, H., Takashima, S., Iino, K., Takemura, H., Halurkar, M., Lim, H.-W., Hwa, V., Sanchez-Gurmaches, J., Usui, S., Takamura, M. Abstract: Therapeutic angiogenesis using mesenchymal stem/stromal cell grafts have shown modest and controversial effects in preventing amputation for patients with critical limb ischemia. Through single-cell transcriptomic analysis of human tissues, we identified CD271+ progenitors specifically from subcutaneous adipose tissue (AT) as having the most prominent pro-angiogenic gene profile distinct from other stem cell populations. AT-CD271+ progenitors demonstrated robust in vivo angiogenic capacity, over conventional adipose stromal cell grafts, characterized by long-term engraftment, augmented tissue regeneration, and significant recovery of blood flow in a xenograft model of limb ischemia. Mechanistically, the angiogenic capacity of CD271+ progenitors is dependent on functional CD271 and mTOR signaling. Notably, the number and angiogenic capacity of CD271+ progenitors was strikingly reduced in insulin resistant donors. Our study highlights the identification of AT- CD271+ progenitors with in vivo superior efficacy for limb ischemia. Furthermore, we showcase comprehensive single-cell transcriptomics strategies for identification of suitable grafts for cell therapy. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

A new research paper was published in Oncotarget's Volume 14 on February 2, 2023, entitled, “Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC).” TP53 mutant head and neck squamous cell carcinoma (HNSCC) patients exhibit poor clinical outcomes with 50–60% recurrence rates in advanced stage patients. In a recent phase II clinical trial, adjuvant therapy with everolimus (mTOR inhibitor) significantly increased 2-year progression-free survival in p53 mutated patients. TP53-driven mTOR activation in solid malignancies causes upregulation of HIF-1α and its target, downstream effector VEGF, by activating STAT3 cell signaling pathway. In this recent study, researchers Md Maksudul Alam, Janmaris Marin Fermin, Mark Knackstedt, Mackenzie J. Noonan, Taylor Powell, Landon Goodreau, Emily K. Daniel, Xiaohua Rong, Tara Moore-Medlin, Alok R. Khandelwal, and Cherie-Ann O. Nathan from LSU-Health Sciences Center investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. “The role of mTOR inhibitors (mTORi) as potent growth inhibitory and antiangiogenic/anti-lymphangiogenic agents in HNSCC is well established [18]. Moreover, mTORi significantly suppressed baseline invasiveness of endothelial and HNSCC tumor cells [19]. However, the underlying molecular mechanisms for mutant p53 protein-mediated activation of the mTOR pathway which drive the oncologic processes in HNSCC are yet to be elucidated.” Treatment with everolimus significantly inhibited cell growth in vitro and effectively reduced the growth of TP53 mutant xenografts in a minimal residual disease (MRD) model in nude mice. Everolimus treatment was associated with significant downregulation of STAT3/HIF-1α/VEGF pathway in both models. Further, treatment with everolimus was associated with attenuation in tumor angiogenesis and lymphangiogenesis as indicated by decreased microvessel density of vascular and lymphatic vessels in HN31 and FaDu xenografts. Everolimus downregulated the STAT3/HIF-1α/VEGF pathway to inhibit growth and in vitro tube formation of HMEC-1 (endothelial) and HMEC-1A (lymphatic endothelial) cell lines. “Our studies demonstrated that everolimus inhibits the growth of TP53 mutant tumors by inhibiting angiogenesis and lymphangiogenesis through the downregulation of STAT3/HIF-1α/VEGF signaling.” DOI: https://doi.org/10.18632/oncotarget.28355 Correspondence to: Cherie-Ann O. Nathan - cherieann.nathan@lsuhs.edu Keywords: TP53 mutant, HNSCC, angiogenesis, everolimus, mTOR About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.19.521008v1?rss=1 Authors: Mary, B., Asokan, N., jerabkova-Roda, K., Larnicol, A., Busnelli, I., Stemmelen, T., Pichot, A., Molitor, A., Carapito, R., Lefebvre, O., GOETZ, J. G., Hyenne, V. Abstract: Extracellular vesicles released by tumors (tEVs) disseminate via circulatory networks and promote microenvironmental changes in distant organs favoring metastatic seeding. Despite their abundance in the bloodstream, how hemodynamics affect the function of circulating tEVs remains unsolved. We experimentally tuned flow profiles in vitro (microfluidics) and in vivo (zebrafish) and demonstrated that efficient uptake of tEVs occurs in endothelial cells subjected to capillary-like hemodynamics. Such flow profiles partially reroute internalized tEVs towards non-acidic and non-degradative Rab14-positive endosomes, at the expense of lysosomes, suggesting that endothelial mechanosensing diverts tEVs from degradation. Subsequently, tEVs promote the expression of pro-angiogenic transcription factors in flow-stimulated endothelial cells and favor vessel sprouting in zebrafish. Altogether, we demonstrate that capillary-like flow profiles potentiate the pro-tumoral function of circulating tEVs by promoting their uptake and rerouting their trafficking. We propose that tEVs contribute to pre-metastatic niche formation by exploiting endothelial mechanosensing in specific vascular regions with permissive hemodynamics. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.07.519382v1?rss=1 Authors: Fraile-Bethencourt, E., Khou, S., Wilson, R., Baris, A., Ruhl, R., Espinosa-Diez, C., Anand, S. Abstract: Endothelial cells are highly responsive to environmental changes that allow them to adapt to intrinsic and extrinsic stimuli and switch their transcriptome accordingly to go back to vascular homeostasis. Our previous data demonstrated that small non-coding-RNAs respond quickly to genotoxic stressors and determined endothelial cell fate and DNA damage response. To further understand the contribution of non-coding-RNAs, we profiled differentially expressed long non-coding RNAs in response to genotoxic stress and compared them to pro-angiogenic growth factor signaling. We identified the Maternally expressed gene 9 (MEG9) as a cytoprotective lncRNA in the endothelium. Gain and Loss-of-function studies indicate that MEG9 prevents endothelial cells from cell death, suggesting that MEG9 responses to genotoxic stress can be an adaptive and protective mechanism. Consistent with this phenotype, the knockdown of MEG9 decreases growth factor-dependent angiogenesis in a 3D fibrin gel angiogenesis assay. Deletion of the MEG9 ortholog, Mirg, in mice results in increased vascular leak in Matrigel plugs and a sex and age-dependent decrease in platelets. Mechanistically, we observed that both MEG9 knockdown in vitro and Mirg-deleted mice in vivo activated common pathways, including apoptosis, clotting, and inflammation. Indeed, the proinflammatory adhesion molecule ICAM1 was significantly increased in human and mouse endothelial cells in a MEG9-dependent manner, supporting the increased vascular permeability observed on MEG9 deficient cells. Taken together, our findings illustrate how genotoxic stress responses through dynamic modulation of lncRNAs, such as MEG9, trigger adaptive mechanisms to maintain endothelial function, while loss of these molecules contributes to maladaptive responses and endothelial cell dysfunction. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.02.518829v1?rss=1 Authors: Fan, Z., Ardicoglu, R., Batavia, A., Rust, R., von Ziegler, L., Waag, R., Zhang, J., Desgeorges, T., Sturman, O., Dang, H., Weber, R., Moor, A. E., Schwab, M. E., Germain, P.-L., Bohacek, J., De Bock, K. Abstract: The molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role of Apold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression of Apold1 is restricted to the vasculature, and that Apold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. Using Apold1-/- mice, we find that Apold1 is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the vascular network in adult brain and muscle. However, when exposed to ischemic conditions following photothrombotic stroke as well as femoral artery ligation, Apold1-/- mice display dramatic impairments in recovery and revascularization. We also find that human tumor endothelial cells express strikingly higher levels of Apold1, and that Apold1 deletion in mice stunts the growth of subcutaneous B16 melanoma tumors, which have smaller and poorly perfused vessels. Mechanistically, Apold1 is activated in ECs upon growth factor stimulation as well as in hypoxia, and Apold1 intrinsically controls EC proliferation but not migration. Our data demonstrate that Apold1 is a key regulator of angiogenesis in pathological settings, whereas it does not affect developmental angiogenesis, thus making it a promising candidate for clinical investigation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.15.516660v1?rss=1 Authors: Shahriar, S., Price, M. Z., Wayne, C. R., Glendinning, M. D., Prochilo, G., Stuhlmann, H., Biswas, S., Menon, V., Agalliu, D. Abstract: Histopathological studies of multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS), and its animal model experimental autoimmune encephalomyelitis (EAE) have found newly formed leaky vessels in demyelinated acute and chronic plaques, in addition to blood-brain barrier damage in existing vessels, that exacerbate disease pathology by increasing CNS infiltration of immune cells. However, which vessel subtypes and signaling pathways generate these aberrant vessels is poorly understood. Using single-cell RNA sequencing and in vivo validation, we find that transcriptome signatures of neo-angiogenesis arise in venous endothelial cells in both acute and chronic EAE, and correlate with upregulation in VEGF-A signaling. These neo-angiogenic markers are also increased in human MS lesions. Treatment with a VEGF-A blocking antibody ameliorates EAE pathology by reducing neo-angiogenic transcriptomic signatures in vivo, suggesting that VEGF-A drives angiogenesis from vein ECs in EAE. Our findings suggest novel therapies targeting the vasculature that could benefit chronic MS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Ligaments are dense fibrous connective tissues that are the attachments that hold bones to other bones. The most commonly injured or talked about is the ACL - Anterior Cruciate Ligament holding the femur to the tibia. Ligaments are formed by about 80% of the extracellular matrix and 20% of fibroblasts. This means the ligament is about 75% collagen, 1% elastin, and glycans. 90% of the collagen is type 1 and 10% is type III.In general, because of this makeup, they have a very poor natural regeneration capacity because of low cell density and nutrient/oxygen requirements. This is why often if complete failure happens replacement or reconstruction is necessary. In recent years, adding growth factors to treatment and healing has been shown to be effective in healing damaged ligaments. The process is usually described as four overlapping sequential stages: inflammatory stage, proliferation stage, remodeling stage, and maturation stage. If you can give support at each phase you can naturally heal and regenerate a ligament or tendon better. At the onset of injuries, hematomas form, and pro-inflammatory cytokines are produced by mast cells which recruit neutrophils, macrophages, and monocytes to the injury site. Angiogenesis is induced by the increased secretion of vascular endothelial growth factor (VEGF). ECM, primarily collagen III, is subsequently synthesized by the recruited fibroblasts at the injury site which is a hallmark of the proliferation stage. During the remodeling stage, ECM production and cell activities are decreased. Collagen III is replaced by collagen I and the collagen fibers start to organize along the direction of tendon stress. At the stage of maturation, the cross-linking of collagen fibrils increases and mature tendonous tissues form with their mechanical strength being gradually improved (Docheva et al., 2015).Inflammatory phase - 2 weeks - Need to get transportation to the area - walk the line - Not too much not too little. This is likely where we are trying to control inflammation and get blood flow to the area. PEMF - Improves vascularization - delivery of healing agents, proteins, and collagens and helps the synthesis of fibroblasts, and repair proteins, a faster healing process is achieved by helping prevent sports-related disabilities and chronic conditions.Cryotherapy - stimulates antiinflammatory responses once past the inflammatory phase and promotes regeneration. A study in 2016 by Ramos et al found that Cryotherapy has a unique ability to Reduces Inflammatory Response Without Altering the Muscle Regeneration Process and the Extracellular Matrix Remodeling of Rat Muscle. Something like an NSAID appears to do both. Intraligament medical needling can reduce mechanical properties and increase blood flow, inflammation, and production of collagen III and glycosaminoglycans compared to the control. Furthermore, mild needling properties returned to or exceeded pre-needling values at the 6-week time point. Clinical significance: Needling the rat supraspinatus tendon is a feasible technique that causes a transient healing responseShockwave for non-healing stimulates tissue inflammation that starts the healing process again. It can improve blood vessel formation, and blood flow as well as accelerated healing activationPeptides: A rat study conducted in 2010 found that BPC-157 lead to the healing of acute ligament injuries within rats.Collagen - needed for proliferation and remodeling Kaatsu - Episode 4 - improves growth factors without significant stress to the tendon or ligament. Remodeling 6 monthsContinue stressing and eccentric loading the joint or area with slow movements at least 3x/week and decreasing to 1x/week by 6 months but don't stop! Maturation - 2 yearsContinue to increase strength in the area and work on the stability, mobil

Hello everybody and welcome to the Heath Upgrade PodcastIn today's episode, we have a very interesting topic which is the complex tie between macrophages and angiogenesis, in both health and in disease, as well as the development and production of the network of blood vessel in angiogenesis. Angiogenesis is the process by which we produce new blood vessels and macrophages plays an important role in the production and maintenance of these blood vessels which is why they are a pair. Without macrophages, our blood vessel will not form in the correct pattern, and those connections of the vasculature structure will not be created correctly. We can say that macrophages are the core of the creation of the blood vessel.We'll also touch on the peripheral vascular disease, chronic inflammation, iron homeostasis and the process of angiogenesis and macrophages which is linked with that.Rate and review before the next episode. If you want to know more about us and what we do, go to www.healthupgradepodcast.com.  Contact info:       Navaz Habib  Email: podcast@healthupgraded.com  Facebook: https://www.facebook.com/DrNavazHabib/  Instagram: https://www.instagram.com/drnavazhabib/  LinkedIn: https://ca.linkedin.com/in/drnavazhabib    JP Errico  LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa   

Dr Yvonne Couch, narrates her blog written for the Dementia Researcher website. Angiogenesis is the formation of new blood vessels - this process involves the migration, growth, and differentiation of endothelial cells, which line the inside wall of blood vessels. Todays blog by Yvonne is all about Angiogenesis, a bit of history and a bit of how angiogenesis after brain injury and in old age may contribute to brain health. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-angiogenesis/ -- Dr Yvonne Couch is an Alzheimer's Research UK Fellow at the University of Oxford. Yvonne studies the role of extracellular vesicles and their role in changing the function of the vasculature after stroke, aiming to discover why the prevalence of dementia after stroke is three times higher than the average. It is her passion for problem solving and love of science that drives her, in advancing our knowledge of disease. Yvonne has joined the team of staff bloggers at Dementia Researcher, and will be writing about her work and life as she takes a new road into independent research. _____________________________________________________ Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk

Dr. Ron Hunninghake, MD, Chief Medical Officer, and Dr. Lucas Tims, ND, FABNO, continue their discussion about the terrain approach to integrative oncology in this episode of the Real Health Podcast. Today's episode features two of the 10 terrains: inflammation and angiogenesis. Dr. Ron and Dr. Lucas explain how these two terrains can work in both good and harmful ways and what steps patients can take to help control them.

Did you know that your body can fight off diseases if you eat the right foods? Learn about the 5x5x5 framework and how you can feed your five defenses correctly. Join Corinna Bellizzi as she reviews Dr. William Li's bestselling book and course of the same name: Eat to Beat Disease: The New Science of How Your Body Can Heal Itself. Discover how your body heals itself with stem cells. Learn the best foods to eat while still having some cheat foods. This podcast episode marks the launch of a four-week series reflecting on Dr. William Li's New York Times bestseller, Eat To Beat Disease: The New Science of How Your Body Can Heal Itself and his online course of the same name. This series springboards from our interview with Dr. Li, which was episode #3. Relevant Past Episode:Interview with Dr.William Li: https://orlonutrition.com/blogs/podcast/eat-to-beat-disease-how-your-body-can-heal-itself-with-the-right-nutrition-with-dr-william-w-li-physician-and-nyt-bestselling-authorABOUT “EAT TO BEAT DISEASE”:Eat your way to better health with this New York Times bestseller on food's ability to help the body heal itself from cancer, dementia, and dozens of other avoidable diseases. Forget everything you think you know about your body and food and discover the new science of how the body heals itself. Learn how to identify the strategies and dosages for using food to transform your resilience and health in Eat to Beat Disease.We have radically underestimated our body's power to transform and restore our health. Pioneering physician-scientist, Dr. William Li, empowers readers by showing them the evidence behind over 200 health-boosting foods that can starve cancer, reduce your risk of dementia, and beat dozens of avoidable diseases. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems.The book's plan shows you how to integrate the foods you already love into any diet or health plan to activate your body's health defense systems-Angiogenesis, Regeneration, Microbiome, DNA Protection, and Immunity-to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions. https://drwilliamli.com/book-li/About Dr. William Li:William W. Li, MD, is an internationally renowned physician, scientist, and author of the New York Times bestseller “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.” His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease, and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC, and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic, and O Magazine. He is president and medical director of the Angiogenesis Foundation and is leading research into COVID-19.Sign up for his masterclass: https://drwilliamli.com/masterclass/Sign up for the paid course: https://eat-to-beat-disease.teachable.com/p/fullprice

Bio: William W. Li, MD, is an internationally renowned physician, scientist and author of the New York Times bestseller “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.” His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic and O Magazine. He is president and medical director of the Angiogenesis Foundation and is leading research into COVID-19.  ABOUT “EAT TO BEAT DISEASE”: Eat your way to better health with this New York Times bestseller on food's ability to help the body heal itself from cancer, dementia, and dozens of other avoidable diseases.  Forget everything you think you know about your body and food, and discover the new science of how the body heals itself. Learn how to identify the strategies and dosages for using food to transform your resilience and health in Eat to Beat Disease. We have radically underestimated our body's power to transform and restore our health. Pioneering physician scientist, Dr. William Li, empowers readers by showing them the evidence behind over 200 health-boosting foods that can starve cancer, reduce your risk of dementia, and beat dozens of avoidable diseases. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems. The book's plan shows you how to integrate the foods you already love into any diet or health plan to activate your body's health defense systems-Angiogenesis, Regeneration, Microbiome, DNA Protection, and Immunity-to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions.  https://drwilliamli.com/book-li/ ABOUT THE MASTERCLASS: Join world renowned scientist, physician, and New York Times bestselling author Dr. William Li as he shares his wealth of knowledge and research that has impacted more than 50 million lives. Dr. Li is a true pioneer in food as medicine and has discovered more than two hundred foods that activate the body's hardwired health defense systems: angiogenesis, regeneration, microbiome, DNA protection, and immunity. During this sixty minute free masterclass Dr. Li will break down each of the health defense systems to help you understand the basis of how they function and then share specific foods that you can use to activate each one. These are the same foods that Dr. Li has studied in detail to understand their abilities to combat and prevent things like cancer, cardiovascular disease.  https://drwilliamli.com/masterclass/ Miso Salad Dressing Makes enough for 2 salads Ingredients 2 Tbs. Miso 2 Tbs. Orange Juice 1 Tbs. minced ginger ½ t. minced garlic 1-½ Tbs. Rice Vinegar 1 t. tamari 1 Tbs. safflower oil 1 t. maple syrup 1 t. sesame oil 2 Tbs. Tahini 1 Tbs. Lemon Juice Add all ingredients into Mini Food Processor and process until smooth.

Join me and my good friend and guest Dr. William Li, physician, scientist, president and medical director of the Angiogenesis Foundation, and author of the New York Times Best-Seller Eat To Beat Disease: The New Science of How Your Body Can Heal Itself. His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic and O Magazine.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we talk about a study called, "Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue", published in 2019. Mentioned in this episode: Lipedema & Lymphedema Heart to Heart: A Collaborative 3-Day Learning Event Join us for three days full of immersive learning and discover cutting-edge holistic strategies that would help to drastically improve your health... and your quality of life. https://lipedema.captivate.fm/heart2heart (Join our Event!)

Plantar Fasciitis Shockwave TherapyPlantar Fasciitis New Treatment Using Shockwave TherapyShockwave treatment for Plantar Fasciitis, additionally called jogger's foot utilizes acoustic waves to separate mini attachments that develop in the muscle mass as well as ligaments of the reduced leg as well as foot. Attachments are quite like mark cells. When the mark cells appears it interrupts the typical matrix of muscle mass cells. This develops an excruciating problem additionally called Runner's Foot. Muscular tissue fibers indicated to relocate openly are currently limited as well as acquired. Over a long term time, the muscular tissue fibers end up being topsy-turvy including even more discomfort and also limitation of typical movement.Shockwave Plantar Fasciitis just how it functionsThe shockwave is acoustical in nature. The waveform developed sends out harmed Plantar Fasciitis muscle mass focused power to deal with severe as well as persistent foot and also heel discomfort triggered by Plantar Fasciitis. The discomfort is eased by numerous systems;Angiogenesis- the development of new members vesselsImproved Collagen manufacturing to reinforce connective cellsMobile Response to microtrauma creates raised ATP manufacturingLiquifies agonizing attachments in the fasciaUrges stem cell manufacturing (this has actually not been confirmed by FDA).What is Plantar Fasciitis?Plantar Fasciitis discomfort results from the swollen fascia under of the foot. It additionally entails numerous muscular tissues frequently called Tom, Dick, and also Harry. It generally impacts 1 out of 10 individuals eventually in their life. The cautious focus must be paid to the Tibialis Posterior, Flexor Hallicus Longus, and also Flexor Digitorum Longus. These are described as Tom, Dick, and also Harry muscle mass. This is an anacronym of the extensive provided names. These couple of muscular tissues link to nearly every bone in the foot. When these muscular tissues are attended to in enhancement to the plantar surface area of the foot, shockwave therapy for plantar fasciitis is a lot a lot more reliable.Why Core Health Darien for Plantar Fasciitis Shockwave?Dr. Mc Kay has actually examined the biomechanical marvel called the foot for over 20 years. He is among just a handful of chiropractic physicians learned to readjust the feet. By rearranging several of the 27 bones in the foot we can offer even more security to the longitudinal as well as median arcs of the foot. When dealing with Runner's Foot, the duty of muscle mass, as well as ligaments that add to plantar fasciitis, needs to be taken into consideration as well. By resolving the discomfort from a biomechanical strategy as well as incorporating that with shockwave treatment Core Health Darien can provide a quicker resolution of discomfort related to Plantar Fasciitis. We generally see outcomes within 8-12 therapies.

Shockwave Treatment New Method to Deal With Bad Back PainWhat is Shockwave Therapy?Shockwave Therapy is a therapy that is being made use of to speed up healing from bone and joint injuries. A fascinating note is that shockwave treatment in orthopedics initially obtained its begin as a therapy to break up kidney stones. Basically the exact same treatment is currently being utilized for an entire host of orthopedic conditions.You have persistent discomfort in your lower back. You attempt massage therapy, perhaps take a couple of Aleve which should care for it? When the discomfort comes to be extra significant do you take into consideration chiropractic treatment or physical treatment? When that does not function what do you do beside treat your pain in the back? Well, the bright side is you have an alternative. It is called Shockwave Therapy. Yes, it seems frightening however if you think of it there is something to it if you have persistent discomfort or an injury that will not recover.What Does ShockWave Treat?Achilles tendinitisPatellar tendonitisQuadriceps tendinitisSide epicondylitis/tennis elbow jointMedian epicondylitis/golfer's jointBiceps/triceps tendinitisPartial-thickness potter's wheel cuff splitsTrochanteric tendonitisPlantar fasciitisShin splintsMuscular tissue Spasmslower Back PainScientific Research Behind Shockwave TherapyShockwave Therapy is specified as a wave with a fast boost of stress within an extremely brief refactory time and afterwards having a progressive decline of stress with a little unfavorable stress stage.The shockwaves produced have countless peer-reviewed advantages with really couple of adverse effects.Discomfort decrease is most likely the greatest advantage of Shockwave Therapy. One method it reduces discomfort is by enhancing cell membrane layer passage by boosting the cell's leaks in the structure with ionic networks.Just how does Shockwave operate in the body?Nitric oxide manufacturing seems boosted by Shockwave Therapy. NO2 (Nitric Oxide) has the capacity to expand capillary. This permits even more blood circulation which permits the dissolution of toxic substances that collect in a hurt location. Extra blood quicker recovery. Angiogenesis is one more included advantage because the shockwaves boost your body to generate even more arteries in the therapy location. When treated with shockwave treatment permitting it to recover quicker, basically the hurt location has actually boosted metabolic rate.Is Shockwave Therapy Painful?When dealing with a hurt body component making use of Shockwave Therapy, there can be some pain. The shockwaves liquify lactic acid that often tends to swimming pool in muscle mass that are worn or wounded. The waves generated additionally permit broken cells to be gotten rid of by the blood vessels. There is a little discomfort yet we frequently see faster recovery times. Individuals with tennis elbow can begin to return to typical play in a couple of brief weeks. Somebody with a persistent lower back pain concern can begin extra hardcore physical treatment after a couple of sessions. Below ia an excellent way to consider shockwave treatment. After that Shockwave is a means to obtain over the obstacle to begin significant recovery, if the soft cells is not reacting.Is Shockwave Therapy covered by Insurance?Shockwave is not covered by insurance coverage. That might transform as insurer see it as a method to conserve

Did you know that your body can fight off diseases if you eat the right foods? Learn about the 5x5x5 framework and how you can feed your five defenses correctly. Join Corinna Bellizzi as she connects with Dr. William W. Li, MD, who is the bestselling author of Eat to Beat Disease. Discover how your body heals itself with stem cells. Learn the best foods to eat while still having some cheat foods. And, join his free masterclasses to learn more of what you'll learn today! About Guest:William W. Li, MD, is an internationally renowned physician, scientist, and author of the New York Times bestseller “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.” His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease, and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC, and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic, and O Magazine. He is president and medical director of the Angiogenesis Foundation and is leading research into COVID-19. https://www.instagram.com/drwilliamli/ - Guest LinkedInhttps://drwilliamli.com - Guest Websitehttps://twitter.com/drwilliamli - Guest Twitterhttps://www.youtube.com/c/DrWilliamLi - Guest YouTubehttps://drwilliamli.com/masterclass/ - Guest Masterclass Show Notes:3:53 - Introduction6:04 - Why Write A Book?11:43 - Defining Health17:28 - Finding The Good Foods23:52 - The Study Of Steam Cells30:37 - The 5x5x5 Framework36:14 - Dr. William W. Li's Masterclass42:06 - What Did You Learn? ABOUT “EAT TO BEAT DISEASE”:Eat your way to better health with this New York Times bestseller on food's ability to help the body heal itself from cancer, dementia, and dozens of other avoidable diseases. Forget everything you think you know about your body and food and discover the new science of how the body heals itself. Learn how to identify the strategies and dosages for using food to transform your resilience and health in Eat to Beat Disease. We have radically underestimated our body's power to transform and restore our health. Pioneering physician-scientist, Dr. William Li, empowers readers by showing them the evidence behind over 200 health-boosting foods that can starve cancer, reduce your risk of dementia, and beat dozens of avoidable diseases. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems. The book's plan shows you how to integrate the foods you already love into any diet or health plan to activate your body's health defense systems-Angiogenesis, Regeneration, Microbiome, DNA Protection, and Immunity-to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions. https://drwilliamli.com/book-li/Love the show? Subscribe, rate, review, & share! https://caremorebebetter.com And join the Care More Be Better Community!YouTube: https://www.youtube.com/c/caremorebebetter Instagram: https://www.instagram.com/CareMore.BeBetter/ Facebook: https://www.facebook.com/CareMoreBeBetter LinkedIn: https://www.linkedin.com/company/care-more-be-better Twitter: https://twitter.com/caremorebebetter Clubhouse: https://www.clubhouse.com/club/care-more-be-better Support Care More. Be Better: A Social Impact + Sustainability PodcastCare More. Be Better. is not backed by any company. We answer only to our collective conscience. As a listener, reader, and subscriber you are part of this pod and this community and we are honored to have your support. If you can, please help finance the show: https://caremorebebetter.com/donate. Thank you, now and always, for your support as we get this thing started!

Dr. Kenta Nakamura joins us on this week's episode to discuss the history of stem cell research and how he plans to help lead it into the future.   His educational foundation in stem cell biology has intersected with an interventional clinical focus at UW Medicine to now lead a new clinical trial with human vascular endothelial growth factor (VEGF) to induce therapeutic angiogenesis (revascularization).  Episode topics:0:38 - Stem Cell Biology and Interventional Cardiology Career3:55 - Rocky Road of Stem Cell Therapies 9:25 - Thoughtful process of new clinical trials10:20 - Techniques and delivery of stem cells17:50 - Diagnostically measuring success21:43 - EXACT Clinical Trial - Refractory Angina 26:20 - Patient Criteria32:20 - Potential for Young Patients 37:29 - Motivation for Medicine39:47 - Advice for Translational Basic Science Careers43:28 - Outside of work45:50 - Referrals for Trialhttps://clinicaltrials.gov/ct2/show/NCT04125732@KentaMDnakamur@uw.edu

References Journal of Biological Chemistry.2013. 288 Issue 52 Pages 37355-37364. Prostaglandins & Other Lipid Mediators. 2022(April) . Volume 159, 106621 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

What is angiogenesis, and why should you care? Come listen in and find out! It is a common denominator of a lot of diseases of aging, and you can influence it to play nice within your body by the things you choose to eat. Little moment to moment choices in your life really do make a difference in your ability to live a long and healthy life.Great Book and website By Dr William Li: https://www.eattobeat.org/Grab These Free Resources:Guide to be ready before you get sick: https://healthcourage.ck.pageMP3 Audio of empowering questions to reprogram your subconscious: https://healthcourage.ck.page/questionsGuide to capitalize on the hormonal advantages of different phases of your menstrual cycle: https://healthcourage.ck.page/cycle

Hyperbaric chambers use pressure, and in some cases concentrated oxygen, to treat a wide variety of injuries and ailments. You've no doubt heard of high-level athletes using these treatments to speed up recovery, but you might not realize hyperbaric therapy is approved for 14+ medical conditions.  On this week's podcast, we'll explore the safe and simple use of pressurized therapy for reduced inflammation, oxygenation of plasma, fighting off infections, and more.  Listen and learn:  How pressure increases oxygen-rich plasma for health and healing How pressure vasoconstricts and reduce inflammation Angiogenesis effects (new blood vessel formation) Appropriate use and pressure levels based on treatments Risks, rewards, and unknowns in regards to long-term use Links Dr. Sherr's website  ABOUT OUR GUEST Dr. Scott Sherr is the director of Integrative Hyperbaric Medicine and Heath Optimization at Hyperbaric Medical Solutions where he develops personalized treatment plans for patients.  Nutritional Tip of the Week Best Breakfast Like the Show? Leave us a Review on iTunes 

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Aging-US published a Special Collection on Eye Disease which included "miR-106b suppresses pathological retinal angiogenesis" which reported that microRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Here, the authors show that expression of the miR-106b-25 cluster is negatively regulated by the unfolded protein response pathway of protein kinase RNA-like ER kinase in a mouse model of neovascular AMD. They demonstrate that therapeutic delivery of miR-106b to the retina with lentiviral vectors protects against aberrant retinal angiogenesis in two distinct mouse models of pathological retinal neovascularization. Dr. Przemyslaw Sapieha and Dr. Vincent De Guire said, "Age-related macular degeneration (AMD) is a common [1] and complex [2, 3] disease of aging and the leading cause of irreversible loss of sight in elderly people." Early forms of AMD are characterized by subretinal lipoproteinaceous deposits, local attrition of photoreceptors and loss of visual sensitivity. Late forms of AMD are defined by geographic atrophy and/or pathologic choroidal neovascularization characterized by vascular sprouting from the choriocapillaris into the neural retina or subretinal space. Sustained reduction in retinal VEGF levels can lead to neurotoxicity and degeneration of RPE-choriocapillaris in mouse models. Importantly, assessment by fundus photography and fundus fluorescein angiography of patients on anti-VEGF therapy showed accelerated development of geographic atrophy. These findings justify the need for continued exploration of novel therapeutic interventions. Given that several inflammatory and growth factors in addition to VEGF are associated with the pathogenesis of NV AMD, a multi-targeted approach is warranted. The authors previously elucidated a specific miRNA signature in the vitreous and plasma of patients with NV AMD and observed a disease-associated increase in miR-146a and a decrease in miR-106b and miR-152. Interestingly, within this cohort, they found that both vitreous- and plasma-based miR-146a/miR-106b ratios had greater than 90% discriminatory power for classification of patients with NV AMD with an area under the receiver operating characteristic curve of 0,977 in vitreous humour and 0,915 in plasma, suggesting potential for a blood-based diagnostic. The Sapieha/De Guire Research Team concluded in their Aging-US Research Output that there are efforts to devise therapeutics that simultaneously inhibit several factors involved in retinal vascular disease given the clinical success of compounds such as Aflibercept. miRNAs regulate translation of multiple genes and hence may be considered as multi-target inhibitors. Their potential to mitigate retinal disease will grow as comprehensive landscapes of miRNAs in health and disease are established. Preclinical studies are underway for mimics or inhibition of specific miRNAs. Full Text - https://www.aging-us.com/article/202404/text Correspondence to: Przemyslaw Sapieha email: mike.sapieha@umontreal.ca and Vincent De Guire email: vdeguire.hmr@ssss.gouv.qc.ca Keywords: age related macular degeneration, miR-106b, PERK, choroidal neovascularization, angiogenesis About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways. To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

Ashton and Madison discuss life happenings and then dive into the realms of True Crime and Angiogenesis!