Podcasts about Angiogenesis

In this episode of "Clinical Unfiltered," Dr. Sausha delves into the intricacies of bone grafting, focusing on the critical PASS Principles: Primary wound coverage, Angiogenesis, Space maintenance, and Stability. Dr. Sausha shares insights from a significant case involving a young patient with a severe vertical defect, illustrating how these principles guide successful grafting outcomes. Listeners will gain a deeper understanding of the techniques and considerations necessary for effective bone regeneration, including the use of custom titanium meshes and advanced suturing methods.

Dr. Abud Bakri, MD, is a board-certified internal medicine physician and expert in the science and clinical use of peptides. We discuss the history, uses, sourcing and safety of BPC-157, GHK-Cu, pinealon, epithalon, GLP-1s, retatrutide, melanotan and growth hormone-promoting peptides. We discuss the gap that exists between animal and human data and meaningful differences in the sources for different peptides. For those interested in peptides, Dr. Bakri provides a grounded look at the science, risks and uncertainties shaping the field today. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Lingo: https://hellolingo.com/huberman Function: https://functionhealth.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (00:00:00) Abud Bakri (00:03:33) What are Peptides?, Receptors (00:06:26) BPC-157, Discovery, Animal Proteins (00:11:19) BPC-157, Animal Data, Regeneration (00:12:27) Sponsors: Eight Sleep & Lingo (00:14:51) BPC-157, Regeneration & Healing, Neurological Effects (00:19:27) Adverse Events, Clinical Trials & Legality of BPC-157 (00:29:41) GLPs & Compounding Pharmacy; Peptides & Gray Market (00:35:25) Manufacturing, Compounding Pharmacies, Gray Market, Black Market (00:41:32) Peptides & Tumor Growth?; Angiogenesis (00:45:17) Sponsor: AG1 (00:47:01) Pharmaceutical Patents, Clinical Trials for BPC-157, Potential Outcomes (00:54:19) BPC-157 Healing, Patient Experiences (01:01:22) Physician Counsel, FDA Legality, Malpractice (01:07:25) Pinealon, Epithalon, Discovery; Sleep & Cognitive Performance, Risks (01:18:17) Sponsor: Function (01:19:55) Pineal Age Deterioration, Epithalon, Eye Health (01:29:38) Thymus, Age Shrinkage; Thymosin Alpha-1, Immune Function (01:38:13) TB-500; Pet Health; Thymic Peptide Doses, Thymulin, Zinc (01:49:13) Sponsor: LMNT (01:50:33) GHK-Cu (Copper GHK), Collagen (01:55:32) Illness Recovery, Thymic Score, Tool: Blood Test & Immune Cell Counts (02:04:01) Growth Hormone Secretagogues, Age Decline, Cancer Risk, Insulin (02:15:36) GHK-Cu, Topical Cream, Red Light Therapy (02:20:25) GLPs, Discovery, Physical & Cognitive Long-Term Effects, Fertility (02:33:53) Retatrutide; Drug Patents & Nomenclature (02:39:03) Peptides: Women Reproductive Disorders; TBI, Neurologic Effect; Safe Sources (02:45:34) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Hyperbaric Oxygen Therapy (HBOT): Beyond the Bends—Wounds, Stroke Recovery, Radiation Injury, and Performance. Nicole Garrett, founder and COO of Under Pressure Hyperbarics, details hyperbaric oxygen therapy (HBOT). She explains how HBOT treats divers' decompression sickness by recompressing nitrogen bubbles and reducing inflammation, and how therapeutic benefits depend on reaching adequate pressure (commonly around 2.0 atmospheres or more; diver treatment may begin at 2.8). Garrett describes HBOT's history, FDA-approved uses such as diabetic wound healing, radiation injury, and sudden sensorineural hearing loss (often combined with steroids), and off-label use for stroke/TBI recovery, cognitive issues, autoimmune flares, Crohn's disease, athletic recovery, anti-aging research (including telomere findings), and adjunctive cancer care. She contrasts “soft” chambers with higher-pressure medical chambers, discusses treatment courses (often 10–60 sessions), safety and contraindications (ears, pneumothorax, retinal bubble procedures), and practical barriers like cost, insurance coverage, and facility/oxygen regulations.

Broadcast from KSQD, Santa Cruz on 5-07-2026: Dr. Dawn debunks the 1971 "220 minus age" maximum heart rate formula, noting a 2025 study found individual predictions were off by up to 20 beats per minute. She recommends the Tanaka equation (208 minus age) times 0.7, but emphasizes tracking improvement trends rather than absolute numbers. ConsumerLab testing found Safe Catch Wild Elite Pure Tuna and Wild Ahi Yellowfin Tuna had no detectable mercury, prompting Dr. Dawn to reconsider eating tuna after years of avoidance due to concerns about mercury bioaccumulation and its effects on nerve microtubules. A meta-analysis of 115 studies involving 55,000 men found limiting ejaculation before IVF leads to increased sperm DNA damage and poorer motility. Clinical trials showed 46% IVF pregnancy rates with less than 48 hours abstinence versus 36% with longer periods. A personalized mRNA vaccine for pancreatic cancer showed striking results: of 16 patients whose tumors were surgically removed, half produced killer T-cells targeting cancer, and seven of those eight remain alive six years later. Pfizer and Valneva's Lyme disease vaccine reduced infection by over 70% in a trial of 9,400 people ages five and up. Nearly half a million Americans contract Lyme annually, and chronic infection can cause nervous system damage and chronic fatigue. Dr. Dawn explores the gray-market peptide ecosystem, where compounds are sold as "research chemicals" with wink-and-nod marketing. A 2018 Belgian study found purity levels ranging from 5% to 99.9%, with some samples containing arsenic, lead, or industrial contaminants. A study of 450 people found that blocking smartphone internet access for two weeks improved sustained attention equivalent to reversing 10 years of age-related cognitive decline, with depression symptom improvements comparable to cognitive behavioral therapy. A multi-country study of 241 unresponsive patients found that 25% showed brain activity indicating consciousness when asked to imagine playing tennis during advanced brain scans. Scientists call this cognitive motor dissociation, and by some estimates tens of thousands of Americans may be misdiagnosed. Chinese researchers grew functional adrenal cortex organoids that responded to pituitary hormones and produced cortisol when transplanted into mice. They also introduced genetic mutations to create organoid models of Cushing's syndrome for drug testing. A Science paper identified the neural pathway connecting psychological stress to eczema flare-ups: sympathetic neurons from the stellate ganglion recruit eosinophils to the skin. Researchers traced the pathway using pseudo-rabies virus injected into skin. Mouse studies showed prenatal stress causes elevated corticosterone in amniotic fluid, which activates fetal mast cells derived from the yolk sac. Offspring develop eczema-like lesions in areas receiving mechanical stimulation, but symptoms resolve around 24 weeks when bone marrow-derived mast cells replace the activated ones. Callers ask about CBN side effects. Dr. Dawn explains cannabinoids prolong anandamide's calming effects by slowing its breakdown, and considers 30-45mg over a night reasonable, but cautions against escalating doses given limited research.

EECP Therapy and Stroke Recovery: Can a Cardiac Treatment Help Grow New Blood Vessels? When I first heard about EECP therapy in the context of stroke recovery, I was skeptical. It’s a cardiac device approved in Australia for stable angina and congestive heart failure. Stroke is not on the label. So why are we talking about it on a stroke recovery podcast? Because the mechanism is fascinating. And the research, while still emerging, is pointing somewhere worth paying attention to. In this episode, I sat down with Jack Clifford, a heart disease patient who discovered EECP therapy and began exploring its potential beyond its approved indications. What started as a cardiac conversation quickly became one of the most scientifically interesting discussions I’ve had on the show. What Is EECP Therapy? EECP stands for Enhanced External Counterpulsation. The treatment involves a set of pneumatic cuffs fitted around the calves, thighs, and buttocks. These cuffs inflate and deflate in precise synchrony with the heartbeat, inflating during the heart’s resting phase (diastole) to push blood back toward the heart, and deflating just before the heart contracts. The result is an increase in blood flow and a specific type of fluid shear stress on blood vessel walls. It’s that shear stress that makes things interesting. The Biology: Arteriogenesis and Angiogenesis To understand why EECP therapy might be relevant to stroke survivors, you need to understand two terms: angiogenesis and arteriogenesis. Angiogenesis is the sprouting of entirely new capillary vessels — the body builds small blood channels where none existed before. Arteriogenesis is different: it’s the remodelling of pre-existing, dormant collateral vessels into functional bypass channels. Think of it like upgrading a dirt track into a highway. The track was always there; the body just wasn’t using it. When blood flow is obstructed, whether by a blocked coronary artery or a stroke, the body can, under the right conditions, activate these collateral pathways. The shear stress produced by EECP therapy appears to be one of the triggers that stimulate arteriogenesis. By generating repeated waves of increased blood flow, the treatment creates the mechanical signal that tells blood vessel walls to grow and remodel. This is why cardiac researchers originally developed EECP for heart patients. But it raises a legitimate scientific question: could the same mechanism support blood flow recovery in the brain after stroke? What Does the Research Say? A 2026 meta-analysis published in the QJM: An International Journal of Medicine examined 15 randomized controlled trials involving 506 participants, looking specifically at EECP’s effects on functional outcomes in stroke patients. The results showed statistically significant improvements, with EECP outperforming control conditions on standard functional recovery measures. This is preliminary evidence, not a settled clinical consensus. The studies are relatively small, the methodology varies across trials, and EECP remains off-label for stroke in Australia. But for a therapy with a well-understood safety profile and an existing approval framework, 15 studies and 506 participants is not nothing. It’s enough to warrant serious discussion. What I Discussed with Jack Clifford Jack came to EECP as a patient, not a researcher. His experience with heart disease led him to explore the therapy, and he’s spent considerable time understanding the evidence base and connecting with practitioners. He’s not a clinician, and neither am I, but what we can do together is examine what the research actually says, what the mechanism actually is, and what questions remain unanswered. In our conversation, we discussed: How Jack first encountered EECP therapy and what led him to investigate it further The difference between approved and off-label use, and why that distinction matters What the shear stress mechanism actually looks like in practice The existing network of EECP practitioners and how stroke survivors might access the therapy The questions both of us still have about where the research needs to go Important Disclaimers   EECP therapy is approved in Australia by the TGA for stable angina pectoris and congestive heart failure (ARTG Entry 376470). Stroke is NOT an approved indication. This article and podcast episode are not medical advice. Speak with your treating physician before pursuing any treatment. This episode is not medical advice. It is a conversation about an area of emerging research that I find scientifically credible and worth understanding. The goal is to help you ask better questions, not to tell you what treatment to pursue. Where to Learn More ecplocator.com a directory of EECP therapy providers eecpbook.com is a dedicated resource on the treatment and its evidence base recoveryafterstroke.com for stroke survivors looking for a broader community Research cited: Zhao et al. (2026). Enhanced external counterpulsation for ischaemic stroke: a systematic review and meta-analysis. QJM: An International Journal of Medicine. DOI: 10.1093/qjmed/hcag010. Therapy and Stroke Recovery: Can a Cardiac Treatment Help Grow New Blood Vessels? Bill Gasiamis sits down with Jack Clifford to explore EECP therapy, a TGA-approved cardiac treatment that may stimulate the growth of new blood vessels. Together, they examine the emerging research on angiogenesis, arteriogenesis, and whether this off-label approach holds promise for stroke survivors seeking to improve blood flow to the brain. Highlights: 00:00 Introduction – EECP Therapy06:06 Recognizing Health Issues and Seeking Help09:50 Hospital Experience and Heart Health12:12 Decisions Against Medical Advice16:28 Exploring Alternative Treatments18:06 Understanding Enhanced External Counter Pulsation (EECP)21:58 The Mechanism of EECP27:03 Personal Transformation Through EECP30:29 Lifestyle Changes and Holistic Health34:35 The Impact of Stress on Health38:30 The Journey of Writing a Book43:29 The Role of EECP in Heart Health48:21 Raising Awareness for EECP Therapy56:05 Exploring the Future of EECP Therapy Transcript: Introduction – EECP Therapy Jack Clifford (00:00)Mine was really severe. 100 % blocked in my widow maker, the left anterior descending. I’m 95 in my left coronary artery and in my right main, I am 80%. And I’m still that way today, but I can run a sub seven mile. Bill Gasiamis (00:16)Welcome to the Recovery After Stroke podcast. I am your host, Bill Gassiamus. Before we get into today’s interview, I need to share something important. The topic we’re exploring today involves a medical device called an EACP, Enhanced External Counterpulsation Machine. In Australia, EACP is registered with the Therapeutic Goods Administration for the treatment of stable angina and congestive heart failure. It is not approved for stroke. What we are discussing today is emerging off-label research, not a treatment recommendation. Everything in this episode is for informational purposes only. This is not medical advice. Please speak with your treating physician before pursuing any treatment, therapy or intervention discussed here. With that said, let’s talk about something that genuinely fascinated me when I started reading the research. Your body has the capacity to grow new blood vessels, not just small capillaries, but to remodel dormant pre-existing channels into functional bypass routes. Scientists call this arteriogenesis. There’s also angiogenesis, the sprouting of entirely new Both processes matter deeply for stroke because stroke is fundamentally a blood flow problem. Now here’s where it gets interesting. A cardiac therapy developed for heart patients, not stroke patients, trigger exactly this kind of vascular remodeling. And in 2026, a meta-analysis published in the QJM across 15 randomized controlled trials and 506 participants found that EECP produced statistically significant improvements in functional outcomes for ischemic stroke patients. Now, that’s not proof. That’s not a green light to go and get an EECP, but it is worth a serious conversation. My guest today is Jack Clifford. Jack is a heart disease patient who discovered EECP therapy while managing his own cardiac condition and who has since spent considerable time investigating its potential. beyond cardiac care. I should tell you, I was skeptical going into this conversation, but I’ve learned that skepticism without curiosity isn’t really skepticism. It’s just closed mindedness. So I read the research and then I sat down with Jack. So if you find this episode valuable, I’d love for you to grab a copy of my book, The unexpected way that a stroke became the best thing that happened at recoveryafterstroke.com/book. And if you want to support the show, you can join Patreon at patreon.com/recoveryafterstroke. And I want to thank everyone who is supporting me on Patreon, especially the people that have been around for a long time and the people who have just recently signed up. I very much appreciate it. And now here’s my conversation with Jack Clifford. Bill Gasiamis (03:19)Welcome to the podcast. Jack Clifford (03:22)Thanks, Bill. Great to be here. Bill Gasiamis (03:24)Let’s give the listeners a bit of a background understanding of why you’re on the podcast. You’re not a stroke survivor, but we have something in common as ⁓ somebody who has been unwell before myself and you in the past. Tell me a little bit about your journey to the podcast So we just kind of give people an understanding as to how it is that somebody who’s not a stroke survivor. Jack Clifford (03:34)We do. Bill Gasiamis (03:51)how we ended up chatting together? Jack Clifford (03:54)Yeah, absolutely. So the quick version here is ⁓ I was on the brink five years ago of having ⁓ unsentable emergency triple bypass surgery. And ⁓ I chose a different path, which we’ll get to. ⁓ But you you have some level of placking if you have a stroke, typically, depends on the stroke, but that’s typically the case. And in my case, I had placking in my coronary arteries. So it resulted in heart disease. Mine was really severe. 100 % blocked in my widow maker, the left anterior descending. ⁓ I’m 95 in my ⁓ left coronary artery and in my right main, I am 80%. And I’m still that way today, but I can run a sub seven mile. I can do some things that a guy that’s as blocked up as that should not theoretically be able to do. ⁓ Bill Gasiamis (04:49)All right. Tell me about life before the injury. What kind of work did you do? How did you go about life? What was generally a day like for you? Jack Clifford (04:59)Yeah. So I’m retired military guy. Um, so, you know, been in the military most of my life, um, retired about 10 years ago, a little over that. And, um, so I’ve always been a pretty fit guy. It wasn’t, you know, it wasn’t a fitness issue per se. Um, and, uh, I, I, I had kind of lost some of my self care because my wife had been going through some real significant medical issues that really required my full attention for quite a while. And because of that, really stopped taking care of myself in the ways I had in the past for about 10 years. And when we had just moved to Florida, I started trying to take care of myself again. And that’s when I discovered all these problems. Bill Gasiamis (05:44)So what does not taking care of yourself look like though? Jack Clifford (05:47)Gotta be in a couch potato and being on my computer way too much research and for ⁓ trying to help my wife get better and hold down a job at the same time and raise a family and all these other things that took the priority off of me in that sense that one should be taking care of themselves, meaning exercising, meaning eating the right foods, so on and Recognizing Health Issues and Seeking Help Bill Gasiamis (06:09)You know, caregivers tend to die before the person they’re caring for much more often. And it’s cause of that reason, right? Because time is really taken up by especially full-time caregiving with somebody’s in the house and they need caregiving. need care. The caregiver tends to neglect themselves in every way, shape and form and tends to ⁓ make it about the other person. And then the other person. Jack Clifford (06:14)I’ve seen that and heard about it. Yeah. Mm-hmm. Bill Gasiamis (06:39)seems to be doing okay, but the caregiver is struggling and doesn’t ask for help and doesn’t go and doesn’t go and get looked after. And then things tend to catch up with them and they become the ⁓ sickest person in that relationship. Jack Clifford (06:55)It’s like that whole put your oxygen mask on first on the airplane type thing, right? Like, you know, we can’t we can’t give what we don’t have to give Bill Gasiamis (07:01)Uh-huh. Yeah. So you, did you notice, did you notice the steady decline in your health? Did you kind of go, I’m not feeling right. I’m a feel a bit sluggish like 10 years down the track, or did it just creep up on you? then you got to this point. Jack Clifford (07:15)It really crept, it really crept. I, you know, like I had initially exercise induced angina, but it wasn’t much exercise that induced the angina. And then it very quickly progressed to trying to walk and getting out of breath and, know, at very basic walking speeds, just moderately paced, you know, anything anybody would do out in your neighborhood. ⁓ Bill Gasiamis (07:39)Did you know that you had an angina? Jack Clifford (07:41)I did, yeah. I didn’t have a big heart attack episode like some people have. I’m 100 % blocked. There’s no heart attack to happen, right? Because the stuff is, I’m so blocked that it’s just a pure blood flow issue. A lot of people don’t understand that that 50 % blockage is a huge risk for a heart attack because you’re gonna burst a plaque and then go from 50 % to 100 % like that. But you know about collaterals. And if you have collaterals in place, the blood’s not getting flowing this way, you’re gonna recruit some lead oval collaterals to be able to just get by with your activities of day living. But if you don’t push yourself, you don’t know that you don’t have enough blood flow to do these other things. Bill Gasiamis (08:22)Okay, so you got to the point where you were so unwell as far as the blood vessels around your heart were so unwell, they were so blocked that angina led to another escalation or something happened that got you to the point where you realized, okay, things are not good. Now, tell me what angina is exactly and what it’s like to have it. How do you experience it? Jack Clifford (08:39)Yeah. yeah, yeah. I’d love to talk about that. Bill. at its most basic, it’s a supply demand mismatch. So, you know, the blood flow that’s supplying your heart ⁓ is adequate for X, Y, or Z activities of daily living. You know, walking around the house, doing the dishes, you might have enough blood flow for that, but you don’t have enough blood flow to go run a mile or even walk potentially, you know, or Hospital Experience and Heart Health but it’s all about supply demand mismatch. And that’s about just the size of the pipes, you know, if they’re clogged up, how clogged up are they? And, know, ⁓ that’s, really it. So, and what it feels like is it’s scary because it feels like a heart attack. all like, what does a heart attack feel like? Well, there’s a thousand different sort of, ⁓ descriptions of it. ⁓ you know, radiating down your arm or nausea or something in your back, but. you know, if it’s right over your heart, it’s unmistakable. And that’s at least my presentation of angina. And I think it was a pretty typical one is, you know, I have this weird kind of deep pain. initially, when I, when I started, you know, run, trying to run and got it, I thought, ⁓ you know, I just pulled a chest muscle weirdly over my heart. You know, I’ll stop and let’s see if it goes away. I come back, you know, no, same thing. Okay. Still not better. Let’s do it again. Another couple of days later, so on and so forth. I was just kidding myself, but I didn’t know anything about the horror at that point. hadn’t had to research all this stuff and do all the deep dive. Bill Gasiamis (10:16)That’s the same crazy logic that stroke survivors put to, I’m feeling weird. I’m dizzy. I’m going to go and lie down. I’m going to rest. It’ll be better later. ⁓ I’m too busy. I’ve got to go to work. ⁓ I’ve even had stroke survivors where somebody’s telling them you maybe you’re having a stroke, you know, just tongue in cheek and they’re like, yeah, no, probably not. ⁓ it’s the same crazy logic that we say about things that are unfamiliar to us that we cannot potentially. Jack Clifford (10:25)Mm-hmm. Mm-hmm. Yeah. Yeah. Bill Gasiamis (10:46)link to something so serious because we have no knowledge, we’re ignorant, right? Jack Clifford (10:47)Yeah. Well, yeah, I think that’s really part of the key there is like most times with something as sudden as what you’re talking about or what I’m talking about in my instance, because it was pretty, pretty sudden, you know, weeks and months. ⁓ We went from being these, you know, healthy people that felt like we were on top of the world to all of a sudden not. you you didn’t have a frame for what not looked like. ⁓ Bill Gasiamis (11:14)Exactly. Yeah. That’s such an important comment. We don’t have the frame for what not healthy looks like and therefore you don’t know what you don’t know. So you don’t take any action. You just brush it off. Okay. I hear you. All right. We got to the bottom of the stupidity behind a lot of my decisions as well to avoid going to hospital for a week, et cetera, the first time. ⁓ So you end up Jack Clifford (11:24)Exactly. That’s it. Bill Gasiamis (11:43)being really unwell on this particular date. Kind of what is that day like? Explain us. Jack Clifford (11:46)Yeah. Yeah. Decisions Against Medical Advice So I got tight. I, I, I’ve been a biohacker for a while. So that’s probably the only reason I’m here talking to you because I went off the beaten path really far off the beaten path to get to the place where I know what I know and I have to share what I have to share. ⁓ because I’ve been trying to help my wife get better for some significant issues, including a really bad traumatic brain injury. And some other things and doctors didn’t have the answers for those so we had to we had to kind of biohack our way out of some things I was comfortable back. I’m saying that to say my wife got me a Chili pad for my bed because you know been trying to biohack sleep for a while and the colder environments to sleep are you know better to some degree at least in theory ⁓ and so Yeah, correct Bill Gasiamis (12:32)Chili meaning cold, not spicy. Jack Clifford (12:37)Yeah, correct. A chili pad as in the cold. So it’s a device that just, you know, cools your bed off. And so I crank that down to 55. She got it for me for Christmas. So Christmas day Eve, I’m like hopping into bed, like I’m going to sleep really well tonight, you know, and I woke up at four AM like, Oh, you know, I thought that was the big one because it felt that way. I a dead sleep woke me up with, with intense chest pain. And I knew something was going on, you but I was kidding myself. I hadn’t talked to family about it. You know, I hadn’t shared anything about what was going on with anybody. So at this point I’m like, oh my goodness, you know, and I could be dying and have not had, you know, just been an idiot the whole time. So I rushed to the hospital and I didn’t have a heart attack. I just made it so cold that I made my heart work and that supply demand mismatch was happening all night long in my sleep. Bill Gasiamis (13:15)Mm-hmm. Jack Clifford (13:31)And so it got to this, you know, a giant, creeps up, you know, it’s like, can feel it. And then if you push it, you’re like, can really feel it. Well, you know, I woke up out of a dead sleep going from not feeling it when I went to sleep to, to feeling it to the extreme when I woke up. Um, but that’s when they gave me the, uh, the, uh, nuclear stress test with a treadmill test, right in the hospital. And it was, it was really bad. They can’t quantify your blockages with that, but they can tell you that, you know, you’re You’re kind of screwed. And I was like really screwed. Like it was 47, but they said I was one of the worst I’d ever seen. ⁓ yeah. So I had all weekend to think about it, you know, cause I was a Friday, fortunately, and they could, they weren’t going to do the heart catheterization until Monday and the doc, you know, I was signing consent forms for them to do bypass surgery and it was pretty clear that the odds of it getting stented was not really good, but that’s what you hope for. Right. And most people are like, we’ll just get a step. once then in you’re fine. And ⁓ in my case, it wasn’t looking likely. And my mother had had bypass surgery five years before that. And I watched her cognition after the bypass surgery just declined to the point where she’s in memory care now. And she had gone from being this vibrant book author of multiple books and you know, she was a hypnotherapist and she’s helped a lot of people in her life, done a lot of amazing things, but ⁓ she never. she never really came out of the bypass surgery as her whole self and pretty quickly was just completely not herself at all. ⁓ So I wasn’t ready to come back. Now she’s 76. Bill Gasiamis (15:03)How old? How old’s your mom? Yeah. I know with people that are older, ⁓ heart surgery can lead to cognitive decline and there is a link there. There is a number of it’s well researched. It’s a risk. ⁓ not one that you’re probably aware of and that they talk about much, but it definitely is a thing. so, okay. You’re, you’re you go to the hospital. They realize, ⁓ the Jack Clifford (15:15)Mm-hmm. Bill Gasiamis (15:37)charts are not looking good. ⁓ They do the tests. They suggest that what they can offer you is bypass surgery. your, and you’ve got a weekend, think about it and you, and you go home, do they go, do you go home with medication and joining the medications to keep the blood flowing with anything? What do they do? Jack Clifford (15:51)Mm-hmm. Where’d you go? Yeah, such a blessing. No, no, because I was leaving against medical advice so they weren’t going to help me, right? And I actually said to the doc, said, you hey, I’m new here because I just moved a couple of months ago to Florida. And I said, can I come see you? And I didn’t have a cardiologist. I didn’t need one before this. And he says, if you live that long, just walks out. So I was on my own at that point. There was no resources of institutional medicine. I had to go find resources myself. Exploring Alternative Treatments Bill Gasiamis (16:28)Wow. Things are pretty wild in Florida. If you live that long and he walked out. Jack Clifford (16:30)Yeah. Yep. That’s exactly what we said. It’s a very sobering moment for me. Yeah. Bill Gasiamis (16:35)And you walked out. Yeah, and you walked out. Far out, man. So what’s the thinking behind walking out of that? Because I understand ⁓ that there are very few things that, like my situation was different, right? But I’ll give you kind of my thinking behind the, I’m gonna walk out routine. It’s like, there is a part of me that sort of says, I don’t need to subscribe to all that medical stuff, all the nonsense. I wanna try and avoid the medications. I wanna do all of that. Jack Clifford (16:41)Yeah. Yeah. Bill Gasiamis (17:07)That means I’ve got to do some work to get to that point, right? I’ve got to make sure that I’m eating well. I’m sleeping well. ⁓ I’m exercising. ⁓ I’m not overweight. I’m not smoking. I’m not drinking. Like there’s a responsibility that goes with, don’t want to take that medication. Right. And one of the other things is that, ⁓ if it wasn’t for the medical industry, I would not be here recording this, ⁓ podcast. Yeah. So there’s this big thing, which is. Jack Clifford (17:31)Yeah. Double-head sword, right? Yeah. Yeah. Bill Gasiamis (17:37)They’re not fixed. My brain is not getting fixed unless they go in and take out the faulty blood vessel and potentially risk all the complications that, that I got the ones I got, but also the ones I didn’t get, which many people get, which is far worse deficits than what I visible on me. So, ⁓ I’m, you know, I’ve never met anyone in my time who hasn’t Understanding Enhanced External Counter Pulsation (EECP) who has been through the medical ⁓ system, who hasn’t benefited from it in a way that’s sort of sustained their life, supported their life, lengthened their life. Like everyone that I’ve interviewed has always gone through the medical system and has saved them, supported them, helped them, right? And you’re going to, the first place to get help you’re going to is a hospital, right? You ring up and you go, I’ve got to go. Jack Clifford (18:22)Yeah. Bill Gasiamis (18:31)to the hospital because I’m feeling like I’m having heart attack. You get there, they confirm it, and then the place that you go to for help is the place you walk out of. What’s the thinking? Yeah, yeah. You have the angina, the blockages. Yeah, you got all of that. Jack Clifford (18:41)Well, I didn’t have a heart attack. That’s a really important nuance point. you know, I’m sitting in the hospital all weekend. there was nothing at risk in an emergent moment for me. My heart wasn’t, you know, I wasn’t going to lose heart muscle if they didn’t do something. Like my mother’s instance was different. She had a heart attack. She probably needed the bypass surgery. It was really hard on her, obviously, like we talked about, but in my case, I had time, but they didn’t treat it like I had time, right? Bill Gasiamis (18:54)Okay. Okay. Jack Clifford (19:10)They treated it like, we’re gonna go in and take care of this thing for you rather than you have time to explore other options when I knew in fact I did. So it might be that getting bypass surgery is the right move for some folks, but it also might be the right move for you and me. We’ve already discussed that you take care of yourself so you never get in that situation. And yeah. Bill Gasiamis (19:32)Yeah. And this is not a interview about do as I say, this is not that interview, right? What this interview is like one person’s experience and what they did. That’s it. We’re not giving medical advice here. We’re not telling you what decisions to make. We’re not telling you any of that stuff. This has got nothing to do with advising anyone to do anything, but what it has got to do with is what either you discovered Jack Clifford (19:45)Yeah. Right. Bill Gasiamis (19:58)or you knew before and put into action or what you discovered after you left the hospital that weekend. So take us through the next sort of phase of I’m taking responsibility for this and I’m going to take advantage of something that is documented scientifically and proven. Jack Clifford (20:03)Yeah. Okay. Yeah. Mm hmm. Yeah. Yep. Yeah. And you know, like, so I’ll go into that phase, but, but I just want to share this thing because, know, you, you pretty much already told me when you first heard EECP, you like EECP what? Right. And most doctors are EECP what? Basically every patient is EECP what? And it’s, it’s just, it’s really not going to lie. really bothers me because this, this, this therapy is, is so well-documented. It’s, it’s, it’s FDA approved. It’s not controversial. Bill Gasiamis (20:25)Mm-hmm. Jack Clifford (20:43)⁓ it just anyways, okay. So, so, so yeah, so I leave the hospital and the only reason I knew about a EECP was because when my mom had her heart attack, I listened to a podcast by Ben Greenfield. He’s a pretty, you know, pretty high-level guy, right? And that had been, that was like 2015. And I just heard mention of it. was like, it was maybe like two minutes of the, of a 60-minute podcast at most, but I was like noted. So I looked into it from my mom. The closest provider was two hours away and you got to go 35 times and my mom isn’t going to drive. 35 times, you four hours round trip. It wasn’t gonna happen, so we moved on, but I just sort of knew about it. And when I say knew about it, I didn’t know, Bill, like what it actually did or how it worked. I didn’t look into it at that level. just, you know, like assessed the situation. I was like, okay, there’s something out there. That’s it. Okay, yeah. It stands for enhanced external counter pulsation. And you want me to go into a little bit about how it works? Yeah, okay, so. Bill Gasiamis (21:27)Hmm. And what is a ⁓ CP stamp? What does it stand for? Yeah, yeah, let’s do that, yeah. Jack Clifford (21:42)So EECP involves lying on a bed. From the patient experience, you’re lying on a bed. You have ⁓ cuffs wrapped around your calves, your thighs, and your hips. And inside those cuffs, there are little air bladders. Bill Gasiamis (21:55)those cuffs, are they like blood pressure cuffs? The Mechanism of EECP Jack Clifford (21:58)Yeah, like big giant Velcro blood pressure cuffs. Yes. Bill Gasiamis (22:02)Okay, so like they’re much bigger than a regular cuff, which is just over the bicep. Okay. All right. Jack Clifford (22:04)Yes. Yes. Correct. yeah, just that’s the right way to think about it. you you cinch them up, you’re getting really snug in this thing, but it looks like a giant pantsuit, you know? ⁓ And you lie on the bed and then you get a three lead EKG on you. It’s here, here, in here. And then in between heartbeats, the machine… inflates compressed air into those bladders at 1.3 psi to start with, which feels like kind of a gentle massage. And then the pressure can be increased in increments of 0.1 psi all the way up to six, which feels like the exact opposite of a gentle massage. However, if you go slowly, your body accommodates to that pressure and that pressure feels different, both over one session and over multiple sessions, meaning you might not get to six your first session, that’s unlikely, but as you do repeated sessions, you’ll increasingly get closer to six earlier in the treatment and be cumulatively more hours at those higher pressures. And what’s happening is all the blood, not all the blood, a significant amount of blood from your lower body is being pushed up in between heartbeats and it’s causing this phenomenon called sheer stress in your vascular systemically. And wherever there’s pressure differentials in the body, it’s giving a stimulus to grow. It’s saying the pipes are not big enough, you gotta grow. We’re trying to put through more than is gonna fit. The body’s like, wait a second, it’s not big enough. But growing things in the body takes time. And so you need those repeated sessions. Like I mentioned, T.R., before we started recording, it works just like cardiovascular exercise, but at levels humans can’t do on their own. ⁓ And so, yeah. Bill Gasiamis (23:52)That’s important to talk about. so just for a moment, we’ll talk about that. Like it works like cardiovascular exercise. So the idea with cardiovascular exercise is that what, does cardiovascular exercise do that’s similar to EECP? Jack Clifford (24:04)Sure. If you’re out running, when you hit that stride on your feet, you’re doing that same thing, right? You’re ⁓ sending blood up, right? And then your circulation, your heart’s beating twice as fast maybe than it normally is, or substantially more than you’re just sitting here heartbeat is. And that’s because the heart is responding to the environment around it and saying, I gotta get… a lot more blood, a lot more places. So I gotta work a lot harder. you know, is maintenance. So collateral blood flow. have alternate routes that we can use that lie dormant throughout our body. And those collaterals, if they never get used, they honestly, they get weaker and they close off, but they also can be reopened, you know? And then you can grow more of them. And… Bill Gasiamis (24:38)And what’s the result of that? Uh-huh. Okay, so there’s blood vessels that get less ⁓ blood flow because people are sedentary or people aren’t doing the type of exercise that would activate those blood vessels, for example. And then what in theory, not in theory, and then what happens in cardiovascular exercise, the body goes, we need more blood flow, let’s open up. Jack Clifford (25:12)Exactly. Bill Gasiamis (25:26)other areas where normally blood flow wouldn’t be required or doesn’t go. And EECP kind of mimics that mechanism. Jack Clifford (25:27)Yeah. Exactly. Yeah, but not kind of, it’s really important just to note, cause I don’t want, I don’t want any of your listeners thinking, well I’m just going to go run more. Right? I mean, by all means do that safely. You know, the dose always makes the poison with everything, but, but don’t think that you can, you can just go do this. You can do it to a limited degree with exercise, but you’re not going to grow, you know. that I didn’t have that before. And I like it because it shows you like the world of the possibly or it might be a little unsightly, but it’s feeding my brain. EECP has changed my cognition in addition to my heart, you know, my pelvis and my kidneys and my liver. you know, like it’s, it’s optimized blood flow systemically. Um, yeah. Yeah. Bill Gasiamis (26:19)Okay, so let’s go back to the cuff, the cuff that we put on and then what happens. Jack Clifford (26:24)Yeah. Yeah. So, so you just lie on the machine. Typically you do 35 hours on a machine for a course of treatment and one hour a day is a typical, you know, five days a week. That’s just typically you’re going to the doctor. There’s lots of other variations of that, but that’s the typical course. And that’s the most well-researched course. And, ⁓ you know, over time, usually about halfway through those 35 sessions, if you had angina, you’re going to notice a difference, but Personal Transformation Through EECP you know, they use this to treat dementia. It’s a well studied in dementia. There’s a recent study in the US that was profound, a year-long study, a hundred demented patients, roughly a hundred non-demented or a hundred treated patients. Everybody had dementia and a hundred CHAM patients, placebo. The demented patients that got an EECP, they all got better when we know dementia, people get worse in a year, right? They all got better, all of them. And yeah, so that’s like, you know, similar phenomenon erectile dysfunction, similar phenomenon kidney disease, similar phenomenon stroke recovery. So, you know, these are studies. I’m not making it up. It’s just literally like really well documented. It’s not. Bill Gasiamis (27:33)studies that we can get a hold of and put in the show notes, link to the show notes. Jack Clifford (27:36)Yeah, go to to EECPLocator.com and all these studies are there. ⁓ Yeah. So what I did is in the U.S., I, you know, it’s really hard to find. so I couldn’t find it. I had to, I had to call around and like, I could find a few doctors, none of them near me, but a few of them that would had machines, but they would only use them after everyone had failed stints and failed bypass and they had nothing else to offer them, which makes no sense. But that’s how the insurance reimbursements work. Bill Gasiamis (27:41)Okay. Jack Clifford (28:04)That’s the only time they’ll actually pay for it. So that’s what they say it’s good for, but that’s not what it’s good for. That’s just what they can get money for, I guess. but, so I had to drive three hours and take a chance on a doctor and stay in a hotel to get my treatments. And it was really difficult. I mean, I ended up buying one of these machines and got it at my house and I’ve just been using it for the last five years. So, you know, 35 hours was great, but I was pretty bad off. Now I got about 700 hours and, uh, you know, more hours is just greater stimulus to the body to grow vasculature, right? And I mean, I… Bill Gasiamis (28:38)how do you know that you’ve grown? I know there’s this ⁓ feeling or this change that happens in the person. ⁓ Like you said, dementia, ⁓ people who experienced dementia have a better outcome later or a change in the way that they’re brain working, et cetera. can you see the, is there a way to see the difference between the blood vessels and Jack Clifford (29:02)You can’t, you can’t image, could image on a, on a cardiac pet would be like the only imaging or I guess, you know, if I went back and did a stress test again, you would, you would be able to see, cause it’s not quantifying specific arteries. It’s, quantifying the total volume, but I tried that they were, actually wouldn’t let me, they said it’s not safe because you have it at a stent or a bypass. So I went back to the same place that I got it, you know, and I was like, literally they put me through the imaging machine. gave me the dye and then they got Lifestyle Changes and Holistic Health I went to go on the stress test and the same doctor was there and he refused to tell me to go. So I like, wanted to say, hey doc, let’s go for a run. Cause like, you’re not going to keep up with me, but you know, so I, I didn’t bother with that, but I’ve got my own, you know, I did my own little stress, stress test with a treadmill, right? I started, I was getting chest pain. I found out where I can induce angina and I try and say just below it, you know, so I know where it is, right? I was 2.2 miles an hour. That’s not a fast walk. And then after the first 19 sessions where I was staying in the hotel, I got up to 2.7. That’s a really big difference even if it doesn’t sound like a lot. And then I got my machine and I kept going. And then within a couple of months, I was starting to do a running stride. And I could keep that up, no angina. I know where angina would come in. I had time calculations and everything. And then eventually, now I can run. comfortably 6.5 mile an hour pace for quite a while, know, push it up to 14 miles an hour for 30 second sprints and you know, like all kinds of stuff. So, ⁓ Bill Gasiamis (30:38)How long before you break the two hour barrier for the marathon? Like was recently done. Maybe, maybe the more blood vessels, the more blood flow. Maybe you can get there. Jack Clifford (30:42)⁓ I got zero interest in that. Yeah. I think so though, I think those Kenyans should be ⁓ hopping on these EECP machines and they’re I mean, they’re already amazing but. Bill Gasiamis (30:58)Well, you want the Kenyans to just completely own marathon running for the rest of eternity. It’s unbelievable what they did. Right. Like I imagine that there is something else going on there, but I imagine blood flow, oxygenation, more blood vessels. Like it’s got to potentially be a thing. reckon if you do a check between the last guy, me, who’s going to like 50 hours before you get to the other side and those dudes, there would Jack Clifford (31:03)Yeah, yeah, it’ll just be a Kenyan Yeah. ⁓ Bill Gasiamis (31:27)definitely be a difference because they’re exercising all the time, right? Jack Clifford (31:31)Sure, yeah, they’re pushing the collaterals as wide open as, know, whatever, whatever a human can do on their own, they’re doing it to the max to, know, the same phenomenon that EECP is doing for folks lying down. You know, they’re doing it to whatever the max you can without the machine, I would say. Bill Gasiamis (31:48)So this is a bog standard human body task. Like it just does that all the time. I have heard the blood vessels can reroute in the brain when somebody experiences a blockage and then, and it’s not useful at the time of the blockage, obviously, and it causes potential cell death when somebody has a stroke. But then later on. Jack Clifford (32:11)If there’s too much blood, the revascularization, yeah. Bill Gasiamis (32:14)Yeah, so EECP can kind of occur naturally and then it can support as much of the surrounding tissue as possible so that it doesn’t all die off. ⁓ So what you’re talking about is just encouraging EECP ⁓ to happen more than it would normally happen by ⁓ inducing it through this device where people ⁓ get sort of strapped in and then Jack Clifford (32:23)Yeah. Bill Gasiamis (32:43)the machine runs, what does it run like a program? Explain how that works. Jack Clifford (32:47)Literally, it’s just air pressure. got different pumps to pump the calves, the thighs and the hips up. And then it’s really just about the timing, right? It’s got to hit it at the right interval of your heartbeat. So it’s at the right place in diastole where your heart is at rest. that timing is very, crucial. And that’s really… Yeah, it’s not, it’s very old technology. The machine I have was built in 2009. You know, they have new machines that are portable now that I’m working with some of the manufacturers to actually, you know, make these available in the U S because there aren’t any in the U S but they do have portable machines that don’t require a bed. You could get treated on your couch. You could get treated, you know, on your own bed, uh, lying on the floor, I suppose. Um, so, you know, we’ve, we’ve really like technology hasn’t Bill Gasiamis (33:19)Wow. Jack Clifford (33:42)slowed down. just China’s like taking this thing and you know, have a basically every Chinese hospital has several of these machines and they treat patients in the, in the room with us. It’s, part of their standard of care for all kinds of different, different diseases that they’re treating. You know, and it’s adjunctive to just about everything. There’s nothing that you couldn’t do EECP with, right? ⁓ yeah. Bill Gasiamis (34:03)Okay, okay, so. How do you experience your body differently now? And actually, let’s go back actually, how long has it been since you came across this, decided to get the first treatment, implemented yourself ⁓ at home and then how do you feel different now? Jack Clifford (34:08)Oof. Yeah, it’s been five years and four months now. And every since like, this is this is a little hard part to quantify, because there’s been a lot of brain changes to from this, right? So so I don’t even like feel like my 47 year old self who was in the hospital, that feels really like somebody else to me. You know, it’s a version of me, I suppose, but I can’t really relate to that person. Because I like a small example. The Impact of Stress on Health I used to sleep eight to nine hours a night. That was my normal, my whole life. I was generally like the guy that would come in the latest. You could come to work. was the guy that came in the latest. You And now I get up at two 30 most mornings and I’m like, like rare to go with energy. I’m, you know, I’m working out doing resistance training. I’m reading, you know, I wrote a book, I’m writing another book. I’m writing a book on rectal dysfunction as it relates to this phenomenon, because that’s a whole other, you know, case study. and I work a full-time job and I just have an incredible amount of energy basically all the time. My mood is way better. My sense of touch is really different now. I give a lot more hugs because it feels really good. ⁓ My sense of smell and taste and… You know, hearing, you know, I used to like have to go to the bathroom at night sometimes, you know, wake me up to go to the bathroom. Long gone. Bill Gasiamis (35:47)So at the same time though, it sounds like also you might have changed other things as well though, right? So what else have you changed in the meantime? Jack Clifford (35:55)sure. Yeah. Yeah. Yeah. It hasn’t just been EECP. Absolutely. you know, really good supplement routine. ⁓ Pretty extensive, but, you know, managing my lipids, for example, I take a thousand milligrams of niacin twice a day. I’ve been able to bring my triglyceride to HDL ratio to kind of an optimal one-to-one, using fish oil and some other things. ⁓ And, you know, I… I really stay away from carbs for the most part. I like to eat keto, but I like it to be what I call clean keto. So I’m not like pounding keto ice cream or all these things that are, you know, they taste good and yeah, they’re keto, but they got all kinds of oils in them that aren’t really good for your body. ⁓ And, ⁓ you know, I’m big into moving and being active and, you know, having an engaged social life as much as possible as well. I mean, I think that’s a very underrated thing. That’s actually an area I struggle in because I’m working so much, but you even this helps just, you know, getting to know people even online. But, ⁓ Bill Gasiamis (37:04)It sounds like you haven’t re it doesn’t sound like you’ve reinvented the wheel. Like everything that you say is things that people take for granted that if they implemented would improve their life before EECP. We’re talking about EECP today, right? But just those things alone would make a massive difference to somebody’s experience. And that’s kind of the message that I’m trying to kind of get into the Jack Clifford (37:17)Totally agree. I thought it a good Sure. Bill Gasiamis (37:30)⁓ minds and hearts of the stroke survivors who I interview and who listened to the podcast. My book, I’m going to, we’re going to talk about your book in a sec, but I’m going to talk about my book. My book, when I wrote it, I thought I discovered all these things that people, should know about that no one knows about, but it’s not true in here is mindset. ⁓ there’s a chapter about emotional intelligence. There’s a chapter about nutrition. There’s a chapter about sleep. There’s a chapter about community. Jack Clifford (37:32)Yeah. Yeah. No, please. Bill Gasiamis (38:00)⁓ that’s just the five that I can just rattle off the top of my head right now. And you’ve already mentioned that in the last few minutes, that’s exactly the things that you mentioned. And people take it for granted how much that improves your overall health. Right. The Journey of Writing a Book Jack Clifford (38:13)That’s so true. And also what’s wrapped up in the wrapper of all of those things that are threaded together is stress, right? ⁓ If you do all of those things, right, you’re lowering stress. How did I get heart disease at 47 when it happened to my grandfather in his late 60s and my mom in her mid 60s and it happened to me at 47? And we know it didn’t happen at 47. It was years earlier and I realized it at 47. Stress, you know? Like I was the guy that took on a lot. Bill Gasiamis (38:38)Hiding earlier. Jack Clifford (38:44)and had some traumatic things happen in my life and whatever, and I don’t need to go into that. But I always felt like it was all rolling off my back. Like, you know, I’m fine. know, like I didn’t, and there are reasons why I felt that way. ⁓ However, at the end of the day, I know that I wasn’t processing. There was so much I did not process. And I didn’t learn how to like have really good boundaries and that, you know, begot more stress because of those lack of boundaries and, but stress, right? You know, like, but if you have good good social life and healthy people in your lives, that takes stress off. Eating the right food takes oxidative stress off your body. You could go on and on, but I think stress is gonna kill you before anything else. Bill Gasiamis (39:17)you Yeah. I love that you said that. I love what I love that. That was the answer that you gave when I said, what else did you do? Because it’s not just, you know, it’s like, I’m going to eat well, but smoke, you know, I’m going to eat well, but drink excessive amounts of alcohol. Like, no, it doesn’t work. You know, you can’t do that. Yeah. can’t do. Yeah. Small. Jack Clifford (39:42)No, you gotta do it all in concert. It’s the layers, right? Yeah. Bill Gasiamis (39:49)numbers, know, the percentages they add up, you know, 1 % here, 1 % there all adds up and you get a result at the end of it. Okay. So, so you’re you’ve gone, I’m going to see if I can grow new blood vessels to support my heart. And what you’re found between the time that you went to hospital around five years ago to now is that the angina has Jack Clifford (39:55)Yeah. Mm-hmm. Bill Gasiamis (40:17)⁓ improved, they’ve gone away. The heart has improved, I beg your pardon, the blood flow. And have you had a medical examination since then to do other comparison? Jack Clifford (40:28)Yeah, I have. Yeah, I’ve got a cardiologist. I haven’t seen him and I’ve talked to him the other day because I talked about the book, but I haven’t gone to see him because he’s a plane flight away. But I’ve been worked up for the crowded intermediate thickness. You might be familiar with that as it relates to stroke. okay, well, they just measure your crowded arteries and look at the placking in your crowded arteries as a proxy for your systemic plaque burden. And flow mediated deletation, is they totally occlude the… the arm with a blood pressure cuff and then see how quickly you can refill it after, you know, like, it’s like five minutes of this, your hand is completely numb. And those all, you know, workups were good and that was after a couple of years of treatment. You know, I tried to have that stress test, like I mentioned, but you know, now I just see my primary care, you know, he’s a good guy and he runs on my lipid panels and, ⁓ you know, so I’m definitely monitored, but. What I haven’t done is gotten re-imaged because I don’t want to put extra dye in my system. Sure, somebody wants the images because they don’t believe me, but I’m not trying to sell anybody anything here. I’m just trying to spread the word on something. If somebody doubts my honesty, they can, it’s fine. Bill Gasiamis (41:38)I know what you mean, Jack. I know what you mean. I and I asked you because yeah, I would love to see that before and after. would love to see the blood flow. What’s happening, watch change. would be amazing. story to tell, but I also went out of my way if I could to avoid having more dyes and all that kind of stuff injected into my body. I totally get it. It’s okay. Yeah. ⁓ Jack Clifford (41:49)Yeah. Yeah. Yeah. Bill Gasiamis (42:01)Okay. So you wrote a book about it. Like, what was the idea behind the book? What were you thinking? Show us the one that you got there with the old book cover. And then I’ll include the new book cover in this image as we chat. Jack Clifford (42:06)yeah. Yeah. Yeah. Yeah. Thanks. Yeah. So I started writing this book, in, know, ⁓ November timeframe, ⁓ after I mentioned to you, so my, my friend came down, ⁓ and stayed with me for 13 days and he had had some stroke damage five years before that was, you know, his whole right side, he just had like numbness and then pain. And then, you know, it this weird cascade of symptoms so bad, you know, sometimes he couldn’t sleep from it. And so All the time he took off work he could he came and he used the machine three times a day and then he left pain free and like nothing else had worked and then this worked and I didn’t per se expect that I but I was like, you I know it does stuff. It’s helpful. But anyways, when I saw that, you know, I really started digging even more because before that I was like, well, Jesus is amazing. But maybe it’s just me, you know, and and anyways, so, ⁓ so then I, you know, I just started writing the book one day and The Role of EECP in Heart Health You know, my mom was a book author and I always wanted to write a book. didn’t really have anything particular to write about and all of sudden I do. So I’m like, you know, let’s see what happens. And, uh, and you dig into the research more and more, and you’re just like, increasingly frustrated by how everyone has known about this. And yet, you know, they don’t promote it. They don’t talk about it because it’s inconvenient. You know, and I’m going to get a little, try not to get like soapboxy here, but Bill Gasiamis (43:36)Do it, do it, go for it man. Jack Clifford (43:37)Okay, okay, because, you know, cardiologists will say it, some of them, the ones that are honest, they’ll be like, like mine. He says, I was making obscene amounts of money, giving people bypass surgeries instance. And then I was given the same people bypass surgeries instance, a couple years later. And, you know, and then he stumbled upon some answers and EECP is one of them that helps his patients stay well. And, you know, he makes a lot less money. because of it, because he doesn’t go in and do these interventional approaches. And, you know, EECP, the most you could pay somebody is like $100 an hour, and you’re going to tie up a patient room for 35 hours with a tech, it doesn’t make any sense. I go pop a stint and you make 10 grand in two hours and never see you again. You know, like it just, I get it from, you know, I want to own a portion of Ferrari and have a lake house and a winter house, but You know, like, I don’t know how you live with yourself. You said go for it, man. I’m going to go for it. you know, and my son’s about to graduate. Okay. Yeah. Okay. Fair enough. I’m good with it. Yeah. Yeah. Bill Gasiamis (44:38)But come on, come on, Jack. Yeah, you go for it. I’m going to push back. I’m going to push back as well. You go for it. I’ll push back. There’s yeah. Which is cool. Right? That’s what I want. I want to have a conversation and I don’t want to control the narrative, but the guy that goes in needs a stint today has a blockage. Like that’s life saving. That does work. What I am afraid of that happens sometimes when people go in and they’ve got a blockage and then they get ⁓ even even a stroke blockage. Right. in carotid or a vertebral artery. What happens is sometimes people go in and they get told you need a stent. Fair enough. You’re about to have a heart attack. You’re about to have a major stroke. If we don’t put one in, you’ll have a, that’s necessary. The challenge is, that that person sometimes doesn’t learn the lesson of what got them into the situation where they need a stent. Jack Clifford (45:22)Good. Exactly. sure. Yeah, by all means. Like emergency medicine is great. And we’ll put that in the emergency medicine category of cardiology, right? Why aren’t they offering you, why aren’t they saying, Hey, you’re at risk for a whole lot of other things just by this happening. Why don’t you come 35 times to this EECP machine and you know, like, or why don’t we have centers Bill Gasiamis (45:36)Yeah. Yes, and then later… Jack Clifford (45:55)all over. I found exactly one place in Australia so far that I’m not focusing on Australia right now. I do plan to take EECP Locator International, but right now the access points in the US are abysmal. 70, 80 % of the people in the United States could not get to a center. There’s no access point that’s at all realistic for them to get to. And yet these machines are not that expensive. They’re the price of a Decent not that great car. ⁓ Bill Gasiamis (46:24)we’re starting to see them in, I don’t know, health spas or something like that, where people will go, they’ll get yoga, they’ll get this, they’ll get that, they’ll get infusions perhaps and all sorts of other things. And there’ll be a machine or there’ll be a suit that people can put on and they can go through one hour. Jack Clifford (46:29)Yeah, that’s good. That’s great. Yeah, although I do want to say that the Normatech, like the compression boots that they have and some of those things, when they don’t use the pressures that EECP uses up to 6 PSI and they’re not sinking it in between heartbeats, it’s helpful, but we’re not talking about things that can do the same thing in the body. It’s on the right path and I’m not digging it as being worthless because it’s not, but it’s just not the right thing. Bill Gasiamis (46:47)Yes. Yeah. Yeah. Yeah, that’s kind of what we’re seeing. And to go back to your point is because the medical profession does medical profession stuff. this is not, it’s not that it’s not medically kind of aligned. It definitely is. But when you’re told that the way you solve a problem is through putting a stent in and then never talking to that patient again, to tell them how to avoid to get a stent in that’s Jack Clifford (47:31)Yeah, that’s your job. Bill Gasiamis (47:34)what they do, like they’ve been trained to do that forever. And that’s what they do. And that works and it saves the life. But what it doesn’t do, which I also have a challenge with this, it doesn’t teach the lesson. What it reinforces is that if I have something wrong with me and I go to a doctor, they’ll fix it. So next time it goes wrong, I’ll just go to the doctor and they’ll fix it again. And I didn’t have to change my life. Like this even bloody advertisements that do that. They Jack Clifford (47:51)just I’ll go and he’ll fix it. Yeah. Yes. Yes. Bill Gasiamis (48:03)They hijack that part of the person’s brain and they say, you know, have you got reflux, heartburn, that kind of stuff? Don’t let reflux and heartburn get in the way of eating the foods that you love. Just take a tablet. You know, that’s the same kind of thing, right? And that’s why the medical profession doesn’t do that because they’re not trained to do anything other than sell their thing. And their thing is what they went to work, to school for. Raising Awareness for EECP Therapy Jack Clifford (48:17)Yes. Bill Gasiamis (48:30)20 years to be able to administer. But every so often you come across an amazing doctor, surgeon, et cetera, who says, I can’t do anything more for you, but maybe somebody else can. Those guys are better than the doctor who says, we can’t do anything else for you and then send you off their way. That next sentence, but maybe somebody else can, I don’t know who they are. That is. Jack Clifford (48:43)Mm-hmm. Bill Gasiamis (48:57)I think a great thing to say this is where I think EACP kind of fits in that now that I’m here and things are not good. Jack Clifford (49:05)I totally agree. I totally agree. And yeah. And you, so you, you mentioned like the wellness spas and whatnot. And here’s the thing in 2015. So, you know, somewhat recently the FDA approved EECP for a brand new indication, general circulation, right? In healthy people. Like it’s right on the FDA indication. And also in one case in increase in VO2 max, but rough, that’s roughly saying the same thing. ⁓ yeah. Bill Gasiamis (49:32)for healthy people, was that part of it? Jack Clifford (49:35)Yeah, it said unhealthy patients and healthy people didn’t call patients. So, so, ⁓ but, but, know, the litmus test for that is, is your doctor say you’re healthy enough to undergo circulation enhancement? If the answer is yes, you know, it doesn’t matter if you got all that other stuff or not, you know, we’re just not treating you for it. We’re not saying ECPs is fix for this, your erectile dysfunction. It might help it. You know, what’s not saying it’s, it’s the fix for your stroke, but it might really help your stroke, recovery, but. Bill Gasiamis (49:47)which Jack Clifford (50:03)Anyhow, so like you can, you know, I don’t know about in Australia, but in the United States, you could get an EECP machine and create a viable business model off of helping people as soon as people actually know about it and what it does, right? I’m trying to solve the access issue in the United States by aggregating demand, right, as one of the solutions. So I have a website, eecplocator.com. And if people… ⁓ tell me that they like EECP to be available in their area, when I get like five to 10 patients in one area, we’re gonna find a way to get it to them. ⁓ The how is, you there’s a bunch of different possible ways we can get EECP to them, but at the end of the day, you know, like people need this treatment. They really, really do. Bill Gasiamis (50:50)Yeah. We’re not talking about anything ⁓ out there. Like this is not an out there thing. This is definitely common. Now I, I don’t know how I haven’t come across it. I’ve all these years after all these years now I’ve just because of our conversation right now, I just did a Google search and I typed in EECP machine Australia. And the first thing that came up was an Australian government department of health, disability and aging. Jack Clifford (50:57)No, it’s that. Bill Gasiamis (51:20)document from the Therapeutic Goods Administration, which talks about a mid-trade Australia EECP system model, external counter pulsation system stationary. So it seems like they have a… Jack Clifford (51:36)Like they’ve approved it, sounds like they have some approved devices. Yeah. Bill Gasiamis (51:38)Something like they’re at least looking at it. Let me see what that says. The inclusion of the kind of device in the AI community is subject to compliance with conditions placed in post. Yeah, it sounds like it’s been through some regulated body in 2021. Jack Clifford (51:52)Yeah. Mm-hmm. Yep. There you go. Bill Gasiamis (51:57)This device is intended to provide external counter pulsation therapy and is indicated for use in the treatment of stable angina. Jack Clifford (52:06)Mm-hmm. Bill Gasiamis (52:08)pectoris and congestive heart failure. There you go, my friend. Jack Clifford (52:10)Yeah, it works great for people with art failure. It really does. Bill Gasiamis (52:14)Dude, father-in-law had heart failure. He passed away from heart failure just a few, about a year and a half ago. ⁓ Now, I don’t know, I’m not saying anything, but we’ve never heard of this before. Today’s my first time where I’m really going to deep dive about this thing with you. ⁓ So what are the challenges that you face? what are the, what is it? ⁓ The barriers that you face? Jack Clifford (52:20)Yeah. Bill Gasiamis (52:44)when you’re speaking to people about this or how people finding out about it, how do you help people like Jack Clifford (52:50)It’s just an awareness piece. It’s an EECP what? And then, you you get in with some physicians and then you got to duke it out a little bit. Not with all of them. There’s plenty of physicians, you know, I’ve talked to the physicians that have machines and are doing the right thing for society and still making plenty of money. ⁓ They’ll just tell you, you know, I’ve talked to some cardiologists and just they kno

Peptides are everywhere in the health & performance world—but what are they actually? In this episode, Andrew breaks down what peptides are, why they've exploded in popularity, and what research has and hasn't been done.We'll e go deeper on two of the most talked-about peptides: BPC-157 (Body Protection Compound) and GHK-Cu (copper tripeptide). We cover what they're commonly used for (tendon/ligament recovery, wound healing, gut support, skin and hair), the proposed mechanisms (inflammation regulation, nitric oxide support, angiogenesis, collagen/elastin signaling), and circumstances where Andrew would recommend avoiding them (active cancer or a strong cancer concern due to blood vessel growth signaling).If you've been hearing peptide hype online and want a grounded overview—this is your starting point.Chapters00:00 Why Peptides Are Trending01:23 What Peptides Are04:10 Recovery and Anti-Aging08:05 Where to Get Peptides13:30 BPC-157 For Gut, Tendons, Ligaments, and Wounds23:10 BPC-157 For Inflammation, Nitric oxide, Angiogenesis, Growth-Hormone Receptors38:40 Andrew's experience50:30 GHK-Cu For Healing, Antioxidants, Brain, Skin, and HairThe Co-Movement Gym Podcast is supported by Native Path Supplements and Lombardi Chiropractic.

In this episode, host Chris Duffin sits down with guest Anthony Castor for a deep dive into the world of recovery, healing, and performance optimization—specifically through the lens of peptides and beyond. Building on their recent conversation, Chris reveals his unique framework for developing cutting-edge recovery protocols, which combines four essential pillars: cellular, neurological, biomechanical, and hydrodynamic approaches. Together, they unpack how these modalities—ranging from peptide therapies and blood flow restriction to innovative equipment design and red light therapy—can be strategically layered for maximum results without redundancy. Listen in as Chris and Anthony share game-changing insights, remarkable case studies, and a behind-the-scenes look at the thought process that underpins some of today's most advanced healing methods.   Here are my top 3 takeaways: Four “Unlocks” to Human Physiology: Chris's model addresses cellular, neurological, biomechanical, and hydrodynamic (fluid/nutrient movement) factors—stacking recovery and training modalities for maximum results. Synergy > Redundancy: Instead of relying on a single method (like just peptides or just BFR), Chris stresses building protocols that combine different tools—shockwave, red light therapy, blood flow restriction, etc.—to trigger adaptation through multiple pathways for accelerated and more sustainable healing. Framework Over Fads: The most effective coaches and protocols don't just copy what works for others. They adapt and personalize, choosing the right tools based on goals, willingness, and lifestyle—always learning from diverse experts and continuously building the right system for the individual.   This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by  @marekhealth : Performance. Longevity. Optimization.

For this week's episode of the Clinician's Corner, we've gone into the archives to pull out another clinical pearl from one of our favorite episodes - and today we discuss the world of integrative cancer care with Dr. Nasha Winters.   This interview first aired back in 2023, and the full interview can be viewed here.    Clinical pearls we extracted from the original interview:        The “cancer terrain” concept and its drivers (Dr. Nasha highlights the top 10)      Diet, nutrition, and cancer      The modern state of metabolic health - and misconceptions about metabolic markers      The role of ketosis and therapeutic diets in cancer      Testing and lab assessment for personalized nutrition       Therapeutic ketosis in pediatric cases   The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/    Join us for a FREE 3-Part Fertility Masterclass Series: Precision Nutrition for Fertility Grab your spot now!    Connect with Dr. Nasha Winters:   Website: https://www.drnasha.com Facebook: https://www.facebook.com/drnashainc/ and https://www.facebook.com/mtih.org Instagram: https://www.instagram.com/drnashawinters/ and https://www.instagram.com/mtihorg LinkedIn: https://www.linkedin.com/in/nasha-winters-796374b6/ Twitter: https://twitter.com/drnashawinters and https://twitter.com/MTIH_Terrain YouTube: https://www.youtube.com/c/drnashainc/videos?app=desktop    For more information on the Metabolic Terrain Institute of Health: https://mtih.org Additional Resources from Dr. Nasha: Education Resources: https://www.drnasha.com/matcbook/ The Mistletoe Book: https://www.themistletoebook.com MTIH - Practitioner Terrain Network: https://terrain.network/tap/    Timestamps:  00:00 Understanding Cancer's Growing Impact 03:20 "Integrative Cancer Care: Bridging Worlds" 08:29 Toxicity, Microbiome, and Individual Sensitivity 10:55 Circadian Rhythm and Holistic Stressors 13:31 Diet's Impact on Metabolic Health 17:55 Inconsistent Blood Sugar Standards 22:12 "Reevaluating Diet Myths: Fat vs. Sugar" 24:47 Personalized Metabolic Health Strategies 28:21 Alternative Ketosis Methods Explored 32:28 Fertility Masterclass Invitation 35:00 Inaccuracies in Cell Line Studies 37:37 "Ketosis: Impact on Cancer & Epilepsy" 41:53 DIPG Support and Resource Hub 44:07 "Clinician's Corner: Join & Share" Speaker bio: Dr. Nasha Winters is a global healthcare authority and best-selling author in integrative cancer care and research consulting with physicians around the world. She has educated hundreds of professionals in the clinical use of mistletoe and has created robust educational programs for both healthcare institutions and the public on incorporating vetted integrative therapies in cancer care to enhance outcomes.  She is currently focused on opening a comprehensive metabolic oncology hospital and research institute in the U.S. where the best that standard of care has to offer and the most advanced integrative therapies will be offered. This facility will be in a residential setting on a gorgeous campus against a backdrop of regenerative farming, EMF mitigation and retreat, as well as state of the art medical technology and data collection and evaluation to improve patient outcomes.   Keywords:  cancer treatment, metabolic health, integrative medicine, functional health, ketogenic diet, therapeutic ketosis, metabolic flexibility, terrain theory, epigenetics, toxins, microbiome, immune function, inflammation, angiogenesis, blood sugar, insulin resistance, lipid profile, fasting, intermittent fasting, circadian rhythm, stress management, mental health, spiritual wellness, pediatric cancer, nutritional therapies, alternative medicine, complementary medicine, oncology, laboratory testing, diet personalization Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Ever feel like your workouts just aren't delivering the same results anymore? You're training hard, lifting heavy, and doing everything “right,” but somehow, progress stalls. Strength fades. Recovery slows. And your joints? Yeah, they're not loving it either.Here's the truth: it's not your age—it's your approach.That's why I brought in Nick Nilsson, aka The Mad Scientist of Muscle. This guy has spent decades reinventing the way we build muscle, train smart, and stay strong—especially as we get older. His Return to Prime system isn't about grinding yourself into the ground. It's about training smarter, not harder, by optimizing the four key systems that fuel muscle growth.I put his method to the test, and let me tell you—it humbled me in the best way possible. This workout forced my body to adapt in ways I didn't even think were possible.Timestamps:09:29 Nick's origin story and fitness background21:00 How Nick created his "best exercises you've never done" brand28:48 The inspiration behind the Return to Prime program33:36 Phase 1: Angiogenesis training for rebuilding circulation46:08 Phase 2: Connective tissue training and hydraulic circulation1:00:14 Phase 3: Hyperplasia training for increasing muscle fiber numbers1:10:30 Phase 4: Nervous system efficiency and activation training1:24:42 Nutrition recommendations for each training phase1:32:10 Final thoughts: Have fun whith training!Mentioned Resources:Mad Scientist of Muscle website: https://www.madscientistofmuscle.com/ The Best Exercises You've Never Heard Of: https://www.fitstep.com/2/the-best-exercises-index/index.htm Return to Prime: https://www.fitstep.com/2/return-to-prime/index-story.htm

In this episode of The Visible Voices Podcast, Dr. William Li, a physician researcher and CEO founder of The Angiogenesis Foundation, joins to talk about starving cancer with food and more generally about food as medicine. We discuss the concept of angiogenesis, the impact of diet on cancer, and debunk common myths surrounding coffee, soy, and eggs. Dr. Li emphasizes the importance of nutrition education in medical training and shares recent discoveries about the health benefits of oats.  Will reflects on the challenges of communicating complex medical concepts to the public and the significance of empowering patients with knowledge about their health.  Some conversation learning points:Food is a powerful tool in preventing disease. Angiogenesis is a key factor in cancer development. Soy does not cause breast cancer; it may actually help. Nutrition education is lacking in medical training. High-quality eggs can be beneficial for health. Oats contain bioactives that promote gut health. Coffee has anti-inflammatory and anti-cancer properties. Dietary fiber is essential for cancer patients. Empowering patients can lead to better health outcomes. Check out Will's content: 2023 Eat to Beat Your Diet (book) 2021 Eat to Beat Disease (book) 2010 Can We Eat To Starve Cancer? (TED Talk) If you enjoy the show, please leave a ⭐⭐⭐⭐⭐ rating or review on Apple or YouTube , subscribe via the Website and forward to a friend.

Guest Kristy Red-Horse is a biologist who specializes in coronary artery development and disease. She says the latest advances in treatment of blockages could do away with invasive bypass surgeries in favor of growing new arteries using molecules like CXCL12, known to promote artery regrowth in mice. Red-Horse explains how leaps forward in medical imaging, expanding atlases of gene expressions, and new drug delivery mechanisms could someday lead to trials in humans. But, before that day can arrive, much work remains, as Red-Horse tells host Russ Altman in this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Kristy Red-HorseKristy's Lab: Red-Horse LabConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Kristy Red-Horse, a professor of biology at Stanford University.(00:03:46) Replacing Open-Heart SurgeryWhy bypass surgery is invasive, risky, and requires long recovery.(00:05:09) Challenges in Artery GrowthThe difficulty of targeting artery growth with medical interventions.(00:07:32) The Role of Collateral ArteriesDefinition and function of collateral arteries as natural bypass.(00:09:37) Triggers for Natural Bypass FormationGenetic factors that may influence the growth of these bypass arteries.(00:10:49) Unique Properties of Coronary ArteriesChallenges of ensuring artificial growth replicates natural artery function.(00:13:04) The Discovery of CXCL12A key molecule that stimulates collateral artery formation.(00:16:16) Precise Artery Growth ControlThe results of targeted CXCL12 injections into mice hearts.(00:17:32) CXCL12's Overlooked RoleThe molecule's role in the immune system and stem cells.(00:20:27) Guinea Pigs and Heart Attack ResistanceHow guinea pigs naturally develop collaterals.(00:23:19) Preventing Heart DiseaseUsing artery growth treatments to target early-stage coronary disease.(00:25:25) Breakthroughs in Imaging TechnologyNew technology that enables identification of collateral growth pathways.(00:27:07) How Collateral Arteries FormThe two mechanisms in which new arteries form.(00:28:48) The Future of Medical Artery GrowthThe possibility of eliminating bypass surgery with targeted artery growth. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

References:Weight loss on GLP-1 receptor agonistsMoiz A, Levett JY, Filion KB, et al. Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Cardiol 2024, 222:121-130.Highlights: On average, weight loss on semaglutide (Ozempic) is approximately 15% of body weight.Gastrointestinal adverse effects of GLP-1 receptor agonistsSodhi M, Rezaeianzadeh R, Kezouh A, Etminan M. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss. JAMA 2023.Nutrient Density and Satiety:Drewnowski, A.. Concept of a nutritious food: toward a nutrient density score. The American Journal of Clinical Nutrition 2005. Nutrient-dense foods like greens and beans have been shown to promote satiety, support weight loss, and provide essential micronutrients.Highlights: Nutrient-dense foods can naturally regulate appetite and reduce caloric intake without sacrificing nutrition.Anti-Angiogenic Effects of Vegetables and Mushrooms:Li WW, Li VW, Hutnik M, Chiou AS. Tumor angiogenesis as a target for dietary cancer prevention. J Oncol 2012, 2012:879623. Certain foods, like cruciferous vegetables and green tea, have anti-angiogenic properties that not only combat tumor growth.Corvera S, Solivan-Rivera J, Yang Loureiro Z. Angiogenesis in adipose tissue and obesity. Angiogenesis 2022, 25:439-453.Cao QZ, Lin ZB. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta pharmacologica Sinica 2004, 25:833-838.Highlights: Anti-angiogenic foods limit blood vessel growth in fat cells, aiding in long-term weight management.Role of Fiber in Appetite Suppression:Slavin, JL. Dietary fiber and body weight. Nutrition. 2005. High-fiber foods, such as beans and greens, slow digestion, lower postprandial glucose levels, and enhance satiety, contributing to sustainable weight loss.McRorie JW, Jr., McKeown NM. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. J Acad Nutr Diet 2017, 117:251-264.Highlights: Fiber promotes healthy gut microbiota, which indirectly regulates appetite, and viscous fiber directly regulates appetite by slowing breakdown of macronutrients.Green Tea and Weight Regulation:Neyestani TR, Nikooyeh B. A comprehensive overview on the effects of green tea on anthropometric measures, blood pressure, glycemic and lipidemic status: An umbrella review and meta meta-analysis study. Nutr Metab Cardiovasc Dis 2022, 32:2026-2040. Green tea's catechins and mild caffeine content have been shown to modestly increase fat oxidation and support metabolic health.Highlights: Green tea is a natural complement to weight-loss strategies.Nut Consumption and Caloric Absorption:Tindall AM, Petersen KS, Lamendella R, et al. Tree Nut Consumption and Adipose Tissue Mass: Mechanisms of Action. Curr Dev Nutr 2018, 2:nzy069.Highlights: Whole nuts, not oils, reduce caloric intake without compromising satisfaction.

Connect with Dr. Craig Robbins: limblengthening.org Have questions about peptides and recovery? Drop them in the comments below, and we'll try to answer them during the livestream! #Peptides #BPC157 #TB500 #SurgeryRecovery #LimbLengthening #PostSurgeryHealing #Cyborg4Life #DrCraigRobbins #DrScottWillis ________ Audio Podcast: will be available within 48hrs when stream ends Timestamps: 0:00 - Intro Music0:25 - Welcome to Episode 1420:37 - Introducing Dr. Craig Robbins and Dr. Scott Willis1:05 - Dr. Willis' Expertise and Background1:35 - Overview of Peptides for Recovery2:06 - Dr. Robbins' Initial Thoughts on Peptides2:53 - Peptides vs. Natural Healing3:23 - Masterclass on Peptides with Dr. Scott Willis3:39 - What Are Peptides?5:01 - Peptides and Post-Surgical Recovery6:06 - Popular Recovery Peptides: BPC-157 and TB-5008:14 - Angiogenesis and Healing Properties of BPC-1579:31 - Effectiveness of Peptide Injections vs. Oral Peptides10:18 - FDA Regulations on Peptides12:26 - The Wolverine Stack: BPC-157 and TB-50016:01 - Anti-Inflammatory Properties of Peptides19:05 - Peptides vs. Testosterone and Growth Hormone21:18 - Growth Hormone Releasing Peptides (Secretagogues)24:19 - The Role of Testosterone in Healing27:12 - Optimizing Recovery for Older Patients30:01 - Challenges of Recovery After Surgery32:10 - Peptides for Bone Healing in Consolidation Phase35:05 - Risks of Self-Administering Peptides38:09 - Protocols for Optimized Recovery41:04 - Importance of Protein and Nutrition44:06 - Synergy Between Peptides and Nutrition46:45 - Peptides for Sleep: Delta Sleep Inducing Peptide (DSIP)48:53 - Anecdotal Evidence for Peptide Effectiveness50:49 - Combining Therapies for Recovery55:05 - Exploring Additional Peptides: GHK-Cu and DSIP59:01 - Future of Peptides in Medicine1:02:26 - Practical Challenges and FDA Lists1:04:43 - Lifestyle Medicine and Chronic Health Solutions1:07:29 - Dr. Robbins' Insights on Limb Lengthening Recovery1:12:04 - Gym Equipment Enthusiasm with Dr. Willis1:17:19 - Victor's Bodybuilding Journey1:25:02 - Closing Remarks ________

In this episode of the Thrive State Podcast, Dr. Kien Vuu sits down with Dr. William Li, a world-renowned medical doctor and researcher, to explore the groundbreaking science of angiogenesis—the process by which new blood vessels are formed in the body. They dive into how angiogenesis affects everything from cancer prevention to healing and longevity. Dr. Li shares powerful insights on how the food we eat can influence our health at the cellular level and offers practical advice on how to optimize your diet for disease prevention and overall well-being. Don't miss out on this fascinating conversation on how the right foods can boost your health and healing power. Tune in to learn more! Episode Highlights: What is Angiogenesis? The Link Between Angiogenesis and Disease How Foods Influence Angiogenesis Foods that Fight Cancer and Other Diseases Practical Tips for Everyday Wellness The Future of Medicine and Food

BUFFALO, NY- December 4, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 22, 2024, entitled, “The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells.” Researchers Murad K. Nazzal, Hanisha L. Battina, Nikhil P. Tewari, Sarah L. Mostardo, Rohit U. Nagaraj, Donghui Zhou, Olatundun D. Awosanya, Saveda K. Majety, Sue Samson, Rachel J. Blosser, Ushashi C. Dadwal, Patrick L. Mulcrone, and Melissa A. Kacenaat from Indiana University School of Medicine and Richard L. Roudebush Veterans' Administration Medical Center, have uncovered how certain bone marrow cells, called megakaryocytes (MKs), promote the growth of new blood vessels (angiogenesis) to aid in bone healing. Their findings help explain why healing slows with age and offer insights into potential treatments to accelerate fracture recovery in older adults. Broken bones are common in older adults, and slower healing can lead to complications and longer hospital stays. Accelerating the healing process could significantly improve the quality of life for millions. In this study, researchers investigated the effects of substances secreted by MKs, collected from young and older male and female mice. These substances, known as conditioned media (CM), were tested for their ability to stimulate the growth and function of endothelial cells (EC), which form the building blocks of blood vessels. Blood vessels play a critical role in healing by delivering oxygen and nutrients to damaged areas, making angiogenesis a vital part of the recovery process. The results showed that CM from younger MKs mice was more effective at helping blood vessels grow. Interestingly, MKs from female mice performed better than those from males, regardless of age. For example, substances from female MKs mice boosted blood vessel growth by over 115% and significantly improved the movement of cells needed for healing. The researchers also studied changes in genes related to blood vessel growth, and found that aging affects how these genes work. These changes may explain why older people heal more slowly after breaking a bone. “An understanding of which factors regulate which mechanisms of EC functionality may allow for isolation of one or a few factors that influence EC migration changes with aging, resulting in the development of targeted therapy to improve EC migration, subsequent angiogenesis, and fracture healing.” In conclusion, this research paves the way for developing new therapies to help older individuals recover from fractures more quickly, reducing pain and improving mobility. One potential approach could involve creating treatments that replicate the effects of MKs from younger individuals or isolating the specific substances that promote blood vessel growth. This represents an important step toward addressing the growing challenge of delayed healing in an aging population. DOI - https://doi.org/10.18632/aging.206077 Corresponding authors - Patrick L. Mulcrone - pamulcro@iu.edu, and Melissa A. Kacena - mkacena@iupui.edu About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

In this episode, hosts Reed Davis and Dr. Gonshor delve into the surprising research on how antioxidants, commonly seen as beneficial, can stimulate BAC1-dependent tumor angiogenesis, potentially aiding the growth and spread of cancerous tumors. They explain the mechanism by which vitamin C and other antioxidants contribute to new blood vessel formation in tumors, discuss the implications for cancer patients, and emphasize the need for careful consideration of antioxidant use. The episode also touches on recent findings regarding the incidence of long COVID with different coronavirus variants and underscores the importance of healthy lifestyle choices.  Get Functional Diagnostic Nutrition's best free resources at fdntraining.com/resources.

In this episode of the Life of Flow podcast, hosts dive deep into the cutting-edge world of limb salvage surgery with Dr. Michael Theodoulou, a podiatrist, Assistant Professor of Surgery at Harvard Medical School, and Chief of Foot and Ankle Surgery at Cambridge Health Alliance. Dr. Theodoulou introduces listeners to an innovative approach called distraction angiogenesis, which is helping patients with severe lower extremity conditions that have left them with "no option" for treatment. Dr. Theodoulou on the Impact of Distraction Angiogenesis:"We've seen significant improvements in blood flow and healing in patients with no other options. The angiogenesis response from controlled fractures can be remarkable." Hosts on the Future of Vascular Surgery:"There's a real intellectual curiosity here, and the results are exciting. Techniques like this could change how we approach limb salvage."

The fields of Cell and gene therapy are booming and poised to change the treatment and prevention of disease. These research areas require the transfer of genetic material to cells, and viral vectors are commonly used here. Specifically, adeno-associated virus (AAV) and lentiviral vectors (LVV) are vectors of choice. We're joined for this episode by MinGin Kim and Kimberly Gomez, both scientists at Thermo Fisher. With backgrounds and expertise in the areas of cell and gene therapy, they help explain what all the excitement is about and how AAV and LVV are used. We hear about some of the challenges associated with viral vector work and get to hear about how digital PCR (dPCR) and good assay design are helping overcome many of these challenges to enable research and the biopharmaceutical industry. As you might expect from Absolute Gene-ius, you also get to hear their respective career path journeys and some really interesting lab stories.Visit the Absolute Gene-ius page to learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23, pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination.  This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateína: https://drinkmateina.com/huberman Levels: https://levels.link/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Peptides (00:03:20) Sponsors: Mateina, Levels & Joovv (00:07:44) What is a Peptide? (00:12:06) Peptide Sourcing, Lipopolysaccharide (LPS) (00:14:48) Rejuvenation & Tissue Repair: BPC-157, Angiogenesis (00:21:50) BPC-157 & Tissue Injury; Mode of Delivery (00:27:53) BPC-157: Safety, Doses, Cycling, Tumor Risk (00:35:16) Sponsor: AG1 (00:36:43) Tissue Repair: Thymosin Beta-4, TB-500 (00:40:49) Growth & Metabolism: Growth Hormone, IGF-1, Risks (00:45:25) Secretagogues, Sermorelin, Tesamorelin, CJC-1295 (00:52:21) Sponsor: LMNT (00:53:44) Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing (00:58:69) Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing (01:06:12) Longevity: Thymosin Beta-4, Epitalon (Epithalon) (01:12:09) Vitality: Melanotan, PT-141 (Vyleesi), Risks (01:17:21) Vitality: Kisspeptin (01:21:46) Peptides, Potential Benefits, Side-Effects & Risks (01:24:19) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

Get early access to The Perfect Health Lesson, and the classroom and FREE web class that are discussed in today's lesson. ⁠⁠⁠⁠⁠Click this link now⁠⁠⁠⁠⁠ In today's episode: Raising your CRF score, which reflects your body's ability to utilize oxygen during exercise, triggers several molecular and physiological adaptations that contribute to the formation of new blood vessels (angiogenesis) and the remodeling of existing arteries (arteriogenesis). Here's how these processes occur and contribute to lowering your clinical risk of cardiovascular disease: Increased Oxygen Demand: When you engage in physical activity, your muscles require more oxygen to meet the increased energy demands. This elevated oxygen demand stimulates the release of signaling molecules such as vascular endothelial growth factor (VEGF) and nitric oxide (NO) within the vascular endothelium. Stimulation of Angiogenesis: VEGF is a key factor in promoting the growth of new blood vessels (angiogenesis) from pre-existing ones. This process helps to expand the network of blood vessels, improving oxygen delivery to tissues and organs. Enhanced angiogenesis ensures adequate blood supply to active tissues, reducing the risk of ischemia and promoting tissue repair and regeneration. Promotion of Arteriogenesis: Nitric oxide (NO), produced by endothelial cells in response to increased blood flow and shear stress, plays a crucial role in arteriogenesis. More inside the episode...

Dr. Philip Rosenfeld joins to discuss the Angiogenesis 2024 meeting, with topics covered including imaging breakthroughs for age-related macular degeneration, geographic atrophy treatment benefits and risks, and the importance of molarity in assessing efficacy and safety of intravitreal agents.Relevant Financial Disclosures: Dr. Rosenfeld has consulted for Regeneron and Zeiss. Dr. Sridhar has consulted for Apellis, Genentech, Iveric, and Regeneron.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Episode Highlights With Katrina FoeThe root drivers of cancer and what we all need to know to avoid itLess than 10% of cancers are genetically inheritedThe root cause drivers of cancer and the tests that relate to themWhat the metabolic drivers of cancer arePreventative tests that can indicate early cancer riskHow hormones relate to cancerMicrobiome connections to cancer and what to know to improve itWhat angiogenesis is and why it mattersHow environmental toxins can relate to cancerThe emotional component to any diagnosis Why she got kicked out of the cancer treatment clinic and why she is so grateful for itHer take on coffee enemas Why too much protein isn't ideal with her cancer protocolThe therapeutic ranges for ketosisResources We MentionCancer FreedomInstagram - KatrinaNutritional Pilates: Relieve Joint Pain, Lose Unwanted Weight, and Prevent Chronic Disease to Become Your Most Vibrant Self by Katrina FoeTripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms by Travis ChristoffersonThe Roadmap to Prevent Cancer Recurrence - Free ebook watercheck.comLevels Glucose MonitorKeto monitor

Break out your dictionaries! Michelle dives in to explaining all about phytonutrients and other words Kevin isn't brave enough to try to pronounce. But don't worry - they really aren't that scary... in fact, they are the nutritional superheroes! They can help your body fight lots of nasty diseases and conditions - and they're so easy to find!

The creation of new blood vessels can fuel tumors and the accumulation of body fat

In this episode of The Luke Coutinho Show, I am privileged to bring you an eye-opening discussion with the internationally acclaimed, Dr. William Li, a physician, Harvard-scientist, and NYT bestselling author of the groundbreaking books -  ‘Eat To Beat Your Diet' and ‘Eat To Beat Disease.' Delve into the science of food as medicine as we discuss: The 'why' behind nutrition and meaningful lifestyle changesThe five health defense systems: Angiogenesis, DNA, microbiome, immunity, and stem cellsThe role of food in activating the body's defense systems and preventing diseasesModern molecular science in nutritionThe link between cancer, DNA, inflammation, and angiogenesisThe 'Goldilocks zone' where our body precisely manages food intakeImpact of genetically modified organisms (GMOs) on health and the gutAnd much more…

If you're looking to improve your circulation / blood flow and athletic performance or simply combat increased vascular permeability (which can create edema and, therefore, hypoxia) due to the damaging effects of hyperglycemia, inflammation, toxins, etc..., then this episode is a MUST-listen! We're delving into the intricacies of the vesugen bioregulator peptide – so stay tuned for some pretty intriguing research! Topics: 1. Introduction to the Episode - Previous background interest in vesugen: Lyme and Mold / CIRS issues - Introduction to bioregulator peptide vesugen - Effects on blood vessels, circulation, hypoxia, and athletic performance 2. Quick Overview of CIRS and the Circulatory System - Damage to the endothelial blood vessel wall due to high MMP-9 levels - Hemolysins released by MARCoNS - Narrowed capillaries and induced hypoxia - Interest in vesugen 3. Blood Cell Formation - Hematopoiesis - Process and origin in the bone marrow - Characteristics of multipotent hematopoietic stem cells (HSCs) - Regulation of HSC self-renewal vs. differentiation - Myeloid and Lymphoid Progenitors - Differentiated blood cells from each progenitor type - Pathway: Myeloid progenitor to erythrocyte - Role of Erythropoietin (EPO) 4. Maturation Process of Erythrocytes - Ejection of nucleus and organelles - Hemoglobin acquisition - Biconcave shape for optimal gas exchange - Transition to the bloodstream via sinusoids 5. Vascular Wall Anatomy and Dysfunction - Overview of vascular wall layers: Tunica intima, tunica media, and tunica externa - Detailed understanding of endothelial cell functions - Barrier function and vascular permeability - Vascular tone and blood flow regulation - Inflammation and the role in immune response - Angiogenesis and its significance 6. Bioregulator Peptide Vesugen - Definition and unique characteristics - Composition: Lysine, Glutamine, and Asparagine - Mechanism of action: Promotion of endothelial cell proliferation 7. Benefits and Potential of Vesugen - Restoration of endothelial function - Role in injury and endothelial dysfunction scenarios: edema, hypoxia, etc... - Protective effect on the blood-brain barrier - Impact on nitric oxide production and athletic performance, hair growth, skin health Thanks so much for tuning in! Pre-Order Chloe's Book "⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Drs Michelle Kittleson and Bonnie Ky discuss the field of cardio-oncology and how cancer treatment-related cardiotoxicity can be prevented, detected, and treated to improve the quality of cancer survivorship. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/982164). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Heart Failure https://emedicine.medscape.com/article/163062-overview Cardio-oncology: A New and Developing Sector of Research and Therapy in the Field of Cardiology https://pubmed.ncbi.nlm.nih.gov/30073443/ Cardiovascular Effects of Neuregulin-1/ErbB Signaling: Role in Vascular Signaling and Angiogenesis https://pubmed.ncbi.nlm.nih.gov/24283954/ Heart Failure in Patients With Cancer Treated With Anthracyclines-Revisiting the Foundation of Cardio-oncology https://pubmed.ncbi.nlm.nih.gov/36735260/ 2022 ESC Guidelines on Cardio-oncology Developed in Collaboration With the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS) https://pubmed.ncbi.nlm.nih.gov/36017568/

Expanding body fat releases blood supply-generating factors that may end up hooking up tumors, too.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.16.549192v1?rss=1 Authors: Torres-Espin, A., Rabadaugh, H., Fitzsimons, S., Chou, A., Harvey, D., Lindberg, C., Goldberger, L., Casaletto, K. B., Staffaroni, A., Maillard, P., Miller, B. L., Hinman, J. D., DeCarli, C., Ferguson, A. R., Kramer, J., Elahi, F. M. Abstract: Aberrant angiogenesis could contribute to cognitive impairment, representing a therapeutic target for preventing dementia. However, most angiogenesis studies focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in two deeply phenotyped human cohorts (n=435, age 74+9) with longitudinal cognitive assessments, biospecimens, structural brain imaging, and clinical data. Machine learning and traditional statistics revealed sex dimorphic associations of plasma angiogenic growth factors with brain aging outcomes. Specifically, angiogenesis is associated with higher executive function and less brain atrophy in younger women (not men), a directionality of association that reverses around age 75. Higher levels of basic fibroblast growth factor, known for pleiotropic effects on multiple cell types, predicted favorable cognitive trajectories. This work demonstrates the relevance of angiogenesis to brain aging with important therapeutic implications for vascular cognitive impairment and dementia. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.10.548410v1?rss=1 Authors: Biswas, S., Shahriar, S., Bachay, G., Arvanitis, P., Brunken, W. J., Agalliu, D. Abstract: Interactions among neuronal, glial and vascular components are crucial for retinal angiogenesis and blood-retinal barrier (BRB) maturation. Although synaptic dysfunctions precede vascular abnormalities in many retinal pathologies, how neuronal activity, specifically glutamatergic activity, regulates retinal angiogenesis and BRB maturation remains unclear. Using in vivo genetic studies in mice, single cell RNA sequencing and functional validation, we show that deep plexus angiogenesis and paracellular BRB maturation are delayed in Vglut1-/- retinas, where neurons fail to release glutamate. In contrast, deep plexus angiogenesis and paracellular BRB maturation are accelerated in Gnat1-/- retinas, where constitutively depolarized rods release excessive glutamate. Norrin mRNA expression and endothelial Norrin/{beta}-catenin activity are downregulated in Vglut1-/- retinas, and upregulated in Gnat1-/- retinas. Pharmacological activation of endothelial Norrin/{beta}-catenin signaling in Vglut1-/- retinas rescued defects in deep plexus angiogenesis and paracellular BRB integrity. Our findings demonstrate that glutamatergic neuronal activity regulates retinal angiogenesis and BRB maturation by modulating Norrin/{beta}-catenin signaling. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Get ready to embark on an electrifying journey that will revolutionize your relationship with food and health!In this mind-blowing episode, you'll learn how to “Eat your way to better health." And who better to guide us than the extraordinary DR. WILLIAM LI—the world's foremost authority on the incredible power of food.Oh and yea , we're discussing Ozempic and similar injections AND Groundbreaking work on Cancer cells! This is something you have NEVER heard before!Dr. Li is about to unveil the secrets that will rock your understanding of nutrition and well-being. With over 40 FDA-approved breakthroughs under his belt, revolutionizing cancer treatment, cardiovascular health, wound healing, vision restoration, and NYT Bestselling book, his expertise is unparalleled.Brace yourself for this groundbreaking exploration of FOOD AS MEDICINE packed with game-changing insights that will directly impact your health—no matter where you are on your health journey!Prepare to take notes as we uncover:How to EAT your way to healthThe profound effects of EXTREME and FAD DIETING, both the good and the badThe dangers of relying on PRESCRIPTION DRUGS for weight lossA comprehensive exploration of ANGIOGENESIS and its implications for overall healthUnderstanding the critical role of HEALTHY BLOOD VESSELS in maintaining well-beingUncovering how food influences INFLAMMATION within the bodyAn eye-opening discussion on the daily formation of CANCER CELLS in our bodiesThe significance of embracing WHOLE FOODS to optimize healthThe impact of WHITE FAT AND BROWN FAT on our bodiesAND Dr. Li shares his cutting-edge research that will forever reshape your understanding of your body's metabolic processes and the connection between SLEEP, INTERMITTENT FASTING, and your body's ability to unleash its fat-burning superpowers.Dr. Li's groundbreaking insights on HARNESSING THE POWER OF EVERYDAY FOODS will activate your body's hidden potential, unleashing a new era of vitality and long-term health and revolutionize your well-being!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.19.537575v1?rss=1 Authors: Zink, J., Froemel, T., Boon, R. A., Fleming, I., Benz, P. M. Abstract: Endothelial tip cells are essential for VEGF-induced angiogenesis, but underlying mechanisms are elusive. Endothelial-specific deletion of EVL, a member of the mammalian Ena/VASP protein family, reduced the expression of the tip cell marker protein endothelial cell specific molecule-1 (Esm1) and compromised the radial sprouting of the vascular plexus in the postnatal mouse retina. The latter effects could at least partly be attributed to reduced VEGF receptor 2 (VEGFR2) internalization and signaling but the underlying mechanisms(s) are not fully understood. In the present study, we revealed that the expression of the long non-coding RNA H19 was significantly reduced in endothelial cells from postnatal EVL-/- mice and in siRNA-transfected human endothelial cells under hypoxic conditions. H19 was recently shown to promote VEGF expression and bioavailability via Esm1 and hypoxia inducible factor 1 (HIF-1). Similar to EVL-/- mice, the radial outgrowth of the vascular plexus was significantly delayed in the postnatal retina of H19-/- mice. In summary, our data suggests that loss of EVL not only impairs VEGFR2 internalization and downstream signaling, but also impairs VEGF expression and bioavailability in the hypoxic retina via downregulation of lncRNA H19. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

A new research paper was published in Oncotarget's Volume 14 on February 2, 2023, entitled, “Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC).” TP53 mutant head and neck squamous cell carcinoma (HNSCC) patients exhibit poor clinical outcomes with 50–60% recurrence rates in advanced stage patients. In a recent phase II clinical trial, adjuvant therapy with everolimus (mTOR inhibitor) significantly increased 2-year progression-free survival in p53 mutated patients. TP53-driven mTOR activation in solid malignancies causes upregulation of HIF-1α and its target, downstream effector VEGF, by activating STAT3 cell signaling pathway. In this recent study, researchers Md Maksudul Alam, Janmaris Marin Fermin, Mark Knackstedt, Mackenzie J. Noonan, Taylor Powell, Landon Goodreau, Emily K. Daniel, Xiaohua Rong, Tara Moore-Medlin, Alok R. Khandelwal, and Cherie-Ann O. Nathan from LSU-Health Sciences Center investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. “The role of mTOR inhibitors (mTORi) as potent growth inhibitory and antiangiogenic/anti-lymphangiogenic agents in HNSCC is well established [18]. Moreover, mTORi significantly suppressed baseline invasiveness of endothelial and HNSCC tumor cells [19]. However, the underlying molecular mechanisms for mutant p53 protein-mediated activation of the mTOR pathway which drive the oncologic processes in HNSCC are yet to be elucidated.” Treatment with everolimus significantly inhibited cell growth in vitro and effectively reduced the growth of TP53 mutant xenografts in a minimal residual disease (MRD) model in nude mice. Everolimus treatment was associated with significant downregulation of STAT3/HIF-1α/VEGF pathway in both models. Further, treatment with everolimus was associated with attenuation in tumor angiogenesis and lymphangiogenesis as indicated by decreased microvessel density of vascular and lymphatic vessels in HN31 and FaDu xenografts. Everolimus downregulated the STAT3/HIF-1α/VEGF pathway to inhibit growth and in vitro tube formation of HMEC-1 (endothelial) and HMEC-1A (lymphatic endothelial) cell lines. “Our studies demonstrated that everolimus inhibits the growth of TP53 mutant tumors by inhibiting angiogenesis and lymphangiogenesis through the downregulation of STAT3/HIF-1α/VEGF signaling.” DOI: https://doi.org/10.18632/oncotarget.28355 Correspondence to: Cherie-Ann O. Nathan - cherieann.nathan@lsuhs.edu Keywords: TP53 mutant, HNSCC, angiogenesis, everolimus, mTOR About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Ligaments are dense fibrous connective tissues that are the attachments that hold bones to other bones. The most commonly injured or talked about is the ACL - Anterior Cruciate Ligament holding the femur to the tibia. Ligaments are formed by about 80% of the extracellular matrix and 20% of fibroblasts. This means the ligament is about 75% collagen, 1% elastin, and glycans. 90% of the collagen is type 1 and 10% is type III.In general, because of this makeup, they have a very poor natural regeneration capacity because of low cell density and nutrient/oxygen requirements. This is why often if complete failure happens replacement or reconstruction is necessary. In recent years, adding growth factors to treatment and healing has been shown to be effective in healing damaged ligaments. The process is usually described as four overlapping sequential stages: inflammatory stage, proliferation stage, remodeling stage, and maturation stage. If you can give support at each phase you can naturally heal and regenerate a ligament or tendon better. At the onset of injuries, hematomas form, and pro-inflammatory cytokines are produced by mast cells which recruit neutrophils, macrophages, and monocytes to the injury site. Angiogenesis is induced by the increased secretion of vascular endothelial growth factor (VEGF). ECM, primarily collagen III, is subsequently synthesized by the recruited fibroblasts at the injury site which is a hallmark of the proliferation stage. During the remodeling stage, ECM production and cell activities are decreased. Collagen III is replaced by collagen I and the collagen fibers start to organize along the direction of tendon stress. At the stage of maturation, the cross-linking of collagen fibrils increases and mature tendonous tissues form with their mechanical strength being gradually improved (Docheva et al., 2015).Inflammatory phase - 2 weeks - Need to get transportation to the area - walk the line - Not too much not too little. This is likely where we are trying to control inflammation and get blood flow to the area. PEMF - Improves vascularization - delivery of healing agents, proteins, and collagens and helps the synthesis of fibroblasts, and repair proteins, a faster healing process is achieved by helping prevent sports-related disabilities and chronic conditions.Cryotherapy - stimulates antiinflammatory responses once past the inflammatory phase and promotes regeneration. A study in 2016 by Ramos et al found that Cryotherapy has a unique ability to Reduces Inflammatory Response Without Altering the Muscle Regeneration Process and the Extracellular Matrix Remodeling of Rat Muscle. Something like an NSAID appears to do both. Intraligament medical needling can reduce mechanical properties and increase blood flow, inflammation, and production of collagen III and glycosaminoglycans compared to the control. Furthermore, mild needling properties returned to or exceeded pre-needling values at the 6-week time point. Clinical significance: Needling the rat supraspinatus tendon is a feasible technique that causes a transient healing responseShockwave for non-healing stimulates tissue inflammation that starts the healing process again. It can improve blood vessel formation, and blood flow as well as accelerated healing activationPeptides: A rat study conducted in 2010 found that BPC-157 lead to the healing of acute ligament injuries within rats.Collagen - needed for proliferation and remodeling Kaatsu - Episode 4 - improves growth factors without significant stress to the tendon or ligament. Remodeling 6 monthsContinue stressing and eccentric loading the joint or area with slow movements at least 3x/week and decreasing to 1x/week by 6 months but don't stop! Maturation - 2 yearsContinue to increase strength in the area and work on the stability, mobil

Dr. Ron Hunninghake, MD, Chief Medical Officer, and Dr. Lucas Tims, ND, FABNO, continue their discussion about the terrain approach to integrative oncology in this episode of the Real Health Podcast. Today's episode features two of the 10 terrains: inflammation and angiogenesis. Dr. Ron and Dr. Lucas explain how these two terrains can work in both good and harmful ways and what steps patients can take to help control them.

Did you know that your body can fight off diseases if you eat the right foods? Learn about the 5x5x5 framework and how you can feed your five defenses correctly. Join Corinna Bellizzi as she reviews Dr. William Li's bestselling book and course of the same name: Eat to Beat Disease: The New Science of How Your Body Can Heal Itself. Discover how your body heals itself with stem cells. Learn the best foods to eat while still having some cheat foods. This podcast episode marks the launch of a four-week series reflecting on Dr. William Li's New York Times bestseller, Eat To Beat Disease: The New Science of How Your Body Can Heal Itself and his online course of the same name. This series springboards from our interview with Dr. Li, which was episode #3. Relevant Past Episode:Interview with Dr.William Li: https://orlonutrition.com/blogs/podcast/eat-to-beat-disease-how-your-body-can-heal-itself-with-the-right-nutrition-with-dr-william-w-li-physician-and-nyt-bestselling-authorABOUT “EAT TO BEAT DISEASE”:Eat your way to better health with this New York Times bestseller on food's ability to help the body heal itself from cancer, dementia, and dozens of other avoidable diseases. Forget everything you think you know about your body and food and discover the new science of how the body heals itself. Learn how to identify the strategies and dosages for using food to transform your resilience and health in Eat to Beat Disease.We have radically underestimated our body's power to transform and restore our health. Pioneering physician-scientist, Dr. William Li, empowers readers by showing them the evidence behind over 200 health-boosting foods that can starve cancer, reduce your risk of dementia, and beat dozens of avoidable diseases. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems.The book's plan shows you how to integrate the foods you already love into any diet or health plan to activate your body's health defense systems-Angiogenesis, Regeneration, Microbiome, DNA Protection, and Immunity-to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions. https://drwilliamli.com/book-li/About Dr. William Li:William W. Li, MD, is an internationally renowned physician, scientist, and author of the New York Times bestseller “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.” His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease, and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC, and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic, and O Magazine. He is president and medical director of the Angiogenesis Foundation and is leading research into COVID-19.Sign up for his masterclass: https://drwilliamli.com/masterclass/Sign up for the paid course: https://eat-to-beat-disease.teachable.com/p/fullprice

Bio: William W. Li, MD, is an internationally renowned physician, scientist and author of the New York Times bestseller “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.” His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic and O Magazine. He is president and medical director of the Angiogenesis Foundation and is leading research into COVID-19.  ABOUT “EAT TO BEAT DISEASE”: Eat your way to better health with this New York Times bestseller on food's ability to help the body heal itself from cancer, dementia, and dozens of other avoidable diseases.  Forget everything you think you know about your body and food, and discover the new science of how the body heals itself. Learn how to identify the strategies and dosages for using food to transform your resilience and health in Eat to Beat Disease. We have radically underestimated our body's power to transform and restore our health. Pioneering physician scientist, Dr. William Li, empowers readers by showing them the evidence behind over 200 health-boosting foods that can starve cancer, reduce your risk of dementia, and beat dozens of avoidable diseases. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems. The book's plan shows you how to integrate the foods you already love into any diet or health plan to activate your body's health defense systems-Angiogenesis, Regeneration, Microbiome, DNA Protection, and Immunity-to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions.  https://drwilliamli.com/book-li/ ABOUT THE MASTERCLASS: Join world renowned scientist, physician, and New York Times bestselling author Dr. William Li as he shares his wealth of knowledge and research that has impacted more than 50 million lives. Dr. Li is a true pioneer in food as medicine and has discovered more than two hundred foods that activate the body's hardwired health defense systems: angiogenesis, regeneration, microbiome, DNA protection, and immunity. During this sixty minute free masterclass Dr. Li will break down each of the health defense systems to help you understand the basis of how they function and then share specific foods that you can use to activate each one. These are the same foods that Dr. Li has studied in detail to understand their abilities to combat and prevent things like cancer, cardiovascular disease.  https://drwilliamli.com/masterclass/ Miso Salad Dressing Makes enough for 2 salads Ingredients 2 Tbs. Miso 2 Tbs. Orange Juice 1 Tbs. minced ginger ½ t. minced garlic 1-½ Tbs. Rice Vinegar 1 t. tamari 1 Tbs. safflower oil 1 t. maple syrup 1 t. sesame oil 2 Tbs. Tahini 1 Tbs. Lemon Juice Add all ingredients into Mini Food Processor and process until smooth.

Join me and my good friend and guest Dr. William Li, physician, scientist, president and medical director of the Angiogenesis Foundation, and author of the New York Times Best-Seller Eat To Beat Disease: The New Science of How Your Body Can Heal Itself. His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic and O Magazine.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we talk about a study called, "Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue", published in 2019. Mentioned in this episode: Lipedema & Lymphedema Heart to Heart: A Collaborative 3-Day Learning Event Join us for three days full of immersive learning and discover cutting-edge holistic strategies that would help to drastically improve your health... and your quality of life. https://lipedema.captivate.fm/heart2heart (Join our Event!)

Plantar Fasciitis Shockwave TherapyPlantar Fasciitis New Treatment Using Shockwave TherapyShockwave treatment for Plantar Fasciitis, additionally called jogger's foot utilizes acoustic waves to separate mini attachments that develop in the muscle mass as well as ligaments of the reduced leg as well as foot. Attachments are quite like mark cells. When the mark cells appears it interrupts the typical matrix of muscle mass cells. This develops an excruciating problem additionally called Runner's Foot. Muscular tissue fibers indicated to relocate openly are currently limited as well as acquired. Over a long term time, the muscular tissue fibers end up being topsy-turvy including even more discomfort and also limitation of typical movement.Shockwave Plantar Fasciitis just how it functionsThe shockwave is acoustical in nature. The waveform developed sends out harmed Plantar Fasciitis muscle mass focused power to deal with severe as well as persistent foot and also heel discomfort triggered by Plantar Fasciitis. The discomfort is eased by numerous systems;Angiogenesis- the development of new members vesselsImproved Collagen manufacturing to reinforce connective cellsMobile Response to microtrauma creates raised ATP manufacturingLiquifies agonizing attachments in the fasciaUrges stem cell manufacturing (this has actually not been confirmed by FDA).What is Plantar Fasciitis?Plantar Fasciitis discomfort results from the swollen fascia under of the foot. It additionally entails numerous muscular tissues frequently called Tom, Dick, and also Harry. It generally impacts 1 out of 10 individuals eventually in their life. The cautious focus must be paid to the Tibialis Posterior, Flexor Hallicus Longus, and also Flexor Digitorum Longus. These are described as Tom, Dick, and also Harry muscle mass. This is an anacronym of the extensive provided names. These couple of muscular tissues link to nearly every bone in the foot. When these muscular tissues are attended to in enhancement to the plantar surface area of the foot, shockwave therapy for plantar fasciitis is a lot a lot more reliable.Why Core Health Darien for Plantar Fasciitis Shockwave?Dr. Mc Kay has actually examined the biomechanical marvel called the foot for over 20 years. He is among just a handful of chiropractic physicians learned to readjust the feet. By rearranging several of the 27 bones in the foot we can offer even more security to the longitudinal as well as median arcs of the foot. When dealing with Runner's Foot, the duty of muscle mass, as well as ligaments that add to plantar fasciitis, needs to be taken into consideration as well. By resolving the discomfort from a biomechanical strategy as well as incorporating that with shockwave treatment Core Health Darien can provide a quicker resolution of discomfort related to Plantar Fasciitis. We generally see outcomes within 8-12 therapies.

Shockwave Treatment New Method to Deal With Bad Back PainWhat is Shockwave Therapy?Shockwave Therapy is a therapy that is being made use of to speed up healing from bone and joint injuries. A fascinating note is that shockwave treatment in orthopedics initially obtained its begin as a therapy to break up kidney stones. Basically the exact same treatment is currently being utilized for an entire host of orthopedic conditions.You have persistent discomfort in your lower back. You attempt massage therapy, perhaps take a couple of Aleve which should care for it? When the discomfort comes to be extra significant do you take into consideration chiropractic treatment or physical treatment? When that does not function what do you do beside treat your pain in the back? Well, the bright side is you have an alternative. It is called Shockwave Therapy. Yes, it seems frightening however if you think of it there is something to it if you have persistent discomfort or an injury that will not recover.What Does ShockWave Treat?Achilles tendinitisPatellar tendonitisQuadriceps tendinitisSide epicondylitis/tennis elbow jointMedian epicondylitis/golfer's jointBiceps/triceps tendinitisPartial-thickness potter's wheel cuff splitsTrochanteric tendonitisPlantar fasciitisShin splintsMuscular tissue Spasmslower Back PainScientific Research Behind Shockwave TherapyShockwave Therapy is specified as a wave with a fast boost of stress within an extremely brief refactory time and afterwards having a progressive decline of stress with a little unfavorable stress stage.The shockwaves produced have countless peer-reviewed advantages with really couple of adverse effects.Discomfort decrease is most likely the greatest advantage of Shockwave Therapy. One method it reduces discomfort is by enhancing cell membrane layer passage by boosting the cell's leaks in the structure with ionic networks.Just how does Shockwave operate in the body?Nitric oxide manufacturing seems boosted by Shockwave Therapy. NO2 (Nitric Oxide) has the capacity to expand capillary. This permits even more blood circulation which permits the dissolution of toxic substances that collect in a hurt location. Extra blood quicker recovery. Angiogenesis is one more included advantage because the shockwaves boost your body to generate even more arteries in the therapy location. When treated with shockwave treatment permitting it to recover quicker, basically the hurt location has actually boosted metabolic rate.Is Shockwave Therapy Painful?When dealing with a hurt body component making use of Shockwave Therapy, there can be some pain. The shockwaves liquify lactic acid that often tends to swimming pool in muscle mass that are worn or wounded. The waves generated additionally permit broken cells to be gotten rid of by the blood vessels. There is a little discomfort yet we frequently see faster recovery times. Individuals with tennis elbow can begin to return to typical play in a couple of brief weeks. Somebody with a persistent lower back pain concern can begin extra hardcore physical treatment after a couple of sessions. Below ia an excellent way to consider shockwave treatment. After that Shockwave is a means to obtain over the obstacle to begin significant recovery, if the soft cells is not reacting.Is Shockwave Therapy covered by Insurance?Shockwave is not covered by insurance coverage. That might transform as insurer see it as a method to conserve

Did you know that your body can fight off diseases if you eat the right foods? Learn about the 5x5x5 framework and how you can feed your five defenses correctly. Join Corinna Bellizzi as she connects with Dr. William W. Li, MD, who is the bestselling author of Eat to Beat Disease. Discover how your body heals itself with stem cells. Learn the best foods to eat while still having some cheat foods. And, join his free masterclasses to learn more of what you'll learn today! About Guest:William W. Li, MD, is an internationally renowned physician, scientist, and author of the New York Times bestseller “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself.” His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases including cancer, diabetes, blindness, heart disease, and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC, and the Dr. Oz Show, and he has been featured in USA Today, Time Magazine, The Atlantic, and O Magazine. He is president and medical director of the Angiogenesis Foundation and is leading research into COVID-19. https://www.instagram.com/drwilliamli/ - Guest LinkedInhttps://drwilliamli.com - Guest Websitehttps://twitter.com/drwilliamli - Guest Twitterhttps://www.youtube.com/c/DrWilliamLi - Guest YouTubehttps://drwilliamli.com/masterclass/ - Guest Masterclass Show Notes:3:53 - Introduction6:04 - Why Write A Book?11:43 - Defining Health17:28 - Finding The Good Foods23:52 - The Study Of Steam Cells30:37 - The 5x5x5 Framework36:14 - Dr. William W. Li's Masterclass42:06 - What Did You Learn? ABOUT “EAT TO BEAT DISEASE”:Eat your way to better health with this New York Times bestseller on food's ability to help the body heal itself from cancer, dementia, and dozens of other avoidable diseases. Forget everything you think you know about your body and food and discover the new science of how the body heals itself. Learn how to identify the strategies and dosages for using food to transform your resilience and health in Eat to Beat Disease. We have radically underestimated our body's power to transform and restore our health. Pioneering physician-scientist, Dr. William Li, empowers readers by showing them the evidence behind over 200 health-boosting foods that can starve cancer, reduce your risk of dementia, and beat dozens of avoidable diseases. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems. The book's plan shows you how to integrate the foods you already love into any diet or health plan to activate your body's health defense systems-Angiogenesis, Regeneration, Microbiome, DNA Protection, and Immunity-to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions. https://drwilliamli.com/book-li/Love the show? Subscribe, rate, review, & share! https://caremorebebetter.com And join the Care More Be Better Community!YouTube: https://www.youtube.com/c/caremorebebetter Instagram: https://www.instagram.com/CareMore.BeBetter/ Facebook: https://www.facebook.com/CareMoreBeBetter LinkedIn: https://www.linkedin.com/company/care-more-be-better Twitter: https://twitter.com/caremorebebetter Clubhouse: https://www.clubhouse.com/club/care-more-be-better Support Care More. Be Better: A Social Impact + Sustainability PodcastCare More. Be Better. is not backed by any company. We answer only to our collective conscience. As a listener, reader, and subscriber you are part of this pod and this community and we are honored to have your support. If you can, please help finance the show: https://caremorebebetter.com/donate. Thank you, now and always, for your support as we get this thing started!

Dr. Kenta Nakamura joins us on this week's episode to discuss the history of stem cell research and how he plans to help lead it into the future.   His educational foundation in stem cell biology has intersected with an interventional clinical focus at UW Medicine to now lead a new clinical trial with human vascular endothelial growth factor (VEGF) to induce therapeutic angiogenesis (revascularization).  Episode topics:0:38 - Stem Cell Biology and Interventional Cardiology Career3:55 - Rocky Road of Stem Cell Therapies 9:25 - Thoughtful process of new clinical trials10:20 - Techniques and delivery of stem cells17:50 - Diagnostically measuring success21:43 - EXACT Clinical Trial - Refractory Angina 26:20 - Patient Criteria32:20 - Potential for Young Patients 37:29 - Motivation for Medicine39:47 - Advice for Translational Basic Science Careers43:28 - Outside of work45:50 - Referrals for Trialhttps://clinicaltrials.gov/ct2/show/NCT04125732@KentaMDnakamur@uw.edu

What is angiogenesis, and why should you care? Come listen in and find out! It is a common denominator of a lot of diseases of aging, and you can influence it to play nice within your body by the things you choose to eat. Little moment to moment choices in your life really do make a difference in your ability to live a long and healthy life.Great Book and website By Dr William Li: https://www.eattobeat.org/Grab These Free Resources:Guide to be ready before you get sick: https://healthcourage.ck.pageMP3 Audio of empowering questions to reprogram your subconscious: https://healthcourage.ck.page/questionsGuide to capitalize on the hormonal advantages of different phases of your menstrual cycle: https://healthcourage.ck.page/cycle

Aging-US published a Special Collection on Eye Disease which included "miR-106b suppresses pathological retinal angiogenesis" which reported that microRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Here, the authors show that expression of the miR-106b-25 cluster is negatively regulated by the unfolded protein response pathway of protein kinase RNA-like ER kinase in a mouse model of neovascular AMD. They demonstrate that therapeutic delivery of miR-106b to the retina with lentiviral vectors protects against aberrant retinal angiogenesis in two distinct mouse models of pathological retinal neovascularization. Dr. Przemyslaw Sapieha and Dr. Vincent De Guire said, "Age-related macular degeneration (AMD) is a common [1] and complex [2, 3] disease of aging and the leading cause of irreversible loss of sight in elderly people." Early forms of AMD are characterized by subretinal lipoproteinaceous deposits, local attrition of photoreceptors and loss of visual sensitivity. Late forms of AMD are defined by geographic atrophy and/or pathologic choroidal neovascularization characterized by vascular sprouting from the choriocapillaris into the neural retina or subretinal space. Sustained reduction in retinal VEGF levels can lead to neurotoxicity and degeneration of RPE-choriocapillaris in mouse models. Importantly, assessment by fundus photography and fundus fluorescein angiography of patients on anti-VEGF therapy showed accelerated development of geographic atrophy. These findings justify the need for continued exploration of novel therapeutic interventions. Given that several inflammatory and growth factors in addition to VEGF are associated with the pathogenesis of NV AMD, a multi-targeted approach is warranted. The authors previously elucidated a specific miRNA signature in the vitreous and plasma of patients with NV AMD and observed a disease-associated increase in miR-146a and a decrease in miR-106b and miR-152. Interestingly, within this cohort, they found that both vitreous- and plasma-based miR-146a/miR-106b ratios had greater than 90% discriminatory power for classification of patients with NV AMD with an area under the receiver operating characteristic curve of 0,977 in vitreous humour and 0,915 in plasma, suggesting potential for a blood-based diagnostic. The Sapieha/De Guire Research Team concluded in their Aging-US Research Output that there are efforts to devise therapeutics that simultaneously inhibit several factors involved in retinal vascular disease given the clinical success of compounds such as Aflibercept. miRNAs regulate translation of multiple genes and hence may be considered as multi-target inhibitors. Their potential to mitigate retinal disease will grow as comprehensive landscapes of miRNAs in health and disease are established. Preclinical studies are underway for mimics or inhibition of specific miRNAs. Full Text - https://www.aging-us.com/article/202404/text Correspondence to: Przemyslaw Sapieha email: mike.sapieha@umontreal.ca and Vincent De Guire email: vdeguire.hmr@ssss.gouv.qc.ca Keywords: age related macular degeneration, miR-106b, PERK, choroidal neovascularization, angiogenesis About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways. To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

Ashton and Madison discuss life happenings and then dive into the realms of True Crime and Angiogenesis!