Podcasts about Retinitis

Writer Andrew Leland talks with Phoebe about slowly losing his eyesight. He was diagnosed with the degenerative eye disease Retinitis pigmentosa when he was in high school. "It was like, 'I'm going out in the woods with my friends at night. And oddly enough, I'm bad at it.'" Andrew Leland's memoir, The Country of the Blind, A Memoir at the End of Sight, was a finalist for the Pulitzer Prize. Say hello on Twitter, Facebook, Instagram and TikTok. Sign up for our occasional newsletter, The Accomplice. Follow the show and review us on Apple Podcasts. Sign up for Criminal Plus to get behind-the-scenes bonus episodes of Criminal, ad-free listening of all of our shows, special merch deals, and more.  We also make This is Love and Phoebe Reads a Mystery. Artwork by Julienne Alexander. Check out our online shop. Episode transcripts are posted on our website. Learn more about your ad choices. Visit podcastchoices.com/adchoices

L.K. Bowen's debut novel FOR WORSE was named a "Best Debut Novel" by CrimeReads and follows a wife who is diagnosed with retinitis pigmentosa-a diagnoses that author Bowen also has received-and must survive at the hand of her abusive husband while simultaneously learning how to support herself on her own as she quickly loses her vision. Retinitis pigmentosa (RP) is a degenerative eye disease that affects over 2 million people worldwide, slowly causing people to lose their vision over time until they become fully blind. With Pulitzer Prize finalists such as The Country of the Blind by Andrew Leland putting focus on their life with retinitis pigmentosa (RP) and celebrities such as Jake Gyllenhaal opening up about legal blindness, there is no better time to champion books by authors and featuring characters who have disabilities as we look ahead to Disability Pride Month (July). Bowen's journey has been a long one: one full of introspection, resilience, and hope. This is a journey that echoes throughout the pages of her debut, with the added intrigue of a psychological thriller reminiscent of Audrey Hepburn's Wait Until Dark. Bowen wrote an emotionally wrought, yet hopeful essay for The Nerd Daily about her diagnosis, and recently appeared on a panel at ThrillerFest to discuss her debut novel and her work with RP. Compelled to bring light to her disease, Bowen became dedicated to putting a character like herself at the center of her novel, hoping her story (though fictional in many aspects) would reach people worldwide.Become a supporter of this podcast: https://www.spreaker.com/podcast/arroe-collins-unplugged-totally-uncut--994165/support.

What are blepharitis, conjunctivitis, meibomitis, iritis, uveitis, keratitis, retinitis, neuritis, and meningitis? Dr. Cremers reviews eye anatomy and diseases related to the different parts of the eye

L.K. Bowen's debut novel FOR WORSE was named a "Best Debut Novel" by CrimeReads and follows a wife who is diagnosed with retinitis pigmentosa-a diagnoses that author Bowen also has received-and must survive at the hand of her abusive husband while simultaneously learning how to support herself on her own as she quickly loses her vision. Retinitis pigmentosa (RP) is a degenerative eye disease that affects over 2 million people worldwide, slowly causing people to lose their vision over time until they become fully blind. With Pulitzer Prize finalists such as The Country of the Blind by Andrew Leland putting focus on their life with retinitis pigmentosa (RP) and celebrities such as Jake Gyllenhaal opening up about legal blindness, there is no better time to champion books by authors and featuring characters who have disabilities as we look ahead to Disability Pride Month (July). Bowen's journey has been a long one: one full of introspection, resilience, and hope. This is a journey that echoes throughout the pages of her debut, with the added intrigue of a psychological thriller reminiscent of Audrey Hepburn's Wait Until Dark. Bowen wrote an emotionally wrought, yet hopeful essay for The Nerd Daily about her diagnosis, and recently appeared on a panel at ThrillerFest to discuss her debut novel and her work with RP. Compelled to bring light to her disease, Bowen became dedicated to putting a character like herself at the center of her novel, hoping her story (though fictional in many aspects) would reach people worldwide.Become a supporter of this podcast: https://www.spreaker.com/podcast/arroe-collins-like-it-s-live--4113802/support.

Es una enfermedad ocular en la cual hay daño a la retina.

Retinitis pigmentosa or night blindness is a common psychosomatic problem. With the damage of retina, it damages the psychological state of the person. A person gets irritated and faces depression and other mental stress if he sees in the daytime and not at night. There are hundreds of genes which are responsible for night blindness. Those hundreds of genes are responsible for creating problems for blindness

Dr Shane is joined this week by EAGG colleague Dr Suzi. As well as science news, the team is joined by an eclectic mix of guests.Dr Michalis Hadjikakou Deakin University, discusses the complex dynamics and varied environmental impacts relating to food production. Olly Dove PhD Candidate University of Tasmania joins Dr Shane to discuss her work regarding foraging behaviour of sea birds.Ashleigh Geiger University of Adelaide & the SAHMRI gene editing program, shares insight into Retinitis pigmentosa (RP).The team also share some science news relating to the connection between marathons and myelin production, and Dr Shane provides an update regarding his most recent purchase (and love) of solar panels.

Für die meisten Menschen ist das Augenlicht das wichtigste Sinnesorgan. Allerdings kann das Sehvermögen durch chronische Augenerkrankungen bedroht sein, die viele Betroffene erst relativ spät bemerken. Ein Beispiel ist Retinitis pigmentosa, eine erbliche Netzhauterkrankung, die in Deutschland etwa 40.000 Menschen betrifft. Über die Hintergründe informiert im Gesundheits-Podcast Professor Ulrich Kellner, Facharzt für Augenheilkunde.

I veckans avsnitt. Att förlora synen kan vara något av människans värsta mardröm. Det är precis vad våran gäst Parima gjorde i tidig ålder. Hon fick diagnosen Retinitis pigmentosa (RP), nu är hon helt blind och vi tar reda på hur man tar sig vidare samtidigt som man fortsätter att vara positiv. Som vanligt skämtas det högt som lågt. Hoppas vi hörs!

On January 2, 2018, Michael learned he was going blind. Retinitis pigmentosa, he finds out, is genetic, with no known cure.Michael takes us through his deeply personal struggles of health, wealth, identity, and realization and how this led him to leave the corporate world behind for a new life chapter. His tale is an adventure, as he shares his transformative experience traveling across South America and Europe, writing, and forming relationships that have helped him rediscover his purpose. Today, he's found his way back to law. But family and life lessons now guide his WHY. Beyond the life story, we dive deep into the complex world of investment laws. With his extensive knowledge of securities law, Michael adds context and clarity to the new SEC limited partner guidelines. His keen insights into the SEC guidelines for real estate funds and the future of investment funds are both enlightening and thought-provoking. Finally, we touch on the fundamentals of investor education and the critical role trust plays in investment funds.Links Here:https://x.com/investing_law?s=20https://investoropportunitynetwork.com/Live free. Get Educated. Master Your Money. Subscribe to our Podcast here! https://investingstuffyoushouldknow.buzzsprout.comYoutube Videos now up as well! Subscribe here:https://www.youtube.com/channel/UC1kV60Yxx4ntgLqAwOCR1Pg

I had a whopping good time talking with Jennifer Armentrout about her new book, Fall of Ruin and Wrath, about ApollyCon - which is now almost 10 years old!We're going to talk about the behind the scenes of ApollyCon, her launch title for the new Bramble imprint of fantasy romance, plus she takes questions from some of you about disability advocacy, living with a visual impairment, and what changes she's seen in publishing.Music: Purple-planet.comYou can find Jennifer L. Armentrout on her website, on Instagram, and her Facebook Group JLAnders.We also mentioned:Retinosis PigmentosaThe Wilmer InstituteDragon DictationAnd, I request a humble favor: If you have a moment and your thumbs are not busy, would you be so kind as to leave a review for the show? I used to have a few on Apple Podcasts and now they are all gone! Apple is a mystery - but reviews help other folks find the show. So if you enjoy the podcast and you want to help me reach more nifty people, please review us. Thank you! Join our Patreon for complete mayhem, shenanigans, and more! Hosted on Acast. See acast.com/privacy for more information.

I had a whopping good time talking with Jennifer Armentrout about her new book, Fall of Ruin and Wrath, about ApollyCon - which is now almost 10 years old!We're going to talk about the behind the scenes of ApollyCon, her launch title for the new Bramble imprint of fantasy romance, plus she takes questions from some of you about disability advocacy, living with a visual impairment, and what changes she's seen in publishing.Music: Purple-planet.comYou can find Jennifer L. Armentrout on her website, on Instagram, and her Facebook Group JLAnders.We also mentioned:Retinosis PigmentosaThe Wilmer InstituteDragon DictationAnd, I request a humble favor: If you have a moment and your thumbs are not busy, would you be so kind as to leave a review for the show? I used to have a few on Apple Podcasts and now they are all gone! Apple is a mystery - but reviews help other folks find the show. So if you enjoy the podcast and you want to help me reach more nifty people, please review us. Thank you! Join our Patreon for complete mayhem, shenanigans, and more! Hosted on Acast. See acast.com/privacy for more information.

Jayanth Sridhar, MD, joins Sila Bal, MD, MPH, to discuss a case in which a 32-year-old man presented with floaters and decreased visual acuity for 2 weeks. Upon examination, imaging revealed peripheral whitening of the retina and opacification with areas of hemorrhages. Dr. Sridhar explains his approach in cases of infectious retinitis, outlines treatment strategies, and highlights the importance of working with an infectious disease uveitis specialist.

Bei der sogenannten Retinitis pigmentosa wird die Netzhaut schleichend zerstört – die Sehzellen können sich nicht regenerieren. Die Krankheit entsteht nur, wenn beide Elternteile den Gendefekt vererben. Was gentherapeutisch möglich ist, zeigt dieser Fall.

It would seem that Retinitis of Prematurity is a common theme amongst pre-mature newborns, not as often as it used to be though, but we have another guest with the same affliction. Kelly Hithe has been married since 2016, and she loves every minute of it. She is a proud wiccan and believes that the female Goddess provides for all, but I think her byline on her Facebook profile says it best, “I'm blind from birth and proud of it! I'm a happily married poly lesbian femme.” You can follow Kelly on her Facebook profile: https://www.facebook.com/kelly.bailey.1069 And you can subscribe to her channel here: https://www.youtube.com/@blinddykeblindgoddess/featured You should subscribe, if only to encourage her to make more videos and more posts on YouTube. Join Victor on Meet Me, on Whose Blind Life is it Anyway, every Monday, at 10:00 am Eastern, 7:00 am Pacific, and meet all the interesting people he meets. Victor is always looking for people to interview. His goal is to show the world that blindness and disabilities are not life ending, they are life altering, however, they can be more of an inconvenience, than anything else. If you would like to tell your story of living with a disability, you can contact Victor at: meetmeonblindlife@gmail.com Look for the Meet Me series on your favourite podcast app or device. Meet Me is now available in its own separate podcast, where ever you get your podcast, Apple, Google, Spotify, and even the Victor line of players from Humanware, you can find your favourite Whose Blind Life is it Anyway show, you just have to look for it. Music courtesy of Dora Speck

Heute haben wir Community-Mitglied und Pokemon-Progamer Mulay zu Gast. Dabei erzählt er uns von seiner unheilbaren Krankheit namens Retinitis pigmentosa. Eine sehr emotionale Geschichte, die besonders für einen Gamer ein hartes Schicksal bedeutet. Hört unbedingt mal rein!

Vi träffar Josefin Bergstrand och Roland Gustavsson från Nätverket för synsvaga som pratar om hur vardagen ser ut när man är synsvag. Vad är utmaningarna, finns det några fördelar? Hur är förhållandet till den vita käppen och brukar ni berätta att ni ser dåligt i nya sammanhang? Dessa och andra frågor diskuterar vi i det här avsnittet av Synpodden. Vi pratar även med andra vice ordförande Tiina Nummi Södergren om hur stor plats synsvagefrågorna får inom Synskadades Riksförbund och hur hon ser på strategierna i framtiden. Gå med i Nätverket för synsvaga För er som är intresserade av att veta mer om Nätverket för synsvaga eller gå med i det, finns mer information på denna länk. Ni kan även höra av er till Maria Sjötång på e-post maria.sjotang@srf.nu Synsimulator Synpodden testar Synsimulator, en app som Synskadades Riksförbund har utvecklat för att ge seende en möjlighet att få se hur personer med synnedsättning kan uppleva sin omvärld. Appen simulerar sex olika typer av synnedsättningar: makuladegeneration, Grå starr, Grön starr eller glaukom, diabetesretinopati, Retinitis pigmentosa eller RP och ålderssynthet. Appen går att ladda ner på App Store för Iphone och Google Play butik för Android och den kostar ingenting. Techpepp: mac vs pc Techpepp handlar om datasystem där vi jämför Mac och PC ur ett synrelaterat perspektiv, denna gång med fokus på att vara blind eller ha en grav synnedsättning. Ni hör Claudio Quitral, Madelene Fredriksson, Sandra Eriksson och Joakim Nömell. Programledare: Anna Bergholtz och Monica Walldén Ljudtekniker: Jan Dahlqvist Kontakta Synpodden Har du synpunkter, beröm, frågor eller önskemål på vad vi ska ta upp i Synpodden? Hör av dig på e-post Synpodden@srf.nu eller till vår telefonsvarare på 08-39 92 40.

In this episode, we review the high-yield topic of CMV Retinitis from the Opthalmology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.14.507903v1?rss=1 Authors: Francia, S., DiMarco, S., DiFrancesco, M. L., Ferrari, D. V., Shmal, D., Cavalli, A., Pertile, G., Attanasio, M., Maya-Vetencourt, J. F., Manfredi, G., Lanzani, G., Benfenati, F., Colombo, E. Abstract: Retinal degeneration is one of the prevalent causes of blindness worldwide, for which no effective treatment has yet been identified. Inorganic photovoltaic devices have been investigated for visual restoration in advanced stage Retinitis pigmentosa (RP), although lack of implant flexibility and foreign-object reactions have limited their application. Organic photoactive retinal prostheses may overcome these limitations, being biomimetic and tissue friendly. Inspired by organic photovoltaic strategies involving graphene, a hybrid retinal prosthesis was recently engineered consisting of a dual poly-3-hexylthiophene (P3HT) and graphene layer onto a flexible substrate. Here, this hybrid prosthesis was subretinally implanted in vivo in 5-month-old Royal College of Surgeons (RCS) rats, a rodent model of RP. Implanted dystrophic rats restored visual performances at both subcortical and cortical levels in response to light stimuli, in the absence of marked inflammatory responses. Moreover, the analysis of the physical-mechanical properties after prolonged permanence in the eye showed excellent biocompatibility and robustness of the device. Overall, the results demonstrate that graphene-enhanced organic photovoltaic devices can be suitably employed for the rescue of retinal dystrophies and supports the translation of the organic strategy into the medical practice. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

En este episodio te cuento la relación entre las dificultades en lectoescritura y la presencia de Retinitis Exudativa o Enfermedad de Coats. Si eres padre, madre o te dedicas a la Educación, no puedes seguir sin conocerlo! 1️⃣ SUSCRÍBETE A LA LISTA DE CORREO: https://juanjosemillan.es/landingpage/newsletter 2️⃣ SÍGUEME EN INSTAGRAM EN: https://www.instagram.com/webjjmiles ▶︎ AUDIOCURSOS GRATUITOS: https://www.juanjosemillan.es ▶︎ Si quieres saber más sobre quién soy, no dejes de ver mi CV en mi Web personal: http://blog.juanjosemillan.es/curriculum-juan-jose-millan

This week Sam was joined by Mr Steve Lash, Consultant Ophthalmologist at University Hospital Southampton NHS Trust. We take a squinted look at all the fundoscopy favourites that might come up in PACES and also covered the approach to a patient presenting with gradual visual loss. Steve also tackles sports psychology as his Quiz the Consultant topic! Timestamps:5:00 Approach to assessing the patient11:30 Cataracts20:20 Glaucoma27:20 ARMD31:20 Diabetic retinopathy38:05 Retinitis pigmentosa43:29 Quiz the Consultant> > Sign up for Pastest HERE! <

In this episode from the series “Key Decisions in HIV Care,” Cristina Mussini, MD, and William R. Short, MD, MPH, AAHIVS, discuss important considerations for ART with opportunistic infections, including: When to start ART with pneumocystis pneumonia including discussion of the ACTG 5164 study of immediate vs delayed ART with opportunistic infectionsEACS, DHHS, and IAS-USA guideline recommendations for starting ART in the setting of most opportunistic infectionsConsiderations for the administration of ART to patients who are unable to swallow or critically ill and intubatedTreatment of Kaposi sarcoma and considerations for starting ART to avoid drug–drug interactions with Kaposi sarcoma treatmentConsiderations for starting ART with cytomegalovirus and the risk for IRIS from cytomegalovirusDiscussion of treatment of cytomegalovirus and overlapping toxicities between its treatment and ARTWhen to start ART with cryptococcal meningitis and the data to support delayed treatment initiation with this particular opportunistic infectionEACS, DHHS, and IAS-USA guideline recommendations for starting ART in the setting of cryptococcal meningitis specificallyTreatment of cryptococcal meningitis and managing drug–drug interactions between ART and antifungal therapyPresenters:Cristina Mussini, MDHead of Department of Infectious Diseases and Tropical MedicineFull Professor of Infectious DiseasesInfectious Diseases Clinics University HospitalUniversity of Modena and Reggio EmiliaReggio Emilia, Italy William R. Short, MD, MPH, AAHIVSAssociate Professor of MedicineDivision of Infectious DiseasesDepartment of MedicinePerelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania Content based on an online CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP; and ViiV Healthcare.Follow along with the slides at:https://bit.ly/3uktrm1Link to full program:https://bit.ly/3q2DlGd

Gillian has an honest and insightful conversation with Nick Thorley.  Nick is co-founder and co-host of Nomad Podcast. He lives in Nottingham where he spent most of his 20's working as a Youth Minister for a group of Methodist churches. Since then he's been involved in fundraising for various international development charities. Nick loves to hang out with his kids, run very long distances, drink good coffee and meet up with friends. Themes and thoughts explored: Nick shares about who he is, including his experience of becoming blind from childhood until his late 20s. Retinitis pigmentosa (RP) The challenge of going through such a huge life experience in teenage years. The controlling and coping mechanisms Nick turned to or used including addictive behaviours of using pornography and gambling. Nick's sister intervening and suggesting therapy specific to addictive behaviour. Gillian and Nick discuss trauma and shame.  The embodied healing of running for recovery. Honest anger when things are hard is  healing.  Nick shares his experience of God now.  Shalom. Links: Nomad podcast www.nomadpodcast.co.uk GoHealth community https://gohealth.org.uk

In this week's episode, Carl is on the line with personal trainer, Kelsey Whirley, to discuss her Retinitis pigmentosa diagnosis, her love of CrossFit and how it changed her life

On today's show: Australian Winter Olympians win gold, silver and bronze, Kamilaroi kids campaign to bring home stolen trees, a roustabout impresses in the shearing shed, the world's oldest land animal celebrates a birthday, and an eight-year-old author's book is in demand. QUIZ QUESTIONS: 1. What is the Winter Olympics mascot's name? 2. Where were the stolen trees taken? 3. What is the name of Ashlea's eye condition? 4. What island does Jonathan live on? 5. What is the title of Dillon's next book? BONUS TRICKY QUESTION: What year was Jonathan photographed? ANSWERS: 1. Bing Dwen Dwen 2. Museums in Switzerland and Melbourne 3. Retinitis pigmentosa 4. St Helena 5. The Jacket-Eating Closet BONUS TRICKY ANSWER: 1882

On today's show: Australian Winter Olympians win gold, silver and bronze, Kamilaroi kids campaign to bring home stolen trees, a roustabout impresses in the shearing shed, the world's oldest land animal celebrates a birthday, and an eight-year-old author's book is in demand. QUIZ QUESTIONS: 1. What is the Winter Olympics mascot's name? 2. Where were the stolen trees taken? 3. What is the name of Ashlea's eye condition? 4. What island does Jonathan live on? 5. What is the title of Dillon's next book? BONUS TRICKY QUESTION: What year was Jonathan photographed? ANSWERS: 1. Bing Dwen Dwen 2. Museums in Switzerland and Melbourne 3. Retinitis pigmentosa 4. St Helena 5. The Jacket-Eating Closet BONUS TRICKY ANSWER: 1882

This week we chat with Glow who shares about her childhood trauma, and recent diagnosis of Retinitis pigmentosa - and how neither of those things are going to slow her down! Glow is on a mission to spread love and positivity!  You can find Glow on IG and Tiktok @glowsesh  Please consider downloading our episodes, sharing with friends, and leaving us a review!  You can find us online  IG @Ididnotsignupforthis.podcast Tiktok @Ididnotsignupforthis.pod Facebook @Ididnotsuft  Patreon.com/ididnotsignupforthis www.ididnotsignupforthis.ca   

Retinitis pigmentosa (RP) is a group of rare, genetic disorders that involve a breakdown and loss of cells in the retina. It is hereditary and often ends in total vision loss. Suffers are mostly diagnosed in their teens. Unusually my father was diagnosed with this condition at the age of 57. Now 70, my dad talks about his journey of slowly losing his sight and the impact his diagnoses has had on his life. We talk: fishing, retirement, sight loss, family, learning to walk with a white cane, guide dogs and the dangers of talking with your hands when you can't see waiters with drink trays beside you.Follow the podcast:Onemomentpleasepodcast.comIG:@onemomentpleasepodcastFB: One Moment Please 

Dr. Enzo Castiglione, Assistant Professor of Ophthalmology at the University of Chile, shares a detailed overview of Uveitis, including causes, symptoms, and treatment approaches. Dr. Castiglione also provides an overview of Autoimmune Retinitis, a rare disease in which the patient's own immune system attacks retinal proteins, leading to loss of vision.

In today's episode Pastor Cliff tells the story of growing up with Retinitis pigmentosa (RP) a group of rare, genetic disorders that involve a breakdown and loss of cells in the retina — which is the light-sensitive tissue that lines the back of the eye. Common symptoms include difficulty seeing at night and a loss…Read More

What do you do when you are told you are losing your sight? Victor Mifsud was in this position years ago and has since gone on a journey to save his sight. We talk about his condition, how it relates to other eye challenges, and concrete steps to improve eyesight. Victor has recently completed a feature-length documentary called My Neuroplastic Adventure. It shows his journeys from the cutting edge of neuroscience to the most ancient forms of tribal healing. He has interviewed doctors and scientists who are using technology and wisdom in equal measure. He is also the founder of the Vision Optimization Summit. Show Notes 0:30 Introduction to Victor Mifsud 1:55 Discovering a vision condition 6:20 Other difficulties and challenges in relation to Victor’s vision condition 9:00 What is neuroplasticity 11:30 What is your current eyesight condition? 14:15 What are some of the concrete things that worked for you? 15:30 How is red light helping our eyesight? 19:25 How to consume red light? 22:22 What other things can help people with their vision? 24:35 Exercises to relax your eyes 26:20 Using ketamine for eyesight 30:20 The importance of ancestral health history 31:45 What are peptides? 35:20 What is the Vision Optimization Summit 37:25 Victor’s final advice for living a happy, healthy, and meaningful life 38:00 Where can people find out more about you Connect with Victor Mifsud Website: https://visionoptimizationsummit.com/ Instagram: https://www.instagram.com/blindbiohacker/ Resources: Victor’s movie: https://www.imdb.com/title/tt7106284/ Retinitis pigmentosa: https://en.wikipedia.org/wiki/Retinitis_pigmentosa The Brain That Changes Itself: https://www.amazon.com/Brain-That-Changes-Itself-Frontiers/dp/0143113100 Ketamine Eyesight Study: https://clinicaltrials.gov/ct2/show/NCT02701933 When the Body Says No: https://www.amazon.com/When-Body-Says-Understanding-Stress-Disease/dp/0470923350 Red Light & Retintits Pigmentosa: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/ Peptides & Retinitis Pigmentosa: https://pubmed.ncbi.nlm.nih.gov/12195242/ CONNECT WITH MADS MISIAK FRIIS www.growthisland.com LinkedIn: https://www.linkedin.com/in/madsmfriis/ Instagram: https://www.instagram.com/madsmf/ Find the episode at:

Andrew McKeon, M,B., B.Ch., M.D., provides an overview of Mayo Clinic Laboratories' new paraneoplastic vision loss evaluation — a test that can help direct a cancer diagnosis and guide treatment. He reviews why this test was developed, when it should be ordered, and how the results can affect patient care.

El Dr. Frank Hammond, médico geneticista y profesor titular en la Escuela de Medicina de la Universidad Centro Occidental Lisandro Alvarado (UCLA), reporta en SALUDyTecnologia los resultados de un trabajo de investigación sobre ceguera infantil, realizado en la UCLA, que ha permitido conocer mejor las causas de algunas de las patologías más comunes y severas de ceguera en neonatos y menores de edad.--- ---Duración= 00:22:26.--- ---Imagen: hellomotherhood.com (Signs of Blindness in Newborns).--- ---Escuche también al Dr. Hammond en las entrevistas "Genética y medicina", "Plaguicidas y malformaciones congénitas" y "Progeria y esperanzas antienvejecimiento".Artículos relacionados:- Ceguera en niños de paises en desarrollo.- Prematuridad y ceguera.- Retinopatía de la prematuridad.- Problemas de la vista.- Ojo con la vista.- Patologías de la retina.- Glaucoma.- Retinitis pigmentosa: pérdida de visión por herencia.- Degeneración macular.- Vitamina A (retinol y carotenos).- Curando la ceguera con células madre.--- ---Encuentre más archivos de audio relacionados con salud en tecnologiahechapalabra.com.

Una visión clara y concisa para conocer los glaucoma en la voz de la médico oftalmologa Judith Cantillo, especialista en la materia, quien conversa con Peter T. para explicar como prevenir y tratar esta enfermedad, la principal causa de pérdida de visión en el mundo.Duración: 00:17:31Imagen: elnacional.cat ("Signos de que puedes estar padeciendo glaucoma")Conozca más sobre el glaucoma leyendo el articulo "Glaucoma" en TecnologiaHechaPalabra.com, o escuchando la entrevista "Conociendo al Glaucoma" con el Dr. Antonio Martinez.- - -Más sobre el glaucoma y otros problemas de la vista:- Glaucoma.- Problemas de la vista.- Conociendo al Glaucoma.- Retinitis pigmentosa: pérdida de visión por herencia.- Abuso de uso de tablets causa afecciones a la visión.- Doctor, veo mal de cerca (presbicia).- Patologías de la retina.- Todo sobre salud en TecnologiaHechaPalabra.

Michel Michaelides, MD, of UCL Institute of Ophthalmology; Moorfields Eye Hospital provides an overview of X-linked retinitis pigmentosa (XLRP), including its symptoms, common treatments, as well as a summary of the latest interim data from the MGT009 trial.

When former Mrs. America April Lufriu’s sister Melissa was diagnosed with Retinitis pigmentosa at just 19 years old, April poured her heart into advocating for her sister’s care. Hear how April's sister’s diagnosis prepared her – and didn’t – for her own and her children’s diagnoses and genetic testing journey two decades later.

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research. Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]

Fidelco Guide Dogs: A Clients Perspective with Bill DeMaio, Superintendent for Newington Parks and Rec. Hosted by Renee DiNino, Director of Community Affairs for iHeartMedia Connecticut.Bill shares his journey from the age of 30 when he was first diagnosed with retinitis pigmentosa, his first guide dog Isaac to present day and current guide dog Lyric.Retinitis pigmentosa(RP) is a group of rare, genetic disorders that involve a breakdown and loss of cells in the retina — which is the light sensitive tissue that lines the back of the eye. Common symptoms include difficulty seeing at night and a loss of side (peripheral) vision.

Diane is fully blind. So naturally, she has superhuman hearing, right? Nope. That's not how it works. Diane spent her entire life learning to navigate the world without vision to guide her and boy, did she figure it out. Diane suffers from Retinitis pigmentosa but that doesn't hold her back from being a tri-athlete, a former stand up comic, and currently the director of the CNIB Guide Dogs. We dive into the lack of accessibility, her love of cycling, and ALL things guide dogs!

Diane is fully blind. So naturally, she has superhuman hearing, right? Nope. That's not how it works. Diane spent her entire life learning to navigate the world without vision to guide her and boy, did she figure it out. Diane suffers from Retinitis pigmentosa but that doesn't hold her back from being a tri-athlete, a former stand up comic, and currently the director of the CNIB Guide Dogs. We dive into the lack of accessibility, her love of cycling, and ALL things guide dogs!  Ticket to our LIVE show - www.sickboypodcast.com/shows Support the podcast on Patreon - www.patreon.com/sickboy  Follow us on Instagram & Twitter - @sickboypodcast Thanks to Thisten for transcribing this episode - https://thisten.co/event/cbe4d

Diane is fully blind. So naturally, she has superhuman hearing, right? Nope. That's not how it works. Diane spent her entire life learning to navigate the world without vision to guide her and boy, did she figure it out. Diane suffers from Retinitis pigmentosa but that doesn't hold her back from being a tri-athlete, a former stand up comic, and currently the director of the CNIB Guide Dogs. We dive into the lack of accessibility, her love of cycling, and ALL things guide dogs!

Steve Tee is a speaker and Team Singapore athlete. He has won a bronze medal for the ASEAN Paragames, and will be competing in the 2021 Paralympic Games in Tandem Cycling. Due to an eye condition called Retinitis pigmentosa, he lost his sight in his early 20s. Yet, he refused to let his disability limit his abilities. He shares his powerful story of resilience in overcoming stigma and abuse, and gives tips on how to adapt to 'new norms' and changes. You can find him @Steve Tee on Facebook.

Episode 001 | Lance Johnson (Host - The See-Through Podcast) shares his story about life with Retinitis Pigmentosa as well as the format of the podcast. To learn more, visit: seethroughpod.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.13.092833v1?rss=1 Authors: Sanchez Cruz, A., Hernandez Pinto, A., Lillo, C., Isiegas, C., Marchena, M., Lizasoain, I., Bosch, F., de la Villa, P., Hernandez Sanchez, C., de la Rosa, E. J. Abstract: Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin receptor, a key controller of metabolism, also regulates neuronal survival and synaptic formation, maintenance, and activity. Indeed, deficient insulin receptor signaling has been implicated in several brain neurodegenerative pathologies. We present evidence linking impaired insulin receptor signaling with RP. We describe a selective decrease in the levels of the insulin receptor and its downstream effector phospho-S6 in retinal horizontal cell axons in the rd10 mouse model of RP, as well as aberrant synapses between rod photoreceptors and the postsynaptic terminals of horizontal and bipolar cells. A gene therapy strategy to induce sustained proinsulin production restored retinal insulin receptor signaling, by increasing S6 phosphorylation, without peripheral metabolic consequences. Moreover, proinsulin preserved photoreceptor synaptic connectivity and prolonged visual function in electroretinogram and optomotor tests. These findings support the therapeutic potential of proinsulin in RP. Copy rights belong to original authors. Visit the link for more info

Durante su educativa conversación con Peter T., el conocido médico español Antonio Martinez García; oftalmólogo especialista en glaucoma del Centro Oftalmología La Coruña, miembro de número en la Sociedad Española de Glaucoma, y experto en investigación experimental y clínica sobre glaucoma; explica como diagnosticar, tratar y prevenir al discapacitante glaucoma, la principal causa de pérdida de visión en el mundo.- - -Duración: 00:11:07.- - -Mas sobre el glaucoma y otros problemas de la vista:- Glaucoma.- Problemas de la vista.- Una mirada al glaucoma.- Retinitis pigmentosa: pérdida de visión por herencia.- Abuso de uso de tablets causa afecciones a la visión.- Doctor, veo mal de cerca (presbicia)- Patologías de la retina.- Todo sobre salud en TecnologiaHechaPalabra.- - -Imagen: Dr. Antonio Martinez

Today I describe what RP is and how it was diagnosed. Stay tuned to the end to hear how my son saved me from a bad accident,lol. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Anxiety. Sadness. Anger. Fear. Receiving a life-altering diagnosis is often accompanied by overwhelming emotions. In our first episode, you'll hear the stories of three guests who received the news of multiple sclerosis, retinitis pigmentosa, and Lyme disease with chronic pain, respectively. Our guests touch on how their diagnosis impacted everything from self-worth and identity, to relationships and new behavior. Later in this episode, you'll hear from a mental health professional who explains these responses, as well as the effectiveness of communication and supportive relationships during stressful times.

In Nicola’s 50th landmark podcast episode, she celebrates with her own personal journey in war-torn Beirut and how her ‘Yes I Can’ attitude strongly evolved under intense hypervigiliance situations. Nicola is joined by her very special guest this week, her Mom Pamela, who shares her life span over decades of rapid changes from the second world war, to the sixties and running a business, to fighting blindness, losing a business to fire, and much more. What kept her going? Find out this week as she and Nicola explore with candor and humor what it takes sometimes to keep us on track despite life’s challenges. Inspiring, honest to the bone, authentic and a delightful interaction between a mom and daughter. Links EMAIL: PamelaLowe@Melton.com WEBSITE: FightingBlindness.org/diseases/retinitis-pigmentosa Essential oils from Doterra

Living full out. How many of us can say we really live life this way and what does it really mean? Our guest this week is speaker, coach and radio show host Nancy Solari, and she joins us to talk about how we can develop an empowered, positive mindset and bring our lives into balance so we can live life to the fullest.Nancy was diagnosed at 16 years old with Retinitis pigmentosa, which left her legally blind. Faced with difficult life challenges and devastating heartbreak, she went on to have a successful career in broadcasting working for Good Morning America and Entertainment Tonight as well as being a  top-producing realtor in Southern California. Today, her Living Full Out platform helps others to find their voice, develop resiliency and courage and keep finding the silver lining in their lives.  Nancy is an amazing example of how you can live through the challenges in life and find balance, clarity, and meaning in your everyday.If you or someone you know is in an emergency, call 911 immediately. If you are in crisis or are experiencing difficult or suicidal thoughts, call the National Suicide Hotline at 1-800-273 TALK (8255). If you're uncomfortable talking on the phone, you can also text NAMI to 741-741 to be connected to a free, trained crisis counselor on the Crisis Text Line.More about Nancy:http://livingfullout.com (http://livingfullout.com)https://www.facebook.com/NancySolariLivingFullOut (https://www.facebook.com/NancySolariLivingFullOut)https://twitter.com/NancySolari (https://twitter.com/NancySolari)Brought to you by The Spark Summit:https://www.thesparksummit2019.com (https://www.thesparksummit2019.com)Like the show? Support us on Patreon:https://www.patreon.com/nocofm (https://www.patreon.com/nocofm)Hosted by Stephanie James. Produced by Chris Lanphear for NoCo FM.Hear more great podcasts at https://noco.fm (https://noco.fm)Follow the show:https://www.thesparkpod.com (https://www.thesparkpod.com)https://www.facebook.com/thesparkpod (https://www.facebook.com/thesparkpod)https://www.instagram.com/stephaniethespark/ (https://www.instagram.com/stephaniethespark/)Follow NoCo FM:https://twitter.com/nocofm (https://twitter.com/nocofm)https://www.instagram.com/nocofm (https://www.instagram.com/nocofm)https://www.facebook.com/nocofm (https://www.facebook.com/nocofm) Support this podcast

Living full out. How many of us can say we really live life this way and what does it really mean? Our guest this week is speaker, coach and radio show host Nancy Solari, and she joins us to talk about how we can develop an empowered, positive mindset and bring our lives into balance so we can live life to the fullest.Nancy was diagnosed at 16 years old with Retinitis pigmentosa, which left her legally blind. Faced with difficult life challenges and devastating heartbreak, she went on to have a successful career in broadcasting working for Good Morning America and Entertainment Tonight as well as being a  top-producing realtor in Southern California. Today, her Living Full Out platform helps others to find their voice, develop resiliency and courage and keep finding the silver lining in their lives.  Nancy is an amazing example of how you can live through the challenges in life and find balance, clarity, and meaning in your everyday.If you or someone you know is in an emergency, call 911 immediately. If you are in crisis or are experiencing difficult or suicidal thoughts, call the National Suicide Hotline at 1-800-273 TALK (8255). If you’re uncomfortable talking on the phone, you can also text NAMI to 741-741 to be connected to a free, trained crisis counselor on the Crisis Text Line.More about Nancy: https://www.facebook.com/nocofm (https://www.facebook.com/nocofm) Support this podcast

Shaini is a bean counter, baker, and public speaker with Fighting Blindness Canada. She says the kitchen can be therapeutic but macarons are not! We dish out a little baking wisdom, plus her journey with retinitis pigmentosa.

 - Shakespeare. On 04/08/2016, under a majestic old oak tree, I officiated the wedding for Bill & Bonnie.  Retinitis Pigmentosa has plagued Bill his whole life, slowly deteriorating his vision. There is no cure. As Shakespeare said, "Love looks not with the eyes but with the mind," I can tell you Bill & Bonnie have found a deep & beautiful love with one another.  Bonnie has had to increase her role as the seeing partner (driving, and so forth) & Bill has had to learn to accept this.  Their love, friendship, & raucous sense of humor is infectious, a beautiful thing to behold. In my own marriage, in my role as the one who needs care, Bill & Bonnie have so very much to teach me.  I am forever grateful for their example & their lessons.  

Kitty Barry shares her honest and uplifting reflections of motherhood (she has twin girls), her achievements and very raw experiences of life as a person with Retinitis Pigmentosa (RP). She chats about the book she's written - which is leaving a legacy for her twin girls.  Hope you enjoy this edition of the Stories Of You Podcast.   

Brian Fischler had me at his apartment in Queens, NY where talked about going blind and being blind from Retinitis Pigmentosa, guide dog school for his dog Nash, living alone, dating, doing stand up comedy, fundraising, having his own podcast and so much more!!! Please Listen, Please Share, Please Enjoy!!! Twitter @ejscott @EJPodcast Instagram @ejscott1106 My website www.ejscott.com charities to donate to www.crowdrise.com/7on7 RUNNING BLIND Documentary available on iTunes, amazon, google play

Laura is an artist, world traveler, and outdoor lover going blind bit by bit, day by day. She has an eye condition Retinitis Pigmentosa that’s been slowly taking her vision from her her whole life. In this episode, Branden talks with Laura about how she doesn’t let this condition get in the way of her art, adventure, or living a life of optimism and hope. -- @lauralawsonvisconti on Instagram & Twitter | lauralawsonvisconti.com @brandenharvey on Instagram, Twitter, Facebook & Snapchat | brandenharvey.com Find show notes at brandenharvey.com/podcast Get good news stories in your inbox every week at brandenharvey.com/goodnewsletter  

I det nya numret berättar vi om hopp för synskadade: skånska forskare hoppas snart vara i mål med genterapi mot vissa typer av den svåra ögonsjukdomen Retinitis pigmentosa. Skurupspolitikers oenighet om vem som ska driva färdtjänsten tas också upp. Ta även del aven en dietists vikttips så här i badsäsongens början!

Let's keep our eyes working for life! Tune in to Eve Plews, L.N.C, and get great tips to fighing macular degeneration, cataracts, retinitis pigmentosa, and even dry eye!

Stephen Euin Cobb (author and futurist) is today's speaker. Topics include: An update on Google Glass; Google's contest which will allow you to buy your own google glass for $1500 (your host has entered this contest); carbon nanotubes woven into conductive threads may replace copper for electrical wiring in aircraft and help wearable computers become woven into clothing; an impressive new antibacterial gel from IBM and the Institute of Bioengineering and Nanotechnology; and the first bionic eye to get FDA approval is an implanted artificial retina which gets its image wirelessly from an external camera. Also: your host offers his own little contest which piggybacks on Google's contest. Hosted by Stephen Euin Cobb, this is the February 27, 2013 episode of The Future And You. [Running time: 30 minutes]  Stephen Euin Cobb is an author, futurist, magazine writer and host of the award-winning podcast The Future And You. A contributing editor for Space and Time Magazine; he is also a regular contributor for Robot, H+, Grim Couture and Port Iris magazines; and he spent three years as a columnist and contributing editor for Jim Baen's Universe Magazine. He is an artist, essayist, game designer, transhumanist, and is on the Advisory Board of The Lifeboat Foundation. His novels include Bones Burnt Black, Plague at Redhook and Skinbrain.

Pastor Jeff grillo uses his amazing life story along with powerful Scriptures such as, Proverbs 23 to teach you the power your thoughtlife has. Listen, learn, encourage and inspire! This podcast will turn your life around.

After a tumultuous week that saw many deaths and widespread arson and rioting in Bangkok, we discuss the fallout from the army’s breakup of the redshirt protest site and what it means to Bangkok and the rest of Thailand. We also talk about how most of Bangkok continues as normal, even as a temporary curfew puts a major dent in Bangkok’s nightlife. In addition, we are very happy to be joined by Prae Sunantaraks – nicknamed Fluke – who was born with retinitis pigmentosa, a degenerative retinal disease that is slowly robbing her of her sight. She shares with us the details of The Little Light Project – a charity she started for blind children – and helps us understand how she remains so positive and upbeat even as her world becomes darker and darker – an outlook that many in Bangkok can appreciate these days. She also lets us in on the biggest mystery of all – how a visually-impaired person navigates the treacherous Bangkok sidewalks!

Eine große Gruppe genetisch vererbter Erblindungskrankheiten steht im Zusammenhang mit Mutation in Genen, die in Photorezeptoren exprimiert sind. Diese Mutationen führen nicht nur zu einer Beeinträchtigung des mutierten Proteins selbst, sondern auch zu einer Störung von funktionell nachgeschalteten Proteinnetzwerken. In der Folge ändern sich die Zusammensetzung von Multiproteinkomplexen sowie die Proteinlokalisation, was schwerwiegende physiologische Konsequenzen nach sich zieht. Alleine im lichtwahrnehmenden Molekül Rhodopsin sind mehr als hundert unterschiedliche Mutationen beschrieben worden, die vermutlich im Zusammenhang mit Retinitis pigmentosa, einer degenerativen Erkrankung der Retina, stehen (http://www.sph.uth.tmc.edu/RetNet/). In Saccharose-Dichte Gadienten Experimenten von Dr. Magdalena Swiatek-deLange, die dieser Studie vorangegangen sind, wurde Rhodopsin als Teil eines potentiellen Rhodopsin/Ras Homolog Gene Family, Member A (RhoA)/Ras-related C3 botulinum toxin substrate 1 (Rac1)/RhoKinase II (Rock II)/ Collapsin response mediator protein 2 (CRMP2) Signal-Multiproteinkomplexes in Außensegmenten von Stäbchen Photorezeptoren (ROS) identifiziert, welcher im Zuge dieser Studie bestätigt und eingehender untersucht wurde. Ein Zusammenhang zwischen einer Rhodopsin-vermittelten Degeneration von Photorezeptoren und der Regulation des Cytoskeletts durch die kleine GTPase Rac1, wurde von Chang und Kollegen (Chang and Ready, 2000) hergestellt. Sie haben gezeigt, dass die Expression von dominant-aktivem Rac1 in Rhodopsin-Null Mutanten von Drosophila die Rhabdomer Morphogenese erhalten kann. In Zellen fungiert Rac1 durch den Wechsel zwischen einem inaktiven, vorwiegend cytosolischen und einem aktiven, überwiegend membranassoziierten Zustand, als molekularer Schalter in der Signaltransduktion und vermittelt Signale von Membranrezeptoren an das Cytoskelett. Obwohl die Rolle von Rac1 bereits in einer großen Zahl unteerschiedlicher Zellen untersucht worden ist, ist seine Funktion in Photorezeptoren noch immer weitgehend ungeklärt. Die wenigen vorhanden Studien, in denen beispielsweise gezeigt wurde, dass Rac1 an der Fusion von Rhodpsintransportcarriern in Rana barlandieri (Deretic et al., 2004) oder auch an der lichtinduzierten Degeneration von murinen Photorezeptoren beteiligt ist (Belmonte et al., 2006), machen aber deutlich, dass Rac1 ein für die Funktion und Regulation von Photorezeptoren wichtiges Molekül ist. In dieser Studie wurde daher die Rolle von Rac1 in Photorezeptoren eingehender untersucht und ein Rac1-Interaktom in ROS, bestehend aus 22 Interaktoren, identifiziert. Von diesen 22 identifizierten Interaktoren sind fünf bereits als Interaktoren von Rac1 beschrieben worden, darunter CRMP2, einer der Hauptregulatoren von Polarität in neuronalen Zellen, sowie die cytoskelettalen Proteine Aktin ( and  und Tubulin ( and Unter den 17 neuen potentiellen Rac1 Interaktoren befindet sich das Aryl Hydrocarbon Receptor-Interacting Protein Like 1 (AIPL1), das im Zusammenhang mit Leberscher kongenitaler Amaurose (LCA) sowie mit retinalem Proteintransport steht (Sohocki et al., 2000), sowie eine Reihe von Proteinen, die Teil der Phototransduktionskaskade sind, wie die Untereinheit der 3´, 5´-cyclic-GMP Phosphodiesterase 6, Recoverin, Arrestin sowie die ,  und  Untereinheiten von Transducin. Rac1 verbindet damit die Lichtwahrnehmung durch Rhodopsin mit einer Regulation des Cytoskeletts und legt damit eine Interdependenz von Lichtwahrnehmung mit einer korrekten zellulären und funktionalen Struktur von Photorezeptoren nahe. In dieser Studie wurde nicht nur die Existenz des potentiellen Rhodopsin/RhoA/Rac1/Rock II/CRMP2 Multiproteinkomplexes in ROS bestätigt, sonder auch eine lichtabhängige Dynamik und Interaktion der einzelnen Komplexbestandteile beschrieben. In Übereinstimmung mit Daten aus verschiedenen Organismen ((Wieland et al., 1990), (Petrov et al., 1994), (Balasubramanian and Slepak, 2003)) konnte eine lichtabhängige Aktivierung von Rac1 in ROS von Schweinen nachgewiesen werden. Während lichtaktiviertes, GTP-gebundenes Rac1 überwiegend membranassoziiert vorliegt, konnte in dunkeladaptierten ROS insgesamt nur eine sehr geringe Menge an aktivem Rac1 detektiert werden. Des Weiteren wurden in dieser Studie auch deutliche Hinweise geliefert, die auf eine CRMP2 vermittelte Verbindung von Rac1 und RhoA assoziierten Signalwegen hinweisen, wohingegen die Kinase Rock II nur Teil des RhoA assoziierten Signalkomplexes zu sein scheint. Als Funktion von CRMP2 liegt daher eine Rolle als physiologischer Schalter nahe, der die Balance zwischen Rac1 und RhoA vermittelter Signaltransduktion koordiniert. Eine solche Funktion für CRMP2 wurde von Ariumura und Kollegen bereits für die Signaltransduktion in Neuronen vorgeschlagen (Arimura et al., 2000). Um die Signaltransduktion von CRMP2 in ROS eingehender untersuchen zu können, sind CRMP2 Antikörper unabdingbar, welche aber zu Beginn dieser Arbeit kommerziell nicht erhältlich waren. Daher war die Produktion und Charakterisierung von monoklonlalen CRMP2 spezifischen Antikörpern ein wichtiger Teil dieser Studie. Von den vier erhaltenen stabilen Linien monoklonaler, CRMP2 spezifischer Antikörper waren alle für den Einsatz im Western Blot sowie in der Immunohistochemie geeignet, aber nur ein Antikörper erwies sich auch als geeignet für die Immunopräzipitation von nativem CRMP2 aus primärem retinalen Gewebe. Dieser Antikörper stellt damit ein exzellentes Werkzeug für die weitere Charakterisierung der Funktion von CRMP2 in ROS dar. Drei Klassen von Proteinen regulieren die Aktivität von Rac1. Sie alle haben einen Einfluss auf den GTP/GDP-Austausch. Einer dieser Regulatoren ist der Rho GDP Dissociation Inhibitor (RhoGDI). Er kontrolliert die Interaktion von Rac1 mit weiteren regulatorischen Proteinen und Effektoren, sowie durch Interaktion mit dem Prenylrest von Rac1 das Pendeln zwischen Cytosol und Membran. Da aber der RhoGDI nicht in ROS nachgewiesen werden konnte (Balasubramanian and Slepak, 2003), legt dies den Schluss nahe, dass ein anderes Protein diese Funktion in ROS übernimmt. Das 17-kDa große Protein PDEdas lange Zeit als Untereinheit der retinalen cGMP Phosphodiesterase 6 aus Stäbchen galt, weist starke strukturelle Homologien zu RhoGDI auf. Es interagiert mit einer ganzen Reihe von prenylierten und unprenylierten Proteinen. Seine Fähigkeit, prenylierte Proteine von Zellmembranen zu lösen, erinnert stark an die Funktion, welche RhoGDI auf GTPasen der Rho Familie hat. Es wurde daher im Zuge dieser Studie untersucht, ob PDE in ROS GDI Funktion auf Rac1 ausübt. In dieser Arbeit konnte eine lichtabhängige Interaktion von Rac1 mit PDE in ROS von Schweinen nachgewiesen werden. Des Weiteren wurde gezeigt, dass aufgereinigtes PDE Rac1 von isolierten ROS Membranen lösen kann, eine Eigenschaft, die deutlich auf eine GDI-Funktion von PDE für Rac1 hinweist. Zudem wurde gezeigt, dass die Interaktion von Rac1 mit PDE mit einer lichtabhängigen Carboxylmethylierung von Rac1 in ROS korreliert, was ein Hinweis darauf sein kann, dass die die GDI Funktion von PDE durch die Methylierung von Rac1 reguliert wird. Alles in Allem zeigen diese Daten, das PDE für Rac1 in ROS die Funktion eines GDIs ausübt. In dieser Studie geben die identifizierten und mit Rac1 assoziierten Multiproteinkomplexe sowie deren lichtregulierte Dynamik einen deutlichen Hinweis darauf, dass Rac1 die Lichtwahrnehmung durch Rhodopsin mit Signalnetzwerken verbindet, die eine Rolle bei der strukturellen Integrität und Polarität von Photorezeptoren spielen. Dies deutet auf eine Abhängigkeit von Lichtwahrnehmung und funktioneller zellulärer Struktur hin. Mit der Bereitstellung von qualitativ sehr hochwertigen CRMP2 spezifischen Antikörpern liefert diese Studie zudem eine gute Basis für weiterführende Studien in diesem Forschungsfeld. Neben Rhodopsin assoziierten Komplexen stehen auch eine ganze Reihe von ciliären Komplexen in Zusammenhang mit degenerativen Erkrankungen der Retina. Im kürzlich entdeckten ciliären Protein Lebercilin (den Hollander et al., 2007) wurden Mutationen mit Leberscher kongenitaler Amaurose (LCA) in Verbindung gebracht, einer sehr schweren Form einer erblichen retinalen Dystrophie ((Kaplan et al., 1990), (Perrault et al., 1999)). Mit Hilfe von SF-TAP und LC/MS/MS Analysen konnten 24 Lebercilin Interaktoren in HEK Zellen identifiziert werden (den Hollander et al., 2007). Hier in dieser Studie wurden schließlich diese potentiellen Lebercilin Interaktoren auch in Photorezeptoren von Schweinen bestätigt (veröffentlicht in (den Hollander et al., 2007). Die identifizierten Interaktoren stellen mögliche Kandidaten für Gene für LCA und andere Ciliopathien dar und weisen Lebercilin als ein ciliär und mikrotubulär assoziiertes Protein in der Retina aus. Dies betont den Stellenwert, welche gestörte ciliäre Prozesse in der molekularen Pathogenese von LCA besitzen.