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Une audience particulièrement houleuse s'est tenue ce mardi 8 avril 2025 devant la Cour suprême israélienne, symbole des tensions politiques dans le pays. Les recours contre le limogeage du chef de l'Agence de la sécurité intérieure (Shin Bet), Ronen Bar, étaient examinés. Cette décision est dénoncée par ses détracteurs comme une dérive autocratique du pouvoir. Tout comme le vote à l'unanimité, fin mars, d'une motion de défiance inédite contre la procureure générale Gali Baharav-Miara. Dans le contexte de l'offensive à Gaza et de la colonisation en Cisjordanie, Israël constitue-t-il encore une démocratie ? Qu'est-ce qui pourrait stopper le Premier ministre Benyamin Netanyahu ?Pour en débattre Sylvaine Bulle, sociologue, chercheuse à l'École des hautes études en sciences sociales), autrice du livre Sociologie de Jérusalem (Éditions de La Découverte, 2020) Rina Bassist, correspondante de la radio israélienne à Paris et rédactrice au journal Al-Monitor Éric Danon, ambassadeur de France en Israël de 2019 à 2023À lire aussiIsraël: Benyamin Netanyahu mis en cause pour «conflit d'intérêts» pour le renvoi du chef du Shin Bet
Une audience particulièrement houleuse s'est tenue ce mardi 8 avril 2025 devant la Cour suprême israélienne, symbole des tensions politiques dans le pays. Les recours contre le limogeage du chef de l'Agence de la sécurité intérieure (Shin Bet), Ronen Bar, étaient examinés. Cette décision est dénoncée par ses détracteurs comme une dérive autocratique du pouvoir. Tout comme le vote à l'unanimité, fin mars, d'une motion de défiance inédite contre la procureure générale Gali Baharav-Miara. Dans le contexte de l'offensive à Gaza et de la colonisation en Cisjordanie, Israël constitue-t-il encore une démocratie ? Qu'est-ce qui pourrait stopper le Premier ministre Benyamin Netanyahu ?Pour en débattre Sylvaine Bulle, sociologue, chercheuse à l'École des hautes études en sciences sociales), autrice du livre Sociologie de Jérusalem (Éditions de La Découverte, 2020) Rina Bassist, correspondante de la radio israélienne à Paris et rédactrice au journal Al-Monitor Éric Danon, ambassadeur de France en Israël de 2019 à 2023À lire aussiIsraël: Benyamin Netanyahu mis en cause pour «conflit d'intérêts» pour le renvoi du chef du Shin Bet
Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.
Sam Danon, the managing partner at Hunton Andrews Kurth, talks about the importance of firm culture, what associates want out of a law firm and how building his litigation practice helped him establish credibility as a manager.
NEW YORK (STATI UNITI) (ITALPRESS) - “Tutti gli ostaggi devono tornare a casa e Hamas non deve restare a Gaza. Chiunque voglia una soluzione stabile per il Medio Oriente e per la pace deve sapere che Hamas non può restare in gioco. Siamo molto determinati su questo punto”. Lo ha detto ai microfoni dell'Italpress Danny Danon, ambasciatore di Israele alle Nazioni Unite, al Palazzo di Vetro. Danon è intervenuto al Consiglio di Sicurezza accompagnata dall'ex ostaggio Noa Argamani, che era stata rapita da Hamas nell'attacco del 7 ottobre 2023.xo9/sat/gsl (Video di Stefano Vaccara)
NEW YORK (STATI UNITI) (ITALPRESS) - “Tutti gli ostaggi devono tornare a casa e Hamas non deve restare a Gaza. Chiunque voglia una soluzione stabile per il Medio Oriente e per la pace deve sapere che Hamas non può restare in gioco. Siamo molto determinati su questo punto”. Lo ha detto ai microfoni dell'Italpress Danny Danon, ambasciatore di Israele alle Nazioni Unite, al Palazzo di Vetro. Danon è intervenuto al Consiglio di Sicurezza accompagnata dall'ex ostaggio Noa Argamani, che era stata rapita da Hamas nell'attacco del 7 ottobre 2023.xo9/sat/gsl (Video di Stefano Vaccara)
Tous les samedis et dimanches, dans Europe 1 Matin week-end, Alexandre Devecchio, rédacteur en chef du service débats du Figaro, livre son édito.
Tous les samedis et dimanches, dans Europe 1 Matin week-end, Alexandre Devecchio, rédacteur en chef du service débats du Figaro, livre son édito.
Die Israeliese ambassadeur na die VN, Danny Danon, sê hy kan glad nie verstaan waaroor daar ‘n bohaai is oor die verskuiwing van Palestyne uit Gaza sodat president Donald Trump dit kan omskep in die Riviera van die Midde-Ooste nie. Hy het met SkyNews gepraat en sê as mense wil trek moet hulle kan.
Summary: This week on The Genetics Podcast, Patrick is joined by Eric Adler, Chief Medical Officer and Head of Research at Lexeo Therapeutics and Professor of Medicine at University of California San Diego. Eric shares his experience with genetic cardiomyopathy and his work on gene therapy for Danon disease, drawing from both clinical and research perspectives. Additionally, he explores the evolution of the field and the broader challenges faced by cardiovascular patients. Show Notes: 0:00 Intro to The Genetics Podcast 01:00 Welcome to Eric and his efforts in cardiomyopathy at the bench and bedside 03:32 How modeling genetic diseases using pluripotent stem cells lead Eric to studying Danon disease 04:50 Pivoting from basic to translational research using adeno-associated viruses (AAV)-based gene therapy 07:58 Uncovering genetic cardiomyopathies that were misdiagnosed as idiopathic cardiomyopathy 09:55 Treatment, screening, and penetrance of Danon disease 12:30 Recent successes and remaining challenges in cardiovascular disease 19:47 Battling distrust in the medical profession 21:55 Preventative therapy using APOE2 for patients at risk of early Alzheimer's 25:15 Motivations behind and advantages of Eric's patient-centered approach to therapeutics 27:24 Balancing regulatory requirements for protocols versus patient needs 29:49 The importance of committed clinical partners for successful trial execution 36:08 Eric's passion for cooking and how he won a cooking competition 39:02 Closing remarks and Lexeo Therapeutics' aims for 2025 Find out more Lexeo Therapeutics (https://www.lexeotx.com/) Please consider rating and reviewing us on your chosen podcast listening platform! https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link
El veto de Israel a las operaciones de la agencia de la ONU para los refugiados palestinos (UNRWA) ha elevado la tensión y preocupación internacional. En octubre, el Parlamento israelí aprobó dos leyes que ordenaban la salida de esa agencia del territorio y de Jerusalén Este. En la práctica, la medida limita casi totalmente su operación en Gaza y Cisjordania, porque la ayuda solo entra con el aval de los israelíes. El martes 28 de enero, el embajador de Israel ante la ONU, Danny Danon, dio 48 horas a la agencia de la ONU para los refugiados palestinos (UNRWA) para evacuar sus centros en Jerusalén, en cumplimiento de una ley israelí que prohíbe al organismo prestar servicios en territorio israelí.Israel ha señalado a la UNRWA de mantener vínculos con el grupo palestino islamista Hamás."UNRWA deberá cesar sus operaciones y evacuar todos los locales en los que opera en Jerusalén, incluidas las propiedades situadas en Ma'alot Dafna (en Jerusalén Este) y Kfar Aqueb", dijo Danon en el marco de una sesión del Consejo de Seguridad, en el que se trató la situación de la agencia.El embajador citó la ley aprobada en octubre pasado que prohíbe a la UNRWA prestar servicios en territorio israelí, incluido el este de Jerusalén, donde viven más de 300.000 palestinos.Leer también¿Qué implicaciones tiene para los palestinos la prohibición de operaciones de la UNRWA en Israel?El inminente cese de operaciones de la UNRWA, este 30 de enero, ha disparado las alarmas en la región y de la comunidad internacional porque esta agencia, que cuenta con unos 30.000 empleados, se encarga de algunos servicios básicos, como los sanitarios y educativos, a los palestinos desplazados tras la creación del Estado de Israel y a sus descendientes, tanto en Gaza y Cisjordania como en Líbano, Siria y Jordania.Creada por la Asamblea General de las Naciones Unidas en 1949, la agencia de la ONU gestiona centros de salud y escuelas en la Franja de Gaza y Cisjordania. Proporciona refugio, alimentos y atención sanitaria y se considera la "columna vertebral" de la ayuda en Gaza.La situación llevó a convocar dos reuniones de urgencia del Consejo de Seguridad de la ONU para discutir el tema.Israel insiste en que la UNRWA se tiene que ir, mientras que la agencia reitera que esto atenta contra la obligación que tiene el Estado israelí con el Derecho Internacional y que solo la Asamblea General de Naciones Unidas puede decidir sobre su mandato.En tanto, el secretario general de la ONU, António Guterres, en una respuesta a Danon, advirtió el martes que Israel "no tiene derecho a ejercer poderes soberanos en ninguna parte del Territorio Palestino Ocupado, incluyendo el este de Jerusalén", y que su presencia allí es "ilegal" según el Corte Internacional de Justicia.Y añadió que no hay organización capaz de sustituir a la UNRWA, justo cuando está involucrada en la implementación del alto el fuego entre Israel y Hamás, que incluye la liberación de rehenes israelíes y la entrada de ayuda humanitaria en Gaza.Leer también¿Qué impacto tiene el retiro de la UNRWA en la atención humanitaria para Gaza y Jerusalén?¿Cómo afectará el cierre de UNRWA la entrega de ayuda humanitaria para los palestinos y el cese al fuego en Gaza? ¿Se trata de una decisión soberana de Israel que debe ser respetada? Para analizar el tema, participan en El Debate dos invitados.- Desde Barcelona, Cristina Muñoz, directora de Alianza por la Solidaridad, una ONG española que trabaja en Gaza.- Desde Costa Rica, Jesús Aguirre Gorgona, Máster en Derechos Humanos e Historia Judía y profesor de Política Global e Historia Hebrea en el Instituto Doctor Jaim Weizman.
L'ancien ambassadeur de France en Israël analyse le cessez-le-feu au Proche-Orient Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
On Friday's Mark Levin Show, President Biden can't leave the office quick enough. He now claims to have amended the Constitution. Biden announced that the Equal Rights Amendment is the “law of the land,” despite the Justice Department and the U.S. archivist saying the President could not ratify the Constitutional amendment. Biden is lawless then he lectures us about the rule of law. According to Democrats, you can do anything if it's in pursuit of the radical left agenda. Also, Ambassador Danny Danon calls in to discuss the Israel/Hamas ceasefire. This is not a peace agreement; Israel keeps the right to go into Gaza and finish off Hamas if necessary. Danon says they are determined to finish the job but will pause to get the hostages back. Later, Democrats keep telling us we have to fix our immigration laws, but they're not broken. We have very detailed immigration laws which work if they are enforced. The problem is Democrats lack of virtue and lack of execution - its intentional. It will be important to have a Governor in the DHS position – Kristi Noem will be fantastic. Afterward, a unanimous Supreme Court upheld the TikTok ban. It can still survive; it just needs new American ownership. We can't allow China to control Americans' data. Learn more about your ad choices. Visit podcastchoices.com/adchoices
For review:1. US CENTCOM Forces Strike Houthi Rebel Targets.On Dec. 30 and 31, US Navy ships and aircraft targeted a Houthi command and control facility and advanced conventional weapon (ACW) production and storage facilities that included missiles and uncrewed aerial vehicles (UAVs). 2. Israeli Ambassador (Danny Danon) to UN Gives Last Warning to Houthis. “To the Houthis, perhaps you have not been paying attention to what has happened to the Middle East over the past year. Well, allow me to remind you what has happened to Hamas, to Hezbollah, to Assad, to all those who have attempted to destroy us. Let this be your final warning,” Danon told the UN Security Council. 3. Latest in Israel - Hamas Hostage Negotiations. Israel & Hamas disagree on number of living Hostages to be released.4. Latest US Security Assistance Package to Ukraine worth $1.25 Billion.In addition, the US Treasury Department meanwhile announced the disbursement of $3.4 billion in direct budgetary support for Ukraine. 5. Greece to provide 24 x Sea Sparrow Missiles to Ukraine. The missiles are part of a broader defense package for Ukraine, including artillery shells, weaponry, and ammunition.6. Russian Foreign Minister (Sergei Lavrov) on President-elect Trump Peace proposal: “Of course, we are not satisfied with the proposals being voiced by representatives of the president-elect to postpone Ukrainian NATO membership for 20 years and to send to Ukraine a peacekeeping contingent of ‘British and European forces,'” Lavrov said. 7. Turkish Drone Maker Baykar purchases Italian aviation firm Piaggio Aerospace.
CardioNerds (Dr. Dan Ambinder and guest host, Dr. Pooja Prasad) join Dr. Donny Mattia from Phoenix Children's pediatric cardiology fellowship, Dr. Sri Nayak from the Mayo Clinic – Arizona adult cardiology fellowship, and Dr. Harrison VanDolah from the University of Arizona College of Medicine - Phoenix Med/Peds program for a sunrise hike of Piestewa Peak, followed by some coffee at Berdena's in Old Town Scottsdale (before the bachelorette parties arrive), then finally a stroll through the Phoenix Desert Botanical Gardens to discuss a thought-provoking case series full of clinical cardiology pearls. Expert commentary is provided by Dr. Tabitha Moe. Episode audio was edited by Dan Ambinder. They discuss the following case: Cardiology is consulted by the OB team for a 27-year-old female G1, now P1, who has just delivered a healthy baby boy at 34 weeks gestation after going into premature labor. She is experiencing shortness of breath and is found to have a significant past cardiac history, including atrial fibrillation and preexcitation, now with a pacemaker and intracardiac defibrillator. We review the differential diagnosis for peripartum cardiomyopathy (PPCM) and then combine findings from her infant son, who is seen by our pediatric cardiology colleagues and is found to have severe hypertrophic cardiomyopathy (HCM). Genetic testing for both ultimately reveals a LAMP2 mutation consistent with Danon Disease. The case discussion focuses on the differential diagnosis for PPCM, HCM, pearls on Danon Disease and other HCM “phenocopies,” and the importance of good history. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media Pearls Peripartum cardiomyopathy is a diagnosis of exclusion – we must exclude other possible etiologies of heart failure! Be on the lookout for features of non-sarcomeric HCM – as Dr. Michelle Kittleson said in Episode 166, “LVH plus” states. HCM with preexcitation, heart block, strong family history, or extracardiac symptoms such as peripheral neuropathy, myopathy, or cognitive impairment should be evaluated for infiltrative/inherited cardiomyopathies! As an X-linked dominant disorder, Danon disease will present differently in males vs females, with males having much more severe and earlier onset disease with extracardiac features. Making the diagnosis for genetic disorders such as Danon disease is important for getting the rest of family members tested as well as the opportunity for specialized treatments such as gene therapy Up to 5% of Danon disease cases may be due to copy number variants, which may be missed in genetic testing that does not do targeted deletion/duplication analysis!). Notes What is the differential diagnosis for peripartum cardiomyopathy? Peripartum cardiomyopathy is a diagnosis of exclusion – we must exclude other possible etiologies of heart failure! First, ensure that you are not missing an acute life-threatening etiology of acute decompensated heart failure – pulmonary embolism, amniotic fluid embolism, ACS, and SCAD should all be ruled out. Second, a careful history can identify underlying heart disease or risk factors for the development of heart failure, such as substance use, high-risk behaviors that put one at risk for HIV infection, and family history that suggests an inheritable cardiomyopathy. Lastly, a careful review of echocardiographic imaging may also identify underlying etiologies that warrant a change in management. Diagnosis of peripartum cardiomyopathy is important to consider as within 7 days of onset, patients may be eligible for treatment with bromocriptine – consider referring ...
Did you miss AHA 2024? Listen here to brief discussions of the latest research. Eric Rubin is the Editor-in-Chief of the Journal. Jane Leopold is a Deputy Editor of the Journal. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin, J. Leopold, and S. Morrissey. NEJM at AHA — Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease. N Engl J Med. DOI: 10.1056/NEJMe2414477.
Nouvel épisode de CONTACT avec l'ancien ambassadeur français en Israël, Éric Danon. Cour de tonnerre dans le monde politique français : le parquet réclame une peine de cinq ans de prison, une amende de 300 mille Euros et, surtout, cinq ans d'inéligibilité contre la patronne du RN, Marine Le Pen. La rencontre Bureau-Dumont avec Stéphan Bureau et Mario Dumont. Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr
Today, we're thrilled to bring you one of the most anticipated episodes of the year with Anthony Danon about the official announcement of Rerail, his brand-new $20M angel fund. You ofc already know Anthony as one of the hosts of our SuperAngel podcast series and part of the powerful duo behind Cocoa together with Carmen
Israeli Ambassador Danny Danon speech & UN Security Council meeting on the Middle EastIsraeli Ambassador to the United Nations, Danny Danon, addresses reporters ahead of the critical Security Council meeting on the Middle East, focusing on the Palestinian issue. Watch as Danon outlines Israel's stance and key topics expected to be discussed in this high-stakes session. Stay tuned for the Security Council meeting that follows, covering the region.Become a supporter of this podcast: https://www.spreaker.com/podcast/policy-and-rights--3339563/support.
20Angel is a series profiling European angel investors with the best Founder NPS. Episode 19 features Anthony Danon, Founder of Rerail, the latest Solo GP Fund to enter the European ecosytem. Anthony has spent 10 years in fintech as an operator, VC and angel, having done 35+ investments, with a portfolio including, Primer, TrueLayer, Wayflyer and many more. And on Monday 14th October, he announced Rerail I, an angel fund backed and supported by founders and operators. He invests $200k-$500k checks at pre-seed/seed into founders looking to utilize fintech as a strategic advantage, with a skew to Europe, but globally. The format for 20Angel is consistent across show, with questions including: What are some of the non-obvious things they look for when investing in a company? How they work with their Founders? What they think makes a great angel investor? Show links: https://www.rerail.vc/ https://www.linkedin.com/in/anthony-danon-3409099b/
Eric Danon a été ambassadeur de France en Israël de 2019 à 2023.Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Finance Minister Chrystia Freeland holds a news conference on Parliament Hill to provide her weekly economic update. She announces the payment amounts for the government's carbon rebates for small- and medium-sized businesses, which will deliver over $2.5 billion to about 600,000 businesses before the end of the year. She also announces the government has finalized the list of Chinese steel and aluminum products that will be subject to a 25 per cent surtax. Freeland is joined by ministers Jean-Yves Duclos (public services and procurement), Mary Ng (export promotion, international trade and economic development) and Rechie Valdez (small business).Vice President Harris in Augusta speaking with the Mayor about the hurricane damagePrestaken to support emergency response and recovery efforts in Georgia and other states throughout the southeast following Hurricane Helene. Israeli Ambassador Danny Danon today (1 Oct) told reporters in New York that Israel's response to a barrage of ballistic missiles launched by Iran on Israeli territory, “will be noticed” and “it will be painful.”Danon said, “the Islamic regime in Iran has now shown the world its true face. They are a terrorist state. For years they have armed terrorist and rogue states. They are responsible for the death of innocent civilians across the globe.”Until now, he said, “they have hidden behind proxies, but the mask has dropped. They have exposed themselves directly, launching hundreds of missiles into civilian areas. Their evil is now laid bare for all to see.”The Israeli diplomat vowed to “defend our people.” He said, “we will act. Iran will soon feel the consequences of their actions.”Danon expressed disappointment at Secretary-General António Guterres' message issued after the Iranian attacks calling for de-escalation and stressing the need for a ceasefire.He said, “we have no desire for war or escalation. But we cannot sit idly by when our civilians are being attacked in such manner.”Asked about specific plans for Israel's response, he said, “we will decide about when and how we will respond” an added, “the people of Iran who are watching us understand that it's not against the Iranian people. It's against the radical regime that dragged the Iranian people into this situation.”At the UNGA, Indonesia's Foreign Minister Retno Lestari Priansari Marsudi urged the international community to pressure Israel to return to a political path for a two-state solution, questioning Israel's commitment to peace.Become a supporter of this podcast: https://www.spreaker.com/podcast/policy-and-rights--3339563/support.
L'acteur, décédé à l'âge de 88 ans, sera inhumé ce samedi 24 août. Géraldine Danon sera présente aux obsèques.
Ecoutez RTL Matin avec Stéphane Boudsocq du 19 août 2024.
Géraldine Danon invitée de Stéphane Boudscoq et les nombreuses réactions à la disparition d'Alain Delon. Sans oublier les hommages rendus sur les chaînes de télévision.
Linda shared her amazing journey from being a Lawyer and hating it to now helping others understand the power of the mind. Linda is an RTT practitioner, life coach and trainer in the power of the mind and thoughts, she helps people get from where they are to where they want to be. She is very passionate about the workings of the subconscious mind and the brain as well as our ability, as human beings, to create the life that we want. And so while Linda creates the life of her dreams, she is helping others do the same.
Partir en expédition sur un voilier avec 4 enfants, dont un bébé de 6 mois, sans avoir jamais navigué… C'est ce qui résume la vie de Géraldine Danon. Dans cet épisode, Géraldine nous raconte ses expéditions à bord de son voilier Fleur Australe avec son mari Philippe Poupon et leurs enfants. Elle se confie sur sa philosophie de vie et sur le fait qu'il faut toujours faire un pas vers le changement avant que le changement n'arrive. Elle nous parle de ce qui lui plaît tant dans cette vie en mer, de cette notion du temps qui, en pleine mer, s'écoule comme dans un sablier. On parle de ses enfants qui ont vécu pendant plus de 13 ans en mer, de Florence Arthaud, son amie de toujours, dont elle vient de relater la vie dans le film "Flo" actuellement au cinéma. Un film qui m'a fait rêver, rire et pleurer, qui m'a surtout prouvé qu'avec passion et détermination, il est possible d'aller très loin. Je suis une grande admiratrice de Géraldine Danon, donc je suis très fière et émue de pouvoir partager ce riche échange avec vous.Pour découvrir les coulisses du podcast :https://www.instagram.com/milkandmamma_/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Dans cet extrait Géraldine Danon se confie sur sa philosophie de vie et sur le fait qu'il faut toujours faire un pas vers le changement avant que le changement n'arrive.Retrouvez l'épisode complet dimanche soir.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Ruth Danon grew up on the grounds of a mental hospital where her mother was a psychiatrist and many neighbors were European immigrants fleeing the devastation of World War 2. She forged a winding literary path, publishing four poetry collections and developing a style of teaching that treats writing as a studio art. She moved to Beacon in 2020 and now teaches privately and curates literary events such as the Spring Street Reading Series at Atlas Studios in Newburh and the Beacon Lit Fest, In this interview Ruth talks about her life and reads a cluster of poems from her new collection, “Turn up the Heat.” Photo credit: Meredith Heuer
Today, we're happy to be joined by Edwina Johnson, Head of Global at Alloy, leading company strategy to expand their product into key markets worldwide and launch a GTM team in the UK/EMEA.Previously Head of Global at Alloy, leading company strategy to expand our product into key markets worldwide and launch a GTM team in the UK/EMEA. Before that, COO at Alloy in NYC, taking the team from Seed to Series C and $1.55B valuation. Edwina is also an active angel investor, primarily through Ada Ventures, under the Economic Empowerment thesis, a mentor through Innovate UK's Women in Innovation program, and an Expert in Residence for Sie Ventures. We invite you to listen to this discussion below for some wonderful stories; besides the actionable advice, you can have a sneak peek at the below.Go to eu.vc for our core learnings and the full video interview
Hi Friends,This episode Jess and I discuss resolutions with friends of the podcast Leslie and Danon. They share their unique perspectives on New Year Resolutions. We all discuss if we agree with them, how effective are they and how we hold ourselves accountable. There were a few gems I personally got from this conversation. I hope you do as well. Enjoy.. Happy New Year!email: Bambooearringspod@gmail.comIG @ PodcastbambooearringsPhone 313 744 2087 (Leave a message)
As the events industry continues to evolve as fast as ever, the experience you deliver has never been more important... but we keep seeing the same people repeat the same mistakes of the past.That's why we decided to bring back one of our most popular episodes from last year, and share this conversation with Dan Gingiss - a keynote speaker and author of “The Experience Maker: How to Create Remarkable Experiences That Your Customers Can't Wait to Share.”After spending over two decades leading companies in both Customer Experience and Marketing, Dan let us in on their secret to success!He touched upon topics such as:- How event marketers should be reverse engineering the experiences they create- The WISER framework (and how it applies in events)- How to focus on experience and know what strategies to implement- And much much more!Don't miss out - listen in now for an insightful look at what it takes to make a successful experience that sticks and clicks.Connect with Dan: On his LinkedIn: https://www.linkedin.com/in/dangingiss/ Connect with Me:On my LinkedIn: https://www.linkedin.com/in/matt-kleinrock-9613b22b/ On my Company: https://rockwayexhibits.com/
CardioNerds cofounder Dr. Amit Goyal and cardiology fellows from the Cleveland Clinic (Drs. Alejandro Duran Crane, Gary Parizher, and Simrat Kaur) discuss the following case: A 61-year-old man presented with symptoms of heart failure and left ventricular hypertrophy. He was given a diagnosis of obstructive hypertrophic cardiomyopathy. He eventually underwent septal myectomy, mitral valve replacement, aortic aneurysm repair, and aortic valve replacement with findings of Fabry's disease on surgical pathology. The case discussion focuses on the differential diagnosis for LVH and covers Fabry disease as an HCM mimic. Expert commentary was provided by Dr. Angelika Ewrin. The episode audio was edited by student Dr. Diane Masket. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic Pearls - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic Left ventricular hypertrophy is a cardiac manifestation of several different systemic and cardiac processes, and its etiology should be clarified to avoid missed diagnosis and treatment opportunities. Fabry disease is a rare, X-linked inherited disease that can present cardiac and extra-cardiac manifestations, the former of which include hypertrophic cardiomyopathy, conduction defects, coronary artery disease, conduction abnormalities, arrhythmias, and heart failure. The diagnosis of Fabry disease includes measurement of alpha-galactosidase enzyme activity as well as genetic testing to evaluate for pathogenic variants or variants of unknown significance in the GLA gene. Family members of patients diagnosed with Fabry disease should be screened based on the inheritance pattern. Multimodality imaging can be helpful in the diagnosis of Fabry disease. Echocardiography can show left ventricular hypertrophy (LVH), reduced global strain, aortic and mitral valve thickening, and aortic root dilation with associated mild to moderate aortic regurgitation. Cardiac MRI can show hypertrophy of papillary muscles, mid-wall late gadolinium enhancement and low-native T1 signal. The treatment of Fabry disease involves a multi-disciplinary approach with geneticists, nephrologists, cardiologists, nephrologists, and primary care doctors. Enzyme replacement therapy can delay the progression of cardiac disease. Show Notes - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic What are the causes of left ventricular hypertrophy? LVH is extremely common. It is present in 15-20% of the general population, and is more common in Black individuals, the elderly, obese or hypertensive individuals, with most cases being secondary to hypertension and aortic valve stenosis. In general terms, it is helpful to divide the causes of LVH into three main groups: high afterload states, obstruction to LV ejection, and intrinsic myocardial problems. Increased afterload states include both primary and secondary hypertension and renal artery stenosis. Mechanical obstruction includes aortic stenosis, subaortic stenosis, and coarctation of the aorta. Lastly, several intrinsic problems of the myocardium can cause LV hypertrophy, such as athletic heart with physiological LVH, hypertrophic cardiomyopathy with or without outflow obstruction, and infiltrative or storage diseases such as cardiac amyloidosis, Fabry's disease, or Danon disease, among others. How does Fabry disease present? Fabry disease is present in all races and is an X-linked lysosomal storage disorder caused by pathogenic variants in the GLA gene that result in reduced alpha-galactosidase enzyme activity,
durée : 00:12:43 - L'invité d'un jour dans le monde - par : Fabienne Sintes - Le 7 octobre, l'Etat d'Israël entrait en guerre contre le Hamas à la suite d'attaques sur son sol. Deux mois après le début du conflit, nous faisons un état des lieux de la situation avec Éric Danon, ancien ambassadeur de France en Israël. - invités : Eric Danon - Eric Danon :
durée : 00:37:30 - Le 18/20 · Un jour dans le monde - par : Fabienne Sintes - Le 7 octobre, l'Etat d'Israël entrait en guerre contre le Hamas à la suite d'attaques sur son sol. Deux mois après le début du conflit, nous faisons un état des lieux de la situation avec Éric Danon, ancien ambassadeur de France en Israël. - invités : Eric Danon - Eric Danon : - réalisé par : Tristan Gratalon
durée : 00:37:30 - Le 18/20 · Un jour dans le monde - par : Fabienne Sintes - Le 7 octobre, l'Etat d'Israël entrait en guerre contre le Hamas à la suite d'attaques sur son sol. Deux mois après le début du conflit, nous faisons un état des lieux de la situation avec Éric Danon, ancien ambassadeur de France en Israël. - invités : Eric Danon - Eric Danon : - réalisé par : Tristan Gratalon
En pleine vague de biopics français (Tapie sur Netflix, Flo, et bientôt L'abbé Pierre), voici Flo, film consacré à la grande navigatrice Florence Arthaud, tragiquement disparue en 2015.C'est la scénariste et réalisatrice Géraldine Danon qui met en scène ce long métrage ambitieux, qui avait été présenté au Cinéma de la plage à Cannes en mai dernier. Connue comme "la petite fiancée de l'Atlantique", Flo raconte l'incroyable destin d'une femme farouchement libre qui décide de rejeter son milieu bourgeois et la vie qui lui avait été tracée, pour vivre pleinement ses rêves.Nous avons rencontré l'actrice Stéphane Caillard qui prête ses traits avec grand talent à Florence Arthaud.N'hésitez pas à partager, noter, commenter l'émission et à vous abonner à AlloCiné Podcasts.Tous nos épisodes sont à retrouver sur les plateformes de podcast, dont Deezer, Spotify, Apple Podcasts, Acast...Crédits :Journaliste : Brigitte BaronnetMontage : Chanelle Morvan
If you care about what you eat, you won't want to miss this conversation! Chris Van Tulleken is an infectious disease physician-scientist in the UK's National Health Service who has written a deeply researched masterpiece book on food—ULTRA-PROCESSED PEOPLE. It's not just about these synthetic and artificial UPF substances, that carry many health hazards, but also about our lifestyle and diet, challenging dogma about low carbs/glycemic index and the impact of exercise. Chris ate an 80% UPF diet for a month with extensive baseline and follow-up assessments including MRI brain scans. He has an identical twin brother who at times is 20 kg heavier than him. Why? What can be done to get limit pervasive UPF ingestion and its multitude of adverse effects on our health?For additional background to the book, here are some Figures and a Table from a recent BMJ piece by Mathilde Touvier and colleagues.Consumption of UPFs are highest in the USA and UKA Table summarizing some of the health hazards and magnitude of increased riskIn his book Chris gets into the evidence for risks that are much broader than cardio- metabolic, including cancer, dementia, inflammatory bowel disease, and other chronic conditions. A schematic for how UPFs increase the risk of cardiometabolic diseasesHere is the transcript of our conversation, unedited, with links to the audio podcast.Recorded October 20, 2023.Eric Topol (00:00):It's Eric Topol here with Ground Truths. And what a delight for me to welcome Chris van Tulleken, who has written a masterpiece. It's called Ultra-processed People, and it's actually much more beyond ultra-processed food as I learned. We're going to get into how it covers things like exercise, nutrition in general, all sorts of things. Welcome, Chris.Christoffer van Tulleken (00:27):It's such a pleasure to be here. And there's no one I would rather say that about my book than you, so that means a huge amount.Eric Topol (00:35):Well, I was kind of blown away, but I have to tell you, and it's probably going to affect my eating behavior and other things as we'll discuss for years to come. You're going to be stuck in my head. So what's interesting, before we get into the thick of it, your background, I mean as a molecular virologist turned into a person that devoted so much to food science, and you go through that in the book, how you basically got into rigorous reviews of papers and demand for high quality science and then somehow you migrated into this area. Maybe you could just give us a little bit of background on that.Christoffer van Tulleken (01:20):So I suppose it feels a tenuous thing. I'm an infectious diseases clinician, but the only people who get infections are disadvantaged people. For the most part, rich people well off people get cardiometabolic disease. And so I worked a lot in very low income settings in South Asia and Pakistan in the hills and in Central and West Africa. And the leading cause of death in the kids I was seeing in the infants was the marketing of food companies. So food, particularly formula, but also baby food was being made up with filthy water. And so these children were getting this triple jeopardy where they were having bugs, they were ingesting bugs from filthy water. Their parents were becoming poor because they couldn't afford the food and they lacked the immune system of breast milk in the very young. And so it sort of presented itself, although I was treating infections that the root of the problem was the food companies. And now my work has sort of expanded to understanding that poor diets has overtaken tobacco or it's depending on the number set you look at, but the Lancet Global health data shows that poor diets overtaken tobacco is the leading cause of early death globally. And so we need to start thinking about this problem in terms of the companies that cause it. So that's how I still treat patients with infections, but that was my route into being interested in what we call the commercial determinants of health.Eric Topol (02:52):Yeah, well you've really done it. I have 15 pages of highlights and notes that I got from the book and book. I mean, wow. But I guess the summary statement that somebody said to you during the course of the book, because you researched it heavily, not just through articles, but talking to experts that ultra-processed foods is not food, it's an industrial produced edible substance, and really it gets graphic with the bacteria that's slime and anthem gum and I mean all this stuff, I mean everywhere I look, I see. And I mean all these, I mean just amazing stuff. So before we get into the nitty gritty of some of these additives and synthetic crap, you did an experiment and with the great University College in London where you took I guess 80% of your diet for a month of up pfs. So can you tell us about that experiment, what it did for you, what you learned from it?Christoffer van Tulleken (04:04):Yeah, so it wasn't just a stunt for the book. I was the first patient in a big study that I'm now running. It's a clinical trial of ultra-processed food. And so I was a way of gathering data. I mean, you know how these things work, Eric. I was teaming up with my neuroscience colleagues to do MRI scans my metabolic colleagues instead of going, look, if we put patients on this diet, how would it all look and what should we be investigating if we do MRI scans, will we see anything? And so I ate various news outlets have portrayed this as kind of me heroically putting my body on the line for science. I ate a completely normal diet for many American adults. About one in five Americans eats the diet of 80% of their calories. It's a very typical diet for a British or an American teenager or young person.(04:52):So it wasn't arduous. And I was really looking forward to this diet because like most 45 year old doctors, I have started because of my marriage and my children, you start to eat in a rather healthy way. And this was amazing opportunity to go back to eating the garbage that I'd eaten as a teenager. I was going back to these foods I loved. So I guess there were kind of four things that happened. There were these three physical effects on my body. I gained a huge amount of weight and I wasn't force-feeding myself. And that really chimes with the epidemiological data that we have and from the clinical trial data run by Kevin Hall at the NIH, that this is food that gets around your body's evolved mechanisms that say, stop eating, you're full. Now the second thing that happened is we did some brain scans and I thought, well, the brain scan we're not going to see anything in a month of normal food.(05:43):So I switched from about 20% to 80% and we saw enormous changes in connectivity between the habit, automatic behavior bits at the back in the cerebellum and the reward addiction bits in the middle in the limbic system and associated regions. So that was very significant in me. And we did follow-up scans and those changes were robust and we really have no idea what is happening in children who are eating this stuff from birth to their brains, but it's concerning. And then the most intriguing thing was I ate a standard meal at the beginning of the diet and we measured my hormonal response to the food. And I think people are more and more familiar with some of these hormones because we've got drugs like semaglutide or wegovy that are interrupting these fullness or these hunger hormone pathways. And what we saw was that my hunger hormone response to a standard meal, my hunger hormones remain sky high at the end of the diet.(06:41):So this is food that is fiddling with your body's ability to say I'm done. But the most amazing thing was that this experience I had where the food became disgusting, there was this moment talking to a friend in Brazil called Fernanda Rabu. She's an incredible scientist, and she was the one who said, it's not food, Chris. It's an industrially produced edible substance. And I sat down that night to eat, I think it was a meal of fried chicken. And I was reading the ingredients and I could barely finish it. And so the invitation in my book is, please keep eating this food, read your ingredients lists and ask yourself why are you eating maltodextrin? What is it? Why are you eating xantham gum? What is diacetyl tartaric acid esters of monoglycerides of fatty acids? Why is that in your bread?Eric Topol (07:31):Yeah. Well, and then the other thing that the experiment brought out was the inflammatory response with the high C-reactive protein, fivefold leptin. So I mean, it really was extraordinary. Now the other thing that was fascinating is you have an identical twin. His name is, is it Xand?Christoffer van Tulleken (07:51):Zand, like Alexander,Eric Topol (07:53):JustChristoffer van Tulleken (07:53):The middle, full name's Alexander.Eric Topol (07:55):So spelled X, but okay, so he's an identical twin and he's up to 20 kilos heavier than you. So this helped you along with all the other research that you did in citations to understand the balance between genetics and environment with respect to how you gain weight. Is that right?Christoffer van Tulleken (08:16):That's right. So I have all the genetic risk factors for weight gain. And I know this because I've done studies with colleagues at the MRC unit at Cambridge, and I have all the polymorphisms, the little minor genetic changes that are very common. I have them all associated with weight. Now you can see I'm sitting here at the high end of healthy weight. I'm not thin, but I'm not. I'm just below overweight. And what protects me is my environment. And by that we mean my education, the amount of money I have, I have very little stress in my life. I have a supportive family. I have enough time to cook, I have a fridge, I have cutting boards, I have skills that I can do all that with. When my twin with this set of genetic risk factors moved to the states, he went to do a master's degree in Boston and he had a son in an unplanned way who's Julian is a much beloved member of the family, but it was very stressful.(09:15):What now? 13 years ago, and Zand kind of ate his problems, but the problems that he ate were ultra-processed food. So ultra-processed food, it's one of the ways in which the harms of poverty are expressed. So we know that people who live in stress and being poor is a significant source of stress. So it's disadvantaged. People generally smoke more, they drink more alcohol, they use gambling apps and they eat terrible food. And that is because of the environment they're in. It has nothing to do with their willpower or their choices. So part of the book is trying to reveal really that for many people, the food environment, the food that's available and they can afford is extremely violent to their bodies. And generally that's the environment of people who are already living with disadvantage.Eric Topol (10:06):Well, the data, which I wasn't fully familiar with, I have to say that you reviewed in the book, and then you may have seen in the British Medical Journal, there was a very good paper on ultra-processed food just published recently. I'm sure you know these folks. And not only does it review the point you made that 60% of the American diet and the UK diet is from ultra-processed food, but that all the analyses show 40% higher risk of type two diabetes, 35% risk of cardiovascular event, increased hypertension, 29% risk of all-cause mortality, 41% risk of abdominal obesity, metabolic syndrome, 81% higher risk. This isn't even yours. This is the review of all the literature, cardiovascular mortality, 50% higher risk. You mentioned the death from high U P F diet, 22% of all deaths. This is big. I mean, this is something I didn't realize. I knew it wasn't good, but I didn't realize the toll it was taking on the species. I mean, it's remarkable.Christoffer van Tulleken (11:17):It is in a sense, it's not enormously surprising. So the thing I think that is confusing a lot of people, there are two sort of sources of confusion. One is that the working definition that we all use is basically if something has an additive you don't find in a typical home kitchen, then it's an ultra-processed food. Now that has led a lot of people to go, well, the problem is the additives. Now, some of the additives, we think there's very good evidence they are causing harm. So the non-nutritive sweeteners, we had a huge paper come out and sell this summer. It's not referenced in the book, but the World Health Organization have written a position. And you may well know this literature better than me, but there's a growing concern that these products are definitely not better than sugar and they may predispose to metabolic disease and microbiome effects the emulsifier.(12:07):Again, we've got pretty good evidence that many of the synthetic emulsifies, and they are in everything. They're in your soda, your toothpaste, your bread, your mayonnaise. The emulsifiers are ubiquitous because they give a slimy mouthfeel that people like. So some of the additives are an issue, but the additives are just a proxy for food that is made with no regard for your health. And so a lot of the research I'm doing now is with economists. And so we're going to publish a paper in the next couple of months where one of the questions we've asked is, when it comes to the big transnational food corporations, is there good evidence within the corporations they care about human health? Because the companies that make this food say, we practice stakeholder capitalism, we care about the environment, we care about our farmers, we care about kids, people, our customers, we care about your health.(12:58):What we can show is that the way the companies spend their money is not to reinvest in those people, those stakeholders, they use it to buy shares back. So every quarter they do share buybacks to drive up equity value. We can show that when public health proposals reach the board or reach investors, institutional investors always vote down those public health proposals. And we have really good examples at Unilever, Pepsi and Dannon where CEOs have said, we want to make the food healthier and activist investors have fired the CEOs or fired the boards. So the companies are making the food with the purpose of generating money for institutional investors, usually pension funds. And so to me, it's not very surprising if you put yourself in the position of being a scientist at one of these companies or being a C E O and the market's saturated, we've all got enough food, you have to make food using the cheapest possible ingredients with the longest shelf life, and it has to be addictive or quasi addictive. That's the only way you can get us to buy more and more of it. And now that the states and the uk, Australia were saturated, they're starting to move very aggressively into south and Central America. I mean, they've largely done that, but now the focus is on West Africa, south Asia, east Asia, and Central Africa. So the purpose of the food, we call this system financialization, all the incentives in the system are financial. And so it's not surprising the food isn't very good for us.Eric Topol (14:31):And one thing I did like is that you did get into the companies involved here, and you also noted many times throughout the book about these scientists that said they didn't have any conflict and then turned out they had quite a lot of conflicts. And so one of the things I thought about while you mentioned about the transnational trans fats, trans fats were basically outlawed. And why can't we get, I think you touched on this in the chapter right before the end about we're just not going to be able to get these companies to change their ways, but why can't we get these U P Ss, particularly the ones that are most injurious? And by the way, you've proven that through three, not just the epidemiologic studies, which many people will argue diet logs are not so perfect, even though when it's in tens of thousands or hundreds of thousands of people. You mentioned, I wouldn't go back to the Kevin Hall experiments because he's really a noted researcher here in the US at NIH and also the biologic plausibility, which you've shown in spades throughout the book. But so with all this proof, why can't there be a path towards making these products, the ones that are the most implicated, illegal, and like the trans facts?Christoffer van Tulleken (15:56):So there are several answers to that. First of all, I guess my approach as an activist, and so I see in a kind of strange space because on the one hand I'm a scientist and I try and be fairly dispassionate. On the other hand, as you say, we now have very robust data. We've got more than a decade's worth. I mean, Kevin Hall sent a lovely tweet the other day, which I can unpack a bit, but this isn't argument basically between independent scientists and the industry and the industry are very, very skillful at mounting their arguments. So the argument of industry is, look, ultra-processed with the definition is wooly. It's not agreed on. These are largely observational studies. We need more randomized trials. The real problem with food, is it being high-fat, salt, sugar? And Kevin sent a brilliant tweet where it was in someone else where someone was going, look, why can't we just call it high-fat salt sugar?(16:52):What's processing got to do with anything? And Kevin said, well, look, no one has ever agreed on the definition of high-fat salt sugar. Whereas the definition of U P F is extremely widely agreed on, and we have now over a thousand studies linking it to negative health outcomes. So in terms of why we can't ban it, I guess my answer is I think it's politically extremely important not to frame it, not to frame things in terms of banning. If we want to see the gains that we got with smoking, my proposal is we need to regulate this food. We need to warden people, but we need to use the language of the political right and of the free market to get people on board. I want to increase everyone's choice in freedom. I don't want to take anywhere and cocoa pops or soda pop away.(17:36):It's fine if people want to buy that, but they should have a warning label on it and they should be able to buy fresh, affordable, healthy food. And what we know is that people like you and I, we will eat a bit of ultra-processed food, but broadly, people with resources don't eat this stuff. It's low income families that are forced to. So partly, I don't think we should be making it illegal, but the main reason is there is an enormous power. I mean, any one of these companies has the annual marketing budget that is maybe four or five times the entire World Health Organization operating budget each year. Okay, so we're talking 10 billion versus a couple of billion, and that's just for a company like Nestle or Danon or Coke. So the might of these corporations is overwhelming. And so the struggle will be very much as it was with tobacco.(18:30):And we have to be very careful how we sort of proceed and what we ask for. One of the issues that's going on at the moment is the definition of UPF at the moment is not suitable for legislation. So if we said, well, look, we are going to try and put a tax 10% tax on all UPF what will happen is the companies will have a lawsuit of every single additive. So they'll go, well, xantham gum is in kitchens actually, because we sell it in bags and people with celiac use it to bake at home. So then we have to have an exhausting discussion. So there's a group led by Barry Popkin and a number of other brilliant researchers who are creating a definition that it will include, I'm going to make this up, non-nutritive sweeteners, emulsifiers energy density and softness. And that will all with, we've got loads of randomized trials on all of that, and that will withstand the lawsuits. So it's about the technical approach has to be a very sophisticated one about resisting corporate power and the template has to be tobacco.Eric Topol (19:33):Yeah. Well, I think you've given a good response to those who would wonder, but the warning, as you know very well, far better than me, all we have on the foods are the nutrients of protein, carbohydrate, fat, saturated fat. There's nothing about warnings about the process. Ultra-processed content, which has to get fixed at some point in thatChristoffer van Tulleken (19:57):It has to, I mean, it is astound. What's going to happen is there are going to be lawsuits. So people are working on this and it's very hard to bring lawsuits around food, but one angle will be to focus on soda pop. So there should be a warning. And all the fizzy pop, it all contains phosphoric acid, which leeches minerals out of your bones, it dissolves your teeth, the sugar rots your teeth. And we will start to find communities that only drink one brand because there is a couple of very dominant brands, and they will be able to bring class action lawsuits about dental decay, and that's how it'll start. But in Argentina, in Chile, Columbia, they now on Cannes of cola do have big black hexagons. So it can be done. And I think the populations in the UK, obesity and diet related diseases reach such a crisis. People are so angry about this. And I think the people, the grassroots sentiment is I'm being gaslit by the people who sell my food. They've told me if I eat this, it'll help me lose weight. They've told me it will make me well, and it hasn't worked.Eric Topol (21:03):Yeah, well, that's for sure. Well, now I want to get into a couple of the things that shakes up the prevailing beliefs, the sacred cows, if you will. One of them is the burning calories with exercise. You really challenge that whole notion in the book, as I said, the book is not just about ultra-processed foods, which completely takes 'em apart, but you challenge the idea that you can work it off exercise, burn off these calories, and you have a pretty substantial part of the book that you really get into part help us understand because still today most people think, well, if I eat that such and such, I'll just exercise. I'll burn off those calories. What's the truth about that?Christoffer van Tulleken (21:56):So I wrote the book, I try to lay out the evidence for ultrapro food, but then you have to do some water battery because people always go, yeah, but isn't it because people who live with excess weight have low willpower, so I try and get rid of that. Or isn't it genetic? I can get rid of that. But a big argument is when it comes to the pandemic of obesity, surely it's because we spend all our lives on our phones, we sit around, we watch tv, and none of us work in heavy manufacturing anymore. So this idea was heavily promoted through a number of institutions, particularly something called the Global Energy Balance Network, and thousands of scientific papers in good robust peer reviewed journals. And some colleagues of mine at the London School of Hygiene and Tropical Medicines and Public health doctors did this incredible network analysis where they looked at the links between funding and all of these papers and all of the conferences that said, look, if you drink too much sugar or you eat too much chocolate, you just go for a run.(22:53):You burn off the calories, energy in energy out. Like it's simple. The entire network, and I really mean all of the papers, thousands of them were funded by the Coca-Cola Corporation. Now, in and of itself, that doesn't prove that it's a complete myth. But at the same time since the 1990s, there's been this real puzzling thing about our most sophisticated way of measuring energy expenditure using this technique called double labeled water. And there was this finding that no one could explain. It kept happening in all the studies in humans and in animals that people of the same size and shape and age and sex burn the same number of calories, whether they're subsistence farmers in Nigeria or secretarial workers in Chicago, whether they're hunter gatherers or office workers, everyone seems to burn the same 45 year old men who weigh 85 kilos like me. We can be hunter gatherers, we can be office-based doctors.(23:51):We burn the same number of calories. And a guy called Herman Ponsa pulled this together and he said, it seems like what is happening is that we have evolved to burn the same number of calories every day. Now, if you go for a run, you have to steal energy from other budgets. You can't violate the laws of physics. So if I burn 3000 calories today and I go for a 200 calorie run, I will take that 200 calories from my inflammation budget, from my anxiety budget, from my reproductive hormone budget. And that is why exercise is good for us. Now, what this doesn't mean is if you're cycling in the Tour de France, so you're an elite athlete or you're mountaineering, then you do burn more calories each day. And we've known that for a long time, but the kind of exercise that we all do each day, if we go to the gym a couple of times a week, that doesn't seem to affect our calorie expenditure. And the reason that, I mean, I'm an MD PhD, I feel I understand how the body works. I would say the reason I was unaware of that until I started writing the book and trying to figure out the piece of the puzzle I was missing is because of the Coca-Cola corporation. And there incredible network of edibles was network of literature that they funded.Eric Topol (25:01):Well, it shook me up because I was thinking all these years about, well, if I burned 500 calories, the other thing I thought about is I've had a knee operation replacement and I'm going to be immobilized and I'm going to get fat just because I can't exercise. And this was fascinating and you just reviewed it in a nutshell. It's really great for people to read that. Now, another one that you really took apart. So you and I both know Gary Taubes and I'm glad thatChristoffer van Tulleken (25:32):You had, and I want to say I love, I haven't spoken to him since the book, but I really, really love Gary. I think he's a brilliant guyEric Topol (25:40):And he has a new book that I blurbed about, not out yet on diabetes and all the lies about diabetes, but the book, he's been very influential as you know. And one of the things that he helped carry over the goal line and many others is this glycemic index and that the real reason we're fat is because we eat too much carbs and that it raises our insulin level and it makes us hungry. Basically, that's the simple dumbed down version and that he had been purporting that as the main driver of the obesity epidemic. You take issue with that, I would say, because you would say Uhuh maybe not so fast that UPFs are an important part of the story, and maybe it's not so simple as this glycemic index. Do I interpret that correctly?Christoffer van Tulleken (26:35):Yeah. So the sugar insulin debate is a long and exhausting one. And Gary, I would say, I mean he's a physicist by training and an incredible brain, and I think very few people have moved human nutrition further than Gary. Now, I would say the way he moved it is he got this incredible set of experiments funded, undertaken by Kevin Hall that really showed that there doesn't seem to be a particularly large difference between fat based diets or carb based diets in terms of how they affect your overall energy expenditure. And to some extent, it's not very interesting when we are talking about life out in the real world, there's a lab question about whether or not the carbohydrate insulin mechanism is really what's going on. And I would side kind of, I guess with Kevin Hall on that and said, I don't think the way you construct your diet in terms of its nutrients massively affects energy expenditure.(27:38):But in a sense, it's a bit moot because out in the real world, very few people are able to eat these ketogenic diets and stay on them. Some people are, a lot of people on the internet are, but kind of out in real life. We eat the food we're faced with. So I think sugar is very harmful in two ways. It rots teeth, and if you add sugar to food, you eat more of the food. And you can do this with any child at breakfast, you can give 'em a bowl of plain porridge and they won't eat much of it. You put two spoonfuls of sugar on it, they eat masses. Now, you haven't given them many more calories in terms of the sugar, but you've made something very appetite stimulating. So I think the crucial thing about all the research on U P F is it's all made adjustments for fat, salt, sugar, and fiber.(28:25):The big question for the epidemiologist has been are we sure this isn't just junk food that's high in fat, high in salt, high in sugar, and that's eaten by people who live in terrible housing and drink lots of alcohol and smoke lots. So the epidemiologists are very skillful at controlling for that. You can't control for everything. But what's consistent over all of the hundreds of prospective trials that we now have is that when you adjust for salt, fat, sugar, and fiber, not only does the effect remain in terms of statistical significance, it remains the same in terms of magnitude as well. And that backs up Kevin Hall's data where he had two, he randomized people to two equal diets nutritionally, same salt, fat, sugar, fiber, same deliciousness. People enjoyed the food the same amount. Both groups had as many calories as they could possibly eat, way more.(29:19):They have 5,000 calories a day, and yet the ones on the ultra-processed food, lost weight, sorry, on the unprocessed food, lost weight on the ultra-processed food gained weight. So I think what we may see is that when we go back and we redo some of the studies that link fat and sugar, and perhaps it may be salt, although I think salt is particularly in other ways, but when we do adjustments for ultra processing, we may see that the main driver of harm is when we encounter these molecules in formulations that we can't stop eating. So when we go and make the controls for ultra processing and we do the dietary analysis, we may see a dilution of the effect of fat and sugar.Eric Topol (30:02):So the people that swear, and there'll be many of them that listen or watch this, read this, they'll say, I went on a low carb diet and I lost all this weight. You would say, well, it wasn't just a low carb diet. There's a lot of other factors that come into play, including the fact that a lot of the carbs that you were eating are loaded with ups.Christoffer van Tulleken (30:27):Well, I think that's a great question. I would have two answers for those people. I'd say, well, that's great. And we know that many, if you eat any restrictive diet, so if you eat a low fat diet, a low carb diet, if you eat a diet based on avocados and breakfast cereal, many people will lose weight for some months. And particularly if you cut carbs out, food becomes much less palatable. Spaghetti bolognese is a lot less edible without the spaghetti. So we know that extreme keto diets, very low carb diets, they definitely work and they do help people lose weight. I don't think there's very good evidence that that's because of insulin suppression. I think it's because people eat fewer calories, because carbs make food delicious, and we just eat less of it.(31:18):And it may also be that when you cut out carbs, when you go on these diets, often you do switch away from industrially produced food that's very delicious, and you switch into, you become more conscious in other ways. So I think it definitely low carb diets help people lose weight. I'm not arguing that. I don't think it's to do with insulin, and I'm not sure they are. There's much evidence they're more effective than low fat diets, and there's very little evidence that anyone is any good at sticking to any diet for any period of time. Is that fair? I mean, I'm in your area now.Eric Topol (31:52):Yeah, no, no, that's a great explanation. A calorie is a calorie, and the diet, when you restrict it, it's going to have an effect at least on a short-term basis that is usually unsustainable over longer periods. I mean, this is, I think a shakeup. These are things in the book while you were directed towards the dissection of ultra-processed food and how our health is being adversely affected along the way. You take on a lot of these issues that people still, they are widely accepted. And that's what I especially enjoyed about the book is learning about your challenge of dogma. Some people when they watch this or listen to this, they're going to say, no, no, that can't be. And again, you're systematic. You quote the biologic plausibility studies, you quote randomized studies done by the likes of Kevin Hall. Well, let's talk about him in a moment. And then you get all these epidemiologic studies coming at everywhere. I mean, the hunt that you did on the research for this to find all these citations and review all them in itself was a tour to force.Christoffer van Tulleken (33:06):Whenever you open your mouth about food, you start an argument. And about 50% of the argument is the food industry who want the food industry wants us to believe the problem is with the nutrients because that's the thing they can fool around with. If sugar is the problem, they can take it out and put in the sweetness if that's the problem. They can put in xantham gum and gu gum and modified maize, starch and carrageenan. If salt's the problem, they'll put in potassium chloride. There's all kinds of stuff they can fool around with. They've been doing it since the early eighties and it hasn't worked. So the book is written in a kind of almost legalistic way. I mean, it has to be a legalistic, I mean, three teams of lawyers poured off the whole thing, but also I know I'm going to want people like you to read it, and I know it has to withstand your scrutiny.Eric Topol (33:57):It certainly has. I mean, what I love too is that in near one of the last chapters, you say, well, how are we going to get this on track? And you say The medical community, we as physicians caring for patients should be emphasizing this in our communication to patients. And I think that is one way a form of activism to take this on it, hopefully get it on track, largely been ignored. I mean, I think that the problem is because the food labels, even though people look at them, they don't read the fine print. That's where it shows up, if at all, and they're not familiar with the data incriminating all these things that shouldn't be in the food that are making it addictive and dangerous and whatnot. Yeah, I have to say, you have done a masterful job in reshaping my mind, which doesn't happen often when I read a book. I have to say it's just because what I admire is the depth of the citations backing it up. You're not a conspiracy theorist against the food industry. And I think you would be the first one to admit that Some people will say food science with air quotes because where's the science that a lot of the studies are garbage studies that are really questionableChristoffer van Tulleken (35:20):And the best science is done in industrial labs, and we don't have them too much access to it. I mean, I spoke, the most interesting community of people I spoke to for the book were people in the industry. They were all lovely. Many of them wouldn't be quoted, but they would explain how it was all done and behind closed doors, they all say, we know what we're doing. We know we are making addictive products. We've also got whistleblowers. And lots of people who have worked for engineer and people like Dana Small at Yale did lots of Pepsi funded research on the sweeteners. And when she published it all and said, look, I'm a bit worried about this, then Pepsi obviously stopped funding her. So yeah, I'm not a conspiracist and I'm also trying to make an argument. I'm not a neo-Marxist, not an anti-capitalist. We can imagine.(36:08):Part of the issue is in the states and in the uk, you are subsidizing the production of this food, and there is a whole industry and a whole set of businesses of people who make real food who could produce real food at a much more affordable cost. But instead what we do is we subsidize a very small number of agribusinesses to produce these commodity crops at the expense of the environment and our health, and then we pay less for the food in the shop, but we pay with our health insurance premiums and we pay with our environmental cost and we pay with our bodies as well. So this isn't really cheap food.Eric Topol (36:50):Well, that brings me to exacerbating preexisting inequities, which are far worse here in the US than many other countries, including yours. But the fact that there's these food deserts all over the place that the people can't get to, I mean the classification that a lot of people in the medical community are not familiar with the NOVA classification, the NOVA 1, the unprocessed or minimally processed food as opposed to what your book centered on the NOVA 4 ultra-processed food. But people in these desert food deserts can't get to the unprocessed NOVA 1 food and how can we get this righted because this is part of the problem is they're the ones at high risk and now their food that they're taking in is just making that even worse.Christoffer van Tulleken (37:47):I guess in my hierarchy of solutions, I have two things that need to be done before everything else. I believe that poverty is a political choice. There is huge amounts of money in both our countries and people. Children born into any household should be able to eat excellent, affordable food. So the number one thing is you have to fight poverty, that you don't need much redistribution. This isn't communism, it's not creeping socialism. It's just saying we could take a little bit of money out of the wealthiest corporations and individuals and lift a few people out of poverty. What we also know is when we do that, it's incredibly, so what's expensive is having an underclass of poor, unhealthy people in your society. So if you are a hawkish right-wing nationalist who wants a good football and a good military and low taxes, then for goodness sake don't have poor people living with terrible health problems.(38:42):It's ridiculously expensive. My interest is in social justice, I suppose, and I'm probably, I don't like to talk about my politics, but I'm a doctor working for the National Health Service. I treat patients with infections. So number one is poverty. The second thing you have to interrupt is the conflicts of interest. So in the UK, we had some headlines come out a couple of weeks ago, all the major papers published these headlines where five scientists had got together from something called the Science media center and said, look, ultra-processed foods are fine actually. And in fact, some of them are really healthy and you should eat brown bread and all this hysteria is nonsense. Now, when you looked at the five scientists, one of them had been the senior scientists at Nestle for 15 years. One of them was on the board of a multi-billion pound ultra-processed food company.(39:35):One of them had done research for the others and the institution, the science media center, very credible sounding. It's very, very popular in the UK with journalists. They always release press briefings. They're incredibly helpful. The Science media center is self-funded by Proctor and Gamble who make Pringles Nestle, who make Kit Katts and a consortium including Cargill and Coca-Cola. So none of the papers reported this apart from the Guardian did then run a brilliant story on the conflict. We have to see industry money as dirty. No one would accept the British Lung Foundation and their spokespeople taking money from Philip Morris and British American tobacco. We would all go, that's crazy. Well, the food industry are now doing this incredibly brilliant thing, which is exactly what the tobacco industry did, where they're doing this manufacturing doubt. So a lot of my time is spent trying to very carefully frame arguments in a way that is shored up against anyone thinking I'm trying to ban anything or take their fun away.Eric Topol (40:37):I love it. Have I missed anything that I should have asked you about? Because we've covered a lot of ground and I can't do justice to this book because it's a phenomenal book, and I hope that the people that are not just those who are worried about their own nutrition, but their loved ones, their patients, whatever, will get into this because you've got a lot of work here to offer to get people up to speed, educated about the problem. But is there anything else you can think of that you want to highlight?Christoffer van Tulleken (41:12):I think the only thing I try and underline, and you are always very skillful at this, but it's that I think one of the main harms for people who live with obesity and who live with diet related disease is stigma, particularly from our profession. We treat patients who live with obesity terribly badly. And the book, I hope, if it does, nothing else should try and show to any physician who reads it or any parent that when someone is living with any diet related disease, it really is not them. It is the food. We are saturated in products that we have, good evidence are addictive. They are all around us. And at the moment, our patients who are trying to lose weight, it's like them trying to quit smoking in the 1960s, you and I would be doing this interview smoking away, there'd be clouds of smoke everywhere my kids would be smoking. So that's the environment we're in. And I think if we can give people a break and try and try and not judge them and try and critique the system, that is the outcome that we need.Eric Topol (42:14):And here we are. We've got the GLP-1 drugs like Mounjaro and with Wegovy chasing the epidemic. And so we're using drugs, injectable drugs right now to chase something that is partly food mediated, I would say. And the other thingChristoffer van Tulleken (42:31):About those drugs that's so interesting is if you take the drug and you don't gain weight, but you continue eating the foods that drive other diseases, the effects where ultra-processed food seems to be associated with cancer, all cause mortality, dementia, anxiety, depression, cardiometabolic disease, that's when you adjust for obesity. So you don't have to gain the weight to have those effects. It's not that those things are caused by the weight gain, they're independently caused. And so you can be taking your Wegovy and you'll still have an elevated risk of cancer unless you change your diet. So these drugs are not going to get us out of the hole. They're going to be wonderful for some people who need to lose weight, but they're terribly expensive and they should not let the government off the hook of making sure that good food is available.Eric Topol (43:19):And then the other thing I wonder about, as you know, I work a lot in the AI space and I'm thinking these companies are going to increasingly use AI to make their addiction levels even higher because this is the way to understand how the proteins of the three D structures will bind better to parts of our receptors in our brain and whatnot. I mean, I'm worried that this could even get worse from these companies.Christoffer van Tulleken (43:50):It will definitely get worse. So I mean, the point you make is really important at the moment when we think about food addiction and was this brilliant paper was published the other day by Gerhart and Dili Santonio, two wonderful scientists, and they were drawing together a lot of different research showing that the food is addictive, whether you're scanning people or gathering psychiatric data. But the moment, the way we think about addiction is kind of these sugar fat ratios, but clearly it's so much more complex that when we add flavor acid, bitterness, sourness, all of these molecules, plus is exactly as you say, the food matrix, the texture, the smoothness, the fattiness, the packaging, the font animal that's there, the colors, all of it contributes to a sort of gestalt around each product that drives addiction. So yes, there is no question that the academic community has a very primitive understanding of how this food is driving excess consumption.(44:48):I suspect the companies know more, but mainly they've just been iterating it for decades. I mean, all the companies said the same thing to me. When they test food, they put it through a tasting panel, and one of the things they measure is how much do people eat and how quickly do they eat it? And if you've got two boxes of cereal, the one that people eat the quickest and the fastest is the one that goes on the shelf. And they've been doing this. You and I ate the same cereals as children, as my kids do. They've been perfecting them for five decades. And so it's not surprising that every single aspect of those cereals or the breads or the spreads, it's all dialed up to 11, whether it's the emulsifier, which one do you use? How much salt, the smoothness, glucose syrup, is it too sweet? A little bit more fructose? Our understanding is so primitive.Eric Topol (45:41):Well, your dissection of it is as comprehensive I could ever imagine from the speed that we eat to the texture and the softness and all the other things you just mentioned. So I want to congratulate you. This is, as I said at the top a masterpiece, and I'm really, we should be indebted to you for pulling it all together, and I look forward to further discussions with you because every time I eat now, I'm going to be thinking of you.Christoffer van Tulleken (46:10):I love it. I mean, Eric, I cannot tell you, I'm a long time admirer, so it is. Anyway, I'm not going to fanboy too much, but I can't tell you I'm deeply touched and very moved, and so I really appreciate you saying that.Eric Topol (46:22):Well, for you to volunteer to help on a Friday night late in the UK to do this, I'm indebted as well. So thanks so much, Chris. I look forward to talking to you much more in the future and really appreciate your joining today.Christoffer van Tulleken (46:36):I hope we'll speak again.Thanks for listening and subscribing to Ground Truths! Please share with your network if you found it useful. Thank you for reading Ground Truths. This post is public so feel free to share it. Get full access to Ground Truths at erictopol.substack.com/subscribe
Today we are happy to welcome Ambre Soubiran. A mathematician by training, she has spent the first decade of her career working in the equity derivatives and capital markets industry. Amber has a passion for world-changing technologies and is personally interested and invested in the digital assets space since 2012. Amber is currently the CEO of Kaiko, the reference market data provider in the blockchain industry. Kaiko is a global organisation with offices in NYC, London, Paris, and Singapore, servicing top-tier financial institutions and enterprises with reliable and actionable financial data.
Commentary by Dr. Valentin Fuster
Today, we're happy to feature Francesco Simoneschi, Co-Founder and CEO at TrueLayer and angel with 60+ investments.In this episode, Francesco dives deep into his experience going from VC to angel investing, the nuances of angel investing, shedding light on some counterintuitive lessons he's learned along the way. He delves into the importance of trusting your instincts when assessing early-stage startups and why sometimes, early traction can be a red flag.Francesco also shares his strategies for making international investments and the value of building a network of trusted insiders in unfamiliar territories. Plus, he reflects on the soft skills and leadership qualities that he wishes he had focused on earlier in his career.Jump to the parts that matter most to you and watch our core highlights below
Today, we're happy to welcome you to Charlie Delingpole, founder of ComplyAdvantage, an AI-driven financial crime risk and detection technology powered by Complydata. They have raised $100m from Index Ventures, Balderton Capital, OTPP and Goldman Sachs with global hubs in London, New York, and Singapore. In this episode you'll learn:The importance of being part of a strong angel community with peers you trust and whose opinion you valueHow Charlie thinks about activating his network as part of his diligence processWhy Charlie is going from a more international strategy to a more nationally focused oneWhy Charlie believes it's important to impose systematic professional processes on himself when angel investing
Today, we're happy to welcome you to David de Picciotto, Co-founder & CEO of Pledge, a climate software company helping decarbonise the logistics supply chain through its accredited and integrated platform. Founded in 2021 in the UK, Pledge is backed by venture investors including Zinal Growth, Lowercarbon Capital and Visionaries Club. Before Pledge, David worked for Partners Group, a global private equity firm, where he focused on growth equity investments and previously led International Expansion at Revolut, the UK FinTech. David is also the co-founder of media start-up iRewind, where he exited in 2016. David is also one of the trailblazing Sequoia scouts leading the charge in Europe
Today, we're happy to welcome David Nothacker, angel investor, CEO & co-founder of Sennder, a digital truck freight forwarding business. Together with his co-founders, David has built up a team of over 1,000 employees across eleven offices in Europe. In the process, they have been supported by strong investors such as Scania, Accel and Project A, and have secured over €300 million in funding. They are quite active angels, particularly in the German ecosystem.In this episode you will learn:Why David considers his investments into Gorillas and Cargo 1 his most memorable angel dealsDavid's learnings from managing startup boardsWhy David has two different, yet synergistic, investment strategies: investing early in logistics & supply chain startups and co-investing with VCs in opportunistic dealsHow LP investing can complement your angel activities when starting to do more international investmentsHow angel investing makes you a better, more experienced business leader
Today, we're happy to welcome you to Manolis Manassakis, CEO of Qogita, a leading global wholesale supplier revolutionizing the market through technology. He was formerly the Director of Operations for Europe, Middle East and Africa at Uber. Earlier in his career, he worked at Google as an Industry Manager, helping European businesses boost their online sales and make the most out of the web.Parallel to his work, Manolis co-founded Lawspot, providing openness and transparency to the law, to all citizens. Lawspot is now Greece's no1 open online hub for all things legal, trusted by 1M monthly users. Through Cloud Nine Ventures, Manolis is also an active angel investor, passionate about the European tech ecosystem, and loves helping startups and mentoring founders on operations, scaling and international expansion.
Today we're happy to welcome Anna Brandt and Noor van Boven, two amazing angel investors, co-founders of Invested. They accelerate growth through consulting and investing, being focused on the Future of Work, specifically when Fintech meets HR Tech.In this episode you'll learn:- How to think about joining forces as angels, what it takes and the superpowers it can give you- Why Anna & Noor pick their investments based on the problem the startups target, the disruption they can bring about and the connection, belief and match they have with the founding team- How Anna & Noor think about scaling their investment activity and what it takes from them as a team and individuals- Reflections on having invested through the boom and the bust cycle- How the team think about working with the European Venture ecosystem and to optimize their role in it
CardioNerds (Drs. Amit Goyal and Dan Ambinder) join Dr. Mina Fares, Dr. Johannes Bergehr, and Dr. Christina Peter from Cambridge University Hospitals in the UK. They discuss a case involving a man man in his 40's presented with progressive heart failure symptoms. He has extensive background cardiac history including prior episodes of myocarditis and complete heart block status post permanent pacemaker implantation. Ultimately a diagnosis of Danon disease is made. Dr. Sharon Wilson provides the E-CPR for this episode. Audio editing by CardioNerds Academy Intern, Hirsh Elhence. CardioNerds is collaborating with Radcliffe Cardiology and US Cardiology Review journal (USC) for a ‘call for cases', with the intention to co-publish high impact cardiovascular case reports, subject to double-blind peer review. Case Reports that are accepted in USC journal and published as the version of record (VOR), will also be indexed in Scopus and the Directory of Open Access Journals (DOAJ). CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Summary - A Presentation of Heart Failure and Heart Block with Elusive Genetic Origins - Cambridge University A man in his 40s with a history of cardiac issues, including prior myocarditis and complete heart block, presented with progressive heart failure symptoms. Extensive cardiac investigations were conducted, revealing dilated left ventricle, mild to moderate left ventricular systolic dysfunction, normal coronaries, infero-lateral late gadolinium enhancement on cardiac MRI, and low-level uptake on PET-CT. Differential diagnosis included worsening underlying cardiomyopathy, recurrent myocarditis, tachycardia-related cardiomyopathy, pacemaker-induced LV dysfunction, and sarcoidosis. The patient's condition improved with heart failure medications, and cardiac MRI showed a mildly dilated left ventricle with moderate systolic dysfunction and active inflammation in the anterior wall. Further evaluation indicated a family history of hereditary cardiomyopathy, and the patient exhibited phenotypic features such as early-onset heart disease, arrhythmias, family history of cardiomyopathy, learning problems, intellectual disability, and mild proximal myopathy. Genetic testing confirmed a LAMP2 mutation, leading to the diagnosis of Danon disease. Case Media - A Presentation of Heart Failure and Heart Block with Elusive Genetic Origins - Cambridge University Show Notes -A Presentation of Heart Failure and Heart Block with Elusive Genetic Origins - Cambridge University References - Danon, M. J., Oh, S. J., DiMauro, S., Miranda, A., De Vivo, D. C., & Rowland, L. P. (1981). Lysosomal glycogen storage disease with normal acid maltase. Neurology, 31(1), 51-7. Nishino, I., Fu, J., Tanji, K., Nonaka, I., & Ozawa, T. (2000). Mutations in the gene encoding LAMP2 cause Danon disease. Nature, 406(6798), 906-10. Tanaka, K., Nishino, I., Nonaka, I., Fu, J., & Ozawa, T. (2000). Danon disease is caused by mutations in the gene encoding LAMP2, a lysosomal membrane protein. Nature, 406(6798), 902-6. Maron, B. J., Haas, T. S., Ackerman, M. J., Ahluwalia, A., Spirito, P., Nishino, I., ... & Seidman, C. E. (2009). Hypertrophic cardiomyopathy and sudden death in a family with Danon disease. JAMA, 301(12), 1253-9. Hashem, S., Zhang, J., Zhang, Y., Wang, H., Zhang, H., Liu, L., ... & Wang, J. (2015). AAV-mediated gene transfer of LAMP2 improves cardiac function in Danon disease mice. Stem cells, 33(11), 2343-2350. Chi, L., Wang, H., Zhang, J., Zhang, Y., Liu, L., Wang, J., ... & Hashem, S. (2019). CRISPR/Cas9-mediated gene editing of LAMP2 in patient-derived iPSCs ameliorates Danon disease phenotypes.
The RSB Show 4-14-23 - Shai Danon, Life In Israel, Ula Tinsley, Fasting Tips, Lori Harvey
The past week has been a trying for Israelis, who reeled from a Palestinian gunman's attack outside an East Jerusalem synagogue. Seven people were killed as they finished their Friday Night Shabbat - or Sabbath - worship. Earlier this week, FOX News Rundown: Evening Edition host Eben Brown spoke with Knesset Member and former Israeli Ambassador to the UN Danny Danon about the attack and how Israel may respond. Danon is also a leader of the Israel Likud party, the conservative party of Benjamin Netanyahu, who only recently again became Prime Minister and whose new government feels the Palestinian attacks in recent weeks are a test of their leadership. We have plenty of fresh interviews each day during the week, and sometimes we have more to share. On today's FOX News Rundown, you will hear our interview with former Israeli Ambassador to the UN Danny Danon and get his take on the recent violence in Israel. Learn more about your ad choices. Visit megaphone.fm/adchoices
On Wednesday's Mark Levin Show, why isn't existing immigration law being enforced at the southern border? President Biden himself has admitted in the past that White Europeans will be a minority in the US due to a nonstop stream of immigration. Biden also ignores the antisemitism of the Buffalo, NY shooter and tries to blame the "replacement theory" that his administration perpetuates on Republicans. Rep. Rashida Tlaib's bigoted radicalism and hate for Jews has never been denounced by Democrats or the media. Then, Pelosi's select committee on January 6th is obtaining information that the Department of Justice could not normally obtain, so they are asking Congress to produce transcripts to use for their criminal investigation. This clever work-around violates the liberties of individuals and gives the DOJ an unfair advantage and a reach they wouldn't otherwise have. One's sworn testimony under oath for a legislative proceeding does not meet the same standard the government would have to compel testimony in front of a grand jury for a criminal proceeding. Moreover, subpoenaing President Trump's personal lawyer and former staff for delaying the certification of an election violates the separation of powers, because one has a right to legally challenge an election. Later, the results in the Pennsylvania US Senate primary are headed to a recount between the two highest vote-getters. In other election news Sen. Roy Blount's son draws scrutiny for work by his political canvassing company and lobbying against voter ID, while concealing the source of funding. Afterward, former Ambassador Danny Danon calls in to discuss his new book "In the Lion's Den: Israel and the World." Danon says Israel must remain strong because Israel has the same enemies America has just a lot closer to their homeland. Learn more about your ad choices. Visit megaphone.fm/adchoices
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