POPULARITY
2 episodes with ndd
2 episodes with ndd
3 episodes with ndd
2 episodes with ndd
2 episodes with ndd
3 episodes with ndd
3 episodes with ndd
3 episodes with ndd
2 episodes with ndd
Welcome to the Doulas Uncensored Podcast! Join hosts Sammy Griffin and Moran Liviani as they embark on this journey of exploration, education, and empowerment. In this episode, we speak with Emily Roper, a Neuro-Developmental Delay (NDD) therapist and midwife assistant from Colorado Springs. Emily is the owner and founder of Early Roots. She has a background in psychology, midwifery, and neuro-developmental delay, combined with a personal and family history of learning difficulties, making her uniquely qualified to help children with neuro-developmental delays. Emily first became interested in NDD therapy after witnessing its positive impact on her cousin. Emily graduated from the University of Central Oklahoma with a bachelor's degree in Psychology. During her studies, she spent a month in Colorado interning under an NDD therapist at Anna's House. During this internship, she learned about the significant impact that pregnancy and birth have on normal brain development. "In all of my developmental classes, my professors spent a lot of time on pregnancy and brain development. It was not until later that I realized labor and birth also have a huge impact on brain development,” she notes. In her senior year at UCO, Emily completed the necessary classes to become a childbirth doula. After college, she decided to further her education in midwifery. She was accepted into the Midwife's Assistant Program at the Oklahoma Midwives Alliance and began a clinical apprenticeship at Community Midwifery Services. Emily's expertise in neuro-development and midwifery provides her with a unique perspective on birth and its significance in childhood development. In this episode, Emily discusses integrated reflexes and their ongoing effects on childhood development, particularly when children miss out on these reflexes due to birth interventions or modes of delivery. She also shares how women can support themselves and their babies during pregnancy through movement. Emily's book recommendation are: Jordan Petersons ‘12 Rules for Life.' The Early Roots Podcast – with Emily Roper Early Roots Therapy - https://www.earlyrootstherapy.com/ The Imperfects – Food for Thought with Professor Felice Jacka - https://open.spotify.com/episode/1I8lOpJFuBUXDPwFTlEwpl So, sit back, relax, and let's uncover the untold stories, insights, and wisdom together on Doulas Uncensored. Sammy Griffin: sammygriffinbirthsupport.com Moran Liviani: 2life.com.au Disclaimer: Welcome to the Doulas Uncensored podcast! Before we dive into our episodes, we want to make sure we're all on the same page. First and foremost, while we strive to provide valuable information and resources, it's important to understand that the content shared on this podcast is not intended to serve as a substitute for medical or clinical advice. Our aim is to educate and inform, with the understanding that any application of this knowledge should be discussed with your healthcare provider. Additionally, please note that the content of our podcast may be supplemented, edited, or updated at any time. While we make every effort to maintain accuracy and completeness, we cannot guarantee the accuracy or currency of the information provided. Therefore, we accept no liability for any loss, damage, or unfavorable outcomes that may result from the use or reliance on the content presented here. Thank you for your understanding and for joining us on this journey of discovery and discussion!
Neste episódio do Pulso Empreendedor, Hernani Alves Melo, diretor de operações da PrintWay, compartilha sua inspiradora trajetória empresarial. A conversa aborda desde a fundação da PrintWay, uma empresa de software que monitora impressoras, até sua recente venda para a NDD. Hernani detalha a importância de uma boa governança, cultura organizacional, e consultorias especializadas na construção de um negócio saudável e preparado para oportunidades de mercado. Ele também reflete sobre o futuro pós-venda, destacando a importância de estar sempre preparado para novos desafios empreendedores.
“quick, quick, quick drop your things RIGHT NOW!!“you NEED to get over there”My friend was all zonked and blooming and bug-eyed. Her head dunked in a fluffy tempura of happy-hysteria.Her deep chocolate pudding eyes gave me the look “Hurry up, Fatso, get over there”“Why?” I want to go out for a snout and a coffee”Hastily, I dropped my things (which was actually nothing, as I didn't have anything in my bloody hands… how bloody hilarious… bloody HA. HA. ha)I ran and ran and ranthrough the lab-rat-white-piercing light,past armies of nameless names,doding Sycophantic Nause Bags plugging NDD up buyers jaxiesLunch! Trade ShowAhhhhh, yes. I remember. I remember with lucid clarity. That day I found FATSO.The name: FATSO.So bold. So cheeky. So going straight-in-my-f*cking-basket-boiiisheeeeThe flavours, spell-bindingly banging names and flavoursMorning Glory - “Cornflake and Marmalade”Nan's Stash - “Peanut, Toffee & Digestive Biscuit” (restraining order: por favor)King's Ransom - “Salted Pretzel, Whole Almond, Honeycomb”FATSO excites me widly.So excited to welcome the wonderful Ella on the poddy.She's totally amazing.You're in for a treat.ON THE MENU:How to build a brand a grow a baby at the same time - is it possible to manage pregnancy and brand building at the the same time?How to do more of what actually matters, why “More Matters” in life and brandHow to find slip stream channel where no one else is looking - the unobvious channel is where the obvious gold liesFatso 3 Field Sales Fundamentals: How to unlock any indie listing when you're feet on the streetWhy Challenger Food and Drink Founder must develop a “Slow Productivity” mindsetHow to Bring “Play” into work to avoid burnout - half the battle is just not burning out.Fully eppy Monday 8am.Others in the comments below xxx
A. MRD5 - https://www.ncbi.nlm.nih.gov/medgen/382611 B. SYNGAP1 NSID - https://pubmed.ncbi.nlm.nih.gov/21237447/ (Hamdan, 2011) C. SYNGAP1 NDD - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128754/ (Kilinc, 2011) D. Confusing https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.a.37189 (Parker, 2015) De Novo, Heterozygous, Loss-of-Function Mutations in SYNGAP1 Cause a Syndromic Form of Intellectual Disability E. SYNGAP1 DEE - https://pubmed.ncbi.nlm.nih.gov/30541864/ (Vlaskamp, 2019) F. SYNGAP1 Related-ID - ICD-10 & Hopkins - https://www.pnas.org/doi/abs/10.1073/pnas.2308891120 (Araki 2023) - https://curesyngap1.org/blog/syngap1-assigned-its-own-icd-10-code-f78-a1-srf/ (ICD-10, 2021) G. SYNGAP1 Related Disorders - https://www.chop.edu/conditions-diseases/syngap1-related-disorders H. SYNGAP1 Syndrome - ICD-11 - https://twitter.com/cureSYNGAP1/status/1730629792137883800 (2024) My vote (today) is that we have a disease that is a DEE called SYNGAP1 Related Disorders (SRD). These monogenic disorders are anything but monolithic. Disease vs. Syndrome, read this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1480257/ (Cavalo, 2003) A syndrome is a recognizable complex of symptoms and physical findings which indicate a specific condition for which a direct cause is not necessarily understood...Once medical science identifies a causative agent or process with a fairly high degree of certainty, physicians may then refer to the process as a disease, not a syndrome. NDD vs DEE - We are a DEE “Neurodevelopmental disorders (NDD) encompass highly prevalent conditions such as autism and epilepsy, with cognitive disabilities alone affecting 1-3% of the global population. Developmental epileptic encephalopathies (DEE) are NDD characterized by epilepsy and delayed development or loss of developmental skills. Although the prevalence of DEEs remains to be determined, studies estimate that single-gene epilepsies occur in around 1 in 2100 births annually.” https://medicalxpress.com/news/2022-12-neurodevelopmental-epilepsy-disorder-genetic.html Give all three of our podcasts 5 stars everywhere. https://podcasts.apple.com/us/channel/syngap1-podcasts-by-srf/id6464522917 This is a podcast subscribe! https://podcasts.apple.com/us/podcast/syngap10-weekly-10-minute-updates-on-syngap1/id1560389818 Episode 133 of #Syngap10 - Feb 13, 2024 #epilepsy #autism #intellectualdisability #id #anxiety #raredisease #epilepsyawareness #autismawareness #rarediseaseresearch #SynGAPResearchFund #CareAboutRare #PatientAdvocacy #GCchat #Neurology #GeneChat
In this brief episode we explore key questions such as: 1. What if we could use genetic evolution and modifying the ubiquitin-proteasome pathway for more targeted therapy in proteinopathies, for example utilizing directed evolution and protein engineering with ubiquitin or regions of the proteasome complex, to include antisense mRNA for key motifs apart of amyloid precursor protein (APP), PSEN1 or SNCA? Could we better target the histopathological hallmarks associated with Alzheimer's disease, such as the plaques of amyloid-beta, that are indicated in Alzheimer's disease progression?2. What if we could use different modified tRNA, or agents in the protein translation pathway, to facilitate therapy for NDD proteinopathies.In reference to question 1, check out this article on the UPS system in the body: The Ubiquitin–Proteasome System in Immune Cells .
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.550550v1?rss=1 Authors: Andrews, T. S., Nakib, D., Perciani, C., Ma, X. Z., Liu, L., Winter, E., Camat, D., Chung, S., Manuel, J., Mangroo, S., Hansen, B., Arpinder, B., Thoeni, C., Sayed, B., Feld, J., Gehring, A., Gulamhusein, A., Hirschfield, G. M., Rciutto, A., Bader, G. D., McGilvray, I. D., MacParland, S. A. Abstract: Background: Primary sclerosing cholangitis (PSC) is a serious immune-mediated cholestatic liver disease characterized by bile retention, biliary tree destruction, and progressive fibrosis leading to end stage liver disease and transplantation. There is an unmet need to understand the cellular composition of the PSC liver and how it underlies disease pathogenesis. As such, we generated a comprehensive atlas of the PSC liver and a reference healthy liver dataset using multiple multi-omic modalities with functional validation. Methods: In this work, we employed single-cell (12,000 cells), single-nuclei (23,000 nuclei) and spatial transcriptomics (1 sample by 10x Visium and 3 samples with multi-region profiling by Nanostring GeoMx DSP) to profile the cellular ecosystem in 5 patients with PSC. Transcriptomic profiles were compared to 100k single cell transcriptomes and spatial transcriptomics controls from 24 healthy neurologically deceased donor (NDD) livers. Flow cytometry and intracellular cytokine staining was performed to validate PSC-specific differences in immune phenotype and function. Results: PSC explants with cirrhosis of the liver parenchyma and prominent periductal fibrosis were associated with a unique population of hepatocytes which transformed to a cholangiocyte-like phenotype. Those hepatocytes were surrounded by diverse immune cell populations, including monocyte-like macrophages, liver-resident and circulating natural killer (NK) cells. Cytokines released by inflamed cholangiocytes and fibrosis-resident hepatic stellate cells and endothelial cells recruited CD4+T-cells, dendritic cells, and neutrophils to PSC liver tissues. Tissue-resident macrophages, by contrast, were reduced in number and exhibited a dysfunctional inflammatory response to LPS and IFN-{gamma} stimulation. Conclusions: We present the first comprehensive atlas of the PSC liver and demonstrate hyper-activation and exhaustion-like phenotypes of myeloid cells and markers of chronic cytokine expression in late-stage PSC lesions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550093v1?rss=1 Authors: Fenton, T., Haouchine, O., Hallam, E., Smith, E., Jackson, K., Rahbarian, D., Canales, C. P., Adhikari, A., Nord, A. S., Ben-Shalom, R., Silverman, J. L. Abstract: SYNGAP1 is a critical gene for neuronal development, synaptic structure, and function. Although rare, the disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability. Without functional SynGAP1 protein, patients present with intellectual disability, motor impairments, and epilepsy. Previous work using mouse models with a variety of germline and conditional mutations has helped delineate SynGAP1's critical roles in neuronal structure and function, as well as key biochemical signaling pathways essential to synapse integrity. Homozygous loss of SYNGAP1 is embryonically lethal. Heterozygous mutations of SynGAP1 result in a broad range of phenotypes including increased locomotor activity, impaired working spatial memory, impaired cued fear memory, and increased stereotypic behavior. Our in vivo functional data, using the original germline mutation mouse line from the Huganir laboratory, corroborated robust hyperactivity and learning and memory deficits. Here, we describe impairments in the translational biomarker domain of sleep, characterized using neurophysiological data collected with wireless telemetric electroencephalography (EEG). We discovered Syngap1+/- mice exhibited elevated spike trains in both number and duration, in addition to elevated power, most notably in the delta power band. Primary neurons from Syngap1+/- mice displayed increased network firing activity, greater spikes per burst, and shorter inter-burst intervals between peaks using high density micro-electrode arrays (HD-MEA). This work is translational, innovative, and highly significant as it outlines functional impairments in Syngap1 mutant mice. Simultaneously, the work utilized untethered, wireless neurophysiology that can discover potential biomarkers of Syngap1R-ID, for clinical trials, as it has done with other NDDs. Our work is substantial forward progress toward translational work for SynGAP1R-ID as it bridges in-vitro electrophysiological neuronal activity and function with in vivo neurophysiological brain activity and function. These data elucidate multiple quantitative, translational biomarkers in vivo and in vitro for the development of treatments for SYNGAP1-related intellectual disability. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.08.548192v1?rss=1 Authors: Aguilan, J., Pedrosa, E., Dolstra, H., Nur Baykara, R., Barnes, J., Zhang, J., Sidoli, S., Lachman, H. Abstract: Background: Jansen de Vries Syndrome (JdVS) is a rare neurodevelopmental disorder (NDD) caused by gain-of-function (GOF) truncating mutations in PPM1D exons 5 or 6. PPM1D is a serine/threonine phosphatase that plays an important role in the DNA damage response (DDR) by negatively regulating TP53 (P53). JdVS-associated mutations lead to the formation of a truncated PPM1D protein that retains catalytic activity and has a GOF effect because of reduced degradation. Somatic PPM1D exons 5 and 6 truncating mutations are well-established factors in a number of cancers, due to excessive dephosphorylation and reduced function of P53 and other substrates involved in DDR. Children with JdVS have a variety of neurodevelopmental, psychiatric, and physical problems. In addition, a small fraction has acute neuropsychiatric decompensation apparently triggered by infection or severe non-infectious environmental stress factors. Methods: To understand the molecular basis of JdVS, we developed an induced pluripotent stem cell (iPSC) model system. iPSCs heterozygous for the truncating variant (PPM1D+/tr), were made from a patient, and control lines engineered using CRISPR-Cas9 gene editing. Proteomics and phosphoprotemics analyses were carried out on iPSC-derived glutamatergic neurons and microglia from three control and three PPM1D+/tr iPSC lines. We also analyzed the effect of the TLR4 agonist, lipopolysaccharide, to understand how activation of the innate immune system in microglia could account for acute behavioral decompensation. Results: One of the major findings was the downregulation of POGZ in unstimulated microglia. Since loss-of-function variants in the POGZ gene are well-known causes of autism spectrum disorder, the decrease in PPM1D+/tr microglia suggests this plays a role in the neurodevelopmental aspects of JdVS. In addition, neurons, baseline, and LPS-stimulated microglia show marked alterations in the expression of several E3 ubiquitin ligases, most notably UBR4, and regulators of innate immunity, chromatin structure, ErbB signaling, and splicing. In addition, pathway analysis points to overlap with neurodegenerative disorders. Limitations: Owing to the cost and labor-intensive nature of iPSC research, the sample size was small. Conclusions: Our findings provide insight into the molecular basis of JdVS and can be extrapolated to understand neuropsychiatric decompensation that occurs in subgroups of patients with ASD and other NDDs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.27.538584v1?rss=1 Authors: Echevarria-Cooper, D. M., Kearney, J. A. Abstract: Pathogenic variants in SCN2A are associated with a range of neurodevelopmental disorders (NDD). SCN2A-related NDD show wide phenotypic heterogeneity, suggesting that modifying factors must be considered in order to properly elucidate the mechanisms of pathogenic variants. Recently, we characterized neurological phenotypes in a mouse model of the variant SCN2A-p.K1422E. We demonstrated that heterozygous Scn2aK1422E female mice showed a distinct, reproducible distribution of flurothyl-induced seizure thresholds. Women with epilepsy often show a cyclical pattern of altered seizure susceptibility during specific phases of the menstrual cycle which can be attributed to fluctuations in hormones and corresponding changes in neurosteroid levels. Rodent models have been used extensively to examine the relationship between the estrous (menstrual) cycle, steroid hormones, and seizure susceptibility. However, the effects of the estrous cycle on seizure susceptibility have not been evaluated in the context of an epilepsy-associated genetic variant. To determine whether the estrous cycle affects susceptibility to flurothyl-induced seizures in Scn2aK1422E female mice, estrous cycle monitoring was performed in mice that had undergone ovariectomy (OVX), sham surgery, or no treatment prior to seizure induction. Removing the influence of circulating sex hormones via OVX did not affect the non-unimodal distribution of flurothyl seizure thresholds observed in Scn2aK1422E females. Additionally, flurothyl seizure thresholds were not associated with estrous cycle stage in mice that underwent sham surgery or were untreated. These data suggest that variation in Scn2aK1422E flurothyl seizure threshold is not significantly influenced by the estrous cycle and, by extension, fluctuations in ovarian hormones. Interestingly, untreated Scn2aK1422E females showed evidence of disrupted estrous cyclicity, an effect not previously described in a genetic epilepsy model. This unexpected result highlights the importance of considering sex specific effects and the estrous cycle in support of more inclusive biomedical research. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527866v1?rss=1 Authors: Kim, J., Vanrobaeys, Y., Peterson, Z., Kelvington, B., Gaine, M. E., Nickl-Jockschat, T., Abel, T. Abstract: Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants (CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of striatal circuits is considered a central mechanism in NDDs. The 16p11.2 hemi-deletion (16p11.2 del) is one of the most common CNVs associated with NDD, and 16p11.2 del/+ mice show sex-specific striatum-related behavioral phenotypes. However, the critical genes among the 27 genes in the 16p11.2 region that underlie these phenotypes remain unknown. Previously, we applied a novel strategy to identify candidate genes associated with the sex-specific phenotypes of 16p11.2 del/+ mice and identified 3 genes of particular importance within the deleted region: thousand and one amino acid protein kinase 2 (Taok2), seizure-related 6 homolog-like 2 (Sez6l2), and major vault protein (Mvp). Using the CRISPR/Cas9 technique, we generated 3 gene hemi-deletion (3g del/+) mice carrying null mutations inTaok2, Sez6l2, and Mvp. We assessed striatum-dependent phenotypes of these 3g del/+ mice in behavioral, molecular, and imaging studies. Hemi-deletion of Taok2, Sez6l2, and Mvp induces sex-specific behavioral alterations in striatum-dependent behavioral tasks, specifically male-specific hyperactivity and impaired motivation for reward seeking, resembling behavioral phenotypes of 16p11.2 del/+ mice. Moreover, RNAseq analysis revealed that 3g del/+ mice exhibit gene expression changes in the striatum similar to 16p11.2 del/+ mice, but only in males. Pathway analysis identified ribosomal dysfunction and translation dysregulation as molecular mechanisms underlying male-specific, striatum-dependent behavioral alterations. Together, the mutation of 3 genes within the 16p11.2 region phenocopies striatal sex-specific phenotypes of 16p11.2 del/+ mice, unlike single gene mutation studies. These results support the importance of a polygenic approach to study NDDs and our novel strategy to identify genes of interest using gene expression patterns in brain regions, such as the striatum, which are impacted in these disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.15.520643v1?rss=1 Authors: Kozhemiako, N., Buckley, A. W., Chervin, R. D., Redline, S., Purcell, S. M. Abstract: Profiles of sleep duration and timing and corresponding electroencephalographic activity reflect brain changes that support cognitive and behavioral maturation and may provide practical markers for tracking typical and atypical neurodevelopment. To build and evaluate a sleep-based, quantitative metric of brain maturation, we used whole-night polysomnography data, initially from two large National Sleep Research Resource samples, spanning childhood and adolescence (total N = 4,013, aged 2.5 to 17.5 years): the Childhood Adenotonsillectomy Trial (CHAT), a research study of children with snoring without neurodevelopmental delay, and NCH, a pediatric sleep clinic cohort. Among children without developmental disorders, sleep metrics derived from the electroencephalogram (EEG) displayed robust age-related changes consistently across datasets. Prominent stage-, band- and channel-specific developmental trajectories in spectral power were found. During non-rapid eye movement (NR) sleep, spindles and slow oscillations further exhibited characteristic developmental patterns, with respect to their rate of occurrence, temporal coupling and morphology. Based on these metrics in NCH, we constructed a model to predict an individual's chronological age. The model performed with high accuracy (r = 0.95 in the held-out NCH testing sample and r = 0.88 in a second independent replication sample (PATS) with a broadly comparable age range). EEG-based age predictions reflected clinically meaningful neurodevelopmental differences; for example, compared to typically developing children, those with neurodevelopmental diagnoses (NDD) showed greater variability in predicted age, and children with Down syndrome or intellectual disability had significantly younger brain age predictions (respectively, 2.2 and 0.59 years less than their chronological age) compared to age-matched non-NDD children. Overall, our results indicate that sleep architecture offers a sensitive window for characterizing brain maturation, suggesting the potential for scalable, objective sleep-based biomarkers to measure typical and atypical neurodevelopment. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.06.506845v1?rss=1 Authors: Meng, X., Yao, D., Kelley, K. W., Reis, N., Thete, M. V., Kulkarni, S., Bassik, M. C., Pasca, S. P. Abstract: The assembly of cortical circuits involves the generation and migration of cortical interneurons from the ventral to the dorsal forebrain, which has been challenging to study in humans as these processes take place at inaccessible stages of late gestation and early postnatal development. Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs) have been associated with abnormal cortical interneuron development, but which of the hundreds of NDD genes impact interneuron generation and migration into circuits and how they mediate these effects remain unknown. We previously developed a stem cell-based platform to study human cortical interneurons in self-organizing organoids resembling the ventral forebrain and their migration using forebrain assembloids. Here, we integrate assembloid technology with CRISPR screening to systematically investigate the involvement of 425 NDD genes in human interneuron development. The first screen aimed at interneuron generation revealed 13 candidate genes, including the RNA-binding protein CSDE1 and the canonical TGF{beta} signaling activator SMAD4. Then, we ran an interneuron migration screen in ~1,000 forebrain assembloids that identified 33 candidate genes, including cytoskeleton-related genes and, notably, the endoplasmic reticulum (ER)-related gene LNPK. Interestingly, we discovered that, during interneuron migration, the ER is displaced along the leading neuronal branch prior to nuclear translocation. Deletion of LNPK interfered with this ER displacement and resulted in reduced interneuron saltation length, indicating a critical role for the ER in this migratory process. Taken together, these results highlight how this versatile CRISPR-assembloid platform can be used to systematically map disease genes onto early stages of human neural development and to reveal novel mechanisms regulating interneuron development. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
The first seven minutes sound a bit rough as we had some microphone issues, but stick with it as there are 3 HOURS of goodness with your favourite borderline humans / Scott is on the MD 20/20 mixed with Buckfast tonight / Lurch is handing out the best gifts / Steev isn't dead! But he did suffer a pretty bad medical issue / Maynard still looks like a chiseled Adonis / Somebody pooped on a dog / What is 'The Justice Van'? / Stand back NDD, we now have NDR / Some horrible brute peed in Lurch's sink / Scott gets accused of being a bit heavy-handed with the tiny gingers / All this and a shed-load more on tonights DHB Radio Show!
INTRO: This week on The Less Stressed Life Podcast, I am joined by Abigail Hueber. In this conversation, we dive into the mind-body connection and how the energetics of emotional health can impact your physical health.KEY TAKEAWAYS:The energetics of emotional health impact physical healthThere are certain organs that tend to hold different types of emotionsWe have much more control over our health via our own consciousness than just what the supplements or physical tools can do.GUEST SHARED HELPFUL TIPS ON:What to do when you are doing the work but not getting better How to support your mind-body connection as part of the healing process emotions sit in your bodyHow to reconnect with your body when you are feeling stuck in your headABOUT GUEST:Abigail Hueber is an Integrative Functional Dietitian and owner of the private practice Above Health Nutrition. Abigail is an expert in digestive health and the creator of the No Drama Digestion Program (NDD), an online program that helps clients to eliminate symptoms of IBS and other digestive issues. Through functional medicine tools, the NDD program works to identify and eliminate the root cause of IBS in the body through nutrition, lifestyle and personalized supplementation to provide long-term digestive healing and optimize overall health. WHERE TO FIND :Website: https://www.abovehealthnutrition.com/ IG: @abovehealthWHERE TO FIND CHRISTA:https://www.christabiegler.com/On IG:instagram.com/anti.inflammatory.nutritionist/Shop our Favoriteschristabiegler.com/shopLoving the podcast? Leave us a review and ENTER OUR GIVEAWAY NOW!Sharing & reviewing this podcast is the BEST way to help us succeed with our mission to help integrate the best of East & West empower you to raise the bar on your health story. Just go to https://reviewthispodcast.com/lessstressedlifeSPONSORS:A special thanks to our VIP sponsor RUPA Health, our lab concierge service that helps our clients get standard bloodwork 2/3 off retail direct to consumer lab test pricing. Let them know I sent you when you sign up for your free practitioner account.
Sometimes all you need is to spend time in the great outdoors, where you soak up the sunshine, breathe fresh air, and commune with wildlife. Getting out for a walk in your local park or even birding alone or with your family can have a powerful impact on your brain. Birding by itself teaches us patience and gently coaxes us to be calm. It's a great opportunity to just zone out or have a little reflection and think calmly. Our guest for today will definitely agree on that matter. According to Ryan Dibala of Birding Man Adventures, birding is a great way for people to get outdoors and connect with nature. --- Listen to the podcast here: Birding with Benefits: How Nature Improves Your Well Being with Ryan Dibala Welcome to Action's Antidotes, your antidote to the mindset that keeps you settling for less. Today, I'd like to switch gears with you a little bit and I'd like to talk to you about birding. Now, this is a topic that we have yet to discuss on this particular podcast because it's a type of experience that people either know a lot about or know very little about. Some people get really, really into birding and some people just don't know much about it. But, in life, there's going to be a lot of experiences like that and it's good to be exposed to the large depth of experiences that there are out there. According to my guest today, Ryan Dibala of Birding Man Adventures, birding is a great way for people to get outdoors and connect into nature. --- Ryan, welcome to the program. Pleasure to be here, Steve. Thanks for having me. Oh, thank you so much. And, Ryan, tell me about your experience with birding. What made birding be the thing that you wanted to, first of all, do a lot of yourself and also bring to others? Right after college, I was working as a biologist on Santa Catalina Island and we were actually restoring bald eagles to the national park after a massive decline in numbers due to DDT, which I'm sure many people are familiar with DDT and what it did as it worked its way up the food chain, essentially with the raptors, like bald eagles, it depleted their egg shells of calcium so the nesting eagles would crush the eggs and then that would prevent successful recruitment ultimately. So we were actually involved in the direct manipulations of eggs and chicks on the island's eagles' nests so, of course, I was around other birders, I had my first pair of binoculars and a spotting scope and I was able to tune into some of the smaller birds on the island. That particular island has several different endemics that only are there, like many islands have, they have species that only can be found on those islands so I think I saw, it was a Hutton's Vireo, a Catalina Hutton's Vireo, and that might have been my gateway bird, I guess you could call it. A gateway bird, never heard it described that way before. So ever since that moment, I've really been paying attention to the birds around me. I found that it really slows me down, it helps me focus. We have these weapons of mass distraction in our pockets and we're always on them, these cell phones that distract us from the world and prevent us from tuning into what's in front of our eyes at the present moment. And so, as a result, we've seen a lot more ADD and NDD, nature deficit disorder, and realizing that going out into nature and slowing down and looking at the world as it is right around me, that's helped center me and relieve a lot of anxiety that has come about from the world that we live in with so much technology so that's one of many reasons that I continue to bird today. I can certainly go into more of the reasons why I think it's an amazing pursuit and something that more people should do. What does birding entail? Like if, let's say, these podcasts usually come out on Tuesdays and if you're listening in the middle of the week and someone says, “Alright, this sounds really interesting.
Join Sasquatch and Lurch as they talk about how the recording space is a disgusting masturbatory splash-zone / The Roobs is at the martial arts, Scott was sad it wasn't 'marital' / Lurch was accosted over a fence / Scott still stressing about the new format / Thanks to everyone that's supported the show over at ko-fi.com/doghousescott / Lurch opens up about more of the NDD drama / Lurch has seen more puss-puss this week than the council stray catcher / All this and more on this weeks DHB Radio Show!
The Bottom Line by Evolved Finance explores the financial journeys of some of the most successful online educators, thought leaders, influencers, and service providers in the online space. Each week, Parker sits down with a current Evolved Finance client to talk about their relationship with money and how their mindset has changed as their business has grown. This week, Parker chats with Abigail Hueber. Abigail is an Integrative Functional Dietitian and owner of the private practice Above Health Nutrition. She is an expert in digestive health and the creator of the No Drama Digestion Program (NDD), an online program that helps clients to eliminate symptoms of IBS and other digestive issues. Through the tools of functional medicine, the NDD program works to identify and eliminate the root cause of IBS in the body through nutrition, lifestyle, and personalized supplementation to provide long-term digestive healing and optimize overall health. To learn more about Evolved Finance: Follow us on iTunes and leave a review: https://podcasts.apple.com/us/podcast/evolved-finance/id1227529139 Download our free audio course: www.evolvedfinance.com/audiocourse Join our private Facebook Group: https://www.facebook.com/groups/evolvedfinance To learn more about Abigail Hueber and her business: NDD Program: https://above-health-nutrition.mykajabi.com/NoDramaDigestion Complementary strategy call for interested clients: https://www.abovehealthnutrition.com/workwithme Instagram: https://www.instagram.com/abovehealth/
Early intervention is critical to treating neurodevelopmental disorders, like cerebral palsy. But just how early can we diagnose them?In this episode, Jessica is joined by Professors Jane Valentine and Catherine Elliott, whose international Early Moves project is able to diagnose children with cerebral palsy as early as three months of age. Together, they discuss examples of neurodevelopmental disorders, the progress made in early diagnosis and treatment, and the role that Early Moves is playing, as the largest trial in the world identifying early biomarkers for neurodevelopmental disorders.Early Moves is a research study led by Curtin University and Perth Children's Hospital in partnership with the ORIGINS project, in Western Australia. It receives funding from the National Health and Medical Research Council, Telethon 7 Trust, The Cerebral Palsy Alliance, Western Australia Child Research Fund, Mineral Resources Limited and Perth Children's Hospital Foundation.Examining neurodevelopmental disorders [01:12]Tapping into a child's peak period of neuroplasticity [04:32]What is the Early Moves project? [06:40]Role of parents and how they're supported [09:55] Next steps for the research [13:09]How did Professors Valentine and Elliott come to work on the project? [14:45]Learn morePerth Children's Hospital Fondation: The Early Moves ProjectTelethon Kids Institute: The Origins Project: Early MovesHeckman: Invest in Early Childhood DevelopmentHammersmith Neurological ExaminationsCerebral Palsy Alliance: What is the General Moves Assessment?Connect with our guestsProfessor Jane Valentine is a Senior Consultant Paediatrician at Perth Children's Hospital, Head of Research at Kids Rehab WA and an Honorary Research Fellow at the Telethon Kids Institute.She is part of the international team that published the international guidelines for the early detection of cerebral palsy and the International Clinical Practice Guideline Based on Systematic Reviews, for early intervention for children with or at risk of cerebal palsy. Professor Valentine's Telethon Kids Institute staff profileProfessor Valentine's Curtin staff profile Professor Catherine Elliott is the Director of Research at the Telethon Kids Institute and a researcher in Curtin University's School of Allied Health. Her research focuses on improving the outcomes for babies and children who have neurological impairment. The National Health and Medical Research Council is supporting her research to explore early indicators of cognitive impairment in babies younger than three months old.Professor Elliott's LinkedIn profileProfessor Elliott's Curtin staff profileJoin Curtin UniversityThis podcast is brought to you by Curtin University. Curtin is a global university known for its commitment to making positive change happen through high-impact research, strong industry partnerships and practical teaching.Work with usStudy a research degreeStart postgraduate educationGot any questions, or suggestions for future topics?Email thefutureof@curtin.edu.auSocialshttps://twitter.com/curtinunihttps://www.facebook.com/curtinuniversityhttps://www.instagram.com/curtinuniversity/https://www.youtube.com/user/CurtinUniversityhttps://www.linkedin.com/school/curtinuniversity/ Transcripthttps://thefutureof.simplecast.com/episodes/neurodevelopmental-disorders-in-children/transcript Behind the scenesThis episode came to fruition thanks to the combined efforts of:Jessica Morrison, HostJarrad Long, Executive ProducerAnnabelle Fouchard, ProducerKaren Green, Episode Researcher Daniel Jauk, Episode EditorAlexandra Eftos, Recordist and Assistant ProducerAmy Hosking, Social Media. Curtin University supports academic freedom of speech. The views expressed in The Future Of podcast may not reflect those of Curtin University.Music: OKAY by 13ounce Creative Commons — Attribution-ShareAlike 3.0 Unported — CC BY-SA 3.0 Music promoted by Audio Library.
Today we talked about how her kids have NDD and that she wants Eductors & Medical professionals to help better via Human Center Design. Julie's Contact info is jlyang@umn.edu and she can be reached there. My info is 763-340-4155 and info is Uniquelyusguild@gmail.com
You might be thinking, "well, I don't see that many NDD kids". The reality is if you see kids at all in your practice, with the amount of typically developing kids who are struggling after these last two years, you are seeing kids who need you to know a little more! Trust me, they're in your practice already and in your community! As Chiropractors, this is what we do! We help people adapt to stress. If you want to make a bigger impact and leave the musculoskeletal (only) realm, you
Katrina Strohl is a Navy veteran, an aviation structural mechanic who has literally turned her life around. She is now a certified career coach and host of the “Absolutely Not” podcast which is dedicated to creating a healthy workplace. She sits down with JD and Suzy to tell her story including her own struggle with mental health. What You Will Hear: Resilience being the theme of Katrina's life right now Intersectionality and identities PTSD, NDD and alcoholism diagnosis during Katrina's military service Katrina's journey from military service to entrepreneurship Katrina's multiple attempts to take her own life and how that drove her to become a counselor. Boundaries, self awareness and the importance of both. Psychological first aid Foster care system the good and the bad. Quotes “My opinions and ideals come in a rainbow effect.” “I didn't know how to name the harm that was being placed upon me.” Mentioned: http://www.katrinastrohl.com/ (www.katrinastrohl.com)
LISTEN.. I am seeing so many chiropractors miss some fundamental things when working with the NDD world! I am on a mission to debunk some myths... Let's start with the story I hear so many of you saying.... "the parents are hard to work with". Copyright © 2021 FOCUS Educational Services, LLC. All rights reserved Dr. Amy and her husband David live in Coeur d'Alene, ID with their beautiful daughter Meela and chocolate lab Izzy. They opened Spoelstra Family Chiropractic in April of 2008 after moving from South Carolina where Dr. Amy graduated cum laude from Sherman College of Chiropractic. Dr. Amy is the founder of the FOCUS program and opened the doors to the program in 2011 in the Coeur d' Alene office. She now teaches chiropractors, educators, and other medical professionals around the country and internationally about Neuro-Deflective Disorders™ and the FOCUS approach to comprehensive patient care for children and adults with behavioral, learning, socialization, and developmental challenges. She is the founder of the Brain Blossom Program™ and FOCUS Academy ™ for continued education for certified FOCUS practitioners. Find out more about Dr. Amy's FOCUS program here: https://gofocusacademy.com Register for the FOCUS Seminar: https://gofocusacademy.com Facebook: https://www.facebook.com/thefocusacademyDrAmy Facebook Chiropractic Free VIP Group: https://www.facebook.com/groups/focusacademyvipchiro IG: @theFOCUSacademyDrAmy Podcasts: https://soundcloud.com/dramyfocus/are-you-keeping-your-side-of-the-road-clean https://podcasts.apple.com/us/podcast/dr-amy-focus/id1523547907 https://www.stitcher.com/podcast/dr-amy-focus
Dr. Sonia McGowin is a leader in the pediatric NDD world and incorporating FOCUS into her practice! She shares how her personal and professional experience has helped her to help others! Copyright © 2021 FOCUS Educational Services, LLC. All rights reserved Dr. Amy and her husband David live in Coeur d'Alene, ID with their beautiful daughter Meela and chocolate lab Izzy. They opened Spoelstra Family Chiropractic in April of 2008 after moving from South Carolina where Dr. Amy graduated cum laude from Sherman College of Chiropractic. Dr. Amy is the founder of the FOCUS program and opened the doors to the program in 2011 in the Coeur d' Alene office. She now teaches chiropractors, educators, and other medical professionals around the country and internationally about Neuro-Deflective Disorders™ and the FOCUS approach to comprehensive patient care for children and adults with behavioral, learning, socialization, and developmental challenges. She is the founder of the Brain Blossom Program™ and FOCUS Academy ™ for continued education for certified FOCUS practitioners. Find out more about Dr. Amy's FOCUS program here: https://gofocusacademy.com Register for the FOCUS Seminar: https://gofocusacademy.com Facebook: https://www.facebook.com/thefocusacademyDrAmy Facebook Chiropractic Free VIP Group: https://www.facebook.com/groups/focusacademyvipchiro IG: @theFOCUSacademyDrAmy Podcasts: https://soundcloud.com/dramyfocus/are-you-keeping-your-side-of-the-road-clean https://podcasts.apple.com/us/podcast/dr-amy-focus/id1523547907 https://www.stitcher.com/podcast/dr-amy-focus
Who shall live?Meet senior transplant coordinator Doug Penrod. Each of our podcasts feature either a living donor, or a transplant expert. Doug is both an expert and a living donor which makes him the first Donor Diaries Double Dipper! Join Doug and Laurie as they discuss the controversial aspects of dialysis in America and what is being done to ensure that dialysis patients understand their option to get a kidney transplant. Find out what a “God Committee” is and learn how they determined who would live or die in the early years of dialysis machines. Find out what compelled Doug to become a living kidney donor himself after over 20 years of working with organ donors and recipients.Episode LinksDonor DiariesOrgan Donor Registry (deceased donation)National Kidney Donor Organization (NKDO) (living donation)Who Shall Live? (God Committees)Dialysis: Last Week Tonight with John Oliver
Donor Diaries is a podcast about the beauty and messiness of living organ donation. Get ready for some amazing stories about what happens when people decide to share their organs with other people, when people chose to share life. The sharing of kidneys and other organs is an incredibly fascinating topic that teaches a lot about kindness, love, and life!There are over 100,000 people on the kidney transplant waitlist today, and sadly about 13 people die each day waiting for a kidney that they never receive. One in three Americans are at risk for developing chronic kidney disease and one in nine already have kidney disease. Most don't even know it. Donor Diaries shares unfiltered stories of kidney donation through the voices of living donors and straight talk from transplant experts who are committed to bringing the conversation of living organ donation to the forefront of society, so patients no longer have to die or suffer while waiting for a transplant.Episode LinksDonor DiariesOrgan Donor Registry (deceased donation)National Kidney Donor Organization (NKDO) (living donation)
How do you ask somebody for a kidney? Meet Johnna, a Chicago area woman with Polycystic Kidney Disease (PKD). Johnna is in stage 5 kidney failure and needs a kidney transplant. She can wait 5-7 years for a deceased donor kidney to become available, or she can find a friend or family member to become a living kidney donor on her behalf, and get a new kidney right now. Find out what happens when Johnna's longtime friend Mary decides to step forward to be tested as a match!Episode LinksJohnna Needs a KidneyPKD FoundationDonor DiariesOrgan Donor Registry (deceased donation)National Kidney Donor Organization (NKDO) (living donation)
O Fora da Caixa dessa edição foi com Anderson Locatelli CEO da Sled, ele que possui mais de 13 anos de experiência em negociações e consolidação de alianças estratégicas entre empresas renomadas de tecnologia e meios de pagamento. Fundou a Sled e foi Diretor de Alianças e de Mercado da NDD liderando times em 05 países.
NDD is out, IDDSI is IN! Find out more with Michele Kramer and Theresa Argwello-Thomas today on Health Care High Wire!
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
The conversation continues in this next podcast about how the COVID pandemic is impacting children with NDD and exceptional learning needs. Dr. Ripudaman Minhas, Developmental Paediatrician shares his observations from his work with the Inner City Health Program at St. Michael's Hospital and emphasizes just how essential the school environment is for children's development.
Join me as I chat with Dr. Olaf Kraus de Camargo & Dr. Kinga Pozniak about the findings from their cross-Canada, mixed methods survey, of the Caregiver experience during the early months of the COVID pandemic. Families & caregivers identified many gaps in essential services including access to therapies, respite support and online education - issues that continue to impact individuals with NDD several months later.
Join me as I talk with a mother of two sons with NDD about their experience during the first few months of the COVID pandemic. She speaks about the distress of having one son contract the virus, online schooling and the need for more supports to help families.
Programa 360° de Noches de Disco, transmitido por la frecuencia de NRG Radio FM el 20 de octubre de 2020 con su anfitrión Janztech celebrando el Séptimo Aniversario de NDD en 8D Audio | www.nrgradiofm.mx | www.hinrgmexico.org | http://noches-de-disco.blogspot.mx/
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.12.336586v1?rss=1 Authors: Rahn, R. M., Weichselbaum, C. T., Gutmann, D. H., Dougherty, J. D., Maloney, S. E. Abstract: Motor deficits such as abnormal gait are an underappreciated yet characteristic phenotype of many neurodevelopmental disorders (NDDs), including Williams Syndrome (WS) and Neurofibromatosis Type 1 (NF1). Compared to cognitive phenotypes, gait phenotypes are readily and comparably assessed in both humans and model organisms, and are controlled by well-defined CNS circuits. Discovery of a common gait phenotype between NDDs might suggest shared cellular and molecular deficits and highlight simple outcome variables to potentially quantify longitudinal treatment efficacy in NDDs. We therefore characterized gait using the DigiGait assay in two different murine NDD models: the complete deletion (CD) mouse, which models hemizygous loss of the complete WS locus, and the Nf1+/R681X mouse, which models a NF1 patient-derived heterozygous germline NF1 mutation. Longitudinal data were collected across five developmental time points (postnatal days 21-30) and one early adulthood time point. Compared to wild type littermate controls, both models displayed markedly similar spatial, temporal, and postural gait abnormalities during development. Developing CD mice also displayed significant decreases in variability metrics. Multiple gait abnormalities observed across development in the Nf1+/R681X mice persisted into early adulthood, including increased stride length and decreased stride frequency, while developmental abnormalities in the CD model largely resolved by adulthood. These findings suggest that the subcomponents of gait affected in NDDs show overlap between disorders as well as some disorder-specific features, which may change over the course of development. Our incorporation of spatial, temporal, and postural gait measures also provides a template for gait characterization in other NDD models, and a platform to examining circuits or longitudinal therapeutics. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.247080v1?rss=1 Authors: Gong, N. N., Chakravarti Dilley, L., Williams, C. E., Moscato, E. H., Szuperak, M., Wang, Q., Jensen, M., Girirajan, S., Tan, T. Y., Deardorff, M. A., Li, D., Song, Y., Kayser, M. S. Abstract: Sleep disruptions are among the most commonly-reported symptoms across neurodevelopmental disorders (NDDs), but mechanisms linking brain development to normal sleep are largely unknown. From a Drosophila screen of human NDD-associated risk genes, we identified the chromatin remodeler Imitation SWItch/SNF (ISWI) to be required for adult fly sleep. Loss of ISWI also results in disrupted circadian rhythms, memory, and social behavior, but ISWI acts in different cells and during distinct developmental times to affect each of these adult behaviors. Specifically, ISWI expression in type I neuroblasts is required for both adult sleep and formation of a learning-associated brain region. Expression in flies of the human ISWI homologs SMARCA1 and SMARCA5 differentially rescue adult phenotypes. We propose that sleep deficits are a primary phenotype of early developmental origin in NDDs, and point towards chromatin remodeling machinery as critical for sleep circuit formation. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.17.209551v1?rss=1 Authors: Fernandes, D. J., Spring, S., Roy, A. R., Qiu, L. R., Yee, Y., Neiman, B. J., Lerch, J. P., Palmert, M. R. Abstract: Maternal environmental exposures, such as high-fat diets, diabetes and obesity, can induce long term effects in offspring. These effects include increased risk of neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), depression and anxiety. The mechanisms underlying these late-life neurologic effects are unknown. In this article, we measured changes in the offspring brain and determined which brain regions are sensitive to maternal metabolic milieu and therefore may mediate NDD risk. We showed that mice exposed to maternal high-fat diet display extensive brain changes in adulthood despite being switched to low-fat diet at weaning. Brain regions impacted by early-life diet include the extended amygdalar system, which plays an important role in reward-seeking behaviour. Genes preferentially expressed in these regions have functions related to feeding behavior, while also being implicated in human NDDs, such as autism. Our data demonstrated that exposure to maternal high-fat diet in early-life leads to brain alterations that persist into adulthood, even after dietary modifications. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.27.175489v1?rss=1 Authors: Chau, K., Zhang, P., Urresti, J., Amar, M., Pramod, A. B., Thomas, A., Corominas, R., Lin, G. N., Iakoucheva, L. M. Abstract: Alternative splicing plays important role in brain development, however its global contribution to human neurodevelopmental diseases (NDD) has not been fully investigated. Here, we examined the relationships between splicing isoforms expression in the brain and de novo loss-of-function mutations identified in the patients with NDDs. We constructed isoform transcriptome of the developing human brain, and observed differentially expressed isoforms and isoform co-expression modules undetectable by the gene-level analyses. These isoforms were enriched in loss-of-function mutations and microexons, co-expressed with a unique set of partners, and had higher prenatal expression. We experimentally tested the impact of splice site mutations in five NDD risk genes, including SCN2A, DYRK1A and BTRC, and demonstrated exon skipping. Furthermore, our results suggest that the splice site mutation in BTRC reduces translational efficiency, likely impacting Wnt signaling through impaired degradation of {beta}-catenin. We propose that functional effect of mutations associated with human diseases should be investigated at isoform- rather than gene-level resolution. Copy rights belong to original authors. Visit the link for more info
In 2005, acclaimed nature journalist and author Richard Louv coined the expression, "Nature Deficit Disorder," in his best-selling book, Last Child in the Woods: Saving Our Children from Nature-Deficit Disorder. The book sparked an international movement and greater awareness about the growing lack of human connection to the natural world. He discusses NDD and his new book, Our Wild Calling: How connecting with animals can transform our lives-- and save theirs released this week by Algonquin. According to the book jacket, Our Wild Calling makes the case for protecting, promoting, and creating a sustainable and shared habitat for all creatures. Louv suggests that strengthening the bonds we share with animals can help serve as an antidote to the growing epidemic of human loneliness. Louv is the cofounder and chair emeritus of the Children & Nature Network. animal care software peppermint narwhal iReinforce.com
Recebemos no Pulso o Valmir Tortelli. Ele é CEO da NDD e presidente do Orion Parque Tecnológico. No bate-papo o Valmir nos fala sobre seu case, como olha para o mercado, como trabalha a inovação e a cultura da empresa, enfim, um Pulso muito especial pra você se inspirar! Bora dar o play aí?
In this episode Michelle is joined once again by Erin Forward, MSP CCC-SLP, and they take on the beast of the change between the National Dysphagia Diet and the International Dysphagia Diet Standardisation Initiative. It is time! Erin and Michelle spend this fast paced hour updating and taste testing foods and drinks according to the new IDDSI guidelines! They will share their favorite IDDSI transition resources, as well as help to explain the differences in food and drink between NDD and IDDSI for all consistencies. Bring your private practice and personal practices in line with current best practice with this lively lecture! Also, be sure to check out the First Bite Insta and FB accounts for the videos of all the taste testing!
We are bathing ourselves in nature this week…camping, hiking and EATING - all of the things. Come get in-“tents” with us… Send us your stories: letseat@mikeyandrinnestayin.com Nature Deficit Disorder: https://www.psychologytoday.com/us/blog/people-in-nature/200901/no-more-nature-deficit-disorder Acupuncture for NDD: http://environmentalpediatrics.com Deck Farms: https://deckfamilyfarm.com/shop-online/ Thimbleberries:https://www.fs.fed.us/wildflowers/plant-of-the-week/rubus_parviflorus.shtml Huckleberry:https://en.wikipedia.org/wiki/Huckleberryletseat@mikeyandrinnestayin.com
Микшер Русской кибернетики 136 • 19 июня 2019 • Ведущий: Александр Киреев Автор гостевого микса: Андрей Руденко (КОРПУС 1, Омск) 01. LYMOU — Под одеялом 02. Pavel Kresling — Electric 4 03. King Shi — Temple Of Hope 04. Satori Summer — Shrink Into Yourself 05. AK-48 — Astrotravelin’ 06. NDD — То, что внутри 07. 02FC — Detroit. Become Acid 08. Random Unit — Drop It Immediately 09. satoruu — Don’t Look Into Your Eyes 10. The Foreign — Smile When It Hurts 11. Kirill Sawazki — New New Waves 12. Pyramid Blast — Youth 13. d3bAU4 — Sync (Triple Version) 14. Römin — Threshold Deviation 15. aspect245 — untitled3 16. Random Unit x Lewis Lane — Feel Something Друзья, открывайте для себя новую электронную музыку России, стран СНГ, бывшего СССР и восточной Европы вместе с национальным клубным проектом «Русская кибернетика» и его ведущими Евгением Сваловым (4Mal) и Александром Киреевым! Новые эпизоды «Русской кибернетики» вы всегда найдёте онлайн: Soundcloud: https://soundcloud.com/russiancyber/ Подкаст в iTunes: https://itun.es/i67C749 Яндекс.Музыка: https://music.yandex.ru/album/6917036 Mixcloud: https://www.mixcloud.com/4Mal/ Instagram с анонсами и эксклюзивами: https://www.instagram.com/ruscyber Сообщество в Фейсбуке: https://facebook.com/russiancyber Сообщество в ВК: https://vk.com/ruscyber Канал в Телеграме: https://t.me/ruscyber Анонсы в Твиттере: https://twitter.com/russiancyber Основные хэштеги для связи во всех соцсетях: #ruscyber и #русскаякибернетика Отправьте ваши треки в редакцию: http://promo.russiancyber.net/ Отправьте заявку на вечеринку «Русская кибернетика» или 4Mal DJ-сет: http://dj.russiancyber.net/ #modernrussianelectronica #makerussiagreatagain #house #deephouse #techhouse #progressivehouse #indiedance #nudisco #dj
Микшер Русской кибернетики 136 • 19 июня 2019 • Ведущий: Александр Киреев Автор гостевого микса: Андрей Руденко (КОРПУС 1, Омск) 01. LYMOU — Под одеялом 02. Pavel Kresling — Electric 4 03. King Shi — Temple Of Hope 04. Satori Summer — Shrink Into Yourself 05. AK-48 — Astrotravelin’ 06. NDD — То, что внутри 07. 02FC — Detroit. Become Acid 08. Random Unit — Drop It Immediately 09. satoruu — Don’t Look Into Your Eyes 10. The Foreign — Smile When It Hurts 11. Kirill Sawazki — New New Waves 12. Pyramid Blast — Youth 13. d3bAU4 — Sync (Triple Version) 14. Römin — Threshold Deviation 15. aspect245 — untitled3 16. Random Unit x Lewis Lane — Feel Something Друзья, открывайте для себя новую электронную музыку России, стран СНГ, бывшего СССР и восточной Европы вместе с национальным клубным проектом «Русская кибернетика» и его ведущими Евгением Сваловым (4Mal) и Александром Киреевым! Новые эпизоды «Русской кибернетики» вы всегда найдёте онлайн: Soundcloud: https://soundcloud.com/russiancyber/ Подкаст в iTunes: https://itun.es/i67C749 Яндекс.Музыка: https://music.yandex.ru/album/6917036 Mixcloud: https://www.mixcloud.com/4Mal/ Instagram с анонсами и эксклюзивами: https://www.instagram.com/ruscyber Сообщество в Фейсбуке: https://facebook.com/russiancyber Сообщество в ВК: https://vk.com/ruscyber Канал в Телеграме: https://t.me/ruscyber Анонсы в Твиттере: https://twitter.com/russiancyber Основные хэштеги для связи во всех соцсетях: #ruscyber и #русскаякибернетика Отправьте ваши треки в редакцию: http://promo.russiancyber.net/ Отправьте заявку на вечеринку «Русская кибернетика» или 4Mal DJ-сет: http://dj.russiancyber.net/ #modernrussianelectronica #makerussiagreatagain #house #deephouse #techhouse #progressivehouse #indiedance #nudisco #dj
Микшер Русской кибернетики 136 • 19 июня 2019 • Ведущий: Александр Киреев Автор гостевого микса: Андрей Руденко (КОРПУС 1, Омск) 01. LYMOU — Под одеялом 02. Pavel Kresling — Electric 4 03. King Shi — Temple Of Hope 04. Satori Summer — Shrink Into Yourself 05. AK-48 — Astrotravelin’ 06. NDD — То, что внутри […]
Dr. Matthew Worth discusses what exactly a neuro-developmental disorder is and his success with working with these patients. For more information on Dr. Worth's upcoming course, Neuro-developmental Disorders, visit carrick.us/NDD You can find Dr. Matthew Worth at http://mobrainandspine.com/
In this episode, Ben and Kristina anticipate springtime in Washington, DC, which means advocates from across the country are in town to meet with their members of Congress, and discuss updates related to unrelated business income tax, charitable giving, and government spending. Ben Corb, director of public affairs at the American Society for Biochemistry and Molecular Biology and co-chair of NDD United, joins as a guest to discuss what nonprofits should know about nondefense discretionary (NDD) funding efforts, how decisions on federal spending affect the mission of nonprofits across the country, and how they can get involved. About the Podcast Voices for Good is Independent Sector’s policy podcast for nonprofits, foundations, and anyone advancing the common good.
Bennett L. Leventhal, MD. Department of Psychiatry, UCSF. Clinical Director, STAR Center for ASD and NDD. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 32208]
Bennett L. Leventhal, MD. Department of Psychiatry, UCSF. Clinical Director, STAR Center for ASD and NDD. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 32208]
Bennett L. Leventhal, MD. Department of Psychiatry, UCSF. Clinical Director, STAR Center for ASD and NDD. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 32208]
Bennett L. Leventhal, MD. Department of Psychiatry, UCSF. Clinical Director, STAR Center for ASD and NDD. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 32208]
In this podcast, Dr. Alison Christy interviews Pradip Kamat from Emory University about his article, Outpatient Procedural Sedation of Patients With Autism Spectrum Disorders for Magnetic Resonance Imaging of the Brain Using Propofol. She also interviews Melissa Svoboda from Baylor College of Medicine in San Antonio. For more information on NDD, please click here.
Emily Prentice is a Neuro-Development Delay Therapist with Early Roots. She brings a wealth of knowledge to the table in this episode, helping us to understand why the development of reflexes is important not just in infancy, but in utero as well. We discuss what can happen when reflexes aren't developed properly, as well as what happens when infant reflexes are retained. Emily can be reached at emily.m.roper@gmail.com, or visit her website at www.earlyrootstherapy.com to find out more information.
NDD and RBJ join me for the second ever live episode
Been feeling a little low lately? Like something's missing in your life? Perhaps you've got a case of NDD! In this episode we explore the growing phenomenon known as "Nature Deficiency Disorder" starting with the future of our public lands... kids!
This week welcome to the show Dr. Dale Bredesen. Dr. Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO. The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explains the erosion of memory seen in Alzheimer’s disease, and has opened the door to a new therapeutic approach. He has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost. This model is contrary to popular dogma that Alzheimer’s is a disease of toxicity, caused by the accumulation of sticky plaques in the brain. Bredesen believes the amyloid beta peptide, the source of the plaques, has a normal function in the brain — promoting signals that allow some of the nerve connections to lapse. Thus the increase in the peptide that occurs in Alzheimer’s disease shifts the memory-making vs. memory-breaking balance in favor of memory loss. This work has led to the identification of several new therapeutic candidates that are currently in pre-clinical trials. Dr. Bredesen’s novel insights into the fundamental nature of Alzheimer’s disease recently attracted an investment of $3.5 million toward a $10 million goal for initial clinical trials of these new therapeutics. This generous support came from the private venture capitalist Douglas Rosenberg, who is helping to fund the Alzheimer’s Drug Discovery Network, centered at the Buck Institute. The unit is screening drug candidates to find those that can preserve a healthy balance in the signaling pathways that support memory. Dr. Bredesen’s work on nerve cell signaling is also the focus of a collaboration between the Buck Institute and BioMarin Pharmaceuticals, Inc., which is seeking treatments for a rare form of Alzheimer’s disease, early onset Familial Alzheimer’s Disease (eFAD), which may develop in people as young as 30 years of age. Questions we ask in this episode: In your opinion, what causes the onset of neurodegenerative diseases? Are they as common as we are led to believe, and should we be worried? How do we test for NDD? Is alzheimer's preventable/reversible, if so what steps should we take? How important is the role of nutrition and/or functional medicine in the prevention of NDD? Try a Free Sample of 180 Superfood Protein Blend: http://180nutrition.com.au/free-sample We have Dr. Dale Bredesen on the show. I’ve got to just say, it never ceases to amaze me some of the information that comes out on these podcasts. I just feel like the luckiest guy alive sometimes. There’s one that myself and Stuart love today. Dale was just a champion. We get into neurodegenerative diseases today, as that’s Dale’s area of expertise. He is a internationally recognized expert in the mechanisms of neurodegenerative diseases, such as Alzheimer’s disease. [00:01:00] He’s also come out with a new book, which is a New York best seller, The End of Alzheimer’s. It was an instant New York Times success. Now the book, as well, is covering this groundbreaking plan to prevent and reverse Alzheimer’s disease. That fundamentally changes how we understand cognitive decline. But there are so many valuable lessons within this podcast for all of us, whether we know anyone with a neurodegen- … I can’t even get the words out, neurodegenerative disease, or not. [00:01:30] Yeah, just get into it. Enjoy it. There’s quite a lot of technicality in here as well, but it’s definitely worth a couple of listens. If you know anyone that is suffering from neurodegenerative diseases, then please share this podcast with them, because I think there’s definitely hope. This podcast will inspire them. It was just, yeah, phenomenal, and I’m keen to try and get this message far and wide. [00:02:00] The last thing I want to say before we go over to Dale is that if you are enjoying the shows, guys, I would love you to leave a review, five star it, and subscribe it, just to continue to help us get this word out there. I think we’re three reviews short of 100 reviews for here in Australia or anywhere. That’s fantastic. If you could be one of those three to get us over the line, that would be brilliant. Anyway, let’s go over to Dr. Dale Bredesen. This podcast is awesome. Enjoy! [00:02:30] Hi, this is Guy Lawrence. I’m joined with Stuart Cooke, as always. Good morning Stuart. Stu Hello. Guy Our awesome guest today is Dr. Dale Bredesen. Dale, welcome to the show. Dr. Dale Thanks very much for having me. Guy Look, it’s fantastic, mate. We always kickoff and ask the same question to all our guests when they come on the show. That is, if a complete stranger stopped you on the street and asked you what you did for a living, what would you say? Dr.Dale I do everything possible to see if we can improve people who have neurodegenerative illness. [00:03:00] Guy Beautiful, perfect. I couldn’t say it any better. The other thing we always ask as well, Dale, is, would you mind just filling us a little bit in of your journey, your background, and what led you to be so passionate about this work, and making waves in the industry? Dr. Dale [00:03:30] Yeah. I came from a different place than most people who are doing this sort of medicine today. I came from a very classical science background. I was interested in mathematics and chemistry when I was a kid. I went to Caltech, and spent time at MIT as well for those reasons, working in chemistry. And then decided that if we were going to do something … I got very, very interested in the brain. When I was a freshman in college, I read a very interesting book called The Machinery of the Brain. I got very excited about that and kind of got hooked for life on neuroscience. [00:04:00] But I realized that if I was going to make any inroads into the illnesses that affect the brain, I really needed to go to medical school. So I went to medical school and got a lot of criticism for being a scientist wanting to go to medical school. But I went into neurology, and as you know, neurology has a long history of being tremendous diagnosticians. And, of course, Sherlock Holmes was actually based on a real neurologist. But in general, neurologists have been known to be the group that does not do much about the treatment side, very good with diagnosis, not so great, not so successful with treatment. And the diseases, no question, they’ve been very, very difficult. Full Transcript & Video Version: http://180nutrition.com.au/180-tv/dale-bredesen-interview/
Episode 44 – How to Trade Elections The Blokes hit the ground running with a breakdown of different broker types. Following the collapse of FXCM after their dodgy claims to be a ‘No Dealing Desk’ broker, The Blokes explain exactly what DD, NDD, STP, DMA and ECN all mean! After your morning dose…
I knew this was going to be an insightful interview, because Guy had already laid down the parameters of his argument: In just 10 years time humanity would become extinct on our planet. In the intro before we went to air - I asked Guy if he was open to me looking at ALL possibilities and to even humour me in my indulgences. So read on dear reader - this is a very unique interview and I will summarise what subjects I was unable to totally cover at the end. I knew this was going to be an insightful interview, because Guy had already laid down the parameters of his argument: That in 10 years humanity on our planet would become extinct. Well, I am 12 years older than Guy and have heard statements like this before... but 10 years! Then he opened the door to take him up on his following statement on his website: Nature Bats Last. (www.guymcpherson.com) As always, I’m open to alternative views. In fact, I’m begging for them, considering the gravity of this particular situation. I was ready for Guy, but I needed another hour to be able to build out a more compelling case for a global shift in consciousness. Or to at least seed the ideal. One of my first interviews (that I do not have a record of) was with NZ’s top scientist for 2004, Peter Barrett. At that time he was Director of the Antarctic Research Centre at Victoria University of Wellington. In his acceptance speech for the Marsden medal for exceptional scientific achievement he stated: “We have to change our ways because continuous growth and business as usual on our planet, will cause us to become extinct within the next 100 years." Well, the status quo in Wellington were not happy and he was asked to recant and offer up another statement, which he duly did, and stated: “the end of civilisation as we know it!" That same year I also interviewed James Lovelock, instigator of the Gaia hypothesis, that our planet is a super organism. He too implied that we had reached a tipping point. His two subsequent books The Vanishing Face of Gaia and The Revenge of Gaia were grim and pessimistic outlooks at what was happening due the sustained abuse and avarice that we humans have been engaged in, especially over the last 70 years in exploiting our great sustainer. He too said that we would not make it into the next century. He said “Enjoy life while you can. Because if you’re lucky, it’s going to be 20 years before it hits the fan.” That was early 2008, however he later stated in 2012 that he was an alarmist. He still maintains that by the end of this century 80% of the population will be wiped out. When hearing Guys pronouncement last week that "humanity would become extinct in 10 years time", I was already case hardened. As a ‘trooper’ it did not phase me - I was/am ready. I've been steeled for this since 1975, when I read the Doomsday Book by a Gordon Rattray Taylor. This book covered the fate of what we as a humanity were doing to our planet. In one nights reading it shocked the daylights out of me altering me substantially to this day. His foreboding narrative of the future of Planet Earth painted a collision course with the death of humanity, into a morbid, lifeless, Martian outlook. So I opened up with the recent Paul Henry morning TV3 show where ‘NZ’s loose canon and fervent denier of so many things’ was totally gob smacked. For this was the first time of hearing of his 10 years death sentence to his future dreams, unfinished diatribes and indulgences. He was like a goldfish blowing bubbles, yet looking very closely at Guy, you could see his eyes intently staring out at the world. The original 4 minute sound bite interview turned into a 10 minute one, as Paul wavered all breaks for advertising. He wanted more information about his starkly shortened future! In short, Guy maintains that planetary temperatures are all locked in already. We have blown the thermostat of our planet and we can’t do anything now. It’s like giving the command for an oil supertanker that has been at top speed to stop! This takes something like 120 miles or so to bring it to a complete halt, as its momentum is so powerful. Guy encourages us to go back to the land, take action and protest this takeover, such as in South Dakota at Black Rock. “It’s the right thing to do”, he says. People today suffer from NDD or ‘Nature Deficit Disorder’. We have lost our connection and don’t know where much of our food comes from. Hence our lack of consciousness of our living planet. There are always consequences. Year after year we have failed to solve the problem of growth at all costs. Not to mention the poisons we produce due to extraction of resources from the bounty of the land we inhabit. We have had the warnings time and time again and we took no action. We have all been born into the situation to find we are now born into captivity! Lack of Connection Kevin says the 1% are not burdened with empathy, to care about what they do. It’s a huge social disconnection that when they make decisions, they hurt the world. My question to Guy: Do you think we have sociopaths running the high end of our planet? Yes, we have. He could argue that we are all part of the problem because we (in my words) have all become consumers, consuming ourselves and our common future. That basically 95% of us always vote on our bank balance and what’s in it for Me? Kevin then jumped in and stoically stated that he wanted to be the last person planting the last tree on our planet, before the lights go out. I then leapt in and said I would be there with him! Ready to eat of the fruit of that tree! We are Slow Learners Then I introduce the concept that: 50 Years ago we heard that we would destroy our civilisation possibly in around 100 years or so - if we did not change our ways. 20 years ago they revised it to possibly 40 years 15 years it was down to 30 years Now Guy today is saying about 10 years to go... It nearly rhymes with. 50 years ago the human race were only using 10% of their potential 20 years ago they then said it was 7% 5 years ago it was down to 5% 2 years ago it was we were only using 2% of our potential So we are using less and less of our potential … to find out we're using less and less of our potential … What is going to happen in 5 years time? Guy jumped in and said yes, we have totally lost our way. Changing the Whole Focus: From Disaster to Changing of Human Consciousness Without grinding into what is actually happening … temperatures rising, droughts, catastrophic events, etc. (I was even going to ask him about Geo engineering however our time was short and this is covered in my summary at the end.) I decided to beat a path to the inner self, to our potential as a human and what can we as a humanity do, seeing the situation in Guys words was so dire. Albert Einstein said that we cannot solve the problems with the same consciousness that caused them in the first place. Where do you see yourself in relationship to this Guy? And he says he is all for it, but we have not done anything about it. Next, Nikola Tesla said "when mankind starts researching the invisible he will make more progress in 10 years that he will have in the whole of civilisation". Guy says that there is a lot that we do not know, because it is invisible and we have not learnt enough to become more evolved. Tesla talked about the ‘luminous akasha’ as to where he tapped into Akashic Records . Akasha is a sanskrit word that Buddhists believe in “a permanency of records in the Akasa” and “the potential capacity of man to read the same". What do you think Tesla was saying here? (listen to the interview for more) We are one Molecular Unified Energy Field. What about the fact that our planet is one unified molecular field that we are all connected - you to me in the gigantic sphere of atomic frequency - the air molecules between us, our bodies and this building is all one field oscillating at a particular frequency. Guys says ‘that we are that.’ This is fact YES? We are “one field". We Humans are the Nerve Endings of Our Planet I mention that James Lovelock says that we humans are the nerve endings for Gaia, Mother Earth and that when someone stands up in the Amazon with a sign saying “No more deforestation!” they are a nerve ending telling the world that the Amazon is wanting help. Same for someone standing up in Palestine with a sign saying “We want Peace”. This again is another nerve ending communicating with all other nerve endings that we need to change, stop war and heal for Peace. Well the planet is inflamed and the ones who are hearing the Earth’s call and feeling this calling deeply, are coming in with compassionate mindfulness to be a part of ‘her immune response!" Guy says that he is open to a miracle - and that we need to ‘Passionately Pursue a Life of Excellence’ We have the saying the ‘anima mundi' which is Latin for World Soul? So for arguments sake we could be all connected at the energy unified field? We share the one breath - all of us. This is all unseen and is invisible. Kevin adds that the Nuclear power stations in the US are still going and there are dangers of invisible radiation escaping. The US government has now extended the power station’s licenses by many more years. Even though virtually all have passed their use by date. They are now extremely dangerous because the cost of decommissioning them is outrageously enormous. The Japanese reactors at Fukushima are equally dangerous because they have been idle and out of action for 5 years. They are now being recommissioned, and this is fraught with problems. Guy says of Tesla and regarding ‘the invisible' that there is so much we do not know. He talks of 'dark matter' and that science is now recognising there are many other Universes other than our own. It’s a Multi verse. And he says about a change of consciousness - is there enough time for a change of consciousness? … Mass consciousness? He says he does not know, but is open to it for sure. Also mentioned are Walter Russell (the American mystic) and Viktor Schauberger, who have seen into the invisible. Schauberger, (known as the 'father of water'), was able to lie down beside rivers and ‘become one with them’ in consciousness. Meditation was mentioned as a way of being able to find solace from the outside world as well as heal from grief, which is what many people are experiencing as we learn of the plight of our home planet, mother earth. The conversation then moves to Elisabeth Kubler-Ross where 1600 people came to listen to her tell of her research at the Auckland Town Hall. She had interviewed 20,000 people who had had ‘near death and out of the body’ experiences that we were more than a mere body. This was to extend the conversation beyond the limitations of seeing the world from a 3 dimensional world devoid of spirit or soul. That there is far more to existence than this world of the so called 5 senses. I mention names like: Drs. Kenneth Ring Drs. Raymond Moody Ian Stevenson University of Virginia Who have all studied death and Guy agrees that death and dying plus sex are taboo subjects. Also there are books like Super Nature - Dr Lyall Watson, prolific author of many books on life The Secret Life of Plants and the Secrets of the Soil by Peter Thompkins & Christopher Bird. These books on nature extend our knowingness about how ‘alive’ nature is. And we are now running out of time, to extend our view of the human capacity to learn and grow. Guy says that finding joy and to be open to allow joy to find us is so important. Find your tribe. Go back to grass roots working with your neighbourhood. Pursue excellence. These are the best things we can do at present. Guy says that extinction is a natural process and we are in the 6th great extinction. Kevin says, that now he knows his time is limited, it has freed him up immensely. He can do far more things that benefit the community that he is part of, on the island that he lives on. And there is no better time than the now. Guys says, if we had made the change during the cultural or flower power revolution in 1966-67 it may have made a difference to the world if it had spread. However, our children and grandchildren are not being factored into our future. This interview covers many other heartfelt subjects and is well worth the listen as it is sprinkled with little gems. In Summary: So that was it, we ran out of time. However, I also wanted to cover the other unknowing capacities of the human being such as: The story of savants There was the 'Mega Savant' Kim Peek, best known by the movie character he inspired the “Rain Man” played by Dustin Hoffman in the 1988 film of the same name. Fast absorption was no problem for Peek, who could just as easily read and memorise a telephone book as a compendium of Shakespearean plays. Kim could take in 10,000 words-per-minute reading two pages at a time—the left page with his left eye and the right page with his right eye. If a human can do this, can not any other human, once we tap into that aspect of our psyche? Then there was fire walking - Fijians and Indians in South Asia and their diaspora in Sri Lanka, Mauritius, Réunion, South Africa, Malaysia and Singapore, who celebrate the Thimithi festival. David Willey, professor of physics with the University of Pittsburgh, says he believes fire walking is explainable in terms of basic physics and is not supernatural nor paranormal. Willey notes that most fire walks occur on coals that measure about 1,000 °F (538 °C), but he once recorded someone walking on 1,800 °F (980 °C) coals. Mind over matter? What about Speed reading? Anne Jones, six times World Speed Reading Champion told the Guardian media that most of the time, she reads at speeds between 800 and 1,500 words per minute. This is much higher than the average for a good reader given by fellow academics, of 200 to 400 words per minute. Theodore Roosevelt Theodore Roosevelt was among the most intelligent U.S. Presidents and famous for his efficient reading skills. He would often take in an entire book before breakfast. If time permitted after dinner, he’d read through a few more before bed. Then his relative, President Franklin D. Roosevelt Inspired by his fifth cousin, Franklin D. Roosevelt adopted old Teddy’s auto didactic approach and taught himself to speed read. He began by fixating on two-to-three words at a time. He then pressed on to three-to-four, six-to-eight, and so on. Eventually, America’s beloved four-term President could read whole paragraphs like ordinary folks read individual words. Following in the Roosevelt’s footsteps, President John F. Kennedy made speed reading a personal priority during his tenure in the White House. With practice, he cultivated a rate of 1,2000 wpm, as he wanted to be able to read two or three books daily. JFK wanted his brother Bobby to learn to speed read, too, and the pair of Kennedy’s took classes together to that end. So what is the capabilities of the human mind? This is the never ending question. I also had many other questions about some yogi’s in India that I wanted to talk about. Information that’s not publicised in the main stream media such as Paramahansa Yogananda and his astounding death. ET Intervention? Plus, in my pre-talk with Guy before the interview, I did even mention to him the ET situation. Captain Edgar Mitchell (6th man to walk on the moon) mentioned on Campbell Live here in Auckland in 2008 that the US authorities have bodies and that they have been studied. So there is most definitely an Extra Terrestrial equation that has to be at least discussed. If our planet is in free fall and losing it and they have super energy technologies that can reverse all the heating and reflect sunlight back into space... They could have reason to push into our world, defying the prime directive not to intervene in another planet’s evolution, however again I ran out of time to bring this subject back up. Post Thoughts on 10 years or not? With the subject based on only 10 years to live as a species, I personally have another slightly optimistic opinion. The Antarctic ice is close to 1.9 km (1.2 mi; 6,200 ft) in thickness and covering an area of almost 14 million square kilometres (5.4 million square miles) containing 26.5 million cubic kilometres (6,400,000 cubic miles) of ice. It will take a long time to melt, as it is in darkness and cold for 4 to 6 months a year. And Greenland has a mean altitude of ice at 2,135 metres (7,005 ft). The thickness is generally more than 2 km (1.2 mi) and over 3 km (1.9 mi) at its thickest point and covers an area of 1,710,000 km2 (660,000 sq mi). And yes there is the slowing down of the Atlantic ocean gulf stream too. There are many, many other contingencies to play out before I adhere to Guys 10 year statement, though he has far more up to date information than I. I remain confident that I am still going to enjoy a long life of a degree of happiness, bearing in mind we are in such a majorly critical evolutionary phase. Yes, Geo Engineering! I was going to ask Guy about what is happening about Geo Engineering. (geoengineeringwatch.org) I see there is a large in-house disagreement between them and Mr.G Edward Griffin of ‘What in the World Are They Spraying?’. However as this is still unclear - I decided against it. Yes we live in very interesting times!
Hello, everyone! I'm your host and sommelier of Succotash, the Comedy Podcast Podcast, and this is the official blog post accompaniment to Epi86. Before i get into the bulk of what this patest show is about, let's just take a moment out to consider that, in the midst of scraping this episode together, I found out that I have just won the first place award for an editorial cartoon I did this past year for the Half Moon Bay Review, the 100+ year old newspaper serving the Coastside community about 30 miles south of San Francisco. Yay to me. I've been doing the editorial cartoon - which I call a "phodoodle" because of the technique I use in putting it together with bits and pieces of various photos, then creating a more hand-drawn look to the results - week in and week out, for over a decade for the Review and this is the first year that the California Newspaper Publishers Association has so honored me, so I'm pretty jazzed! I'm republishing the award-winning 'toon here. Why? And what does that have to do with this podcast? Nothing, really. But who else am I going to share that kind of news with, right? 3 Still Standing Another thing that has little to do with this podcast in particular happens THIS Friday, May 9th, when yours truly will be hosting a Comedy Event. If you're in the San Francisco Bay Area, you're in range to hit the 142 Throckmorton Theater in Mill Valley, a stone's throw from San Francisco. That's where we're doing a benefit for a new documentary, 3 Still Standing - which I've mentioned on the show before - to help the filmmakers finish production on the movie. It looks at the San Francisco comedy boom of the 1980's by following the careers of three local comedians: Larry "Bubbles" Brown (a former Succotash guest), Johnny Steele, and our own Will Durst. The three guys will be performing during the show and the filmmakers, Robert Campos and Donna LoCicero, will be answering questions from the audience. You can get more info, including showtime and ticket links, at https://www.facebook.com/3StillStanding. Empty Coffers We just got our monthly statement as an Amazon Associate and it seems we made ZERO money from our Amazon portal at the top of our homepage this past month. Which means I need to start mentioning it more until you guys remember to click on the banner at the top of the page that takes you directly to Amazon, where you can do your shopping as usual. With no skin off your nose, Amazon then tosses us back a few quatloos which we use for equipment, monthly fees to Libsyn, our delightful web hosting service, and gin. In brief, that’s http://SuccotashShow.com to Amazon -> buy your stuff -> money back to us for new mics, web rent, and gin. Got it? Good! Bursts O' Durst Again this show I feature a Double Dose of Durst, since we missed a week somewhere between the last episode and now. So listen for Will Durst early in the show and then, again, toward the end. Ahoy, Mateys! We'll be serving a dessert course this episode! Just stay tuned after Bill Heywatt's closing credits to hear my narration for part of Epi10 of HMS Codcast, written and produced by Nigel Boydell. It was a blast to do, especially because I do several different voices, and whole rollicking seagoing chapter awaits at the very end of the show. (You can also click this link to be whisked to Nigel's Uncle Arthur's Collection of shows.) The 10 Most Active Shows in Stitcher's Top 100 Comedy Podcasts List In case you’ve forgotten or if you’ve never heard this feature before, we look at the ten podcasts that have moved up or down the Stitcher Top 100 Comedy Podcast chart in the past week. AT MOVED 10 How Did This Get Made? +1247 The Artie Lange Show +1053 Bertcast’s Podcast -1461 The Cracked Podcast +962 What About Pod? -1680 The New York City Crime Report w/Pat Dixon +7 89 The Dead Authors Podcast +2390 How Was Your Week with Julie Klausner -1092 Foreally Show w/ Rude Jude & Senim Silla +86100 Beats & Eats +9 The Clips Oh, My. God. Do we have clips for you this episode. That's not a question, it's a statement. Thanks to the herculean efforts of our Associate Producer Tyson Saner, I have clips coming out of my ears this time around (very appropriate for an audio medium), which means you do, too. In fact, between the clips and the special HMS Codcast episode at the end, I believe this is the second longest Succotash episode in our 3 year history. Chillpak Hollywood HourCongrats to Dean Haglund and Phil Leirness, the Ozzie & Harriet of Podcasting, as they observe their 7 years in the medium! The clip from this show is from the last of their Year 6 'sodes where they, as usual are mentioning Succotash mentioning them mentioning us and so on. As I mention in this episode, they've in the process of editing their newest feature film, a potboiler of a thriller with some comic overtones (undertones?), The Lady Killers! And here's their first trailer for the movie: The Carson PodcastI love the premise for this next and relatively new podcast. The Carson Show is an example of how podcast DOES have something for everyone. Host Mark Malkoff talks with guests about legendary talk show host Johnny Carson. That’s it. That’s the core premise of the show! Guests include stand-up comics who debuted on The Tonight Show Starring Johnny Carson, individuals that worked on the show, frequent guests, and top entertainers that were influenced by Carson. In the first dozen episodes, Malkoff has interviewed Carol Burnett, Byron Allen, Martin Mull, and Dick Cavett. Tyson clipped Epi3 which features one of of my absolute favorite and highly underappreciated actors: Charles Grodin. The Bob Zany ShowI got a note this past week from Erin O’Connor, who started out as a standup in San Francisco and has been in LA for ever so long. She started co-hosting The Bob Zany Show a number of months back and she thought we’d enjoy the conversation that she and Bob Zany had with Ella James, a voiceover actress and comedy transplant from Australia. The Church of What’s Happening NowThe clip of The Church of What’s Happening Now is from their Epi159. Comedian Rick Ramos (host of Watch This) joins Joey Diaz and Lee in studio. Although this show included comedy manager Barry Katz calling in for one of the best calls in the shows history, the clip that Tyson got caught the moment that the recent earthquake hit in LA as they were recording. Small Town BringdownBranden Grieder and Elliot Drew have spent their entire lives podcasting. But up until, 2011, they had never actually recorded themselves talking to each other. That has all changed. Listen in as they talk shit about shit weekly and that includes the clip we got. Positive Push with Brody StevensI think Brody Stevens is hilarious, personally. He’s got a podcast called The Steven Brody Stevens Festival of Friendship but he’s also got a videocast which is live on Tuesday at noon on VPN – the Video Podcast Network. He welcomes comedians, athletes, and friends to discuss positive energy, bike riding, supplements, and more! Our associate producer Tyson Saner grabbed some audio featuring Brody and guest Brian Redban. Modern Day Philosophers with Danny LobellWe clipped Modern Day Philosophers with Danny Lobell not too long ago – at least as far as our episodes go – but recently he had a friend-of-Succotash on: Rick Overton. Not only is Rick a guest on this episode but he also helped Danny move a couch before the show started. So they talk about that in addition to, I think, Plato. Team Coco PodcastEvery week, according to the Team Coco podcast website, host Aaron Bleyaert hunts down and hog-ties a new celebrity or CONAN staffer to interrogate them about their jobs, what's in their pockets, and everything in between. It's the ultimate glimpse behind the scenes… except, you know, you take it with your ears. This clip he talks to Comedy Bang Bang's Scott Aukerman about what it was like shooting the Zach Galifianakis web series Between Two Ferns with guest and President Barack Obama. The Inverse Delirium PodcastIt was with a heavy heart that I cued up this clip, an Exorcist spoof from The Inverse Delirium Podcast. I say that because host host and creator of the Inverse Delirium, Geoffrey Welchman, sent me a direct message on Twitter a couple of days ago saying he was shutting the show down after 4 years. I asked why and he said between his day job and other demands eating into his time and the fact he has “lost the spark”, as he put it, to get behind the show, he thought it was time to sign off for the last time. I predict he’ll be back. Until then, here’s what may be the last clip we play on Succotash from our friend Geoffrey. So long, Geoffrey! You’re a credit to the industry and your show will be missed. The ChampsIn a clip from a February episode of The Champs with Neal Brennan & Moshe Kasher – a couple of very funny comedians who somehow manage to find the time to record these podcasts together on a regular basis – they interviewed Arsenio Hall, whose new TV show was recently picked up for a second season. He talks about when it was that he first realized he wanted to entertain people. The Doghouse Bastards or DHB Radio ShowI’ve had the Doghouse Bastards (or DHB Radio Show) talked up be a few folks, including last episode’s special guest host Davian Dent. The host, Scott Taylor Scott, is from Scotland. I’m not sure about the Lurch Monster and NDD. But in this clip from show #159 “She’s Trying To Kill Me”, they mourn the loss of the WWE’s “Ultimate Warrior.” The TravisphereAccording to the Podcast Summary as stated on the homesite of this next podcast: “The Travisphere is a glimpse into the world of Travis Knight, so give a listen for a few laughs, great stories, absurdity and whatever the hell else he wants to talk about.” His guest in this clip is none other than Twittizen Tom Jackson Jr., who is a retweeting mofo that has given Succotash a great deal of love. But we’re obvious not the only target of Tom’s affection, as Travis describes him as one of his “awesome followers.” Get Up On ThisFrom the bottomless SModcast network comes Get Up On This with Jensen Karp, once known as "Hot Karl" as a white rapper at the same time as Eminem's rise to fame, and Matt Robinson, best known for co-writing and co-directing The Invention of Lying movie with Ricky Gervais. They and their weekly guests tell you what you need to know about before whatever it is their talking about gets big. This clip features guest Beth Sterling. Duncan Trussell Family HourThe description for The Duncan Trussell Family Hour, which we’ve featured before, calls it “a weekly salon-style supershow, where comedian Duncan Trussell and guests explore the outer reaches of the multiverse.” Tyson grabbed us off a hunk of Duncan’s 100th episode, where he reunited with Natasha Leggero, his former co-host of a podcast called The Lavender Hour (of which there are 60 episodes on iTunes.) Comical PodcastComical Podcast is a comedy show about comic books hosted by two moderately funny guys from Houston, Texas. Justin and Miguel take the lead with various guest stars including (most commonly) Justin’s wife, Heather. The guys have been fans of comic books most of their lives and have been listening to podcasts for the last few years. It took some time and some convincing, but they've finally started their own show and it's gone great so far. This clip is from Epi10 “You Drop Your Pants, I'll Rip Mine...” Matt & Corey Talk Too MuchMatt and Corey, of Matt & Corey Talk Too Much, asked if we’d clip them on the show. So Tyson obliged them by grabbing a slice off of their bonus episode, Epi18 where they talk about some horrible hillbilly accident involving a broken floorboards and a purple dildo. (Incidentally, Tyson informs me that this is the first show that he’s lifted from http://Spreaker.com - says it appears to be similar to Soundcloud.) That’s it for Epi86. As I mentioned above, I believe that was a record for number of clips played on this show. Big thanks again to our associate producer Tyson Saner for collecting most of those. And a big thanks to YOU for downloading or streaming this podcast. If you liked any of what you heard in today’s clips, do yourself a favor and track down those shows and give them a full-on listen. Not only did I mention their homesites but you can find most of all of them on iTune, Stitcher, SoundCloud and wherever fine podcasts (and otherwise) are located. If you get a chance to shop Amazon, please use the banner at the top of our homepage to do it. Or visit http://SuccotashShow.com and click on the Donate button to shovel us a buttload of cash that you're not using any more. Please don't forget to pass the Succotash! — Marc Hershon
High serum uric acid (UA) levels are associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. It is largely unknown whether there are gender-specific differences regarding the association between UA and prediabetic states. We examined the possible association between UA levels and known as well as newly diagnosed diabetes (NDD), isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and combined IFG/IGT in a population-based sample of 32-to-81-year-old men and women. An oral glucose tolerance test was carried out in all 2,740 participants without known diabetes of the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study conducted between 2006 and 2008 in Southern Germany. Serum UA was analysed by the uricase method. In women after multivariable adjustment the associations between UA and i-IFG (OR 1.57, 95% CI 1.15-2.14), IFG/IGT (OR 1.52, 1.07-2.16), NDD (OR 1.67, 95% CI 1.28-2.17), and known diabetes (OR 1.47, 95% CI 1.18-1.82) remained significant, but the association with i-IGT (OR 1.14, 95% CI 0.95-1.36) lost significance. In contrast in men, after multivariable adjustment there was only a significant association between UA levels and i-IFG (OR 1.49, 95% CI 1.21-1.84), all other associations were non-significant (i-IGT: OR 1.09, IFG/IGT: OR 1.06, NDD: OR 0.91, known diabetes: OR 1.04; all p-values>0.05). Serum UA concentrations were associated with different categories of impaired glucose regulation in individuals from the general population, particularly in women. Further studies investigating the role of UA in the development of derangements in glucose metabolism are needed.
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