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Send us a textEpisode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA may reduce inflammation by modulating immune cells in the meninges, offering potential therapeutic benefits.About the guest: Michael Wheeler, PhD is an Assistant Professor of Neurology at Harvard Medical School. His lab studies how immune responses influence behavior, mood disorders, and addiction.Key Conversation Points:The blood-brain barrier (BBB) is not as impermeable as once thought, allowing immune signals like cytokines to influence brain function even in healthy states.Chronic stress can weaken the BBB, increasing inflammation and affecting mood-regulating circuits, potentially contributing to depression.Microglia, the brain's resident immune cells, help maintain neural circuits by pruning synapses and regulating metabolism.Psychedelics like psilocybin and MDMA can reduce inflammation by prompting immune cells (monocytes) to leave the meninges, potentially via vascular effects.These psychedelics may act in a context-specific “window,” requiring a dysregulated tissue state to exert anti-inflammatory effects, not as broad-spectrum anti-inflammatories.Neuroinflammation may underlie some treatment-resistant depression cases, suggesting immunotherapy could complement traditional psychiatric treatments.The brain encodes peripheral immune signals, like gut inflammation, in specific circuits, which can “remember” and recreate inflammatory responses.Aging may naturally increase blood-brain barrier leakiness, heightening the brain's susceptibility to peripheral inflammation.Future research aims to explore how psychedelics influence plasticity and their potential in treating inflammation-related diseases beyond psychiatry.Related episode:M&M 2: Psilocybin, LSD, Ketamine, Inflammation & Novel Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts
Send us a textEpisode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells' sensitivity to omega-6 fats; differences between breast cancer subtypes; broader implications of dietary balance for health.About the guest: John Blenis, PhD is a Professor of Pharmacology at the Meyer Cancer Center at Weill Cornell Medicine. Nikos Koundouros, PhD is a postdoctoral fellow in Blenis' lab.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Key Points:mTOR pathway acts as a cellular “brain,” sensing nutrients like amino acids, glucose, and fats to regulate growth. Its dysregulation can drive cancer.High dietary omega-6 fatty acids, like linoleic acid found in seed oils, can fuel triple-negative breast cancer growth by activating mTOR.FABP5, a lipid chaperone protein, is overexpressed in triple-negative breast cancer, making these tumors more sensitive to omega-6 fats, suggesting its potential as a therapeutic target.Modern diets with high omega-6 to omega-3 ratios disrupt inflammation balance, unlike historical 1:1 ratios, potentially increasing cancer risk.Genetic variations and cancer subtypes highlight the need for tailored dietary recommendations, as blanket nutrition advice may not suit all patients.While omega-6 fats exacerbate existing triple-negative breast cancer, their role in initiating cancer remains unclear, requiring further study.High omega-6 intake may influence other cancers (e.g., prostate, colon) and chronic diseases like obesity, linked to FABP5 and inflammation.Related episode:M&M 200: Dietary Fats & Seed Oils in Inflammation, Colon Cancer & Chronic Disease | Tim Yeatman & GaneSupport the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts
Send us a textEpisode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus's role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidation, glucose regulation, and metabolic health, challenging conventional neuroscience assumptions; the interplay of brain rhythms, sleep, and preconfigured neural dynamics; the history and conceptual foundations of neuroscience; and more.About the guest: Gyorgy Buzsaki, MD, PhD is a professor at NYU. He leads a lab investigating how neural circuits underpin cognition, particularly through oscillations and brain-body interactions. His work has significantly advanced understanding of memory formation and spatial navigation.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Key Conversation Points:Hippocampus isn't just for memory or navigation; it may orchestrate action planning and abstract representations of the world, shaped by evolutionary constraints.Brain rhythms, like sharp wave ripples, synchronize neural activity, enabling efficient communication and impacting bodily functions like glucose homeostasis.Sharp wave ripples, prominent during non-REM sleep and consummatory states, are critical for memory consolidation and may link sleep disruptions to metabolic disorders.Buzsaki challenges the idea of memory as fixed synaptic patterns, proposing it's more like dynamic, cloud-like sequences, endlessly reconfigurable.The brain's intrinsic dynamics prioritize action generation and learning from consequences over external representations.Related episode:M&M 16: Sleep, Dreams, Memory & the Brain | Bob Stickgold*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts
Send us a textThe biophysics of life, exploring how light & energy shape biology, with biophysicist Dr. Nirosha Murugan.Episode Summary: Dr. Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light environments on health; her work inducing limb regeneration in frogs using silk hydrogels and growth factors; cancer as an energetic dysfunction; potential of non-invasive photonic diagnostics; the need for new tools to study these phenomena.About the guest: Nirosha Murugan, PhD is a biophysicist and assistant professor at Wilfrid Laurier University in Waterloo, Ontario. Her lab investigates the biophysics of life.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Key Conversation Points:Cells emit biophotons, ultra-weak light tied to metabolism, which may carry information for processes like immune response and neural communication.Microtubules might function as biological fiber optics, potentially guiding light within cells for signaling purposes.Red and near-infrared light can accelerate wound healing and reduce inflammation, likely by modulating mitochondrial activity.Cancer cells emit distinct photonic signatures, which could enable non-invasive diagnostics by detecting light differences from healthy tissues.Modern light environments, unlike natural sunlight, may subtly affect health by altering biological responses to electromagnetic signals.Biological systems act as metamaterials, patterning energy flow in ways that constrain and shape molecular and behavioral outcomes.Related episode:M&M 221: Regenerative Energy & the Light Inside You | Jack Kruse*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts
Send us a textShort Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain.About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Alex Kwan discusses how psychedelics like ketamine and psilocybin induce rapid neuroplastic changes in the brain, particularly in the prefrontal cortex, contrasting their effects with traditional antidepressants like SSRIs, and exploring their potential for treating depression and chronic pain through structural and functional brain alterations.Key Takeaways:Ketamine & psilocybin rapidly increase dendritic spine density in the prefrontal cortex, enhancing neural connections within days, unlike SSRIs, which take weeks.These drugs show sustained neuroplastic changes in mice, lasting weeks to months after a single dose, suggesting long-term brain rewiring.Serotonin 2A receptor is critical for psilocybin's neuroplastic effects, as precise genetic knockouts in adult mice eliminate spine growth.Unlike ketamine, psilocybin activates the insula, a brain region linked to chronic pain processing, hinting at new therapeutic potential.Both drugs induce similar gene expression patterns in areas like the prefrontal cortex and amygdala, but differ in specific regions like the insula.Related episode:M&M #30: Psilocybin, Ketamine, Neuroplasticity & Imaging the Brain | Alex Kwan*Not medical advice.Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off For all the ways you can support my efforts
This is recording 3 of 6 from a three-day meeting recorded on the 14th of May, 2000 in Coolangatta, Gold Coast, Australia. These materials were recently digitized and modernized from older formats after an extensive restoration process, and we are happy to offer them freely. The complete audio recordings from this meeting set will be made available later in the year in the subscriber-only podcast through Apple Podcast – https://podcasts.apple.com/us/podcast/the-barry-long-podcast/id1709595005 and Spotify – https://open.spotify.com/show/34rcMFK6b4CcicY7JDxo9fIn this episode, Barry describes the journey from attachment to detachment. He explains that while the beauty of existence — in flowers, the sea, and human love — is real and wondrous, it is attachment to form that causes suffering. Living the spiritual life leads to living the life divine — a state that occurs when one ceases to live from the self, and a greater intelligence begins to live through one. As this unfolds, true union — free of possession — becomes possible, and one draws to oneself one's perfect mate. Barry says – "...your whole life is about bringing her or him into existence. Not someone outside you. Not a dream. But the true woman, the true man, the divine principle behind the body. And no one else can do it for you. You must live, love, and surrender enough for your true mate to be made real in your life."Barry goes on to describe the nature of the self: a band within the psyche where emotions and attachments dwell. He says that human suffering arises from being possessed by negative emotions rooted in the psychic realm, accumulated over generations. By acknowledging the good in life, loving purely without attachment, and surrendering the selfish will, individuals gradually illuminate their perfect body — a deeper, divine something within the psyche. The true purpose of life, Barry says, is to light up this perfect body through love and detachment, by undergoing the circumstances of one's life rightly — by suffering rightly. In time, a moment comes when suffering is no longer needed, when the self falls away and the psyche stands purified — and what is is the life divine.~Extracts:"The first sign of the true love coming into existence is that you never, ever want to be apart. You never want to go anywhere alone, unless you have to, of course. Always together. Always. But if you want to go and be alone — if you want to go down to the football club or have a night out with the girls — well, you've got some time to keep going until you bring this extraordinary principle of woman or man into existence in a body.""When you're next angry, do you see that you're being manipulated? This is what we are talking about — starting to live the spiritual life — when you can see that your anger, your resentment, your negativity is not love but possession. Until you desist from being identified with these emotions, until you are purified of them, you cannot truly love or bring the perfect love into existence."~Further reading:
Send us a textShort Summary: The flaws of nutrition epidemiology with Dr. John SpeakmanAbout the guest: John Speakman, PhD is a professor at the University of Aberdeen and runs a lab in Shenzhen, China, focusing on energy balance, obesity, and aging. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. John Speakman explores the pitfalls of nutrition epidemiology, a field that links diet to health outcomes like cancer and obesity but often produces contradictory results. They discuss flawed methods like 24-hour recalls and food frequency questionnaires, which rely on memory and are prone to bias, and introduce Speakman's new tool using doubly labeled water to screen implausible dietary data. The conversation highlights systematic biases, such as under-reporting by heavier individuals, and emerging technologies like photo diaries and AI for better dietary tracking.Key Takeaways:Nutrition epidemiology studies often contradict each other due to unreliable methods.Common techniques like 24-hour recalls & food frequency questionnaires suffer from memory issues, portion size issues, and systematic biases, often underestimating food intake.Heavier individuals (higher BMI) under-report food intake more, skewing associations between diet & obesity.Speakman's tool, based on 6,500 doubly labeled water measurements, predicts energy expenditure to flag implausible dietary survey data.Emerging technologies, like smartphone photo diaries and AI food identification, promise more accurate dietary tracking than traditional surveys.Randomized controlled trials, not surveys, provide the most reliable dietary insights; single-day intake surveys linked to outcomes years later are dubious.Speakman advises ignoring most nutrition epidemiology headlines due to their inconsistency and lack of prognostic value for behavior change.Related episode:Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: Cancer's metabolic roots with Dr. Thomas Seyfried.About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Thomas Seyfried discusses the mitochondrial metabolic theory of cancer, challenging the dominant somatic mutation theory. He explores how cancer cells rely on fermentation due to defective oxidative phosphorylation, drawing on Otto Warburg's work. Seyfried explains how ketogenic diets and nutritional ketosis can starve cancer cells by limiting glucose and glutamine, while sharing evidence from nuclear transfer experiments and clinical studies. The conversation also covers environmental factors driving cancer and the importance of metabolic flexibility for prevention.Key Takeaways:Cancer is characterized by dysregulated cell growth, but Seyfried argues it stems from mitochondrial dysfunction, not just genetic mutations.Cancer cells ferment glucose & glutamine, unable to use fatty acids or ketones, making ketogenic diets a potential therapeutic tool.Nuclear transfer experiments show cancer traits reside in the cytoplasm, not the nucleus, challenging the somatic mutation theory.Environmental factors like processed foods, stress, and poor sleep disrupt mitochondrial function, increasing cancer risk.Seyfried's glucose-ketone index helps monitor metabolic states to manage cancer & chronic diseases.Cancer rates are rising in younger people, possibly due to obesity, inflammation, and environmental toxins.Metabolic flexibility, cycling between ketosis and carb-based states, may mimic ancestral patterns and reduce chronic disease risk.Related episode:M&M #215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher.About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Matthew Budoff discusses cholesterol, heart disease, and his study on the ketogenic diet's impact on lean, metabolically healthy individuals with high LDL cholesterol. He explains LDL, HDL, and triglycerides, debunking myths about their direct link to heart disease, and emphasizes the importance of coronary calcium scans to assess plaque buildup. Budoff also covers statins, dietary cholesterol, and personalized heart health strategies.Key Takeaways:LDL cholesterol is not a definitive predictor of heart disease; plaque buildup, assessed via coronary calcium scans, is a better indicator.Lean metabolically healthy people on a ketogenic diet may have high LDL without increased plaque progression after one year.Coronary calcium scans, costing ~$100, are recommended for men around age 40 and women around 45-50 to evaluate heart disease risk.Statins effectively lower LDL and can reverse soft plaque, but may be overprescribed for those without plaque buildup.Dietary cholesterol has minimal impact on blood cholesterol, as the liver produces ~85% of it.Ketogenic diet can aid weight loss & diabetes control but may cause high LDL in some lean individuals, known as lean mass hyper-responders.Plaque progression depends more on existing plaque than LDL levels in metabolically healthy ketogenic diet followers.Heart health varies widely due to genetics and other unknown factors, underscoring the need for personalized assessments.Related episode:M&M #158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'AgoSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
If we have been crucified with Christ, we can confidently hope that we will also rise with Him. Jeff discusses the concept of an 'Easter Eulogy', examining Ephesians 1:3-14 to explore the spiritual inheritance and blessings Christians receive through Christ's resurrection. Jeff offers insights on how this inheritance can provide hope and encouragement, especially during challenging times. Snippet from the Show "All of the inheritance that Jesus has given us comes as a result of his suffering, death, and resurrection." Email us with comments or questions at thejeffcavinsshow@ascensionpress.com. Text “jeffcavins” to 33-777 to subscribe and get Jeff's shownotes delivered straight to your email! Or visit https://media.ascensionpress.com/?s=&page=2&category%5B0%5D=Ascension%20Podcasts&category%5B1%5D=The%20Jeff%20Cavins%20Show for full shownotes!
We're back with our April episode on Longlegs! This movie generated so much buzz and certainly did well at the box office last year, but what in the hell was going on in the movie? We try to parse the plot while constantly getting hung up on metal balls. Both of us agree that the atmosphere of this movie is great, there's a lot of things to like, but ultimately it didn't come together in the execution. Tangents include: Homeschooling and my size Barbie dolls.If you have seen Longlegs we would love to know what you thought about it! Let us know on social media or YouTube!Shoutouts:@rye_smile_filmsLonglegs (2024)Director: Osgood PerkinsTawny's rating: 1.75/5Felicia's rating: 3/5Send us a textSupport the showAll things TCHF: https://linktr.ee/twochicksandahorrorflickSupport the Show:Join our Patreon: https://www.patreon.com/twochicksandahorrorflickTCHF shop: https://twochicks.threadless.com/designs/podcast-cover-art/Connect with Us:Join our horror community on Discord: https://discord.gg/8WBByTQPFXWatch us on YouTube: https://www.youtube.com/@twochicksandahorrorflickFollow us on Social:Instagram: https://www.instagram.com/twochicksandahorrorflickFacebook: https://www.facebook.com/twochicksandahorrorflickTikTok: https://www.tiktok.com/@twochicksandahorrorflickTwitter: https://twitter.com/twochicksHF Send us your reviews, thoughts, and recommendations: twochicksandahorrorflick@gmail.com or visit our site https://www.twochicksandahorrorflick.com/
Send us a textShort Summary: The science of obesity and appetite regulation, blending genetics and neurobiology with practical insightsAbout the guest: Giles Yeo, PhD is a professor of molecular neuroendocrinology at the University of Cambridge. He leads a lab studying obesity and appetite regulation.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick interviews Dr. Giles Yeo about the genetics and neurobiology of obesity, starting with the discovery of leptin in the obese mouse model, detailing its role in appetite regulation via the hypothalamus, and discussing GLP-1 drugs like Ozempic for weight loss. It delves into how genetic factors, like the leptin-melanocortin pathway, influence hunger, the heritability of body weight, and societal factors driving the obesity epidemic, emphasizing the interplay of biology and environment.Key Takeaways:Leptin, discovered through the obese mouse, signals fat levels to the brain, but its absence causes severe obesity and infertility, as seen in rare human mutations.The hypothalamus, a key brain region, senses hormones like leptin and GLP-1, balancing hunger and satiety through POMC (anorexigenic) and AgRP (orexigenic) neurons.Body weight heritability is 40-70% at the population level, but this does not mean that 40-70% of someone's body fat composition is due to genetic factors outside human control. Dr. Yeo unpacks how to think about it.GLP-1 drugs (e.g., Ozempic) mimic gut hormones to reduce appetite, offering some people 15-25% weight loss, but require long-term safety monitoring.According to Dr. Yeo, obesity reflects energy imbalance, but nutritional density matters more than calorie counting for health, and societal changes are needed to prevent it.Related episode:M&M #132: Obesity Epidemic, Diet, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & FeediSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: A mind-bending dive into evolutionary biology and health through a biophysicist's lens, with Dr. Jack Kruse delivering provocative insights about biology, medicine, and health.About the guest: Jack Kruse, MD, is a neurosurgeon known for integrating biophysics into medicine. He challenges conventional biochemistry with his “leptin prescription” and decentralized health approach.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Jack Kruse joins host Nick Jikomes to explore the Great Oxygenation Event's role in shaping life, linking it to modern health via biophysics over biochemistry. They discuss oxygen's impact on metabolism, the significance of deuterium-depleted water, and sunlight's influence on the leptin-melanocortin pathway. Kruse shares his dramatic weight loss journey using sunlight and cold therapy, critiques modern tech-driven obesity, and unveils a controversial history of SV40 in vaccines, tying it to cancer spikes.Key Takeaways:The Great Oxygenation Event (2.1-2.4 billion years ago) drove life's shift to oxygen-based metabolism, with cyanobacteria as key players.Kruse argues biophysics, not biochemistry, explains evolution, spotlighting light as life's fundamental driver.Deuterium-depleted water is important for enabling our cells and mitochondria to use energy from the TCA cycle without “shocking” the body.Sunlight exposure boosts nitric oxide, reducing food needs via the leptin pathway, challenging diet norms.Kruse lost 133 pounds in 11 months using sunlight and cold therapy, inspiring his “leptin prescription.”He links obesity to indoor tech lifestyles, disrupting heme proteins and mitochondrial function.SV40, a virus in 1950s polio vaccines, may connect to cancer rises, a story Kruse says was buried by centralized science.Related episode:M&M #196: Vaccine Contamination & Fiat Science Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: A deep dive into the science of oxidative stress, antioxidants, aging, and neurodegenerative diseases like Alzheimer's.About the guest: Pamela Maher, PhD is a professor at the Salk Institute in San Diego, California, with a focus on neurodegenerative diseases, oxidative stress, and antioxidants.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Pamela Maher discusses her research on cell death mechanisms, including apoptosis and ferroptosis, and their roles in health and disease. They discuss how oxidative stress from reactive oxygen species can damage cells, the body's antioxidant defenses like glutathione and studies on natural compounds—fisetin, curcumin, and cannabinol (CBN)—that may protect against brain cell loss. The conversation covers CBN's mitochondrial benefits in aging mouse models and broader risk factors for dementia, like obesity and hearing loss, emphasizing early intervention.Key Takeaways:Apoptosis is a controlled cell death process vital for development, while ferroptosis, linked to oxidative stress and iron, causes cells to burst and is tied to diseases like Alzheimer's.Oxidative stress arises when reactive oxygen species overwhelm antioxidants, damaging DNA, proteins, and cell membranes, especially polyunsaturated fats.Glutathione, a key antioxidant, relies on cysteine and declines with age, but supplements like N-acetylcysteine might help, though tolerability varies.Cannabinol (CBN), a THC byproduct, protects mitochondria and improves memory in aging mice, hinting at therapeutic potential beyond cannabinoid receptors.Middle-age risk factors like visceral obesity, type 2 diabetes, and hearing loss significantly increase dementia risk, but hearing aids can reduce it.Related episode:M&M #165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical aSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textWhat if the entities we encounter in dreams, visions, or paranormal experiences aren't entirely external… but also not entirely imaginary? In this episode, we explore the mysterious world of thought-forms—psychic constructs created by intense emotion, belief, and concentrated energy. These forms appear across traditions: from Theosophy and Tibetan tulpas, to modern-day spirit guides, shadow people, and even viral mythologies like Slenderman.Are some ghosts, paranormal apparitions, or cryptid encounters actually the externalized contents of the human psyche? We dive deep into the concept of autonomous psychic projections, drawing from Jungian concepts such as archetypes, and spiritual forces that embody or possess familiar images, psychically influencing the world in a variety of ways.This episode also covers: • Egregores and group-created spirits • Astral projection and psychic protections • The power and danger of feeding entities with attention • How folklore, trauma, and imagination blur in high-strangeness • The intersection of parapsychology, magick, and mental healthWhether you see them as protectors, projections, or predators, thought-forms may be closer than you think—and watching you from the edges of your consciousness.Support the showAll episodes are available in video format on YouTube Send your personal experiences (spiritual, paranormal), questions, comments, or business inquiries to: hiddenpassagepodcast@gmail.comYou can also send a voice message through SpeakPipeFollow on Instagram & TwitterPlease consider rating/ leaving a review. Thank you for your support!
Send us a textShort Summary: A detailed examination of shamanism with anthropologist Manvir Singh, blending evolutionary theory and vivid storytelling.About the guest: Manvir Singh, PhD is an anthropologist at the University of California, Davis. His new book, "Shamanism: The Timeless Religion," comes out on May 25, 2025.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Manvir Singh discusses shamanism's role as a universal human practice, exploring its roots in cultural evolution, cognitive tendencies, and persistence across history and modern society. They discuss how shamans use altered states to address uncertainty—like healing or divination—while examining shamanism's interplay with centralized religion, its psychological benefits, and parallels in today's world, from tech gurus to medical placebos.Key Takeaways:Shamanism is a widespread cultural practice involving specialists who enter altered states to engage with unseen forces, often for healing or managing uncertainty.It's not an archaic precursor to modern religion but a recurring expression of spiritual beliefs & practices, competing with other forms.Techniques vary widely—dance, music, psychedelics—but only about half of shamans historically used psychoactive substances.Modern parallels include tech CEOs and money managers who project exceptionalism to influence others, echoing shamanic charisma without trance.Open-label placebos (where patients know it's fake) still work, suggesting rituals alone can trigger healing, much like shamanic practices.Singh sees shamanism as a cognitive technology, not inherently good or bad, shaping how we cope with chaos across cultures and time.Related episode:M&M #86: Shamanism, Psychedelics, Social Behavior, Religion & Evolution of Human Culture | Michael Winkelman*Not medical advice.Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: How environmental chemical exposures affect neurodegenerative disease and health.About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly Parkinson's and Alzheimer's diseases.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Gary Miller talks about neurodegenerative diseases like Parkinson's and Alzheimer's, exploring their age-driven nature, early detection challenges, and environmental risk factors such as pesticide exposure and head trauma. They discuss the emerging field of exposomics—studying lifetime chemical exposures—and its potential to uncover links between pollutants, diet, and disease, while highlighting protective factors like caffeine and nicotine, and the role of technology in advancing prevention and treatment.Key Takeaways:Neurodegenerative diseases like Parkinson's & Alzheimer's worsen with age, but early intervention could slow progression & improve quality of life.Parkinson's symptoms often appear after significant dopamine neuron loss, but subtle signs like handwriting changes or gait issues might be detectable earlier.Environmental factors, including pesticides & air pollution, increase neurodegeneration risk, while caffeine and nicotine surprisingly lower Parkinson's incidence.The exposome—total lifetime exposure to chemicals—offers a new lens to study health, revealing how pollutants & diet interact with our biology.Ultra-processed foods & common chemicals like PFAS (in packaging) raise exposure levels, but simple steps like air filters or less processed diets can help reduce risks.Related episode:M&M #145: Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of ASupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: Do elephants and other animals have language-like abilities, such as the ability to use individual names to refer to themselves and others?About the guest: Michael Pardo, PhD studies animal behavior at Cornell University, where he focused on animal communication and cognition. His work includes extensive field research with African elephants in Kenya.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Michael Pardo, PhD talks about his research on animal communication, focusing on whether African savanna elephants use vocal "names" to address each other. They explore the broader context of vocal communication across species like dolphins, parrots, and marmosets, discussing how these systems compare to human language and what they reveal about its evolution. Dr. Pardo shares details of his fieldwork in Kenya, elephant social structures, and their behaviors like mourning the dead, while also touching on the challenges and joys of studying animals in their natural habitats.Key Takeaways:Elephants may use unique vocal rumbles to address specific individuals.Dolphins use signature whistles as "calling cards," sometimes imitating others' whistles to get their attention, hinting at a form of naming.Elephant society features female-led family groups and dispersing males.Elephants show intriguing behaviors like visiting carcasses and covering them with dirt, suggesting an awareness of death uncommon in most animals.Human language evolution may have evolved gradually from simpler communication systems, as seen in various species, rather than emerging suddenly.Studying less charismatic animals like chickens could uncover surprisingly complex communication, broadening our understanding of cognition in nature.Related episode:M&M #20: Language, Symbolic Cognition, Evolution, Origins of the Human Mind Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: The science of cancer and immunity with Dr. Roychoudhuri, blending cutting-edge research with everyday implications like aspirin's role in fighting tumor metastasis.About the guest: Rahul Roychoudhuri, PhD is a Professor of Cancer Immunology at the University of Cambridge. His research bridges basic science and clinical applications, focusing on immune responses to cancer development and spread.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: The immune system's role in detecting and fighting cancer, particularly how cancer cells evade immunity through selection pressures and microenvironment manipulation. They explore cancer initiation via mutations and inflammation, metastasis mechanics, and a surprising link between low-dose aspirin and reduced cancer spread, spotlighting new research on T cells and thromboxane. The discussion ties in dietary fats, aspirin's anti-inflammatory and anti-clotting effects, and the potential for new therapies to prevent metastasis.Key Takeaways:The immune system constantly surveils and eliminates early cancer cells, but surviving cancers evolve to dodge detection.Inflammation can both spark cancer growth and be exploited by tumors to suppress helpful immune responses.Cancer metastasis, responsible for ~90% of cancer deaths, involves cells breaking off, traveling, and adapting to new sites.New research shows aspirin may curb metastasis by lowering thromboxane, a lipid-derived blood clotting factor.Human data hints aspirin reduces metastasis risk in cancers like breast and colorectal, but trials are ongoing.Daily low-dose aspirin (75-100 mg) is used for heart health, yet its cancer benefits need more study. 600 mg per day has been observed to reduce metastasis rates in colon cancer patients, but chronic use of that dose carries some risk (ulcers, bleeding).*Not medical advice.Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: How dietary fructose affects the growth rate of cancer.About the guest: Gary Patti, PhD is a professor at Washington University in St. Louis, holding appointments in chemistry, medicine, and geneticsNote: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick Jikomes talks to Dr. Patti, exploring how cancer cells metabolize sugars like glucose and fructose, focusing on a recent study showing fructose indirectly boosts tumor growth in mice via liver-produced lipids called LPCs. The discussion covers cancer biology basics, Warburg effect, tumor microenvironments, and systemic metabolic impacts of cancer, while also touching on dietary implications, fasting, and the complexities of nutrient use in cancer progression.Key Takeaways:Cancer cells often rely heavily on glucose, excreting it as lactate even when oxygen is available (Warburg effect), but take up more than their mitochondria can handle.In a study, high fructose diets accelerated tumor growth in mice by 4x, not because cancer cells use fructose directly, but because the liver converts it to LPCs, which tumors use to build membranes.Tumors are not just cancer cells; they recruit healthy cells in their microenvironment, and their metabolic effects ripple across the entire body, altering distant tissues.Excessive fructose consumption may worsen tumor growth, but cutting it poses little risk and could benefit cancer patients, pending human studies.Fasting may reduce cancer initiation risk in animals, but its effect on existing tumors is less clear and could worsen wasting (cachexia) in late stages.The body tightly regulates blood glucose via the liver, so simply cutting dietary glucose won't starve tumors, highlighting cancer's metabolic adaptability.Related episode:M&M #200: Dietary Fats & Seed Oils in Inflammation, Colon CancerSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: How diet shapes the gut microbiome and impacts health, with microbiologist Dr. Peter Turnbaugh breaking down the complex science.About the guest: Peter Turnbaugh, PhD is a professor of microbiology and immunology at the University of California, San Francisco, where he leads a lab studying the gut microbiome's role in nutrition and drug response.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick talks to Peter Turnbaugh discuss the pitfalls of oversimplified diet labels in research, Turnbaugh's studies comparing plant-based and animal-based diets in humans, and how these shifts rapidly alter gut microbes and short-chain fatty acid profiles. Key Takeaways:The term “high-fat diet” in research is often misleading, as it can include high carbs and vary widely, complicating study comparisons.In a 2014 study, switching humans to a plant-based (high-fiber) or animal-based (ketogenic, no-fiber) diet changed their gut microbiome within one day, showing its remarkable adaptability.Ketogenic diets reduce Bifidobacterium in the gut, which may lower inflammation-linked immune cells (Th17), potentially aiding conditions like multiple sclerosis.Short-chain fatty acids (e.g., butyrate) don't just come from fiber; they persist even on zero-fiber ketogenic diets, hinting at alternative microbial pathways.Gut microbes can activate or deactivate drugs, like antibiotics or digoxin, suggesting microbiomes may explain why drugs work differently across individuals.Ketone bodies like BHB alone can mimic some ketogenic diet effects on the microbiome and immunity, simplifying research and hinting at therapeutic potential.Related episode:M&M #203: Metagenomics, Microbiome Transmission, Gut Microbiome in Health & Disease | Nicola Segata*Not medical advice.Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: The science of diabetes with Dr. Scott Soleimanpour, blending personal insights and cutting-edge research that gets into mitochondrial biology and more.About the guest: Scott Soleimanpour, MD, is a physician-scientist at the University of Michigan, where he runs a lab studying pancreatic beta cell biology and mitochondrial quality control in diabetes.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick Jikomes interviews Dr. Scott Soleimanpour about the biology of diabetes, exploring the pancreas's dual role in digestion and blood sugar regulation via beta cells, which produce insulin. They discuss type 1 diabetes as an autoimmune condition with rising incidence and complex beta cell issues, and type 2 as a progressive disease tied to beta cell failure, not just obesity. The conversation covers mitochondrial function in beta cells, lifestyle factors like diet, and the limits of current treatments, offering practical advice for prevention and management.Key Takeaways:The pancreas has two parts: the exocrine (98%) makes digestive enzymes, while the endocrine (1-2%) regulates blood sugar with hormones like insulin from beta cells.Type 1 diabetes involves autoimmunity and intrinsic beta cell defects, with rates increasing due to environmental factors, not just genetics.Type 2 diabetes hinges on beta cell dysfunction, not obesity alone—only 1 in 5 overweight people develop it, showing other factors matter.Beta cells are energy-intensive and long-lived, relying on mitochondria; stress from overwork (e.g., excess insulin demand) can lead to failure.Current diabetes drugs don't rejuvenate beta cells; only TZDs (rarely used) preserve function, highlighting a gap in treatment.Related episode:M&M #140: Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic DysfSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: A rare, insider's look at the messy realities of scientific research with Stanford's Dr. John Ioannidis. The good, the bad, and the ugly about how scientific research actually works.About the guest: John Ioannidis, MD, PhD is a professor at Stanford University in medicine, epidemiology, population health, and biomedical data science, with an MD from the University of Athens and a PhD from Harvard in biostatistics. He directs the Meta-Research Innovation Center at Stanford (METRICS), focusing on improving research methods and practices. Renowned for his paper “Why Most Published Research Findings Are False,” he's among the most cited scientists globally, tackling biases and reproducibility in science.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Key Takeaways:Science's “replication crisis” isn't new—it's baked into how tough and bias-prone research is, hitting all fields, not just “soft” ones like psychology.Ioannidis's famous claim, “most published findings are false,” holds up: stats show many “significant” results are flukes due to weak studies or bias.Peer review's a mixed bag—only a third of papers improve, and unpaid, tired reviewers miss a lot, letting shaky stuff slip through.Publishing's a $30 billion game with 50,000+ journals; big players like Elsevier rake in huge profits from subscriptions and fees, often over $10,000 per paper.Researchers game the system—think fake co-authorships or citation cartels—boosting metrics like the H-index, which tracks papers with matching citation counts.Ioannidis's early COVID-19 fatality rate (0.2-0.3%) was spot-on but sparked a firestorm as politics warped science into “clan warfare.”NIH funding's clogged by red tape and favors older researchers, starving young innovators and risky ideas that could shake things up.He's building tools like a public database of scientist stats (4 million downloads!) to spotlight gaming and push for transparent, fair research.*Not medical advice.Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: Personalized health monitoring with Professor Michael Snyder, blending cutting-edge science with practical tips and actionable insights.About the guest: Michael Snyder, PhD is a Professor of Genetics at Stanford University School of Medicine. He directs the Center for Genomics and Personalized Medicine, which focuses on big data and health innovation. Snyder holds a PhD from Caltech and completed postdoctoral work at Stanford. His career has spanned yeast genomics to human health profiling. Currently, he leads research on advanced molecular and wearable technologies while spinning off companies like Q Bio to translate findings into real-world health solutions.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick talks to Dr. Michael Snyder about transforming medicine through personalized health monitoring, leveraging tools like wearables, continuous glucose monitors, and deep molecular profiling. They explore how diet, microbiome, and genetics shape metabolic health, delving into Snyder's research on diabetes subtypes, short-chain fatty acids, and aging patterns. The conversation also covers practical technologies available today, like smartwatches and home blood tests, and their potential to catch diseases early and extend healthy lifespans.Key Takeaways:Medicine is shifting from sick care to proactive health care using comprehensive data from wearables and molecular profiling.Diabetes has many subtypes, not just type 1 or 2, and treatments like drugs or diet should match an individual's specific profile.Dietary fiber boosts gut health by producing short-chain fatty acids, which influence gene expression and may reduce leaky gut risks.Aging isn't linear—big changes spike in the 40s and 60s, varying by person (e.g., heart, kidneys, metabolism), offering chances to adjust lifestyles early.Wearables like fitness watches can detect illnesses (e.g., COVID, Lyme) days before symptoms by tracking heart rate shifts.Continuous glucose monitSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
To wrap up Horror Romance Month, we're diving into Happy Death Day! This film uniquely blends genres, offering a fresh take where the romance isn't the source of horror. Instead, we get a wholesome love story within a slasher-horror-comedy. And on top of all that, who doesn't love a good time loop?! Tangents include: Apple Cider Vinegar and Bump Its.If you have seen Happy Death Day we would love to know what you thought about it! Let us know on social media or YouTube!Shoutouts: @africabrookeHappy Death Day (2017)Director: Christopher LandonTawny's rating: 4/5Felicia's rating: 4.25/5Send us a textSupport the showAll things TCHF: https://linktr.ee/twochicksandahorrorflickSupport the Show:Join our Patreon: https://www.patreon.com/twochicksandahorrorflickTCHF shop: https://twochicks.threadless.com/designs/podcast-cover-art/Connect with Us:Join our horror community on Discord: https://discord.gg/8WBByTQPFXWatch us on YouTube: https://www.youtube.com/@twochicksandahorrorflickFollow us on Social:Instagram: https://www.instagram.com/twochicksandahorrorflickFacebook: https://www.facebook.com/twochicksandahorrorflickTikTok: https://www.tiktok.com/@twochicksandahorrorflickTwitter: https://twitter.com/twochicksHF Send us your reviews, thoughts, and recommendations: twochicksandahorrorflick@gmail.com or visit our site https://www.twochicksandahorrorflick.com/
Send us a textShort Summary: Insider's look at the COVID-19 pandemic response from a seasoned epidemiologist, unraveling myths and lessons with straightforward science.About the guest: Martin Kulldorff, PhD is an epidemiologist and biostatistician with decades of experience in infectious disease monitoring and vaccine safety. He was formerly a professor at Harvard Medical School. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Martin Kulldorff discusses the COVID pandemic response, reflecting on the controversial Great Barrington Declaration, which opposed lockdowns in favor of protecting the vulnerable. They explore the virus's fatality rates, asymptomatic spread, and vaccine efficacy, contrasting textbook epidemiology with real-world decisions. He critiques institutional failures, like the CDC's misleading claims. He shares optimism for future pandemics with better leadership and public awareness.Key Takeaways:Lockdowns ignored basic public health principles, causing collateral damage like missed cancer screenings, while Sweden's focused protection approach led to lower excess mortality.Early data showed COVID's risk was 1000x higher for older people, yet lockdowns didn't prioritize them, unlike textbook strategies.Asymptomatic spread made containment impossible, unlike Ebola, where isolation works due to clear symptoms.Natural immunity was downplayed despite 2500 years of evidence, leading to wasted vaccines on those already immune.CDC falsely claimed vaccines stopped transmission, eroding trust when people got sick anyway, fueling vaccine skepticism.mRNA vaccine boosters lack proper trials, and their long-term effects need rigorous study, not assumptions.Kulldorff's new Journal of the Academy of Public Health pushes open peer review to rebuild trust in science.Related episode:M&M #100: Infectious Disease, Epidemiology, Pandemics, Health Policy, COVID, Politicization Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: Thyroid biology, offering insights into its role in metabolism, development, and longevity, making it a fascinating listen for those interested in how our bodies manage energy and health across the lifespan.Guest: Diana van Heemst, PhD is a biologist at Leiden University Medical Center, specializing in gerontology and geriatrics. Her research focuses on the neuroendocrine biology of aging and longevity in humans, particularly involving thyroid functions.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Full Summary: Dr. Diana van Heemst explores the thyroid's critical role in metabolism, growth, development, and transitions across life stages. It discusses the thyroid's evolutionary history, its location in the neck, and how it functions through hormone secretion, specifically T3 and T4. The conversation covers the importance of nutrients like iodine and selenium, the impact of thyroid hormone on various bodily functions, and the implications for health conditions like hypothyroidism and hyperthyroidism. It also touches on how thyroid activity might relate to longevity.Key Takeaways:Thyroid Hormones: T3 and T4 are crucial, with T3 being the active form that regulates metabolism, heart rate, and cognitive functions.Iodine and Selenium: Essential for thyroid hormone synthesis; iodine is unique to thyroid hormones, while selenium is vital for the enzymes that regulate hormone availability.Hypothyroidism vs. Hyperthyroidism: Hypothyroidism is more common, especially in older age due to autoimmune issues, leading to symptoms like fatigue and cold sensitivity. Hyperthyroidism can result from iodine excess or autoimmune conditions like Graves' disease.Developmental Role: Thyroid hormones are vital for major developmental transitions, from birth to puberty, impacting brain development and metabolic adaptation.*Not medical advice.Support the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Use your phone's link. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textThe astral realm is a world in flux—where spirits take form, emotions sculpt the landscape, and unseen entities move through the shifting tides of thought and energy. In this episode, we explore the beings that inhabit this plane, from nature spirits (fairies) and elementals to the eerie presence of shades—echoes of the dead that can take on a life of their own, sometimes possessed by other spirits and entities. We also discuss magical adepts, spiritual practitioners- both white and black- who allegedly have power over life and death itself, manipulating their cycle of reincarnation, be it through intense spiritual training or vampirism. In doing so they are able to travel through and remaining on the astral plane for as long as they see fit, projecting their apparitions into the material world. Through a mix of esoteric insights and firsthand listener stories, encounters with paranormal, supernatural beings, we uncover the hidden mechanisms behind these phenomena and consider what they may reveal about the nature of the astral plane itself and how its forces interact with us. Join me as we navigate the unseen forces shaping this mysterious dimension, where perception is power, and reality is never quite what it seems.#theosophy #occult #spiritualSupport the showAll episodes are available in video format on YouTube Send your personal experiences (spiritual, paranormal), questions, comments, or business inquiries to: hiddenpassagepodcast@gmail.comYou can also send a voice message through SpeakPipeFollow on Instagram & TwitterPlease consider rating/ leaving a review. Thank you for your support!
For Valentines Day week, we are diving headfirst into Your Monster (2024)—a movie that dares to ask: what if your emotional baggage had claws, fangs, and a serious case of the hots for you? Equal parts horror, romance, and quirky dark fairytale, this film is giving us Beauty and the Beast meets Jennifer's Body, and we are here for it. Expect lots of laughs and plenty of fun! This episode is light on tangents, making it the perfect quickie—just enough horror fun before you get back to your Valentine's plans!
Send us a textShort Summary: The complexities of neurodegenerative disease, particularly Alzheimer's, environmental influences like glyphosate, and the crucial role of nutrients like choline, with actionable insights into brain health management.About the guest: Dr. Ramon Valazquez is an Assistant Professor at Arizona State University, leading a research lab at the Neurodegenerative Disease Research Center. His work focuses on environmental factors related to Alzheimer's and other dementias, alongside developing therapeutic strategies.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Ramon Velazquez explores neurodegenerative disease, with a deep dive into Alzheimer's, its pathophysiology including amyloid beta plaques and tau pathology. It examines the controversy around these proteins' roles in disease progression, the influence of environmental toxins like glyphosate on brain health, and the preventive potential of nutritional interventions, particularly choline.Key Takeaways:Neurodegenerative Disease Basics: Alzheimer's disease involves both amyloid beta plaques and tau tangles, with tau pathology more closely linked to clinical symptoms.Environmental Impact: Glyphosate, a common herbicide, can cross into the brain, potentially exacerbating neurodegenerative pathways through inflammation.Choline: Essential for brain function and fat metabolism, it's often deficient in diets, particularly plant-based ones. Adequate intake might prevent or mitigate cognitive decline and related diseases.Preventive Measures: Early nutritional intervention, like maintaining choline levels, could be vital for preventing neurodegenerative diseases. However, once symptoms are present, such interventions might not reverse existing pathology.Related episode:M&M #145: Epigenetics, HormonesSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Use your phone's link. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts
Send us a textShort Summary: The science of glycosylation, its impact on health, and potential treatments for congenital disorders of glycosylation (CDGs).About the guest: Dr. Eva Morava is a pediatric geneticist originally from Hungary, who has specialized in inborn errors of metabolism, particularly CDGs. She has a background in pediatrics and genetics from training in Hungary and the U.S., and currently leads the genetics and genomics department at Mount Sinai.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Eva Morava discusses the critical role of glycosylation in biology, where sugars are not just used for energy but in modifying proteins to perform their functions. She explains how defects in this process lead to CDGs, a group of rare genetic disorders. The conversation covers the mechanics of glycosylation, clinical presentations of CDGs, current research on treatments including dietary interventions and gene therapy, and the broader implications of glycosylation in health, such as in liver disease and cancer.Key Takeaways:Glycosylation Basics: Sugars are attached to proteins (glycosylation) to modify their structure and function, influencing everything from clotting to immune response.CDGs: These disorders are caused by genetic defects in the glycosylation process, leading to a wide array of symptoms because many proteins require glycosylation to function correctly.Clinical Variability: CDGs can range from severe, multi-systemic presentations to relatively mild cases, affecting life expectancy and quality of life variably.Therapeutic Approaches: Current research includes drug repurposing for enzyme activity enhancement, dietary interventions with special sugars like mannose, and gene therapy, with some trials underway.Liver Connection: A significant portion of glycosylation occurs in the liver; thus, liver diseases like non-alcoholic fatty liver disease can impact glycosylation.*Not medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts
Send us a textShort Summary: How human culture and psychology have evolved, particularly exploring the unique psychological traits of "WEIRD" (Western, Educated, Industrialized, Rich, Democratic) societies, providing insights into why our minds and societies are the way they are today.About the Guest: Joe Henrich, PhD is a professor of human evolutionary biology at Harvard University. His research focuses on applying evolutionary theory to understand the human mind and culture, particularly how cultural evolution has led to the emergence of WEIRD psychology.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere.Key Takeaways:WEIRD Psychology: WEIRD stands for Western, Educated, Industrialized, Rich, and Democratic, highlighting unique psychological traits like individualism and analytic thinking which are not universal but specific to Western societies.Marriage & Kinship: The Western Church's marriage policies, promoting monogamy and the nuclear family, contributed to the dissolution of extended kinship networks, fostering individualism in Western societies.Institutional Influence: Institutions in WEIRD societies, like universities and legal systems, focus on individual rights and mental states, contrasting with other cultures emphasizing group or kin loyalty.Modern Challenges: Henrich touches on current issues like the impact of dating apps on mating markets, potentially leading to social instability due to increased male-female inequality in mating success.Future of Religion and Culture: The conversation speculates on the future evolution of religion and cultural practices, suggesting that religions fostering high fertility and communal support might gain prominence.Related episode:M&M #129: Biological Sex, Sexual Selection, Sex Behavior, Mating Strategies, Sexual Orientation, Monogamy & Polygyny | David Puts*Not medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts
Skip the banter: 00:06:52Allison tells us the story of the Nutty Putty Cave, a once-popular spelunking site turned fatal trap. In November 2009, John Edward Jones, a young medical student and experienced caver, ventured into the cave's maze-like depths, only to find himself trapped in an unimaginable nightmare.Amazon stuff we mentioned (we get a bonus if you order anything through this link - thanks for your support!): https://www.amazon.com/shop/crimeandcoffee2/list/2UNVF9JKQR2KG?ref_=cm_sw_r_cp_ud_aipsflist_YPBGMSRJJQ6XYJZMAKDX YouTube video from our home studio: https://youtu.be/rXBakCXMK0oSupport the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
Send us a textShort Summary: Deep dive into systems biology and personalized medicine, exploring how technology and data can revolutionize health care, artificial intelligence, biotechnology, and the future of medicine.About the Guest: Dr. Lee Hood is a pioneering scientist with a 60-year career in biology, notably at Caltech and the University of Washington. He co-founded the Institute for Systems Biology and has significantly contributed to molecular immunology and the Human Genome Project, holding a PhD in biology.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere.Key Takeaways:Systems Biology: Understanding complex biological systems by analyzing how individual components interact.Data-Driven Health: Use of genomic and phenomic data can lead to personalized health strategies, enhancing wellness and preventing chronic diseases before they manifest.AI in Medicine: AI can augment human capabilities in medicine, acting as a vast knowledge base to assist physicians in diagnosis and treatment, potentially leading to a partnership model between AI and human doctors.Chronic Disease: Much of the chronic disease burden could potentially be mitigated through lifestyle changes rather than solely through pharmaceutical interventions.Future Drug Development: The traditional focus on single-target drugs might shift towards multi-modal strategies, recognizing diseases like Alzheimer's might be a metabolic disorder.Peptides and New Therapies: Small peptide drugs are emerging as potential new treatments due to their ability to interact with a range of biological molecules, offering new possibilities beyond traditional small molecule drugs.Environmental Impact on Health: While personal behavior significantly influences health outcomes, environmental factors like exposure to toxins can also play critical roles in disease development.Related episodes:M&M #204: Preventive Medicine, Personalized Nutrition & Changing Your Microbiome | Momo VuyisichSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts
Get 45% off the Magic Mind bundle with with the link: https://www.magicmind.com/CHICKSJAN #magicmind #mentalwealth #mentalperformance Years in the making...Tawny finally subjects Miriam to this violent horror western! Not shockingly we both loved it. The cast and atmosphere are great especially considering this was S. Craig Zahler's directorial debut and the budget was under 2 million dollars! Tangents include: Miriam going back to school, Severance, and how terrible Folie a Deux was.If you have seen Bone Tomahawk we would love to know what you thought about it! Let us know on social media or YouTube!Bone Tomahawk (2015)Director: S. Craig ZahlerTawny's rating: 4.9/5Felicia's rating: 4.5/5Send us a textSupport the showAll things TCHF: https://linktr.ee/twochicksandahorrorflickSupport the Show:Join our Patreon: https://www.patreon.com/twochicksandahorrorflickTCHF shop: https://twochicks.threadless.com/designs/podcast-cover-art/Connect with Us:Join our horror community on Discord: https://discord.gg/8WBByTQPFXWatch us on YouTube: https://www.youtube.com/@twochicksandahorrorflickFollow us on Social:Instagram: https://www.instagram.com/twochicksandahorrorflickFacebook: https://www.facebook.com/twochicksandahorrorflickTikTok: https://www.tiktok.com/@twochicksandahorrorflickTwitter: https://twitter.com/twochicksHF Send us your reviews, thoughts, and recommendations: twochicksandahorrorflick@gmail.com or visit our site https://www.twochicksandahorrorflick.com/
Skip the banter: 00:06:16Imagine falling in love with someone who seems like your dream partner. Confident, assertive, and charming, they sweep you off your feet. But what if those very traits that once attracted you turn into your biggest nightmare? On a quiet New Year's Eve, Morgan Metzer, a single mother from Canton, Georgia, was looking forward to a peaceful evening with her best friend after a challenging year. Little did she know, her night would take a terrifying turn. Awakened by fireworks, Morgan soon faced a far more sinister reality - a masked intruder in her home who knew intimate details of her life. Allison tells us her story.YouTube video from our home studio: https://youtu.be/fk8mnpFSzKYSupport the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
Send us a textShort Summary: Deep dive into preventive medicine, personalized nutrition, and systems biology, providing listeners with actionable insights on optimizing health through diet & microbiome management.About the guest: Momo Vuyisich is a biologist with a background in government science, focusing on drug development before shifting to preventive medicine. He holds a PhD in biochemistry and is currently Chief Science Officer of Viome, a startup company dedicated to personalized health through microbiome analysis.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and for free on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Vuyisich discusses the transformative potential of preventive medicine by drawing parallels between human health and systems biology, particularly through the lens of the gut microbiome. He explains how Viome uses comprehensive testing (stool, blood, saliva), providing personalized dietary and supplement recommendations based on individual physiological data. Covers the complexity of diseases like IBD, the impact of modern lifestyle on our microbiome, and more.Key Takeaways:Disconnection from Nature: Modern lifestyles have disrupted our symbiotic relationship with nature, leading to microbiome degradation through factors like antibiotics, preservatives, and hygiene practices.Personalized Nutrition: Viome's approach involves tailoring food recommendations & supplements to an individual's unique microbiome and physiological needs, highlighting that food impacts can vary greatly between individuals.Testing for Prevention: Regular testing with tools like Viome's full body intelligence test can help in making informed dietary changes to prevent diseases before they manifest.Lifestyle Over Medication: Many chronic conditions can potentially be managed or prevented through lifestyle adjustments rather than lifelong medication, emphasizing the need for a preventive rather than reactive strategy.Related episodes:M&M #178: Microbiome & Gut-Immune InteractionsSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts
0:01:44: NXIVM: The Vow 0:02:34: Leah Remini: The King of Queens star sues Church of Scientology 0:03:30: The Truth About Jared Leto's Bizarre Cult - Camp Mars 0:04:34: NXIVM: Allison Mack, Grace Park and Other Actors Recruited by the Cult 0:06:15: What Is Gemini? Everything You Should Know About Google's AI Tool 0:07:51: Terminator 0:09:30: Fake Luigi Mangione Alibis - Know Your Meme 0:10:06: Supreme Court Will Hear TikTok Ban This Week—Here's What To Expect 0:11:46: Slightly High Historian 0:12:00: Glitter & Greed: The Lisa Frank Story 0:12:40: Annie (2014) 0:15:16: Here's why YouTube's bugging you about your age 0:20:34: This year has been exhausting! 0:22:12: France and Germany falter as Trump presidency looms South Korea's President Declared Martial Law Syrian rebels topple Assad who flees to Russia in Mideast shakeup Gaza is still happening France's Prime Minister was kicked out Trudeau says 'not a snowball's chance in hell' Canada will join US 0:28:16: Rebekah Weatherspoon on TikTok 0:30:29: The Move Bombing 0:31:00: Here's why all your streaming services cost a small fortune now 0:31:55: Fav media of the year Homicide: Life on the Street Copaganda Diablo Dropout TV This Ravenous Fate The Rise of YA Fiction and Why It's so Important X-Men 97 Interview with the Vampire Agatha All Along The Penguin The Batman 2002 Alligator Bites Never Heal GNX Hiss 0:43:19: Nicki Minaj is in debt 0:44:37: Lil Wayne & The Superbowl 0:46:12: Watch Beyoncé Bowl | Netflix Official Site 0:50:41: BoxLunch 0:52:34: Was Luigi Mangione Charged With Terrorism While the Buffalo Supermarket Shooter Was Not? 0:54:04: Ryan Murphy Defends ‘Monsters' Against Erik Menendez Criticism and Backlash Over Homoerotic Brother Scenes: ‘We Had an Obligation to Show All of That' 0:55:24: Divorce in the Black 0:56:20: Jonathan Majors and Megan Good are engaged. 0:56:49: Jim Brown was a monster 0:59:45: Meagan Good on Eyebrow Tattoos 1:00:46: Wicked 1:05:08: What we're thankful for 1:10:03: Where to find your hosts! Check out our carrd to see where you can find us! https://nerdgasmnoire.carrd.co/ Make sure you join our new discord channel and hang out with the community! discord.gg/7DqMZSy ENJOY! Hosts: De, Jamie, JP, Maria, Melissa, Storm Producer: De, Jamie, JP, Maria, Melissa, Storm Writing Team: De, Jamie, JP, Maria, Melissa, Storm Editor: De Audio Production: De Theme Song: Feelin Good provided by Mike (Pound 4 Pound Podcast) & Marion Moore from ALBM Production Design: JP Fairfield Social Media: Melissa, Storm
Skip the banter: 00:05:02In a chilling tale of wealth, privilege, and tragedy, a 16-year-old boy's decision to drive drunk leads to devastating consequences. Allison not only explores the night of horror that unfolded in Burleson, Texas, but she also delves into the controversial legal defense of "affluenza" - a term that would spark a national debate on justice and accountability. Discover how one fateful night forever altered the lives of many, raising questions about the role of privilege in our legal system. Will justice prevail, or will wealth pave the way for leniency? Listen to uncover the full story.SodaStream we talked about: https://amzn.to/3C7VbknEpisode video from our home studio (like and subscribe - it's good luck!): https://youtu.be/o5FOErpVVTESupport the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
Send us a textShort Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and diverse manifestations across different species.About the Guest: Nicola Segata, PhD is a professor at the University of Trento in Italy.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube. Partial versions are available elsewhere.Episode Summary: Dr. Segata explains metagenomics, the study of genetic material from multiple species, and how it has revolutionized microbiome research; microbiome transmission from mother to child; stability and plasticity of the microbiome throughout life stages; obesity and cancer; influence of diet, lifestyle, and medications like antibiotics on microbiome composition.Key Takeaways:Microbiome Variability: The human microbiome varies significantly between individuals and is influenced by genetics, environment, diet, and lifestyle. Thus, personalized approaches to microbiome health may be necessary.Transmission and Acquisition: Microbes are transmitted vertically from mother to child at birth and horizontally through personal interactions. This transmission can influence health outcomes over one's lifetime.Impact of Diet and Drugs: Diet, particularly coffee consumption, can significantly shape the microbiome, with some bacteria growing in response to specific dietary components. Medications like antibiotics and proton pump inhibitors can also markedly alter microbial communities.Health Implications: The microbiome is linked to various health conditions, from metabolic diseases to cancer, with some treatments like fecal microbiota transplantation showing promise in altering microbiome composition for health benefits.Ancient vs. Modern Microbiomes: Studies on ancient microbiomes, like the Iceman's, suggest that modern urban microbiomes differ from those of our ancestors, potentially impacting modern health issues.Related episodes:M&M #178: Microbiome & Gut-Immune Interactions in Obesity & Metabolic Health | June RSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts
Send us a textShort Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and the diverse manifestations across different species.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube. Partial versions are available elsewhere.About the Guest: Vlad Vyazovskiy, PhD is a Professor of Sleep Physiology at the Department of Physiology, Anatomy, and Genetics at Oxford University.Key Takeaways:Sleep as a Mystery: Despite extensive research, the fundamental reason why animals sleep remains elusive, with no comprehensive theory yet agreed upon.Local Sleep Phenomenon: Sleep might not be a whole-brain event; even within a sleeping brain, different areas can be in different states of activity or rest.Sleep in Animals: Sleep varies widely among species, from micro-sleeps in penguins to unihemispheric sleep in dolphins, suggesting sleep could serve multiple, context-dependent functions.Synaptic Homeostasis: The hypothesis suggests that sleep could be crucial for renormalizing synaptic connections formed during wakefulness, although this idea is still under scrutiny.Hibernation & Torpor: These states relate to sleep but involve significant metabolic changes, possibly acting as survival mechanisms by conserving energy and reducing detectability by predators.Psychedelics & Sleep: Research shows psychedelics like 5-MeO-DMT can induce states where animals show signs of sleep in their brain activity while physically active, hinting at complex interactions between brain states and consciousness.Related episodes:M&M #43: Sleep, Dreaming, Deep Neural Networks, Machine Learning & Artificial Intelligence, Overfitted Brain Hypothesis, Evolution of Fiction & Art | Erik HoelM&M #16: Sleep, Dreams, Memory & the Brain | Bob Stickgold*Not medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts
Skip the banter: 00:07:39Allison tells us the story around the tragic death of Ashley Fallis on New Year's Eve 2011. She was found dead from a gunshot wound shortly after midnight. Ashley and her husband, Tom, were hosting a party at their home in Colorado when tensions reportedly rose, culminating in a heated argument. Tom claimed that Ashley committed suicide, but her family and friends believe she was murdered. Who's right?YouTube of this episode from our home studio: https://youtu.be/q5EW4pIHL2USupport the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
It's the *grand finale* of 2024, and we're wrapping things up in true Two Chicks fashion—by reflecting on the year that was!
Skip the banter: 00:07:51Robot vacuum we bought: https://amzn.to/402wj5EThis case highlights the contrast between outward appearances and the hidden turmoil that can lead to such extreme acts, questioning how well we truly know those around us. This tragedy forces us to consider the complex interplay of mental health, family dynamics, and the potential for violence lurking beneath the surface of seemingly ordinary lives.Support the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
Skip the banter: 00:08:02Support us and become a Patron! Over **100** bonus episodes available RIGHT NOW:https://www.patreon.com/crimeandcoffeecoupleOn a cold December morning in 2015, in the tight-knit community of Ellington, Connecticut, a distressing scene unfolds at the Dabate household. Connie Dabate, known for her fun-loving nature, is found dead in her basement, shot under what initially appears to be a home invasion. Her husband, Rick, is discovered bound to a chair, telling police that a masked intruder was responsible for the chaos and his wife's demise.Sponsor: Check out SmartLabels on Amazon and support our sponsor.YouTube video from our home studio: https://youtu.be/XaH7bbMy4hISupport the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
Send us a textPodcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube. Partial versions are available elsewhere.About the guest: Alex Wiltschko, PhD is the founder and CEO of Osmo, a startup using AI, neuroscience, and chemistry to digitize the sense of smell.Episode summary: Nick talks to Dr. Wiltschko about: the sense of smell & olfactory perception; aroma and why certain molecules are smelled but not others; how the brain encodes odors; using AI and machine learning to create “odor maps”; designing novel scents for the fragrance industry; Osmo and its goal of digitizing the sense of smell.Related episodes:M&M #114: Marijuana, Plant Chemistry, Terpenes, Volatile Sulfur Compounds, Cannabis Industry, What Pungent Weed Smells Like & Why | Iain OswaldM&M #22: Machine Learning, Artificial Intelligence, Animal Behavior & Giving Computers a Sense of Smell | Alex WiltschkoSpecial offer: Use MINDMATTERSPECIAL2 for a free 1-year premium subscription to Consensus, an AI-powered research tool that helps you find the best science, faster. ($150 value, limited-time offer).*This content is never meant to serve as medical adviceSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: Consensus: AI-powered academic research tool. Find & understand the best science, faster. Free 1-year premium sub with code MINDMATTERSPECIAL2 (exp 12.23.24) MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. Learn all the ways you can support my efforts...
Skip the banter: 00:10:02Support us and become a Patron! Over **100** bonus episodes available RIGHT NOW:https://www.patreon.com/crimeandcoffeecoupleor...ask for US for Christmas: https://www.patreon.com/crimeandcoffeecouple/gift
Skip the banter: 00:05:40Support us and become a Patron! Over **100** bonus episodes available RIGHT NOW:https://www.patreon.com/crimeandcoffeecoupleIn a chilling story of disappearance and betrayal set in Oregon City, Oregon, this is the tragic story of two young girls, Ashley Pond and Miranda Gaddis, who vanished in the early 2000s. Their lives, filled with promise, were cut short by a predator closer than anyone imagined.Sponsor: Check out SmartLabels on Amazon and support our sponsor.YouTube video from our home studio: https://youtu.be/EY6ljNrLyEgSubscribe to our podcast so you don't miss an episode! All our links (Spotify, Apple Podcasts, YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:https://www.facebook.com/groups/crimeandcoffeecouplepodcast/Support the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
Skip the banter: 00:04:11Support us and become a Patron! Over 80 bonus episodes available RIGHT NOW:https://www.patreon.com/crimeandcoffeecoupleThis is a listener suggestion from Rebecca & Leanne.This is a shockingly disturbing case that involves a man in the South of France who pleaded guilty in September 2024 to charges of secretly drugging his wife of 50 years over the course of nearly a decade, filming over seventy men as they had sex with her sedated & unconscious body. As this case hit the media, many were left to wonder, how could someone do such an unimaginable thing to a person who had loved, trusted & spent five decades of their life by their side? Who were these other men & how could there possibly be so many willing to rape an unconscious woman?Sponsor: Check out SmartLabels on Amazon and support our sponsor.YouTube video of THIS episode: https://youtu.be/pXIe9ddRCiQAmazon Addiction - color changing lights: https://amzn.to/40Pzq2MSupport the showAll our links (YouTube, Instagram, TikTok, Merch, etc):https://linktr.ee/crimeandcoffeeFacebook Group to discuss episodes:www.facebook.com/groups/crimeandcoffeecouplepodcast/References available at https://www.crimeandcoffeecouple.com a few days after this podcast airs.Case Suggestions Form: https://forms.gle/RQbthyDvd98SGpVq8Remember to subscribe to our podcast in your favorite podcast player. Do it before you forget!If you're listening on Spotify please leave us a 5-star review, and leave a comment on today's episode!If you're on an iPhone, review us on Apple Podcasts please! Scroll to the bottom of the page and hit the stars ;)We appreciate you more than you know.Reminder:Support us and become a Patron! Over 80 bonus episodes:https://www.patreon.com/crimeandcoffeecouplePodcast Intro and Outro music:Seductress Dubstep or TrippinCoffee by Audionautix http://audionautix.comCreative Commons Music by Jason Shaw on Audion...
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